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Conserved domains on  [gi|1335040921|gb|PNW75536|]
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hypothetical protein CHLRE_12g530700v5 [Chlamydomonas reinhardtii]

Protein Classification

transcription initiation factor TFIID subunit 12( domain architecture ID 10168398)

transcription initiation factor TFIID subunit 12 is a component of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC), and may be essential for mediating regulation of RNA polymerase transcription

CATH:  1.10.20.10
Gene Ontology:  GO:0005669|GO:0003677|GO:0042789|GO:0003713|GO:0006352|GO:0017025|GO:0046982|GO:0140297|GO:0006355
PubMed:  31751889|14969724|19308322
SCOP:  4000797

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HFD_TAF12 cd07981
histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and ...
 221-295 3.55e-17

histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and similar proteins; TAF12, also called TATA Binding Protein (TBP) associated factor 12, transcription initiation factor TFIID 20/15 kDa subunits, TAFII-20/TAFII-15, or TAFII20/TAFII15, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAFs are essential for mediating regulation of RNA polymerase transcription. TAF12 interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes. It is important for RAS-induced transformation properties of human colorectal cancer cells; its levels are increased in the cells harboring the RAS mutation. Also, TAF12 interacts with activating transcription factor 7 (ATF7) and contributes to the hypersensitivity of osteoclast (OCL) precursors to 1,25-dihydroxyvitamin D2 (1,25-(OH)2D3; also known as calcitriol) in Paget's disease (PD), a disorder of the bone remodeling process, in which the body absorbs old bone and forms abnormal new bone.


:

Pssm-ID: 467025 [Multi-domain]  Cd Length: 74  Bit Score: 75.64  E-value: 3.55e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1335040921 221 RLLPRRGMRMALRAAGLENhVMDPATEAALVEFYTEWVSNAVALGCEAAKRRKSgGVLKARDIALHLERSWNLAI 295
Cdd:cd07981     2 PLLSKRKLQELVREVDPNE-RLDPDVEELLLQLADDFVDDVVTFACKLAKHRGS-DTLEVKDVQLHLERNWNIRV 74
 
Name Accession Description Interval E-value
HFD_TAF12 cd07981
histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and ...
 221-295 3.55e-17

histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and similar proteins; TAF12, also called TATA Binding Protein (TBP) associated factor 12, transcription initiation factor TFIID 20/15 kDa subunits, TAFII-20/TAFII-15, or TAFII20/TAFII15, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAFs are essential for mediating regulation of RNA polymerase transcription. TAF12 interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes. It is important for RAS-induced transformation properties of human colorectal cancer cells; its levels are increased in the cells harboring the RAS mutation. Also, TAF12 interacts with activating transcription factor 7 (ATF7) and contributes to the hypersensitivity of osteoclast (OCL) precursors to 1,25-dihydroxyvitamin D2 (1,25-(OH)2D3; also known as calcitriol) in Paget's disease (PD), a disorder of the bone remodeling process, in which the body absorbs old bone and forms abnormal new bone.


Pssm-ID: 467025 [Multi-domain]  Cd Length: 74  Bit Score: 75.64  E-value: 3.55e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1335040921 221 RLLPRRGMRMALRAAGLENhVMDPATEAALVEFYTEWVSNAVALGCEAAKRRKSgGVLKARDIALHLERSWNLAI 295
Cdd:cd07981     2 PLLSKRKLQELVREVDPNE-RLDPDVEELLLQLADDFVDDVVTFACKLAKHRGS-DTLEVKDVQLHLERNWNIRV 74
COG5624 COG5624
Transcription initiation factor TFIID, subunit TAF12 [Transcription];
217-332 7.84e-13

Transcription initiation factor TFIID, subunit TAF12 [Transcription];


Pssm-ID: 227911 [Multi-domain]  Cd Length: 505  Bit Score: 69.72  E-value: 7.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335040921 217 DDDRRLLPRRGMRMALRAAGLENHVMDPATEAALVEFYTEWVSNAVALGCEAAKRRKSGgVLKARDIALHLERSWNLAIP 296
Cdd:COG5624   378 DDLWRLDSKRKLEELQHGGVDEEEKIENEVEELLLSRADGFVEPVTEFSCRLAKHRKSD-TLEVRDGQLHLERNWNIRCP 456

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1335040921 297 GFAGDVL-KPYRRANASELHRQRAAAVrRTAQELDKD 332
Cdd:COG5624   457 GFVDDIIhMSYRKQKPTVEYCQKKLAI-KTEKGIELP 492
TFIID_20kDa pfam03847
Transcription initiation factor TFIID subunit A;
239-293 3.57e-08

Transcription initiation factor TFIID subunit A;


Pssm-ID: 367691 [Multi-domain]  Cd Length: 68  Bit Score: 50.06  E-value: 3.57e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1335040921 239 NHVMDPATEAALVEFYTEWVSNAVALGCEAAKRRKSGgVLKARDIALHLERSWNL 293
Cdd:pfam03847  15 TTKLDEDVEDLLLEIADDFVESVTTFACKLAKHRKSD-KLEVRDIQLHLERNWNM 68
 
Name Accession Description Interval E-value
HFD_TAF12 cd07981
histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and ...
 221-295 3.55e-17

histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and similar proteins; TAF12, also called TATA Binding Protein (TBP) associated factor 12, transcription initiation factor TFIID 20/15 kDa subunits, TAFII-20/TAFII-15, or TAFII20/TAFII15, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAFs are essential for mediating regulation of RNA polymerase transcription. TAF12 interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes. It is important for RAS-induced transformation properties of human colorectal cancer cells; its levels are increased in the cells harboring the RAS mutation. Also, TAF12 interacts with activating transcription factor 7 (ATF7) and contributes to the hypersensitivity of osteoclast (OCL) precursors to 1,25-dihydroxyvitamin D2 (1,25-(OH)2D3; also known as calcitriol) in Paget's disease (PD), a disorder of the bone remodeling process, in which the body absorbs old bone and forms abnormal new bone.


Pssm-ID: 467025 [Multi-domain]  Cd Length: 74  Bit Score: 75.64  E-value: 3.55e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1335040921 221 RLLPRRGMRMALRAAGLENhVMDPATEAALVEFYTEWVSNAVALGCEAAKRRKSgGVLKARDIALHLERSWNLAI 295
Cdd:cd07981     2 PLLSKRKLQELVREVDPNE-RLDPDVEELLLQLADDFVDDVVTFACKLAKHRGS-DTLEVKDVQLHLERNWNIRV 74
COG5624 COG5624
Transcription initiation factor TFIID, subunit TAF12 [Transcription];
217-332 7.84e-13

Transcription initiation factor TFIID, subunit TAF12 [Transcription];


Pssm-ID: 227911 [Multi-domain]  Cd Length: 505  Bit Score: 69.72  E-value: 7.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335040921 217 DDDRRLLPRRGMRMALRAAGLENHVMDPATEAALVEFYTEWVSNAVALGCEAAKRRKSGgVLKARDIALHLERSWNLAIP 296
Cdd:COG5624   378 DDLWRLDSKRKLEELQHGGVDEEEKIENEVEELLLSRADGFVEPVTEFSCRLAKHRKSD-TLEVRDGQLHLERNWNIRCP 456

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1335040921 297 GFAGDVL-KPYRRANASELHRQRAAAVrRTAQELDKD 332
Cdd:COG5624   457 GFVDDIIhMSYRKQKPTVEYCQKKLAI-KTEKGIELP 492
TFIID_20kDa pfam03847
Transcription initiation factor TFIID subunit A;
239-293 3.57e-08

Transcription initiation factor TFIID subunit A;


Pssm-ID: 367691 [Multi-domain]  Cd Length: 68  Bit Score: 50.06  E-value: 3.57e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1335040921 239 NHVMDPATEAALVEFYTEWVSNAVALGCEAAKRRKSGgVLKARDIALHLERSWNL 293
Cdd:pfam03847  15 TTKLDEDVEDLLLEIADDFVESVTTFACKLAKHRKSD-KLEVRDIQLHLERNWNM 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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