|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
3-469 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 785.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 3 RRLRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFK 82
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 83 EGKVFLNIGDKFLLDANlGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGI 162
Cdd:PRK05826 81 EGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 163 NKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGC-DAKIVAKVERAEAVcdqDAMDDVIL 241
Cdd:PRK05826 160 NIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAV---DNIDEIIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 242 ASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAET 321
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 322 AAGQYPAETVAAMARVCLGAEKIPSINVSKHRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSG 401
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPG 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278866048 402 LPIFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIG 469
Cdd:PRK05826 397 APIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
4-479 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 724.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 4 RLRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKE 83
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 84 GKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGIN 163
Cdd:COG0469 81 GPVELKKGDTFTLTTD--DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 164 KLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcdqDAMDDVILAS 243
Cdd:COG0469 159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAV---ENLDEIIEAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 244 DVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAA 323
Cdd:COG0469 236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 324 GQYPAETVAAMARVCLGAEKIPSINVSKHRL-DVQFDNVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRISSGL 402
Cdd:COG0469 316 GKYPVEAVETMARIAEEAEKSLDYRRILDRLrDEPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKV 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278866048 403 PIFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIGSTNTTRVMTV 479
Cdd:COG0469 395 PILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
5-479 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 673.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 5 LRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 85 -KVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGM-KVFTEVTVGGPLSNNKGI 162
Cdd:cd00288 81 kDISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 163 NKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCDQDamdDVILA 242
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD---EILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 243 SDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETA 322
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 323 AGQYPAETVAAMARVCLGAEKIPSINVSKHRLDVQFD---NVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRIS 399
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPrptSTTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 400 SGLPIFAMSRHERTLNLTALYRGVTPVHFDS-----TNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTiGSTNTT 474
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTM 475
|
....*
gi 1278866048 475 RVMTV 479
Cdd:cd00288 476 RILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
6-476 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 643.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 6 RRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGK 85
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 86 VFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKL 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 166 GGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAG-CDAKIVAKVERAEAVCDqdaMDDVILASD 244
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 245 VVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAG 324
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 325 QYPAETVAAMARVCLGAEKIPS-INVSKHRL--DVQFDNVEEAIAMSAMYAANHLKgVTAIITMTESGRTALMTSRISSG 401
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAyLTNFNDRKnsDPKPSTITEAIALSAVEAAEKLD-AKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278866048 402 LPIFAMSRHERTLNLTALYRGVTPVHFDS-TNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIGSTNTTRV 476
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
5-350 |
6.43e-161 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 459.14 E-value: 6.43e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 5 LRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 85 K--VFLNIGDKFL--LDANLgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMK-VFTEVTVGGPLSNN 159
Cdd:pfam00224 81 KkdIELKAGDEMIvsTDAKY-KGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 160 KGINKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcdqDAMDDV 239
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGV---NNFDEI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 240 ILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSA 319
Cdd:pfam00224 237 LEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSG 316
|
330 340 350
....*....|....*....|....*....|..
gi 1278866048 320 ETAAGQYPAETVAAMARVCLGAEK-IPSINVS 350
Cdd:pfam00224 317 ETAKGNYPVEAVRMMHEICLEAEKaLPHRNLF 348
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
3-469 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 785.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 3 RRLRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFK 82
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 83 EGKVFLNIGDKFLLDANlGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGI 162
Cdd:PRK05826 81 EGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 163 NKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGC-DAKIVAKVERAEAVcdqDAMDDVIL 241
Cdd:PRK05826 160 NIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAV---DNIDEIIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 242 ASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAET 321
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 322 AAGQYPAETVAAMARVCLGAEKIPSINVSKHRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSG 401
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPG 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278866048 402 LPIFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIG 469
Cdd:PRK05826 397 APIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
4-479 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 724.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 4 RLRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKE 83
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 84 GKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGIN 163
Cdd:COG0469 81 GPVELKKGDTFTLTTD--DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 164 KLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcdqDAMDDVILAS 243
Cdd:COG0469 159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAV---ENLDEIIEAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 244 DVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAA 323
Cdd:COG0469 236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 324 GQYPAETVAAMARVCLGAEKIPSINVSKHRL-DVQFDNVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRISSGL 402
Cdd:COG0469 316 GKYPVEAVETMARIAEEAEKSLDYRRILDRLrDEPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKV 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278866048 403 PIFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIGSTNTTRVMTV 479
Cdd:COG0469 395 PILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
5-479 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 673.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 5 LRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 85 -KVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGM-KVFTEVTVGGPLSNNKGI 162
Cdd:cd00288 81 kDISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 163 NKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCDQDamdDVILA 242
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD---EILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 243 SDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETA 322
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 323 AGQYPAETVAAMARVCLGAEKIPSINVSKHRLDVQFD---NVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRIS 399
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPrptSTTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 400 SGLPIFAMSRHERTLNLTALYRGVTPVHFDS-----TNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTiGSTNTT 474
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTM 475
|
....*
gi 1278866048 475 RVMTV 479
Cdd:cd00288 476 RILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
6-476 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 643.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 6 RRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGK 85
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 86 VFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKL 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 166 GGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAG-CDAKIVAKVERAEAVCDqdaMDDVILASD 244
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 245 VVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAG 324
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 325 QYPAETVAAMARVCLGAEKIPS-INVSKHRL--DVQFDNVEEAIAMSAMYAANHLKgVTAIITMTESGRTALMTSRISSG 401
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAyLTNFNDRKnsDPKPSTITEAIALSAVEAAEKLD-AKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278866048 402 LPIFAMSRHERTLNLTALYRGVTPVHFDS-TNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIGSTNTTRV 476
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
5-350 |
6.43e-161 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 459.14 E-value: 6.43e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 5 LRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 85 K--VFLNIGDKFL--LDANLgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMK-VFTEVTVGGPLSNN 159
Cdd:pfam00224 81 KkdIELKAGDEMIvsTDAKY-KGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 160 KGINKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcdqDAMDDV 239
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGV---NNFDEI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 240 ILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSA 319
Cdd:pfam00224 237 LEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSG 316
|
330 340 350
....*....|....*....|....*....|..
gi 1278866048 320 ETAAGQYPAETVAAMARVCLGAEK-IPSINVS 350
Cdd:pfam00224 317 ETAKGNYPVEAVRMMHEICLEAEKaLPHRNLF 348
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
3-479 |
6.90e-146 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 425.88 E-value: 6.90e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 3 RRLRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFK 82
Cdd:PRK06247 2 KRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 83 EGKVFLNIGDKFLLDanLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGI 162
Cdd:PRK06247 82 DGKVQLANGQTFRLD--VDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 163 NKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAgcdAKIVAKVERAEAVcdqDAMDDVILA 242
Cdd:PRK06247 160 SLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAI---DRLEAIVEA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 243 SDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETA 322
Cdd:PRK06247 234 SDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 323 AGQYPAETVAAMARVCLGAEKIPSINVSKHRLDVQFD-NVEEAIAMSAMYAANHLKgVTAIITMTESGRTALMTSRISSG 401
Cdd:PRK06247 314 SGKYPVEAVRTMARIIRQVERDPTYPPLIHAQRPQPEaTKRDAISYAARDIAERLD-LAALVAYTSSGDTALRAARERPP 392
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278866048 402 LPIFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIGSTNTTRVMTV 479
Cdd:PRK06247 393 LPILALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYI 470
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-479 |
1.59e-140 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 416.25 E-value: 1.59e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 1 MSRR--LRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRV 78
Cdd:PRK06354 1 MSLRdlMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 79 STFKEGKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMK--VFTEVTVGGPL 156
Cdd:PRK06354 81 GRFEDGPIELKTGDEFILTSR--EVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVGGVL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 157 SNNKGINKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRL-ARDAGCDAKIVAKVERAEAVcdqDA 235
Cdd:PRK06354 159 SNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELiEEHNGKHIPIIAKIEKQEAI---DN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 236 MDDVILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAV 315
Cdd:PRK06354 236 IDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 316 MLSAETAAGQYPAETVAAMARVCLGAEK-IPSINVSKHRLDvQFDNVEEAIAMSAMYAANHLkGVTAIITMTESGRTALM 394
Cdd:PRK06354 316 MLSNETAAGDYPVEAVQTMATIAVRIEKdLPYRDILSKRPE-FTTTITNAISQAVSHIALQL-DAAAIVTLTKSGATARN 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 395 TSRISSGLPIFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIGSTNTT 474
Cdd:PRK06354 394 VSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLM 473
|
....*
gi 1278866048 475 RVMTV 479
Cdd:PRK06354 474 KVHVV 478
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
5-476 |
1.15e-116 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 350.89 E-value: 1.15e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 5 LRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 85 K-VFLNIGDKFLL--DANLgkgEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKG 161
Cdd:PRK09206 81 NdVSLKAGQTFTFttDKSV---VGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 162 INKLGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARR-LARDAGCDAKIVAKVERAEAVcdqDAMDDVI 240
Cdd:PRK09206 158 VNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREhLKAHGGENIQIISKIENQEGL---NNFDEIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 241 LASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAE 320
Cdd:PRK09206 235 EASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 321 TAAGQYPAETVAAMARVClgaEKIPSinVSKHRLDVQFDN----VEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTS 396
Cdd:PRK09206 315 SAKGKYPLEAVSIMATIC---ERTDR--VMNSRLESNNDNrklrITEAVCRGAVETAEKL-DAPLIVVATQGGKSARSVR 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 397 RISSGLPIFAMSRHERTLNLTALYRGVTPV---HFDSTNDGVAAAHDAVnllRDKGYLVSGDIVIVTQGDVMSTiGSTNT 473
Cdd:PRK09206 389 KYFPDATILALTTNEKTARQLVLSKGVVPQlvkEIASTDDFYRLGKELA---LQSGLAQKGDVVVMVSGALVPS-GTTNT 464
|
...
gi 1278866048 474 TRV 476
Cdd:PRK09206 465 ASV 467
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
4-480 |
5.64e-101 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 312.08 E-value: 5.64e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 4 RLRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREiAAKLGRH--VAILGDLQGPKIRVSTF 81
Cdd:PTZ00066 36 RQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVRE-AAKARPNanLGILLDTKGPEIRTGFL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 82 KEGK-VFLNIGD--KFLLDANLgkgEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSN 158
Cdd:PTZ00066 115 KNHKpITLKEGQtlKITTDYTF---LGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 159 NKGINKLGGGLSAEALTDKDKADIVTAAL-IGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCDqdaMD 237
Cdd:PTZ00066 192 RKNMNLPGVKVELPVIGEKDKNDILNFAIpMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLIN---FD 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 238 DVILASDVVMVARGDLGVEIgDPELVGI-QKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVM 316
Cdd:PTZ00066 269 EILAESDGIMVARGDLGMEI-PPEKVFLaQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVM 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 317 LSAETAAGQYPAETVAAMARVCLGAEKIPSINVSKHRLDVQFD---NVEEAIAMSAMYAANHLkGVTAIITMTESGRTAL 393
Cdd:PTZ00066 348 LSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPtpvSVQEAVARSAVETAEDI-NAKLIIALTETGNTAR 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 394 MTSRISSGLPIFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQGDVMSTIGSTNT 473
Cdd:PTZ00066 427 LISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNL 506
|
....*..
gi 1278866048 474 TRVMTVE 480
Cdd:PTZ00066 507 MKVVKIP 513
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-480 |
1.45e-95 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 298.05 E-value: 1.45e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 2 SRRLRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTF 81
Cdd:PLN02461 17 GLRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 82 KEGK-VFLNIGDKFLL--DANLgkgEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLE--VQGMKVFTEVTVGGPL 156
Cdd:PLN02461 97 KDGKpVQLKQGQEITIttDYSI---KGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAML 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 157 SNNKGINKLGGGLSAEALTDKDKADIVTAALI-GVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCDqda 235
Cdd:PLN02461 174 GERKNVNLPGVVVDLPTLTEKDKEDILQWGVPnKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDN--- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 236 MDDVILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAV 315
Cdd:PLN02461 251 FDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 316 MLSAETAAGQYPAETVAAMARVCLGAEK-IPSINVSKHRLDVQFD--NVEEAIAMSAMYAANHLKGvTAIITMTESGRTA 392
Cdd:PLN02461 331 MLSGETAAGAYPELAVKTMARICREAEAsLDYGALFKEIMRSAPLpmSPLESLASSAVRTANKVKA-SLIVVLTRGGTTA 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 393 LMTSRISSGLPIFAMSRHERTLNLTA-------------LYRGVTPV---------HFDSTNDGVAAahdAVNLLRDKGY 450
Cdd:PLN02461 410 RLVAKYRPAVPILSVVVPEITTDSFDwscsdeaparhslIYRGLIPVlaegsakatDSESTEEILEA---AIEHAKKKGL 486
|
490 500 510
....*....|....*....|....*....|
gi 1278866048 451 LVSGDIVIvtqgdVMSTIGSTNTTRVMTVE 480
Cdd:PLN02461 487 CKPGDSVV-----ALHRIGGASVIKILTVK 511
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
33-480 |
5.17e-90 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 281.94 E-value: 5.17e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 33 NVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLG-KGEGDKEKVG 111
Cdd:PTZ00300 2 SVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAfADKGTKDKFY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 112 IDYKGLPADVVPGDILLLDDGRVQLKVL---EVQGMKVFteVTVGGPLSNNKGINKLGGGLSAEALTDKDKADIVTAALI 188
Cdd:PTZ00300 82 IDYQNLSKVVRPGGYIYIDDGILILHVQsheDEQTLKCT--VTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 189 GVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCDqdaMDDVILASDVVMVARGDLGVEIGDPELVGIQKA 268
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQN---IDSIIEESDGIMVARGDLGVEIPAEKVVVAQKI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 269 LIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVAAMARVCLGAEKIPSIN 348
Cdd:PTZ00300 237 LISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 349 V---SKHRLDVQFDNVEEAIAMSAMYAANHLKGvTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTP 425
Cdd:PTZ00300 317 VffnSIKKLQPIPMSAEEAVCSSAVNSVYETKA-KALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVES 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1278866048 426 VHFDSTNDGvaaaHD---------AVNLLRDKGYLVSGDIVIVTQGDvMSTIGSTNTTRVMTVE 480
Cdd:PTZ00300 396 VFFDAERLG----HDegkeqrvamGVGFAKSKGYVQSGDLMVVVHAD-HKVKGYANQTRIILVS 454
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
6-461 |
1.53e-83 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 268.72 E-value: 1.53e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 6 RRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHV-AILGDLQGPKIRVSTFKEg 84
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 85 KVFLNIGDKFLLdaNLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINK 164
Cdd:PLN02623 189 PIMLEEGQEFTF--TIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 165 LGGGLSAEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCDqdaMDDVILASD 244
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPN---LHSIITASD 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 245 VVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAG 324
Cdd:PLN02623 344 GAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHG 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 325 QYPAETVAAMARVCLGAEKIPSINVSKHRLDVQFDN-VEEAIAMSAMYAANHLKgvTAIITMTESGRTALMTSRISSGLP 403
Cdd:PLN02623 424 KFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNhMSEMFAFHATMMANTLG--TSIIVFTRTGFMAILLSHYRPSGT 501
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1278866048 404 IFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSGDIVIVTQ 461
Cdd:PLN02623 502 IFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALVQ 559
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
11-344 |
1.15e-81 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 256.80 E-value: 1.15e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 11 VTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREiaakLGRHVAILGDLQGPKIRVSTFKEGKVFLNI 90
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKS----LDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 91 GDKFLLDANlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLS 170
Cdd:PRK06739 82 GDSFILHTQ--PVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 171 AEALTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDA-KIVAKVERAEAVcdqDAMDDVILASDVVMVA 249
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAI---ENFQDICKEADGIMIA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 250 RGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAE 329
Cdd:PRK06739 237 RGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIE 316
|
330
....*....|....*
gi 1278866048 330 TVAAMARVCLGAEKI 344
Cdd:PRK06739 317 SVSTLRLVSEFAEHV 331
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
3-480 |
2.13e-77 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 250.82 E-value: 2.13e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 3 RRLRRTKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTF- 81
Cdd:PLN02762 22 RSTRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLg 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 82 -------KEGKVFLNIGDKFlldanlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGG 154
Cdd:PLN02762 102 gassakaEDGEEWTFTVRKF-------DGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 155 PL---------SNNKGINKLGGGLSAeaLTDKDKADIVTAALIGVDYLAVSFPRCGEDLNYARRL--ARDAGCDAKIVAK 223
Cdd:PLN02762 175 LLlpranltfwRDGSLVRERNAMLPT--ISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYiaARSRDSDIGVIAK 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 224 VERAEAVcdqDAMDDVILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMD 303
Cdd:PLN02762 253 IESLDSL---KNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVAD 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 304 VANAVLDGTDAVMLSAETAAGQYPAETVAAMARVCL-----GAEKIPSINVSKHRLDVQF-DNVEEAIAMSAMYAANHLk 377
Cdd:PLN02762 330 VSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLrmelwSREEKRHEALELPQLSSSLsDRISEEICNSAAKMANNL- 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 378 GVTAIITMTESGRTALMTSRISSGLPIFAMSRH---ERTLNltaLYRGVTPVHFDSTNDGVAAAHDAVNLLRDKGYLVSG 454
Cdd:PLN02762 409 GVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTtsvRRRLN---LQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSG 485
|
490 500
....*....|....*....|....*.
gi 1278866048 455 DIVIVTQgDVmSTIGSTNTTRVMTVE 480
Cdd:PLN02762 486 DLVIAVS-DL-TPSSMLQSIQVRNVP 509
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
8-480 |
3.76e-61 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 208.37 E-value: 3.76e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 8 TKIVTTLGPATDRDNNLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVF 87
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 88 LNIGDKFLLDANLGKgEGDKEKVGIDYKGLPADVVPGDILLL--------DDGRVQLKVLEVQGMKVFTEV----TVGGP 155
Cdd:PLN02765 110 LKAGNTVTLTPDQSK-EASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVknsaTLAGS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 156 L----SNNKGInklggglSAEALTDKDKADIVT-AALIGVDYLAVSFPRCGEDLNYARRLARDAGC-DAKIVAKVERAEA 229
Cdd:PLN02765 189 LftlhVSQVRI-------DLPTLSEKDKEVISTwGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLsQTQIFAKIENVEG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 230 VcdqDAMDDVILASDVVMVARGDLGVEIgDPELVGI-QKALIRRARQLNRAVITaTQMMESMITNPMPTRAEVMDVANAV 308
Cdd:PLN02765 262 L---THFDEILQEADGIILSRGNLGIDL-PPEKVFLfQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAV 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 309 LDGTDAVMLSAETAAGQYPAETVAAMARVCLGAEKipsinVSKHrlDVQFDNV----------EEAIAMSAMYAANHLKG 378
Cdd:PLN02765 337 LDGADAILLGAETLRGLYPVETISTVGRICAEAEK-----VFNQ--DLYFKKTvkyvgepmshLESIASSAVRAAIKVKA 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 379 vTAIITMTESGRTALMTSRISSGLPIFAM---------SRHERTLNLTA----LYRGVTPVHFDSTN--DGVAAAHD--- 440
Cdd:PLN02765 410 -SVIIVFTSSGRAARLIAKYRPTMPVLSVviprlktnqLKWSFTGAFQArqclIVRGLFPMLADPRHsaESTSATNEsvl 488
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1278866048 441 --AVNLLRDKGYLVSGDIVIVTQgdvmsTIGSTNTTRVMTVE 480
Cdd:PLN02765 489 kvALDHGKAAGVIKSHDRVVVCQ-----KVGDSSVVKIIELD 525
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
363-477 |
2.15e-38 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 135.69 E-value: 2.15e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 363 EAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVHFDSTNDGVAAAHDAV 442
Cdd:pfam02887 1 EAIAHAAVEAAEEL-GAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAV 79
|
90 100 110
....*....|....*....|....*....|....*
gi 1278866048 443 NLLRDKGYLVSGDIVIVTQGDVMSTIGSTNTTRVM 477
Cdd:pfam02887 80 KVAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
3-337 |
1.92e-34 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 134.76 E-value: 1.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 3 RRLRRTKIVTTLGP--ATDRDNNLEkIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVST 80
Cdd:PRK08187 130 PAARRTRIMVTLPSeaADDPDFVLR-LAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGA 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 81 F--KEGKVFLNIGDKFLLDANLGKGEGDKE--KVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGP- 155
Cdd:PRK08187 209 VagPLGKTRLYTGDRLALVAQGPPRRIDEEhfQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPk 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 156 ---LSNNKGINKLGGGLSAEALTDKDKAD---IVTAAligvDYLAVSFPRCGEDLN-----YARRLARDAGcDAKIVAKV 224
Cdd:PRK08187 289 glkLKPEKGLNFPDTALDLPALTEKDRADldfVARHA----DLVGYSFVQSPGDVEalqaaLAARRPDDWR-KLGLVLKI 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 225 ERAEAVcdqDAMDDVILASD-----VVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRA 299
Cdd:PRK08187 364 ETPRAV---ANLPELIVQAAgrqpfGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRA 440
|
330 340 350
....*....|....*....|....*....|....*...
gi 1278866048 300 EVMDVANAvlDGTDAVMLSaetaAGQYPAETVAAMARV 337
Cdd:PRK08187 441 EMTDAAMA--ARAECVMLN----KGPYLVEAVTFLDDL 472
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
6-317 |
4.07e-23 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 102.72 E-value: 4.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 6 RRTKIVTTLgP---ATDRDNnLEKIIAAGANVVRMNFSHGTPEDHKLRADKVREIAAKLGRHVAILGDLQGPKIRVST-- 80
Cdd:PRK14725 139 RPTRIMVTL-PteaADDPDL-VRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPia 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 --------------------------------------------------------------------------------
Cdd:PRK14725 217 pgprviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrkltvtevddeg 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 81 -------------------------------FKEGKVFLNIGDKFLL--DANLG---KGEGDKEKVGIdykGLPA---DV 121
Cdd:PRK14725 297 vlaegsqtaylangtllrlgrhdstrvgglpPVEQKLRLKVGDRLVLtrDDAPGdpaQGDAPPARISC---TLPEafrAA 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 122 VPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGP----LSNNKGINKLGGGLSAEALTDKDKADIVTAALIGvDYLAVSF 197
Cdd:PRK14725 374 RVGERVWFDDGKIGAVVVKVEADEVELRITHARPggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSF 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278866048 198 PRCGEDLNY-----ARRLARDAGcdakIVAKVERAEAVcdqDAMDDVILAS----DV-VMVARGDLGVEIGDPELVGIQK 267
Cdd:PRK14725 453 VRSPEDVRLlldalEKLGADDLG----VVLKIETRRAF---ENLPRILLEAmrhpRFgVMIARGDLAVEVGFERLAEVQE 525
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1278866048 268 ALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLdgTDAVML 317
Cdd:PRK14725 526 EILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVML 573
|
|
| |
