|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
4-423 |
1.14e-121 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 360.72 E-value: 1.14e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 4 THKDYLKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLA 83
Cdd:cd13136 1 LHREILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 84 GSLMRPFVLSGLVGLIFILIQ-PLIWqGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQ 162
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLQsPLLA-LALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 163 VFGNVLNIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSNISISEFLQgSKMTKKDLSTIISSNTDLLLRT 242
Cdd:cd13136 160 IVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSR-RLPSKAALKRLFKLNRDIFIRT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 243 ICILVFFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAVL 322
Cdd:cd13136 239 LALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 323 TFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATLLVFLAVQALSIDMW 402
Cdd:cd13136 319 ALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLVPLW 398
|
410 420
....*....|....*....|.
gi 1327307398 403 GNHGLWLAFTLFYLGRIAFLY 423
Cdd:cd13136 399 GNHGLWLALILFMLLRGLTLA 419
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
4-425 |
2.27e-73 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 236.58 E-value: 2.27e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 4 THKDYLKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELiGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLA 83
Cdd:COG0534 6 ILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAAL-AAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEAR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 84 GSLMRPFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQV 163
Cdd:COG0534 85 RVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 164 FGNVLNIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSNIsISEFLQGSKMTKKDLSTIISSNTDLLLRTI 243
Cdd:COG0534 165 IGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSL-LRLRLRDLRPDRKILKRILRIGLPAGLQQL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 244 CILVFFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAVLT 323
Cdd:COG0534 244 AESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 324 FLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATLLVFL--AVQALSIDM 401
Cdd:COG0534 324 LLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRlpLAYLLAFLG 403
|
410 420
....*....|....*....|....
gi 1327307398 402 WGNHGLWLAFTLFYLGRIAFLYPF 425
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLLLR 427
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
1-418 |
3.07e-62 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 208.05 E-value: 3.07e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 1 MTITHKDYLKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRS 80
Cdd:PRK10367 4 LTSSDKALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 81 DLAGSLMRPFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLY 160
Cdd:PRK10367 84 ALARALVQPLLLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 161 TQVFGNVLNIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSNISISEFLQGSKMTKKDLSTIISSNTDLLL 240
Cdd:PRK10367 164 LLVVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLLIGLLMVRKVLKLRGISLEMLKTAWRGNFRRLLALNRDIML 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 241 RTICILVFFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIA 320
Cdd:PRK10367 244 RSLLLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQLLDVWRAACRQSGIVAL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 321 VLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATLLVFlAVQALSID 400
Cdd:PRK10367 324 LFSLVYALAGEHIIALLTSLPQIQQLADRYLIWQVILPLVGVWCYLLDGMFIGATRAAEMRNSMAVAAAGF-ALTLLTLP 402
|
410
....*....|....*...
gi 1327307398 401 MWGNHGLWLAFTLFYLGR 418
Cdd:PRK10367 403 WLGNHGLWLALTVFLALR 420
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
14-355 |
2.14e-39 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 144.70 E-value: 2.14e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 14 PFIISTVTQPLLGAVDTAVIGQLGIAELiGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMRPFVLS 93
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDL-AAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 94 GLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVLNIVLD 173
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 174 AVFVL--YFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSNISISEFLQgSKMTKKDLSTIISSNTDLLLRTICILVFFNM 251
Cdd:TIGR00797 160 YILIFgkFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGL-LKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 252 MARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAVLTFLTLVFKD 331
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330 340
....*....|....*....|....
gi 1327307398 332 SIVFLFTDIPTLVALYQEMAPWLI 355
Cdd:TIGR00797 319 FIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-423 |
4.17e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 129.55 E-value: 4.17e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGiAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:cd13137 4 WSLAWPVILENLLQTLVGLVDVFMVGRLG-AEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVL 168
Cdd:cd13137 83 SLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 169 NIVLDAVFVLY----FDLGVAGVAYASLIAQVTTFAIGMTLVIKTSN---ISISEFLQGSKMTKKDLSTIISSNTDLLLR 241
Cdd:cd13137 163 NIVLDYVLIFGlwgfPGLGVAGAALATVISRVVGALLLLFLLLRGRLpikISFKGFRLDRKIIKKLLRIGLPAGLEQLLR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 242 TICILVFFNMMARtgskLGADVLAANAILMQVtFIVSYM-FDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIA 320
Cdd:cd13137 243 SLGFLVLLAIVAS----YGTAALAAYQIGLRI-ESLAFMpGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 321 VLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATLLVF---LAVQAL 397
Cdd:cd13137 318 LLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVrlpLAYLLG 397
|
410 420
....*....|....*....|....*.
gi 1327307398 398 SIDMWGNHGLWLAFTLFYLGRIAFLY 423
Cdd:cd13137 398 FVLGLGLTGIWLAMFVDTIVRAILLL 423
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
12-426 |
2.45e-31 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 124.36 E-value: 2.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 12 AFPFIISTVTQPLLGAVDTAVIGQLGIAELiGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMRPFV 91
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDAL-AAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 92 LSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVLNIV 171
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 172 LDAVFVLYF---DLGVAGVAYASLIAQVTTFAIGMTLVIKtSNISISEFLQGSKMTKKDLSTIISSNTDLLLRTICILVF 248
Cdd:cd12082 160 LDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRK-GKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 249 FNMMAR-TGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAVLTFLTL 327
Cdd:cd12082 239 LLIIVAiVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 328 VFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATLLVFLAVQA--LSIDMWGNH 405
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAyvLAYLGLGLY 398
|
410 420
....*....|....*....|.
gi 1327307398 406 GLWLAFTLFYLGRIAFLYPFI 426
Cdd:cd12082 399 GIWLALVISLILAALVLLLFF 419
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-416 |
2.90e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 124.56 E-value: 2.90e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 2 TITHKDYLKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELiGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSD 81
Cdd:cd13133 1 PGGYREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVAL-AASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 82 LAGSLMRPFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYT 161
Cdd:cd13133 80 IGRVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 162 QVFGNVLNIVLDAVFVL----YFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSNISISEFLQGSKMTKKDLSTIIS---- 233
Cdd:cd13133 160 NLVMVVVNIVLDYALIFgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFDRELLRRILRlglp 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 234 SNTDLLLRTICILVFFNMMARtgskLGADVLAANAILMQVtFIVSYMF-DGIANASSVFAGKAVGQKNPSMLDRVLRLNF 312
Cdd:cd13133 240 SGLQFFLDVGAFTVFFLLIGR----LGTTELAATNIVFSI-NSLAFLPmIGLGIAVSSLVGQALGAGRPDLAMRVTRRGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 313 QWTASFIAVLTFLTLVFKDSIVFLFTDIPTlVALYQEMAPWLI----VFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATL 388
Cdd:cd13133 315 KLALAYMLLLGILFLLFPELLLSIFTPGAD-FALIAELAVPLLrfvaAYILFDALALVFAGALRGAGDTRFVMLAELIVA 393
|
410 420 430
....*....|....*....|....*....|
gi 1327307398 389 LVFLAVQA--LSIDMWGNHGLWLAFTLFYL 416
Cdd:cd13133 394 WLYLLPPAylLVVLGAGLAGAWTVETVYVI 423
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-411 |
7.98e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 120.26 E-value: 7.98e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:cd13138 6 LLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVL 168
Cdd:cd13138 86 LLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 169 NIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSN---ISISEFlqgsKMTKKDLSTIISSNTDLLLRTICI 245
Cdd:cd13138 166 NIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLpfkLSLKDF----RFDKEILKEILKIGLPSALQQSLV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 246 LVFFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAVLTFL 325
Cdd:cd13138 242 SISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 326 TLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATLLVF---LAVQALSIDMW 402
Cdd:cd13138 322 VFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVripLAYLLSRLTGL 401
|
....*....
gi 1327307398 403 GNHGLWLAF 411
Cdd:cd13138 402 GLFGIWLAM 410
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
8-413 |
3.82e-28 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 115.30 E-value: 3.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 8 YLKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSD----LA 83
Cdd:cd13143 6 FLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKanriFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 84 GSLMRPFVLSGLVGLIFILIQP--LIWQGAmwviepEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYT 161
Cdd:cd13143 86 TALLLSLILGLLLTILGLLFLDplLRLLGA------SGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 162 QVFGNVLNIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGMT-LVIKTSNISISefLQGSKMTKKDLSTIISSNTDLLL 240
Cdd:cd13143 160 MLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLyFFRGKSLLKLS--LLRFKLSLKIIKEILALGFPSFL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 241 R----TICILVFFNMMARTGsklGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTA 316
Cdd:cd13143 238 MqlssSVVTIVLNLTLLGYG---GDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 317 SFIAVLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGttrpvrDSSIATLLVFLAVQA 396
Cdd:cd13143 315 IYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIG------KAKRAALLSLLRQGL 388
|
410 420
....*....|....*....|....
gi 1327307398 397 LSIDM-------WGNHGLWLAFTL 413
Cdd:cd13143 389 FLIPLllilprlFGLDGIWLAFPL 412
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-413 |
3.87e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 112.60 E-value: 3.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGiAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:cd13134 6 FALAWPIFIELLLQMLLGTIDTFMLSRYS-DNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVL 168
Cdd:cd13134 85 ALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNIL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 169 NIVLDAVFVLYF----DLGVAGVAYASLIAQVTTFAIGMTLVIKTSNISISeFLQGSKMTKKDLSTIIS----SNTDLLL 240
Cdd:cd13134 165 NIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFR-LKDLRPFPKKLLKKILKiglpSAGEELS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 241 RTICILVFFNMMARtgskLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIA 320
Cdd:cd13134 244 YNLSQTVITAFIAR----LGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 321 VLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTR-PVRDS-----SIATLLVFLAV 394
Cdd:cd13134 320 AVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARfPVLIGiismwGISVPLAYLLG 399
|
410
....*....|....*....
gi 1327307398 395 QALSidmWGNHGLWLAFTL 413
Cdd:cd13134 400 IVLG---LGLLGVWIAFAA 415
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
9-378 |
7.67e-25 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 106.04 E-value: 7.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELiGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:cd13131 6 LRLALPILIAQLAQMAMGFVDTVMAGRLGADDL-AAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILiqpLIWQGAMW--VIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGN 166
Cdd:cd13131 85 GLWLALLLSLPLML---LLWLAPPIlpLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 167 VLNIVLDAVFVL----YFDLGVAGVAYASLIAQVTTFAIGMTLVIKtsNISISEFLQGSKMTKKDLSTIISsntdlLLRT 242
Cdd:cd13131 162 VLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRR--HKRFRRYRLFARFWRPDWARLKE-----LLRL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 243 ---ICILVFFNMMARTG-----SKLGADVLAANAILMQVTFIVsYMFD-GIANASSVFAGKAVGQKNPSMLDRVLRLNFQ 313
Cdd:cd13131 235 glpIGLTIFFEVSLFAAvallmGRLGTTVLAAHQIALNFASLL-FMVPlGISMAATVRVGFALGAGDPADARRAGLVGLG 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1327307398 314 WTASFIAVLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTR 378
Cdd:cd13131 314 LGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTR 378
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-413 |
5.52e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 88.74 E-value: 5.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELiggVAIGTIIMNTmyWL-FGFFRVSTTGQS---AMALGKGNRSDLAG 84
Cdd:cd13140 8 LRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAV---AAVGTAGFFV--WLaYALALLSKIGAQvkvSQSIGAKDEKEARK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 85 SLMRPFVLSGLVGLIFILIQ-----PLIwqGAMWVIEPEakVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVL 159
Cdd:cd13140 83 YARNALQLNLLLGILYGLLLllfakPLI--GFFNLGDAE--VISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 160 YTQVFGNVLNIVLDAVFVLYFD----LGVAGVAYASLIAQVTTFAIGMtLVIKTSNISISEFLQGSKMTKKDLSTIISSN 235
Cdd:cd13140 159 IINAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFL-YALKKKKGLFLKIRILKRPDRKYIKEILKLG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 236 TDLLLRTICILVFFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWT 315
Cdd:cd13140 238 LPVALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 316 ASFIAVLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIA--TLLVFLA 393
Cdd:cd13140 318 SAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVfnGLRIPLA 397
|
410 420
....*....|....*....|
gi 1327307398 394 VqALSIDMWGNHGLWLAFTL 413
Cdd:cd13140 398 L-LLSPTGLGLNGIWWAISI 416
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-413 |
2.48e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 86.86 E-value: 2.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAEliggVAIGTIIMNTMYWLFGF---FRVSTTGQSAMALGKGN---RSDL 82
Cdd:cd13142 14 LKLAWPIIVSNLLQVAYNLADTFWLGRLGADA----VAAPSISWPLIFLFISLgggLTVAGTALVAQYTGAGDydkANKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 83 AGSLmrpFVLSGLVGLIF-ILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYT 161
Cdd:cd13142 90 AGQT---FSFVIILSLILaVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 162 QVFGNVLNIVLDAVFVLYF----DLGVAGVAYASLIAQVTTFAIGMTLVIKTS---NISISEFLQGSKMTKKDLSTIISS 234
Cdd:cd13142 167 MFGSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRvglKISLRDLKPDWEWLKKIFRIGLPS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 235 NTDLLLRTICilvfFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQW 314
Cdd:cd13142 247 SIEQSARALG----FTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 315 TASFIAVLTFLTLVFKDSIVFLFTDIPTLVALYQEMapWLIVFPLVSGFGL--TVYGIFTGTGTTRPVRDSSIATL---- 388
Cdd:cd13142 323 IFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADF--LRIVAPSFPFFGLfqVINGAFRGSGHTLTAMIISILRLwvir 400
|
410 420
....*....|....*....|....*..
gi 1327307398 389 --LVFLAVQALSidmWGNHGLWLAFTL 413
Cdd:cd13142 401 ipLAYLLAYVLG---LGVTGIWIAMAI 424
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
9-375 |
1.60e-16 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 81.08 E-value: 1.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELiGGVAIGTIIMNtmywLFGFFRVSTTGqSAM------ALGKGNRSDL 82
Cdd:cd13132 6 LRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLEL-AAASLASSFAN----VTGFSILLGLA-SALdtlcgqAFGAKNYKLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 83 AGSLMRPFVLSGLvglIFILIQPLIWQGA--MWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLY 160
Cdd:cd13132 80 GVYLQRALVILLL---CCVPISLLWLNTEpiLLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 161 TQVFGNVLNIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSN-------ISISEFLQGSKMTKKDLSTIIS 233
Cdd:cd13132 157 ISLVALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGhkatwggFSREAFRGWGPFLKLAIPSALM 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 234 SNTDLLLRTICILVffnmmarTGSKLGADVLAANAILMQVTfIVSYMFD-GIANASSVFAGKAVGQKNPsmldRVLRLNF 312
Cdd:cd13132 237 LCLEWWAFEILVLL-------AGLLPGTVALAAQSICLTTT-SLLYMIPlGISIAASVRVGNELGAGNP----KRAKLAA 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1327307398 313 QW----TASFIAVLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTG 375
Cdd:cd13132 305 IValilSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCG 371
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
9-375 |
2.21e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 77.58 E-value: 2.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELiggVAIGTIIMNTMYwLFGF-FRVSTTGQSAMA--LGKGNRSDLAGS 85
Cdd:cd13147 12 IKLSIPMIIAMLLQTLYNLVDAIWVAGLGADAL---AAIGFVFPLFMI-IIGLgNGLGAGASSAISrrIGAKDKEGADNA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 86 LMRPFVLSGLVGLIFILIQpLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFG 165
Cdd:cd13147 88 AVHSILLGLIISIILTIVL-LPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 166 NVLNIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGM--TLVIKTSNISIS--EFLQGSKMTKKDLSTIISSNTDLLLR 241
Cdd:cd13147 167 SILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLywFFVKKDTYVSLSlkNFKFDKKIVKDILKVGIPASLEQLIM 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 242 TICILVFFNMMARTGSKLGADVLAANAILMQVTFIVSYmfdGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAV 321
Cdd:cd13147 247 SVLMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLI---GIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELI 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1327307398 322 LTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLV---SGFGLTVYGIFTGTG 375
Cdd:cd13147 324 IAILIFIFAPQIAYLFTYSEESAHLAPEIVAFLRIMCLFlpfVPFGMMSSSMFQGIG 380
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-375 |
2.15e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 74.75 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAE--LIGGVA-IGTIIMNTMYWLFGFFrVSTTGQSAMALGKGNRSDLAGS 85
Cdd:cd13146 11 IRLALPILIGQLFQLLYNITDTIWISMIDPSDpaLVGGIGlVFPLGMIFLALGNGIQ-VGVSSLLARAIGAQRAKELDQA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 86 LMRPFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFG 165
Cdd:cd13146 90 ADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 166 NVLNIVLDAVFVLYFDLGVAGVAYASLIAQVTTFA-IGMTLVIKTSNISISefLQGSKMTKKDLSTIISSNTDLLLRTIC 244
Cdd:cd13146 170 TVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLyLLYVFLIGKSNVTIH--IKLSNISSSVIVEILRVGLPQMLLQLI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 245 ILVFFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAVLTF 324
Cdd:cd13146 248 SSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVL 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1327307398 325 LTLVFKDSIVFLFTDIPTLVALYQEMAPWL-IVFPLVSgFGLTVYGIFTGTG 375
Cdd:cd13146 328 GYVLVAPWLFSLFTTVPEVVAYAVLQVRTMaLALPFVA-ISILVTEFFQAIG 378
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-419 |
1.20e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 72.26 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGgVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:cd13144 11 LTMSIPAMISMLFQALYNIVDSIFVARLGENALTA-VSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVL 168
Cdd:cd13144 90 GLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAII 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 169 NIVLDAVFVLYF----DLGVAGVAYASLIAQVTTFAIGMTLVIKTSNISISEFlqgsKMTKKDLSTIissntdlllRTIC 244
Cdd:cd13144 170 NIILDPILIFGLfgfpAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDL----RLFRPSLRII---------KEIY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 245 ILVFFNMMARTGSKLGADVLaaNAILMQV---------------TFIVSYMFdGIANASSVFAGKAVGQKNPSMLDRVLR 309
Cdd:cd13144 237 AVGLPSIIMQAISSVMVFGL--NKILAGFgptavavfgiyfklqSFVFMPVF-GLNNGLIPIVAYNYGAGNKDRIREAIK 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 310 LNFQWTASFIAVLTFLTLVFKDSIVFLFTDIPTLVAL-YQEMAPWLIVFPLVsGFGLTVYGIFTGTGTTRPVRDSSIATL 388
Cdd:cd13144 314 YAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIgVPALRIISLSFLFA-ALSIILSGLFQALGRGVYSLIISVARQ 392
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1327307398 389 LVFLAVQALSID-MWGNHGLWLAF----------TLFYLGRI 419
Cdd:cd13144 393 LVVLLPLAWLLAkMFGLNGVWWSFpiaeivsfllSLLFLKRL 434
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-410 |
2.04e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 71.87 E-value: 2.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 12 AFPFIISTVTQPLLGAVDTAVIGQLGiAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMRPFV 91
Cdd:cd13139 20 AIPMVLEMVMESLFAVVDLYFVSRLG-ALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAIL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 92 LSGLVGLIFILI------QPLIWQGAmwviepEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFG 165
Cdd:cd13139 99 LGVALSLILSILgyffaeDILSLMGA------SPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 166 NVLNIVLDAVFVLYF----DLGVAGVAYASLIA-------QVTTFAIGMTLViktsNISISEFLQGSKMTKKDLSTIISS 234
Cdd:cd13139 173 NGLNIILDPLFIFGLgpipAMGVTGAAIATTIGrsigvlyQLYHLFKGKGRI----QIRRRHLKLDWAIIKKIIKIAVGG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 235 NTDLLLRTICILVffnmMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQW 314
Cdd:cd13139 249 ILQFLIASSSWIF----LVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKY 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 315 TASFIAVLTFLTLVFKDSIVFLFTDIPTlVALYQEMAPWLIVFPLVS-GFGLTVYGIFTGTGTTRPVrdsSIATLLVFLA 393
Cdd:cd13139 325 NMVFLGIVSLVFFLFAEPLVSFFTTDPE-VIAIAVEALRIISLGYIFyGYGMVLSQAFNGAGDTKTP---TLINLVGFWL 400
|
410 420
....*....|....*....|...
gi 1327307398 394 VQA-----LSIDM-WGNHGLWLA 410
Cdd:cd13139 401 FQIplaylLARHLnLGPKGVFIA 423
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
14-175 |
4.05e-12 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 64.12 E-value: 4.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 14 PFIISTVTQPLLGAVDTAVIGQLGIAELiGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMRPFVLS 93
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVAL-AAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 94 GLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVLNIVLD 173
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 1327307398 174 AV 175
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-392 |
6.31e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 66.96 E-value: 6.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYwLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:cd13141 14 ISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMA-LTQVLNVGTAALVSHAVGRKDQGEANAVFNQ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVL 168
Cdd:cd13141 93 SLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 169 NIVLDAVFV----LYFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSN---ISISEFLQGSKMTKKDLSTIISSNTDLLLr 241
Cdd:cd13141 173 NIILAPILItgwgTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKylrLDLALWRPDLPTWKRLLKIGLPSGGEFLL- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 242 ticILVFFNMMARTGSKLGADVLAANAI---LMQVTFIVSYmfdGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASF 318
Cdd:cd13141 252 ---TFVYMAVIYWALRPFGAAAQAGFGIgsrIMQSLFLPAM---AIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTAL 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1327307398 319 IAVLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATLLVFL 392
Cdd:cd13141 326 MLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFA 399
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
257-390 |
2.18e-09 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 56.03 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 257 SKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAVLTFLTLVFKDSIVFL 336
Cdd:pfam01554 21 GHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLVLLFSEPILSL 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1327307398 337 FTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYGIFTGTGTTRPVRDSSIATLLV 390
Cdd:pfam01554 101 FGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLL 154
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-345 |
3.10e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 58.46 E-value: 3.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 6 KDYLKIAFPFIISTVTQPLLGAVDTAVIGQLGIaELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGS 85
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISI-RYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 86 LMRPFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFG 165
Cdd:cd13135 80 AISSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 166 NVLNIVLDAVFVL----YFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSNISISEFLQGSKMTK-KDLSTIISSNTDLLL 240
Cdd:cd13135 160 NLLNVILDYVLIFgnfgFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANiRPYKFTIKLGLPLGG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 241 RTICILVFFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIA 320
Cdd:cd13135 240 EEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYI 319
|
330 340
....*....|....*....|....*
gi 1327307398 321 VLTFLTLVFKDSIVFLFTDIPTLVA 345
Cdd:cd13135 320 AAAIVFLAFPYKILSLFTNDPELIN 344
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
9-346 |
9.26e-09 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 57.13 E-value: 9.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELiGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:PRK01766 15 LALALPILLAQVAQTAMGFVDTVMAGGVSATDL-AAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQVRQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVG--LIFILIQPLIWQGAMWVIEPEakVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGN 166
Cdd:PRK01766 94 GLWLALFLSvlIMLVLYNAVPPILNMMNLEPE--VADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGFLGL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 167 VLNIVLDAVFVL-YF---DLGVAGVAYASLIAQVTTFAIgMTLVIKTSNiSISEFLQGSKMTKKDLSTIISsntdlLLRT 242
Cdd:PRK01766 172 LINIPLNYIFIYgKFgfpELGGVGCGVATAIVYWVMFLA-MLIYIKRAR-RFRDFRLFKGLYKPDWAVIKR-----LLKL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 243 ---ICILVFFN---------MMARtgskLGADVLAANAILMQVTFIVsYMFD-GIANASSVFAGKAVGQKNPSmLDRVLR 309
Cdd:PRK01766 245 glpIGLAIFFEvslfavvtlLVSP----LGTVTVAAHQIALNFSSLL-FMLPlSLAMALTIRVGFELGAGRTL-DARQYA 318
|
330 340 350
....*....|....*....|....*....|....*...
gi 1327307398 310 LNFQWTASFIAVLT-FLTLVFKDSIVFLFTDIPTLVAL 346
Cdd:PRK01766 319 YIGLAVGLGMALLTaIFLVLFREQIALLYTDDPEVVAL 356
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
67-345 |
4.88e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 48.75 E-value: 4.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 67 TGQSAM---ALGKGNRSD----LAGSLMRPFVLSGLVGLIFILIQPLIWQgamWVIEPEAKVAEhAHIYFSILIYGAPFV 139
Cdd:cd13145 66 TGTTALignALGAGDRRKarryAAQGLSFGIILAILLTVIGLFAAPPLFR---LLGAEGDYLDL-ALEYMDVIFAGSIFF 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 140 LLNYTIIGWLMGQAKAKEVLYTQVFGNVLNIVLDAVFV----LYFDLGVAGVAYASLIAQVTTFAIGMTLVIKTSNIS-- 213
Cdd:cd13145 142 LLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIfgggGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISgc 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 214 -ISEFLQGSKMTKKDLSTIISSNTDLLLRTICILVffnmMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFA 292
Cdd:cd13145 222 rLRDFIPRLDVYKEILKQGFPASLNMMTIGLGIFV----ITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIA 297
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1327307398 293 GKAVGQKNPSMLDRVLRLNFQWTASFIAVLTFLTLVFKDSIVFLFTDIPTLVA 345
Cdd:cd13145 298 GQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIA 350
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
82-339 |
1.04e-05 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 47.68 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 82 LAGSLMRPFVLSGLVGLIFILIQP--LIWQGAmwviepEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVL 159
Cdd:PRK09575 92 LTTGLLLLLLLGPIVSVILFLFADdfLRAQGA------EGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLAT 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 160 YTQVFGNVLNIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGMTLVIKT-SNISISE-FLQGSKMTKKDLSTIISSNTD 237
Cdd:PRK09575 166 GLMVIGALINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSrANIRLTLkELRFNWSLAPKIVLLGSSSFF 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 238 LLLRTICILVFFN-MMARTGSKLgadVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTA 316
Cdd:PRK09575 246 MYLYGSFVVALHNrLFMEYGSAL---TVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTV 322
|
250 260
....*....|....*....|...
gi 1327307398 317 SFIAVLTFLTLVFKDSIVFLFTD 339
Cdd:PRK09575 323 LAGIAWVLLLNLFPETMIALFNS 345
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
9-201 |
6.78e-05 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 44.94 E-value: 6.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:COG2244 176 LKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRK 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAehAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVL 168
Cdd:COG2244 256 ALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVL 333
|
170 180 190
....*....|....*....|....*....|...
gi 1327307398 169 NIVLDAVFVLYFdlGVAGVAYASLIAQVTTFAI 201
Cdd:COG2244 334 NLVLNLLLIPRY--GLVGAAIATLLSYLVLLLL 364
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
9-207 |
8.72e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 44.62 E-value: 8.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:cd12082 222 LRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWV 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVL 168
Cdd:cd12082 302 ALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWV 381
|
170 180 190
....*....|....*....|....*....|....*....
gi 1327307398 169 NIVLDAVFVLYFDLGVAGVAYASLIAQVTTFAIGMTLVI 207
Cdd:cd12082 382 VRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-346 |
2.96e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 43.06 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFfrvsTTGQSAM---ALGKGNRSDLAGS 85
Cdd:cd13149 12 IKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGL----GIGASAVisrAIGAGDRNKAKRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 86 LMRPFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFG 165
Cdd:cd13149 88 ATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 166 NVLNIVLDAVFVLYF----DLGVAGVAYASLIAQVTTFAIGMTLVIKTSNIsISEFLQGSKMTKKDLSTIISSNTDLLLR 241
Cdd:cd13149 168 ALVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAALYFLHYHHRL-IDFSEPSLKALFRSWKDILSIGIPAALS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 242 TICILVFFNMMARTGSKLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPSMLDRVLRLNFQWTASFIAV 321
Cdd:cd13149 247 NILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYGAI 326
|
330 340
....*....|....*....|....*
gi 1327307398 322 LTFLTLVFKDSIVFLFTDIPTLVAL 346
Cdd:cd13149 327 LGIVLALFAGWLASLFSAEPEVIEL 351
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
4-207 |
6.83e-03 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 38.68 E-value: 6.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 4 THKDYLKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKgNRSDLA 83
Cdd:cd13128 204 LAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKN-DKDELK 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 84 GSLMRPFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAehAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQV 163
Cdd:cd13128 283 KLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP--AALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILL 360
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1327307398 164 FGNVLNIVLDAVFVLYFdlGVAGVAYASLIAQVTTFAIGMTLVI 207
Cdd:cd13128 361 IGALLNVILNLLLIPKY--GIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-422 |
7.92e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 38.41 E-value: 7.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 9 LKIAFPFIISTVTQPLLGAVDTAVIGQLGIAELIGGVAIGTIIMNTMYWLFGFFRVSTTGQSAMALGKGNRSDLAGSLMR 88
Cdd:cd13148 15 LRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGAMGGGVSSAIARALGAGDRERAEALVWH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 89 PFVLSGLVGLIFILIQPLIWQGAMWVIEPEAKVAEHAHIYFSILIYGAPFVLLNYTIIGWLMGQAKAKEVLYTQVFGNVL 168
Cdd:cd13148 95 ALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGAVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 169 NIVLDAVFVLYF----DLGVAGVAyaslIAQVTTFAIGMTLV---IKTSNISISEFLQGSKMTKKDLSTIIS----SNTD 237
Cdd:cd13148 175 QIPLSPGLILGWgplpRLGVAGAA----VAAVLYYALAALVLlryLASGRSRLRLRLRALRLERRLFRDILRvgllAALS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 238 LLLRTICILVFFNMMARtgskLGADVLAANAILMQVTFIVSYMFDGIANASSVFAGKAVGQKNPsmlDRVLRLNfqWTAS 317
Cdd:cd13148 251 PLQTNLTVLLLTGLVGR----FGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQI---ARARRIA--WTGA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327307398 318 FIA-----VLTFLTLVFKDSIVFLFTDIPTLVALYQEMAPWLIVFPLVSGFGLTVYgiFTGTGTTRPVRDSSIATL-LVF 391
Cdd:cd13148 322 LMAavlagAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLGLALY--FASQGAGRMLWPVLAGTLrLLI 399
|
410 420 430
....*....|....*....|....*....|.
gi 1327307398 392 LAVQALSIDMWGNHGLWlafTLFYLGRIAFL 422
Cdd:cd13148 400 AAGGGWIAVALFGAGLA---GLFAAAAAAMV 427
|
|
| |
