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Conserved domains on  [gi|1319887422|gb|PLL65515|]
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phosphoheptose isomerase, partial [Klebsiella pneumoniae]

Protein Classification

phosphoheptose isomerase family protein( domain architecture ID 51)

phosphoheptose isomerase family protein may catalyze the isomerization of sedoheptulose 7-phosphate into D-glycero-D-manno-heptose 7-phosphate

CATH:  3.40.50.10490
EC:  5.3.1.28
Gene Ontology:  GO:0008968|GO:0008270|GO:0097367|GO:1901135
PubMed:  10203754

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIS super family cl00389
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 1-65 5.36e-48

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


The actual alignment was detected with superfamily member PRK10886:

Pssm-ID: 444881  Cd Length: 196  Bit Score: 149.70  E-value: 5.36e-48
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLLGQQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD 65
Cdd:PRK10886  132 AVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD 196
 
Name Accession Description Interval E-value
PRK10886 PRK10886
DnaA initiator-associating protein DiaA; Provisional
 1-65 5.36e-48

DnaA initiator-associating protein DiaA; Provisional


Pssm-ID: 182811  Cd Length: 196  Bit Score: 149.70  E-value: 5.36e-48
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLLGQQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD 65
Cdd:PRK10886  132 AVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD 196
GmhA COG0279
Phosphoheptose isomerase [Carbohydrate transport and metabolism];
1-61 1.13e-26

Phosphoheptose isomerase [Carbohydrate transport and metabolism];


Pssm-ID: 440048 [Multi-domain]  Cd Length: 189  Bit Score: 95.18  E-value: 1.13e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLlgqQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFP 61
Cdd:COG0279   132 ARERGMTTIALTGRDGGKLAGL---ADIEIRVPSDSTARIQEVHLLIIHILCELIEAALFG 189
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 1-57 2.97e-19

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 75.62  E-value: 2.97e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLlgqQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDN 57
Cdd:cd05006   124 AKERGMKTIALTGRDGGKLLEL---ADIEIHVPSDDTPRIQEVHLLIGHILCELVEE 177
gmhA TIGR00441
phosphoheptose isomerase; This model describes phosphoheptose isomerase. Because a closely ...
 1-56 1.64e-12

phosphoheptose isomerase; This model describes phosphoheptose isomerase. Because a closely related paralo in Escherichia coli differs in function (DnaA initiator-associating protein diaA), this model has been rebuilt with a high stringency, and is likely to miss many true examples for phosphoheptose isomerase. Involved in lipopolysaccharide biosynthesis it may have a role in virulence in Haemophilus ducreyi. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 129533  Cd Length: 154  Bit Score: 57.95  E-value: 1.64e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLlgqQDVEIRIPSHRSARIQEMHMLTVNCLCDLID 56
Cdd:TIGR00441 102 AKDKGMKTITLAGKDGGKMAGL---ADIELRVPHFYTPRIQEIHIKVIHILCQLIE 154
 
Name Accession Description Interval E-value
PRK10886 PRK10886
DnaA initiator-associating protein DiaA; Provisional
 1-65 5.36e-48

DnaA initiator-associating protein DiaA; Provisional


Pssm-ID: 182811  Cd Length: 196  Bit Score: 149.70  E-value: 5.36e-48
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLLGQQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD 65
Cdd:PRK10886  132 AVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD 196
PRK13936 PRK13936
phosphoheptose isomerase; Provisional
 4-64 5.37e-27

phosphoheptose isomerase; Provisional


Pssm-ID: 237567  Cd Length: 197  Bit Score: 96.27  E-value: 5.37e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1319887422   4 RDMTIVALTGYDGGELAGLLGQQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQD 64
Cdd:PRK13936  137 REMHVVALTGRDGGKMASLLLPEDVEIRVPAERTARIQEVHLLAIHCLCDLIDSQLLGSEE 197
GmhA COG0279
Phosphoheptose isomerase [Carbohydrate transport and metabolism];
1-61 1.13e-26

Phosphoheptose isomerase [Carbohydrate transport and metabolism];


Pssm-ID: 440048 [Multi-domain]  Cd Length: 189  Bit Score: 95.18  E-value: 1.13e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLlgqQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFP 61
Cdd:COG0279   132 ARERGMTTIALTGRDGGKLAGL---ADIEIRVPSDSTARIQEVHLLIIHILCELIEAALFG 189
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 1-57 2.97e-19

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 75.62  E-value: 2.97e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLlgqQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDN 57
Cdd:cd05006   124 AKERGMKTIALTGRDGGKLLEL---ADIEIHVPSDDTPRIQEVHLLIGHILCELVEE 177
PRK13937 PRK13937
phosphoheptose isomerase; Provisional
 1-61 3.56e-15

phosphoheptose isomerase; Provisional


Pssm-ID: 184408 [Multi-domain]  Cd Length: 188  Bit Score: 65.26  E-value: 3.56e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLLgqqDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFP 61
Cdd:PRK13937  129 ARELGMKTIGLTGRDGGKMKELC---DHLLIVPSDDTPRIQEMHITIGHILCDLVERALFE 186
gmhA TIGR00441
phosphoheptose isomerase; This model describes phosphoheptose isomerase. Because a closely ...
 1-56 1.64e-12

phosphoheptose isomerase; This model describes phosphoheptose isomerase. Because a closely related paralo in Escherichia coli differs in function (DnaA initiator-associating protein diaA), this model has been rebuilt with a high stringency, and is likely to miss many true examples for phosphoheptose isomerase. Involved in lipopolysaccharide biosynthesis it may have a role in virulence in Haemophilus ducreyi. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 129533  Cd Length: 154  Bit Score: 57.95  E-value: 1.64e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLlgqQDVEIRIPSHRSARIQEMHMLTVNCLCDLID 56
Cdd:TIGR00441 102 AKDKGMKTITLAGKDGGKMAGL---ADIELRVPHFYTPRIQEIHIKVIHILCQLIE 154
gmhA PRK00414
D-sedoheptulose 7-phosphate isomerase;
1-56 4.24e-12

D-sedoheptulose 7-phosphate isomerase;


Pssm-ID: 179012 [Multi-domain]  Cd Length: 192  Bit Score: 57.44  E-value: 4.24e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1319887422   1 AVTRDMTIVALTGYDGGELAGLlgqQDVEIRIPSHRSA-RIQEMHMLTVNCLCDLID 56
Cdd:PRK00414  134 ARAKGMKVITLTGKDGGKMAGL---ADIEIRVPHFGYAdRIQEIHIKVIHILIQLIE 187
PRK13938 PRK13938
phosphoheptose isomerase; Provisional
 6-63 1.24e-06

phosphoheptose isomerase; Provisional


Pssm-ID: 139997 [Multi-domain]  Cd Length: 196  Bit Score: 43.19  E-value: 1.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1319887422   6 MTIVALTGYDGGELAGLlgqQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLF-PHQ 63
Cdd:PRK13938  141 VTVVAMTGESGGQLAEF---ADFLINVPSRDTGRIQESHIVFIHAISEHVEHALFaPRQ 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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