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Conserved domains on  [gi|1278550851|gb|PJA67014|]
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MAG: cation transporter [Piscirickettsiaceae bacterium CG_4_9_14_3_um_filter_43_564]

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 11467717)

cation transporter of the cation diffusion facilitator (CDF) family that facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
1-288 1.23e-80

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


:

Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 245.89  E-value: 1.23e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851   1 MLGDFIMAVFGLVFFYLTRSQAILMDAVYPFVDMVAGLLTLRVVSLMAKQAHQSQPFGYAIFEPVMNFIKGILILLVILV 80
Cdd:COG3965    12 IAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGYWHLEPLVLAIKGLILLLLCLY 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851  81 GLYASIKAIILGGHHIEADIAVFYSVLATVINFALAYVLYRMNQTAQSSMIAVDLQGWIVGGILSVAVGLSFLAVIWMES 160
Cdd:COG3965    92 ALVNAVGSLLDGGREIEFGLALVYALVATVGCFGIALYLRRANRRLRSELVRLDAKAWLMDGLLSAALLVAFILAYLLQG 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851 161 AGYDEWVPYMDPFVLLALIIMMLPMPLKILKENGLQIIGRSDNAEHLAELQQRTSDVFADVPVVDIKLRALQEGRMIYVQ 240
Cdd:COG3965   172 TGLAWLAPYVDPAILALLSLVFLPVPLRIVRQALREVLLMAPPEELDARVREVMEAIVARYGFLDYRSYVAKVGRKLFIE 251
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1278550851 241 AYIQLQPQ-AAFDLNQQDDYRNRLYQQLKQTNDYLSLDVIYTAQPIWVA 288
Cdd:COG3965   252 IYFLVPPDfPARTIEELDAIRDEIADALGDEGPDRWLTISFTADPRWAE 300
 
Name Accession Description Interval E-value
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
1-288 1.23e-80

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 245.89  E-value: 1.23e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851   1 MLGDFIMAVFGLVFFYLTRSQAILMDAVYPFVDMVAGLLTLRVVSLMAKQAHQSQPFGYAIFEPVMNFIKGILILLVILV 80
Cdd:COG3965    12 IAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGYWHLEPLVLAIKGLILLLLCLY 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851  81 GLYASIKAIILGGHHIEADIAVFYSVLATVINFALAYVLYRMNQTAQSSMIAVDLQGWIVGGILSVAVGLSFLAVIWMES 160
Cdd:COG3965    92 ALVNAVGSLLDGGREIEFGLALVYALVATVGCFGIALYLRRANRRLRSELVRLDAKAWLMDGLLSAALLVAFILAYLLQG 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851 161 AGYDEWVPYMDPFVLLALIIMMLPMPLKILKENGLQIIGRSDNAEHLAELQQRTSDVFADVPVVDIKLRALQEGRMIYVQ 240
Cdd:COG3965   172 TGLAWLAPYVDPAILALLSLVFLPVPLRIVRQALREVLLMAPPEELDARVREVMEAIVARYGFLDYRSYVAKVGRKLFIE 251
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1278550851 241 AYIQLQPQ-AAFDLNQQDDYRNRLYQQLKQTNDYLSLDVIYTAQPIWVA 288
Cdd:COG3965   252 IYFLVPPDfPARTIEELDAIRDEIADALGDEGPDRWLTISFTADPRWAE 300
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
6-198 1.08e-29

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 111.21  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851   6 IMAVFGLVFFYLTRSQAILMDAVYPFVDMVAGLLTLRVVSLMAKQAHQSQPFGYAIFEPVMNFIKGILILLVILVGLYAS 85
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851  86 IKAIILGGHHIEADIAVFYSVLATVINFALAYVLYRMNQTAQSSMIAVDLQGWIVGGILSVAVGLSFLAVIWMESAgyde 165
Cdd:pfam01545  81 IQRLLSPGEEIDPGLALILALVSLLVNLFLLLYLRRAARRIRSPALKADALHALSDVLASLGVLISALLIYLGPIT---- 156
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1278550851 166 WVPYMDPFVLLALIIMMLPMPLKILKENGLQII 198
Cdd:pfam01545 157 GGLLADPLASLLIGLLILYTALRLLKESLSILL 189
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
6-247 1.32e-10

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 60.70  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851   6 IMAVFGLVFFYLTRSQAILMDAVYPFVDMVAGLLTLRVVSLMAKQAHQSQPFGYAIFEPVMNFIKGILILLVILVGLYAS 85
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851  86 IKAIILGGHHIEADIAVFYSVLATVINFALAYVLYRMNQTAQSSMIAVDLQGWIVGGILSVAVGLSFLAVIWMesagyde 165
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYFG------- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851 166 wVPYMDPFVLLALIIMMLPMPLKILKENGLQIIGRSDNAEHLAELQQRTSDVFADVPVVDIKLRALQEGrMIYVQAYIQL 245
Cdd:TIGR01297 154 -WHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGVHDLHIWRIGPG-KLFLDVHVVV 231

                  ..
gi 1278550851 246 QP 247
Cdd:TIGR01297 232 DP 233
 
Name Accession Description Interval E-value
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
1-288 1.23e-80

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 245.89  E-value: 1.23e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851   1 MLGDFIMAVFGLVFFYLTRSQAILMDAVYPFVDMVAGLLTLRVVSLMAKQAHQSQPFGYAIFEPVMNFIKGILILLVILV 80
Cdd:COG3965    12 IAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGYWHLEPLVLAIKGLILLLLCLY 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851  81 GLYASIKAIILGGHHIEADIAVFYSVLATVINFALAYVLYRMNQTAQSSMIAVDLQGWIVGGILSVAVGLSFLAVIWMES 160
Cdd:COG3965    92 ALVNAVGSLLDGGREIEFGLALVYALVATVGCFGIALYLRRANRRLRSELVRLDAKAWLMDGLLSAALLVAFILAYLLQG 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851 161 AGYDEWVPYMDPFVLLALIIMMLPMPLKILKENGLQIIGRSDNAEHLAELQQRTSDVFADVPVVDIKLRALQEGRMIYVQ 240
Cdd:COG3965   172 TGLAWLAPYVDPAILALLSLVFLPVPLRIVRQALREVLLMAPPEELDARVREVMEAIVARYGFLDYRSYVAKVGRKLFIE 251
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1278550851 241 AYIQLQPQ-AAFDLNQQDDYRNRLYQQLKQTNDYLSLDVIYTAQPIWVA 288
Cdd:COG3965   252 IYFLVPPDfPARTIEELDAIRDEIADALGDEGPDRWLTISFTADPRWAE 300
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
6-198 1.08e-29

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 111.21  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851   6 IMAVFGLVFFYLTRSQAILMDAVYPFVDMVAGLLTLRVVSLMAKQAHQSQPFGYAIFEPVMNFIKGILILLVILVGLYAS 85
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851  86 IKAIILGGHHIEADIAVFYSVLATVINFALAYVLYRMNQTAQSSMIAVDLQGWIVGGILSVAVGLSFLAVIWMESAgyde 165
Cdd:pfam01545  81 IQRLLSPGEEIDPGLALILALVSLLVNLFLLLYLRRAARRIRSPALKADALHALSDVLASLGVLISALLIYLGPIT---- 156
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1278550851 166 WVPYMDPFVLLALIIMMLPMPLKILKENGLQII 198
Cdd:pfam01545 157 GGLLADPLASLLIGLLILYTALRLLKESLSILL 189
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
1-247 3.34e-19

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 85.16  E-value: 3.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851   1 MLGDFIMAVFGLVFFYLTRSQAILMDAVYPFVDMVAGLLTLRVVSLMAKQAHQSQPFGYAIFEPVMNFIKGILILLVILV 80
Cdd:COG0053     9 LAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAVLILLAGLF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851  81 GLYASIKAIILGGHHIEADIAVFYSVLATVINFALAYVLYRMNQTAQSSMIAVDLQGWIVGGILSVAVGLSFLAVIWMes 160
Cdd:COG0053    89 ILYEAIERLLHPEPVEPSGLGLAVLLISIVVNEALARYLRRVGKKTGSPALKADALHDRSDALTSLGVLIGLLLALLT-- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851 161 aGYdewvPYMDPFVLLALIIMMLPMPLKILKENGLQIIGRSDNaehlAELQQRTSDVFADVP-VVDI-KLRALQEGRMIY 238
Cdd:COG0053   167 -GW----PWLDPIAAILIGLLILKVAYKLARESLSLLMDEALD----EELVERIRAIILSVPgVIGVhDLRTRKSGPRIF 237

                  ....*....
gi 1278550851 239 VQAYIQLQP 247
Cdd:COG0053   238 VDLHIEVDP 246
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
6-247 1.32e-10

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 60.70  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851   6 IMAVFGLVFFYLTRSQAILMDAVYPFVDMVAGLLTLRVVSLMAKQAHQSQPFGYAIFEPVMNFIKGILILLVILVGLYAS 85
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851  86 IKAIILGGHHIEADIAVFYSVLATVINFALAYVLYRMNQTAQSSMIAVDLQGWIVGGILSVAVGLSFLAVIWMesagyde 165
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYFG------- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278550851 166 wVPYMDPFVLLALIIMMLPMPLKILKENGLQIIGRSDNAEHLAELQQRTSDVFADVPVVDIKLRALQEGrMIYVQAYIQL 245
Cdd:TIGR01297 154 -WHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGVHDLHIWRIGPG-KLFLDVHVVV 231

                  ..
gi 1278550851 246 QP 247
Cdd:TIGR01297 232 DP 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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