|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
6-388 |
1.15e-100 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 304.19 E-value: 1.15e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 6 FPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGL 85
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 86 GLLLTSISTESSMLYVSLGALVGLGLSATSYVIVLGAVAKVvPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQS 165
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWW-FERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 166 AMQVFGVLCCFMISFALFM----RAPRSTTNKQVEDNQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLAD 241
Cdd:cd17355 160 ALLVLALLALLVLVPVLLLlrrrPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 242 KNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPL 321
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1327358506 322 TSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHLPI 388
Cdd:cd17355 320 TAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-386 |
1.41e-49 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 171.99 E-value: 1.41e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 8 LLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGL 87
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 88 LLTSISTESSMLYVsLGALVGLGLsATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAM 167
Cdd:COG2223 85 LLLALAVSYWLLLL-LGLLLGIGG-GGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 168 QVFGVLCCFM-ISFALFMRAPrstTNKQVEDNQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADK-NLP 245
Cdd:COG2223 163 LILGILLLVVaVLAWLFLRDP---PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 246 ASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGL 325
Cdd:COG2223 240 AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFAL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1327358506 326 VRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHL 386
Cdd:COG2223 320 VPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
9-384 |
7.43e-35 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 132.35 E-value: 7.43e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 9 LVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLL 88
Cdd:cd17353 4 LVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 89 LTSISTESSMLYVSLGALVGLGLSATsYVIVLGAVAKVVPaEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQ 168
Cdd:cd17353 84 LSAFAISLPLLFLGYGVLGGIGAGIG-YITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 169 VFGVL-CCFMISFALFMRAPR-------STTNKQVEDNQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLA 240
Cdd:cd17353 162 ILGIIfLIIIVIGAFLIRDPPkgwvppgVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 241 DKN-LPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTV 319
Cdd:cd17353 242 EFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1327358506 320 PLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALI 384
Cdd:cd17353 322 ALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALA 386
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-386 |
3.98e-32 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 124.83 E-value: 3.98e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 16 TLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTE 95
Cdd:cd17314 11 LSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 96 SSMLYVSLGALVGLGLSATsYVIVLGAVAKVVPaEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCC 175
Cdd:cd17314 91 SFPLSYACFVFIGAGTGIL-YGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 176 FMISFALFMRA---PRSTTNKQVEDNQTlkEALSEAFANKSYWLIHA---GFFVCGFHVMFIATHLPSYLADKNLPASSA 249
Cdd:cd17314 169 IVLSVVSLLGFkepPDNQARLHVQKKKT--QTMGEIFRDKVFWILFIaifLVLIGGFLFIANMASLVRSLQLDAPSFVTK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 250 AMALAyvGIFNIFGSYFWGVMGDKFSKRHVM-SALYLVRTVVIGAFVT-LPVTESTAAIFGAAIGFCWLGTVPLTSGLVR 327
Cdd:cd17314 247 LMSIY--GLFNAFGRLLWGIVADFFGGRLSTlSILLTILGLGLCAFLFlLKMTPVGLVLTGSLLGFSYGGLFTVYPATVS 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1327358506 328 QIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHL 386
Cdd:cd17314 325 TVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-388 |
4.18e-32 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 124.60 E-value: 4.18e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 4 FRFPLLVWLGIGTLIISLgIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAY 83
Cdd:COG2271 7 YRWRILALLFLAYFLNYL-DRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 84 GLGLLLTSISTESSMLYVSLgALVGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDW 163
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLR-FLLGLGEAGF-FPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 164 QSAMQVFGVLCCFMISFALfmraprsttnkqvednqtlkealseafanksyWLIHAGFFVCGFHVMFIATHLPSYLAD-K 242
Cdd:COG2271 164 RAAFLILGLPGLLLALLRF--------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEvR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 243 NLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRH--VMSALYLVRTVVIGAFVTLPvTESTAAIFGAAIGFCWLGTVP 320
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFG 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1327358506 321 LTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsYEPIWWSTVVLAFAAALIHLPI 388
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLL 357
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
16-388 |
2.05e-31 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 122.66 E-value: 2.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 16 TLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTE 95
Cdd:cd17352 11 VNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 96 SSMLYVSLGALVGLGLS---ATSYVIVLGAVAKvvpaeHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGV 172
Cdd:cd17352 91 LWQLYLTYGVLGGLGLGliySPAIVIVGQYFEK-----KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 173 LCCFMISFALFMRaprsttnkqvednqtlkealseAFANKSYWLIHAG--FFVCGFHVMFIatHLPSYLADKNLPASSAA 250
Cdd:cd17352 166 LCLNLCVCGLLLR----------------------LLKDPTFVLLALGvsFAMLGFFVPFV--YLPSYAKSLGIDESDAA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 251 MALAYVGIFNIFGSYFWGVMGDK--FSKRHVMSALYLVRTVVIGAFvTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQ 328
Cdd:cd17352 222 FLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAF-PLATTYVGLIVFSVLFGFCSGSYSSLTPVILAD 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 329 IFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHLPI 388
Cdd:cd17352 301 LVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
10-384 |
3.44e-30 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 119.98 E-value: 3.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 10 VWLGIGTLIISLGIR---QSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:COG2807 17 WLLLLAIVLVALNLRpaiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 87 LLLTSISTESSMLYVSlGALVGLGLsATSYVIVLGAVAKVVPaEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSA 166
Cdd:COG2807 97 LLLRSLAPSVALLLAG-TALIGAGI-AVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 167 MQVFGVLCCF-MISFALFMRAPRSTTNKQVEdnqtlKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLP 245
Cdd:COG2807 174 LAVWALLALLaLLLWLPLLRRRPAAAAAAPA-----AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 246 ASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVrtVVIGAFVTLPVTESTAAIFGAA-IGFCWLGTVPLTSG 324
Cdd:COG2807 249 AATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGL--LGLAGLLGLLLAPGSLPWLWAVlLGLGQGGLFPLALT 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1327358506 325 LVRQIFG-ARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALI 384
Cdd:COG2807 327 LIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-350 |
5.78e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 112.76 E-value: 5.78e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 4 FRFPLLVWLGIGTLIISLGIrQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAY 83
Cdd:COG2814 7 RRWLALLALALGAFLSGLGI-GIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 84 GLGLLLTSISTESSMLYVsLGALVGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDW 163
Cdd:COG2814 86 ALGSLLCALAPSLWLLLA-ARFLQGLG-AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 164 QSAMQVFGVLCCFMIsFALFMRAPRSTTNKQvednQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADK- 242
Cdd:COG2814 164 RWVFLVNAVLALLAL-LLLLRLLPESRPAAR----ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVl 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 243 NLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTeSTAAIFGAAIGFCWLGTVPLT 322
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL-WLLLLALFLLGFGFGLLFPLL 317
|
330 340
....*....|....*....|....*...
gi 1327358506 323 SGLVRQIFGARYLSTLYGLVFFTHQVGS 350
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-354 |
1.99e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 97.10 E-value: 1.99e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 12 LGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTS 91
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 92 ISTESSMLYVsLGALVGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFG 171
Cdd:pfam07690 81 FASSLWLLLV-LRVLQGLGAGAL-FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 172 VLCCFMISFALFMR--APRSTTNKQVEDNQTLKEALSEAFANKSYWLIhAGFFVCGFHVMFIATHLPSYLADKNLPASSA 249
Cdd:pfam07690 159 ILSLLAAVLLLLPRppPESKRPKPAEEARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQEVLGLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 250 AMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAA--IGFCWLGTVPLTSGLVR 327
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALllLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 1327358506 328 QIFGARYLSTLYGLVFFTHQVGSFLGA 354
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0111 |
TIGR00890 |
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ... |
7-388 |
8.72e-22 |
|
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273323 [Multi-domain] Cd Length: 377 Bit Score: 95.98 E-value: 8.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 7 PLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:TIGR00890 2 WWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 87 LLLTSISTESSMLYVSLGaLVGLGLSATsYVIVLGAVAKVVPaEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSA 166
Cdd:TIGR00890 82 FTFYAIADSLAALYLTYG-LASAGVGIA-YGIALNTAVKWFP-DKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 167 MQVFGVLCCFMISF-ALFMRAPRSTTNKQVEDNQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLP 245
Cdd:TIGR00890 159 FIYMGIIFLLVIVLgAFLIGYPPGQLIKTNIEVSVKDYTVWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSLGLS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 246 ASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFG-AAIGFCWLGTVPLTSG 324
Cdd:TIGR00890 239 DGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIPMLNDVLFLATvALVFFTWGGTISLFPS 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1327358506 325 LVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsyepiWWSTVVLAFAAALIHLPI 388
Cdd:TIGR00890 319 LVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTEIG-----FEYTFIVTGAFALTSLAL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
46-386 |
9.88e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.64 E-value: 9.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 46 SFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALVGLGLSATSyVIVLGAVAK 125
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVW-PAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 126 VVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFMISFALFM-RAPRSTTNKQVEDNQTLKEA 204
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLlPEPRPPPNKRAVSAARLRSG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 205 LSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADK-NLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSAL 283
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 284 YLVrTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDY 363
Cdd:cd17325 272 LLL-SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
330 340
....*....|....*....|...
gi 1327358506 364 YGSYEPIWWSTVVLAFAAALIHL 386
Cdd:cd17325 351 FGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-384 |
8.48e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.18 E-value: 8.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 23 IRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVS 102
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 103 LgALVGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFMISFAL 182
Cdd:cd06174 91 R-FLLGLG-SGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 183 FMRAPRSTTNKQVEDNQTLKEA-----LSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADK-NLPASSAAMALAYV 256
Cdd:cd06174 169 LLLVVPDPPESARAKNEEASSKsvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 257 GIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLS 336
Cdd:cd06174 249 GLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1327358506 337 TLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALI 384
Cdd:cd06174 329 TAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
33-386 |
4.85e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 78.75 E-value: 4.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 33 PISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALVGLGLS 112
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL-ARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 113 ATSYVIVlGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVL-CCFMISFALFMRAPRSTT 191
Cdd:cd17324 103 GFWAIAA-AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLaLLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 192 NKqvedNQTLKEALSEAFANKSYWLIH-AGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVM 270
Cdd:cd17324 182 PG----SLGLLSSLLLLLRNPRLRLAYlITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 271 GDKFSKRHVMSALYLVrtVVIGAFVTLPVTESTAAIFGAAI-GFCWLGTVPLTSGLVRQIfGARYLSTLYGLVFFTHQVG 349
Cdd:cd17324 258 ADRGGRRALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLG 334
|
330 340 350
....*....|....*....|....*....|....*..
gi 1327358506 350 SFLGAWVGGRIYDYYGsYEPIWWSTVVLAFAAALIHL 386
Cdd:cd17324 335 GALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
5-388 |
7.08e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 78.38 E-value: 7.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 5 RFPLLVWLGIGTlIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:cd17319 1 RWRIIPLLFLAY-VINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 85 LGLLLTSISTESSMLYVsLGALVGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQ 164
Cdd:cd17319 80 LFTALTGFATSLTSLYV-LRFLLGVA-EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 165 SAMQVFGVLCCFMISFALFMRaprsttnkqvednqtlkealseafanKSYWLIHAGFFVCGFHVMFIATHLPSYLAD-KN 243
Cdd:cd17319 158 WAFIIEGLLGLLLAVLWWFYL--------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQaRG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 244 LPASSAAMALAYVGIFNIFGSYFWGVMGDKF---SKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAiGFCWLGTVP 320
Cdd:cd17319 212 FSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA-GFGIGAASP 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1327358506 321 LTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHLPI 388
Cdd:cd17319 291 VFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
19-367 |
3.31e-14 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 73.58 E-value: 3.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 19 ISLGIRQSFGIFMMPISEHF--GTGREFF--SFAIALQNLLfgvfQPFVGMAADKWGARRIIIAGACAYGLGLLLTSIST 94
Cdd:cd17423 14 LVFGVLRSFGVFFVEFVEYFeeSAQRVSWitSIGLAVQQLA----SPVGSALSTRYGARPVVMLGGLLSSLGFLLASFAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 95 ESSMLYVSLGALVGLGLsATSYVIVLGAVAKVVPAEHAAkAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLC 174
Cdd:cd17423 90 SLLHLYLCIGLLSGLGW-ALVFAPTMATVSRYFSRRRSL-ATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 175 CFMISFALFMRaPRSTTNKQVEDNQTLKEALSEAFanksywLIHAGFFVCGFHVMFIAT-------HLPSYLADKNLPAS 247
Cdd:cd17423 168 LHLVPCGALLR-PLALPGDPPAPPRSLSAAFGLSL------LTHRAFLRYALATTLINTgyfipyvHLVAHARALGLGEY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 248 SAAMALAYVGIFNIFGSYFWGVMGDKFSKRhVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAI--GFCWLGTVPLTSGL 325
Cdd:cd17423 241 QAAFVVSVAAVADAVGRLFSGWLADLGPLR-LLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVayGFCAGALAPLVFSV 319
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1327358506 326 VRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSY 367
Cdd:cd17423 320 LPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDY 361
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
4-365 |
1.86e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 71.47 E-value: 1.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 4 FRFPLLVWLGIGTLIISLGIrQSFGIFMMPI-SEHFGTGREFFSFAIALQNLLFGVFQPFVGMAAD----KWGARR-III 77
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAF-GLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRpWIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 78 AGACAYGLGLLLTSISTESSMLYVSLGALVGLGLSATSYVIV------LGAVAKVVPAEHAaKAFGLTTAAGSFGMFAVI 151
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVnipysaLGAELTPDYEERT-RLSSWRFAFAGLGGLLAS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 152 PGAQYMLNEFDWQSAMQVFGVLCCFMISFALFMRAPRSTT---NKQVEDNQTLKEALSEAFANKSYWLIHAGFFVCGFHV 228
Cdd:COG2211 165 VLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTkerPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 229 MFIATHLPSYLADK-NLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIF 307
Cdd:COG2211 245 ALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLV 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1327358506 308 GAAI-GFCWLGTVPLTSGLV-------RQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYG 365
Cdd:COG2211 325 LAALaGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
18-368 |
3.59e-12 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 67.16 E-value: 3.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 18 IISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESS 97
Cdd:cd17421 13 VLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGFLISIFATSVP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 98 MLYVSLGALVGLGLSatsyviVLGAVAKVVPAEHAAKAFGLTTAAGSFGM---FAVIPGAQYMLNEFDWQSAMQVFGVLC 174
Cdd:cd17421 93 FLYVSMGLLVGLGFA------FLYQAAAVMTAKYFKKRLATAYAIARSGMgltFALAPFTQLLLDEYDWQGALLIFGGIM 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 175 CFMISFALFMRAPrsttnkqveDNQTLKEALSEAFaNKSYWLIHAGFFVCGFHVMFIATHLpsyladkNLPASSAAMALA 254
Cdd:cd17421 167 LNLVASGMLLRPI---------DFSLLKDPFFCIY-TWSFVFSQLAYFIPYFHLVARARTL-------GIDPMDASFIIS 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 255 YVGIFNIFGSYFWGVMGDK-FSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGAR 333
Cdd:cd17421 230 VAGITETVAQLASGWIADQnWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDLVGVT 309
|
330 340 350
....*....|....*....|....*....|....*
gi 1327358506 334 YLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYE 368
Cdd:cd17421 310 KVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYD 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
58-384 |
1.31e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 65.34 E-value: 1.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 58 VFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALVGLGLS----ATSYvivlgAVAKVVPAEHAA 133
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYGsvqpGGGR-----AIMRWFPPRERG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 134 KAFGLTTAAGSFGMF---AVIPgaqYMLNEFDWQSAMQVFGVLCCFM-ISFALFMRAPRsTTNKQVEDNQTLKEALSEAF 209
Cdd:cd17475 120 LAMGIRQTGVPLGGAlaaALLP---PLALHYGWRAAFVVAGLVSILAaVLFWLFYREPP-AASAATESASTLLRSLKEVL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 210 ANKSYWLIH-AGFFVCGFHvMFIATHLPSYLADK-NLPASSAAMALAYVGIFNIFGSYFWGVMGDKF---SKRHVMSALY 284
Cdd:cd17475 196 RNRDVWLIAiAGALLVAPQ-FALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfggRRRPVLVITA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 285 LVRTVVIGAFVTLPVTESTAAIFG--AAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYD 362
Cdd:cd17475 275 AIAAAALLVLSLLSPGTPLWLLVLllILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVD 354
|
330 340
....*....|....*....|..
gi 1327358506 363 YYGSYEPIWWSTVVLAFAAALI 384
Cdd:cd17475 355 ATHSYAPAWLALALLLVLAALL 376
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-384 |
2.11e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.88 E-value: 2.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 1 MSIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGA 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 81 CAYGLGLLLTSISTESSMLyvsLGALVGLGLSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFG-MFAVIPGAQYMLN 159
Cdd:COG0738 81 LLMALGLLLFALAPSYPLL---LLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGaLLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 160 EFDWQSAMQVFGVLCCFMISFALFMRAPRSTTNKQVEDNQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYL 239
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 240 AD-KNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPvTESTAAIFGAAIGFCWLGT 318
Cdd:COG0738 238 KDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP-GPWLALIGLALVGLGLSLM 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1327358506 319 VPLTSGLVRQIFGaRYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsyepIWWSTVVLAFAAALI 384
Cdd:COG0738 317 FPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG----LRAAFLVPLVCYLLI 377
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
18-368 |
5.80e-11 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 63.31 E-value: 5.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 18 IISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESS 97
Cdd:cd17429 13 ILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 98 MLYVSLGALVGLGlSATSYVIVLGAVAKVVPAEHAAkAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVlccfm 177
Cdd:cd17429 93 YLFISFGVTAGIG-SGMAYLPAVVMVGQYFQKRRAL-AQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQGA----- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 178 isfalfmraprsttnkqVEDNQTLKEALSEAFANKSY--WLIHAGFFVCGFHVMFIatHLPSYLADKNLPASSAAMAL-A 254
Cdd:cd17429 166 -----------------VSLNLCVCGALMRLFTNKVFvaFIFWALFAYCSFVIPFI--HLPEIVKLYGLSEQNDKFPLtS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 255 YVGIFNIFGSYFWGVMGDkFSKRHVMSALYLVRTVVIGAFVTLPV--TESTAAIFGAAIGFCwLGTVPLTSGLVRQIFGA 332
Cdd:cd17429 227 IIAIVHIFGKVILGIICD-LPCISVWNVFILANFTLGVCILILPLmhTYTGLAIVCALIGFS-SGYFSLMPVVTEDLVGI 304
|
330 340 350
....*....|....*....|....*....|....*.
gi 1327358506 333 RYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYE 368
Cdd:cd17429 305 KNLANAYGIIICANGISALLGPPFAGWIYDITQKYD 340
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
11-383 |
2.40e-10 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 62.07 E-value: 2.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 11 WLGIGTLIISLGIRQSF----GIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:TIGR00892 18 WVVLGATFVSIGFSYAFpkavTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 87 LLLTSISTESSMLYVSLGALVGLGL--SATSYVIVLGA--VAKVVPAEhaakafGLTTAAGSFGMFAVIPGAQYMLNEFD 162
Cdd:TIGR00892 98 MILASFSSNVIELYLTAGFITGLGLafNFQPSLTMLGKyfYRRRPLAN------GLAMAGSPVFLSTLAPLNQYLFESFG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 163 WQSAMQVFGVL---CCfmISFALfMR---------APRSTTNKQVEDNQTLKEALSEAFANKSYW----LIHAGFFV--C 224
Cdd:TIGR00892 172 WRGSFLILGGLllhCC--VCGAL-MRpvgpsqrvsKSKSKEGLPPDGSTKKLSKKSTAEKINRFLdfslFTHRGFLVylS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 225 GFHVMFIATHLP-----SYLADKNLPASSAAMALAYVGIFNIFGSYFWGVM-GDKFSKRHV--MSALYLVRTVVIGAFVT 296
Cdd:TIGR00892 249 GNVIMFLGFFAPiiflvPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIaGLKWIRPHVqyLFSFALLFNGLTHLLCA 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 297 LPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVV 376
Cdd:TIGR00892 329 LAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGS 408
|
....*..
gi 1327358506 377 LAFAAAL 383
Cdd:TIGR00892 409 IVVSAGL 415
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
69-384 |
5.07e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 60.40 E-value: 5.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 69 KWGARRIIIAGACAYGLGLLLTSISTeSSMLYVSLGALVGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMF 148
Cdd:cd06180 60 RGRARRLIRGGLLLTVLLLAAMALTS-GFAALLALRFLAGAA-SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 149 ----AVIPGAQYMLNefdWQSAMQVFGVL--CCFMISFALFMRAPRsttnkqveDNQTLKEALSEAFANKSYWLIHAGFF 222
Cdd:cd06180 138 lsglLVPAGLGGGLS---WRAGWLALALLsaVLLLLSFLLLRRGPS--------APTEASAAESAPGLNRPLWRLALAYG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 223 VCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPvTES 302
Cdd:cd06180 207 LFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSP-GPA 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 303 TAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLyGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAA 382
Cdd:cd06180 286 GLVLSAVLFGGTFMAITALVMALARELAPPAAPRAL-ALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAA 364
|
..
gi 1327358506 383 LI 384
Cdd:cd06180 365 LL 366
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-386 |
1.31e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 34 ISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLyVSLGALVGLGLSA 113
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 114 TSyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMfAVIPGAQYMLNEFDWQSAMQVFGVLCcfMISFALFMRAPRSTTNK 193
Cdd:cd17474 104 LG-PLALTLIGDLFEGGERAKAMGLYEAALGLGI-AVGPLLGGLLAAISWRYPFFLLAALI--PVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 194 QVEDNQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADK-NLPASSAAMALAYVGIFNIFGSYFWG-VMG 271
Cdd:cd17474 180 AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGrLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 272 DKFSKRHVM---SALYLVRTVVIGAFVTLPVTESTAAIFGAAIGfcwlGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQV 348
Cdd:cd17474 260 KRFGARRILvigLLLYALSLLLLGFVPSLALLLIAIVLFGLGLG----LNLPLLTTLVTELAPEEERGTASSLYNFVRFL 335
|
330 340 350
....*....|....*....|....*....|....*...
gi 1327358506 349 GSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHL 386
Cdd:cd17474 336 GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
18-367 |
2.80e-09 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 58.28 E-value: 2.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 18 IISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESS 97
Cdd:cd17424 13 VCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 98 MLYVSLGALVGLGLsATSYVIVLGAVAKVVpAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFM 177
Cdd:cd17424 93 YLYLTLGVLTGLGF-ALCYSPAIAMVGKYF-HKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 178 ISFALFMRaprsttnkqvednqtlkealseafanksyWLIHAGFFVCGFHVMFIA-------THLPSYLADKNLPASSAA 250
Cdd:cd17424 171 CVCGALMR-----------------------------FLLMPDFLVLAVSVLFLAygcsppfVYLVPYALSVGVSHQQAA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 251 MALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIG-AFVTLPVTESTAAI--FGAAIGFCWLGTVPLTSGLVR 327
Cdd:cd17424 222 FLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGlCCLFLPILKTFPLLvpFSFTFGYFDGAYVALIPVVTS 301
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1327358506 328 QIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSY 367
Cdd:cd17424 302 DVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTY 341
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
45-358 |
2.83e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 58.52 E-value: 2.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 45 FSFAIALQNLLFGVFqpFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALVGLGLSATsYVIVLGAVA 124
Cdd:TIGR00895 56 FLFSAGLIGMAFGAL--FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI-LRFLAGLGLGGL-MPNLNALVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 125 KVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFMISFALF--------------------- 183
Cdd:TIGR00895 132 EYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRflpesidflvskrpetvrriv 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 184 -------MRAPRSTTNKQVEDNQTLKEALSEAFA---NKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLPASSAAMAL 253
Cdd:TIGR00895 212 naiapqmQAEAQSALPEQKSTQGTKRSVFKALFQgktARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 254 AYVGIFNIFGSYFWGVMGDKFSKRHVMSALYL--VRTVVIGAFVTLPvteSTAAIFGAAIGFCWLGTVPLTSGLVRQIFG 331
Cdd:TIGR00895 292 ALFNFGGVIGSIIFGWLADRLGPRVTALLLLLgaVFAVLVGSTLFSP---TLLLLLGAIAGFFVNGGQSGLYALMALFYP 368
|
330 340
....*....|....*....|....*..
gi 1327358506 332 ARYLSTLYGLVFFTHQVGSFLGAWVGG 358
Cdd:TIGR00895 369 TAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
34-311 |
4.03e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.97 E-value: 4.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 34 ISEHFGTGREFF-SFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALVGLGLS 112
Cdd:cd17473 25 IAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR-ALLGIGVA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 113 ATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFG--MFAVIPGAqymLNEFDWQSAMQVFGVLCCFMISFALFMRAPRst 190
Cdd:cd17473 104 GI-MTLATALIGDYFEGEERAKMLGLQSAAMSLGgvVFLLLGGA---LAEIGWRAPFLVYLLALPVLILVLLFLPEPA-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 191 tNKQVEDNQTLKEALsEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNL-PASSAAMALAYVGIFNIFGSYFWGV 269
Cdd:cd17473 178 -RKSKSAASPGAATA-AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGR 255
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1327358506 270 MGDKFSKRHVMSALYLvrtVVIGAFVTLPVTESTAAIFGAAI 311
Cdd:cd17473 256 LKRRLGKRRLLAIGFA---LMALGFLLLALASGLWVVLLGAI 294
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
47-384 |
4.72e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.60 E-value: 4.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 47 FAIALQNLLFGVFqpFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLyVSLGALVGLGLSAtsyvivLGAVAKV 126
Cdd:cd17365 40 GSAALFGMAIGAL--LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL-ALLRFLTGLGLGA------AMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 127 VPAEHAAK---AFGLTTAAGSFGMFAVIPG--AQYMLNEFDWQSAMQVFGVLccfMISFALFMRAprsttnkqvednqTL 201
Cdd:cd17365 111 LVSEYAPArrrSLAVTLMFCGYPLGAALGGflAAALIPAFGWRSVFLLGGVP---PLILLPLLRG-------------TL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 202 kealseafanksywLIHAGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMS 281
Cdd:cd17365 175 --------------LLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 282 ALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIY 361
Cdd:cd17365 241 LFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLL 320
|
330 340
....*....|....*....|...
gi 1327358506 362 DYYGSYEpiwwsTVVLAFAAALI 384
Cdd:cd17365 321 AAGLGPE-----SVFLALAIPAA 338
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
61-384 |
5.35e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.18 E-value: 5.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 61 PFVGMAADKWGARRIIIAGACAYGLGLLLTSISTeSSMLYVSLGALVGLGLsATSYVIVLGAVAKVVPAEHAAKAFGLTT 140
Cdd:cd17477 49 PLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD-SPWVWFLLRFVMGIGL-AGLFVVSESWLNALATNENRGRVLGLYS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 141 AAGSFGMFAvipgAQYMLNEFDWQSAMQVFGVLCCFMISFALFMRAPRSTTNKQVEDNQTLKEALSEAfanksyWLIHAG 220
Cdd:cd17477 127 TVLGLGFAL----GPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIA------PLALLG 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 221 FFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVT 300
Cdd:cd17477 197 AFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 301 ESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFA 380
Cdd:cd17477 277 PLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLF 356
|
....
gi 1327358506 381 AALI 384
Cdd:cd17477 357 LLFL 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
47-384 |
8.46e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.83 E-value: 8.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 47 FAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALVGLGLSATSYVIVLGaVAKV 126
Cdd:cd17489 35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLR-LIHGIGWGAFTTAAATL-VADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 127 VPAEHAAKAFGLTTAAGSFGM--FAVIPGAQYMLNEFDWqsamqvFGVLCCFMISFALFMRAPRSTTNKQVEDNQTLKEA 204
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMalGPALGLFLYQHLGFAV------LFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 205 LSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLpaSSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALY 284
Cdd:cd17489 187 AFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI--SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 285 LVRT---VVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVffthQVGSFLGAWVGGRIY 361
Cdd:cd17489 265 LLLAlglLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFF----DLGIGLGGLLLGLVA 340
|
330 340
....*....|....*....|...
gi 1327358506 362 DYYGsYEPIWWSTVVLAFAAALI 384
Cdd:cd17489 341 ELFG-YRAMFLLAAVVVLLALVL 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-188 |
1.57e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.04 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 5 RFPLLVWLGIGTLIISLGIRQSFGIFMMpisEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:COG2223 206 RFWLLSLLYFGTFGSFIGFSSWLPPYLV---DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 85 LGLLLTSISTESSMLYVSLGALVGLGLSATSyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEF-DW 163
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGN-GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSY 361
|
170 180
....*....|....*....|....*
gi 1327358506 164 QSAMQVFGVLCCFMISFALFMRAPR 188
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-185 |
1.81e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 3 IFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACA 82
Cdd:cd17325 195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 83 YGLGLLLTSISTESSMLYVSLgALVGLGLSATSyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFD 162
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLL-ALLGLGLGLVF-PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
170 180
....*....|....*....|...
gi 1327358506 163 WQSAMQVFGVLCCFMISFALFMR 185
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-384 |
1.07e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 53.33 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 46 SFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALVGLGLSAtsYVIVLGAVAK 125
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAA--FHPEGARLAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 126 VVPAEHAAKAFGLTTAAGSFGmFAVIPGAQYMLNEFDWQSAMQVFGVLcCFMISFALFMRAPRSTTNKQVEDNQTLKEAL 205
Cdd:cd17478 111 QAAGGRRGLAMSIFSVGGNLG-FALGPLIAAALVALFGGLGLLILLII-PGLAVALLLLRLRPLKKPEAKKAAAKSSARS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 206 SEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYL 285
Cdd:cd17478 189 TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 286 VRTVVIGAFVTLPVTESTAAIFgaAIGFCWLGTVPLTSGLVRQIFgARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYG 365
Cdd:cd17478 269 LAAPFLLLFLLTPGIWSYILLV--LAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFG 345
|
330
....*....|....*....
gi 1327358506 366 SYEPIWWSTVVLAFAAALI 384
Cdd:cd17478 346 LESVLLILALLPLLGALLA 364
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
61-383 |
3.70e-07 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 51.80 E-value: 3.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 61 PFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALVGLGLsATSYVIVLGAVAKVVPAEHAAkAFGLTT 140
Cdd:cd17426 56 PISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGL-AFNLNPALTMIGKYFYKKRPL-ANGLAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 141 AAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVL---CCFMISFAlfmrapRSTTNKQVEDnqtlkealSEAFANKSYWLI 217
Cdd:cd17426 134 AGSPVFLSTLAPLNQWFFDIFGWRGSFLILGGLllnCCVAGSLM------RPIGPKPFLD--------LTLFTHRGFLLY 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 218 HAGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGA---F 294
Cdd:cd17426 200 LSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVchlL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 295 VTLPVTESTAAIFGAAIGFC--WLGTVPLTSglVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWW 372
Cdd:cd17426 280 APLSTSYVGFCIYAIFFGFAfgWLSSVLFET--LMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYW 357
|
330
....*....|.
gi 1327358506 373 STVVLAFAAAL 383
Cdd:cd17426 358 ACGIVLIISSI 368
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-384 |
7.60e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 50.74 E-value: 7.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 8 LLVWLGIGTLIISlgiRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGL 87
Cdd:cd17312 6 LGVFLGYAAYYVC---RKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 88 LLTSISTESSMLYVSLGaLVGLGLSATSYVIVLGAVAKVVPAEHAAKaFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAM 167
Cdd:cd17312 83 IFMGFSTSLWFFAVLWG-LNGLFQSMGWPPCVKLLGNWFSKKERGTV-YGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 168 QVFGVLCCFMISFALFMraprsttnkQVEDNQTLKEAlseAFANKSYWLIHAGFFVCGfhVMFIATHLPSYLADknlpAS 247
Cdd:cd17312 161 LVPGIVGLVVAIILFFF---------LRDSPPYVWVL---SLAYAFVYIVRYACLDWG--PLYLYEVKGYSLID----AG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 248 SAAMALAYVGifnIFGSYFWGVMGDKF--SKRHVMSALYLV-RTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSG 324
Cdd:cd17312 223 WFSSLYEVGG---IAGTILAGLLSDKLfgGRRAPIAVIYMLlMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGG 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1327358506 325 LVRQIFGARY-LSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsyepiwWSTVVLAFAAALI 384
Cdd:cd17312 300 AAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYG------WSTVFYFLISAAL 354
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
24-365 |
1.33e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.93 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 24 RQSFGIFMMPISEHFGTGrefFSFAIALQ---NLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLY 100
Cdd:cd17328 15 RFTIAGVLPDIQSDFLID---DSLAGLLQtvfIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 101 VsLGALVGLGLSatSYVIVLGAV-AKVVPAEHAAKAFGLTTAAGSFG-MFAVIPGAQYMLNEFDWQSA---MQVFGVLCC 175
Cdd:cd17328 92 L-FRALVGIGEA--SYSPIAPTIiADLFPKEKRTRALGVFYFAIPLGsGLGYVVGGLVAQATGGWRWAfrvTGVLGVLLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 176 FMIsfALFMRAPRS----TTNKQVEDNQTLKEALSEAFANKSYWLIHAGF----FVCGFHVMFIATHLPSYLADKNLPAS 247
Cdd:cd17328 169 ILL--LLFVREPPRgaaeGGVMAKSTATSFLADLKALAKNPSFILSTLGFtavsFVTGALAFWAPTFFLRAFGVGDLSSA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 248 SAAMAL-AYVGIFNIFGSYFWGVMGDKFSKRHV-------MSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTV 319
Cdd:cd17328 247 DVGLIFgAITCIAGVLGVLLGGILADRLRRKTPradplvcAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNW 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1327358506 320 PLTSGLVRQIFGARYLSTLYGL-VFFTHQVGSFLGAWVGGRIYDYYG 365
Cdd:cd17328 327 APVFAILLYVVIPTRRSTASAIqILLSHLLGDAGSPYLIGLISDLLR 373
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-188 |
1.33e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.87 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 2 SIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPI-SEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGA 80
Cdd:COG2271 174 GLLLALLRFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 81 CAYGLGLLLTSISTESSMLYVSLGALVGLGLSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNE 160
Cdd:COG2271 254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
170 180
....*....|....*....|....*...
gi 1327358506 161 FDWQSAMQVFGVLCCFMISFALFMRAPR 188
Cdd:COG2271 334 TGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
62-317 |
2.26e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 49.22 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 62 FVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALVGLGLsATSYVIVLGAVAKVVPAEHAAKAFGLTTA 141
Cdd:cd17371 53 LGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI-LRALAGLGF-GGEWAAGAALMAEYVPARHRGKALGYVQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 142 AGSFGMFAVIPGA----QYMLNEFDWQsAMQVFGVLCCFMISF-ALFMRAPRSTTNKQVEDNQTLKEA-LSEAFANKSYW 215
Cdd:cd17371 131 GWAVGWLLATLLAallfPLLPPEIAWR-VLFLLGALPALLVLFiRRFVKEPPQWQAARAARRHFADRPsLRELFSPPLLR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 216 LIHAGFFVCGFHVM---FIATHLPSYL-ADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVI 291
Cdd:cd17371 210 TTLLASLLATGALGgyyGITTWLPSYLtGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISI 289
|
250 260
....*....|....*....|....*.
gi 1327358506 292 GAFVTLPVTESTAAIFGAAIGFCWLG 317
Cdd:cd17371 290 LLYFFLPLSPTLILILGFPLGFFASG 315
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
9-383 |
2.88e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.76 E-value: 2.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 9 LVWLGIGTLIISLGIrqSFGIFMMPI--SEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:cd17329 1 LWVLLIGSFLNRLGF--FMVWPFMAIylHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 87 LLLTSIsteSSMLYVSLGALVGLGLSATSYVIVLGA-VAKVVPAEHAAKAFGLTTAAGSFGMF--AVIPGAQYMLNeFDW 163
Cdd:cd17329 79 FALLGF---AHSPWLFAIALVLTGFGGGLFEPASEAmIADVTTPENRTRAFSLLYWAINLGVAigPLLGGLLLLYS-FRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 164 QSAMQVFGVLCCFMISFALFMRAPRSTTNKQVEDnqtLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLAD-K 242
Cdd:cd17329 155 LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTE---ILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEiL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 243 NLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVvigAFVTLPVTESTAAIFGAAIgFCWLGTV--- 319
Cdd:cd17329 232 GLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI---GFAVLAFANTLAVLILAMI-VLTLGEMlvf 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1327358506 320 PLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAAL 383
Cdd:cd17329 308 PAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
23-365 |
3.51e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.53 E-value: 3.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 23 IRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTeSSMLYVS 102
Cdd:TIGR00881 10 VRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST-SLWVMAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 103 LGALVGLgLSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEF-DWQSAMQVFGvLCCFMISFA 181
Cdd:TIGR00881 89 LWALNGI-FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPG-IIAIIVSLI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 182 LF-----------------MRAPRSTTNKQVEDNQTLKEA--LSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLAD- 241
Cdd:TIGR00881 167 CFlllrdspqscglppaeeMPNEEPDGDAEKKEEELTKKQifLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQe 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 242 KNLPASSAAMALAYVGIFNIFGSYFWGVMGDKF--SKRHVMSALY--LVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLG 317
Cdd:TIGR00881 247 KGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFmaLIIVSLLVYWLNPAANPLMDLICLFALGFLVYG 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1327358506 318 TVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYG 365
Cdd:TIGR00881 327 PQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
62-384 |
3.67e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.37 E-value: 3.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 62 FVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALVGLGLSAtSYVIVLGAVAKVVPAEHAAKAFGLTTA 141
Cdd:cd17316 55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLV-LRFLQGIGIGG-EYPGASTYVAEFAPSKRRGFALGLLQS 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 142 AGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFMISFALFMRaprsttnkqvednqtlkealseafanKSYWLIHAGF 221
Cdd:cd17316 133 GWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLR--------------------------RRTLLLILLW 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 222 FVCGFHVMFIATHLPSYL-ADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTV-VIGAFVTLPV 299
Cdd:cd17316 187 FFISFGYYGLTTFLPTYLqTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIlALPLFYLLSG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 300 TESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAF 379
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....*
gi 1327358506 380 AAALI 384
Cdd:cd17316 347 VALIV 351
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
64-386 |
7.03e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.55 E-value: 7.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 64 GMAADKWGARRIIIAGACAYGLGLLLTSISTESSM--LYVS---LGALVGLGLSATSYVIvlgavAKVVPAEHAAKAFGL 138
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLplLILSrilLGLGEGVHFPSMTSLF-----SRWVPVSERSRAVSI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 139 TTAAGSFG-MFAVIPGAqYMLNEFDWQSAMQVFGVLCcfmISFALFMRaprsttnkqvednqtlkealseaFANKSYWLI 217
Cdd:cd17380 130 VTAGSYLGtLLGGLIGP-LLLEYYGWPSVFYFFGLLG---LLWALVWL-----------------------IYLPPVWAI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 218 HAGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKF--------SKRHVMSALYLVRTV 289
Cdd:cd17380 183 IVAHFCMNWGFYILLSWLPTYFHEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLisrgwtvtSVRKLMQSIGFLGPA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 290 VIGAFVTLPVTESTAAIF-GAAIGFCWLGTVPLTSGLvrQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYE 368
Cdd:cd17380 263 LFLLLLSHTDSFSLALLCmSVALGLSAFSSSGVLVNH--QDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWS 340
|
330
....*....|....*...
gi 1327358506 369 PIWWSTVVLAFAAALIHL 386
Cdd:cd17380 341 LVFVLAAVVNLVGAVVFL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
215-384 |
7.18e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 7.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 215 WLIHAGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAF 294
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 295 VTLPvTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsYEPIWWST 374
Cdd:COG2814 93 ALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVN 170
|
170
....*....|
gi 1327358506 375 VVLAFAAALI 384
Cdd:COG2814 171 AVLALLALLL 180
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-386 |
8.31e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 8.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 45 FSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGL---GLLLTSISTESSMLYVSLGALVGLGLSATSYVIVLG 121
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALlaaVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 122 AVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFMISFALFMRAPRSTTNKQVEDNQT- 200
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLr 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 201 -LKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADK-NLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRH 278
Cdd:cd06173 196 dLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 279 VMSALYLVRTVVIGAFVTLPVTESTAAIFgAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGG 358
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAAL-FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAG 354
|
330 340
....*....|....*....|....*...
gi 1327358506 359 RIYDYYGSYEPIWWSTVVLAFAAALIHL 386
Cdd:cd06173 355 LLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
220-397 |
2.07e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.26 E-value: 2.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 220 GFFVCGFHVMFIATHLPSYLA-DKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVrTVVIGAFVTLP 298
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLL-FALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 299 VTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLA 378
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170
....*....|....*....
gi 1327358506 379 FAAALIHLPINDKPIERLK 397
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPK 181
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-188 |
2.27e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.96 E-value: 2.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 5 RFPLLVWLGIGTLIISLGIrQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:COG0477 12 RRRALLALALGTFLEGLDF-TIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 85 LGLLLTSISTESSMLYVsLGALVGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQ 164
Cdd:COG0477 91 LASLLCGLAPSPELLIA-ARALQGIGAGGL-MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180
....*....|....*....|....
gi 1327358506 165 SAMQVFGVLCCFMISFALFMRAPR 188
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESR 192
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
178-384 |
2.76e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 178 ISFALFMRAPRSTTNKQVEDNQTLKeaLSEAFANKSYW--LIHAGFFVCG-FHVMFIATHLpsyladKNLPASSAAMALA 254
Cdd:cd17370 168 LALLILLFVVKEYPRPPKLRKKSKK--TSLKKLPKAFWlyLLAVALFALGnFSFAFLILRA------QELGLSAALIPLL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 255 YVgIFNIF---GSYFWGVMGDKFSKRHVMSALYLVrtVVIGAFVTLPVTESTAAIFGAAIGFCWLGTV-PLTSGLVRQIF 330
Cdd:cd17370 240 YA-LFNLVyalAAYPAGRLSDRIGRKKLLILGYLS--LALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLV 316
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1327358506 331 GARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALI 384
Cdd:cd17370 317 PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
44-360 |
4.01e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 45.30 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 44 FFSFAIALQNLLFGVF-------QPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSM-LYVSLGALVGLGLSAT- 114
Cdd:cd17318 50 EFDWSEKTQGIILSSFfygyiltQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYgALIVLRILQGLAQGVTf 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 115 --SYVIVlgavAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVL-CCFMISFALFMRAprstt 191
Cdd:cd17318 130 paMHALW----AKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLgLLWCLLWFFLVLP----- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 192 nkqvednqtlkealseafanksYWLIHAGFFVCGFHVMFIATHLPSYLAD---KNLPASSAAMALAYVGIfnIFGSYFWG 268
Cdd:cd17318 201 ----------------------VWAIVVAHFGHNWGFYTLLTELPTYMSDvlhFNIKSNGFLSSLPYLAM--WICSIVGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 269 VMGDKFSKRHVMS----------------ALYLVRTVVIGAFVTLPVTESTAAIfgAAIGFCWLGtvPLTSGLVrqiFGA 332
Cdd:cd17318 257 YLADWLRSRGILStttvrklftsigflgpGVFLIALGYLGSNATLAVVFLTLSV--GLSGACYSG--FLVNHLD---LAP 329
|
330 340
....*....|....*....|....*...
gi 1327358506 333 RYLSTLYGLVFFTHQVGSFLGAWVGGRI 360
Cdd:cd17318 330 NYAGTLMGITNTAATIAGIISPLIVGAI 357
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
44-383 |
4.68e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.88 E-value: 4.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 44 FFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVS--LGALVGLGLSatsyvIVLG 121
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLArfLDGLTGGNVS-----VAQA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 122 AVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFMISFALFMRaprsttnkqvednqtl 201
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 202 kealseafanKSYWLIHAGFFVCGFHVMFIATHLPSYLADK-NLPASSAAMALAYVGIFNIFGSYF-WGVMGDKFSKRHV 279
Cdd:cd17330 174 ----------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRfGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 280 MSALYLVrtVVIGAFVTLPVTESTAAIFGAAI-GFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGG 358
Cdd:cd17330 244 LRLGLLL--AIIGLLLLPFASSVPLLVLAAAIlAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAG 321
|
330 340
....*....|....*....|....*
gi 1327358506 359 RIYDYYGSYEPIWWSTVVLAFAAAL 383
Cdd:cd17330 322 PLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
14-383 |
5.59e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.95 E-value: 5.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 14 IGTLIISLGIRQSFGIFMMPISEHFGTGREFFSF----AIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLL 89
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELwsglAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 90 TSISTESSMLyVSLGALVGLGLSATSYVIVLgaVAKVVPAEHAAKAFG-LTTAAGSFGMFAVIPGAqYMLNEFDWQSAMQ 168
Cdd:cd17391 83 MAFVTNVWQL-LILRLLQGVFSGYVPNATAL--IASQTPKEKSGWALGtLSTGVVAGTLIGPLLGG-FLADLFGIRNVFF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 169 VFGVL--CCFMISfALFMRAPRstTNKQVEDNQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLPA 246
Cdd:cd17391 159 ITGGLlfLAFLLT-LFFVKEDF--KPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 247 SSAA----MALAYVGIFNIFGSYFWGVMGDKFSKRHVM--SALYLVRTVVIGAFVTlpvTESTAAIFGAAIGFCWLGTVP 320
Cdd:cd17391 236 SNLAfisgLVFSATGVSSLLSAPRLGKLGDRIGHHRILlgALLASALLYIPQAFVQ---TPWQLGILRFLLGLATGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1327358506 321 LTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsYEPIWWSTVVLAFAAAL 383
Cdd:cd17391 313 AINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFG-YRAVFVVTALLVLLNAI 374
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
47-113 |
9.25e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.16 E-value: 9.25e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 47 FAIALQNLLFGVFQPFV-GMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSL--GALVGLGLSA 113
Cdd:cd17388 246 LSLAVFGLLHALFQAFVtGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILilLALGGIAGPA 315
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
34-383 |
1.58e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.33 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 34 ISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALVGLGLSA 113
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI-ARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 114 TSyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMfAVIPGA-QYMLNEFDWQS---AMQVFGVLCCFMISFALFMRAPRs 189
Cdd:cd17320 104 GS-VVARAIVRDLYSGAELAKIFSLLMMILAIAP-ALAPLLgGLLLLFFGWRAifvFLALLGLLLLLLVLLFLPETLPE- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 190 ttNKQVEDNQTLKEALSEAFANKSYW-------LIHAGFFVCGFHVMFIathlpsYLADKNLPASSAAMALAYVGIFNIF 262
Cdd:cd17320 181 --EKRKPLLSSLLRAYKRVLKNRRFLgyalalgLSFAGLFAYLAAAPFI------YIEQLGLSPAQFGLLFALNAIALIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 263 GSYFWGVMGDKFSKRHVM------SALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLS 336
Cdd:cd17320 253 GSLLNGRLVRRFGPRRLLrlglllLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTAS 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1327358506 337 TLYGLVFFthqVGSFLGAWVGGRIYDyyGSYEPIWWSTVVLAFAAAL 383
Cdd:cd17320 333 ALLGFLQF---LIGALAGALVGLLPN--GTALPMGLLILVLGLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
220-397 |
2.25e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 220 GFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFvTLPV 299
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-AFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 300 TESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDY--YGSYEPIWWSTVVL 377
Cdd:cd06174 83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALA 162
|
170 180
....*....|....*....|
gi 1327358506 378 AFAAALIHLPINDKPIERLK 397
Cdd:cd06174 163 LLAAILLLLVVPDPPESARA 182
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
11-175 |
2.58e-04 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 42.88 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 11 WLGIGTLIISLGIRQSF----GIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:cd17427 2 WAVVFGAFISIGFSYAFpkaiTVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 87 LLLTSISTESSMLYVSLGALVGLGLS---ATSYVIVLGAVAKVVPAehaakAFGLTTAAGSFGMFAVIPGAQYMLNEFDW 163
Cdd:cd17427 82 MISASFCNSVMQLYLCIGVIGGLGLAfnlQPALTIIGKYFYKKRPI-----ANGLAMAGSPVFLSTLAPLNQFLFNQFGW 156
|
170
....*....|....*
gi 1327358506 164 QSAMQVFGVL---CC 175
Cdd:cd17427 157 RGSFLILGGLllnCC 171
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
1-184 |
2.87e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.54 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 1 MSIFRFPLLVWLGIGTLIISLGIrQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGA 80
Cdd:cd17352 177 LRLLKDPTFVLLALGVSFAMLGF-FVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIF 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 81 CAYGLGLLLTSIST-ESSMLYVSLGALVGLGLSATSYVIVLgAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLN 159
Cdd:cd17352 256 TLLILGLSLLAFPLaTTYVGLIVFSVLFGFCSGSYSSLTPV-ILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRD 334
|
170 180
....*....|....*....|....*
gi 1327358506 160 EFDWQSAMQVFGVLCCFMISFALFM 184
Cdd:cd17352 335 YTGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
5-184 |
3.08e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 5 RFPLLVWLGIGTLIIsLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:cd17370 197 KLPKAFWLYLLAVAL-FALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 85 LGLLLTSISTESSMLYVSLgALVGLGLSATSyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFA--VIPGAQYmlnefD 162
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGF-ILWGLYMGAQE-SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLasLIAGYLW-----D 348
|
170 180
....*....|....*....|..
gi 1327358506 163 WQSAMQVFGVLCCFMISFALFM 184
Cdd:cd17370 349 LISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
21-365 |
4.33e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.20 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 21 LGIRQsFGIFM-MPISEHFGtgREFFSFAIALQNLLFG-------VFQ-PFvGMAADKWGARRIIIAGACAYGLGLLLTS 91
Cdd:cd17472 5 FSLRM-LGMFLvLPVLSVYA--KSLPGATPTLIGLALGiygltqaIFQiPF-GLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 92 ISTESSMLYVSLgALVGLGlsATSYViVLGAVAKVVPAEHAAKAFGLTTAagSFGMFAVI-----PGAQYMLNeFDWQSA 166
Cdd:cd17472 81 YATSIYGLILGR-ALQGSG--AISSV-VMALLADLTREENRTKAMALIGA--SIGIAFAIsmvlgPLLAAHLG-VSGLFL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 167 MQVFGVLCCFMISFALFMRAPRSTTNKQVEdnqtlKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLPA 246
Cdd:cd17472 154 ITAILSLVSLLILLFFVPDPPKIVQISEKE-----KKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGK 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 247 SSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTV-PLTSGL 325
Cdd:cd17472 229 GQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLeALLPSL 308
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1327358506 326 VRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYG 365
Cdd:cd17472 309 VSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLG 348
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-147 |
5.14e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 5.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 2 SIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGAC 81
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1327358506 82 AYGLGLLLTS-ISTESSMLYVSLGALVGLGLSATsYVIVLGAVAKVVPAEH-------AAKAFGLTTAAGSFGM 147
Cdd:COG2211 303 LAALGLLLLFfLGPGNLWLLLVLAALAGIGLGAI-LVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQ 375
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
1-147 |
5.25e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.79 E-value: 5.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 1 MSIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGV----FQPFVGMAADKWGARRII 76
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALvmliAGPLAGRLIARVGPRRVL 250
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1327358506 77 IAGACAYGLGLLLTSISTESSMLYVSLGALVGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGM 147
Cdd:cd17504 251 LIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLA-FASLPNIVVESVPPDRTGIATGMNTVLRTIGS 320
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
61-380 |
6.68e-04 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 41.64 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 61 PFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALVGLGLSAT--SYVIVLGAVAKvvpaEHAAKAFGL 138
Cdd:cd17430 56 PLCSILVNRFGCRPVMLVGGLLASLGMILASFCTSIIQLYLTAGVITGLGLALNfqPSLIMLGRYFD----KRRPLANGL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 139 TTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFMISFALFMRAPRSTTnkqvednqtlkealseaFANKSY--WL 216
Cdd:cd17430 132 AAAGSPVFLSALSPLGQILLEEYGWRGGFLILGGLLLNCCTCGAVMRPLDFSV-----------------FRDRGFviYT 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 217 IHAGFFVCGFHVMFIAthLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVM-GDKFSKRHVMsalYLVRTVVIGAFV 295
Cdd:cd17430 195 IAKFIMVLGLFVPPIF--VVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVaGLKWVRPRVV---YLFSFAMLFNGL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 296 TlPVTESTAAIFGAAIGFCWL-----GTV-PLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEP 369
Cdd:cd17430 270 T-DLCSATAADYGGLVVFCVFfgisyGMVgALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYEL 348
|
330
....*....|....*....
gi 1327358506 370 IWW--------STVVLAFA 380
Cdd:cd17430 349 IFYlagsevvlSALFLALG 367
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
16-279 |
9.49e-04 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 40.91 E-value: 9.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 16 TLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTE 95
Cdd:cd17425 11 VQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVGMVASSFSHS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 96 SSMLYVSLGALVGLGL--SATSYVIVLGAVAkvvpAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVL 173
Cdd:cd17425 91 IVQLYFTAGFITGLGFcfSFQSSVTVLGFYF----VRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFLVFGGV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 174 CCFMISFALFMRAPRSTTNKQVednqtlkealseafanksyWLIHAGFFVCGFHVMFIatHLPSYLADKNLPASSAAMAL 253
Cdd:cd17425 167 LLNCCVCGAVMRPFCSNTRYQI-------------------YTLGVTWMVLGFVLPLI--YLVPYATSNGMDESKAALLL 225
|
250 260
....*....|....*....|....*...
gi 1327358506 254 AYVGIFNIFGSYFWGVMGDK--FSKRHV 279
Cdd:cd17425 226 SILGFINIFMRPLAGLLSGLpvFKGRRI 253
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
22-185 |
1.09e-03 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 40.89 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 22 GIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYV 101
Cdd:cd17422 17 GVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 102 SLGALVGLGLSATsyviVLGAVAKVvpAEHAAKAFGLTTAAGS----FGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCFM 177
Cdd:cd17422 97 TIGIISGLGYCFT----FLPTVTIL--SQYFKKRRSLVTAIAStgecFAVFAFAPAFTALKESIGWRYCLLVVGALQLNI 170
|
....*...
gi 1327358506 178 ISFALFMR 185
Cdd:cd17422 171 VVCGALLR 178
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
45-384 |
1.69e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.31 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 45 FSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALVGLGLsaTSYVIVLGAVA 124
Cdd:cd17341 36 IGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG--ANFASGQPWAS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 125 KVVPAEHAAKAFGLTTAAGSFG-------MFAVIPGAQYMLNEFDWQSAMQVFGVLCCFM-ISFALFMRaprsTTNKQVE 196
Cdd:cd17341 114 FWFPKEKIGGAAGGIAGAGNMGvavsqllAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAaVLVLLFGD----DLPTGKA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 197 DNQTLKEALSEAFANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIF-NIFGSYFWGVMGDKFS 275
Cdd:cd17341 190 SALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLaGALARPAGGWLSDRFG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 276 KRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTL---YGLVFFTHQVGSFL 352
Cdd:cd17341 270 GRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFRRELgavTGLVGAIGGLGGFF 349
|
330 340 350
....*....|....*....|....*....|..
gi 1327358506 353 GAWVGGRIYDYYGSYEPIWWSTVVLAFAAALI 384
Cdd:cd17341 350 LPLLFGSSALMTGSGVGAFSLFGVLAVACTLL 381
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
219-395 |
2.24e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 219 AGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVM---SALYLVRTVVIGAFV 295
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLllgLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 296 TLPVTESTAAIFGAAIGFCWlgtvPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTV 375
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVW----PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158
|
170 180
....*....|....*....|
gi 1327358506 376 VLAFAAALIHLPINDKPIER 395
Cdd:cd17325 159 LALLALVLALLLLPEPRPPP 178
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-147 |
2.29e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 46 SFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALVGLGL-SATSYVIVLGAVA 124
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLgLGLFATPLTNAAL 286
|
90 100
....*....|....*....|...
gi 1327358506 125 KVVPAEHAAKAFGLTTAAGSFGM 147
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLGG 309
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
7-111 |
2.33e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.82 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 7 PLLVWLGIGTLIISLGIRQSFGIFMMP-ISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGL 85
Cdd:cd17369 227 WRALLLAIGLRLAENVLFYLFTTFALSyATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAAL 306
|
90 100
....*....|....*....|....*...
gi 1327358506 86 GL--LLTSISTESSMLYVsLGALVGLGL 111
Cdd:cd17369 307 FAfpFFWLLDTGSTWLIV-LAAVVVLGV 333
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
8-311 |
2.80e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 8 LLVWLGIGTLIISLGIrqsfgifmmpISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGL 87
Cdd:cd17321 6 FLAALDVTIVNVALPT----------IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLAS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 88 LLTSISTESSMLyvsLGALVGLGLSATSYVIVLGA-VAKVVPAEHAAKAFGL--TTAAGSFGMFAVIPGAqyMLNEFDWQ 164
Cdd:cd17321 76 LLCALAPSLAFL---IAARALQGIGAAAIMPASLAlIAATFPGERRGRALGLwgAVVGIGAALGPLLGGL--LLELFGWR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 165 SAMQVFGVLCCFMISFAlfmraprsttnkqvednqtlkealseafanKSYWLIHAGFFVCGFHVMFIATHLPSYLAD-KN 243
Cdd:cd17321 151 WIFLINVPIGLVALLLA------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLG 200
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1327358506 244 LPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAI 311
Cdd:cd17321 201 YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLV 268
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
58-389 |
3.03e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 58 VFQPFVGMAADKWGARRII----IAGACAYGLGLLLTSISTESSMLYVSLGALVGLGLSATSYVIVLGAVakvvpAEHAA 133
Cdd:cd17335 47 LSAPLWGALADRFGKRKALlllsLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQYL-----GEERE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 134 KaFGLTTAAGS--FGMFAVIPGA--QYMLNEFDWQSAMQVFGVLccFMISFALFMRAPRSTTNKQVEDNqtlKEALSEAF 209
Cdd:cd17335 122 R-YGKQRLWGSigFGIAALLVGIliDRSSTYKNYTIAFYVFAVL--MLLALLLALKFPFRPKHPEPNEN---TGGLLALL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 210 ANKSYWLIHAGFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMS---ALYLV 286
Cdd:cd17335 196 RNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYlglLAYVV 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 287 RTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVpltsGLVRQIFGARYLSTLYGLVFFTHQ-VGSFLGAWVGGRIYDYYG 365
Cdd:cd17335 276 RWLLYSFLENPWLVLPIELLHGLTFALVWAAAV----SYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFG 351
|
330 340
....*....|....*....|....
gi 1327358506 366 SYEPiWWSTVVLAFAAALIHLPIN 389
Cdd:cd17335 352 ARTT-FRFFAIAALAGLLAFFLIQ 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
63-384 |
3.63e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 63 VGMAADKWGARRI-IIAGACAYGLGLLLTSISTESSMLYVSLGALvglGLSATSYVIVLGAVAKVVPAEHAAKAFGLTTA 141
Cdd:cd17490 51 LGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLS---GIAAATWVSFTVLYASYFPPDEAAKAMGLINL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 142 AGSFGMFAVIPGAQYMLNEFDWQSA--MQVFGVLCCFMISFalFMRAPRSTTNKQVEDNQTLKEALSeafaNKSYWLIhA 219
Cdd:cd17490 128 VNNLGQLIAFLIGGLIAEHFGMRAPflLAALAGVLGFILSL--FIKEERREKKPVLTELKELLSVLK----DKKLLFF-S 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 220 GFFVCGFHVMFIATHLPSYLADKNLPASSAAMALAYVG--IFNIFGSYFwgvMGDKFSKRHVMSALYLVRTVVIGAFVTL 297
Cdd:cd17490 201 LLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIylLPNALASLL---SGTLFYKKLGERNTIIIGFLLLGAYCFL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 298 -PVTESTAAIFGA-AIGFCWLGTV-PLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsYEPIWWST 374
Cdd:cd17490 278 iPFAPNLTLLYLLqALNGFGTGILfPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVI 356
|
330
....*....|
gi 1327358506 375 VVLAFAAALI 384
Cdd:cd17490 357 GVIALLAAIL 366
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
2-183 |
4.77e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 2 SIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGAC 81
Cdd:cd06174 198 RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 82 AYGLGLLLTSISTESSMLYVSLGALVGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEF 161
Cdd:cd06174 278 LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGL-LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
170 180
....*....|....*....|..
gi 1327358506 162 DWQSAMQVFGVLCCFMISFALF 183
Cdd:cd06174 357 FGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-149 |
6.18e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 10 VWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGL-- 87
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlg 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1327358506 88 LLTSISTESSMLYVSLGALVGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFA 149
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFGFGLV-FPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
36-182 |
6.58e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.36 E-value: 6.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 36 EHFGTGREFFSFAIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALVGLGLSATs 115
Cdd:cd17353 242 EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGG- 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1327358506 116 YVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVL--CCFMISFAL 182
Cdd:cd17353 321 FALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALslVALALALLL 389
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
62-317 |
8.31e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 37.99 E-value: 8.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 62 FVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALVGLGLSAtSYVIVLGAVAKVVPAEHAAKAFGLTTA 141
Cdd:PRK12307 72 LFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSR-FIVGMGMAG-EYACASTYAVESWPKHLKSKASAFLVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 142 AGSFGMfavIPGAQYM---LNEFDWQSAMQVfGVLCCFMIsfaLFMRAPRSTTNKQVEDNQTLKEALSEAfANKSYWLIH 218
Cdd:PRK12307 150 GFGIGN---IIAAYFMpsfAEAYGWRAAFFV-GLLPVLLV---IYIRARAPESKEWEEAKLSGKGKHSQS-AWSVFSLSM 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327358506 219 AGFF--------VCGFHVMF--------IATHLPSYLADKNLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSA 282
Cdd:PRK12307 222 KGLFnraqfpltLCVFIVLFsifganwpIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSI 301
|
250 260 270
....*....|....*....|....*....|....*
gi 1327358506 283 LYLVRTVVIGAFVTLPVTESTaaifgaAIGFCWLG 317
Cdd:PRK12307 302 GLLMSFLFIFPLFRIPQDNYL------LLGACLFG 330
|
|
| |
