NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1278750146|gb|PJC47189.1|]
View 

ribose-phosphate pyrophosphokinase, partial [Candidatus Omnitrophica bacterium CG_4_9_14_0_2_um_filter_42_8]

Protein Classification

ribose-phosphate pyrophosphokinase-like domain-containing protein( domain architecture ID 10619030)

ribose-phosphate pyrophosphokinase-like domain-containing protein which contains the N-terminal domain of ribose-phosphate pyrophosphokinase and phosphoribosyl pyrophosphate synthetase-associated proteins, which play roles in 5-phospho-ribosyl-1(alpha)-pyrophosphate (PRPP) synthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-100 5.32e-69

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 201.49  E-value: 5.32e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100
                  ....*....|....*....|
gi 1278750146  81 RITAVLPYFGYARQDRKDQP 100
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKP 100
 
Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-100 5.32e-69

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 201.49  E-value: 5.32e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100
                  ....*....|....*....|
gi 1278750146  81 RITAVLPYFGYARQDRKDQP 100
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKP 100
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-100 2.32e-67

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 204.14  E-value: 2.32e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:COG0462     4 LKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRASAR 83

                          90       100
                  ....*....|....*....|
gi 1278750146  81 RITAVLPYFGYARQDRKDQP 100
Cdd:COG0462    84 RITAVIPYYGYARQDRKFRP 103
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-100 3.43e-67

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 203.81  E-value: 3.43e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:PRK01259    1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                          90       100
                  ....*....|....*....|
gi 1278750146  81 RITAVLPYFGYARQDRKDQP 100
Cdd:PRK01259   81 RITAVIPYFGYARQDRKARS 100
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-100 1.13e-50

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 161.68  E-value: 1.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFII-QPTCPPVNDNLMELLILIDALKRASA 79
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100
                  ....*....|....*....|.
gi 1278750146  80 KRITAVLPYFGYARQDRKDQP 100
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKS 101
 
Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-100 5.32e-69

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 201.49  E-value: 5.32e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100
                  ....*....|....*....|
gi 1278750146  81 RITAVLPYFGYARQDRKDQP 100
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKP 100
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-100 2.32e-67

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 204.14  E-value: 2.32e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:COG0462     4 LKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRASAR 83

                          90       100
                  ....*....|....*....|
gi 1278750146  81 RITAVLPYFGYARQDRKDQP 100
Cdd:COG0462    84 RITAVIPYYGYARQDRKFRP 103
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-100 3.43e-67

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 203.81  E-value: 3.43e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:PRK01259    1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                          90       100
                  ....*....|....*....|
gi 1278750146  81 RITAVLPYFGYARQDRKDQP 100
Cdd:PRK01259   81 RITAVIPYFGYARQDRKARS 100
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-100 1.13e-50

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 161.68  E-value: 1.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFII-QPTCPPVNDNLMELLILIDALKRASA 79
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100
                  ....*....|....*....|.
gi 1278750146  80 KRITAVLPYFGYARQDRKDQP 100
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKS 101
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 10-99 6.89e-48

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 154.08  E-value: 6.89e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146  10 PKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAKRITAVLPYF 89
Cdd:PLN02369    1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80

                          90
                  ....*....|
gi 1278750146  90 GYARQDRKDQ 99
Cdd:PLN02369   81 GYARADRKTQ 90
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
3-97 6.56e-47

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 152.39  E-value: 6.56e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   3 IIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAKRI 82
Cdd:PRK04923    9 VFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRASAASV 88

                          90
                  ....*....|....*
gi 1278750146  83 TAVLPYFGYARQDRK 97
Cdd:PRK04923   89 TAVIPYFGYSRQDRR 103
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 1-97 2.54e-44

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 145.66  E-value: 2.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:PRK02812   22 LRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASAR 101

                          90
                  ....*....|....*..
gi 1278750146  81 RITAVLPYFGYARQDRK 97
Cdd:PRK02812  102 QITAVIPYYGYARADRK 118
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 3-97 3.85e-40

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 137.31  E-value: 3.85e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   3 IIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAKRI 82
Cdd:PTZ00145  122 LFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRASAKKI 201

                          90
                  ....*....|....*
gi 1278750146  83 TAVLPYFGYARQDRK 97
Cdd:PTZ00145  202 TAVIPYYGYARQDRK 216
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
1-97 1.06e-39

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 133.76  E-value: 1.06e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:PRK02269    6 LKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASAE 85

                          90
                  ....*....|....*..
gi 1278750146  81 RITAVLPYFGYARQDRK 97
Cdd:PRK02269   86 SINVVMPYYGYARQDRK 102
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-100 1.72e-38

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 130.63  E-value: 1.72e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   1 MKIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAK 80
Cdd:PRK02458   10 IKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRASAN 89

                          90       100
                  ....*....|....*....|
gi 1278750146  81 RITAVLPYFGYARQDRKDQP 100
Cdd:PRK02458   90 TVNVVLPYFGYARQDRIAKP 109
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 3-97 3.12e-38

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 130.04  E-value: 3.12e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   3 IIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAKRI 82
Cdd:PRK00553   12 IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSI 91

                          90
                  ....*....|....*
gi 1278750146  83 TAVLPYFGYARQDRK 97
Cdd:PRK00553   92 TAILPYYGYARQDRK 106
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
12-97 1.92e-37

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 127.37  E-value: 1.92e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146  12 LAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPVNDNLMELLILIDALKRASAKRITAVLPYFGY 91
Cdd:PRK03092    1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80


                  ....*.
gi 1278750146  92 ARQDRK 97
Cdd:PRK03092   81 ARQDKK 86
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 2-97 6.08e-28

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 102.30  E-value: 6.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   2 KIIAGNANPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQpTCPPVNDNLMELLILIDALKRASAKR 81
Cdd:PRK00934    1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIIS-TTYPQDENLVELLLLIDALRDEGAKS 79

                          90
                  ....*....|....*.
gi 1278750146  82 ITAVLPYFGYARQDRK 97
Cdd:PRK00934   80 ITLVIPYLGYARQDKR 95
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 32-98 1.24e-13

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 64.59  E-value: 1.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146  32 FSEGEIRVKIDENVRGRDVFIIQPTCP--------------PVNDNLMELLILIDALkRASAKRITAVLPYFGYARQDRK 97
Cdd:PRK06827   62 FSNGEAKGEILESVRGKDIYILQDVGNysvtynmfgeknhmSPDDHFQDLKRTIDAI-RGKARRITVIMPFLYESRQHKR 140


                  .
gi 1278750146  98 D 98
Cdd:PRK06827  141 K 141
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
9-100 1.95e-13

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 63.80  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278750146   9 NPKLAQEICKYLKIPLADALVATFSEGEIRVKIDENVRGRDVFIIQPTCPPvNDNLMELLILIDALKRASAKRITAVLPY 88
Cdd:PRK07199   11 NEAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLDRP-DEKLLPLLFAAEAARELGARRVGLVAPY 89

                          90
                  ....*....|..
gi 1278750146  89 FGYARQDRKDQP 100
Cdd:PRK07199   90 LAYMRQDIAFHP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH