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Conserved domains on  [gi|1278878664|gb|PJD66054|]
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methyl-accepting chemotaxis protein II [Enterobacter kobei]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11487583)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 1-555 0e+00

methyl-accepting chemotaxis protein II; Provisional


:

Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 951.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664   1 MLNRIRVVTMLMMVLVIFALLQLISGGLFFSSLKQNQDSFAASNDLRLQQSELTSTWDLMLQTRINLSRSSARMMMDPNN 80
Cdd:PRK15048    1 MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  81 QQSSAKTDLLKNARATLADAAKHYAAFKQIAPQPAMAQVSQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNA 160
Cdd:PRK15048   81 QQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 161 LGAALGEYAKASGDLYHSAFTESQNDYRFAKWQMAAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLA 240
Cdd:PRK15048  161 MGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 241 VSGRNEITELANSVDHMQRSLIDTVANVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADN 320
Cdd:PRK15048  241 IDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 321 ARQASQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE 400
Cdd:PRK15048  321 ARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 401 VRNLASRSANAAKEIKALIEDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDR 480
Cdd:PRK15048  401 VRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDR 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278878664 481 VTQQNAALVQESAAAAAALEDQASRLKMAVSAFRLASLAGNTVTAQAtyKAPAAESTATRLRAAPAGQDENWETF 555
Cdd:PRK15048  481 VTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLTNKPQTP--SRPASEQPPAQPRLRIAEQDPNWETF 553
 
Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 1-555 0e+00

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 951.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664   1 MLNRIRVVTMLMMVLVIFALLQLISGGLFFSSLKQNQDSFAASNDLRLQQSELTSTWDLMLQTRINLSRSSARMMMDPNN 80
Cdd:PRK15048    1 MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  81 QQSSAKTDLLKNARATLADAAKHYAAFKQIAPQPAMAQVSQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNA 160
Cdd:PRK15048   81 QQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 161 LGAALGEYAKASGDLYHSAFTESQNDYRFAKWQMAAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLA 240
Cdd:PRK15048  161 MGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 241 VSGRNEITELANSVDHMQRSLIDTVANVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADN 320
Cdd:PRK15048  241 IDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 321 ARQASQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE 400
Cdd:PRK15048  321 ARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 401 VRNLASRSANAAKEIKALIEDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDR 480
Cdd:PRK15048  401 VRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDR 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278878664 481 VTQQNAALVQESAAAAAALEDQASRLKMAVSAFRLASLAGNTVTAQAtyKAPAAESTATRLRAAPAGQDENWETF 555
Cdd:PRK15048  481 VTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLTNKPQTP--SRPASEQPPAQPRLRIAEQDPNWETF 553
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
13-515 7.08e-94

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 296.93  E-value: 7.08e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  13 MVLVIFALLQLISGGLFFSSLKQNQDSFAASNDLRLQQSELTSTWDLMLQTRINLSRSSARMMMDPNNQQSSAKTDLLKN 92
Cdd:COG0840     1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  93 ARATLADAAKHYAAFKQIAPQ--PAMAQVSQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNALGAALGEYAK 170
Cdd:COG0840    81 LLALLLALLLLLLALLALALAalALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 171 ASGDLYHSAFTESQNDYRFAKWQMAAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLAVSGRNEITEL 250
Cdd:COG0840   161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 251 ANSVDHMQRSLIDTVANVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAES 330
Cdd:COG0840   241 ADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 331 ASETAQRGGRVVDGVV--------------KTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAV 396
Cdd:COG0840   321 ASELAEEGGEVVEEAVegieeiresveetaETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAV 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 397 VAGEVRNLASRSANAAKEIKALIEDSVSRVDTGSVLVES--------------AGETMNDIVNAVTRVTDIMGEIASASD 462
Cdd:COG0840   401 VADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEgseeveegvelveeAGEALEEIVEAVEEVSDLIQEIAAASE 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1278878664 463 EQSRGIDQVALAVSEMDRVTQQNAALVQESAAAAAALEDQASRLKMAVSAFRL 515
Cdd:COG0840   481 EQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 267-514 6.68e-71

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 227.94  E-value: 6.68e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  267 NVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAESASETAQRGGRVVDGVV 346
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  347 KTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSANAAKEIKALI------- 419
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  420 -------EDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNAALVQES 492
Cdd:smart00283 161 neavaamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 1278878664  493 AAAAAALEDQASRLKMAVSAFR 514
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 325-482 1.82e-63

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 205.36  E-value: 1.82e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 325 SQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNL 404
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 405 ASRSANAAKEIKALI--------------EDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQ 470
Cdd:pfam00015  81 AERSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQ 160

                         170
                  ....*....|..
gi 1278878664 471 VALAVSEMDRVT 482
Cdd:pfam00015 161 VNQAVARMDQVT 172
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 294-492 5.68e-63

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 205.16  E-value: 5.68e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 294 EQQASALEETAASMEQLTATVKQNADNARQASQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQT 373
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 374 NILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSANAAKEIKALIEDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDI 453
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1278878664 454 MGEIASASDEQSRGIDQVALAVSEMDRVTQQNAALVQES 492
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEI 199
 
Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 1-555 0e+00

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 951.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664   1 MLNRIRVVTMLMMVLVIFALLQLISGGLFFSSLKQNQDSFAASNDLRLQQSELTSTWDLMLQTRINLSRSSARMMMDPNN 80
Cdd:PRK15048    1 MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  81 QQSSAKTDLLKNARATLADAAKHYAAFKQIAPQPAMAQVSQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNA 160
Cdd:PRK15048   81 QQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 161 LGAALGEYAKASGDLYHSAFTESQNDYRFAKWQMAAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLA 240
Cdd:PRK15048  161 MGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 241 VSGRNEITELANSVDHMQRSLIDTVANVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADN 320
Cdd:PRK15048  241 IDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 321 ARQASQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE 400
Cdd:PRK15048  321 ARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 401 VRNLASRSANAAKEIKALIEDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDR 480
Cdd:PRK15048  401 VRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDR 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278878664 481 VTQQNAALVQESAAAAAALEDQASRLKMAVSAFRLASLAGNTVTAQAtyKAPAAESTATRLRAAPAGQDENWETF 555
Cdd:PRK15048  481 VTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLTNKPQTP--SRPASEQPPAQPRLRIAEQDPNWETF 553
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-555 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 628.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664   1 MLNRIRVVTMLMMVLVIFALLQLISGGLFFSSLKQNQDSFAASNDLRLQQSELTSTWDLMLQTRINLSRSSARMMMDPNN 80
Cdd:PRK15041    1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  81 QQSSAK-TDLLKNARATLADAAKHYAAFKQIAPQPAMAQV-SQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQ 158
Cdd:PRK15041   81 IGSGSTvAELMQSASISLKQAEKNWADYEALPRDPRQSTAaAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 159 NALGAALGEYAKASGDLYHSAFTESQNDYRFAKWQMAAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKT 238
Cdd:PRK15041  161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 239 LAVSGRNEITELANSVDHMQRSLIDTVANVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNA 318
Cdd:PRK15041  241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 319 DNARQASQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 398
Cdd:PRK15041  321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 399 GEVRNLASRSANAAKEIKALIEDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEM 478
Cdd:PRK15041  401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278878664 479 DRVTQQNAALVQESAAAAAALEDQASRLKMAVSAFRLASLAGNTVTAQATYKAPAAESTAtrlRAAPAGQDENWETF 555
Cdd:PRK15041  481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQQQQQQRETSAVVKTVTPATPR---KMAVADSGENWETF 554
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
1-515 3.08e-145

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 429.11  E-value: 3.08e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664   1 MLNRIRVVTMLMMVLVIFALLQLISGGLFFSSLK---QNQDSFAASNDlrlQQSELTSTWDLMLQ--TRINLSRSSARMM 75
Cdd:PRK09793    1 MFNRIRISTTLFLILILCGILQIGSNGMSFWAFRddlQRLNQVEQSNQ---QRAALAQTRAVMLQasTALNKAGTLTALS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  76 MDPNNQQSsaktdLLKNARATLADAAKHYAAF-KQIAPQPAMAQVSQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPT 154
Cdd:PRK09793   78 YPADDIKT-----LMTTARASLTQSTTLFKSFmAMTAGNEHVRALQKETEKSFARWHNDLEHQATWLESNQLSDFLTAPV 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 155 QGMQNALGAALGEYAKASGDLYHSAFTESQNDYrfakwQMAAMALALVIVLVAVWYG-----IRHILLNPLGRVIAHIRE 229
Cdd:PRK09793  153 QGSQNAFDVNFEAWQLEINHVLEAASAQSQRNY-----QISALVFISMIIVAAIYISsalwwTRKMIVQPLAIIGSHFDS 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 230 IAGGDLTKTLAVSGRNEITELANSVDHMQRSLIDTVANVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQ 309
Cdd:PRK09793  228 IAAGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQ 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 310 LTATVKQNADNARQASQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGE 389
Cdd:PRK09793  308 LTATVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGE 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 390 QGRGFAVVAGEVRNLASRSANAAKEIKALIEDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGID 469
Cdd:PRK09793  388 QGRGFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIE 467

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1278878664 470 QVALAVSEMDRVTQQNAALVQESAAAAAALEDQASRLKMAVSAFRL 515
Cdd:PRK09793  468 QVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTL 513
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
13-515 7.08e-94

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 296.93  E-value: 7.08e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  13 MVLVIFALLQLISGGLFFSSLKQNQDSFAASNDLRLQQSELTSTWDLMLQTRINLSRSSARMMMDPNNQQSSAKTDLLKN 92
Cdd:COG0840     1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  93 ARATLADAAKHYAAFKQIAPQ--PAMAQVSQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNALGAALGEYAK 170
Cdd:COG0840    81 LLALLLALLLLLLALLALALAalALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 171 ASGDLYHSAFTESQNDYRFAKWQMAAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLAVSGRNEITEL 250
Cdd:COG0840   161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 251 ANSVDHMQRSLIDTVANVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAES 330
Cdd:COG0840   241 ADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 331 ASETAQRGGRVVDGVV--------------KTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAV 396
Cdd:COG0840   321 ASELAEEGGEVVEEAVegieeiresveetaETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAV 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 397 VAGEVRNLASRSANAAKEIKALIEDSVSRVDTGSVLVES--------------AGETMNDIVNAVTRVTDIMGEIASASD 462
Cdd:COG0840   401 VADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEgseeveegvelveeAGEALEEIVEAVEEVSDLIQEIAAASE 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1278878664 463 EQSRGIDQVALAVSEMDRVTQQNAALVQESAAAAAALEDQASRLKMAVSAFRL 515
Cdd:COG0840   481 EQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 267-514 6.68e-71

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 227.94  E-value: 6.68e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  267 NVRSGTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAESASETAQRGGRVVDGVV 346
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  347 KTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSANAAKEIKALI------- 419
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  420 -------EDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNAALVQES 492
Cdd:smart00283 161 neavaamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 1278878664  493 AAAAAALEDQASRLKMAVSAFR 514
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 325-482 1.82e-63

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 205.36  E-value: 1.82e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 325 SQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNL 404
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 405 ASRSANAAKEIKALI--------------EDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQ 470
Cdd:pfam00015  81 AERSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQ 160

                         170
                  ....*....|..
gi 1278878664 471 VALAVSEMDRVT 482
Cdd:pfam00015 161 VNQAVARMDQVT 172
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 294-492 5.68e-63

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 205.16  E-value: 5.68e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 294 EQQASALEETAASMEQLTATVKQNADNARQASQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQT 373
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 374 NILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSANAAKEIKALIEDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDI 453
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1278878664 454 MGEIASASDEQSRGIDQVALAVSEMDRVTQQNAALVQES 492
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEI 199
Tar_Tsr_sensor cd19407
ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar ...
 44-168 1.19e-34

ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar (taxis to aspartate and repellents) and Tsr (taxis to serine and repellents) are homologous transmembrane chemoreceptors that have a high specificity for aspartate and serine, respectively. Both are homodimeric receptors and contain an N-terminal periplasmic ligand binding domain, a transmembrane region, a HAMP domain and a C-terminal cytosolic signaling domain. E. coli Tar mediates bacterial chemotaxis toward attractants, including aspartate (Asp) and maltose, and away from repellents such as nickel and cobalt ions. Tsr has many roles, including sensing of external (serine, leucine) and internal (pH) environments. In Salmonella enterica serovar Typhimurium, Tsr, also called methyl-accepting chemotaxis protein (MCP), is involved in sensing host-derived nitrate in murine intestinal epithelium, thus contributing to invasion of Peyer's patches. This model represents the ligand binding domain of Tar and Tsr.


Pssm-ID: 438625 [Multi-domain]  Cd Length: 131  Bit Score: 127.05  E-value: 1.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  44 NDLRLQQSELTSTWDLMLQTRINLSRSSARMMMDPNNQQSSAKTDLLKNARATLADAAKHYAAFKQIAPQP-AMAQVSQN 122
Cdd:cd19407     1 QQLRQQQSALNDSWVALLQARNTLNRAAIRYLLDANNGGGAAVAELLDQAKKSLAQAEKHFAQFKALPKLPgQDEALAAE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1278878664 123 IDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNALGAALGEY 168
Cdd:cd19407    81 LEQSYQAYHDALAELIQFLEAGNIDAFLDQPTQGYQDAFEKAYNAY 126
TarH pfam02203
Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a ...
 26-170 6.18e-28

Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors, such as E.coli Tar (taxis to aspartate and repellents), which is a receptor for the attractant L-aspartate and also recognizes proteogenic amino acids, phthalic acid, Malic acid, 3,4-dihydroxymandelic acid, citrate, benzoate and derivatives, protocatechuate, vanillate, quinate, shikimate and dehydroshikimate (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426656 [Multi-domain]  Cd Length: 152  Bit Score: 109.31  E-value: 6.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  26 GGLFFSSLKQNQDSFAASNDLRLQQ-SELTSTWDLMLQTRINLSRSSARMMMDPNNQQssakTDLLKNARATLADAAKHY 104
Cdd:pfam02203   1 GGLGLSGLSRSNDALREVYTNRLQQqAALADAWLLLLQARLTLNRAGIAALLPDAPDA----AELLARARESLAQSDAAW 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278878664 105 AAFKQIAPQPAM-AQVSQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNALGAALGEYAK 170
Cdd:pfam02203  77 KAYLALPRTPDEeEALAAELKAKYDALQDGLAPLIAALRAGDLDAFFDQPTQKIQPLFEALYNAYLA 143
TarH smart00319
Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the ...
 46-180 4.91e-27

Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the wild-type bacterial aspartate receptor, Tar.


Pssm-ID: 128614 [Multi-domain]  Cd Length: 135  Bit Score: 106.01  E-value: 4.91e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664   46 LRLQQSELTSTWDLMLQTRINLSRSSARMMMdpNNQQSSAKTdLLKNARATLADAAKHYAAFKQIAPQP-AMAQVSQNID 124
Cdd:smart00319   3 SSYQQAALSLSRVLLLQARNNLNRAGIRMMQ--NNIGSKAKK-LMTAASESLKQAEKNYKSYENMTALPrADRALDAELK 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1278878664  125 EKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNALGAALGEYAKASGDLYHSAF 180
Cdd:smart00319  80 EKFQQYITALQELIQILGNGNLGAFFDQPTQGMQDGFDPAYRDWLQQAVALKGQAV 135
chemoreceptor_sensor cd00181
4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand ...
 44-172 4.21e-13

4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand binding sensor domain of chemoreceptors and related sensor histidine kinases forms homodimers and binds to ligands via the dimerization interface, a feature that appears to be conserved in this domain superfamily. This family includes ligand binding sensor domain of several chemoreceptors, such as Escherichia coli Tar, Tsr, NarQ, NarX, Pseudomonas aeruginosa KinB, Rhodopseudomonas palustris histidine kinase HK9 chemoreceptors, Comamonas testosteroni CNB-2 MCP2201 and Anaeromyxobacter dehalogenans histidine kinase Adeh_2942, among others.


Pssm-ID: 438624 [Multi-domain]  Cd Length: 119  Bit Score: 66.00  E-value: 4.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  44 NDLRLQQSELTSTWDLMLQTRINLSRSSARMmmdpnnqqssaKTDLLKNARATLADAAKHYAAFKQIAPQPAMAqvSQNI 123
Cdd:cd00181     1 QEIRQQASAISSLESLVLQARVTLRAEALTG-----------VEELGDALIRALKQTAAVLAQFRALTRDPPEA--EAEI 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1278878664 124 DEKYTAYFAGLTELIQFL-ESGNMDAYFAQP-TQGMQNALGAALGEYAKAS 172
Cdd:cd00181    68 LDKVQDYQKALAALIPALlERGAESALFDQSeAQGGLELLLSLLQQLTAAG 118
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
214-266 6.17e-09

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 51.87  E-value: 6.17e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1278878664  214 HILLNPLGRVIAHIREIAGGDLTKTLAVSGRNEITELANSVDHMQRSLIDTVA 266
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
212-263 1.56e-08

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 50.70  E-value: 1.56e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1278878664 212 IRHILLNPLGRVIAHIREIAGGDLTKTLAVSGRNEITELANSVDHMQRSLID 263
Cdd:pfam00672   2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 217-261 1.15e-07

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 48.21  E-value: 1.15e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1278878664 217 LNPLGRVIAHIREIAGGDLTKTLAVSGRNEITELANSVDHMQRSL 261
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 198-261 3.41e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 49.58  E-value: 3.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278878664 198 ALALVIVLVAVWYGIR--HILLNPLGRVIAHIREIAGGDLTKTLAVSGRNEITELANSVDHMQRSL 261
Cdd:COG5000    13 LIALLLLLLALWLALLlaRRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQL 78
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
1-551 1.31e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 48.19  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664   1 MLNRIRVVTMLMMVLVIFALLQLISGGLFFSSLKQNQDSFAASNDLRLQQSELTSTWDLMLQTRINLSRSSARMMMDPNN 80
Cdd:COG2770    21 LAGALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664  81 QQSSAKTDLLKNARATLADAAKHYAAFKQIAPQPAMAQVSQNIDEKYTAYFAGLTELIQFLESGNMDAYFAQPTQGMQNA 160
Cdd:COG2770   101 ALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 161 LGAALGEYAKASGDLYHSAFTESQNDYRFAKWQMAAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLA 240
Cdd:COG2770   181 AAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIP 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 241 VSGRNEITELANSVDHMQRSLIDTVANVRSGTDAIytgtSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADN 320
Cdd:COG2770   261 VSRKDEIGELARAFNRMADSLRESIEEAEEEEELA----EAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLL 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 321 ARQASQLAESASETAQRGGRVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGE 400
Cdd:COG2770   337 LLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLAL 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 401 VRNLASRSANAAKEIKALIEDSVSRVDTGSVLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDR 480
Cdd:COG2770   417 LALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEE 496

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1278878664 481 VTQQNAALVQESAAAAAALEDQASRLKMAVSAFRLASLAGNTVTAQATYKAPAAESTATRLRAAPAGQDEN 551
Cdd:COG2770   497 EAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEAAALL 567
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 195-262 1.11e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 41.98  E-value: 1.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278878664 195 AAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLAVSGRNEITELANSVDHMQRSLI 262
Cdd:COG4192   330 AIALLSLLLAVLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRVFRDQAI 397
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 191-516 1.23e-03

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 41.41  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 191 KWQMAAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLAVSGRNEITELANSVDHMQRSLIDTVANVRS 270
Cdd:COG3850   117 RKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEE 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 271 GTDAIYTGTSEIAMGNNDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAESASETAQRGGRVVDGVVKTMH 350
Cdd:COG3850   197 EEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLAS 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 351 EIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSANAAKEIKALIEDSVSRVDTGS 430
Cdd:COG3850   277 ALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAA 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278878664 431 VLVESAGETMNDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNAALVQESAAAAAALEDQASRLKMAV 510
Cdd:COG3850   357 AAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLIVSIIAGGEAIARGEAL 436


                  ....*.
gi 1278878664 511 SAFRLA 516
Cdd:COG3850   437 AARGLA 442
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
195-261 4.91e-03

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 39.65  E-value: 4.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278878664 195 AAMALALVIVLVAVWYGIRHILLNPLGRVIAHIREIAGGDLTKTLAVSGRNEITELANSVDHMQRSL 261
Cdd:PRK10600  128 RVFAVFMALLLVFTIIWLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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