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Conserved domains on  [gi|1340243864|gb|POV83885|]
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Crp/Fnr family transcriptional regulator [Enterobacter cloacae complex sp. ECNIH9]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HTH_46 super family cl37901
Winged helix-turn-helix DNA binding;
140-207 1.43e-24

Winged helix-turn-helix DNA binding;


The actual alignment was detected with superfamily member pfam15977:

Pssm-ID: 435049 [Multi-domain]  Cd Length: 68  Bit Score: 91.57  E-value: 1.43e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1340243864 140 AYEMIRQQLIKLMEEDESYRGSVTAERYIREKTQLSRSGVMRILADLKTGGFIEMEEGRLLKINKLPA 207
Cdd:pfam15977   1 SYDIIRALLLELMDLPEEFRENISVLNYIQQRTHLSRSSIMKILSELKKGGYIEIDRGRLVAINNLPS 68
PRK11832 super family cl32729
hydrogen peroxide resistance inhibitor IprA;
43-209 1.83e-20

hydrogen peroxide resistance inhibitor IprA;


The actual alignment was detected with superfamily member PRK11832:

Pssm-ID: 183332 [Multi-domain]  Cd Length: 207  Bit Score: 84.93  E-value: 1.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864  43 QGMCYLILEGTVAIyRRSDDMMLSTARSPALFGLAN-LTDIYFNDYLKTVSPCLIGTLTAERVNDIIKEKSLWgllskQL 121
Cdd:PRK11832   41 NEDTFVILEGVISL-RREENVLIGITQAPYIMGLADgLMKNDIPYKLISEGNCTGYHLPAKQTITLIEQNQLW-----RD 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864 122 MFVYSRLYNNVMPQG-----APTAYEMIRQQLIKLMEEDESYRGSVTAERYIREKTQLSRSGVMRILADLKTGGFIEMEE 196
Cdd:PRK11832  115 AFYWLAWQNRILELRdvqliGHNSYEQIRATLLSMIDWNEELRSRIGVMNYIHQRTRISRSVVAEVLAALRKGGYIEMNK 194
                         170
                  ....*....|...
gi 1340243864 197 GRLLKINKLPARY 209
Cdd:PRK11832  195 GKLVAINRLPSEY 207
 
Name Accession Description Interval E-value
HTH_46 pfam15977
Winged helix-turn-helix DNA binding;
140-207 1.43e-24

Winged helix-turn-helix DNA binding;


Pssm-ID: 435049 [Multi-domain]  Cd Length: 68  Bit Score: 91.57  E-value: 1.43e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1340243864 140 AYEMIRQQLIKLMEEDESYRGSVTAERYIREKTQLSRSGVMRILADLKTGGFIEMEEGRLLKINKLPA 207
Cdd:pfam15977   1 SYDIIRALLLELMDLPEEFRENISVLNYIQQRTHLSRSSIMKILSELKKGGYIEIDRGRLVAINNLPS 68
PRK11832 PRK11832
hydrogen peroxide resistance inhibitor IprA;
43-209 1.83e-20

hydrogen peroxide resistance inhibitor IprA;


Pssm-ID: 183332 [Multi-domain]  Cd Length: 207  Bit Score: 84.93  E-value: 1.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864  43 QGMCYLILEGTVAIyRRSDDMMLSTARSPALFGLAN-LTDIYFNDYLKTVSPCLIGTLTAERVNDIIKEKSLWgllskQL 121
Cdd:PRK11832   41 NEDTFVILEGVISL-RREENVLIGITQAPYIMGLADgLMKNDIPYKLISEGNCTGYHLPAKQTITLIEQNQLW-----RD 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864 122 MFVYSRLYNNVMPQG-----APTAYEMIRQQLIKLMEEDESYRGSVTAERYIREKTQLSRSGVMRILADLKTGGFIEMEE 196
Cdd:PRK11832  115 AFYWLAWQNRILELRdvqliGHNSYEQIRATLLSMIDWNEELRSRIGVMNYIHQRTRISRSVVAEVLAALRKGGYIEMNK 194
                         170
                  ....*....|...
gi 1340243864 197 GRLLKINKLPARY 209
Cdd:PRK11832  195 GKLVAINRLPSEY 207
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
15-199 7.80e-08

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 50.76  E-value: 7.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864  15 QELISHLLPDCTTRQTARGERLDLQIDGQGMCYLILEGTVAIYRRSDD---MMLSTARSPALFGLAN-LTDIYFNDYLKT 90
Cdd:COG0664     6 DEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDgreQILGFLGPGDFFGELSlLGGEPSPATAEA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864  91 VSPCLIGTLTAERVNDIIKE-----KSLWGLLSKQLMFVYSRLYNNvmpqGAPTAYEMIRQQLIKLMEEDESYRGSVTAE 165
Cdd:COG0664    86 LEDSELLRIPREDLEELLERnpelaRALLRLLARRLRQLQERLVSL----AFLSAEERLARFLLELADRLDGRIDLPLTQ 161
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1340243864 166 RYIREKTQLSRSGVMRILADLKTGGFIEMEEGRL 199
Cdd:COG0664   162 EEIASYLGLTRETVSRILKKLEKEGLIELERGRI 195
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
46-110 5.70e-03

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 34.89  E-value: 5.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1340243864  46 CYLILEGTVAIYRRSDD---MMLSTARSPALFG-LANLTDIYFNDYLKTVSPCLIGTLTAERVNDIIKE 110
Cdd:pfam00027  20 LYIVLSGKVKVYRTLEDgreQILAVLGPGDFFGeLALLGGEPRSATVVALTDSELLVIPREDFLELLER 88
 
Name Accession Description Interval E-value
HTH_46 pfam15977
Winged helix-turn-helix DNA binding;
140-207 1.43e-24

Winged helix-turn-helix DNA binding;


Pssm-ID: 435049 [Multi-domain]  Cd Length: 68  Bit Score: 91.57  E-value: 1.43e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1340243864 140 AYEMIRQQLIKLMEEDESYRGSVTAERYIREKTQLSRSGVMRILADLKTGGFIEMEEGRLLKINKLPA 207
Cdd:pfam15977   1 SYDIIRALLLELMDLPEEFRENISVLNYIQQRTHLSRSSIMKILSELKKGGYIEIDRGRLVAINNLPS 68
PRK11832 PRK11832
hydrogen peroxide resistance inhibitor IprA;
43-209 1.83e-20

hydrogen peroxide resistance inhibitor IprA;


Pssm-ID: 183332 [Multi-domain]  Cd Length: 207  Bit Score: 84.93  E-value: 1.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864  43 QGMCYLILEGTVAIyRRSDDMMLSTARSPALFGLAN-LTDIYFNDYLKTVSPCLIGTLTAERVNDIIKEKSLWgllskQL 121
Cdd:PRK11832   41 NEDTFVILEGVISL-RREENVLIGITQAPYIMGLADgLMKNDIPYKLISEGNCTGYHLPAKQTITLIEQNQLW-----RD 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864 122 MFVYSRLYNNVMPQG-----APTAYEMIRQQLIKLMEEDESYRGSVTAERYIREKTQLSRSGVMRILADLKTGGFIEMEE 196
Cdd:PRK11832  115 AFYWLAWQNRILELRdvqliGHNSYEQIRATLLSMIDWNEELRSRIGVMNYIHQRTRISRSVVAEVLAALRKGGYIEMNK 194
                         170
                  ....*....|...
gi 1340243864 197 GRLLKINKLPARY 209
Cdd:PRK11832  195 GKLVAINRLPSEY 207
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
15-199 7.80e-08

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 50.76  E-value: 7.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864  15 QELISHLLPDCTTRQTARGERLDLQIDGQGMCYLILEGTVAIYRRSDD---MMLSTARSPALFGLAN-LTDIYFNDYLKT 90
Cdd:COG0664     6 DEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDgreQILGFLGPGDFFGELSlLGGEPSPATAEA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340243864  91 VSPCLIGTLTAERVNDIIKE-----KSLWGLLSKQLMFVYSRLYNNvmpqGAPTAYEMIRQQLIKLMEEDESYRGSVTAE 165
Cdd:COG0664    86 LEDSELLRIPREDLEELLERnpelaRALLRLLARRLRQLQERLVSL----AFLSAEERLARFLLELADRLDGRIDLPLTQ 161
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1340243864 166 RYIREKTQLSRSGVMRILADLKTGGFIEMEEGRL 199
Cdd:COG0664   162 EEIASYLGLTRETVSRILKKLEKEGLIELERGRI 195
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
46-110 5.70e-03

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 34.89  E-value: 5.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1340243864  46 CYLILEGTVAIYRRSDD---MMLSTARSPALFG-LANLTDIYFNDYLKTVSPCLIGTLTAERVNDIIKE 110
Cdd:pfam00027  20 LYIVLSGKVKVYRTLEDgreQILAVLGPGDFFGeLALLGGEPRSATVVALTDSELLVIPREDFLELLER 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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