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Conserved domains on  [gi|1327256361|gb|PMO19215|]
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hypothetical protein BCT17_21630 [Vibrio sp. 10N.222.54.F10]

Protein Classification

6-pyruvoyl trahydropterin synthase family protein( domain architecture ID 10002285)

6-pyruvoyl tetrahydropterin synthase (PTPS) family protein similar to 6-carboxy-5,6,7,8-tetrahydropterin synthase that catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde, and dihydroneopterin monophosphate aldolase that catalyzes the conversion of 7,8-dihydroneopterin monophosphate (H2NMP) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)

CATH:  3.30.479.10
EC:  4.1.2.-
Gene Ontology:  GO:0016829|GO:0046872
PubMed:  10737935|21999246
SCOP:  4001717

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
QueD COG0720
6-pyruvoyl-tetrahydropterin synthase [Coenzyme transport and metabolism]; ...
 26-151 2.88e-08

6-pyruvoyl-tetrahydropterin synthase [Coenzyme transport and metabolism]; 6-pyruvoyl-tetrahydropterin synthase is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440484  Cd Length: 123  Bit Score: 51.35  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327256361  26 SWILDVTMSGE-LNEMSMVLDFSKVKKQIKHLVDEhVDHRLLLPmqsaaivlqaskagyskvdvlrgDKSLHLHCPdeay 104
Cdd:COG0720    30 NYRVEVTVEGEeLDETGMVVDFGDLKAALKEVIDR-LDHRFLNE-----------------------LPDLEGLNP---- 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1327256361 105 clidaeaiTIESVTAHVYNILRDNLPNNVTGLEITLrHENI-NGAFYH 151
Cdd:COG0720    82 --------TAENLARWIWDRLAPRLPGGVRLLRVRV-YETPtNWAEYE 120
 
Name Accession Description Interval E-value
QueD COG0720
6-pyruvoyl-tetrahydropterin synthase [Coenzyme transport and metabolism]; ...
 26-151 2.88e-08

6-pyruvoyl-tetrahydropterin synthase [Coenzyme transport and metabolism]; 6-pyruvoyl-tetrahydropterin synthase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440484  Cd Length: 123  Bit Score: 51.35  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327256361  26 SWILDVTMSGE-LNEMSMVLDFSKVKKQIKHLVDEhVDHRLLLPmqsaaivlqaskagyskvdvlrgDKSLHLHCPdeay 104
Cdd:COG0720    30 NYRVEVTVEGEeLDETGMVVDFGDLKAALKEVIDR-LDHRFLNE-----------------------LPDLEGLNP---- 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1327256361 105 clidaeaiTIESVTAHVYNILRDNLPNNVTGLEITLrHENI-NGAFYH 151
Cdd:COG0720    82 --------TAENLARWIWDRLAPRLPGGVRLLRVRV-YETPtNWAEYE 120
PTPS pfam01242
6-pyruvoyl tetrahydropterin synthase; 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the ...
 24-66 1.20e-05

6-pyruvoyl tetrahydropterin synthase; 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.


Pssm-ID: 460129  Cd Length: 121  Bit Score: 43.72  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1327256361  24 GDSWILDVTMSGE-LNEMSMVLDFSKVKKQIKHlVDEHVDHRLL 66
Cdd:pfam01242  26 GHNYRVEVTVRGEeLDETGMVVDFGELKKAVKE-VLDRLDHRFL 68
 
Name Accession Description Interval E-value
QueD COG0720
6-pyruvoyl-tetrahydropterin synthase [Coenzyme transport and metabolism]; ...
 26-151 2.88e-08

6-pyruvoyl-tetrahydropterin synthase [Coenzyme transport and metabolism]; 6-pyruvoyl-tetrahydropterin synthase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440484  Cd Length: 123  Bit Score: 51.35  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327256361  26 SWILDVTMSGE-LNEMSMVLDFSKVKKQIKHLVDEhVDHRLLLPmqsaaivlqaskagyskvdvlrgDKSLHLHCPdeay 104
Cdd:COG0720    30 NYRVEVTVEGEeLDETGMVVDFGDLKAALKEVIDR-LDHRFLNE-----------------------LPDLEGLNP---- 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1327256361 105 clidaeaiTIESVTAHVYNILRDNLPNNVTGLEITLrHENI-NGAFYH 151
Cdd:COG0720    82 --------TAENLARWIWDRLAPRLPGGVRLLRVRV-YETPtNWAEYE 120
PTPS pfam01242
6-pyruvoyl tetrahydropterin synthase; 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the ...
 24-66 1.20e-05

6-pyruvoyl tetrahydropterin synthase; 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.


Pssm-ID: 460129  Cd Length: 121  Bit Score: 43.72  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1327256361  24 GDSWILDVTMSGE-LNEMSMVLDFSKVKKQIKHlVDEHVDHRLL 66
Cdd:pfam01242  26 GHNYRVEVTVRGEeLDETGMVVDFGELKKAVKE-VLDRLDHRFL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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