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Conserved domains on  [gi|1338344366|gb|POM98820|]
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UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase [Salmonella enterica subsp. enterica serovar Enteritidis]

Protein Classification

Mur ligase family protein( domain architecture ID 11433699)

Mur ligase family protein similar to UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD) and UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase (MurD2), which catalyze the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

CATH:  3.40.1190.10|3.90.190.20|3.40.50.720
EC:  6.3.2.-
Gene Ontology:  GO:0008764|GO:0005524

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-437 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 554.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366   3 DYQDKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRVTPPGLD-KLPQE-VERHVGGLNDEWLLAADLIVASPGIALAHP 80
Cdd:COG0771     1 DLKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEAPgVEVVLGEHPEELLDGADLVVKSPGIPPDHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  81 SLSAAASAGVEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLD--ADRELYVLE 158
Cdd:COG0771    81 LLKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLepEPPDVYVLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 159 LSSFQLETTSSLQAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKAK---VCVVNADDALTMP-VRGADERCVSFGVN 234
Cdd:COG0771   161 LSSFQLETTPSLRPDVAVILNITPDHLDRHG-SMEAYAAAKARIFANQTpddYAVLNADDPLTRAlAEEAKARVVPFSLK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 235 M---GDYHLnrQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHN 311
Cdd:COG0771   240 EpleGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEIN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 312 GVRWINDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLTRYLTGDRIRLYCFGRDGAQLAALRPEIA---QQT 388
Cdd:COG0771   318 GVRFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAGvpvVIV 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1338344366 389 ETMEEAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGDVFTRLAKEL 437
Cdd:COG0771   396 ETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVREL 444
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-437 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 554.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366   3 DYQDKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRVTPPGLD-KLPQE-VERHVGGLNDEWLLAADLIVASPGIALAHP 80
Cdd:COG0771     1 DLKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEAPgVEVVLGEHPEELLDGADLVVKSPGIPPDHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  81 SLSAAASAGVEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLD--ADRELYVLE 158
Cdd:COG0771    81 LLKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLepEPPDVYVLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 159 LSSFQLETTSSLQAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKAK---VCVVNADDALTMP-VRGADERCVSFGVN 234
Cdd:COG0771   161 LSSFQLETTPSLRPDVAVILNITPDHLDRHG-SMEAYAAAKARIFANQTpddYAVLNADDPLTRAlAEEAKARVVPFSLK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 235 M---GDYHLnrQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHN 311
Cdd:COG0771   240 EpleGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEIN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 312 GVRWINDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLTRYLTGDRIRLYCFGRDGAQLAALRPEIA---QQT 388
Cdd:COG0771   318 GVRFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAGvpvVIV 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1338344366 389 ETMEEAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGDVFTRLAKEL 437
Cdd:COG0771   396 ETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVREL 444
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 8-435 1.85e-151

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 436.77  E-value: 1.85e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366   8 NVVIIGLGLTGLSCVDFFLARGVTPRVMDTRVTP-----PGLDKLPQEVERHVGgLNDEWLLAADLIVASPGIALAHPSL 82
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEelepsMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  83 SAAASAGVEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDADR-ELYVLELSS 161
Cdd:TIGR01087  80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDQEGaELYVLELSS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 162 FQLETTSSLQAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYE---KAKVCVVNADD---ALTMPVRGAdeRCVSFGV-N 234
Cdd:TIGR01087 160 FQLETTESLRPEIALILNISEDHLDWHG-SFEDYVAAKLKIFArqtEGDVAVLNADDprfARLAQKSKA--QVIWFSVeK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 235 MGDYHLNRQQGETWLRVKGEkvlnvkEMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHNGVR 314
Cdd:TIGR01087 237 DAERGLCIRDGGLYLKPNDL------EGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVH 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 315 WINDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLTRYLTGDRIRLYCFGRDGAQLAALRPEIAQQT---ETM 391
Cdd:TIGR01087 311 FYNDSKATNVHATLAALSAF--DNPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVylvESL 388

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1338344366 392 EEAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGDVFTRLAK 435
Cdd:TIGR01087 389 EEAVQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 3-437 1.80e-95

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 294.19  E-value: 1.80e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366   3 DYQDKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRVTPP---GLDKLPQE-VERHVGGLNDEWLLAADLIVASPGIALA 78
Cdd:PRK14106    2 ELKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQlkeALEELGELgIELVLGEYPEEFLEGVDLVVVSPGVPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  79 HPSLSAAASAGVEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPAL-MLLDADRE-LYV 156
Cdd:PRK14106   82 SPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPLIdAVEEYGEDdIIV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 157 LELSSFQLETTSSLQAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKAK---VCVVNADDALTMPV-RGADERCVSF- 231
Cdd:PRK14106  162 AEVSSFQLETIKEFKPKVGCILNITPDHLDRHK-TMENYIKAKARIFENQRpsdYTVLNYDDPRTRSLaKKAKARVIFFs 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 232 -------GVNMgdyhlnrQQGETWLRVKG--EKVLNVKEMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAH 302
Cdd:PRK14106  241 rkslleeGVFV-------KNGKIVISLGGkeEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEH 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 303 RFQLALEHNGVRWINDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLTRYLTGDRIRLYCFGRDGAQLAalrp 382
Cdd:PRK14106  314 RIEFVAEINGVKFINDSKGTNPDAAIKALEAY--ETPIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIA---- 387

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1338344366 383 EIAQQT--------ETMEEAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGDVFTRLAKEL 437
Cdd:PRK14106  388 EAARKYgfdnilfaETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
Mur_ligase_M pfam08245
Mur ligase middle domain;
110-272 8.26e-21

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 89.67  E-value: 8.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 110 ITGSNGKSTVTTLVGEMAKAAGVNVGVGGN------------IGLPALM--LLDADRELYVLELSSFQLE---TTSSLQA 172
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTLaeMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 173 AAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKAKVC---VVNADDALTMPVR----GADERCVSFGVN------MGDYH 239
Cdd:pfam08245  81 DIAVFTNISPDHLDFHG-TMENYAKAKAELFEGLPEDgiaVINADDPYGAFLIaklkKAGVRVITYGIEgeadlrAANIE 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1338344366 240 LNRQQGETWLRVKGEKVLNVkEMKLSGQHNYTN 272
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELEI-EIPLLGRHNVYN 191
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-437 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 554.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366   3 DYQDKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRVTPPGLD-KLPQE-VERHVGGLNDEWLLAADLIVASPGIALAHP 80
Cdd:COG0771     1 DLKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEAPgVEVVLGEHPEELLDGADLVVKSPGIPPDHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  81 SLSAAASAGVEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLD--ADRELYVLE 158
Cdd:COG0771    81 LLKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLepEPPDVYVLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 159 LSSFQLETTSSLQAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKAK---VCVVNADDALTMP-VRGADERCVSFGVN 234
Cdd:COG0771   161 LSSFQLETTPSLRPDVAVILNITPDHLDRHG-SMEAYAAAKARIFANQTpddYAVLNADDPLTRAlAEEAKARVVPFSLK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 235 M---GDYHLnrQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHN 311
Cdd:COG0771   240 EpleGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEIN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 312 GVRWINDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLTRYLTGDRIRLYCFGRDGAQLAALRPEIA---QQT 388
Cdd:COG0771   318 GVRFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAGvpvVIV 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1338344366 389 ETMEEAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGDVFTRLAKEL 437
Cdd:COG0771   396 ETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVREL 444
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 8-435 1.85e-151

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 436.77  E-value: 1.85e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366   8 NVVIIGLGLTGLSCVDFFLARGVTPRVMDTRVTP-----PGLDKLPQEVERHVGgLNDEWLLAADLIVASPGIALAHPSL 82
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEelepsMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  83 SAAASAGVEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDADR-ELYVLELSS 161
Cdd:TIGR01087  80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDQEGaELYVLELSS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 162 FQLETTSSLQAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYE---KAKVCVVNADD---ALTMPVRGAdeRCVSFGV-N 234
Cdd:TIGR01087 160 FQLETTESLRPEIALILNISEDHLDWHG-SFEDYVAAKLKIFArqtEGDVAVLNADDprfARLAQKSKA--QVIWFSVeK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 235 MGDYHLNRQQGETWLRVKGEkvlnvkEMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHNGVR 314
Cdd:TIGR01087 237 DAERGLCIRDGGLYLKPNDL------EGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVH 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 315 WINDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLTRYLTGDRIRLYCFGRDGAQLAALRPEIAQQT---ETM 391
Cdd:TIGR01087 311 FYNDSKATNVHATLAALSAF--DNPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVylvESL 388

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1338344366 392 EEAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGDVFTRLAK 435
Cdd:TIGR01087 389 EEAVQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 3-437 1.80e-95

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 294.19  E-value: 1.80e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366   3 DYQDKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRVTPP---GLDKLPQE-VERHVGGLNDEWLLAADLIVASPGIALA 78
Cdd:PRK14106    2 ELKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQlkeALEELGELgIELVLGEYPEEFLEGVDLVVVSPGVPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  79 HPSLSAAASAGVEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPAL-MLLDADRE-LYV 156
Cdd:PRK14106   82 SPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPLIdAVEEYGEDdIIV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 157 LELSSFQLETTSSLQAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKAK---VCVVNADDALTMPV-RGADERCVSF- 231
Cdd:PRK14106  162 AEVSSFQLETIKEFKPKVGCILNITPDHLDRHK-TMENYIKAKARIFENQRpsdYTVLNYDDPRTRSLaKKAKARVIFFs 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 232 -------GVNMgdyhlnrQQGETWLRVKG--EKVLNVKEMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAH 302
Cdd:PRK14106  241 rkslleeGVFV-------KNGKIVISLGGkeEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEH 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 303 RFQLALEHNGVRWINDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLTRYLTGDRIRLYCFGRDGAQLAalrp 382
Cdd:PRK14106  314 RIEFVAEINGVKFINDSKGTNPDAAIKALEAY--ETPIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIA---- 387

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1338344366 383 EIAQQT--------ETMEEAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGDVFTRLAKEL 437
Cdd:PRK14106  388 EAARKYgfdnilfaETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
Mur_ligase_M pfam08245
Mur ligase middle domain;
110-272 8.26e-21

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 89.67  E-value: 8.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 110 ITGSNGKSTVTTLVGEMAKAAGVNVGVGGN------------IGLPALM--LLDADRELYVLELSSFQLE---TTSSLQA 172
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTLaeMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 173 AAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKAKVC---VVNADDALTMPVR----GADERCVSFGVN------MGDYH 239
Cdd:pfam08245  81 DIAVFTNISPDHLDFHG-TMENYAKAKAELFEGLPEDgiaVINADDPYGAFLIaklkKAGVRVITYGIEgeadlrAANIE 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1338344366 240 LNRQQGETWLRVKGEKVLNVkEMKLSGQHNYTN 272
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELEI-EIPLLGRHNVYN 191
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 101-410 1.32e-19

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 90.55  E-value: 1.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 101 REAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGN----IGLPaLMLL--DADRELYVLEL--SSF-QLETTSSL- 170
Cdd:COG0770    96 ARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNfnneIGVP-LTLLrlPEDHEFAVLEMgmNHPgEIAYLARIa 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 171 QAAAATVLNVTEDHMDRypFG-LQQYRAAKLRVYE---KAKVCVVNADDALTMP-VRGADERCVSFGVNMG------DYH 239
Cdd:COG0770   175 RPDIAVITNIGPAHLEG--FGsLEGIARAKGEIFEglpPGGVAVLNADDPLLAAlAERAKARVLTFGLSEDadvraeDIE 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 240 LNRQQGETWLRVKGEKVlNVKeMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHNGVRWINDS 319
Cdd:COG0770   253 LDEDGTRFTLHTPGGEL-EVT-LPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDS 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 320 -KAtNVGSTEAA---LNGLHVDGTLHLLLGGDGKSADFSP-----LTRYLTGDRI-RLYCFGRDGAQLA-ALRPEIAQQT 388
Cdd:COG0770   331 yNA-NPDSMKAAldvLAQLPGGGRRIAVLGDMLELGEESEelhreVGELAAELGIdRLFTVGELARAIAeAAGGERAEHF 409

                         330       340
                  ....*....|....*....|..
gi 1338344366 389 ETMEEAMRLLAPRVQPGDMVLL 410
Cdd:COG0770   410 EDKEELLAALKALLRPGDVVLV 431
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 68-410 1.70e-19

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 90.02  E-value: 1.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  68 LIVASPGIALAhpslsAAASAgveivgdielFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGN----IGLP 143
Cdd:TIGR01143  52 ILVDDTLEALQ-----ALARA----------KRAKFSGKVIGITGSSGKTTTKEMLAAILSHKYKVFATPGNfnneIGLP 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 144 -ALMLLDADRELYVLELS-SFQLE---TTSSLQAAAATVLNVTEDHMDRypFGLQQYRA-AKLRVYEKAKVC---VVNAD 214
Cdd:TIGR01143 117 lTLLRAPGDHDYAVLEMGaSHPGEiayLAEIAKPDIAVITNIGPAHLEG--FGSLEGIAeAKGEILQGLKENgiaVINAD 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 215 DALTMPVRG--ADERCVSFGVNMGDYHLN----RQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAVGLPRA 288
Cdd:TIGR01143 195 DPAFADLAKrlPNRNILSFGFEGGDFVAKdisySALGSTSFTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLE 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 289 SSLKALTTFTGLAHRFQlALEHNGVRWINDSKATNVGSTEAALNGL-HVDGTLHLLLGGDGKSADFSPLTRYLTGDRI-- 365
Cdd:TIGR01143 275 EIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALDALaRFPGKKILVLGDMAELGEYSEELHAEVGRYAns 353

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1338344366 366 ----RLYCFGRDGAQLAALRPEIAQQTETMEEAMRLLAPRVQPGDMVLL 410
Cdd:TIGR01143 354 lgidLVFLVGEEAAVIYDSFGKQGKHFADKDELLAFLKTLVRKGDVVLV 402
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 61-318 3.69e-16

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 80.11  E-value: 3.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  61 EWLLAADLIVASPGIALAHPSLSAAASAGVEIV------GDIelfCREAQApiVAITGSNGKSTVTTLVGEMAKAAGVNV 134
Cdd:COG0773    59 ENIDDADLVVVSSAIPRDNPELVAARERGIPVLsraemlAEL---MRGKRS--IAVAGTHGKTTTTSMLAHILEEAGLDP 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 135 G--VGG---NIGLPALMlldADRELYVLE----LSSFQLettssLQAAAATVLNVTEDHMDRYPfGLQQYRAA------K 199
Cdd:COG0773   134 TflIGGilnNFGTNARL---GDGDYFVAEadesDGSFLH-----YSPDIAVVTNIEADHLDIYG-DLEAIKEAfhefarN 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 200 LRVYEKAkvcVVNADDALTMPV-RGADERCVSFGVNM-GDYHL-NRQQGETW----LRVKGEKVLNVkEMKLSGQHNYTN 272
Cdd:COG0773   205 VPFYGLL---VLCADDPGLRELlPRCGRPVITYGFSEdADYRAeNIRIDGGGstfdVLRRGEELGEV-ELNLPGRHNVLN 280

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1338344366 273 ALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHNGVRWIND 318
Cdd:COG0773   281 ALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTVIDD 326
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 107-348 1.01e-13

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 72.80  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 107 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIG-------------------LPALM--LLDADRELYVLELSSFQLE 165
Cdd:COG0769    82 LIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGngiggelipsslttpealdLQRLLaeMVDAGVTHVVMEVSSHALD 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 166 T--TSSLQAAAATVLNVTEDHMDrYPFGLQQYRAAKLRV---YEKAKVCVVNADDALTMP-VRGADERCVSFGV-NMGDY 238
Cdd:COG0769   162 QgrVDGVRFDVAVFTNLTRDHLD-YHGTMEAYFAAKARLfdqLGPGGAAVINADDPYGRRlAAAAPARVITYGLkADADL 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 239 H---LNRQQGETWLRVK---GEKVLNVKemkLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHNG 312
Cdd:COG0769   241 RatdIELSADGTRFTLVtpgGEVEVRLP---LIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDGGQG 317

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1338344366 313 VRWINDSkATNVGSTEAALNGL--HVDGTLHLLLGGDG 348
Cdd:COG0769   318 PTVIVDY-AHTPDALENVLEALrpHTKGRLIVVFGCGG 354
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 101-409 6.13e-12

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 67.81  E-value: 6.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 101 REAQA-PIVAITGSNGKSTVTTLVGEMAKAAGVNVGV---GGN----IGLP-ALMLLDADRELYVLEL---SSFQLETTS 168
Cdd:PRK11929  598 RARFSlPVVAITGSNGKTTTKEMIAAILAAWQGEDRVlatEGNfnneIGVPlTLLRLRAQHRAAVFELgmnHPGEIAYLA 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 169 SL-QAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKAK---VCVVNADDALT-MPVRGADERCV-SFGVNMG------ 236
Cdd:PRK11929  678 AIaAPTVALVTNAQREHQEFMH-SVEAVARAKGEIIAALPedgVAVVNGDDPYTaIWAKLAGARRVlRFGLQPGadvyae 756

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 237 ----DYHLNRQQGETWLRVKGEKVLNVkEMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHNG 312
Cdd:PRK11929  757 kiakDISVGEAGGTRCQVVTPAGSAEV-YLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCG 835

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 313 VRWINDSKATNVGSTEAALNGL-HVDGTLHLLLGGD-GKSADFSPLTRYLTGDRIR------LYCFGRDGAQLAALRPEI 384
Cdd:PRK11929  836 TRIIDDTYNANPDSMRAAIDVLaELPNGPRALVLGDmLELGDNGPAMHREVGKYARqlgidaLITLGEAARDAAAAFGAG 915

                         330       340
                  ....*....|....*....|....*.
gi 1338344366 385 AQ-QTETMEEAMRLLAPRVQPGDMVL 409
Cdd:PRK11929  916 ARgVCASVDEIIAALRGALPEGDSVL 941
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 107-305 2.34e-09

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 59.72  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 107 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIG-------------------LPALM--LLDADRELYVLELSSFQLE 165
Cdd:PRK11929  114 LVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGarldgrlipgslttpdaiiLHRILarMRAAGADAVAMEASSHGLE 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 166 TT--SSLQAAAATVLNVTEDHMDrYPFGLQQYRAAKLRVYEKAK---VCVVNADDALTMPVRGADERCVSFGVNMG---- 236
Cdd:PRK11929  194 QGrlDGLRIAVAGFTNLTRDHLD-YHGTMQDYEEAKAALFSKLPglgAAVINADDPAAARLLAALPRGLKVGYSPQnaga 272

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1338344366 237 --DYHLNRQ--QGETWLRVKGEKVLNVKeMKLSGQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQ 305
Cdd:PRK11929  273 dvQARDLRAtaHGQVFTLATPDGSYQLV-TRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRME 344
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 107-312 3.48e-09

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 58.60  E-value: 3.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 107 IVAITGSNGKSTVTTLVGEMAKAAG--------VNVGVGGN-----------IGLPALM--LLDADRELYVLELSSFQLE 165
Cdd:PRK00139   97 LIGVTGTNGKTTTAYLLAQILRLLGektaligtLGNGIGGElipsglttpdaLDLQRLLaeLVDAGVTYAAMEVSSHALD 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 166 T--TSSLQAAAATVLNVTEDHMDRYPfGLQQYRAAKLRVYEKA-KVCVVNADDALTMPVRgADERCVSFGVNMGDYHLNR 242
Cdd:PRK00139  177 QgrVDGLKFDVAVFTNLSRDHLDYHG-TMEDYLAAKARLFSELgLAAVINADDEVGRRLL-ALPDAYAVSMAGADLRATD 254

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1338344366 243 QQgetwLRVKGEKVLNVKEMKLS--GQHNYTNALAALALADAVGLPRASSLKALTTFTGLAHRFQLALEHNG 312
Cdd:PRK00139  255 VE----YTDSGQTFTLVTEVESPliGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVDAGQG 322
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 107-218 8.21e-09

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 57.33  E-value: 8.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366 107 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGL----------------P-ALMLLDADRELYVLELSSFQLETTS- 168
Cdd:TIGR01085  87 VIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYrlggndliknpaalttPeALTLQSTLAEMVEAGAQYAVMEVSSh 166

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1338344366 169 --------SLQAAAATVLNVTEDHMDrYPFGLQQYRAAKLRVYEK---AKVCVVNADDALT 218
Cdd:TIGR01085 167 alaqgrvrGVRFDAAVFTNLSRDHLD-FHGTMENYFAAKASLFTElglKRFAVINLDDEYG 226
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 302-356 3.70e-07

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 47.72  E-value: 3.70e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1338344366 302 HRFQLALEHNGVRWINDsKATNVGSTEAALNGL--HVDGTLHLLLGGDG-KSADFSPL 356
Cdd:pfam02875   3 GRLEVVGENNGVLVIDD-YAHNPDAMEAALRALrnLFPGRLILVFGGMGdRDAEFHAL 59
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 71-136 7.56e-06

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 48.23  E-value: 7.56e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1338344366  71 ASPGIaLAH--PSLSAAASAGVEIVGdiELFCREAQA--PIVAITGSNGKSTVTTLVGEMAKAAGVNVGV 136
Cdd:PRK14016  445 AAPGL-RMHlaPSEGKPRNVGEAIVD--MLFPEGDDGriPIVAVTGTNGKTTTTRLIAHILKLSGKRVGM 511
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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