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Conserved domains on  [gi|1305003196|gb|PKG68510|]
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magnesium and cobalt transport protein CorA [Pseudoalteromonas arctica]

Protein Classification

magnesium and cobalt transport protein CorA( domain architecture ID 10191293)

magnesium and cobalt transport protein CorA mediates both influx and efflux of magnesium, and may also transport nickel and cobalt

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 77-372 6.34e-156

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 439.94  E-value: 6.34e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  77 TVRWIHVSN-TDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLkleTHEPNNTILDIEQVSLLLYDN 155
Cdd:cd12828     1 GVTWINVDGlHDIELIEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKML---YYDEDTGELESEQVSLILGKN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 156 VLLSFQEKPGDVWQSVRGRLHTENRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSI 235
Cdd:cd12828    78 YVISFQERPGDVFDPVRERLRNGKGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLENPTPETLERIHKL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 236 KRELALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVL 315
Cdd:cd12828   158 KRELLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMKVL 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305003196 316 TIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12828   238 TIISTIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
 
Name Accession Description Interval E-value
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 77-372 6.34e-156

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 439.94  E-value: 6.34e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  77 TVRWIHVSN-TDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLkleTHEPNNTILDIEQVSLLLYDN 155
Cdd:cd12828     1 GVTWINVDGlHDIELIEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKML---YYDEDTGELESEQVSLILGKN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 156 VLLSFQEKPGDVWQSVRGRLHTENRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSI 235
Cdd:cd12828    78 YVISFQERPGDVFDPVRERLRNGKGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLENPTPETLERIHKL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 236 KRELALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVL 315
Cdd:cd12828   158 KRELLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMKVL 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305003196 316 TIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12828   238 TIISTIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
59-372 7.92e-120

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 348.74  E-value: 7.92e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  59 KEVSDIDEFLKTPqpewaTVRWIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLkleTHEP 138
Cdd:COG0598     1 RELDALEELLDPE-----GFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTL---NYNE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 139 NNTILDIEQVSLLLYDNVLLSFQEKPGDVWQSVRGRLHtENRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEV 218
Cdd:COG0598    73 EEEELETGPLSIFLGPNFLITVRERPLDAFDDVRERLE-RGPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELED 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 219 TTLENPTPHVLHHIHSIKRELALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSE 298
Cdd:COG0598   152 ELFESPDNELLRRLYRLRRELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLD 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1305003196 299 LYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:COG0598   232 AYLSLISNRQNEIMKVLTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 56-372 1.62e-95

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 287.75  E-value: 1.62e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  56 IEAKEVSDIDEFLKTPQPEwATVRWIHVSN-TDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLE 134
Cdd:TIGR00383   6 IEKSRLIKIPFFEEFSQEL-NTVLWIDLIEpTDEERLAKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFFLNED 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 135 ThepnNTILDIEQVSLLLYDNVLLSFQEKPGDVWQSVRGRLHTeNRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILE 214
Cdd:TIGR00383  85 E----DDTFETEQVSFILGKNLLFTIHERELPAFDSIRERIRT-SQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 215 ELEVTTLENPTPHVLHHIHSIKRELALLRRIVWPMREVIDHLYREEG-GRIDDSTRPYLRDVYEHNIQIVEIIESYREMV 293
Cdd:TIGR00383 160 ELEDEIISGPTSTLMDEILSLRTELLALRRSLWPLRDVLNFLLRKTHlPIQTEEVREYLRDIYDHILSLLEMIETYRELL 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1305003196 294 SGLSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:TIGR00383 240 SSLMDLYLSLVNNKMNEIMKILTVVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 75-369 3.43e-74

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 232.21  E-value: 3.43e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  75 WATVRWIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLEthePNNTILDIEQVSLLLYD 154
Cdd:pfam01544   1 EQGFVWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLD---DSEEADELVTVSILLGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 155 NVLLSFQEKPGDVWQSVRGRLhtENRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHS 234
Cdd:pfam01544  78 NFLITVRHEPLPALDEVRKRL--TLLGGGPLDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDETNNELLRELAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 235 IKRELALLRRIVWPMREVIDHLYR-EEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMK 313
Cdd:pfam01544 156 LRRSLVYLRRSLLPQRDVLNRLLRrEDDPLLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMK 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305003196 314 VLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYP-VLWCVFILITAAMIFIFWRK 369
Cdd:pfam01544 236 VLTVVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPfVLILGLMILLAILLLFYFRR 292
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
266-372 1.78e-16

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 79.38  E-value: 1.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 266 DSTRPYLRDVYE---HNiqiveiiESYREMVSGLSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPEL 342
Cdd:PRK11085  214 EQAREILRDIESllpHN-------ESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPEL 286

                          90       100       110
                  ....*....|....*....|....*....|
gi 1305003196 343 NWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:PRK11085  287 KWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
 
Name Accession Description Interval E-value
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 77-372 6.34e-156

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 439.94  E-value: 6.34e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  77 TVRWIHVSN-TDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLkleTHEPNNTILDIEQVSLLLYDN 155
Cdd:cd12828     1 GVTWINVDGlHDIELIEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKML---YYDEDTGELESEQVSLILGKN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 156 VLLSFQEKPGDVWQSVRGRLHTENRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSI 235
Cdd:cd12828    78 YVISFQERPGDVFDPVRERLRNGKGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLENPTPETLERIHKL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 236 KRELALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVL 315
Cdd:cd12828   158 KRELLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMKVL 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305003196 316 TIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12828   238 TIISTIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
59-372 7.92e-120

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 348.74  E-value: 7.92e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  59 KEVSDIDEFLKTPqpewaTVRWIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLkleTHEP 138
Cdd:COG0598     1 RELDALEELLDPE-----GFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTL---NYNE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 139 NNTILDIEQVSLLLYDNVLLSFQEKPGDVWQSVRGRLHtENRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEV 218
Cdd:COG0598    73 EEEELETGPLSIFLGPNFLITVRERPLDAFDDVRERLE-RGPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELED 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 219 TTLENPTPHVLHHIHSIKRELALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSE 298
Cdd:COG0598   152 ELFESPDNELLRRLYRLRRELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLD 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1305003196 299 LYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:COG0598   232 AYLSLISNRQNEIMKVLTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 80-372 5.83e-108

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 317.97  E-value: 5.83e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  80 WIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLETHEPnntILDIEQVSLLLYDNVLLS 159
Cdd:cd12822     1 WIDLEGPTEEELQLLAEEFGFHPLAIEDALNERQRPKIEEYDDYLFLVLRALRYDEEEL---ELETSELSIFLGKNFLVT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 160 FQEKPGDVWQSVRGRLHTeNRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSIKREL 239
Cdd:cd12822    78 VHEGPLRLIDEVIERLLS-DPKLLPKGPDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEEPRREVLRELFALRREL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 240 ALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVLTIIS 319
Cdd:cd12822   157 LRLRRILSPQREVLNRLLRRENELISEELRPYFRDVYDHLERLAELLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTIIT 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1305003196 320 SVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12822   237 TIFLPLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 56-372 1.62e-95

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 287.75  E-value: 1.62e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  56 IEAKEVSDIDEFLKTPQPEwATVRWIHVSN-TDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLE 134
Cdd:TIGR00383   6 IEKSRLIKIPFFEEFSQEL-NTVLWIDLIEpTDEERLAKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFFLNED 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 135 ThepnNTILDIEQVSLLLYDNVLLSFQEKPGDVWQSVRGRLHTeNRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILE 214
Cdd:TIGR00383  85 E----DDTFETEQVSFILGKNLLFTIHERELPAFDSIRERIRT-SQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 215 ELEVTTLENPTPHVLHHIHSIKRELALLRRIVWPMREVIDHLYREEG-GRIDDSTRPYLRDVYEHNIQIVEIIESYREMV 293
Cdd:TIGR00383 160 ELEDEIISGPTSTLMDEILSLRTELLALRRSLWPLRDVLNFLLRKTHlPIQTEEVREYLRDIYDHILSLLEMIETYRELL 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1305003196 294 SGLSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:TIGR00383 240 SSLMDLYLSLVNNKMNEIMKILTVVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 80-372 4.41e-79

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 244.38  E-value: 4.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  80 WIHVSN-TDSYIvGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLsmlkletHEPNNTILDIEQVSLLLYDNVLL 158
Cdd:cd12831     4 WVDFNNpTEEEI-KLLTSFFHFHPLAIEDCLHLLQRPKLDYYDDYQFLVL-------HAIDQEDLEAEEVNLFVGENYIV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 159 SFQEKPGDVWQSVRGRLHTEnrRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSIKRE 238
Cdd:cd12831    76 TFHKEPIREINEVWEKLKEK--KDKKLGTLYIAYMIIDKIVDDYFPIVYEIEDRLNEIEDNNVDSSNKKLMDEVFDIRSD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 239 LALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVLTII 318
Cdd:cd12831   154 LLKLRRTILPMRDLLYRILNSERLEGDKEQRAYFQDIYDHLLKLSEMLESNREMTADIRDNYESYNSNRMNSIMMTLTII 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1305003196 319 SSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12831   234 STIFMPLTFIAGIYGMNFEYMPELKWHYGYFVVLGIMLLIAIGMILWFKKKGWF 287
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 75-369 3.43e-74

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 232.21  E-value: 3.43e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  75 WATVRWIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLEthePNNTILDIEQVSLLLYD 154
Cdd:pfam01544   1 EQGFVWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLD---DSEEADELVTVSILLGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 155 NVLLSFQEKPGDVWQSVRGRLhtENRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHS 234
Cdd:pfam01544  78 NFLITVRHEPLPALDEVRKRL--TLLGGGPLDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDETNNELLRELAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 235 IKRELALLRRIVWPMREVIDHLYR-EEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMK 313
Cdd:pfam01544 156 LRRSLVYLRRSLLPQRDVLNRLLRrEDDPLLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMK 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305003196 314 VLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYP-VLWCVFILITAAMIFIFWRK 369
Cdd:pfam01544 236 VLTVVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPfVLILGLMILLAILLLFYFRR 292
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 80-372 4.23e-74

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 231.64  E-value: 4.23e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  80 WIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLETHEPnntILDIEQVSLLLYDNVLLS 159
Cdd:cd12830     4 WVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTARYVDHTE---EVETGETHVFVGPDFVVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 160 FQEKPGDVWQSVRGRLHTENRRIRKnGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSIKREL 239
Cdd:cd12830    81 VRHGAAGPLARVRARLEADPELLAL-GPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDRRDDIERIYRLKREV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 240 ALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKvltIIS 319
Cdd:cd12830   160 LEFRRAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMR---KIS 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305003196 320 S----VFIPlTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12830   237 AwaaiLAVP-TAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 80-371 6.77e-67

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 213.22  E-value: 6.77e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  80 WIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLkleTHEPNNTILDIEQVSLLLYDNVLLS 159
Cdd:cd11744     1 WIHCERLHDDDIRRVLEDNLHVPRALEDILLAESRPSFHPLDDNFMIILRGF---NMDENASPEDMLSVRILYFQGALIS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 160 FQEKPGDVWQSVRGRLHTEnrRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSIKREL 239
Cdd:cd11744    78 TREIPSRAFMEIRQRLREH--SKGPKSAASLLNQLIEGLNGKIDLYLETIEETLNELDVNDEEGHYDESTYNHIALQKAL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 240 ALLRRIVWPMREVIDHLYREEGgRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVLTIIS 319
Cdd:cd11744   156 ISIRRFIRPQQYALRDLIRSES-ELVTSRPHQYRFAHNNITRINETIEFYLGEVALLQDEIKHNRDEKTNKNSKLFTLVA 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1305003196 320 SVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGW 371
Cdd:cd11744   235 TIFLPTTFLAGLYGMNFEGMPGVESSMAFTWFCIALIVAFGLEWLLFKRKGF 286
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 80-371 1.58e-50

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 170.58  E-value: 1.58e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  80 WIHVSNTDSYIVGLLQHHFAFHTLTA-EDILHVPQRPRIEFFDDHLFvvlsMLKLETHEPNntiLDIEQVSLLLYDNVLL 158
Cdd:cd12821     1 WYDIDEPDDEIRRLLEELESSHLPNDlRDILLGVSFPRFEEVSGSGI----YIQLRKPQKD---ADTASFHFLITRDRLI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 159 SFQEKPGDVWQSVRGRLHTENRRIRKNGTGyLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSIKRE 238
Cdd:cd12821    74 TVRLDELPALDELRQDLRSGQMKSAKSAAE-LLFVLLGAIIKALLTGIDQFEEKLEELEWDLLEGNNAIKLDRILELRRE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 239 LALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVLTII 318
Cdd:cd12821   153 LLRLTNLIEPQQEVLMALQEAFAELLFSEDEEELRRTLDRIERLLQLIEEYEQELDTLQDIEEVVSSHRGNEIMKTLTVV 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1305003196 319 SSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGW 371
Cdd:cd12821   233 TTVFLPLTLIGGLWGMNFKNMPELEWKYGYLFVLGLIILSTAGLYLYLRRKGW 285
TmCorA-like_u3 cd12832
Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs ...
 94-372 7.99e-48

Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213366 [Multi-domain]  Cd Length: 287  Bit Score: 163.54  E-value: 7.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  94 LQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLETHEPNNTILDI-EQVSLLLYDNVLLSFQEKPGDVWQSVR 172
Cdd:cd12832    15 LARRYNLHETSLKDCLDPDHLPKYEEVDGVTFIILRVYTDKKRENADTIQELtTKIAIFVVDKFVITIHRTDLEFIANLK 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 173 GRLHteNRRIRKNGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTT-LENPTPHVLHHIHSIKRELALLRRIVWPMRE 251
Cdd:cd12832    95 EKWL--SGMHKCESPTELLLRIVKDALKTYEAPLEKLSEELDKYEEEVfLKKRKGSLLKRLYHLKRKASVIKRVLNLTQD 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 252 VIDHLYREEggriddSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGI 331
Cdd:cd12832   173 VIDKIDTPL------KSDPYTQDLRDLLIKLLSLYDELHENATNLLSLYISLSSQRTNEVMRVLTIFSVFFLPLTFIAGV 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1305003196 332 YGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12832   247 YGMNFKYMPELHWKYGYPATLLVMIVIVVGIYFWFKRKGWL 287
ZntB-like_1 cd12833
Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to ...
 79-372 8.59e-39

Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213367 [Multi-domain]  Cd Length: 290  Bit Score: 139.94  E-value: 8.59e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  79 RWIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKL-ETHEPNntildiEQVSLLLY--DN 155
Cdd:cd12833     3 LWLHLDYSDPEAQDWLEQSSGLPELVIDALLAEETRPRATRLGDGLLLNLRGVNLnPGADPE------DMVSIRLWitPG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 156 VLLSFQEKPGDVWQSVRGRLhTENRRIRknGTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSI 235
Cdd:cd12833    77 RIISTRRRRLLAVDDIREAL-EAGKGPK--SPGDFLAALAERLTDRMEDVIDELEDRLDELEERVLEEEDEELRGELAEL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 236 KRELALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVL 315
Cdd:cd12833   154 RRQAIALRRYLAPQRDALERLAREDLPWLSDDDRLRLREAADRLTRYIEDLDAIRERAAVLQEELTNRRAEQMNRRMYVL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305003196 316 TIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12833   234 SIVAAIFLPLGFLTGLLGINVGGIPGAENPWAFWIFCGLLVVLAVGLLLLFRRKKWL 290
EcCorA_ZntB-like_u1 cd12826
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 190-372 6.21e-35

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA-ZntB_like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB_like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213360  Cd Length: 281  Bit Score: 129.61  E-value: 6.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 190 LLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSIKRELALLRRIVWPMREVIDHLYREEGGRIDDSTR 269
Cdd:cd12826    99 FLYDFLEYLIKDDLEYLEKYEEKLEELEEEILDGKLKNFNERILKIRKELLRLNSYYEQLMDIGEELEENENDLFDEEEL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 270 PYLR------DVYEHNIQiveiieSYREMVSGLSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPELN 343
Cdd:cd12826   179 RLFRlfsdrvERLHDNVQ------MLREYSLQIRELYQSQIDIRQNRIMKILTVVTTIFLPLTLITGWYGMNFTNMPELH 252

                         170       180
                  ....*....|....*....|....*....
gi 1305003196 344 WTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12826   253 WKYGYPVVIILSILIVVIEIIYFKKKKWL 281
Alr1p-like cd12829
Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the ...
 80-367 1.71e-34

Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213363 [Multi-domain]  Cd Length: 305  Bit Score: 128.92  E-value: 1.71e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  80 WIHVSN-TDSYIVGLLqHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLETHEPNNtILDIEQVSLLLYDNVLL 158
Cdd:cd12829     1 WLDVQSpTDDDMRAIG-KLFPIHPLTLEDILSQDTREKVELFPNYYFISFRAIESDSELDEN-VLEPVNVYIVVFREGIL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 159 SFQEKPGDVWQSVRgrlhtenRRIRKNGTGYL------LYALLDELVDKCFPVLEQYG---DILEELEVTTLENPTPHVL 229
Cdd:cd12829    79 TFHFKPLDHIERVR-------KRIRLLSDSHLlssdwvLYALLDSIVDSFFPLVDSIEkevDSIDELVLLISSSDQSDLL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 230 HHIHSIKRELALLRRIVWPMREVIDHLYR----EEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAIS 305
Cdd:cd12829   152 RRIGDLRRRVTSLLRLLFAKSDVLKQLLKrlmkKTFVSPDSEVAIYLGDVQDHILTLLQKLNHYEDLLSRSHSNYLAQLS 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1305003196 306 -------NRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKyMPELNWTWAYPVLWCVFILITAAMIFIFW 367
Cdd:cd12829   232 lemsqesNGTDKAMLRLTVIATIFLPLQLITGLFGMNVK-VPGQDIESLYWFFGIVIVAIMVLVAIVVV 299
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 80-372 1.58e-29

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 115.29  E-value: 1.58e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  80 WIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLETHEPNNTILDIEQVSLLLYDNVLLS 159
Cdd:cd12827     1 WINVVNPTEEEIEQLAEKYGIPEDFLTYALDEEERSRIEYDDDTDYLLIILDVPVEEEEDDDEYETIPLGIILTKDRLIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 160 FQEKPGDVWQSVRGRLHTENRRIRKNgtgYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHSIKREL 239
Cdd:cd12827    81 ICNHETDLLDDFLEGRVKNFDTSSKT---RFLLQILYRIATSYLKYLRQINKERDELEQELRKSTKNKELFQLLDLEKSL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 240 ALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVLTIIS 319
Cdd:cd12827   158 VYFSTSLKSNEIVLEKLKRSRSLKLDEEDKELLEDVIIENKQAIEMAEIYSDILSGLMDAFASVISNNLNNVMKFLTSIT 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1305003196 320 SVFIPLTFIAGIYGMNFKyMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12827   238 IVLTIPTIITGFYGMNVP-LPFADSPYAFWIILLISLLLSVIVALILRRKKYF 289
EcCorA-like_u1 cd12837
uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A ...
 190-372 1.97e-25

uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A uncharacterized subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA_ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA_ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213371 [Multi-domain]  Cd Length: 298  Bit Score: 104.15  E-value: 1.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 190 LLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHV------LHHI-HSIKRELALLRRIvwpmRE-------VIDH 255
Cdd:cd12837   106 VLLGLLEAIVDRLADVLERVGADLDRLSRRIFRSSAKRRrrasrdLRSVlRRIGRAGDLLSKI----REsllslgrLLSF 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 256 LYREEGGRIDDSTRPYL----RDVyehniqiveiiesyremvSGLSElYMSAISNRM---------------NEIMKVLT 316
Cdd:cd12837   182 LSANAADWLSKELRARLktlqRDV------------------ASLSE-HATFLSNKIqflldatlglinieqNNIIKIFS 242

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1305003196 317 IISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12837   243 VASVVFLPPTLIASIYGMNFKHMPELDWPFGYPLALGLMVLSAVLPLLWFKRRGWL 298
EcCorA-like cd12825
Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the ...
 207-372 4.87e-24

Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB_like(EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporters Escherichia coli, Salmonella typhimurium, and Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213359 [Multi-domain]  Cd Length: 287  Bit Score: 100.08  E-value: 4.87e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 207 EQYGDILEEL---------EVTTLENPTPHVLHHIHSIKRELALLRRIVWPMREVIDHLYReeGGRIDDSTRPYLRDVYE 277
Cdd:cd12825   115 DYLADILENIskkikqlsrEILEEKQFSEEDLDALTKLNENNITLRESLIEKQRIITLLLK--SPRENSDTKEKLKIELR 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 278 HNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFIL 357
Cdd:cd12825   193 DLSSLLDHTTFNFDKLDDLKNNILGKIELEQNKIIKIFTVVTVCFLPPTLIASIYGMNFKNMPELKWSYGYPFALILMIL 272

                         170
                  ....*....|....*
gi 1305003196 358 ITAAMIFIFWRKGWL 372
Cdd:cd12825   273 STILPLLYFKRKGWL 287
HpCorA-like cd12836
Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the ...
 296-372 8.70e-23

Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporter Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+); CorA plays an important role in the viability of this pathogen. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB (members of the EcCorA_ZntB-like family) form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213370 [Multi-domain]  Cd Length: 288  Bit Score: 96.56  E-value: 8.70e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1305003196 296 LSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:cd12836   212 LQNTFLGLINIEQNKIIKIFTVATVIFMPPTLIASIYGMNFKFMPELDWKYGYPFALLLMVISSILPLLYFKKKKWL 288
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
 148-372 1.54e-21

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 93.09  E-value: 1.54e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 148 VSLLLYDNVLLSFQEKPGDVWQSVRgrLHTENRRIRKNGTGYLLYALLDELVdkcfpvlEQYGDILEELEvTTLENPTPH 227
Cdd:cd12835    64 VAFTLRDDRLITLREEELPVFRLLR--LRARRGPGEVSDPKDLLLDLFEQKV-------EYLADIIEDIY-RDLERVSRE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 228 VLHhihsiKRELALlrrivwpmREVIDHLYREE--GGRID----DSTRP------YLRDVYEHNIQIVEI---IESYR-- 290
Cdd:cd12835   134 VLE-----ENDEDL--------EEALGRLARQEdlNGKIRlclmDTQRAlsfllrTRRLSDEQLEDAREIlrdIESLLph 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 291 -----EMVSGLSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYPVLWCVFILITAAMIFI 365
Cdd:cd12835   201 tqflfDKINFLMDAAMGFINIEQNKIIKIFSVAAVVFLPPTLIASIYGMNFDFMPELDWKFGYPMAIGLMILSAIAPYLY 280


                  ....*..
gi 1305003196 366 FWRKGWL 372
Cdd:cd12835   281 FKRKGWL 287
ZntB-like cd12824
Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging ...
 80-374 1.70e-18

Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213358 [Multi-domain]  Cd Length: 290  Bit Score: 84.88  E-value: 1.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  80 WIHVSNTDSYIVGLLQHHFAFHTLTAEDILHVPQRPRIEFFDDHLFVVLSMLKLETHEPNNTILDIEqvsLLLYDNVLLS 159
Cdd:cd12824     4 WYHCDRADPAIRSWLEDNTHLPEATVDHLLAPVRFPHFEPVDDGFLLSLRGIRMDEAASPSDMADLR---ILIGQGAAVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 160 FQEKPGdvwqsvrgRLHTENRRIRKNGTGY-----LLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLHHIHS 234
Cdd:cd12824    81 VRSGPS--------RAVDELRRALRDHSSLksladLLAQMISGMTKRLELVIFDLTETLDEVEDNLLDGGTAPPPYALIA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 235 IKRELALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNEIMKV 314
Cdd:cd12824   153 LQRRLFRIRRQIRPQQQALRPLITDPAELLVTSDRETLRRASNNVTRYLETLDFCRTRVALLQDEIKAQRDEKTTRSSLL 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 315 LTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAypvlwcvFILITAAMIFIFWRKGWLNR 374
Cdd:cd12824   233 LTVVATVFLPLTFITGLLGMNVGGIPDVESPMG-------FWWVTGLSILVALLAWLLLR 285
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
266-372 1.78e-16

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 79.38  E-value: 1.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 266 DSTRPYLRDVYE---HNiqiveiiESYREMVSGLSELYMSAISNRMNEIMKVLTIISSVFIPLTFIAGIYGMNFKYMPEL 342
Cdd:PRK11085  214 EQAREILRDIESllpHN-------ESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPEL 286

                          90       100       110
                  ....*....|....*....|....*....|
gi 1305003196 343 NWTWAYPVLWCVFILITAAMIFIFWRKGWL 372
Cdd:PRK11085  287 KWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
ZntB_u1 cd12834
Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like ...
 79-369 5.46e-10

Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213368 [Multi-domain]  Cd Length: 290  Bit Score: 59.52  E-value: 5.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196  79 RWIHVSNTDSYIVGLLQHHF-----AFHTLTAEDilhvpQRPRIEFFDDHLFVVLSMLKLETHEPNntildiEQVSLL-- 151
Cdd:cd12834     3 LWLHFNLADARARQWIAAHPalpeaARALLLSGD-----TSTRLEVDDDALYGVLNDLERDFAEAS------TDVGTLrf 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 152 -LYDNVLLSFQEKPGDVWQSVRGRLhTENRRIRKngTGYLLYALLDELVDKCFPVLEQYGDILEELEVTTLENPTPHVLH 230
Cdd:cd12834    72 aVTPRLLITARRQPLRSVDRLRQAV-ERGLRFRS--PADLLEHLLREQADTLSRIVRELTDELDRIEDRLLSGRLRRERR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 231 HIHSIKRELALLRRIVWPMREVIDHLYREEGGRIDDSTRPYLRDVYEHNIQIVEIIESYREMVSGLSELYMSAISNRMNE 310
Cdd:cd12834   149 ELGALRRRLVRLHRLLAPEPAALFRLLRRPPDWLPDADLETLRRLTERLDALDRDLVALQERARLLQEEIAARLAEQTNR 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1305003196 311 IMKVLTIISSVFIPLTFIAGIYGMNFKYMPELNWTWAYpvlWCVFILITAAM----IFIFWRK 369
Cdd:cd12834   229 SLYILSVVTALLLPPTLVTGLFGMNTGGLPLAEGPHGF---WIAVALALLAAglayLLLRRLG 288
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 211-371 3.65e-08

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 54.56  E-value: 3.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 211 DILEELEvttlENPTPHVLHHIHSIKRELALLRRIVWPMREVIDHLYREEggriDDSTRPYL-----------RDVYEHN 279
Cdd:cd12823   139 PLLDELT----DKISTSNLERLLPLKRRLVELETRVQKVRDALEELLDDD----EDMADMYLtdkaagperleSSRKEDD 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 280 IQIVEII-ESY----REMVSGLSEL---------YMSAI--SNRmNEIMK---VLTIISSVFIPLTFIAGIYGMNFK-YM 339
Cdd:cd12823   211 HEEVEMLlEAYlqqvDELLNKLEELreyiddteeLINLIldSRR-NQLMRlelKLSIGTLSLAVGTLVAGLFGMNLPsGL 289

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1305003196 340 PELNWTWAYPVLWCVF--ILITAAMIFIFWRKGW 371
Cdd:cd12823   290 EESPYAFWIVTGGSVVgsILIFIVVLRYLRRKRL 323
zntB PRK09546
zinc transporter ZntB;
198-372 3.27e-07

zinc transporter ZntB;


Pssm-ID: 181941  Cd Length: 324  Bit Score: 51.54  E-value: 3.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 198 LVDKCFPVLEQYGDILEEL--EVTTLENptpHVLHHIHSIKRELALLRR--IVW-----PMREVIDHLYREEGGRIDDST 268
Cdd:PRK09546  144 LVDVCDALTDHASEFIEELhdKIIDLED---NLLDQQIPPRGELALLRKqlIVMrrymaPQRDVFARLASERLPWMSDDD 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305003196 269 RPYLRDVYEhniqiveiiesyrEMVSGLSELYMS---------AISNRMNEIMKVLTIISS----VFIPLTFIAGIYGMN 335
Cdd:PRK09546  221 RRRMQDIAD-------------RLGRGLDDLDACiartavladEIASVMAEAMNRRTYTMSlmamVFLPTTFLTGLFGVN 287

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1305003196 336 FKYMPELNWTWAYpVLWCvFILITAAMIFIFW--RKGWL 372
Cdd:PRK09546  288 LGGIPGGGWPFGF-SIFC-LLLVVLIGGVAWWlkRSKWL 324
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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