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Conserved domains on  [gi|1327222192|gb|PMN86155|]
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choline dehydrogenase [Vibrio sp. 10N.261.45.A6]

Protein Classification

choline dehydrogenase( domain architecture ID 11479750)

oxygen-dependent choline dehydrogenase catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate

EC:  1.1.99.1
Gene Ontology:  GO:0008812

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 1-572 0e+00

choline dehydrogenase; Validated


:

Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1078.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEKEPGLDGRELH 78
Cdd:PRK02106    2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDyrWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  79 CPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMElNPL 157
Cdd:PRK02106   82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELpGLEGWSYADCLPYFKKAETRDGGEDDYRGGDGPLSVTRGKPGT-NPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 158 YQAFIDAGKDAGYPETQDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEalvvkdqssk 237
Cdd:PRK02106  161 FQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFE---------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 238 gqsGLKAVGVEFEKSGNIQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNGVGENLQDHLEVYFQYH 317
Cdd:PRK02106  231 ---GKRAVGVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYE 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 318 CNEPITLNSKLGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVG 397
Cdd:PRK02106  308 CKQPVSLYPALKWWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVG 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 398 PNKPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDFYRGEEIQPGLNVTSDEAIDEWVKQN 477
Cdd:PRK02106  388 PMRSPSRGSVKLKSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREH 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 478 VESAYHPSCGCKMGSddDPMAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERASDLILGKSMLKDQDVPVW 557
Cdd:PRK02106  468 AETAYHPSCTCKMGT--DPMAVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYY 545

                         570
                  ....*....|....*
gi 1327222192 558 IAPEWEEKQRINKPV 572
Cdd:PRK02106  546 VAGDWPVRQRAQRPR 560
 
Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 1-572 0e+00

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1078.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEKEPGLDGRELH 78
Cdd:PRK02106    2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDyrWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  79 CPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMElNPL 157
Cdd:PRK02106   82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELpGLEGWSYADCLPYFKKAETRDGGEDDYRGGDGPLSVTRGKPGT-NPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 158 YQAFIDAGKDAGYPETQDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEalvvkdqssk 237
Cdd:PRK02106  161 FQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFE---------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 238 gqsGLKAVGVEFEKSGNIQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNGVGENLQDHLEVYFQYH 317
Cdd:PRK02106  231 ---GKRAVGVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYE 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 318 CNEPITLNSKLGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVG 397
Cdd:PRK02106  308 CKQPVSLYPALKWWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVG 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 398 PNKPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDFYRGEEIQPGLNVTSDEAIDEWVKQN 477
Cdd:PRK02106  388 PMRSPSRGSVKLKSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREH 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 478 VESAYHPSCGCKMGSddDPMAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERASDLILGKSMLKDQDVPVW 557
Cdd:PRK02106  468 AETAYHPSCTCKMGT--DPMAVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYY 545

                         570
                  ....*....|....*
gi 1327222192 558 IAPEWEEKQRINKPV 572
Cdd:PRK02106  546 VAGDWPVRQRAQRPR 560
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 1-546 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 768.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTDKSIFIQMPTALSYPMNTEKYAWQFETEKEPGLDGRELHCP 80
Cdd:COG2303     1 MLEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLIRMPAGYAKLLGNPRYDWRYETEPQPGLNGRRLYWP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  81 RGKVLGGSSSINGMVYVRGHACDFDQWEEEGAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMelNPLYQA 160
Cdd:COG2303    81 RGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGADAYHGRSGPLPVSDPPLP--NPLSDA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 161 FIDAGKDAGYPETQDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEalvvkdqsskgqs 240
Cdd:COG2303   159 FIEAAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFD------------- 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 241 GLKAVGVEFEKSGNIQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNGVGENLQDHLEVYFQYHCNE 320
Cdd:COG2303   226 GGRATGVEYRDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKE 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 321 PITLNSKLglvSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRY-DGQAAF-DGHGFQVHVGP 398
Cdd:COG2303   306 PVTLNKSL---RKARIGLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPrWGKKALhDGHGFTAHVEQ 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 399 NKPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDFYRGEEIQPGLNVTSDEAiDEWVKQNV 478
Cdd:COG2303   383 LRPESRGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEE-LAFIRARA 461

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1327222192 479 ESAYHPSCGCKMGSddDPMAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERASDLILGK 546
Cdd:COG2303   462 YTIYHPVGTCRMGT--DPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGD 527
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 6-549 0e+00

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 724.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   6 DYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEKEPGLDGRELHCPRGK 83
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGSDypWDLLIQMPAALAYPAGNKRYNWIYETEPEPHMNNRRVGHARGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  84 VLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMelNPLYQAFI 162
Cdd:TIGR01810  81 VLGGSSSINGMIYQRGNPMDYEKWAKPeGMESWDYADCLPYYKRLETTFGGEKPYRGHDGPIKVRRGPAD--NPLFQAFI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 163 DAGKDAGYPETQDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEalvvkdqsskgqsGL 242
Cdd:TIGR01810 159 EAGVEAGYNKTPDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAMKRPNLEVQTRAFVTKINFE-------------GN 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 243 KAVGVEFEKSGNIQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNGVGENLQDHLEVYFQYHCNEPI 322
Cdd:TIGR01810 226 RATGVEFKKGGRKEHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLPGVGENLQDHLEVYVQHACKQPV 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 323 TLNSKLGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVGPNKPE 402
Cdd:TIGR01810 306 SLYPSLNWLKQPFIGAQWLFGRKGAGASNHFEGGGFVRSNDDVDYPNIQYHFLPVAIRYDGTKAPKAHGFQVHVGPMYSN 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 403 SRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDFYRGEEIQPGLNVTSDEAIDEWVKQNVESAY 482
Cdd:TIGR01810 386 SRGHVKIKSKDPFEKPEIVFNYMSHEEDWREFREAIRVTREILKQKALDPYRGGEISPGPEVQTDEEIDEFVRRHGETAL 465

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1327222192 483 HPSCGCKMGSDDDPMAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERASDLILGKSML 549
Cdd:TIGR01810 466 HPCGTCKMGPASDEMSVVDPETRVHGMEGLRVVDASIMPRITNGNLNAPVIMMGEKAADIIRGKKPL 532
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 73-311 1.65e-55

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 186.72  E-value: 1.65e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  73 DGRELHCPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAEswnkggdeyrgdnGPVGTCNGND 151
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWASEfGLEGWGYDDYLPYMDKVE-------------GPLGVTTKGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 152 mELNPLYQAFIDAGKDAGYPE---TQDYNGYQQEGFGtmHMTVDKGVRASTSNAYLRRALKRsNLTLKKGIVARRFLLEa 228
Cdd:pfam00732  82 -EESPLNQALLKAAEELGYPVeavPRNSNGCHYCGFC--GLGCPTGAKQSTARTWLRPALER-NLRILTGAKAEKIIIL- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 229 lvvkdqsskgQSGLKAVGVEFEKSGNI--QVAVANKEVISSAGSIGSVQLLQLSGIGPKAvlekagvelkhelNGVGENL 306
Cdd:pfam00732 157 ----------GRGGRAVGVEARDGGGGikRLITAAKEVVVAAGALNTPPLLLRSGLGKNP-------------HPVGKNL 213


                  ....*
gi 1327222192 307 QDHLE 311
Cdd:pfam00732 214 QLHPV 218
 
Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 1-572 0e+00

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1078.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEKEPGLDGRELH 78
Cdd:PRK02106    2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDyrWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  79 CPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMElNPL 157
Cdd:PRK02106   82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELpGLEGWSYADCLPYFKKAETRDGGEDDYRGGDGPLSVTRGKPGT-NPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 158 YQAFIDAGKDAGYPETQDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEalvvkdqssk 237
Cdd:PRK02106  161 FQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFE---------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 238 gqsGLKAVGVEFEKSGNIQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNGVGENLQDHLEVYFQYH 317
Cdd:PRK02106  231 ---GKRAVGVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYE 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 318 CNEPITLNSKLGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVG 397
Cdd:PRK02106  308 CKQPVSLYPALKWWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVG 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 398 PNKPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDFYRGEEIQPGLNVTSDEAIDEWVKQN 477
Cdd:PRK02106  388 PMRSPSRGSVKLKSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREH 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 478 VESAYHPSCGCKMGSddDPMAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERASDLILGKSMLKDQDVPVW 557
Cdd:PRK02106  468 AETAYHPSCTCKMGT--DPMAVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYY 545

                         570
                  ....*....|....*
gi 1327222192 558 IAPEWEEKQRINKPV 572
Cdd:PRK02106  546 VAGDWPVRQRAQRPR 560
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 1-546 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 768.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTDKSIFIQMPTALSYPMNTEKYAWQFETEKEPGLDGRELHCP 80
Cdd:COG2303     1 MLEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLIRMPAGYAKLLGNPRYDWRYETEPQPGLNGRRLYWP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  81 RGKVLGGSSSINGMVYVRGHACDFDQWEEEGAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMelNPLYQA 160
Cdd:COG2303    81 RGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGADAYHGRSGPLPVSDPPLP--NPLSDA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 161 FIDAGKDAGYPETQDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEalvvkdqsskgqs 240
Cdd:COG2303   159 FIEAAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFD------------- 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 241 GLKAVGVEFEKSGNIQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNGVGENLQDHLEVYFQYHCNE 320
Cdd:COG2303   226 GGRATGVEYRDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKE 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 321 PITLNSKLglvSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRY-DGQAAF-DGHGFQVHVGP 398
Cdd:COG2303   306 PVTLNKSL---RKARIGLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPrWGKKALhDGHGFTAHVEQ 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 399 NKPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDFYRGEEIQPGLNVTSDEAiDEWVKQNV 478
Cdd:COG2303   383 LRPESRGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEE-LAFIRARA 461

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1327222192 479 ESAYHPSCGCKMGSddDPMAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERASDLILGK 546
Cdd:COG2303   462 YTIYHPVGTCRMGT--DPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGD 527
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 6-549 0e+00

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 724.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   6 DYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEKEPGLDGRELHCPRGK 83
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGSDypWDLLIQMPAALAYPAGNKRYNWIYETEPEPHMNNRRVGHARGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  84 VLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMelNPLYQAFI 162
Cdd:TIGR01810  81 VLGGSSSINGMIYQRGNPMDYEKWAKPeGMESWDYADCLPYYKRLETTFGGEKPYRGHDGPIKVRRGPAD--NPLFQAFI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 163 DAGKDAGYPETQDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEalvvkdqsskgqsGL 242
Cdd:TIGR01810 159 EAGVEAGYNKTPDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAMKRPNLEVQTRAFVTKINFE-------------GN 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 243 KAVGVEFEKSGNIQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNGVGENLQDHLEVYFQYHCNEPI 322
Cdd:TIGR01810 226 RATGVEFKKGGRKEHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLPGVGENLQDHLEVYVQHACKQPV 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 323 TLNSKLGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVGPNKPE 402
Cdd:TIGR01810 306 SLYPSLNWLKQPFIGAQWLFGRKGAGASNHFEGGGFVRSNDDVDYPNIQYHFLPVAIRYDGTKAPKAHGFQVHVGPMYSN 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 403 SRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDFYRGEEIQPGLNVTSDEAIDEWVKQNVESAY 482
Cdd:TIGR01810 386 SRGHVKIKSKDPFEKPEIVFNYMSHEEDWREFREAIRVTREILKQKALDPYRGGEISPGPEVQTDEEIDEFVRRHGETAL 465

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1327222192 483 HPSCGCKMGSDDDPMAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERASDLILGKSML 549
Cdd:TIGR01810 466 HPCGTCKMGPASDEMSVVDPETRVHGMEGLRVVDASIMPRITNGNLNAPVIMMGEKAADIIRGKKPL 532
Rv0697 TIGR03970
dehydrogenase, Rv0697 family; This model describes a set of dehydrogenases belonging to the ...
 6-544 1.11e-95

dehydrogenase, Rv0697 family; This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function.


Pssm-ID: 274888 [Multi-domain]  Cd Length: 487  Bit Score: 300.58  E-value: 1.11e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   6 DYIIVGAGSAGCVLADRLTESGEHSVLLLEAG---GTDKSIFIQMPTALSYPMN-TEKYAWQFETE--KEPGldgRELHC 79
Cdd:TIGR03970   2 DVLIVGAGSAGSVLAARLSEDPSCTVTVLEAGpgyRDPSRLPAQLTDGLRLPIGpASPVVWRYGVEltDGPR---RASQI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  80 PRGKVLGGSSSINGMVYVRGHACDFDQWeeeGAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTcnGNDMELNPLYQ 159
Cdd:TIGR03970  79 VRGRVLGGSGAVNGGYFCRALPADFDAW---PIPGWSWDDVLPHFRAIETDLDFDGPLHGTAGPIPV--RRTAELDGISA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 160 AFIDAGKDAGYPETQDYNGYQQE---GFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLealvvkdqss 236
Cdd:TIGR03970 154 AFVAAALGAGFGWIADLNGSGPGlpgGVGAVPLNVDGGRRVSTAVAYLLPALKRPNLTVEADTRVVRILF---------- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 237 kgqSGLKAVGVEFEKSGNIQVAVANKeVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNgVGENLQDHLEVYFQY 316
Cdd:TIGR03970 224 ---SGTRAVGVEVLGDGGPRTLRADR-VVLCAGAVESAHLLLLSGIGPAEQLRAAGIAVVLDLP-VGSDFVDHPEWVLPY 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 317 HCNEPITLNSKLGLVskgmigaEWILTrkglgaTNHFE----SCAFIRSRKGLkwPNIQYHFLPAAMRydgqaafdghgf 392
Cdd:TIGR03970 299 RWRPTHDRPPTSPVL-------ETVLN------TADIEirpyTAGFTALVPGS--PRDDPHLGVALMR------------ 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 393 qvhvgpnkPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPamdfyrgeEIQPGLNVTSDEAIDE 472
Cdd:TIGR03970 352 --------PHSRGRIRLASADPADPPRIEHRYDSSAADRAALRAGAALAHELLGSP--------ELGPLLEPAVREGEAS 415

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1327222192 473 WVKQNVESAYHPSCGCKMGSDDDPMAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERASDLIL 544
Cdd:TIGR03970 416 WVLARLATSQHLCGSCRMGGRDDPGAVVDARCRVRGVEGLWVVDGSILPVIPSRGPHATAVMVAERAAEFLG 487
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 73-311 1.65e-55

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 186.72  E-value: 1.65e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  73 DGRELHCPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAEswnkggdeyrgdnGPVGTCNGND 151
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWASEfGLEGWGYDDYLPYMDKVE-------------GPLGVTTKGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 152 mELNPLYQAFIDAGKDAGYPE---TQDYNGYQQEGFGtmHMTVDKGVRASTSNAYLRRALKRsNLTLKKGIVARRFLLEa 228
Cdd:pfam00732  82 -EESPLNQALLKAAEELGYPVeavPRNSNGCHYCGFC--GLGCPTGAKQSTARTWLRPALER-NLRILTGAKAEKIIIL- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 229 lvvkdqsskgQSGLKAVGVEFEKSGNI--QVAVANKEVISSAGSIGSVQLLQLSGIGPKAvlekagvelkhelNGVGENL 306
Cdd:pfam00732 157 ----------GRGGRAVGVEARDGGGGikRLITAAKEVVVAAGALNTPPLLLRSGLGKNP-------------HPVGKNL 213


                  ....*
gi 1327222192 307 QDHLE 311
Cdd:pfam00732 214 QLHPV 218
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 401-539 1.90e-48

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 165.26  E-value: 1.90e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 401 PESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDFYRG-----EEIQPGLNVTSDEAIDEWVK 475
Cdd:pfam05199   1 PRSRGRVTLSSSDPTGLPVIDPNYLSDPADLAALRAALRLARRILAAAGLVLGVEltpgpVPEVSDAAVTSDDELLAYIR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1327222192 476 QNVESAYHPSCGCKMGSDDDPmAVLDEECRVRGIDNLRVVDSSVFPTIPNGNLNAPTIMVAERA 539
Cdd:pfam05199  81 AAASTSYHPMGTCRMGADPDD-AVVDPDLRVHGVDNLRVVDASVFPSSPSGNPTLTIYALAERA 143
PLN02785 PLN02785
Protein HOTHEAD
 5-538 2.69e-28

Protein HOTHEAD


Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 119.14  E-value: 2.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192   5 YDYIIVGAGSAGCVLADRLteSGEHSVLLLEAGGT-----DKSIFIQMPTALSYPMNTEKYAWQFETekepglDGreLHC 79
Cdd:PLN02785   56 YDYIVVGGGTAGCPLAATL--SQNFSVLLLERGGVpfgnaNVSFLENFHIGLADTSPTSASQAFIST------DG--VIN 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192  80 PRGKVLGGSSSINGMVYVRGHAcDFDQweeegAAGWNYQ---ACLPYF-RRAESWNKggdeyrgdngpvgtcngndmeLN 155
Cdd:PLN02785  126 ARARVLGGGTCINAGFYSRAST-RFIQ-----KAGWDAKlvnESYPWVeRQIVHWPK---------------------VA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 156 PLYQAFIDAGKDAGypeTQDYNGYQQEG-FGT-MHMTV-DKGVRASTSnAYLRRALKRSNLtlkkgivarRFLLEALVVK 232
Cdd:PLN02785  179 PWQAALRDSLLEVG---VSPFNGFTYDHvYGTkVGGTIfDEFGRRHTA-AELLAAGNPNKL---------RVLLHATVQK 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 233 DQSSKGQSGLKAVGVEF--EKSGNIQVAVANK---EVISSAGSIGSVQLLQLSGIGPKAVLEKAGVELKHELNGVGENLQ 307
Cdd:PLN02785  246 IVFDTSGKRPRATGVIFkdENGNQHQAFLSNNkgsEIILSAGAIGSPQMLLLSGIGPKKELKKHKIPVVLHNEHVGKGMA 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 308 DHLEVYFQYHCNEPI--TLNSKLGLVSKGMigaeWILTRKGLGatnhfESCAFIRSRKGLKWPNI-QYHFLPAAMR---- 380
Cdd:PLN02785  326 DNPMNSIFVPSKAPVeqSLIQTVGITKMGV----YIEASSGFG-----QSPDSIHCHHGIMSAEIgQLSTIPPKQRtpea 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 381 ---------YDGQAAFDGhGFQVHVGPNkPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREIL-SQPAM 450
Cdd:PLN02785  397 iqayihrkkNLPHEAFNG-GFILEKIAG-PISTGHLSLINTNVDDNPSVTFNYFKHPQDLQRCVYGIRTIEKIVkTNHFT 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327222192 451 DFYRGEE----------IQPGLNV----TSD-EAIDEWVKQNVESAYHPSCGCKMGSdddpmaVLDEECRVRGIDNLRVV 515
Cdd:PLN02785  475 NFTQCDKqtmekvlnmsVKANINLipkhTNDtKSLEQFCKDTVITIWHYHGGCHVGK------VVDQNYKVLGVSRLRVI 548

                         570       580
                  ....*....|....*....|...
gi 1327222192 516 DSSVFPTIPNGNLNApTIMVAER 538
Cdd:PLN02785  549 DGSTFDESPGTNPQA-TVMMMGR 570
Glf COG0562
UDP-galactopyranose mutase [Cell wall/membrane/envelope biogenesis];
5-35 7.66e-06

UDP-galactopyranose mutase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440328 [Multi-domain]  Cd Length: 365  Bit Score: 48.17  E-value: 7.66e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1327222192   5 YDYIIVGAGSAGCVLADRLTESGEHSVLLLE 35
Cdd:COG0562     3 YDYLIVGAGFFGAVFAERLAEELGKKVLVID 33
PRK06370 PRK06370
FAD-containing oxidoreductase;
1-39 7.81e-05

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 45.19  E-value: 7.81e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1327222192   1 MEQRYDYIIVGAGSAGCVLADRLTESGeHSVLLLEA---GGT 39
Cdd:PRK06370    2 PAQRYDAIVIGAGQAGPPLAARAAGLG-MKVALIERgllGGT 42
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
3-38 8.49e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 44.90  E-value: 8.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1327222192   3 QRYDYIIVGAGSAGCVLADRLTESGeHSVLLLEAGG 38
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARRG-LDVTVLERGR 35
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 5-35 1.29e-03

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 41.15  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1327222192   5 YDYIIVGAGSAGCVLADRLTESGeHSVLLLE 35
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKG-LRVLLLE 30
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
1-36 2.41e-03

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 40.51  E-value: 2.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1327222192   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEA 36
Cdd:COG0579     1 MMEMYDVVIIGAGIVGLALARELSRYEDLKVLVLEK 36
Lycopene_cycl pfam05834
Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. ...
 6-73 3.18e-03

Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclization of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare.


Pssm-ID: 310433 [Multi-domain]  Cd Length: 380  Bit Score: 40.09  E-value: 3.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1327222192   6 DYIIVGAGSAGCVLADRLTESGEH-SVLLLEAGGTdksifiqmptalsyPMNTEKYAWQFETEKEPGLD 73
Cdd:pfam05834   1 DVVIIGAGPAGLSLAARLAAAKPGlSVVLIEPGPS--------------LLRPNNYVWSDEFEDLGALE 55
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 2-39 4.34e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 39.68  E-value: 4.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1327222192   2 EQRYDYIIVGAGSAGCVLADRLTESGEhSVLLLEA---GGT 39
Cdd:COG1249     1 MKDYDLVVIGAGPGGYVAAIRAAQLGL-KVALVEKgrlGGT 40
PTZ00367 PTZ00367
squalene epoxidase; Provisional
 5-35 5.39e-03

squalene epoxidase; Provisional


Pssm-ID: 240384 [Multi-domain]  Cd Length: 567  Bit Score: 39.45  E-value: 5.39e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1327222192   5 YDYIIVGAGSAGCVLADRLTESGEhSVLLLE 35
Cdd:PTZ00367   34 YDVIIVGGSIAGPVLAKALSKQGR-KVLMLE 63
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
4-38 5.60e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 39.52  E-value: 5.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1327222192   4 RYDYIIVGAGSAGCVLADRLTESGeHSVLLLEA----GG 38
Cdd:COG1231     7 GKDVVIVGAGLAGLAAARELRKAG-LDVTVLEArdrvGG 44
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-39 6.01e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 39.08  E-value: 6.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1327222192   1 MEQRYDYIIVGAGSAGCVLADRLTESGeHSVLLLEA----GGT 39
Cdd:COG2072     3 ATEHVDVVVIGAGQAGLAAAYHLRRAG-IDFVVLEKaddvGGT 44
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
9-37 7.16e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 35.20  E-value: 7.16e-03
                          10        20
                  ....*....|....*....|....*....
gi 1327222192   9 IVGAGSAGCVLADRLTESGeHSVLLLEAG 37
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRG-FRVLVLEKR 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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