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Conserved domains on  [gi|1319952606|gb|PLM15344|]
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ATPase [Klebsiella pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CagE_TrbE_VirB super family cl40727
CagE, TrbE, VirB family, component of type IV transporter system; This family includes the ...
114-919 0e+00

CagE, TrbE, VirB family, component of type IV transporter system; This family includes the Helicobacter pylori protein CagE, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system. The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro. Similar type IV transport systems are also found in other bacteria. This family includes the TrbE and VirB proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. homologs of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis.


The actual alignment was detected with superfamily member TIGR00929:

Pssm-ID: 454818 [Multi-domain]  Cd Length: 785  Bit Score: 562.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 114 QRQPVEEFIPYSTHIHPFICKTKRVDYVASWELQGEAFQCQTAEALELLSEQFNKALVSFSGETVTFYVHTIREKYFDRF 193
Cdd:TIGR00929   4 KEYSMSDFIPYAGHYDDHVILTKNGSLMGIIKLEGISFESASDEDLNLLHRELNAALKSIGSGQVALWVHTVRRKIVIDY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 194 -NSVSGNKFADKVMERYYNDMGQTPFYRNRIFFTVCYIPFNrEEKLERKAKGRAYQ--------QKSQDEAIVRMNEIRE 264
Cdd:TIGR00929  84 pDPEFKNGFAAAIDEEWRRKFASSDLYENDLYLTLEYKPDS-IGVLEKFKKSLTKKtreefqdnYRETLESIKALEDIKR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 265 TVEGMLRHYRPVPLGLIEEGKKVYSSLLSFFNYLISGQWQ--KIRVGNIPFYNVLGSSDLYFSSDSGQANQFDRKRFFRC 342
Cdd:TIGR00929 163 NLLELLREYGAELLKEYDKTGHIYSELLEFLAFLVNGNDIpvTPPVIPGYLDSYIPSSEVLFGKDGFVIRSPKDNRFFSV 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 343 IEIKNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALNSAQDDAVSEQVDLDVLRDMITSGDVSVGK 422
Cdd:TIGR00929 243 ISIKEYPEKTEPGILNALLELDCEFILTHSFSFLSKEAALSKLGRKRKRLISKGDRAKSQIAELDEALDELTSGDFVMGE 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 423 WHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNFADMTAFHSVYGGKR 502
Cdd:TIGR00929 323 HHLSLVVYAEDLEKLDAALREARSLLNACGIVAVIETLGLEAAFWSQLPGNFSWNPRKSLITSRNFASLIPFHNFNLGKL 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 503 DRLPWGEAMLMLDTESRDAYYLNLHQSLLEdddfnrqRLGNAKIIGTAGAGKTMLLDMLAYAMQKYRNhatfspaakskr 582
Cdd:TIGR00929 403 RGNPWGPALTLLKTQSGTPFYFNFHVRDAK-------VLGHTLIFGPTGSGKTTLLNFLLAQMQKYGG------------ 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 583 LTTVFFDKDRGAEVAIRALGGEYYRIRAGESSGWNPFALESTRRNRKFVKDLMKLIVTRRGQ-PLSDRQEDDLFQAVDDV 661
Cdd:TIGR00929 464 MTIFAFDKDRGMEIFIRAFGGAYLEIKDGEPFGFNPFQLEDTERNRAFLKEWLAMLVTLDGStDISAEDRNALSSAIDTV 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 662 MDMPLTQRQygITQLLSYLNEPTtveaqeNGLRIRLKQWKQGGEFGWVFDNEADTFDVRnvDNFGIDGTEFLDDADTRAA 741
Cdd:TIGR00929 544 YREGPLIRS--LSDLLNFLPKDY------IDLADRLEPWLKGGDYGWLFDNPTDDLDLS--KITGFDLTELLDNPKVATP 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 742 ISFYLLYRVTSLLDGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAAMEVTETSIW 821
Cdd:TIGR00929 614 VLMYLFHRINEALDGRPFLIIIDEAWQYLGNPVFAAKIRDWLKTLRKANGIVVLATQSINDALGSRIADSILEQCATKIF 693
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 822 MANPDADYDDYVEKAKVDPAHFNIIKTLDPGSRQFLVvksalRRGEVkkfAALVKFDLSAMGDYLKILSAGEPNLEIFDE 901
Cdd:TIGR00929 694 LPNPEADREDYAEGFKLTEREFELLKSTPEESRKFLI-----KQGQS---SVVAELNLGGMDNYLRVLSSDTENVEIIDA 765
                         810
                  ....*....|....*....
gi 1319952606 902 IW-RPGMKPEDWIDRYLER 919
Cdd:TIGR00929 766 LIkEYGDDPDDWLPIFYRA 784
VirB3 COG3702
Type IV secretory pathway, VirB3 component [Intracellular trafficking, secretion, and ...
1-102 3.74e-21

Type IV secretory pathway, VirB3 component [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442916  Cd Length: 97  Bit Score: 88.78  E-value: 3.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606   1 MATVYKALTRPTLLRGVPIAPFMLSVIAIAIIGLIVTKWLWLLI-PALYFLMRRITSRDEHVFSLMWVWWKTLGKkgmvl 79
Cdd:COG3702     2 EDPLFKGLTRPAMFLGVPLVPFVLNVMVSLILFIWTGSLLYLLLaIPLHFVLRLICRRDPRFFRLLLLRLRTRPR----- 76
                          90       100
                  ....*....|....*....|...
gi 1319952606  80 SRNVatRFYKARAVSHTRYDNID 102
Cdd:COG3702    77 TRNR--RFWGGNSYSPLPYRRRR 97
 
Name Accession Description Interval E-value
VirB4_CagE TIGR00929
type IV secretion/conjugal transfer ATPase, VirB4 family; Type IV secretion systems are found ...
114-919 0e+00

type IV secretion/conjugal transfer ATPase, VirB4 family; Type IV secretion systems are found in Gram-negative pathogens. They export proteins, DNA, or complexes in different systems and are related to plasmid conjugation systems. This model represents related ATPases that include VirB4 in Agrobacterium tumefaciens (DNA export) CagE in Helicobacter pylori (protein export) and plasmid TraB (conjugation).


Pssm-ID: 273346 [Multi-domain]  Cd Length: 785  Bit Score: 562.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 114 QRQPVEEFIPYSTHIHPFICKTKRVDYVASWELQGEAFQCQTAEALELLSEQFNKALVSFSGETVTFYVHTIREKYFDRF 193
Cdd:TIGR00929   4 KEYSMSDFIPYAGHYDDHVILTKNGSLMGIIKLEGISFESASDEDLNLLHRELNAALKSIGSGQVALWVHTVRRKIVIDY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 194 -NSVSGNKFADKVMERYYNDMGQTPFYRNRIFFTVCYIPFNrEEKLERKAKGRAYQ--------QKSQDEAIVRMNEIRE 264
Cdd:TIGR00929  84 pDPEFKNGFAAAIDEEWRRKFASSDLYENDLYLTLEYKPDS-IGVLEKFKKSLTKKtreefqdnYRETLESIKALEDIKR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 265 TVEGMLRHYRPVPLGLIEEGKKVYSSLLSFFNYLISGQWQ--KIRVGNIPFYNVLGSSDLYFSSDSGQANQFDRKRFFRC 342
Cdd:TIGR00929 163 NLLELLREYGAELLKEYDKTGHIYSELLEFLAFLVNGNDIpvTPPVIPGYLDSYIPSSEVLFGKDGFVIRSPKDNRFFSV 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 343 IEIKNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALNSAQDDAVSEQVDLDVLRDMITSGDVSVGK 422
Cdd:TIGR00929 243 ISIKEYPEKTEPGILNALLELDCEFILTHSFSFLSKEAALSKLGRKRKRLISKGDRAKSQIAELDEALDELTSGDFVMGE 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 423 WHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNFADMTAFHSVYGGKR 502
Cdd:TIGR00929 323 HHLSLVVYAEDLEKLDAALREARSLLNACGIVAVIETLGLEAAFWSQLPGNFSWNPRKSLITSRNFASLIPFHNFNLGKL 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 503 DRLPWGEAMLMLDTESRDAYYLNLHQSLLEdddfnrqRLGNAKIIGTAGAGKTMLLDMLAYAMQKYRNhatfspaakskr 582
Cdd:TIGR00929 403 RGNPWGPALTLLKTQSGTPFYFNFHVRDAK-------VLGHTLIFGPTGSGKTTLLNFLLAQMQKYGG------------ 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 583 LTTVFFDKDRGAEVAIRALGGEYYRIRAGESSGWNPFALESTRRNRKFVKDLMKLIVTRRGQ-PLSDRQEDDLFQAVDDV 661
Cdd:TIGR00929 464 MTIFAFDKDRGMEIFIRAFGGAYLEIKDGEPFGFNPFQLEDTERNRAFLKEWLAMLVTLDGStDISAEDRNALSSAIDTV 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 662 MDMPLTQRQygITQLLSYLNEPTtveaqeNGLRIRLKQWKQGGEFGWVFDNEADTFDVRnvDNFGIDGTEFLDDADTRAA 741
Cdd:TIGR00929 544 YREGPLIRS--LSDLLNFLPKDY------IDLADRLEPWLKGGDYGWLFDNPTDDLDLS--KITGFDLTELLDNPKVATP 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 742 ISFYLLYRVTSLLDGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAAMEVTETSIW 821
Cdd:TIGR00929 614 VLMYLFHRINEALDGRPFLIIIDEAWQYLGNPVFAAKIRDWLKTLRKANGIVVLATQSINDALGSRIADSILEQCATKIF 693
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 822 MANPDADYDDYVEKAKVDPAHFNIIKTLDPGSRQFLVvksalRRGEVkkfAALVKFDLSAMGDYLKILSAGEPNLEIFDE 901
Cdd:TIGR00929 694 LPNPEADREDYAEGFKLTEREFELLKSTPEESRKFLI-----KQGQS---SVVAELNLGGMDNYLRVLSSDTENVEIIDA 765
                         810
                  ....*....|....*....
gi 1319952606 902 IW-RPGMKPEDWIDRYLER 919
Cdd:TIGR00929 766 LIkEYGDDPDDWLPIFYRA 784
VirB4 COG3451
Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and ...
337-904 1.44e-134

Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442674 [Multi-domain]  Cd Length: 546  Bit Score: 413.96  E-value: 1.44e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 337 KRFFRCIEIKNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALNSAQ--------DDAVSEQVDLDV 408
Cdd:COG3451     7 DRYGRVLSIKGYPSETSPGLLDPLLQLPCEFIVTQSFTPLDKDEALKKLKRKRRRLESKRkseqalvdDDAESQAEDAEE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 409 LRDMITSGDVSVGKWHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNF 488
Cdd:COG3451    87 ALDELQSGGERLGEVHLTLTVFADDLEELEEAVREVESALQSAGFTLVRETLNQEEAFLSSLPGNFDYRLRRRLLTTSNL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 489 ADMTAFHSVYGGKrdrlPWGeaMLMLDTESRDAYYLNLHqslledddfNRQRLGNAKIIGTAGAGKTMLLDMLAYAMQKY 568
Cdd:COG3451   167 AALFPFHSFELGD----PWG--IYLLNTRSGTPVFFDFH---------DGLDNGNTLILGPSGSGKSFLLKLLLLQLLRY 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 569 RNHatfspaakskrltTVFFDKDRGAEVAIRALGGEYYRIRAGESSGWNPFALESTRRNRKFVKDLMKLIVTRRGQPLSD 648
Cdd:COG3451   232 GAR-------------IVIFDPGGSYEILVRALGGTYIDLSPGSPTGLNPFDLEDTEEKRDFLLELLELLLGREGEPLTP 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 649 RQEDDLFQAVDDVMDMPLTQRQYGITQLLSYLNEPTtvEAQEngLRIRLKQWKQGGEFGWVFDNEaDTFDVRNVDNFGID 728
Cdd:COG3451   299 EERAAIDRAVRALYRRADPEERTTLSDLYELLKEQP--EAKD--LAARLEPYTKGGSYGWLFDGP-TNLDLSDARFVVFD 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 729 GTEFLDDADTRAAISFYLLYRVTSLL----DGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVV 804
Cdd:COG3451   374 LTELLDNPELRPPVLLYLLHRIWNRLrknnDGRPTLIVIDEAWLLLDNPAFAEFLEEWLKTLRKYNGAVIFATQSVEDFL 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 805 KNKIARAAMEVTETSIWMANPDADYDDYVEKAKVDPAHFNIIKTLDPGSRQFLvvksaLRRGEVKKFaalvkFDLSAMGD 884
Cdd:COG3451   454 SSPIAEAIIENSATKILLPQPKADIEDYAELLGLSERELELIRSAGRGKRDFL-----IKQGNGSVV-----FRLDLSPE 523
                         570       580
                  ....*....|....*....|
gi 1319952606 885 YLKILSAGEPNLEIFDEIWR 904
Cdd:COG3451   524 ELALLSTKPEEVAILDELRA 543
PRK13898 PRK13898
type IV secretion system ATPase VirB4; Provisional
111-920 3.35e-94

type IV secretion system ATPase VirB4; Provisional


Pssm-ID: 172418  Cd Length: 800  Bit Score: 315.17  E-value: 3.35e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 111 KLNQRQPVEEFIPYSTHIHPFICKTKRVDYVASWELQGEAFQCQTAEALELLSEQFNKALVSFSGETVTFYVHTIREK-- 188
Cdd:PRK13898   13 RSKRERHTSHFIPYKCHWNSSTILTKDNSLLKVIKLSGFAFETADDEDLDIQKNIRNQLLKSMSSGSFGLYFHTIRRRka 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 189 -YFDRFNSVS-GNKFADKVMERYYNDMGQTPFYRNRIFFTVCYIPFNREEKLERKAKGRAYQQKSQDEAIVRMNEIRETV 266
Cdd:PRK13898   93 vFSDDFPTVKvPNDFATYVNVEWRKKHATKQSFFNELYITILRKPDTKGVEILEYFLKKLRQKSNKEAWENDMKEMYENL 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 267 EGM-------LRHYRPVPLGLIEEGKKVYSSLLSFFNYLIS-GQWQK---IRVGNIPFYnvLGSSDLYFSSDSGQANQFD 335
Cdd:PRK13898  173 EEMtnrvvtsLRNYGPRLLGVRQTPSGVFCEILEFLSSIVNcGDSPGpvaLPRGTIDEY--LPTHRLFFGSKTIEAVSHN 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 336 RKRFFRCIEIKNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALNSAQDDAVSEQVDLDVLRDMITS 415
Cdd:PRK13898  251 ESKYAGIISIKEYGPNTSAGMLDGFLQLPYEFIITQSFQFTNRQVAIGKMQLQQNRMIQSGDKAVSQIAEISTALDDATS 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 416 GDVSVGKWHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNFADMTAFH 495
Cdd:PRK13898  331 GDIAFGEHHLTILCIEKNIKALENALSLAEVELSNCGVYPVREKVNLEPAFWAQLPGNFDYIVRKATISTLNMAGFASQH 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 496 SVYGGKRDRLPWGEAMLMLDTESRDAYYLNLHqslLEDddfnrqrLGNAKIIGTAGAGKTMLLDMLAYAMQKyrnhatFS 575
Cdd:PRK13898  411 NYPLGKKFDNHWGEAVTVFDTTSGTPFYFNFH---VRD-------VGHTLIIGPTGAGKTVLMNFLCAQAMK------FS 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 576 PaakskrlTTVFFDKDRGAEVAIRALGGEYYRIRAGESSGWNPFALESTRRNRKFVKDLMKLIVTRRGQPLSDRQEDDLF 655
Cdd:PRK13898  475 P-------RMFFFDKDRGAEIFIRALNGVYTVIEPRLKCNFNPLQLDDTSENRTFLMEWLKVLVTSNGESLTAQDIKRIN 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 656 QAVDDvmDMPLTQRQYGITQLLSYLNEPTtveaqENGLRIRLKQWKQGGEFGWVFDNEADTFDVRNVDNFGIDGTEFLDD 735
Cdd:PRK13898  548 DAVEG--NFKLKKEDRRLSNLVAFLGIDG-----PNTLAGRIAMWHGKGSHAAIFDNEEDLLDFQKARVFGFEMGELLKD 620
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 736 ADTRAAISFYLLYRVTSLLDGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAAMEV 815
Cdd:PRK13898  621 PVSLAPVLLYLFHRISISLDGTPSMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQ 700
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 816 TETSIWMANPDADyDDYVEKAKVDPAHFNIIKTLDPGSRQFLvVKSALRrgevkkfAALVKFDLSAMGDYLKILSAGEPN 895
Cdd:PRK13898  701 TATQIFLPNLKAT-DIYRSVFMLSEREYILIKHTDPTTRFFL-IKQGVS-------AVVARINLDGMDDIISVLSGRAET 771
                         810       820
                  ....*....|....*....|....*.
gi 1319952606 896 LEIFDEIWRP-GMKPEDWIDRYLERA 920
Cdd:PRK13898  772 VLLLDQIREEvGDDPNKWLPIFYEAV 797
CagE_TrbE_VirB pfam03135
CagE, TrbE, VirB family, component of type IV transporter system; This family includes the ...
278-479 2.77e-32

CagE, TrbE, VirB family, component of type IV transporter system; This family includes the Helicobacter pylori protein CagE, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system. The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro. Similar type IV transport systems are also found in other bacteria. This family includes the TrbE and VirB proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. homologs of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis.


Pssm-ID: 367350 [Multi-domain]  Cd Length: 202  Bit Score: 124.38  E-value: 2.77e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 278 LGLIEEGKKVYSSLLSFFNYLISGQWQKIRVGNIPFY-NVLGSSDLYFSSDSGQANQFDRKRFFRCIEIKNLPGNVDVGG 356
Cdd:pfam03135   1 LSEYGKRGVIYSELLEFYNFLINGENHPVRLPRGMYLdEYIGTSRVPFGKDKFIIRTAKDEKYPSIISIKEYPPETRSGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 357 LDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALnSAQDDAVSEQVDLDVLRDMITSGDVSVGKWHYSFVLYADSLDQ 436
Cdd:pfam03135  81 LDKFLDLDEELIITQSFSFKNKQKALSFLKFTSRKL-SISDDAKSQIMELEDAIDEVRSGDFALGLYHNSLVLFAEDKEK 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1319952606 437 LVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPR 479
Cdd:pfam03135 160 LDASVSEATSLLNAKGFVAVIETIGMEPAFFSQLPGNIRLNFR 202
VirB3 COG3702
Type IV secretory pathway, VirB3 component [Intracellular trafficking, secretion, and ...
1-102 3.74e-21

Type IV secretory pathway, VirB3 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442916  Cd Length: 97  Bit Score: 88.78  E-value: 3.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606   1 MATVYKALTRPTLLRGVPIAPFMLSVIAIAIIGLIVTKWLWLLI-PALYFLMRRITSRDEHVFSLMWVWWKTLGKkgmvl 79
Cdd:COG3702     2 EDPLFKGLTRPAMFLGVPLVPFVLNVMVSLILFIWTGSLLYLLLaIPLHFVLRLICRRDPRFFRLLLLRLRTRPR----- 76
                          90       100
                  ....*....|....*....|...
gi 1319952606  80 SRNVatRFYKARAVSHTRYDNID 102
Cdd:COG3702    77 TRNR--RFWGGNSYSPLPYRRRR 97
VirB3 pfam05101
Type IV secretory pathway, VirB3-like protein; This family includes the Type IV secretory ...
3-74 1.75e-15

Type IV secretory pathway, VirB3-like protein; This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes. The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins.


Pssm-ID: 428303  Cd Length: 82  Bit Score: 72.27  E-value: 1.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1319952606   3 TVYKALTRPTLLRGVPIAPFMLSVIAIAIIGLIVTK-WLWLLIPALYFLMRRITSRDEHVFSLMWVWWKTLGK 74
Cdd:pfam05101   2 PLFKALTRPAMFLGVPLELFLLNGMVSVILFLVGLSlWYLLLAPPLHLVLRLIAKRDPRMFRVLLLWLQTRPR 74
PRK13854 PRK13854
type IV secretion system protein VirB3; Provisional
2-74 1.02e-05

type IV secretion system protein VirB3; Provisional


Pssm-ID: 139914  Cd Length: 108  Bit Score: 45.20  E-value: 1.02e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1319952606   2 ATVYKALTRPTLLRGVPIApfmLSVIAIAIIGLIVTK-----WLWLLIPaLYFLMRRITSRDEHVFSLMWVWWKTLGK 74
Cdd:PRK13854    8 ATLYLAATRPALFLGVPLT---LAGVFMMLAGFVIVIvqnplYEVVLLP-LWFGARLVVERDYNAASVVLLFLRTAGR 81
 
Name Accession Description Interval E-value
VirB4_CagE TIGR00929
type IV secretion/conjugal transfer ATPase, VirB4 family; Type IV secretion systems are found ...
114-919 0e+00

type IV secretion/conjugal transfer ATPase, VirB4 family; Type IV secretion systems are found in Gram-negative pathogens. They export proteins, DNA, or complexes in different systems and are related to plasmid conjugation systems. This model represents related ATPases that include VirB4 in Agrobacterium tumefaciens (DNA export) CagE in Helicobacter pylori (protein export) and plasmid TraB (conjugation).


Pssm-ID: 273346 [Multi-domain]  Cd Length: 785  Bit Score: 562.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 114 QRQPVEEFIPYSTHIHPFICKTKRVDYVASWELQGEAFQCQTAEALELLSEQFNKALVSFSGETVTFYVHTIREKYFDRF 193
Cdd:TIGR00929   4 KEYSMSDFIPYAGHYDDHVILTKNGSLMGIIKLEGISFESASDEDLNLLHRELNAALKSIGSGQVALWVHTVRRKIVIDY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 194 -NSVSGNKFADKVMERYYNDMGQTPFYRNRIFFTVCYIPFNrEEKLERKAKGRAYQ--------QKSQDEAIVRMNEIRE 264
Cdd:TIGR00929  84 pDPEFKNGFAAAIDEEWRRKFASSDLYENDLYLTLEYKPDS-IGVLEKFKKSLTKKtreefqdnYRETLESIKALEDIKR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 265 TVEGMLRHYRPVPLGLIEEGKKVYSSLLSFFNYLISGQWQ--KIRVGNIPFYNVLGSSDLYFSSDSGQANQFDRKRFFRC 342
Cdd:TIGR00929 163 NLLELLREYGAELLKEYDKTGHIYSELLEFLAFLVNGNDIpvTPPVIPGYLDSYIPSSEVLFGKDGFVIRSPKDNRFFSV 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 343 IEIKNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALNSAQDDAVSEQVDLDVLRDMITSGDVSVGK 422
Cdd:TIGR00929 243 ISIKEYPEKTEPGILNALLELDCEFILTHSFSFLSKEAALSKLGRKRKRLISKGDRAKSQIAELDEALDELTSGDFVMGE 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 423 WHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNFADMTAFHSVYGGKR 502
Cdd:TIGR00929 323 HHLSLVVYAEDLEKLDAALREARSLLNACGIVAVIETLGLEAAFWSQLPGNFSWNPRKSLITSRNFASLIPFHNFNLGKL 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 503 DRLPWGEAMLMLDTESRDAYYLNLHQSLLEdddfnrqRLGNAKIIGTAGAGKTMLLDMLAYAMQKYRNhatfspaakskr 582
Cdd:TIGR00929 403 RGNPWGPALTLLKTQSGTPFYFNFHVRDAK-------VLGHTLIFGPTGSGKTTLLNFLLAQMQKYGG------------ 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 583 LTTVFFDKDRGAEVAIRALGGEYYRIRAGESSGWNPFALESTRRNRKFVKDLMKLIVTRRGQ-PLSDRQEDDLFQAVDDV 661
Cdd:TIGR00929 464 MTIFAFDKDRGMEIFIRAFGGAYLEIKDGEPFGFNPFQLEDTERNRAFLKEWLAMLVTLDGStDISAEDRNALSSAIDTV 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 662 MDMPLTQRQygITQLLSYLNEPTtveaqeNGLRIRLKQWKQGGEFGWVFDNEADTFDVRnvDNFGIDGTEFLDDADTRAA 741
Cdd:TIGR00929 544 YREGPLIRS--LSDLLNFLPKDY------IDLADRLEPWLKGGDYGWLFDNPTDDLDLS--KITGFDLTELLDNPKVATP 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 742 ISFYLLYRVTSLLDGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAAMEVTETSIW 821
Cdd:TIGR00929 614 VLMYLFHRINEALDGRPFLIIIDEAWQYLGNPVFAAKIRDWLKTLRKANGIVVLATQSINDALGSRIADSILEQCATKIF 693
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 822 MANPDADYDDYVEKAKVDPAHFNIIKTLDPGSRQFLVvksalRRGEVkkfAALVKFDLSAMGDYLKILSAGEPNLEIFDE 901
Cdd:TIGR00929 694 LPNPEADREDYAEGFKLTEREFELLKSTPEESRKFLI-----KQGQS---SVVAELNLGGMDNYLRVLSSDTENVEIIDA 765
                         810
                  ....*....|....*....
gi 1319952606 902 IW-RPGMKPEDWIDRYLER 919
Cdd:TIGR00929 766 LIkEYGDDPDDWLPIFYRA 784
VirB4 COG3451
Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and ...
337-904 1.44e-134

Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442674 [Multi-domain]  Cd Length: 546  Bit Score: 413.96  E-value: 1.44e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 337 KRFFRCIEIKNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALNSAQ--------DDAVSEQVDLDV 408
Cdd:COG3451     7 DRYGRVLSIKGYPSETSPGLLDPLLQLPCEFIVTQSFTPLDKDEALKKLKRKRRRLESKRkseqalvdDDAESQAEDAEE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 409 LRDMITSGDVSVGKWHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNF 488
Cdd:COG3451    87 ALDELQSGGERLGEVHLTLTVFADDLEELEEAVREVESALQSAGFTLVRETLNQEEAFLSSLPGNFDYRLRRRLLTTSNL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 489 ADMTAFHSVYGGKrdrlPWGeaMLMLDTESRDAYYLNLHqslledddfNRQRLGNAKIIGTAGAGKTMLLDMLAYAMQKY 568
Cdd:COG3451   167 AALFPFHSFELGD----PWG--IYLLNTRSGTPVFFDFH---------DGLDNGNTLILGPSGSGKSFLLKLLLLQLLRY 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 569 RNHatfspaakskrltTVFFDKDRGAEVAIRALGGEYYRIRAGESSGWNPFALESTRRNRKFVKDLMKLIVTRRGQPLSD 648
Cdd:COG3451   232 GAR-------------IVIFDPGGSYEILVRALGGTYIDLSPGSPTGLNPFDLEDTEEKRDFLLELLELLLGREGEPLTP 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 649 RQEDDLFQAVDDVMDMPLTQRQYGITQLLSYLNEPTtvEAQEngLRIRLKQWKQGGEFGWVFDNEaDTFDVRNVDNFGID 728
Cdd:COG3451   299 EERAAIDRAVRALYRRADPEERTTLSDLYELLKEQP--EAKD--LAARLEPYTKGGSYGWLFDGP-TNLDLSDARFVVFD 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 729 GTEFLDDADTRAAISFYLLYRVTSLL----DGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVV 804
Cdd:COG3451   374 LTELLDNPELRPPVLLYLLHRIWNRLrknnDGRPTLIVIDEAWLLLDNPAFAEFLEEWLKTLRKYNGAVIFATQSVEDFL 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 805 KNKIARAAMEVTETSIWMANPDADYDDYVEKAKVDPAHFNIIKTLDPGSRQFLvvksaLRRGEVKKFaalvkFDLSAMGD 884
Cdd:COG3451   454 SSPIAEAIIENSATKILLPQPKADIEDYAELLGLSERELELIRSAGRGKRDFL-----IKQGNGSVV-----FRLDLSPE 523
                         570       580
                  ....*....|....*....|
gi 1319952606 885 YLKILSAGEPNLEIFDEIWR 904
Cdd:COG3451   524 ELALLSTKPEEVAILDELRA 543
PRK13898 PRK13898
type IV secretion system ATPase VirB4; Provisional
111-920 3.35e-94

type IV secretion system ATPase VirB4; Provisional


Pssm-ID: 172418  Cd Length: 800  Bit Score: 315.17  E-value: 3.35e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 111 KLNQRQPVEEFIPYSTHIHPFICKTKRVDYVASWELQGEAFQCQTAEALELLSEQFNKALVSFSGETVTFYVHTIREK-- 188
Cdd:PRK13898   13 RSKRERHTSHFIPYKCHWNSSTILTKDNSLLKVIKLSGFAFETADDEDLDIQKNIRNQLLKSMSSGSFGLYFHTIRRRka 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 189 -YFDRFNSVS-GNKFADKVMERYYNDMGQTPFYRNRIFFTVCYIPFNREEKLERKAKGRAYQQKSQDEAIVRMNEIRETV 266
Cdd:PRK13898   93 vFSDDFPTVKvPNDFATYVNVEWRKKHATKQSFFNELYITILRKPDTKGVEILEYFLKKLRQKSNKEAWENDMKEMYENL 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 267 EGM-------LRHYRPVPLGLIEEGKKVYSSLLSFFNYLIS-GQWQK---IRVGNIPFYnvLGSSDLYFSSDSGQANQFD 335
Cdd:PRK13898  173 EEMtnrvvtsLRNYGPRLLGVRQTPSGVFCEILEFLSSIVNcGDSPGpvaLPRGTIDEY--LPTHRLFFGSKTIEAVSHN 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 336 RKRFFRCIEIKNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALNSAQDDAVSEQVDLDVLRDMITS 415
Cdd:PRK13898  251 ESKYAGIISIKEYGPNTSAGMLDGFLQLPYEFIITQSFQFTNRQVAIGKMQLQQNRMIQSGDKAVSQIAEISTALDDATS 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 416 GDVSVGKWHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNFADMTAFH 495
Cdd:PRK13898  331 GDIAFGEHHLTILCIEKNIKALENALSLAEVELSNCGVYPVREKVNLEPAFWAQLPGNFDYIVRKATISTLNMAGFASQH 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 496 SVYGGKRDRLPWGEAMLMLDTESRDAYYLNLHqslLEDddfnrqrLGNAKIIGTAGAGKTMLLDMLAYAMQKyrnhatFS 575
Cdd:PRK13898  411 NYPLGKKFDNHWGEAVTVFDTTSGTPFYFNFH---VRD-------VGHTLIIGPTGAGKTVLMNFLCAQAMK------FS 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 576 PaakskrlTTVFFDKDRGAEVAIRALGGEYYRIRAGESSGWNPFALESTRRNRKFVKDLMKLIVTRRGQPLSDRQEDDLF 655
Cdd:PRK13898  475 P-------RMFFFDKDRGAEIFIRALNGVYTVIEPRLKCNFNPLQLDDTSENRTFLMEWLKVLVTSNGESLTAQDIKRIN 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 656 QAVDDvmDMPLTQRQYGITQLLSYLNEPTtveaqENGLRIRLKQWKQGGEFGWVFDNEADTFDVRNVDNFGIDGTEFLDD 735
Cdd:PRK13898  548 DAVEG--NFKLKKEDRRLSNLVAFLGIDG-----PNTLAGRIAMWHGKGSHAAIFDNEEDLLDFQKARVFGFEMGELLKD 620
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 736 ADTRAAISFYLLYRVTSLLDGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAAMEV 815
Cdd:PRK13898  621 PVSLAPVLLYLFHRISISLDGTPSMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQ 700
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 816 TETSIWMANPDADyDDYVEKAKVDPAHFNIIKTLDPGSRQFLvVKSALRrgevkkfAALVKFDLSAMGDYLKILSAGEPN 895
Cdd:PRK13898  701 TATQIFLPNLKAT-DIYRSVFMLSEREYILIKHTDPTTRFFL-IKQGVS-------AVVARINLDGMDDIISVLSGRAET 771
                         810       820
                  ....*....|....*....|....*.
gi 1319952606 896 LEIFDEIWRP-GMKPEDWIDRYLERA 920
Cdd:PRK13898  772 VLLLDQIREEvGDDPNKWLPIFYEAV 797
PRK13853 PRK13853
type IV secretion system protein VirB4; Provisional
119-919 2.50e-80

type IV secretion system protein VirB4; Provisional


Pssm-ID: 139913 [Multi-domain]  Cd Length: 789  Bit Score: 276.74  E-value: 2.50e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 119 EEFIPYSTHIHPFICKTKRVDYVASWELQGEAFQCQTAEALELLSEQFNKALVSFSGETVTFYVHTIREkyfdrfNSVSG 198
Cdd:PRK13853   13 EIYLPYVGHLSDHIVLLEDGSIMTMAHISGLPFELEEVEMRNARCRAFNTLLRNIADDNVSIYAHLVRH------NDVPP 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 199 -------NKFADKVMERYYNDMGQTPFYRNRIFFTVCYIPFNREEKLERKAKGRaYQQKSQD--EAIVRMNEIRETVEGM 269
Cdd:PRK13853   87 pparhfrSAFAASLSEAFEERVLSGKLLRNDHFLTLIVSPRTALGKVKRRFTKR-YGKKENDlaGQIRNLEDLWHVVAGA 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 270 LRHYRPVPLGLIEEGKKVYSSLLSFFNYLISGQWQKIRVGNIPfynvLGSS---DLYFSSDSGQANQFDRKRFFRCI-EI 345
Cdd:PRK13853  166 LDAYGLRRLGIREKQQVLFTEIGEALRLIMTGRFTPVPVVSGS----LGASiytDRVICGKRGLEIRTPKDSYVGSIfSF 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 346 KNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALNSAQDDAVSEQVDLDVLRDMITSGDVSVGKWHY 425
Cdd:PRK13853  242 REYPAKTRPGMLNTLLSLDFPLVLTQSFSFLTRAQAHAKLSLKSSQMTSSGDKAVTQISELAEAEDALASNEFVMGSHHL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 426 SFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNFADMTAFHSVYGGKRDRl 505
Cdd:PRK13853  322 SLCVYADDLNSLADRGARARTRLADAGAVVVQEGIGMEAAYWSQLPGNHKWRTRPGAITSRNFAGLVSFENFPEGARSG- 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 506 PWGEAMLMLDTESRDAYYLNLHqsllEDDdfnrqrLGNAKIIGTAGAGKTMLLD-MLAYAMQKYRNHATfspaakskrlT 584
Cdd:PRK13853  401 HWGNAIARFRTNGGTPFDYIPH----EHD------VGMTAIFGPIGRGKTTLMTfILAMLEQSMVDRAG----------A 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 585 TVFFDKDRGAEVAIRALGGEYYRIRAGESSGWNPF-ALESTRRNRKFVKDLMKLIVTRRGQ-PLSDRQEDDLFQAVDDVM 662
Cdd:PRK13853  461 VVFFDKDRGGELLVRATGGTYLALRRGVPSGLAPLrGLENTAASRDFLREWIVALIESDGRgGISPEENRRLVRGIQRQL 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 663 DM-PLTQRQYGITQLLsyLNEPTtveaqeNGLRIRLKQWKQGGEFGWVFDNEADtfDVR-NVDNFGIDGTEFLDDADTRA 740
Cdd:PRK13853  541 SFdPNMRSLAGLREFL--LHGPA------EGAGARLQRWCRGNALGWAFDGEVD--EVKlDPSITGFDMTHLLEYEEVCA 610
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 741 AISFYLLYRVTSLLDGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAAMEVTETSI 820
Cdd:PRK13853  611 PAAAYLLHRIGAMVDGRRFVMSCDEFRAYLLNPKFAAVVDKFLLTVRKNNGMLILATQQPEHVLESPLGASLVAQCMTKI 690
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 821 WMANPDADYDDYVEKAKVDPAHFNIIKT-LDPGSRQFLvvksaLRRgevKKFAALVKFDLSAMGDYLKILSaGEPNLEIF 899
Cdd:PRK13853  691 FYPSPTADRSAYIDGLKCTEKEFQAIREdMAVGSRKFL-----LKR---ESGSVICEFDLRDMREYVAVLS-GRANTVRF 761
                         810       820
                  ....*....|....*....|..
gi 1319952606 900 DEIWRP--GMKPEDWIDRYLER 919
Cdd:PRK13853  762 ADQLREthGDDPSAWLSEFMAR 783
CagE_TrbE_VirB pfam03135
CagE, TrbE, VirB family, component of type IV transporter system; This family includes the ...
278-479 2.77e-32

CagE, TrbE, VirB family, component of type IV transporter system; This family includes the Helicobacter pylori protein CagE, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system. The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro. Similar type IV transport systems are also found in other bacteria. This family includes the TrbE and VirB proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. homologs of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis.


Pssm-ID: 367350 [Multi-domain]  Cd Length: 202  Bit Score: 124.38  E-value: 2.77e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 278 LGLIEEGKKVYSSLLSFFNYLISGQWQKIRVGNIPFY-NVLGSSDLYFSSDSGQANQFDRKRFFRCIEIKNLPGNVDVGG 356
Cdd:pfam03135   1 LSEYGKRGVIYSELLEFYNFLINGENHPVRLPRGMYLdEYIGTSRVPFGKDKFIIRTAKDEKYPSIISIKEYPPETRSGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 357 LDALLFEQAEYVTTQSFTCMSKTEALETIKSKGKALnSAQDDAVSEQVDLDVLRDMITSGDVSVGKWHYSFVLYADSLDQ 436
Cdd:pfam03135  81 LDKFLDLDEELIITQSFSFKNKQKALSFLKFTSRKL-SISDDAKSQIMELEDAIDEVRSGDFALGLYHNSLVLFAEDKEK 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1319952606 437 LVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPR 479
Cdd:pfam03135 160 LDASVSEATSLLNAKGFVAVIETIGMEPAFFSQLPGNIRLNFR 202
PRK13891 PRK13891
conjugal transfer protein TrbE; Provisional
140-865 6.34e-30

conjugal transfer protein TrbE; Provisional


Pssm-ID: 184375 [Multi-domain]  Cd Length: 852  Bit Score: 127.56  E-value: 6.34e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 140 YVASWELQGEAFQCQTAEALELLSEQFNKALVSF-SGETVtfYVHTIRE---KYFDRfnsvSGNKFADKVME-------R 208
Cdd:PRK13891   65 FMAAWLYKGDDNASSTDEQREMVSFRINQALAGLgSGWMV--HVDAVRRpapNYSER----GVSHFPDPVSAaideerrR 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 209 YYNDMGQtpFYRNRIFFTVCYIP------------FNRE-EKLERKAKGRAYQQKSQDEAIVRMNEIRETVEGM-LRHYR 274
Cdd:PRK13891  139 LFEGLGT--MYEGYFVLTLTWFPpvlaqrkfvelmFDDDaVAPDHKARTHGLIEQFKREITSLESRLSSAVKLTrLRGQK 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 275 PVplglIEEGKKV-YSSLLSFFNYLISGQWQKIRVGNIPFY--NVLGSSDLYfssdSGQANQFDRKrFFRCIEIKNLPGN 351
Cdd:PRK13891  217 VV----NEDGREVtHDDFLSWLQFCVTGLNHPVMLPSNPMYldALIGGQELW----GGVVPKIGRK-FIQVVAIEGFPLE 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 352 VDVGGLDALLFEQAEYVTTQSFTCMSKTEA---LETIKSKGKA-------------LNSAQDDAVSEQVDLDVLRDMITS 415
Cdd:PRK13891  288 SYPGILSALAELPIEYRWSSRFIFMDQHEAvkhLDKFRKKWKQkirgffdqvfntnTGSIDQDALSMVGDAEAAIAEVNS 367
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 416 GDVSVGKWHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAFFAQLPGNYNLRPRCVPISSQNFADMTAFH 495
Cdd:PRK13891  368 GLVAQGYYTSVVVLMDEDRERLEASALLVEKAINRLGFAARIETINTMDAYLGSLPGHGVENVRRPLINTMNLADLLPTS 447
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 496 SVYGGKRDR-----LPWGEAMLMLDTESRDAYYLNLHqslLEDddfnrqrLGNAKIIGTAGAGKTMLLDMLAYAMQKYRN 570
Cdd:PRK13891  448 SIWTGSATApcpmyPPLSPALMHCVTVGATPFRLNLH---VRD-------LGHTFMFGPTGAGKSTHLGIIAAQLRRYAG 517
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 571 HATFSpaakskrlttvfFDKDR-------GAEVAIRALGGEYYRIRAGESS-GWNPFALESTRRNRKFVKDLMKLIVTRR 642
Cdd:PRK13891  518 MSIYA------------FDKGMsmyplaaGIRAATKGKSGLHFTVAADDDRlAFCPLQFLETKGDRAWAMEWIDTILALN 585
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 643 GQPLSDRQEDDLFQAVddvMDMPLTQrqygiTQLLSYLneptTVEAQENGLRIRLKQWKQGGEFGWVFDNEADTFDVRNV 722
Cdd:PRK13891  586 GVNTTPAQRNEIGNAI---MSMHASG-----ARTLSEF----SVTIQDEAIREAIKQYTVDGSMGHLLDAEEDGLSLSDF 653
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 723 DNFGIDgtEFLDDADTRA-AISFYLLYRVTSLLDGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLD 801
Cdd:PRK13891  654 TVFEIE--ELMNLGEKFAlPVLLYLFRRIERALKGQPAVIILDEAWLMLGHPAFRAKIREWLKVLRKANCLVLMATQSLS 731
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1319952606 802 EVVKNKIARAAMEVTETSIWMANP---DADYDDYVEKAKVDPAHFNIIKTLDPgSRQFLVVKSALRR 865
Cdd:PRK13891  732 DAANSGILDVIVESTATKIFLPNVyarDEDTSALYRRMGLNARQIEILATAIP-KRQYYYVSENGRR 797
PRK13873 PRK13873
conjugal transfer ATPase TrbE; Provisional
465-827 2.71e-29

conjugal transfer ATPase TrbE; Provisional


Pssm-ID: 237536 [Multi-domain]  Cd Length: 811  Bit Score: 125.41  E-value: 2.71e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 465 AFFAQLPGN-Y-NLR-PrcvPISSQNFADMTAFHSVYGG-KRDRLPWGEAMLMLDTESRDAYYLNLHQsllEDddfnrqr 540
Cdd:PRK13873  374 AWLGSLPGHvYaNVRqP---PVSTLNLAHMMPLSAVWAGpERNEHLDAPPLLYARTEGSTPFRLSLHV---GD------- 440
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 541 LGNAKIIGTAGAGKTMLLDMLAYAMQKYRNHATFspaakskrlttvFFDKDRGAEVAIRALGGEYYRIRAGESSgwnPFA 620
Cdd:PRK13873  441 VGHTLVVGPTGAGKSVLLALMALQFRRYPGAQVF------------AFDFGGSIRAATLAMGGDWHDLGGGADG---SVA 505
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 621 LESTRR-----NRKFVKDLMKLIVTRRGQPLSDRQEDDLFQAVDDVMDMPLTQRQygITQLlsylneptTVEAQENGLRI 695
Cdd:PRK13873  506 LQPLARiddeaERAWAAEWIAGILAREGVAVTPEVKEHIWSALTSLASAPVEERT--LTGL--------SVLLQSNALKQ 575
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 696 RLKQWKQGGEFGWVFDNEADTFDVRNVDNFGIDGTeflddADTRAAIS---FYLLYRVTSLLDGRRLVIIMDEFWKWLTS 772
Cdd:PRK13873  576 ALAPYCLGGPHGRLLDADAERLGSADVQAFEMEGL-----MGTKAAAPavlSYLFHRIEDRFDGRPTLLILDEAWLFLDD 650
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1319952606 773 DAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAAMEVTETSIWMANPDA 827
Cdd:PRK13873  651 PVFAAQLREWLKTLRKKNVSVIFATQSLADIDGSAIAPAIIESCPTRIFLPNERA 705
PRK13830 PRK13830
conjugal transfer protein TrbE; Provisional
245-865 5.10e-27

conjugal transfer protein TrbE; Provisional


Pssm-ID: 237525 [Multi-domain]  Cd Length: 818  Bit Score: 118.41  E-value: 5.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 245 RAYQQKSQDEAIVRMNEIRETVE-GMLRHYRpvplglieegkkvYSSLLSFFNYLISGQWQKIRVGNIPFY-NVLGSSDL 322
Cdd:PRK13830  166 REVEQYLANVVSIRRMETRETVErGGFRVAR-------------YDELFQFIRFCITGENHPVRLPDIPMYlDWLVTAEL 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 323 yfssDSGQANQFDrKRFFRCIEIKNLPGNVDVGGLDALLFEQAEYVTTQSFTCMSKTEA---LETIKSKGKALNSAQDDA 399
Cdd:PRK13830  233 ----QHGLTPKVE-NRFLGVVAIDGLPAESWPGILNSLDLMPLTYRWSSRFIFLDAEEArqkLERTRKKWQQKVRPFFDQ 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 400 V----SEQVDLDVL------RDMI---TSGDVSVGKWHYSFVLYADSLDQLVRDSNDIRATLTDLGMIVTLAQIALPAAF 466
Cdd:PRK13830  308 LfqtqSRSVDQDAMmmvaetEDAIaqaSSQLVAYGYYTPVIVLFDEDQERLQEKAEAIRRLIQAEGFGARIETLNATDAF 387
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 467 FAQLPGNYNLRPRCVPISSQNFADMTAFHSVYGGKRDR----LPWGEAMLMLDTESRDAYYLNLHQslledDDfnrqrLG 542
Cdd:PRK13830  388 LGSLPGNWYANIREPLINTRNLADLIPLNSVWSGSPVApcpfYPPNSPPLMQVASGSTPFRLNLHV-----DD-----VG 457
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 543 NAKIIGTAGAGKTMLLDMLAYAMQKYRNHATFSpaakskrlttvfFDKDRGAEVAIRALGGEYYRIRAGESSGWN----- 617
Cdd:PRK13830  458 HTLIFGPTGSGKSTLLALIAAQFRRYAGAQIFA------------FDKGRSMLPLTLAAGGDHYEIGGDAAEEGEglafc 525
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 618 PFALESTRRNRKFVKDLMKLIVTRRGQPLSDrqedDLFQAVDDVMDMPLTQRQYGITQLLSylneptTVEAQEngLRIRL 697
Cdd:PRK13830  526 PLAELSTDGDRAWAAEWIETLVALQGVTITP----DHRNAISRQIGLMAEARGRSLSDFVS------GVQMRE--IKDAL 593
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 698 KQWKQGGEFGWVFDNEADTFDVRNVDNFGIdgtEFLDDADTR--AAISFYLLYRVTSLLDGRRLVIIMDEFWKWLTSDAF 775
Cdd:PRK13830  594 HHYTVDGPMGQLLDAEEDGLALGAFQTFEI---EELMNMGERnlVPVLTYLFRRIEKRLTGAPSLIILDEAWLMLGHPVF 670
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 776 TDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAAMEVTETSIWMANPDA---DYDDYVEKAKVDPAHFNIIKTLDPg 852
Cdd:PRK13830  671 RDKIREWLKVLRKANCAVVLATQSISDAERSGIIDVLKESCPTKICLPNGAArepGTREFYERIGFNERQIEIVATAIP- 749
                         650
                  ....*....|...
gi 1319952606 853 SRQFLVVKSALRR 865
Cdd:PRK13830  750 KREYYVASPEGRR 762
VirB3 COG3702
Type IV secretory pathway, VirB3 component [Intracellular trafficking, secretion, and ...
1-102 3.74e-21

Type IV secretory pathway, VirB3 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442916  Cd Length: 97  Bit Score: 88.78  E-value: 3.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606   1 MATVYKALTRPTLLRGVPIAPFMLSVIAIAIIGLIVTKWLWLLI-PALYFLMRRITSRDEHVFSLMWVWWKTLGKkgmvl 79
Cdd:COG3702     2 EDPLFKGLTRPAMFLGVPLVPFVLNVMVSLILFIWTGSLLYLLLaIPLHFVLRLICRRDPRFFRLLLLRLRTRPR----- 76
                          90       100
                  ....*....|....*....|...
gi 1319952606  80 SRNVatRFYKARAVSHTRYDNID 102
Cdd:COG3702    77 TRNR--RFWGGNSYSPLPYRRRR 97
VirB3 pfam05101
Type IV secretory pathway, VirB3-like protein; This family includes the Type IV secretory ...
3-74 1.75e-15

Type IV secretory pathway, VirB3-like protein; This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes. The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins.


Pssm-ID: 428303  Cd Length: 82  Bit Score: 72.27  E-value: 1.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1319952606   3 TVYKALTRPTLLRGVPIAPFMLSVIAIAIIGLIVTK-WLWLLIPALYFLMRRITSRDEHVFSLMWVWWKTLGK 74
Cdd:pfam05101   2 PLFKALTRPAMFLGVPLELFLLNGMVSVILFLVGLSlWYLLLAPPLHLVLRLIAKRDPRMFRVLLLWLQTRPR 74
PRK13854 PRK13854
type IV secretion system protein VirB3; Provisional
2-74 1.02e-05

type IV secretion system protein VirB3; Provisional


Pssm-ID: 139914  Cd Length: 108  Bit Score: 45.20  E-value: 1.02e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1319952606   2 ATVYKALTRPTLLRGVPIApfmLSVIAIAIIGLIVTK-----WLWLLIPaLYFLMRRITSRDEHVFSLMWVWWKTLGK 74
Cdd:PRK13854    8 ATLYLAATRPALFLGVPLT---LAGVFMMLAGFVIVIvqnplYEVVLLP-LWFGARLVVERDYNAASVVLLFLRTAGR 81
HerA COG0433
Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase ...
546-879 3.01e-05

Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase domains [Replication, recombination and repair];


Pssm-ID: 440202 [Multi-domain]  Cd Length: 388  Bit Score: 47.29  E-value: 3.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 546 IIGTAGAGKTMLLDMLAYAMQKyrnhatfspaaksKRLTTVFFD------KDRGAEVAIRALGgeYYRIRAGESSGWNPF 619
Cdd:COG0433    52 ILGATGSGKSNTLQVLLEELSR-------------AGVPVLVFDphgeysGLAEPGAERADVG--VFDPGAGRPLPINPW 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 620 ALESTrrnrkfVKDLMKLIVTRRgqPLSDRQEDDLFQAVDDVMDMPLtqRQYGITQLLSYLNEPTTVEAQENG------- 692
Cdd:COG0433   117 DLFAT------ASELGPLLLSRL--DLNDTQRGVLREALRLADDKGL--LLLDLKDLIALLEEGEELGEEYGNvsaasag 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 693 -LRIRLKQWKQGGEFgwvFDNEADTFDvrnvDNFGIDG------TEFLDDaDTRAAISFYLLYRVTSLL--------DGR 757
Cdd:COG0433   187 aLLRRLESLESADGL---FGEPGLDLE----DLLRTDGrvtvidLSGLPE-ELQSTFVLWLLRELFEARpevgdaddRKL 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 758 RLVIIMDEFWKWL--TSDAFTDFAYNMLKVIRKLnGV-VIFATQS---LDEVVK----NKIA-RAameVTETSIwmanpd 826
Cdd:COG0433   259 PLVLVIDEAHLLApaAPSALLEILERIAREGRKF-GVgLILATQRpsdIDEDVLsqlgTQIIlRL---FNPRDQ------ 328
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1319952606 827 adydDYVEKA--KVDPAHFNIIKTLDPGsrQFLVVksalrrGEVKKFAALVKFDL 879
Cdd:COG0433   329 ----KAVKAAaeTLSEDLLERLPSLGTG--EALVL------GEGIPLPVLVKIRL 371
TrbD COG5268
Type IV secretory pathway, TrbD component [Intracellular trafficking, secretion, and vesicular ...
4-62 1.34e-04

Type IV secretory pathway, TrbD component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 444081  Cd Length: 88  Bit Score: 41.43  E-value: 1.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1319952606   4 VYKALTRPTLLRGVPIAPFMLSVIAIAIIGLIVTKW-----LWLLIpalYFLMRRITSRDEHVF 62
Cdd:COG5268    13 VHRALTRPILLGGAPRELAILNGTLAAALGLGLQLWivglaLWLVG---HALAVWMAKRDPQFF 73
PRK13721 PRK13721
conjugal transfer ATP-binding protein TraC; Provisional
543-812 3.21e-03

conjugal transfer ATP-binding protein TraC; Provisional


Pssm-ID: 237480 [Multi-domain]  Cd Length: 844  Bit Score: 41.25  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 543 NAKIIGTAGAGKTMLLDMLayaMQKYRNHATFSpaakskrlttVFFDKDRGAEVAIRALGGEYYRiraGESSGWNPFA-L 621
Cdd:PRK13721  451 NMAVCGTSGAGKTGLIQPL---IRSVLDSGGFA----------VVFDMGDGYKSLCENMGGVYLD---GETLRFNPFAnI 514
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 622 ESTRRNRKFVKDLMKLIVTRRGqPLSDRQEDDLFQAV-------------DDV---MDMPLTQRQYGitqllsylnEPTT 685
Cdd:PRK13721  515 TDIDQSAERIRDQLSVMASPNG-NLDEVHEGLLLQAVraswlakknrariDDVvdfLKNARDSEQYA---------DSPT 584
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319952606 686 VEAQENGLRIRLKQWKQGGEFGWVFDNEADTFDvrnvdnfgiDGTEFL--------DDADTRAAISFYL-------LYRv 750
Cdd:PRK13721  585 IRSRLDEMIVLLDQYTANGTYGEYFNSDEPSLR---------DDARMVvlelggleDRPSLLVAVMFSLiiyienrMYR- 654
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1319952606 751 tSLLDGRRLVIImDEFWKWL--TSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNK---IARAA 812
Cdd:PRK13721  655 -TPRNLKKLNVI-DEGWRLLdfKNHKVGEFIEKGYRTARRHTGAYITITQNIVDFDSDKassAARAA 719
P-loop_TraG pfam19044
TraG P-loop domain; This entry represents the P-loop domain found in the TraG conjugation ...
754-812 3.55e-03

TraG P-loop domain; This entry represents the P-loop domain found in the TraG conjugation protein.


Pssm-ID: 436917 [Multi-domain]  Cd Length: 413  Bit Score: 40.97  E-value: 3.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1319952606 754 LDGRRLVIIMDEFWKWLTSDAFTDFAYNMLKVIRKLNGVVIFATQSLDEVVKNKIARAA 812
Cdd:pfam19044 247 LKGIRKMILIEEAWKAIAKEGMAEYIKYLFKTVRKFFGEAIVVTQEVDDIISSPIVKDA 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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