|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
16-451 |
3.98e-84 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 264.81 E-value: 3.98e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 16 LNRRILALAVPAFGALIAEPIFVLTDSALIGQLGKA-ELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAW 94
Cdd:cd13136 1 LHREILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 95 QIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVAT 174
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 175 VGTLVNIALNWLLIYPVGWGVAGSATGTSLTQWGMAAALGAVMMRGTREHA---VRWAPDVAGMRSVLSLGSWLMLRTLS 251
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGkslSRRLPSKAALKRLFKLNRDIFIRTLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 252 MRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDlnveseRAKVRQLKNRLLRMSLIY 331
Cdd:cd13136 241 LLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGD------RKAARRVARRLLQWGLGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 332 GVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKYLAIGCFIMLVMYVPVMLGL 411
Cdd:cd13136 315 GVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLL 394
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1317672449 412 HWavgagtmdaLAGYCGLWAAYILyFQGIRAVIFGRRARS 451
Cdd:cd13136 395 VP---------LWGNHGLWLALIL-FMLLRGLTLALRLPR 424
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
13-448 |
5.88e-77 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 246.21 E-value: 5.88e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 13 EPSLNRRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRR 92
Cdd:COG0534 3 EGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 93 AWQIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKV 172
Cdd:COG0534 83 ARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 173 ATVGTLVNIALNWLLIYPVGWGVAGSATGTSLTQWGMAAALGAVMMRGTREHAVR---WAPDVAGMRSVLSLGSWLMLRT 249
Cdd:COG0534 163 MLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRlrdLRPDRKILKRILRIGLPAGLQQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 250 LSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDlnveseRAKVRQLKNRLLRMSL 329
Cdd:COG0534 243 LAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGD------YDRARRAARLALLLAL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 330 IYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKYLAIgcfIMLVMYVPVML 409
Cdd:COG0534 317 GIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMI---ISLLRLWLVRL 393
|
410 420 430
....*....|....*....|....*....|....*....
gi 1317672449 410 GLHWAVGAGTMDALagycGLWAAYILYFqGIRAVIFGRR 448
Cdd:COG0534 394 PLAYLLAFLGLGLT----GVWLALPIGE-VLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
26-368 |
7.58e-58 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 194.00 E-value: 7.58e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 26 PAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVDGVWVAF 105
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 106 GLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLVNIALNW 185
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 186 LLIYPV--GWGVAGSATGTSLTQWGMAAALGAVMMRGtREHAVRWA----PDVAGMRSVLSLGSWLMLRTLSMRIASLLT 259
Cdd:TIGR00797 161 ILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKA-KKIGLKWEgllkPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 260 VFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLNveseraKVRQLKNRLLRMSLIYGVITGLIC 339
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPK------RAKEVARVALKLSLLLGLVLAIIL 313
|
330 340
....*....|....*....|....*....
gi 1317672449 340 PLIGFFGSWIFTQDAQVAFLFTIATVIIA 368
Cdd:TIGR00797 314 ILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
18-454 |
3.32e-55 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 189.65 E-value: 3.32e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIG 97
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 98 VDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGT 177
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 178 LVNIALNWLLIYPV----GWGVAGSATGTSLTQWGMAAALGAVMMRG---TREHAVRWAPDVAGMRSVLSLGSWLMLRTL 250
Cdd:cd13137 161 VLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLLFLLLRGrlpIKISFKGFRLDRKIIKKLLRIGLPAGLEQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 251 SMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLnvesERAkvRQLKNRLLRMSLI 330
Cdd:cd13137 241 LRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDP----DEA--RRYGKRALRLGVL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 331 YGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKYLAIGCFI-MLVMYVPVML 409
Cdd:cd13137 315 FMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLIsMWLVRLPLAY 394
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1317672449 410 GLHWAVGAGTMdalagycGLWAAYILYfQGIRAVIFGRRARSDVW 454
Cdd:cd13137 395 LLGFVLGLGLT-------GIWLAMFVD-TIVRAILLLYRFRKGKW 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-454 |
1.05e-39 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 148.06 E-value: 1.05e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 14 PSLNRRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRA 93
Cdd:cd13133 1 PGGYREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 94 WQIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVA 173
Cdd:cd13133 81 GRVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 174 TVGTLVNIALNWLLIYPVG----WGVAGSATGTSLTQWGMAAALGAVMMRGTRE----HAVRWAPDVAGMRSVLSLGSWL 245
Cdd:cd13133 161 LVMVVVNIVLDYALIFGKLgfpaMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRrrfgLRRAWRFDRELLRRILRLGLPS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 246 MLRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGerdlnvESERAKVRQLKNRLL 325
Cdd:cd13133 241 GLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALG------AGRPDLAMRVTRRGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 326 RMSLIYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATV---IIALGQPIAAYVFTLDGILMGAQDVKYLAIGCFIMLV 402
Cdd:cd13133 315 KLALAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPllrFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAW 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1317672449 403 MYvpvMLGLHWAVGAGTMDALagycGLWAAYILYFqGIRAVIFGRRARSDVW 454
Cdd:cd13133 395 LY---LLPPAYLLVVLGAGLA----GAWTVETVYV-IVLALIFLLRFRSGKW 438
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
15-416 |
2.71e-38 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 143.80 E-value: 2.71e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 15 SLNRRILALAVPAFGALIAEPIFVLTDSALIGQL-GKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRA 93
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 94 WQIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVA 173
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 174 TVGTLVNIALNWLLIYPVGWGVAGSATGTSLTQWGMAAALGAVMMRG---TREHAVRWAPDVAGMRSVLSLGSWLMLRTL 250
Cdd:cd13143 161 LIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGkslLKLSLLRFKLSLKIIKEILALGFPSFLMQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 251 SMRIASLLTVFVVARFGTE-HTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLNveseraKVRQLKNRLLRMSL 329
Cdd:cd13143 241 SSSVVTIVLNLTLLGYGGDiGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYD------RVKQALKLALIVAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 330 IYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKY-LAIGCFIMLVMYVPVM 408
Cdd:cd13143 315 IYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRaALLSLLRQGLFLIPLL 394
|
....*...
gi 1317672449 409 LGLHWAVG 416
Cdd:cd13143 395 LILPRLFG 402
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
24-435 |
6.92e-36 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 137.07 E-value: 6.92e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 24 AVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVDGVWV 103
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 104 AFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLVNIAL 183
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 184 NWLLIY---PVGWGVAGSATGTSLTQWGMAAALGAVMMRGTREHAVRW---APDVAGMRSVLSLGSWLMLRTLSMRIASL 257
Cdd:cd12082 161 DPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLsllKPDLELLRRLLRIGLPSAIQNSLLSLGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 258 LTVFVVARFGTEH-TAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLnveserAKVRQLKNRLLRMSLIYGVITG 336
Cdd:cd12082 241 IIVAIVAAFGGAAaLAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNF------DRARRITWVALLIGLLIGAVLG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 337 LICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKYLAIgcfIMLVMYVPVMLGLHWAVG 416
Cdd:cd12082 315 LLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLI---VSLLSYWVVRLPLAYVLA 391
|
410
....*....|....*....
gi 1317672449 417 AGTMDALAGYCGLWAAYIL 435
Cdd:cd12082 392 YLGLGLYGIWLALVISLIL 410
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
18-416 |
8.36e-36 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 137.25 E-value: 8.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIG 97
Cdd:cd13131 3 RALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 98 VDGVWVAFGLGMLLMIAgYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGT 177
Cdd:cd13131 83 RQGLWLALLLSLPLMLL-LWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 178 LVNIALNWLLIYpvGW------GVAGSATGTSLTQWGMAAALGAVMMRGTREHAVR-----WAPDVAGMRSVLSLGSWLM 246
Cdd:cd13131 162 VLNIPLNYVLIF--GKfglpalGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRlfarfWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 247 LRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNL-FLYALdSLAIAAQALLGKELGERDLnveserAKVRQLKNRLL 325
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLlFMVPL-GISMAATVRVGFALGAGDP------ADARRAGLVGL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 326 RMSLIYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKYLAIgcfIMLVMYV 405
Cdd:cd13131 313 GLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFL---LALISYW 389
|
410
....*....|.
gi 1317672449 406 PVMLGLHWAVG 416
Cdd:cd13131 390 GIGLPLGYLLA 400
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
18-448 |
1.48e-34 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 133.74 E-value: 1.48e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQ-LGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQI 96
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 97 GVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVG 176
Cdd:cd13138 83 VGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 177 TLVNIALNWLLIYPVGWGVAGSATGTSLTQwGMAAALGAVMMRGTREHAV----RWAPDVAGMRSVLSLGSWLMLRTLSM 252
Cdd:cd13138 163 CVLNIILDLLFIAVFHMGVAGAALATVIAQ-AISVLLALYYLRKKKLPFKlslkDFRFDKEILKEILKIGLPSALQQSLV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 253 RIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLnvesERAKvrqlknRLLRMSLIYG 332
Cdd:cd13138 242 SISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKI----ERAK------KGLRTGIIIS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 333 VITGLICPLIGFFGS----WIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKY-LAIGCFIMLVMYVPV 407
Cdd:cd13138 312 LIIGLIIILLVFFFApqllGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFpMIISILRLWLVRIPL 391
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1317672449 408 MLGLHWAVGagtmdalAGYCGLWAAYIL--YFQGIRAVIFGRR 448
Cdd:cd13138 392 AYLLSRLTG-------LGLFGIWLAMPIsnILSAIICIIYYRK 427
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-456 |
1.97e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 128.00 E-value: 1.97e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 17 NRRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQI 96
Cdd:cd13134 2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 97 GVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVG 176
Cdd:cd13134 82 AGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 177 TLVNIALNWLLIYPVG----WGVAGSATGTSLTQWGMAAALGAVMMRGTREHAVR---WAPDVAGMRSVLSLGSWLMLRT 249
Cdd:cd13134 162 NILNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLkdlRPFPKKLLKKILKIGLPSAGEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 250 LSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNL-FLYALdSLAIAAQALLGKELGERDLNveseraKVRQLKNRLLRMS 328
Cdd:cd13134 242 LSYNLSQTVITAFIARLGTAALAARTYASNISMFvFLFSL-AIGQATQIIVGHLVGAGDFD------EAYKRVLKSLKIG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 329 LIYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKY-LAIGCFIMLVMYVPV 407
Cdd:cd13134 315 LLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFpVLIGIISMWGISVPL 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1317672449 408 --MLGLHWAVgagtmdalaGYCGLWAAYILYfQGIRAVIFGRRARSDVWMK 456
Cdd:cd13134 395 ayLLGIVLGL---------GLLGVWIAFAAD-EWVRGIIMLWRWRSGKWIK 435
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-435 |
4.35e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 109.97 E-value: 4.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 15 SLNRRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAW 94
Cdd:cd13142 8 SILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKAN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 95 QIGVDGVWVAFGLGMLLMIAGYAFADPLL-RGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVA 173
Cdd:cd13142 88 KVAGQTFSFVIILSLILAVLGYILSRPLLlLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIM 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 174 TVGTLVNIALNWLLIYPVG----WGVAGSATGTSLTQwGMAAALGAVMMRGTREHA-VRWA---PDVAGMRSVLSLGSWL 245
Cdd:cd13142 168 FGSVLLNVILDPLLIFGIGpfpgLGVAGAALATVISR-GIAAVIGLYLLFKGRVGLkISLRdlkPDWEWLKKIFRIGLPS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 246 MLRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERdlnvESERAKVRQLKNRLL 325
Cdd:cd13142 247 SIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAG----QIDRAEEIVKKAALL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 326 RMS--LIYGVITGLIC-PLIGFfgswiFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKY-LAIGCFIML 401
Cdd:cd13142 323 IFLilVIGGVLAFLFAePIVRV-----FINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTaMIISILRLW 397
|
410 420 430
....*....|....*....|....*....|....
gi 1317672449 402 VMYVPVMLGLHWAVGAGTMdalagycGLWAAYIL 435
Cdd:cd13142 398 VIRIPLAYLLAYVLGLGVT-------GIWIAMAI 424
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-401 |
1.84e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 108.08 E-value: 1.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 15 SLNRRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAW 94
Cdd:cd13139 11 SLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 95 QIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVAT 174
Cdd:cd13139 91 FAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 175 VGTLVNIALNWLLIYPVG----WGVAGSATGTSLtqwGMAAALGA---VMMRGTREHAVR---WAPDVAGMRSVLSLGSW 244
Cdd:cd13139 171 LANGLNIILDPLFIFGLGpipaMGVTGAAIATTI---GRSIGVLYqlyHLFKGKGRIQIRrrhLKLDWAIIKKIIKIAVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 245 LMLRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERdlnvESERAKvrQLKNRL 324
Cdd:cd13139 248 GILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAG----QPDRAE--KSVWRA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 325 LRMSLIYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVK---YLAIGCFIML 401
Cdd:cd13139 322 GKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKtptLINLVGFWLF 401
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
18-359 |
6.52e-24 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 103.74 E-value: 6.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATL-VTTVVGLMNFLAySVTPAVARAFGEKNLRRAWQI 96
Cdd:PRK01766 12 RQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIwLPVILFGHGLLL-ALTPIVAQLNGAGRRERIAHQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 97 GVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILaqvgTLRGLQDTVTPLKVATV- 175
Cdd:PRK01766 91 VRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQ----VLRSFIDGLGKTKPTMVi 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 176 ---GTLVNIALNWLLIY---------PVGWGVAgsatgTSLTQWGMAAALGAVMMRGTREHAVR-----WAPDVAGMRSV 238
Cdd:PRK01766 167 gflGLLINIPLNYIFIYgkfgfpelgGVGCGVA-----TAIVYWVMFLAMLIYIKRARRFRDFRlfkglYKPDWAVIKRL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 239 LSLG-----SWLMLRTLSMriaslLTVFVVARFGTEHTAAYQLGMGvFNLFLYALD-SLAIAAQALLGKELGERDLnves 312
Cdd:PRK01766 242 LKLGlpiglAIFFEVSLFA-----VVTLLVSPLGTVTVAAHQIALN-FSSLLFMLPlSLAMALTIRVGFELGAGRT---- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1317672449 313 ERAKVRQlknrllRMSLIYGVITGLICPLIGFFG----SWIFTQDAQVAFL 359
Cdd:PRK01766 312 LDARQYA------YIGLAVGLGMALLTAIFLVLFreqiALLYTDDPEVVAL 356
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-408 |
2.81e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 101.52 E-value: 2.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 20 ILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVD 99
Cdd:cd13145 11 IRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 100 GVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLV 179
Cdd:cd13145 91 GLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 180 NIALNWLLIYPVGW----GVAGSATGTSLTQWGMAAALGAVMMRGTREHAVRW---APDVAGMRSVLSLGSWLMLRTLSM 252
Cdd:cd13145 171 NIILDPLFIFGGGGipamGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLrdfIPRLDVYKEILKQGFPASLNMMTI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 253 RIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLNveseraKVRQlknrLLRMSLIYG 332
Cdd:cd13145 251 GLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYD------RVRE----TYKKALKYG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 333 -VITGLICPLIGFFGSW---IFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKY-LAIGCFIMLVMYVPV 407
Cdd:cd13145 321 fVIMVVATVFLLFFAEPlmsLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFaLWIGLYRQLVGPALV 400
|
.
gi 1317672449 408 M 408
Cdd:cd13145 401 F 401
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-425 |
4.56e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 100.94 E-value: 4.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 20 ILALAVPAFGALIAEPIFVLTDSALIGQLGKAE---LAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQI 96
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDPSDpalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELDQA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 97 GVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVG 176
Cdd:cd13146 90 ADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 177 TLVNIALNWLLIYPVGWGVAGSATGTSLTQWGMAAALGAVMMRGTREHAVRWAP---DVAGMRSVLSLGSWLMLRTLSMR 253
Cdd:cd13146 170 TVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLsniSSSVIVEILRVGLPQMLLQLISS 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 254 IASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLnvesERAKVrqlknrLLRMSLIYGV 333
Cdd:cd13146 250 ISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNY----DRMLQ------ILMTAVILGI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 334 ITGLICPLIGFFGS-WI---FTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKY-LAIGCFIMLVMYVPVM 408
Cdd:cd13146 320 VVVLVLVLGYVLVApWLfslFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPsLLLTLIRHVFLSVPVV 399
|
410
....*....|....*..
gi 1317672449 409 LGLHWAVGAGTMDALAG 425
Cdd:cd13146 400 YLLAYVFGKGITGVYFG 416
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
26-186 |
8.77e-23 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 94.55 E-value: 8.77e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 26 PAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVDGVWVAF 105
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 106 GLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLVNIALNW 185
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 1317672449 186 L 186
Cdd:pfam01554 161 L 161
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-370 |
2.77e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 98.53 E-value: 2.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 13 EPSLNRRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRR 92
Cdd:cd13149 4 EGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 93 AWQIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLhhSLWGIPPMMIILAQVGT--LRGLQDTVTPL 170
Cdd:cd13149 84 AKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYM--AIWYLGLVFLVLPMVGNaiIRATGDTKRPS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 171 KVATVGTLVNIALNWLLIYPVG----WGVAGSATGTSLTQ-WGMAAALGAVMMRGTREHAVRWAPDVAG--MRSVLSLGS 243
Cdd:cd13149 162 LVMLGAALVNVILDPILIFGFGpipgMGIAGAAIATVISRaLGLGAALYFLHYHHRLIDFSEPSLKALFrsWKDILSIGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 244 WLMLRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLNveseraKVRQLKNR 323
Cdd:cd13149 242 PAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYE------RVQEGLKI 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1317672449 324 LLRMSLIYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALG 370
Cdd:cd13149 316 SLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIG 362
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-413 |
2.16e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 96.15 E-value: 2.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 15 SLNRRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAW 94
Cdd:cd13144 5 PVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEAN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 95 QIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVAT 174
Cdd:cd13144 85 KAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 175 VGTLVNIALNWLLIY----PVGWGVAGSATGTSLTQwgMAAALGAVMMRGTREHAV-----RWAPDVAGMRSVLSLGSWL 245
Cdd:cd13144 165 IGAIINIILDPILIFglfgFPAMGIAGAAIATVIGQ--ILAMFLAFFFLLRKNKDVqpdlrLFRPSLRIIKEIYAVGLPS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 246 MLRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDlnveSERAKvrqlknRLL 325
Cdd:cd13144 243 IIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGN----KDRIR------EAI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 326 RMSLIY-GVITGLICPLIGFFGSWI---FTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKY-LAIGCFIM 400
Cdd:cd13144 313 KYAILIaVVIMLAGGLLFQLFPDQLlglFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYsLIISVARQ 392
|
410
....*....|....*....
gi 1317672449 401 LVMYVPV------MLGLHW 413
Cdd:cd13144 393 LVVLLPLawllakMFGLNG 411
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-371 |
3.99e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 95.28 E-value: 3.99e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIG 97
Cdd:cd13140 5 KTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 98 VDGVWVAFGLGMLLMIAGYAFADPLLR--GLGAtDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATV 175
Cdd:cd13140 85 RNALQLNLLLGILYGLLLLLFAKPLIGffNLGD-AEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 176 GTLVNIALNWLLIYPVG----WGVAGSATGTSLTQWGMAAALGAVMMRGTREH---AVRWAPDVAGMRSVLSLGSWLMLR 248
Cdd:cd13140 164 GLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFlkiRILKRPDRKYIKEILKLGLPVALQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 249 TLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLNveseraKVRQLKNRLLRMS 328
Cdd:cd13140 244 SILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYD------RIRKGYKTALKIA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1317672449 329 LIYGVITGLIcpLIgFFGSWI---FTQDAQVAFLFTIATVIIALGQ 371
Cdd:cd13140 318 SAIGLFATLL--LF-FFGEPLfslFIPDPETIAIGVDYLRILGFSQ 360
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
18-430 |
3.50e-20 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 92.25 E-value: 3.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVT-TVVGLMNFLAYSVTPAVARAFGEKNLRRAWQI 96
Cdd:cd13132 3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANvTGFSILLGLASALDTLCGQAFGAKNYKLVGVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 97 GVDGVWVAFgLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGlQDTVTPLKVAT-V 175
Cdd:cd13132 83 LQRALVILL-LCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQA-QGIVLPLVYISlV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 176 GTLVNIALNWLLIYPVGWGVAGSATGTSLTQWGMAAALGAVMMRgTREHAVRWapdvaGMRSVLSLGSWLMLRTLSmrIA 255
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFF-SKGHKATW-----GGFSREAFRGWGPFLKLA--IP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 256 SLL-----------TVFVVARF-GTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDlnveSERAKvrqlknR 323
Cdd:cd13132 233 SALmlclewwafeiLVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGN----PKRAK------L 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 324 LLRMSLIYGVITGLICPLIGFFG----SWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKYLAIgcfI 399
Cdd:cd13132 303 AAIVALILSLVIGVVVAILLLVLrdvwAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAY---V 379
|
410 420 430
....*....|....*....|....*....|....*
gi 1317672449 400 MLVMY----VPVMLGLHWAVGAGTMdalagycGLW 430
Cdd:cd13132 380 NLVAYyligLPVGLLLAFVLGLGLK-------GLW 407
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
23-387 |
6.47e-19 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 88.64 E-value: 6.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 23 LAVPAFGALIAEPIFVLTDSALIGQL-GKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVDGV 101
Cdd:PRK10367 14 LALPMIFSNITVPLLGLVDTAVIGHLdSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALARALVQPL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 102 WVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLVNI 181
Cdd:PRK10367 94 LLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGNILNI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 182 ALNWLLIYPVGWGVAGSATGTSLTQW-----GMAAALGAVMMRGTREHAVRWAPDvAGMRSVLSLGSWLMLRTLSMRIAS 256
Cdd:PRK10367 174 VLDLWLVMGLHMNVQGAALATVIAEYatlliGLLMVRKVLKLRGISLEMLKTAWR-GNFRRLLALNRDIMLRSLLLQLCF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 257 LLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLNVESE--RAKVRQLKNRLLRMSLIYGVI 334
Cdd:PRK10367 253 GAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQLLDvwRAACRQSGIVALLFSLVYALA 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1317672449 335 TGLICPLIGffgswIFTQDAQVAFLFTIATVIIALgqpIAAYVFTLDGILMGA 387
Cdd:PRK10367 333 GEHIIALLT-----SLPQIQQLADRYLIWQVILPL---VGVWCYLLDGMFIGA 377
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-386 |
8.34e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 85.45 E-value: 8.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 15 SLNRRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAW 94
Cdd:cd13141 8 SIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEAN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 95 QIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHhslWGIPPMMIILAQVG---TLRGLQDtVTPLK 171
Cdd:cd13141 88 AVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLY---WFIPSLALQFILTVlgaALRGTGI-VKPFM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 172 VATVGTLV-NIALNWLLIYpvGW------GVAGSATGTSLtqwgmAAALGAVMM-----RGTREHAVR---WAPDVAGMR 236
Cdd:cd13141 164 VIQILAVLlNIILAPILIT--GWgtgralGVAGAGLASSI-----SVAIAVVLLlyyflRLEKYLRLDlalWRPDLPTWK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 237 SVLSLGSWLMLRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLnveserAK 316
Cdd:cd13141 237 RLLKIGLPSGGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNY------DR 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 317 VRQLKNRLLRMSLIYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMG 386
Cdd:cd13141 311 VRETFRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQA 380
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
20-403 |
1.88e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 81.05 E-value: 1.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 20 ILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVD 99
Cdd:cd13147 11 IIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 100 GVWVAFGLGMLLMIAGYAFADPLLRGLGAtDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLV 179
Cdd:cd13147 91 SILLGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 180 NIALNWLLIYPVGWGVAGSATGTSLtqwgmAAALGAVMM-----------RGTREHAVRWAPDVAgmRSVLSLGSWLMLR 248
Cdd:cd13147 170 NIILDPIFIYTLGLGIAGAAWATVI-----SMLISSLVLlywffvkkdtyVSLSLKNFKFDKKIV--KDILKVGIPASLE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 249 TLSMRI-ASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLnvesERAKVrqlknrLLRM 327
Cdd:cd13147 243 QLIMSVlMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNY----EKLKT------AYNY 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1317672449 328 SLIYGVITGL-ICPLIGFFGSWIftqdaqvAFLFTiatviialgqpiaayvFTLDGILMGAQDVKYLAIGCFIMLVM 403
Cdd:cd13147 313 SIKLGLIIELiIAILIFIFAPQI-------AYLFT----------------YSEESAHLAPEIVAFLRIMCLFLPFV 366
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-277 |
4.60e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 80.01 E-value: 4.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 20 ILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSiaatLVTTVVGLMNFLAY-----SVTPAVARAFGEKNLRRAW 94
Cdd:cd13148 14 LLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVA----LVFPLLMLTQMMSNgamggGVSSAIARALGAGDRERAE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 95 QIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVAT 174
Cdd:cd13148 90 ALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 175 VGTLVNIALNWLLIYPVG----WGVAGSATGTSLTQWGMAAALGAVMMRGTREHAVRWAP---DVAGMRSVLSLGSWLML 247
Cdd:cd13148 170 VGAVVQIPLSPGLILGWGplprLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLRAlrlERRLFRDILRVGLLAAL 249
|
250 260 270
....*....|....*....|....*....|
gi 1317672449 248 RTLSMRIASLLTVFVVARFGTEHTAAYQLG 277
Cdd:cd13148 250 SPLQTNLTVLLLTGLVGRFGTAALAGYGIG 279
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
18-455 |
1.09e-15 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 79.01 E-value: 1.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIG 97
Cdd:PRK10189 29 REITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 98 ----VDGVWVAFGLGMLLMIAGYAFADplLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVA 173
Cdd:PRK10189 109 rqslVIMTLFAVLLAVLIHFFGEQIID--LVAGDATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLIN 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 174 TVGTLVNIALNWLLIYPV----GWGVAGSATGTSLTQWGMAAALGAVMMRGTREhAVR------WAP-DVAGMRSVLSLG 242
Cdd:PRK10189 187 GGMNILNIIISSILIYGLfswqGLGFVGAGLGLTISRYIGAVAIIWVLMIGFNP-ALRislksyFKPlNFAIIWEVMGIG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 243 SWLMLRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLNveserAKVRQLKN 322
Cdd:PRK10189 266 IPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIA-----QAERQLRH 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 323 RLLRMSLIYGVITGLICPLIGFFGSWiFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKYL-------AI 395
Cdd:PRK10189 341 VFWLSTLGLTAIAWLSAPFAGLLASF-YTQDPDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYAmwvsmlgMW 419
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 396 GCFIMLVMYVPVMLGLhwavgagtmdalaGYCGLWAAYILYFqGIRAVIFGRRARSDVWM 455
Cdd:PRK10189 420 GCRVVAGYILGIMLGF-------------GVVGVWMGMFLDW-AVRGVLFYWRMVSGRWL 465
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
18-204 |
7.20e-11 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 63.88 E-value: 7.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQL-GKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQI 96
Cdd:cd12082 219 RRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 97 GVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVG 176
Cdd:cd12082 299 TWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLS 378
|
170 180
....*....|....*....|....*...
gi 1317672449 177 TLVNIALNWLLIYPVGWGVAGSATGTSL 204
Cdd:cd12082 379 YWVVRLPLAYVLAYLGLGLYGIWLALVI 406
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
18-219 |
3.06e-10 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 62.09 E-value: 3.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNF-LAYSVTPAVARAFGEKNLRRAWQI 96
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVaIGTALLPRLSRAAAAGDLEEFRRT 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 97 GVDGVWVAFGLGMLLMIAGYAFADPLLRGL---GATDET----ISYALDYLhhsLWGIPPMMIILAQVGTLRGLQDTVTP 169
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIVLAEPIVRLLferGAFTAEdtalTALALAAY---ALGLPAFALVKVLARAFYARQDTRTP 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1317672449 170 LKVATVGTLVNIALNWLLIYPvgWGVAGSATGTSLTQWGMAAALGAVMMR 219
Cdd:COG0728 379 VRIAVIAVVVNIVLNLLLVPP--LGHAGLALATSLSALVNALLLLVLLRR 426
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
18-219 |
3.26e-10 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 61.70 E-value: 3.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLmnfLAYSVT----PAVARAFGEKNLRRA 93
Cdd:cd13123 215 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLYQLPLGI---FGVAIAtallPRLSRLAAAGDLDEF 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 94 WQIGVDGVWVAFGLGMLLMIAGYAFADPLLRGL---GATDET----ISYALDYLhhsLWGIPPMMIILAQVGTLRGLQDT 166
Cdd:cd13123 292 RRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLferGAFTAEdtlmTASALAAY---ALGLPAFALVKLLSRAFYALKDT 368
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1317672449 167 VTPLKVATVGTLVNIALNWLLIYPvgWGVAGSATGTSLTQWGMAAALGAVMMR 219
Cdd:cd13123 369 KTPVKIAVIAVAVNILLNLLLIKP--LGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-450 |
6.65e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 60.77 E-value: 6.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 20 ILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVD 99
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 100 GVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLV 179
Cdd:cd13135 83 SIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 180 NIALNWLLIY-PVGW---GVAGSATGTSLtqwgmAAALGAVMM--------------RGTREHAVRWAPDVAGMRsvlsL 241
Cdd:cd13135 163 NVILDYVLIFgNFGFprlGIIGAAIATTI-----ANVLNLIILvylcrkikkltfklSNTKVLKANIRPYKFTIK----L 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 242 GSWLMLRTLSMRIASLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDLnveseRAKVRQLk 321
Cdd:cd13135 234 GLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDL-----KEALRIG- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 322 NRLLRMSLIYGVITGLICPLIGFFGSWIFTQDAQV---AFLFTIATVIIALGQPI-AAYVFTLDGIlmgaQDVKYLAIGC 397
Cdd:cd13135 308 NICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELinySIPYLIFIIIILFFKSInIVYGFAIRAI----GDTKWMLYTQ 383
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1317672449 398 FIMLVMYVPVMLGLHWAVGAGtmdaLAG-YCGLWAAYIlyfqgIRAVIFGRRAR 450
Cdd:cd13135 384 IIGTIIVVSVALLLIFVFKLG----LAGvYITLFIDEI-----IRAIINFLKYR 428
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
20-242 |
2.49e-09 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 58.99 E-value: 2.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 20 ILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVD 99
Cdd:PRK00187 12 ILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGATRLAQA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 100 GVWVAFGLGMLLMIAGYAFAdPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLV 179
Cdd:PRK00187 92 GLWLAWLLALVAALLLWNLK-PLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAGAVA 170
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1317672449 180 NIALNWLLIYpvGW------GVAGSATGTSLTQWGMAAALGAVMMRGTREHAVR-----WAPDVAGMRSVLSLG 242
Cdd:PRK00187 171 NLLLNYALIE--GWfglpklGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPlrkglSRPSRAALRELWRLG 242
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
9-206 |
7.25e-09 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 57.70 E-value: 7.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 9 ANTAEPSLNRRILALAVPAFGALIAEPIFVLTDSALIGQ-LGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGE 87
Cdd:PRK09575 3 TIMMNQSIYRTFWRYTIPSIAAMLVNGLYQIVDGIFIGHyVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 88 KNLRRAWQIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTLR--GLQD 165
Cdd:PRK09575 83 GDLEKAKRILTTGLLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRndESPN 162
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1317672449 166 TVTPLKVatVGTLVNIALNWLLIYPVGWGVAGSATGTSLTQ 206
Cdd:PRK09575 163 LATGLMV--IGALINIVLDYLFIGWLDWGLTGAAIATALAQ 201
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
256-407 |
1.36e-08 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 53.72 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 256 SLLTVFVVARFGTEHTAAYQLGMGVFNLFLYALDSLAIAAQALLGKELGERDlnveseRAKVRQLKNRLLRMSLIYGVIT 335
Cdd:pfam01554 13 SLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGN------FKRAGVALRQGLILGLLLSLPI 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1317672449 336 GLICPLIGFFGSWIFTQDAQVAFLFTIATVIIALGQPIAAYVFTLDGILMGAQDVKYLAIGCFIMLVMYVPV 407
Cdd:pfam01554 87 ALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPL 158
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
13-217 |
6.85e-07 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 51.39 E-value: 6.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 13 EPSLNRRILALAVPAFGALIAEPIFVLTDSALIGQ-LGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGE--KN 89
Cdd:cd13128 201 DLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYfLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKNdkDE 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 90 LRRAWQIGVDGVwvaFGLGMLLMIAGYAFADPLLRGL-GATDETISYALDYLhhsLWGIPPMMIILAQVGTLRGLQDTVT 168
Cdd:cd13128 281 LKKLLKKSFKYL---FLISLPIAIGLFLFAEPIITLLfGEEYLPAALVLQIL---AWGFLFIFLNGIFGSILQAIGKQKL 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1317672449 169 PLKVATVGTLVNIALNWLLIYPvgWGVAGSATGTSLTQWGMAAALGAVM 217
Cdd:cd13128 355 TLKILLIGALLNVILNLLLIPK--YGIIGAAIATLISEFIIFILLLYLL 401
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
18-204 |
1.02e-06 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 50.93 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVP-AFGALIAePIFVLTDSALIGQLgkAELAGMS-------------IAATLVTTVVGLMNFLAYSVTPAVAR 83
Cdd:cd13124 224 KELLSYAIPiTLSSLIL-PLLQLIDSFTVPRR--LQAAGLSeseatalygiltgRAQPLVQLPTVIATALSTSLVPAISE 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 84 AFGEKNLRRAWQIGVDgvwvAFGLGMLLMIAG----YAFADPLLRGLGATDEtisyALDYLHHSLWGIPPMMIILAQVGT 159
Cdd:cd13124 301 AYAKGDKKELRRRINQ----ALRLTLLIGLPAavglAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTAAI 372
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1317672449 160 LRGLQDTVTPLKVATVGTLVNIALNWLLIYpvGWGVAGSATGTSL 204
Cdd:cd13124 373 LQGLGKVKIPVINLLIGLLVKIVLNYVLIP--IFGIYGAAIATVI 415
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
20-213 |
2.70e-06 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 49.18 E-value: 2.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 20 ILALAVPAFGALIAEPIFVLTDSALIGQ-LGKAELAGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGV 98
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGAlLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 99 DGVWVAFGLGMLLMIAGYAFADPLLRGLgaTDETISYALDYLHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTL 178
Cdd:COG2244 255 KALRLLLLLGLPLALGLALLAPPLLSLL--FGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAV 332
|
170 180 190
....*....|....*....|....*....|....*
gi 1317672449 179 VNIALNWLLIYPvgWGVAGSATGTSLTQWGMAAAL 213
Cdd:COG2244 333 LNLVLNLLLIPR--YGLVGAAIATLLSYLVLLLLL 365
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
81-197 |
4.50e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 42.51 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 81 VARAFGEKNLRRAWQIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETISYALDYLHHSLWGIPPMMIILAQVGTL 160
Cdd:cd13140 294 VGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAF 373
|
90 100 110
....*....|....*....|....*....|....*..
gi 1317672449 161 RGLQDTVTPLKVATVGTLVNIALNWLLIYPvGWGVAG 197
Cdd:cd13140 374 NGLGRTKPPAIISIVFNGLRIPLALLLSPT-GLGLNG 409
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
18-213 |
1.23e-03 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 41.12 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 18 RRILALAVPAFGALIAEPIFVLTDSALIGQLGKAELAGMSIAATLVTTVVGLM-NFLAYSVTPAVARAFGEKNLRRAWQI 96
Cdd:pfam03023 197 KRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYADRIYQLPLGIFgVSISTVLLPRLSRHAADGDWDEFRDL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 97 GVDGVWVAFGLGMLLMIAGYAFADPLLRGL---GATDETISYALDY-LHHSLWGIPPMMIILAQVGTLRGLQDTVTPLKV 172
Cdd:pfam03023 277 LDQAIRLTLLLMIPVSFGLLVLSIPIVSLLferGNFSPEDVTATAEvLAAYALGLIPYALVKLLSRVFYAREDTKTPFKI 356
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1317672449 173 ATVGTLVNIALNWLLIYPvgWGVAGSATGTSLTQWGMAAAL 213
Cdd:pfam03023 357 SLISAVLNILLSLLLLPP--LGVAGLALATSLSSLIGLVFL 395
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
54-411 |
7.37e-03 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 38.39 E-value: 7.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 54 AGMSIAATLVTTVVGLMNFLAYSVTPAVARAFGEKNLRRAWQIGVDGVWVAFGLGMLLMIAGYAFADPLLRGLGATDETI 133
Cdd:COG2244 36 EEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRRLLSTALLLRLLLSLLLALLLLLLAPFIAALLGEPELAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 134 SYALdylhhSLWGIPPMMIILAQVGTLRGLQDTVTPLKVATVGTLVNIALNWLLIYpVGWGVAGSatgtsltqwgmaaal 213
Cdd:COG2244 116 LLLL-----LALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLALLLAL-LGLGLWGL--------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 214 gavmmrgtrehavrwapdvagmrsVLSLGSWLMLRTLSMRIASLLTVFVVARF-GTEHTAAYQLGMGVFNLFLYALDSLA 292
Cdd:COG2244 175 ------------------------VLKYSLPLLLSGLLGLLLTNLDRLLLGALlGPAAVGIYSAAYRLASLLLLLITALS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317672449 293 IAAQALLGKELGERDLnveserakvRQLKNRLLRMSLIYGVITGLICPLIGFFGSWIFTQDAQVAFLFTIATV-IIALGQ 371
Cdd:COG2244 231 QVLFPRLSRLLAEGDR---------EELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAEAAPVLpILALGA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1317672449 372 PIAAYVFTLDGILMGAQDVKYLAIGCFIMLVMYVPVMLGL 411
Cdd:COG2244 302 LFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLL 341
|
|
| |
