|
Name |
Accession |
Description |
Interval |
E-value |
| PBP1_ABC_ligand_binding-like |
cd06346 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
52-408 |
8.00e-98 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380569 [Multi-domain] Cd Length: 314 Bit Score: 295.24 E-value: 8.00e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPYEGAWA-VGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATI 130
Cdd:cd06346 2 IGALLPLTGPLAsLGPPMLAAAELAVEEINAAGGVLGKKVELVVEDSQTDPTAAVDAARKLVDVEGVPAIVGAASSGVTL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 131 PAAEVASTRGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFT 210
Cdd:cd06346 82 AVASVAVPNGVVQISPSSTSPALTTLEDKGYVFRTAPSDALQGVVLAQLAAERGFKKVAVIYVNNDYGQGLADAFKKAFE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 211 ALGGEAVASVYSGTDANFAQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSGWIFPDGLKTQGFVDAVaNNQY 290
Cdd:cd06346 162 ALGGTVTASVPYEPGQTSYRAELAQAAAGGPDALVLIGYPEDGATILREALELGLDFTPWIGTDGLKSDDLVEAA-GAEA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 291 LEGALGTVPATLG-ADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAmelsddpndrtqvrdnlaktktgqeihpge 369
Cdd:cd06346 241 LEGMLGTAPGSPGsPAYEAFAAAYKAEY-GDDPGPFAANAYDAVMLLALA------------------------------ 289
|
330 340 350
....*....|....*....|....*....|....*....
gi 1278626266 370 wskvlehladgslnYEGASGAVDLDANGDVTANVEEWTI 408
Cdd:cd06346 290 --------------YEGASGPIDFDENGDVAGPYEIWKV 314
|
|
| LivK |
COG0683 |
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid ... |
52-416 |
2.22e-53 |
|
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid transport and metabolism];
Pssm-ID: 440447 [Multi-domain] Cd Length: 314 Bit Score: 180.51 E-value: 2.22e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPYEGAWA-VGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATI 130
Cdd:COG0683 6 IGVLLPLTGPYAaLGQPIKNGAELAVEEINAAGGVLGRKIELVVEDDASDPDTAVAAARKLIDQDKVDAIVGPLSSGVAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 131 PAAEVASTRGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDA-ALARREGWNKVFVPTLDDPWATGIQQVFIAEF 209
Cdd:COG0683 86 AVAPVAEEAGVPLISPSATAPALTGPECSPYVFRTAPSDAQQAEALAdYLAKKLGAKKVALLYDDYAYGQGLAAAFKAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 210 TALGGEAVASV-YSGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSgwifpdglktqgFVDAvann 288
Cdd:COG0683 166 KAAGGEVVGEEyYPPGTTDFS-AQLTKIKAAGPDAVFLAGYGGDAALFIKQAREAGLKGP------------LNKA---- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 289 qylegalgtvpatlgadwtvFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSdDPNDRTQVRDNLAKTKtgqeihpg 368
Cdd:COG0683 229 --------------------FVKAYKAKY-GREPSSYAAAGYDAALLLAEAIEKA-GSTDREAVRDALEGLK-------- 278
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1278626266 369 ewskvlehladgslnYEGASGAVDLDANGDVTANVEEWTIE-NGAIKSV 416
Cdd:COG0683 279 ---------------FDGVTGPITFDPDGQGVQPVYIVQVKaDGKFVVV 312
|
|
| PBP1_ABC_LivK_ligand_binding-like |
cd06347 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
60-398 |
5.61e-53 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380570 [Multi-domain] Cd Length: 334 Bit Score: 180.05 E-value: 5.61e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 60 GAWAV-GDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVAST 138
Cdd:cd06347 10 GEAAAyGQPALNGAELAVDEINAAGGILGKKIELIVYDNKSDPTEAANAAQKLIDEDKVVAIIGPVTSSIALAAAPIAQK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 139 RGLVMVAPGATSPAITdlADNGWVSRTAPSDAQQGVVDAALARRE-GWNKVFVPT-LDDPWATGIQQVFIAEFTALGGEA 216
Cdd:cd06347 90 AKIPMITPSATNPLVT--KGGDYIFRACFTDPFQGAALAKFAYEElGAKKAAVLYdVSSDYSKGLAKAFKEAFEKLGGEI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 217 VASV-YSGTDANFaQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSgWIFPDGLKTQGFVDAVANNqyLEGAL 295
Cdd:cd06347 168 VAEEtYTSGDTDF-SAQLTKIKAANPDVIFLPGYYEEAALIIKQARELGITAP-ILGGDGWDSPELLELGGDA--VEGVY 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 296 GTVPATLGADWTV---FRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDpNDRTQVRDNLAKTKtgqeihpgewsk 372
Cdd:cd06347 244 FTTHFSPDDPSPEvqeFVKAYKAKY-GEPPNAFAALGYDAVMLLADAIKRAGS-TDPEAIRDALAKTK------------ 309
|
330 340
....*....|....*....|....*.
gi 1278626266 373 vlehladgslNYEGASGAVDLDANGD 398
Cdd:cd06347 310 ----------DFEGVTGTITFDPNGN 325
|
|
| PBP1_ABC_LIVBP-like |
cd06342 |
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active ... |
52-401 |
5.03e-51 |
|
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); This subgroup includes the type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few.
Pssm-ID: 380565 [Multi-domain] Cd Length: 334 Bit Score: 175.02 E-value: 5.03e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPyeGAWA-VGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTST--VSATTCcmrSAA 128
Cdd:cd06342 4 VAGPLT--GPNAaLGQDIRNGAELAVDEINAKGGGLGFKIELVAQDDACDPAQAVAAAQKLVADGVvaVIGHYN---SGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 129 TIPAAEVASTRGLVMVAPGATSPAITDLADNGwVSRTAPSDAQQGVVDAALARREGWNK-VFVptLDD--PWATGIQQVF 205
Cdd:cd06342 79 AIAAAPIYAEAGIPMISPSATNPKLTEQGYKN-FFRVVGTDDQQGPAAADYAAKTLKAKrVAV--IHDgtAYGKGLADAF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 206 IAEFTALGGEAVASVY-SGTDANFAQtIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTpSGWIFPDGLKTQGFVDA 284
Cdd:cd06342 156 KKALKALGGTVVGREGiTPGTTDFSA-LLTKIKAANPDAVYFGGYYPEAGLLLRQLREAGLK-APFMGGDGIVSPDFIKA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 285 VAnnQYLEGALGT---VPATLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDPnDRTQVRDNLAKTKt 361
Cdd:cd06342 234 AG--DAAEGVYATtpgAPPEKLPAAKAFLKAYKAKF-GEPPGAYAAYAYDAAQVLLAAIEKAGST-DRAAVAAALRATD- 308
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1278626266 362 gqeihpgewskvlehladgslnYEGASGAVDLDANGDVTA 401
Cdd:cd06342 309 ----------------------FDGVTGTISFDAKGDLTG 326
|
|
| PBP1_ABC_ligand_binding-like |
cd19984 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
55-337 |
3.99e-48 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380639 [Multi-domain] Cd Length: 296 Bit Score: 166.24 E-value: 3.99e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 55 PLPYEGAwAVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSA--TTCCmrSAATIPA 132
Cdd:cd19984 7 PLTGDAA-SYGEDMKNGIELAVEEINAAGGINGKKIELIYEDSKCDPKKAVSAANKLINVDKVKAiiGGVC--SSETLAI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 133 AEVASTRGLVMVAPGATSPAITDLADngWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTAL 212
Cdd:cd19984 84 APIAEQNKVVLISPGASSPEITKAGD--YIFRNYPSDAYQGKVLAEFAYNKLYKKVAILYENNDYGVGLKDVFKKEFEEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 213 GGEAVASVYSGTDANFAQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSgWIFPDGLKTQGFVDAVANNqyLE 292
Cdd:cd19984 162 GGKIVASESFEQGETDFRTQLTKIKAANPDAIFLPGYPKEGGLILKQAKELGIKAP-ILGSDGFEDPELLEIAGEA--AE 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1278626266 293 GALGTVPA-TLGADWTVFRTTYQ-KFYPGVEPFSYAANAYDAIYLLA 337
Cdd:cd19984 239 GVIFTYPAfDDSSEKKQKFFFYRyKEKYGKEPDIYAALAYDAVMILA 285
|
|
| PBP1_ABC_transporter_LIVBP-like |
cd06268 |
periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the ... |
52-337 |
2.31e-44 |
|
periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily; Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.
Pssm-ID: 380492 [Multi-domain] Cd Length: 298 Bit Score: 156.33 E-value: 2.31e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPYEGAWA-VGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATI 130
Cdd:cd06268 2 IGVVVPLTGPYAdYGEEILRGVALAVEEINAAGGINGRKLELVIADDQGDPETAVAVARKLVDDDKVLAVVGHYSSSVTL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 131 PAAEVASTRGLVMVAPGATSPAITDlADNGWVSRTAPSDAQQGVVDAALARREG-WNKVFVPTLDDPWATGIQQVFIAEF 209
Cdd:cd06268 82 AAAPIYQEAGIPLISPGSTAPELTE-GGGPYVFRTVPSDAMQAAALADYLAKKLkGKKVAILYDDYDYGKSLADAFKKAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 210 TALGGEAVASVYSGTDANFAQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPsGWIFPDGLKTQGFVDAVANNq 289
Cdd:cd06268 161 KALGGEIVAEEDFPLGTTDFSAQLTKIKAAGPDVLFLAGYGADAANALKQARELGLKL-PILGGDGLYSPELLKLGGEA- 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1278626266 290 yLEGALGTVPATLGAD---WTVFRTTYQKFYpGVEPFSYAANAYDAIYLLA 337
Cdd:cd06268 239 -AEGVVVAVPWHPDSPdppKQAFVKAYKKKY-GGPPSWRAATAYDATQALA 287
|
|
| PBP1_ABC_HAAT-like |
cd06349 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
51-412 |
3.07e-43 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380572 [Multi-domain] Cd Length: 338 Bit Score: 154.65 E-value: 3.07e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 51 YVASPLPYEGAWA-VGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAAT 129
Cdd:cd06349 1 KIGVSGPLTGDNAeYGQQFKNGVELAVDEINAAGGVNGRKLELVVYDDQGDPKEAVNIAQKFVSDDKVVAVIGDFSSSCS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 130 IPAAEVASTRGLVMVAPGATSPAITDLADNGWvsRTAPSDAQQG--VVDAAlARREGWNKVFVPTLDDPWATGIQQVFIA 207
Cdd:cd06349 81 MAAAPIYEEAGLVQISPTASHPDFTKGGDYVF--RNSPTQAVEApfLADYA-VKKLGAKKIAIIYLNTDWGVSAADAFKK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 208 EFTALGGEAVAS-VYSGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSgWIFPDGLKTQGFVDAV- 285
Cdd:cd06349 158 AAKALGGEIVATeAYLPGTKDFS-AQITKIKNANPDAIYLAAYYNDAALIAKQARQLGWDVQ-IFGSSSLYSPEFIELAg 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 286 --ANNQYLegALGTVPATLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDpnDRTQVRDNLAKTKtgq 363
Cdd:cd06349 236 daAEGVYL--SSPFFPESPDPEVKEFVKAYKAKY-GEDPDDFAARAYDAVNILAEAIEKAGT--DREAIRDALANIK--- 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1278626266 364 eihpgewskvlehladgslNYEGASGAVDLDANGDVTANVEEWTIENGA 412
Cdd:cd06349 308 -------------------DFSGLTGTITFDENGDVLKSLTILVVKDGK 337
|
|
| PBP1_ABC_HAAT-like |
cd06344 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
71-400 |
1.19e-38 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380567 [Multi-domain] Cd Length: 332 Bit Score: 141.98 E-value: 1.19e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 71 GILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLVMVAPGATS 150
Cdd:cd06344 20 GVELAVEEINAAGGVLGRKIRLVEYDDEASVDKGLAIAQRFADNPDVVAVIGHRSSYVAIPASIIYERAGLLMLSPGATA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 151 PaitDLADNG--WVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVASV-YSGTDAN 227
Cdd:cd06344 100 P---KLTQHGfkYIFRNIPSDEDIARQLARYAARQGYKRIVIYYDDDSYGKGLANAFEEEARELGITIVDRRsYSSDEED 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 228 FaQTIIDEAMA-YGPDAVFLAGLEVDGAAIVRTAIDSGFTPSgwIF-PDGLKTQGFVDAVANNqylegALGTVPATL--- 302
Cdd:cd06344 177 F-RRLLSKWKAlDFFDAIFLAGSMPEGAEFIKQARELGIKVP--IIgGDGLDSPELIEIAGKA-----AEGVVVATVfdp 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 303 -GADWTV--FRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSddpndRTQVRDNLAKTktgqeIHPGEwskvlehlad 379
Cdd:cd06344 249 dDPRPEVraFVEAFRKKY-GREPDVWAAQGYDAVKLLAEAIEKA-----GSTVPAKIASA-----LRFLE---------- 307
|
330 340
....*....|....*....|.
gi 1278626266 380 gslNYEGASGAVDLDANGDVT 400
Cdd:cd06344 308 ---NWEGVTGTYSFDANGDVV 325
|
|
| PBP1_ABC_HAAT-like |
cd19988 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
57-337 |
1.09e-33 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380643 [Multi-domain] Cd Length: 302 Bit Score: 127.78 E-value: 1.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 57 PYEGAWAVGDQTE-PGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEV 135
Cdd:cd19988 7 PLSGDAAPYGQAMlQGAELAVEEINAAGGILGIPIELVVEDDEGLPAASVSAAKKLIYQDKVWAIIGSINSSCTLAAIRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 136 ASTRGLVMVAPGATSPAITDLAdNGWVSRTAPSDAQQG--VVDAAlARREGWNKVFVPTLDDPWATGIQQVFIAEFTALG 213
Cdd:cd19988 87 ALKAGVPQINPGSSAPTITESG-NPWVFRCTPDDRQQAyaLVDYA-FEKLKVTKIAVLYVNDDYGRGGIDAFKDAAKKYG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 214 GEAVAS-VYSGTDANF-AQ-TIIDEAmayGPDAVFLAGLEVDGAAIVRTAIDSGFTPsgWIF-PDGLKTQGFVDAVanNQ 289
Cdd:cd19988 165 IEVVVEeSYNRGDKDFsPQlEKIKDS---GAQAIVMWGQYTEGALIAKQARELGLKQ--PLFgSDGLVTPKFIELA--GD 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1278626266 290 YLEGALGTV---PATLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLA 337
Cdd:cd19988 238 AAEGAIATTpflPDSDDPKVSAFVEKYKKRY-GEEPDVFAAQAYDAMNILA 287
|
|
| PBP1_ABC_ligand_binding-like |
cd06340 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
52-373 |
2.90e-31 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380563 [Multi-domain] Cd Length: 352 Bit Score: 122.28 E-value: 2.90e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPYEGAWAV-GDQTEPGILIAIQEINAAGGVH---GKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSA 127
Cdd:cd06340 2 IGVLYPLSGPLALiGQEAKRGAELAVDEINAAGGIKslgGAKIELVVADTQSDPEVAASEAERLITQEGVVAIIGAYSSS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 128 ATIPAAEVASTRGLVMVAPGATSPAITdlaDNG--WVSRTAPSDAQQG------VVDAALARREGWNKVFVPTLDDPWAT 199
Cdd:cd06340 82 VTLAASQVAERYGVPFVTASAVADEIT---ERGfkYVFRTAPTASQFAedavdfLKELAKKKGKKIKKVAIIYEDSAFGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 200 GIQQVFIAEFTALGGEAVASV-YSGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSGWIFPD-GLK 277
Cdd:cd06340 159 SVAKGLKKAAKKAGLEVVLDEpYPAGATDLS-SEVLKLKAAKPDVVFATSYTNDAILLLRTMKELGFKPKAIIGVGgGYS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 278 TQGFVDAVANNqyLEGALGTVP-----ATLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDpNDRTQV 352
Cdd:cd06340 238 DPEFLKALGKD--AEGVFSVVPwspdlAKKKPGAKEVNERYKKKY-GEDMTGHAARAYTAAWVLADALERAGS-TDPEAI 313
|
330 340
....*....|....*....|.
gi 1278626266 353 RDNLAKTKTGQEIHPGEWSKV 373
Cdd:cd06340 314 RAAAALTLDIPEGLIMPGGGV 334
|
|
| PBP1_ABC_HAAT-like |
cd06348 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
65-411 |
3.51e-31 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380571 [Multi-domain] Cd Length: 342 Bit Score: 121.96 E-value: 3.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 65 GDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLVMV 144
Cdd:cd06348 16 GQSQKNGAQLAVEEINAAGGVGGVKIELIVEDTAGDPEQAINAFQKLINQDKVLAILGPTLSSEAFAADPIAQQAKVPVV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 145 APGATSPAITDLADngWVSRTAPSDAQQ--GVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVASV-Y 221
Cdd:cd06348 96 GISNTAPGITDIGP--YIFRNSLPEDKVipPTVKAAKKKYGIKKVAVLYDQDDAFTVSGTKVFPAALKKNGVEVLDTEtF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 222 SGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFT-----PSGWIFPDGLKTQGfvDAVannqylEGAL- 295
Cdd:cd06348 174 QTGDTDFS-AQLTKIKALNPDAIVISALAQEGALIVKQARELGLKgpivgGNGFNSPDLIKLAG--KAA------EGVIv 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 296 GTV--PATLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDPNDRTQVRDNLAKTKTgqeihpgewskv 373
Cdd:cd06348 245 GSAwsPDNPDPKNQAFVAAYKEKY-GKEPDQFAAQAYDAAYILAEAIKKAGSTTDRADLRDALARILI------------ 311
|
330 340 350
....*....|....*....|....*....|....*...
gi 1278626266 374 lehladgSLNYEGASGAVDLDANGDVTANVEEWTIENG 411
Cdd:cd06348 312 -------AKDFEGPLGPFSFDADRDGIQPPVVLIVKDG 342
|
|
| Peripla_BP_6 |
pfam13458 |
Periplasmic binding protein; This family includes a diverse range of periplasmic binding ... |
63-360 |
1.78e-30 |
|
Periplasmic binding protein; This family includes a diverse range of periplasmic binding proteins.
Pssm-ID: 433225 [Multi-domain] Cd Length: 342 Bit Score: 120.07 E-value: 1.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 63 AVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLV 142
Cdd:pfam13458 16 SSGKSSRAGARAAIEEINAAGGVNGRKIELVVADDQGDPDVAAAAARRLVDQDGVDAIVGGVSSAVALAVAEVLAKKGVP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 143 MVAPGATSPAITdladNGWVSRTAPSDAQQGVVDA-ALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVASV- 220
Cdd:pfam13458 96 VIGPAALTGEKC----SPYVFSLGPTYSAQATALGrYLAKELGGKKVALIGADYAFGRALAAAAKAAAKAAGGEVVGEVr 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 221 YSGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSGW------IFPDGLKTQGfvdavanNQYLEGA 294
Cdd:pfam13458 172 YPLGTTDFS-SQVLQIKASGADAVLLANAGADTVNLLKQAREAGLDAKGIklvglgGDEPDLKALG-------GDAAEGV 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1278626266 295 LGTVPATLGADWTV---FRTTYQKFYPGVEPFSYAANAYDAIYLLAIAMELSDDPnDRTQVRDNLAKTK 360
Cdd:pfam13458 244 YATVPFFPDLDNPAtraFVAAFAAKYGEAPPTQFAAGGYIAADLLLAALEAAGSP-TREAVIAALRALP 311
|
|
| PBP1_ABC_RPA1789-like |
cd06333 |
type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, ... |
60-360 |
3.05e-30 |
|
type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs; This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Pssm-ID: 380556 [Multi-domain] Cd Length: 342 Bit Score: 119.57 E-value: 3.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 60 GAWAVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTR 139
Cdd:cd06333 11 PAASLGIPERNAVELLVEQINAAGGINGRKLELIVYDDESDPTKAVTNARKLIEEDKVDAIIGPSTTGESLAVAPIAEEA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 140 GLVMVAPGATSpAITDlADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVAS 219
Cdd:cd06333 91 KVPLISLAGAA-AIVE-PVRKWVFKTPQSDSLVAEAILDYMKKKGIKKVALLGDSDAYGQSGRAALKKLAPEYGIEIVAD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 220 -VYSGTDANF-AQtiIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTpsGWIFPD-GLKTQGFVD---AVANNQYLEG 293
Cdd:cd06333 169 eRFARTDTDMtAQ--LTKIRAAKPDAVLVWASGPPAALVAKNLRQLGYK--GPIYQShGAANQDFIKlagKAAEGVILPA 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1278626266 294 ALGTVPATLGADWTV------FRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDPnDRTQVRDNLAKTK 360
Cdd:cd06333 245 GKLLVADQLPDSDPQkkvlleFVKAYEAKY-GEGPSTFAGHAYDALLLLVEAIEPAGGT-DRAALRDALENTK 315
|
|
| ANF_receptor |
pfam01094 |
Receptor family ligand binding region; This family includes extracellular ligand binding ... |
67-400 |
1.91e-29 |
|
Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.
Pssm-ID: 460062 [Multi-domain] Cd Length: 347 Bit Score: 117.49 E-value: 1.91e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 67 QTEPGILIAIQEINAAGGVHGKP-LGLVVCNTKGDGTVATQIMNELADTSTVS--ATTCcmrSAATIPAAEVASTRGLVM 143
Cdd:pfam01094 1 LVLLAVRLAVEDINADPGLLPGTkLEYIILDTCCDPSLALAAALDLLKGEVVAiiGPSC---SSVASAVASLANEWKVPL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 144 VAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGGE--AVASVY 221
Cdd:pfam01094 78 ISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDYGESGLQALEDALRERGIRvaYKAVIP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 222 SGTDANFAQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSG--WIFPDGLKTQGFVDAVANNQYLEGALGTVP 299
Cdd:pfam01094 158 PAQDDDEIARKLLKEVKSRARVIVVCCSSETARRLLKAARELGMMGEGyvWIATDGLTTSLVILNPSTLEAAGGVLGFRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 300 ATlgADWTVFRTTYQKFYP---------GVEPFSYAANAYDAIYLLAIAMElsddpndrtQVRDNLAKTKTGQEIHP-GE 369
Cdd:pfam01094 238 HP--PDSPEFSEFFWEKLSdekelyenlGGLPVSYGALAYDAVYLLAHALH---------NLLRDDKPGRACGALGPwNG 306
|
330 340 350
....*....|....*....|....*....|.
gi 1278626266 370 WSKVLEHLADgsLNYEGASGAVDLDANGDVT 400
Cdd:pfam01094 307 GQKLLRYLKN--VNFTGLTGNVQFDENGDRI 335
|
|
| PBP1_ABC_ligand_binding-like |
cd19980 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
56-361 |
6.97e-29 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380635 [Multi-domain] Cd Length: 334 Bit Score: 115.40 E-value: 6.97e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 56 LPYEGAWAV-GDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAE 134
Cdd:cd19980 6 APLSGPVAAlGQQVLNGAKLAVEEINAKGGVLGRKLELVVEDDKCPPAEGVAAAKKLITDDKVPAIIGAWCSSVTLAVMP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 135 VASTRGLVMVAPGATSPAITDlADNGWVSRTAPSDAQQGVVDAA-LARREGWNKVFVPTLDDPWATGIQQVFIAEFTALG 213
Cdd:cd19980 86 VAERAKVPLVVEISSAPKITE-GGNPYVFRLNPTNSMLAKAFAKyLADKGKPKKVAFLAENDDYGRGAAEAFKKALKAKG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 214 GEAVASVY-SGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSG-----FTPSGWIFPDGLKTQGfvDAvan 287
Cdd:cd19980 165 VKVVATEYfDQGQTDFT-TQLTKLKAANPDAIFVVAETEDGALILKQARELGlkqqlVGTGGTTSPDLIKLAG--DA--- 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278626266 288 nqyLEGALGTVP--ATLGADW-TVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDPNDRTQVRDNLAKTKT 361
Cdd:cd19980 239 ---AEGVYGASIyaPTADNPAnKAFVAAYKKKY-GEPPDKFAALGYDAVMVIAEAIKKAGSTDPEKIRAAALKKVDY 311
|
|
| PBP1_ABC_ligand_binding-like |
cd06335 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
71-361 |
3.41e-28 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380558 [Multi-domain] Cd Length: 348 Bit Score: 113.86 E-value: 3.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 71 GILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLVMVAPGATS 150
Cdd:cd06335 22 GVELAVEEINAAGGILGRKIELVERDDEANPTKAVQNAQELIDKEKVVAIIGPTNSGVALATIPILQEAKIPLIIPVATG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 151 PAITDLADNG--WVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVASvysgtdANF 228
Cdd:cd06335 102 TAITKPPAKPrnYIFRVAASDTLQADFLVDYAVKKGFKKIAILHDTTGYGQGGLKDVEAALKKRGITPVAT------ESF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 229 AQTIID------EAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTP---SGWifpdGLKTQGFVDAVANNqyLEGALGTVP 299
Cdd:cd06335 176 KIGDTDmtpqllKAKDAGADVILVYGLGPDLAQILKAMEKLGWKVplvGSW----GLSMPNFIELAGPL--AEGTIMTQT 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1278626266 300 atlgADWTVFRTTYQKFY---------PGVEPFSYAANAYDAIYLLAIAMELSDDpNDRTQVRDNLAKTKT 361
Cdd:cd06335 250 ----FIEDYLTPRAKKFIdaykkkygtDRIPSPVSAAQGYDAVYLLAAAIKQAGS-TDGKKIRAALENLKG 315
|
|
| PBP1_ABC_ligand_binding-like |
cd06345 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
52-341 |
2.10e-27 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380568 [Multi-domain] Cd Length: 356 Bit Score: 111.97 E-value: 2.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPYegawAVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIP 131
Cdd:cd06345 4 VLGPLSA----PAGEAMERGAELAVEEINAAGGILGRKVELVVADTQGKPEDGVAAAERLITEDKVDAIVGGFRSEVVLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 132 AAEVASTRGLVMVAPGATSPAITDL-----ADNGWVSRTAP--SDAQQGVVDAA---LARREGWNKVFVPTLDDPWATGI 201
Cdd:cd06345 80 AMEVAAEYKVPFIVTGAASPAITKKvkkdyEKYKYVFRVGPnnSYLGATVAEFLkdlLVEKLGFKKVAILAEDAAWGRGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 202 QQVFIAEFTALGGEAVASVYSGTDANFAQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTP------SGWIFPDG 275
Cdd:cd06345 160 AEALKKLLPEAGLEVVGVERFPTGTTDFTPILSKIKASGADVIVTIFSGPGGILLVKQWAELGVPAplvginVPAQDPEF 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278626266 276 LK-TQGFVDAVAnnqYLEGALGTVPATlgaDWTV-FRTTYQKFYpGVEPFSYAANAYDAIYLLAIAME 341
Cdd:cd06345 240 WEnTGGAGEYEI---TLAFAAPKAKVT---PKTKpFVDAYKKKY-GEAPNYTAYTAYDAIYILAEAIE 300
|
|
| PBP1_ABC_HAAT-like |
cd19983 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
71-337 |
5.05e-26 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380638 [Multi-domain] Cd Length: 303 Bit Score: 106.90 E-value: 5.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 71 GILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTStVSATTCCMRSAATIPAAEVASTRGLVMVAPGATS 150
Cdd:cd19983 22 GAQLAVEEINAAGGINGRPVELIIRDDQQDPEAAKAADRELIAGG-VVAIIGHMTSAMTVAVLPVINEAKVLMISPTVST 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 151 PAITDLADngWVSRTAPSDAQQGVVDAALARREGWNK---VFVPTLDDPWATGIQQVFIAEFTALGGEAVASVY--SGTD 225
Cdd:cd19983 101 PELSGKDD--YFFRVTPTTRESAQALARYAYNRGGLRrvaVIYDLSNRAYSESWLDNFRSEFEALGGRIVAEIPfsSGAD 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 226 ANFaQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTP----SGWIFPDGLKTQGfvdavanNQYLEGALGTV--- 298
Cdd:cd19983 179 VDF-SDLARRLLASKPDGLLLVASAVDTAMLAQQIRKLGSKIplfsSAWAATEELLELG-------GKAVEGMLFSQayd 250
|
250 260 270
....*....|....*....|....*....|....*....
gi 1278626266 299 PATLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLA 337
Cdd:cd19983 251 RNSSNPRYLAFKEAYEERF-GREPSFAAAYAYEAAMVLA 288
|
|
| PBP1_ABC_ligand_binding-like |
cd06338 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
60-361 |
1.42e-25 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380561 [Multi-domain] Cd Length: 347 Bit Score: 106.51 E-value: 1.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 60 GAWAV-GDQTEPGILIAIQEINAAGGVHG----KPLGLVVCNTKGDGTVATQIMNELADTSTV----SATTccmrSAATI 130
Cdd:cd06338 10 GPFAGeGKAQKRGYELWVEDVNAAGGVKGggkkRPVELVYYDDQSDPATAVRLYEKLITEDKVdlllGPYS----SGLTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 131 PAAEVASTRGLVMVAPGATSPAITDlADNGWVSRTAP--SDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAE 208
Cdd:cd06338 86 AAAPVAEKYGIPMIAGGAASDSIFE-RGYKYVFGVLPpaSDYAKGLLDLLAELGPKPKTVAIVYEDDPFGKEVAEGAREA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 209 FTALGGEAVAS-VYSGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSGWIFPDGLKTQGFVDAVAN 287
Cdd:cd06338 165 AKKAGLEVVYDeSYPPGTTDFS-PLLTKVKAANPDILLVGGYPPDAITLVRQMKELGYNPKAFFLTVGPAFPAFREALGK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 288 NqyLEGALGTVPATLGADWTVFRTT------YQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDPnDRTQVRDNLAKTKT 361
Cdd:cd06338 244 D--AEGVLGPSQWEPSLPYKVFPGAkefvkaYKEKF-GEEPSYHAAAAYAAGQVLQQAIEKAGSL-DPEKVRDALASLDF 319
|
|
| PBP1_ABC_HAAT-like |
cd19986 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
63-337 |
3.71e-25 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380641 [Multi-domain] Cd Length: 297 Bit Score: 104.25 E-value: 3.71e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 63 AVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLV 142
Cdd:cd19986 14 LNGEYQKNGAQLALEEINAAGGVLGRPLELVVEDDQGTNTGAVNAVNKLISDDKVVAVIGPHYSTQVLAVSPLVKEAKIP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 143 MVApGATSPAITDLaDNGWVSRTAPSDAQQGVVDAALARRE-GWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVASV- 220
Cdd:cd19986 94 VIT-GGTSPKLTEQ-GNPYMFRIRPSDSVSAKALAKYAVEElGAKKIAILYDNDDFGTGGADVVTAALKALGLEPVAVEs 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 221 YSGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSG-----FTPSGWIFPDGLKTQGfvdavannQYLEGAL 295
Cdd:cd19986 172 YNTGDKDFT-AQLLKLKNSGADVIIAWGHDAEAALIARQIRQLGldvpvIGSSSFATPTVLLLAG--------EALEGIY 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1278626266 296 GTVPATLGAD---WTVFRTTYQKFYpGVEPFSYAANAYDAIYLLA 337
Cdd:cd19986 243 SVTDFVPSDPdpkVQAFVKKYKAKY-GEDPDLYSAWYYDAMYLLA 286
|
|
| PBP1_ABC_HAAT-like |
cd19985 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
49-337 |
7.02e-22 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380640 [Multi-domain] Cd Length: 321 Bit Score: 95.42 E-value: 7.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 49 YYYVASPLPYEGAwAVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVsATTCCMRSAA 128
Cdd:cd19985 1 HIAVVGPMSGKSA-SKGKSMLRGAELYIDQINAAGGINGKKVKLDVFDDQNDPDAARKAAQIIVSDKAL-AVIGHYYSSA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 129 TIPAAEVASTRGLVMVAPGATSPAITdlADNGWVSRTAPSDAQQGVVDAALARRE-GWNKVFVPTLDDPWATGIQQVFIA 207
Cdd:cd19985 79 SIAAGKIYKKAGIPAITPSATADAVT--RDNPWYFRVIFNDSLQGRFLANYAKKVlKKDKVSIIYEEDSYGKSLASVFEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 208 EFTALGGE-----AVASVYSGTDANFAQTIID-EAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSgWIFPDGLKTQGF 281
Cdd:cd19985 157 TARALGLKvlkkwSFDTDSSQLDQNLDQIVDElKKAPDEPGVIFLATHADEGAKLIKKLRDAGLKAP-IIGPDSLASESF 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278626266 282 VDAVANNQ--------YLEGALGTVP---ATLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLA 337
Cdd:cd19985 236 AQGFAEYPeekeepgyYTDGIYATSPfifDIANEKAQKFRDTYQKRY-GEEPSWIAAFAYDAAMLAI 301
|
|
| PBP1_ABC_ligand_binding-like |
cd06336 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
74-360 |
1.63e-21 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380559 [Multi-domain] Cd Length: 345 Bit Score: 94.99 E-value: 1.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 74 IAIQEINAAGG--VHGKP--LGLVVCNTKGDGTVATQIMNELADTSTVSATtCCMRSAATIPAAEVASTRGLVMVAPGAT 149
Cdd:cd06336 25 LAADEINAAGGikVGGKKykVEVVSYDDKYTPAEAVAAARRLVSQDGVKFI-FGPGGSAIAAAVQPVTERNKVLLLTAAF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 150 SPAITDlADNGWVSRTAPSDAQQGVVDAALARREGWNK--VFVPTLD-DPWATGiqQVFIAEFTALGGEAVAS-VYSGTD 225
Cdd:cd06336 104 SDPILG-PDNPLLFRIPPTPYEYAPPFIKWLKKNGPIKtvALIAPNDaTGKDWA--AAFVAAWKAAGGEVVAEeFYDRGT 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 226 ANFaQTIIDEAMAYGPDAVFLAGL-EVDGAAIVRTAIDSGFTPsGWIFPDGLKTQGFVdAVANNQYLEGALGTVPA---- 300
Cdd:cd06336 181 TDF-YPVLTKILALKPDALDLGGSsPGPAGLIIKQARELGFKG-PFVSEGGAKADEIL-KEVGGEAAEGFIGVLPAdddp 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 301 TLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSDDPNDRTQVRDNLAKTK 360
Cdd:cd06336 258 IASPGAKAFVERYKKKY-GEPPNSESALFYDAAYILVKAMEKAGTVDDTKKIRAALAMLS 316
|
|
| PBP1_ABC_HAAT-like |
cd19981 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
71-337 |
4.11e-21 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380636 [Multi-domain] Cd Length: 297 Bit Score: 92.74 E-value: 4.11e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 71 GILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLVMVAPGATS 150
Cdd:cd19981 22 GAELAVEQINAAGGINGKKVELVVYDDQASPKQAVNIAQKLIEQDKVVAVVSGSYSGPTRAAAPIFQEAKVPMVSAYAVH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 151 PAITdlADNGWVSRTAPSDAQQGVVDAALARRE-GWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVA-SVYSGTDANF 228
Cdd:cd19981 102 PDIT--KAGDYVFRVAFLGPVQGRAGAEYAVKDlGAKKVAILTIDNDFGKSLAAGFKEEAKKLGAEIVSeYAYALGDRDF 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 229 aQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTpsGWIF-PDGLKTQGFVDavANNQYLEGALGTVPATLGADwt 307
Cdd:cd19981 180 -RPILTKIKSANPDAIYASGYYAEAAPIVKQARELGIK--VPIIgQEGYDSPKFIE--IAGSAAEGVIITTSLNRDSD-- 252
|
250 260 270
....*....|....*....|....*....|....*.
gi 1278626266 308 vfRTTYQKF------YPGVEPFSYAANAYDAIYLLA 337
Cdd:cd19981 253 --RPITQKFikeyrkRYGIDPDMVAASTYDAVMVLA 286
|
|
| PBP1_SBP-like |
cd19989 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
52-337 |
1.19e-20 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380644 [Multi-domain] Cd Length: 299 Bit Score: 91.57 E-value: 1.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPYEGAWAV-GDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATI 130
Cdd:cd19989 2 IGVLTPLSGPYAAlGEEARRGAQLAVEEINAAGGILGRPVELVVEDTEGKPATAVQKARKLVEQDGVDFLTGAVSSAVAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 131 PAAEVASTRGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFT 210
Cdd:cd19989 82 AVAPKAAELKVPYLVTVAADDELTGENCNRYTFRVNTSDRMIARALAPWLAENGGKKWYIVYADYAWGQSSAEAFKEAIE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 211 ALGGEAVASVYS--GTDaNFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSG-------FTPSGWIFPDGLKTQGf 281
Cdd:cd19989 162 ELGGEVVGTLFAplGTT-DFS-SYITQISDSGADGLLLALAGSDAVNFLKQAGQFGlgkkykiVGGILSIEPLALPALG- 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1278626266 282 vDAVannqylEGALGTV--PATLGADWTVFRTTYQKFYPGVEPFSYAANAYDAIYLLA 337
Cdd:cd19989 239 -DAA------EGVYGGVryPPTLDTPANRAFVEAYEKEYGEAPDNFAGEAYEAMQALA 289
|
|
| PBP1_As_SBP-like |
cd06330 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
52-341 |
1.33e-19 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea that is predicted to be involved in the efflux of toxic compounds. Members of this subgroup include proteins from Herminiimonas arsenicoxydans, which is resistant to arsenic (As) and various heavy metals such as cadmium and zinc. Moreover, they show significant sequence similarity to the cluster of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa.
Pssm-ID: 380553 [Multi-domain] Cd Length: 342 Bit Score: 89.16 E-value: 1.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPYEGAWAV-GDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATI 130
Cdd:cd06330 2 IGVITPLSGAAAVyGEPARNGAELAVEEINAAGGILGRKIELVVRDDKGKPDEAVRAARELVLQEGVDFLIGTISSGVAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 131 PAAEVASTRGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALA--RREGWNKVFVPTLDDPWATGIQQVFIAE 208
Cdd:cd06330 82 AVAPVAEELKVLFIATDAATDRLTEENFNPYVFRTSPNTYMDAVAAALYAakKPPDVKRWAGIGPDYEYGRDSWAAFKAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 209 FTALGGEA--VASVYSGTDANFAQTIIDEAMAYGPDAVF--LAGleVDGAAIVRTAIDSG-FTPSGWIFPDGLktqGFVD 283
Cdd:cd06330 162 LKKLKPDVevVGELWPKLGATDYTAYITALLAAKPDGVFssLWG--GDLVTFVKQAKPYGlFDKTKVVSGLGG---GSEV 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1278626266 284 AVA-NNQYLEGALGTVPATLGADWT----VFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAME 341
Cdd:cd06330 237 LQAlGKEMPEGLIGGGRYPFGWPDTplnkAFVEAYRAKY-GEYPTYWAYEAYAAVMALKAAIE 298
|
|
| PBP1_AmiC-like |
cd06331 |
type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system ... |
52-357 |
3.39e-19 |
|
type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); This group includes the type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF), found in bacteria and Archaea. AmiC controls expression of the amidase operon by a ligand-triggered conformational switch. In the absence of ligand or presence of butyramide (repressor), AmiC (the ligand sensor and negative regulator) adopts an open conformation and inhibits the transcription antitermination function of AmiR by direct protein-protein interaction. In the presence of inducing ligands such as acetamide, AmiC adopts a closed conformation which disrupts a silencing AmiC-AmiR complex and the expression of amidase and other genes of the operon is induced. FmdDEF is predicted to be an ATP-dependent transporter and closely resembles the periplasmic binding protein and the two transmembrane proteins present in various hydrophobic amino acid-binding transport systems.
Pssm-ID: 380554 [Multi-domain] Cd Length: 333 Bit Score: 88.04 E-value: 3.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 52 VASPLPYEGAWAV-GDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATI 130
Cdd:cd06331 2 IGLLTPLSGPASVyGRAIANGAELAVEEINAAGGVLGRPVELVVEDDASDPATAVAAARRLIQQDKVDAIVGPITSATRN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 131 PAAEVASTRGLVMVAP-----GATSPaitdladngWVSRTAPSDAQQgvVDAALAR--REGWNKVFVPTLDDPWATGIQQ 203
Cdd:cd06331 82 AVAPVAERAKVPLLYPtfyegGECSP---------YLFCFGEVPNQQ--LDPLIPWlmEEYGKKFYLIGSDYVWPRTMND 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 204 VFIAEFTALGGEAVASVYSGTDANFAQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSGwifpdglktqgfvd 283
Cdd:cd06331 151 AARRVIEAHGGEVVGEEYLPLGTTDFSSVIEKIKASGADVVLSTLVGADAVTFLKQFAAAGLRRKV-------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 284 AVANNQYLEGALGTVPATLGAD-WTV--------------FRTTYQKFYPGVEPF--SYAANAYDAIYLLAIAMELSDDP 346
Cdd:cd06331 217 RIAALLFDENTLAGLGAEAAEGiYSVlsyfqsldtpenkaFVAAYRKKFGEDAPPitSLSEAAYEAVHLYAAAVEKAGST 296
|
330
....*....|.
gi 1278626266 347 nDRTQVRDNLA 357
Cdd:cd06331 297 -DPEAVIAALP 306
|
|
| PBP1_ABC_ligand_binding-like |
cd19979 |
amino acid amide ABC transporter substrate binding protein haat family; This subgroup includes ... |
63-341 |
1.97e-17 |
|
amino acid amide ABC transporter substrate binding protein haat family; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380634 [Multi-domain] Cd Length: 350 Bit Score: 83.04 E-value: 1.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 63 AVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLV 142
Cdd:cd19979 14 ASGEAIKRGIQLAIDEINAAGGLLGRKLELVAKDHRGNPARGVDNLREFAADPDVLAVFGGLHSPVLLAELDFIHELKIP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 143 MVAPGATSPAITDL-ADNGWVSRTAPSDAQQG--VVDAALARREGwnKVFVPTLDDPWATGIQQVFIAEFTALGGEAVAS 219
Cdd:cd19979 94 YLVPWAAATPITRNgYSPNYIFRLSVDDSLAGpfLVEYALKKGCK--RPALLLENTGWGRSNLKAMTKALAKKGLQPVGV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 220 VYSGTDANFAQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTP--------SGWIFPDG------------LKTQ 279
Cdd:cd19979 172 EWFNWGDTDAKPQLRALKAAGADAILLVANAPEGAAIVKALAALPERLpiishwgiTGGDFPELprealskidlrfIQTF 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278626266 280 GFVDAVANNQylegalgtvpatlGADwtVFrTTYQKFYPGVEPFSY------AANAYDAIYLLAIAME 341
Cdd:cd19979 252 SFFDANQSPR-------------GKQ--VL-ARYKRRYPVEDPESDipapvgFAHAYDLTHLLALAIE 303
|
|
| PBP1_ABC_ligand_binding-like |
cd06341 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
75-360 |
7.75e-16 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380564 [Multi-domain] Cd Length: 340 Bit Score: 78.12 E-value: 7.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 75 AIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSA---TTccmrSAATIPAAEVASTRGL-VMVAPGATS 150
Cdd:cd06341 26 RFGLANAAGGINGRKVEYVWCDDQSDPATNLQAARQLVEDEKVFAlvgSS----SAASGSANDYLAQAGIpVVGGAGVSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 151 PAITDLADNGWVSRTAPSDaqqgVVDAALARREGWNKVFVPTLDDP-WATGIQQVFIAEFTALGGEAVAS-VYSGTDANF 228
Cdd:cd06341 102 WCFRNMFSNFFSLGGGGST----TTYGQYAAALGGTKAAVVVTDIPaASQQLAQQLAASLRAAGVEVVGTaPYAAAAPDY 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 229 AQtIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSGWIFPDGLKTQgfvDAVANNQYLEGALGTVPATL----GA 304
Cdd:cd06341 178 TA-VAQAAKAAGADAVVGVLDPDVAARVLKAARAQGLDLKVALSPSGYDPS---VLAAYGAALAGVSVASTFLPfeadTP 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1278626266 305 DWTVFRTTYQKFYPGVEPF--SYAANAYDAIYLLAIAMELSDDPNDRTQVRDNLAKTK 360
Cdd:cd06341 254 AVKAYRAAMAKYAPELQDPlqQFALSGYIAADLFVRGLEAAGGCPTRAAFIKALRDVK 311
|
|
| PBP1_GABAb_receptor |
cd06366 |
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for ... |
51-417 |
6.02e-15 |
|
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.
Pssm-ID: 380589 [Multi-domain] Cd Length: 404 Bit Score: 76.13 E-value: 6.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 51 YVASPLPYEG--AWAVGDQTEPGILIAIQEINAAGGVH-GKPLGLVVCNTKGDGTVATQIMNELADTSTvsatTCCM--- 124
Cdd:cd06366 1 YIGGLFPLSGskGWWGGAGILPAAEMALEHINNRSDILpGYNLELIWNDTQCDPGLGLKALYDLLYTPP----PKVMllg 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 125 --RSAATIPAAEVASTRGLVMVAPGATSPAitdLADNG---WVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWAT 199
Cdd:cd06366 77 pgCSSVTEPVAEASKYWNLVQLSYAATSPA---LSDRKrypYFFRTVPSDTAFNPARIALLKHFGWKRVATIYQNDEVFS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 200 GIQQVFIAEFTALGGEAVASVYsgtdanFAQTIIDEAMA--YGPDA--VFLAGLEVDGAAIVRTAIDSGFTPSG--WIFP 273
Cdd:cd06366 154 STAEDLEELLEEANITIVATES------FSSEDPTDQLEnlKEKDAriIIGLFYEDAARKVFCEAYKLGMYGPKyvWILP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 274 DGLkTQGFVDAVANN---------QYLEGALGTVPATLGADWTV---------FRTTYQK--FYPGVEPFSYAANAYDAI 333
Cdd:cd06366 228 GWY-DDNWWDVPDNDvnctpeqmlEALEGHFSTELLPLNPDNTKtisgltaqeFLKEYLErlSNSNYTGSPYAPFAYDAV 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 334 YLLAIAMELSDDPNDRTQVR---DNLAKTKTGQEIhpgewskvLEHLadGSLNYEGASGAVDLDANGDVTANVEEWTIEN 410
Cdd:cd06366 307 WAIALALNKTIEKLAEYNKTledFTYNDKEMADLF--------LEAM--NSTSFEGVSGPVSFDSKGDRLGTVDIEQLQG 376
|
....*..
gi 1278626266 411 GAIKSVG 417
Cdd:cd06366 377 GSYVKVG 383
|
|
| PBP1_aromatic_compounds-like |
cd06332 |
type 1 periplasmic binding proteins of active transport systems predicted to be involved in ... |
56-360 |
3.89e-14 |
|
type 1 periplasmic binding proteins of active transport systems predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; This group includes the type 1 periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; their substrate specificities are not well characterized, however. Members also exhibit close similarity to active transport systems for short chain amides and/or urea found in bacteria and archaea.
Pssm-ID: 380555 [Multi-domain] Cd Length: 336 Bit Score: 73.02 E-value: 3.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 56 LPYEGAWAV-GDQTEPGILIAIQEINaaGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAE 134
Cdd:cd06332 6 APLTGPFAAlGEDMVRGFELALEEVG--GEVAGRKVELVVEDDAGDPDTAVTKARKLVEQDKVDVLIGPLSGDEGLAVAP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 135 VASTRGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARRE-GWNKVFvpTLDDPWATGIQQV--FIAEFTA 211
Cdd:cd06332 84 YAKEPGVPFINPVAGADDLTQRAKAPNFFRTSFTGSQWSAPLGDYAYKElGYKKVA--TIGSDYAFGYEQAagFKRGFEA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 212 LGGEAVASVYS--GTD--ANFAQTIIDEAmaygpDAVFLAGLEVDGAAIVRTAIDSGFTPSGWIFPdglkTQGFVDAVAN 287
Cdd:cd06332 162 AGGEVVQEIWVplGTTdfSPYIAQIPSAD-----DAVFAFLGGADAVRFLKQYREFGLKDKIPLIG----GGTTVDESVL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 288 NQYLEGALGTVPATL------GADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAMELSD-DPNDRTQVRDNLAKTK 360
Cdd:cd06332 233 PAMGDAALGIISASHyaegldNPENKKFVAAYKKKF-GKLPSLYAAGGYDGAQAILEALEAVGgDVSDKQALAAALRKVK 311
|
|
| PBP1_ABC_ligand_binding-like |
cd06326 |
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to ... |
56-268 |
5.77e-14 |
|
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally, however.
Pssm-ID: 380549 [Multi-domain] Cd Length: 339 Bit Score: 72.57 E-value: 5.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 56 LPYEGAWA-VGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAE 134
Cdd:cd06326 7 APLSGPLAeLGREYLAGAKAYFDQVNAAGGINGRKIRLVTLDDGYDPARTVENTRQLIEQDKVVALFGYVGTANVEAVLP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 135 VASTRGLVMVAPGATSPAITDlADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGG 214
Cdd:cd06326 87 LLEEAGVPLVGPLTGADSLRE-PGNPYVFHVRASYADEVEKIVRHLATLGLKRIAVVYQDDPFGKEGLAAAEAALAARGL 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1278626266 215 EAVASV-YSGTDANFAQtIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPS 268
Cdd:cd06326 166 EPVATAaVARNAADVAA-AAAALAAAKPQAVVLIAAGKAAAAFIKALRAAGGAAQ 219
|
|
| PBP1_ABC_ligand_binding-like |
cd19982 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
55-337 |
4.31e-13 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380637 [Multi-domain] Cd Length: 302 Bit Score: 69.62 E-value: 4.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 55 PLPYEGAWAV-GDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAA 133
Cdd:cd19982 5 ILSLTGPFAPfGEMFKNGYEMALEEINAAGGIKGKKLELVIEDDQSKPQTALAAAEKLVSQDKVPLIVGGYSSGITLPVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 134 EVASTRGLVMVAPGATSPAITDlADNGWVSRT-APSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTAL 212
Cdd:cd19982 85 AVAERQKIPLLVPTAADDDITK-PGYKYVFRLnPPASIYAKALFDFFKELVKPKTIAILYENTAFGTSVAKAARRFAKKR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 213 GGEAVASV-YSGTDANFaQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSGWI-FPDGLKTQGFVDAV---AN 287
Cdd:cd19982 164 GIEVVADEsYDKGATDF-KPLLNKVKAANPDVVYMVSYLNDAILLMRQAKELGLNPKLFAgGGAGFTIPEFLKQAgplAE 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1278626266 288 NqylegalgTVPATLGAD---WTVFRTTYQKF--YPGVEPFSYAANAYDAIYLLA 337
Cdd:cd19982 243 Y--------VVTATLWSPdvkYPGAKEFYEKYkaKYGVEPSYHEAEAYAALYVAA 289
|
|
| PBP1_glutamate_receptors-like |
cd06269 |
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl ... |
51-335 |
5.40e-13 |
|
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as natriuretic peptide receptors (NPRs), and N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of ionotropic glutamate rece; This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the ionotropic glutamate receptors, all of which are structurally similar and related to the periplasmic-binding fold type 1 family. The family C GPCRs consists of metabotropic glutamate receptor (mGluR), a calcium-sensing receptor (CaSR), gamma-aminobutyric acid receptor (GABAbR), the promiscuous L-alpha-amino acid receptor GPR6A, families of taste and pheromone receptors, and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids, ions, and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors, AMPA receptors, and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B), the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E, GC-F), and olfactory receptors (GC-D and GC-G).
Pssm-ID: 380493 [Multi-domain] Cd Length: 332 Bit Score: 69.37 E-value: 5.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 51 YVASPLPYEGAWAVGDQTEPGILIAIQEINAAG-GVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSA--TTCCmrSA 127
Cdd:cd06269 1 TIGALLPVHDYLESGAKVLPAFELALSDVNSRPdLLPKTTLGLAIRDSECNPTQALLSACDLLAAAKVVAilGPGC--SA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 128 ATIPAAEVASTRGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIA 207
Cdd:cd06269 79 SAAPVANLARHWDIPVLSYGATAPGLSDKSRYAYFLRTVPPDSKQADAMLALVRRLGWNKVVLIYSDDEYGEFGLEGLEE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 208 EFTALGGEAVA--SVYSGTDANFAQtIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSG--WIFPDGL--KTQGF 281
Cdd:cd06269 159 LFQEKGGLITSrqSFDENKDDDLTK-LLRNLRDTEARVIILLASPDTARSLMLEAKRLDMTSKDyvWFVIDGEasSSDEH 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1278626266 282 VDAVanNQYLEGALGT------VPATLGADWTVFRTTYQKF---YPGVEPFSYAANAYDAIYL 335
Cdd:cd06269 238 GDEA--RQAAEGAITVtlifpvVKEFLKFSMELKLKSSKRKqglNEEYELNNFAAFFYDAVLA 298
|
|
| PRK15404 |
PRK15404 |
high-affinity branched-chain amino acid ABC transporter substrate-binding protein; |
65-173 |
7.11e-13 |
|
high-affinity branched-chain amino acid ABC transporter substrate-binding protein;
Pssm-ID: 237959 [Multi-domain] Cd Length: 369 Bit Score: 69.66 E-value: 7.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 65 GDQTEPGILIAIQEINAAGGVHGKPLGLVV----CNTKGDGTVATQIMNElaDTSTVSATTCcmrSAATIPAAEVASTRG 140
Cdd:PRK15404 42 GDMEFTGARQAIEDINAKGGIKGDKLEGVEyddaCDPKQAVAVANKVVND--GIKYVIGHLC---SSSTQPASDIYEDEG 116
|
90 100 110
....*....|....*....|....*....|...
gi 1278626266 141 LVMVAPGATSPAITDLADNgWVSRTAPSDAQQG 173
Cdd:PRK15404 117 ILMITPAATAPELTARGYQ-LIFRTIGLDSDQG 148
|
|
| PBP1_ABC_ligand_binding-like |
cd06343 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
63-341 |
1.38e-12 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Pssm-ID: 380566 [Multi-domain] Cd Length: 355 Bit Score: 68.36 E-value: 1.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 63 AVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLV 142
Cdd:cd06343 21 AYGKPVRAGAAAYFDEVNAAGGINGRKIELIVEDDGYDPARAVAAVRKLVEQDKVFAIVGGLGTPTNLAVRPYLNEAGVP 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 143 MVAPGATSPAITDlADNGWVSRTAPSDAQQGVVDAALARREGWN-KVFVPTLDDPWATGIQQVFIAEFTALGGEAVASV- 220
Cdd:cd06343 101 QLFPATGASALSP-PPKPYTFGVQPSYEDEGRILADYIVETLPAaKVAVLYQNDDFGKDGLEGLKEALKAYGLEVVAEEt 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 221 YSGTDANFAqTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSgWIFPDGLKTQGFVDAVAnNQYLEGALGT--- 297
Cdd:cd06343 180 YEPGDTDFS-SQVLKLKAAGADVVVLGTLPKEAAAALKEAAKLGWKPT-FLGSSVSADPTTLAKAG-GDAAEGVYSAsyl 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1278626266 298 VPATLGADWTV--FRTTYQKFYPGVEPFSYAANAYDAIYLLAIAME 341
Cdd:cd06343 257 KDPTDADDPAVkeFREAYKKYFPDDPPNAYALYGYAAAQVFVEALK 302
|
|
| PBP1_ABC_transporter_GPCR_C-like |
cd04509 |
Family C of G-protein coupled receptors and their close homologs, the type 1 ... |
65-313 |
5.41e-09 |
|
Family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems; This CD includes members of the family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor, G-protein-coupled receptors, metabotropic glutamate, GABA-B, calcium sensing, pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels, iGluR, can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate), AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid), and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem, a LIVBP-like domain that constitutes the N terminus (included in this model) followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type 2 periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are also included in this family.
Pssm-ID: 380490 Cd Length: 306 Bit Score: 57.31 E-value: 5.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 65 GDQTEPGILIAIQEINAAG-GVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCC-------------------- 123
Cdd:cd04509 26 GIQRFEAMEQALDDINADPnLLPNNTLGIVIYDDCCDPKQALEQSNKFVNDLIQKDTSDVrctngeppvfvkpegikgvi 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 124 --MRSAATIPAAEVASTRGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGI 201
Cdd:cd04509 106 ghLCSSVTIPVSNILELFGIPQITYAATAPELSDDRGYQLFLRVVPLDSDQAPAMADIVKEKVWQYVSIVHDEGQYGEGG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 202 QQVFiAEFTALGGEAVA---SVYSGTDANFAQTIIDEAMAYGP-DAVFLAGLEVDGAAIVRTAIDSGFTP-SGWIFPDGL 276
Cdd:cd04509 186 ARAF-QDGLKKGGLCIAfsdGITAGEKTKDFDRLVARLKKENNiRFVVYFGYHPEMGQILRAARRAGLVGkFQFMGSDGW 264
|
250 260 270
....*....|....*....|....*....|....*..
gi 1278626266 277 KTQGFVDAVANNQyLEGALGTVPATlgadWTVFRTTY 313
Cdd:cd04509 265 ANVSLSLNIAEES-AEGLITIKPKV----WFVIAALY 296
|
|
| PBP1_GPCR_family_C-like |
cd06350 |
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ... |
75-334 |
1.33e-08 |
|
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.
Pssm-ID: 380573 Cd Length: 350 Bit Score: 56.15 E-value: 1.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 75 AIQEINAAGGVH-GKPLGLVVCNTKGDGTVAT-QIMNELADTSTVSATTCC---------------MRSAATIPAAEVAS 137
Cdd:cd06350 36 AIEEINNDSSLLpNVTLGYDIRDTCSSSSVALeSSLEFLLDNGIKLLANSNgqnigppnivavigaASSSVSIAVANLLG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 138 TRGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGG--E 215
Cdd:cd06350 116 LFKIPQISYASTSPELSDKIRYPYFLRTVPSDTLQAKAIADLLKHFNWNYVSTVYSDDDYGRSGIEAFEREAKERGIciA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 216 AVASVYSGTDANFAQTIIDE-AMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSGWIFPDGLkTQGFVDAVANNQYLEGA 294
Cdd:cd06350 196 QTIVIPENSTEDEIKRIIDKlKSSPNAKVVVLFLTESDARELLKEAKRRNLTGFTWIGSDGW-GDSLVILEGYEDVLGGA 274
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1278626266 295 LGTVPATlgadwtvfrTTYQKFYPGVEpfSYAANAYDAIY 334
Cdd:cd06350 275 IGVVPRS---------KEIPGFDDYLK--SYAPYVIDAVY 303
|
|
| PBP1_SBP-like |
cd06329 |
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
63-348 |
2.05e-08 |
|
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380552 [Multi-domain] Cd Length: 343 Bit Score: 55.74 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 63 AVGDQTEPGILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELAD-------TSTVSATTccmrsAATIPAAEV 135
Cdd:cd06329 14 SVGEIYLKGLQFAIEEINAGGGLLGRKIELVPFDNKGSPQEALIQLKKAIDqgirfvlQGNSSAVA-----GALIDAIEK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 136 ASTRG----LVMVAPGATSPAITDLADNGWVSRTapsDAQQGVVDAALAR----REGWNKVFVPTLDDPWATGIQQVFIA 207
Cdd:cd06329 89 HNQRNpdkrVLFLNYGAEAPELTGAKCSFWHFRF---DANADMKMAALADymkkDGSIKKVYLINQDYSFGRDVAAAAKK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 208 EFTALG------GEAVASVYSGTDanFAQTiIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGF-TPSGWIFPDGLKTQG 280
Cdd:cd06329 166 NLKKKRpdieivGEDLHPLGKVKD--FSPY-IAKIKASGADTVITGNWGNDLTLLMKAARDSGLkAPFYTYYADGPGAPA 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 281 FVDAVANNQYLeGALGTVPATLGADWTVFRTTYQKFYPGVEPFSYaANAYDAIYLLAIAMEL--SDDPND 348
Cdd:cd06329 243 AIGEAGVGRLV-AVAYWHPNPKTPELEKFAEAFRAKYGRYPDFNI-GRTYMGVEMLAAAIKKagSTDPEK 310
|
|
| PBP1_SBP-like |
cd06328 |
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
65-247 |
8.75e-08 |
|
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in gram-negative and gram-positive bacteria. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380551 [Multi-domain] Cd Length: 336 Bit Score: 53.46 E-value: 8.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 65 GDQTEPGILIAIQEinAAGG---VHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGL 141
Cdd:cd06328 16 GKQTERGFELGLEY--ATDGtmeVDGRKIEVIVKDDQGDPDTAKAAATELIGDDGVDILVGTVSSAVALALAPVAEQNKK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 142 VMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVASVY 221
Cdd:cd06328 94 ILIVGPAAADSITGENWNKYTFRTSRNSWQDAIAGAKALADPLGKSVAFLAQDYAFGQDGVAAFKKALEAKGGKIVGEEL 173
|
170 180
....*....|....*....|....*.
gi 1278626266 222 SGTDANFAQTIIDEAMAYGPDAVFLA 247
Cdd:cd06328 174 VPVTTTDFTPYLQRILDAKPDVLFVA 199
|
|
| PBP1_SBP-like |
cd19987 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
57-341 |
1.06e-07 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380642 [Multi-domain] Cd Length: 353 Bit Score: 53.49 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 57 PYEGAWAV-GDQTEPGILIAIQEINAAG------------GVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCC 123
Cdd:cd19987 7 PLSGPYAPqGEDQRRGFELAVDHLNNGGglvdkdsrlsgdGILGKKVELVTADTETKADTAVDNAKRLIEQDGAVMITGG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 124 MRSAATIPAAEVASTRGLVMVAPGATSPAIT---------DLADNGWVSRTApsdaqqgVVDAALARREGWNKVFVPTLD 194
Cdd:cd19987 87 SSSAVAVAAQKLAQKEGVLYFAGLSHSNDTTgkdchrygfRECFNAHMSAKA-------LAPYLVEKFGKDRKYFYLTAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 195 DPWATGIQQVFIAEFTALGGEAVASVYSGTDANFAQTIIDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPS-GWIFP 273
Cdd:cd19987 160 YTWGHSTEQSMREYTEAHGWKTVGNPATPLGETDFSAALLNAADSGADVLVLVLFGRDMVNALKQAKQFGLLKKmDIVVP 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1278626266 274 dgLKTQGFVDAVAnNQYLEGALGTVP-----ATLGADWTVFRTTYQKFYpGVEPFSYAANAYDAIYLLAIAME 341
Cdd:cd19987 240 --LLTAFMAESVG-PEIMEGVLGTVNwhwslPDDYSYAFGKAEAFEKEY-GAYPSQAAASAYVQVLQYAAAVE 308
|
|
| PBP1_RPA0985_benzoate-like |
cd20013 |
type 1 periplasmic binding-protein component of an ABC system (RPA0985), involved in the ... |
56-264 |
1.90e-07 |
|
type 1 periplasmic binding-protein component of an ABC system (RPA0985), involved in the active transport of lignin-derived benzoate derivative compounds, and its close homologs; This group includes RPA0985 from Rhodopseudomonas palustris and its close homologs in other bacteria. Rpa0985 is the periplasmic binding-protein component of an ABC system that is involved in the active transport of lignin-derived benzoate derivative compounds. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Pssm-ID: 380666 [Multi-domain] Cd Length: 356 Bit Score: 52.64 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 56 LPYEGAWAV-GDQTEPGILIAIQEinaaggvHGKPLG-----LVVCNTKG-DGTVATQIMNELADTSTVSATTCCMRSAA 128
Cdd:cd20013 6 GPFSGPFADyGKQFDRGIDLYLKL-------HGDKVGgrkveVIYRDDGGpNPAVAKRLAQELIVRDKVQILIGFGFTPN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 129 TIPAAEVASTRGLVMVAPGATSPAITDLADngWVSRTAPSDAQQGVVDAALARREGWNKVFVPTLDdpWATGI--QQVFI 206
Cdd:cd20013 79 ALAVAPVATEAKTPTVIMNAATSSITRKSP--YFVRTSFTMWQVAYPMGKWAAKNGIKKAYTAVAD--YAPGHdaETAFK 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278626266 207 AEFTALGGEAVASV---YSGTD-ANFAQTIIDEamayGPDAVFL---AGleVDGAAIVRTAIDSG 264
Cdd:cd20013 155 KAFEAAGGKIVGSIrvpLATPDfAPFMQRIKDA----KPDAVFVfvpAG--APSIGFLKAYAERG 213
|
|
| PBP1_NPR_GC-like |
cd06352 |
ligand-binding domain of membrane guanylyl-cyclase receptors; Ligand-binding domain of ... |
65-398 |
2.14e-06 |
|
ligand-binding domain of membrane guanylyl-cyclase receptors; Ligand-binding domain of membrane guanylyl-cyclase receptors. Membrane guanylyl cyclases (GC) have a single membrane-spanning region and are activated by endogenous and exogenous peptides. This family can be divided into three major subfamilies: the natriuretic peptide receptors (NPRs), sensory organ-specific membrane GCs, and the enterotoxin/guanylin receptors. The binding of peptide ligands to the receptor results in the activation of the cytosolic catalytic domain. Three types of NPRs have been cloned from mammalian tissues: NPR-A/GC-A, NPR-B/ GC-B, and NPR-C. In addition, two of the GCs, GC-D and GC-G, appear to be pseudogenes in humans. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are produced in the heart, and both bind to the NPR-A. NPR-C, also termed the clearance receptor, binds each of the natriuretic peptides and can alter circulating levels of these peptides. The ligand binding domain of the NPRs exhibits strong structural similarity to the type 1 periplasmic binding fold protein family.
Pssm-ID: 380575 [Multi-domain] Cd Length: 391 Bit Score: 49.66 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 65 GDQTEPGILIAIQEINAAGGVHgkPLGLVVCNTKGDGTVATQIMNELAD---TSTVSA---TTCcmrSAATIPAAEVAST 138
Cdd:cd06352 17 YARSAPAIDIAIERINSEGLLL--PGFNFEFTYRDSCCDESEAVGAAADliyKRNVDVfigPAC---SAAADAVGRLATY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 139 RGLVMVAPGATSPAITDLADNGWVSRTAPSDAQQGVVDAALARREGWNKVFV--PTLDDPWATgIQQVFIAEFTALGGEA 216
Cdd:cd06352 92 WNIPIITWGAVSASFLDKSRYPTLTRTSPNSLSLAEALLALLKQFNWKRAAIiySDDDSKCFS-IANDLEDALNQEDNLT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 217 VASV--YSGTDANFAQTIIDEAMAYGpdAVFLAGLEVDgaaIVRT----AIDSGFTPSG--WIFPDGLKTQGFVDAVANN 288
Cdd:cd06352 171 ISYYefVEVNSDSDYSSILQEAKKRA--RIIVLCFDSE---TVRQfmlaAHDLGMTNGEyvFIFIELFKDGFGGNSTDGW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 289 -----------QYLEGALG-TVPATLGADWTVFRT----------TYQKFYPGVEPFSYAANAYDAIYLLAIAME--LSD 344
Cdd:cd06352 246 erndgrdedakQAYESLLViSLSRPSNPEYDNFSKevkarakeppFYCYDASEEEVSPYAAALYDAVYLYALALNetLAE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1278626266 345 DPNdrtqVRDNLAKTKtgqeihpgewskvleHLADGSlnYEGASGAVDLDANGD 398
Cdd:cd06352 326 GGN----YRNGTAIAQ---------------RMWNRT--FQGITGPVTIDSNGD 358
|
|
| PBP1_FmdD-like |
cd06355 |
periplasmic component (FmdD) of an active transport system for short-chain amides and urea ... |
72-245 |
8.24e-06 |
|
periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); This group includes the periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF), found in Methylophilus methylotrophus, and its homologs from other bacteria. FmdD, a type 1 periplasmic binding protein, is induced by short-chain amides and urea and repressed by excess ammonia, while FmdE and FmdF are hydrophobic transmembrane proteins. FmdDEF is predicted to be an ATP-dependent transporter and closely resembles the periplasmic binding protein and the two transmembrane proteins present in various hydrophobic amino acid-binding transport systems.
Pssm-ID: 380578 [Multi-domain] Cd Length: 347 Bit Score: 47.57 E-value: 8.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 72 ILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSA---ATIPAAEvasTRGLVMVAPGA 148
Cdd:cd06355 23 TLLAIDEINAAGGLLGRKIEPVIEDGASDWPTFAEKAEKLITQDKVAVIFGCWTSAsrkAVLPVIE---KYNGLLFYPVQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 149 -----TSPAITdladngwvsRTAPSDAQQGVVDAALARREGWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVASVYSG 223
Cdd:cd06355 100 yegleQSPNIV---------YTGATPNQQILPAIDWLLENLGKRFFLVGSDYVFPRTANKIIRDQLKALGGEVVGEEYVP 170
|
170 180
....*....|....*....|..
gi 1278626266 224 TDANFAQTIIDEAMAYGPDAVF 245
Cdd:cd06355 171 LGGTDFDAIVAKIKAFKPDVIV 192
|
|
| PBP1_AmiC |
cd06357 |
periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding ... |
71-356 |
1.11e-05 |
|
periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding fold protein family; This group includes the periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding fold protein family. AmiC controls expression of the amidase operon by the ligand-triggered conformational switch. In the absence of ligand or presence of butyramide (repressor), AmiC (the ligand sensor and negative regulator) adopts an open conformation and inhibits the transcription antitermination function of AmiR by direct protein-protein interaction. In the presence of inducing ligands such as acetamide, AmiC adopts a closed conformation which disrupts a silencing AmiC-AmiR complex and the expression of amidase and other genes of the operon are induced.
Pssm-ID: 380580 [Multi-domain] Cd Length: 357 Bit Score: 47.19 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 71 GILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSA---ATIPAAEvasTRGLVMVAP- 146
Cdd:cd06357 22 GALLAIEEINAAGGVNGRPIEPVVYDPASDPDRYRELAERLLLEDGVRHIFGCYTSAsrkAVLPVVE---RHNALLWYPt 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 147 ---G-ATSPaitdladNgwVSRTAPSDAQQGVvdaALAR---REGWNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVAS 219
Cdd:cd06357 99 pyeGfEYSP-------N--VIYTGAVPNQHLL---PLARyllAHFGKRVFLVGSNYVYPWESNRVARELIEASGGEVVGE 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 220 VY--SGTDAnFAQtIIDEAMAYGPDAVF--LAGleVDGAAIVRTAIDSGFTPSGWIFPDGLKTQGFVDAVAnNQYLEGAL 295
Cdd:cd06357 167 RYvpLGDTD-FAE-IIEEIKSLKPDVVFstLVG--DSIYAFYRAYAEAGLDPADMPIASLTTSEAEVAAIG-AEAAAGHY 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278626266 296 GTVP--ATLGADWTV-FRTTYQKFY-PGVEPFSYAANAYDAIYLLAIAMELSDDPnDRTQVRDNL 356
Cdd:cd06357 242 TSAPyfQSIDTPENRaFVEAYRARFgDDAVTSAVAEAAYFQVHLLARAIERAGSD-DPEAIRAAL 305
|
|
| PBP1_YraM_LppC_lipoprotein-like |
cd06339 |
periplasmic binding component of lipoprotein LppC, an immunodominant antigen; This subgroup ... |
125-399 |
1.27e-05 |
|
periplasmic binding component of lipoprotein LppC, an immunodominant antigen; This subgroup includes periplasmic binding component of lipoprotein LppC, an immunodominant antigen, whose molecular function is not characterized. Members of this subgroup are predicted to be involved in transport of lipid compounds, and they are sequence similar to the family of ABC-type hydrophobic amino acid transporters (HAAT).
Pssm-ID: 380562 [Multi-domain] Cd Length: 331 Bit Score: 46.88 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 125 RSAATIPAAEVASTRGLVMVAPGATSPAITDladnGWVSRTAPSDAQQGVVDAALARREGWNK--VFVPtlDDPWATGIQ 202
Cdd:cd06339 68 LKSSVAALAAAAQALGVPVLALNNDESATAG----PGLFQFGLSPEDEARQAARYAVQQGLRRfaVLAP--DNAYGQRVA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 203 QVFIAEFTALGGEAVASV-YSGTDANFAQTI---------------------IDEAMAYGPDAVFLAGLEVDGAAIVR-- 258
Cdd:cd06339 142 NAFREAWQALGGTVVAVEsYDPDETDFSAAIrrllgvdqsearirqlgelleFEPRRRQDFDAIFLPAGPEQARLIAPql 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 259 TAIDSG----FTPSGWifpdglkTQGFVDAVANnQYLEGA-LGTVPATLGADWTVFRttYQKFYpGVEPFSYAANAYDAI 333
Cdd:cd06339 222 AFYGAGdvplLGTSLW-------YSGKLNLLRD-PDLNGAwFADPPWLLSPRAFPLR--YRLAY-GWPPPRLAALGYDAY 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278626266 334 yllAIAMELSDdpndrtqvrdnlaktkTGQEIHPGewskvlehladgsLNYEGASGAVDLDANGDV 399
Cdd:cd06339 291 ---RLAARLAR----------------LGGGLTPG-------------AGFSGLTGLLRLDPDGRI 324
|
|
| PBP1_ABC_ligand_binding-like |
cd19978 |
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to ... |
71-149 |
4.30e-05 |
|
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally, however.
Pssm-ID: 380633 [Multi-domain] Cd Length: 341 Bit Score: 45.26 E-value: 4.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 71 GILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLVMVAP--GA 148
Cdd:cd19978 23 GIEAAFNEVNAQGGVNGRKIKLIALDDGYEPDRTVKNTKKLIEEDKVFALIGYVGTPTALAALPLANEKKIPLFGPftGA 102
|
.
gi 1278626266 149 T 149
Cdd:cd19978 103 E 103
|
|
| PBP1_Nba-like |
cd06359 |
type 1 periplasmic binding component of active transport systems predicted to be involved in ... |
63-360 |
3.37e-04 |
|
type 1 periplasmic binding component of active transport systems predicted to be involved in 2-nitrobenzoic acid degradation pathway; This group includes the type 1 periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; their substrate specificities are not well characterized.
Pssm-ID: 380582 [Multi-domain] Cd Length: 333 Bit Score: 42.63 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 63 AVGDQTEPGILIAIQEINaaGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAATIPAAEVASTRGLV 142
Cdd:cd06359 14 VLGQDMRDGFNLALEQLG--GKLGGLPVEVVVEDDQLKPDVAKQAAERLIERDKVDFVTGIIFSNVMLAVVKPVVDSKVF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 143 MVAPGATsPAitDLADNG----WVSRTAPSDAQQGVVdAALARREGWNKVFVPTLDDP----WATGIQQVFiaeftalGG 214
Cdd:cd06359 92 YISANAG-PS--DLAGKGcnpnFFVTSWQNDQLHEAA-GKYANDKGYKRVYLLAPNYQagkdALAGFKRTY-------KG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 215 EAVASVYSG-TDANFAQTIiDEAMAYGPDAVFLAGLEVDGAAIVRTAIDSGFTPSgwifpDGLKTQGFVD------AVAn 287
Cdd:cd06359 161 EVVGEIYTPlGQLDFSAEL-AQIRAAKPDAVFAFYPGGMGVNFVKQYAQAGLKKK-----IPLYTVGTLDdedllpAMG- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 288 nqylEGALGTVpatLGADWTV---------FRTTYQKFYpGVEPFSYAANAYDAIYLLAIAM-ELSDDPNDRTQVRDNLA 357
Cdd:cd06359 234 ----DAALGVL---SVSQWSPdldnpenkrFVAAFRKKY-GRPPSNYAAQGYDAALLIDAAVkAVGGDLSDKDALRAALR 305
|
...
gi 1278626266 358 KTK 360
Cdd:cd06359 306 KAD 308
|
|
| Peripla_BP_5 |
pfam13433 |
Periplasmic binding protein domain; This domain is found in a variety of bacterial periplasmic ... |
71-267 |
5.84e-04 |
|
Periplasmic binding protein domain; This domain is found in a variety of bacterial periplasmic binding proteins.
Pssm-ID: 463875 [Multi-domain] Cd Length: 363 Bit Score: 41.81 E-value: 5.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 71 GILIAIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSA---ATIPAAEvaSTRGLvMVAPG 147
Cdd:pfam13433 23 ATLMAIEEINAAGGVLGRKIEPVVVDPASDWPLFAEKARKLIDQDKVRVVFGCWTSAsrkAVLPVFE--RHNGL-LFYPV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 148 A-----TSPAI--TDLADNgwvsrtapsdaqQGVVDAA--LARREGwNKVFVPTLDDPWATGIQQVFIAEFTALGGEAVA 218
Cdd:pfam13433 100 QyegfeSSRNIfyTGAAPN------------QQAIPAVdyLLSELG-KRFFLVGSDYVYPRTTNRILRAYLKAKGGEVVG 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1278626266 219 SVYSGTDANFAQTIIDEAMAYGPDAVF--LAGlevDG-AAIVRTAIDSGFTP 267
Cdd:pfam13433 167 ERYLPLGSSDWQSIVAKIKAAGPDVVFstING---DSnVAFYRALRAAGITA 215
|
|
| PBP1_ABC_sugar_binding-like |
cd06316 |
periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Periplasmic ... |
191-296 |
8.47e-04 |
|
periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.
Pssm-ID: 380539 [Multi-domain] Cd Length: 294 Bit Score: 41.07 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278626266 191 PTLDDPWATGIQQVFIAEFTALGGEAVASVYSGTDANFAQTIIDEAMAYGPDAVFlaGLEVDG---AAIVRTAIDSGFTp 267
Cdd:cd06316 7 HTTGSDWSRLQVAGIKDTFEELGIEVVAVTDANFDPAKQITDLETLIALKPDIII--SIPVDPvatAAAYKKVADAGIK- 83
|
90 100 110
....*....|....*....|....*....|....
gi 1278626266 268 sgWIF----PDGLKTQG-FVDAVANNQYLEGALG 296
Cdd:cd06316 84 --LVFmdnvPDGLEAGKdYVSVVSSDNRGNGQIA 115
|
|
| PBP1_amide_urea_BP-like |
cd06356 |
periplasmic component (FmdD) of an active transport system for short-chain amides and urea ... |
75-128 |
2.25e-03 |
|
periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); This group includes the type 1 periplasmic-binding proteins that are predicted to have a function similar to that of an active transport system for short chain amides and/or urea in bacteria and Archaea, by sequence comparison and phylogenetic analysis.
Pssm-ID: 380579 [Multi-domain] Cd Length: 334 Bit Score: 39.98 E-value: 2.25e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1278626266 75 AIQEINAAGGVHGKPLGLVVCNTKGDGTVATQIMNELADTSTVSATTCCMRSAA 128
Cdd:cd06356 26 AVEEINAAGGLLGRQIELVAYDTQSDMQKYTQYAQQLILRDKVDVVFGGITSAS 79
|
|
| |
