|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
17-412 |
1.77e-129 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 379.37 E-value: 1.77e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 17 LGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAG 96
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 97 SWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFI 176
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 177 WAMCWLVFYKHPRDQKKLSDEERDYILNGQ----ESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPL 252
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGllaeQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 253 FMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWfGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYIAIALL 332
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRR-GKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 333 CVGGFAHQAlSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIG-FSPLFAVLAVFDLLGALVIWTV 411
Cdd:TIGR00893 320 ALGFFGLGA-GAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVVAALALIGALSYLLL 398
|
.
gi 1347933230 412 L 412
Cdd:TIGR00893 399 V 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-411 |
4.05e-92 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 282.15 E-value: 4.05e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 168 IISGALSFIWAMCWLVFYkhprdqkklsdeerdyilngqesqhknstakkmslgqilrnRQFWGIALPRFLAEPAWGTFN 247
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINYALYGLL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWfgvnliVSRKMVVTMGALLMIGPGMIGLFTSPYI 327
Cdd:cd17319 200 TWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 328 AIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFDLLGAL 406
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVALLAAL 353
|
....*
gi 1347933230 407 VIWTV 411
Cdd:cd17319 354 LVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-412 |
4.11e-66 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 215.50 E-value: 4.11e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 1 MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAM 80
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 81 FAVLWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 161 HSWQMAFIISGALSFIWAMCwlvfykhprdqkklsdeerdyilngqesqhknstakkmslgqilrnrQFWGIALPRFLAE 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 241 PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnliVSRKMVVTMGALLMIGPGMIG 320
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-------RRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 321 LFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVF 400
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
410
....*....|..
gi 1347933230 401 DLLGALVIWTVL 412
Cdd:COG2271 347 ALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-421 |
1.07e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 162.74 E-value: 1.07e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 168 IISGALSFIWAMCWLVFYKHPrdqkklsdeerdyilngQESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFN 247
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDP-----------------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKMVVTMGALLMIGPGMIGLFT-SPY 326
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG---------RRVLLIVFALMALGLLLLALALgSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 327 IAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIG-FSPLFAVLAVFDLLGA 405
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVAL 376
|
410
....*....|....*.
gi 1347933230 406 LVIWTVLQNKSASEVE 421
Cdd:COG2223 377 VLTLLLYRRPRRAAAA 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-376 |
1.56e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 131.63 E-value: 1.56e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 1 MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAM 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 81 FAVLWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 161 HSWQMAFIISGALSFIWAMCWLVFYKhprdqkklsdeerdyilngqESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAE 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLP--------------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 241 PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKMVVTMGALLMIGPGMIG 320
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR---------RRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1347933230 321 LFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTL 376
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-409 |
4.24e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 125.38 E-value: 4.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAEA 113
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIwAMCWLVFYKHPRDqkk 193
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-ALVLALLLLPEPR--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 194 lsdeerdyilNGQESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPM 273
Cdd:cd17325 176 ----------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 274 LFADLGCIVGGYLPplfqRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSD 352
Cdd:cd17325 246 LASALSQPPAGKLS----DRIG------RKPLILIGLLLSaVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1347933230 353 VFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-378 |
1.35e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 123.30 E-value: 1.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 15 VTLGTVLGYLTRNTVAAAAP-TLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 94 LAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGAL 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 174 SFIWAMCWLVFYKHPRDQKKLSDEERDYILngqesqhknstakkMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSL--------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 254 MfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLmigpgmIGLFTSPYIAIALLC 333
Cdd:pfam07690 227 Q-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL------LSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1347933230 334 VGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFA 378
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
16-394 |
1.50e-31 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 124.03 E-value: 1.50e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 16 TLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALA 95
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 96 GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH-SWQMAFIISGALS 174
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 175 FIWAMCWLVFYKHPRDQKKLS--DEER-DYILNGQESQHKNSTAKKMSLGQILRNRQFWGIALPR-FLAEPAWGtFNAWI 250
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPpaEEMPnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYvFVYVVRTG-ILDWS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 251 PLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLF--QRWFGVNLIVSRKMVVTMGALLMIgpgmigLFTSPYIA 328
Cdd:TIGR00881 240 PLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLN------PAANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1347933230 329 IALLCVGGF---AHQALSGaliTLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLF 394
Cdd:TIGR00881 314 LICLFALGFlvyGPQMLIG---VIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-409 |
9.17e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 115.99 E-value: 9.17e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAI--VMHSWQMAFIISGA 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 173 LSFIWAMCWLVFYKHPRDQKKLSDEERDYILNGQesqhknstakkmSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPL 252
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLK------------LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 253 FMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGylpplfqrWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYIAIALL 332
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG--------LLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1347933230 333 CVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-418 |
8.03e-25 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 105.32 E-value: 8.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 5 KGLRWYMIALVTLGTVLGYLTrNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVL 84
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFAT-ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 85 WAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIaVGYFNVGSSIGAMIAPPLVVWAIVMH--- 161
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGlsl 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 162 SWQMAFIISGALSFIWAMcWLVFYKHPRDqkklsdeerdyilngqESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEP 241
Cdd:COG0738 162 SWHLPYLILAVLLLLLAL-LFLRSKLPEI----------------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 242 AWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGPGMIGL 321
Cdd:COG0738 225 AEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL---------LKRFGPVRLLRLSALLAAVGLLLALL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 322 FTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAwLASTLFALVVGALADTIGFSPLFAVLAVFD 401
Cdd:COG0738 296 APGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCY 374
|
410
....*....|....*..
gi 1347933230 402 LLGALVIWTVLQNKSAS 418
Cdd:COG0738 375 LLILLLALALKRKRRKK 391
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
11-409 |
1.67e-23 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 101.54 E-value: 1.67e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 11 MIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK--IGYAMFAvlWAVF 88
Cdd:cd17318 22 IVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKrvLGYSILI--TALL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 89 CGATALA--GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMA 166
Cdd:cd17318 100 TLLTPLAarGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 167 FIISGALSFIWAMCWLVFYkhprdqkklsdeerdyilngqesqhknstakkmslgqilrnRQFWGIALPRFLAEPAWGTF 246
Cdd:cd17318 180 FYIFGGLGLLWCLLWFFLV-----------------------------------------LPVWAIVVAHFGHNWGFYTL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 247 NAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMG----ALLMIGPGMIGlf 322
Cdd:cd17318 219 LTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTSIGflgpGVFLIALGYLG-- 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 323 TSPYIAIALLCV----GGFAHQALSGALITLSSDVFGrnevaTANGLTGMSAWLASTLFALVVGAL---ADTIG-FSPLF 394
Cdd:cd17318 297 SNATLAVVFLTLsvglSGACYSGFLVNHLDLAPNYAG-----TLMGITNTAATIAGIISPLIVGAIvknDQTIGqWRIVF 371
|
410
....*....|....*
gi 1347933230 395 AVLAVFDLLGALVIW 409
Cdd:cd17318 372 FISAAIYILGAIFYL 386
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
13-385 |
6.43e-23 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 100.00 E-value: 6.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 13 ALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGAT 92
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 93 ALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAppLVVWAIVMH---SWQMAFII 169
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG--YVVGGLVAQatgGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 170 SGALSFIwaMCWLVFYKHPRDQKKLSDEERDyilngqesQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAW 249
Cdd:cd17328 160 TGVLGVL--LAILLLLFVREPPRGAAEGGVM--------AKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 250 IPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMI---GPGMIGLFTSPY 326
Cdd:cd17328 230 APTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAApflFLALVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 327 IAIALLCVGGFAH-----------------------------------QALSGALITLSSDVFGRNEVATANGLTGMSAW 371
Cdd:cd17328 310 LAWVLLFLGEFLLslnwapvfaillyvviptrrstasaiqillshllgDAGSPYLIGLISDLLRQNKDSPLAEAASLQYA 389
|
410
....*....|....
gi 1347933230 372 LASTLFALVVGALA 385
Cdd:cd17328 390 LLLCSFVLVLGGFF 403
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
8-406 |
1.12e-22 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 99.24 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK----IGYAMFAV 83
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKrflaIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 84 LWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM--- 160
Cdd:cd17345 81 INILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIfgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 161 HSWQMAFIISGALSFIWAMCWLVFYKH-------PRDQKKLSDEERDYILNGQEsqhKNSTAKKMSLGQILRNRQFWGIA 233
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDtpeseglPPIEEYKGDYPEEADGEEEE---QELSAWEIFVKYVLKNKLLWYIA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 234 LPR-FLAEPAWGTFNaWIPLFMFKVYGFNLKE----IAMFAWMpmlfADLGCIVGGYLPPLFQRwfgvnlivSRKMVVTM 308
Cdd:cd17345 238 IANvFVYLVRYGILD-WAPTYLSEVKGFSKAQamwaFSLFEWA----AIPGTLLAGWLSDKLFK--------GRRAPTGI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 309 GALLMIGPGMIGLFTSPY---IAIALLCVGG--FAHQALSGALITlssDVFGRNEVATANGLTGMSAWLASTLFA-LVVG 382
Cdd:cd17345 305 IFMILVIVALIVYWLAPNvlvDLIALIALGFliYGPVMLIGLQAL---ELVPKKAAGTAAGLTGLFGYLGGSVLAtALIG 381
|
410 420
....*....|....*....|....
gi 1347933230 383 ALADTIGFSPLFAVLAVFDLLGAL 406
Cdd:cd17345 382 IIVDHFGWNGGFIVLLASCILAII 405
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
12-407 |
2.97e-21 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 94.54 E-value: 2.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGA 91
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 92 TALAGSWG--GLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFII 169
Cdd:cd17380 81 TPLLAYSSlpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 170 SGALSFIWAMCWLVFYkhprdqkklsdeerdyilngqesqhknstakkmslgqilrnRQFWGIALPRFLAepAWGTFN-- 247
Cdd:cd17380 161 FGLLGLLWALVWLIYL-----------------------------------------PPVWAIIVAHFCM--NWGFYIll 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 248 AWIPLFmFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwFGVNLIVSRKMVVTMGallMIGPGM----IGLFT 323
Cdd:cd17380 198 SWLPTY-FHEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLIS-RGWTVTSVRKLMQSIG---FLGPALflllLSHTD 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 324 SPYIAIALLCVG-GFAHQALSGALITLsSDVFGRNEVATAnGLTGMSAWLASTLFALVVGALADTIG-FSPLFAVLAVFD 401
Cdd:cd17380 273 SFSLALLCMSVAlGLSAFSSSGVLVNH-QDIAPNYAGIVF-GISNTAGTIPGIVGVYLTGYILEATGsWSLVFVLAAVVN 350
|
....*.
gi 1347933230 402 LLGALV 407
Cdd:cd17380 351 LVGAVV 356
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-411 |
4.87e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 94.17 E-value: 4.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGA 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 92 TALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGaMIAPPLVVWAIVMHSWQMAFIISG 171
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLG-IAVGPLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 172 ALSFIWAMCWLVFYKHPRDQKKLSdeerdyilngqesqhknSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSS-----------------SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnliVSRKMVVTMGALLM-IGPGMIGLFTSPYIAIA 330
Cdd:cd17474 223 FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR---------FGARRILVIGLLLYaLSLLLLGFVPSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 331 LLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
.
gi 1347933230 411 V 411
Cdd:cd17474 374 L 374
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
43-388 |
6.70e-21 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 94.42 E-value: 6.70e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 43 STQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK--IGYAMF--AVLWAVFCGATALAGSWggLALARGAVGAAEAAMIPA 118
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKwsIGIGMFlsSVISIVIPWAAGGGIAL--VVFCRVIQGLAQGSVSPA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 119 GLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVW-AIVMHSWQMAFIISGALSFIWAMCWLVF-YKHPRDQKKLSD 196
Cdd:TIGR00894 152 THKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWlCESWGGWPMIFYVFGIVGCAWSLLWFVFpADDPSIHPCISK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 197 EERDYIlNGQESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFA 276
Cdd:TIGR00894 232 FEKKYI-NSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFA 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 277 DLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSP--YIAIALLCV-GGFAHQALSGALItLSSDV 353
Cdd:TIGR00894 311 WLCSIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAafYLTIIILTLaNAVSSGPLAGVLI-NSLDL 389
|
330 340 350
....*....|....*....|....*....|....*
gi 1347933230 354 FGRnevatANGLTGMSAWLASTLFALVVGALADTI 388
Cdd:TIGR00894 390 APR-----FLGFIKGITGLPGFIGGLIASTLAGNI 419
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
16-409 |
2.05e-20 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 92.30 E-value: 2.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 16 TLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALA 95
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 96 GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGY----FNVGSSIGAMIAPPLVvwaiVMHSWQMAFIISG 171
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIrqtgVPLGGALAAALLPPLA----LHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 172 ALSFIWAMCWLVFYKHPRDQKklsdeerdyilngqeSQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17475 158 LVSILAAVLFWLFYREPPAAS---------------AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPplfQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYIAIAL 331
Cdd:cd17475 223 LFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVS---DRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1347933230 332 LCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17475 300 LILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-412 |
5.85e-20 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 90.80 E-value: 5.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKigyaMFAVLWAV 87
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIR----RFMSAGLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGG----LALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSW 163
Cdd:cd17312 77 LSALANIFMGFSTslwfFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 164 QMAFIISGALSFIWA-MCWLVFYKHPRdqkklsdeerdYIlngqesqhknstakkmslgqilrnrqfWGIALPRFLAEPA 242
Cdd:cd17312 157 RAAFLVPGIVGLVVAiILFFFLRDSPP-----------YV---------------------------WVLSLAYAFVYIV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 243 WGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPplfQRWFGVNlivSRKMVVTMGALLMIGPGMIGLF 322
Cdd:cd17312 199 RYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLS---DKLFGGR---RAPIAVIYMLLMTLSLALFWFF 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 323 -TSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVA-TANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVF 400
Cdd:cd17312 273 pHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAgTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISA 352
|
410
....*....|..
gi 1347933230 401 DLLGALVIWTVL 412
Cdd:cd17312 353 ALLSVLLLLSLW 364
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-409 |
2.10e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 89.15 E-value: 2.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAEA 113
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIwAMCWLVFYkhprdqkk 193
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL-AALLLWRL-------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 194 lsdeerdyiLNGQESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFawmpM 273
Cdd:cd17324 174 ---------LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL----L 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 274 LFADLGCIVGGylpPLFQRWfgVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDV 353
Cdd:cd17324 241 LLFGVAGVVGS---PLAGRL--ADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1347933230 354 FGRNeVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17324 316 APEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-409 |
2.86e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 85.69 E-value: 2.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAV 108
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 109 GAAEAAMIPAGLKASSEwFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIV---MHSWQMAFIISGALSFIWAMCWLVFY 185
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAlfgGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 186 KHPRDQKKLSDEERDYilngqesqhKNSTAKKMSLgqilrnrqFWGIALPRFLAEPAWGTFnawIPlFMFKVYGFNLKEI 265
Cdd:cd17478 174 KPEAKKAAAKSSARST---------LKGVWRALLL--------LLIIVFLRSWVLSSLTTF---LP-FYLVQRGYSLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 266 AMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGA 345
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRF----------GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPV 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1347933230 346 LITLSSDVFGRNeVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17478 303 TVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-415 |
7.61e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.92 E-value: 7.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 168 IISGALSFIWAMCWLVFYKHPRdqkklsdeerdyilngqesQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFN 247
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRP-------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 248 AWIPLfMFKVYGFNLkeiAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVnlivsRKMVVTMGALLMIGPGMIGLFTSPYI 327
Cdd:COG2807 236 AWLPP-ILRDAGLSA---ATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-----RPLLLLLGLLGLAGLLGLLLAPGSLP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 328 AIALLCVgGFAHQALSGALITLSSDVFGR-NEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFDLLGA 405
Cdd:COG2807 307 WLWAVLL-GLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAALLLLAALAVLML 385
|
410
....*....|
gi 1347933230 406 LVIWTVLQNK 415
Cdd:COG2807 386 VAGLLAGRPY 395
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-370 |
4.76e-17 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 82.68 E-value: 4.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLM-EELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMkEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIApPLVVWAIV-------M 160
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLAYGVFkilgvggL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 161 HSWQMAFIISGALSFIWAMcwLVFYKHPRDQKK---LSDEERDYILNGQESQHKNSTAKKMSLGQI---LRNRQFWGIAL 234
Cdd:cd17327 163 AGWRWLFIIEGLITIIIGL--VIFFWLPDNPSKawfLTEEEKELAVERLRANQTGKGDQKFKWKQIkeaFKDPRTWLLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 235 PRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQrwfgvnlivsRKMVVTMGALLMI 314
Cdd:cd17327 241 FFFCSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFK----------KRGLFAIFACVLA 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1347933230 315 GPGMIGLFTSP-----YIAIALLCVGGFAHQALSGALItlSSDVFGRNEVATANGLTGMSA 370
Cdd:cd17327 310 LVGSIILLAAPnppgaYFAAYILGGGSYAGFPILLSWI--SSNCAGYTKRATVLAIMLIFY 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-177 |
1.43e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 76.77 E-value: 1.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|
gi 1347933230 168 IISGALSFIW 177
Cdd:COG0477 172 LINAPLGLLA 181
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-409 |
4.13e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 73.40 E-value: 4.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALS 174
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 175 FI-WAMCWLVFYKHPRdqkklsdeerdyilngqesqHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:cd17489 161 LLaLLLVFLVKDPPPV--------------------AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 254 MFKVygfNLKEIAMFawmpMLFADLGCIVGGYLPPLFQRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYIAIALL 332
Cdd:cd17489 221 AAER---GISNAGLF----FTVYAIALLLSRPFSGKLSDRKG------PKTVIIPGLLLLaLGLLLLSFAGSPWMLLLAA 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1347933230 333 CVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17489 288 VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-411 |
4.85e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 73.07 E-value: 4.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 36 LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAEAAM 115
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 116 IPAGLKAS-SEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAM-CWLVFYKHPRDQKK 193
Cdd:cd17355 109 LAAVAFATvAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVpVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 194 LSDEERDYILNGqesqhknstakkMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPM 273
Cdd:cd17355 189 RAYDDASPASPG------------STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAAAAVALALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 274 LFADLGCIVGGYlppLFQRWFgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVG-GFAHQALSGALITLSSD 352
Cdd:cd17355 256 LFNIVGRLLSGW---LGDRYS------PRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGATVPLTAALAAR 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 353 VFGRNEVATANGLTGMSAWLASTLFALVVGALADTIG-FSPLFAVLAVFDLLGALVIWTV 411
Cdd:cd17355 327 YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
14-410 |
2.15e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 71.13 E-value: 2.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 14 LVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATA 93
Cdd:cd17341 3 LSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 94 LAG-SWGGLALARGAVGAAeAAMIPAGLKASSEWFPAKER----SIAVGYFNVGSSIGAMIAPPLVVWAIVMHS---WQM 165
Cdd:cd17341 83 LAVsSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIggaaGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGfvgWRN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 166 AFIISGALSFIWAMCWLVFYKHPRDQKKLSDEERDYILNGqesqhknstakkmslgqiLRNRQFWGIALPRFLAEPAWGT 245
Cdd:cd17341 162 AFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAV------------------LKNYRTWILSLLYGVTFGSFVG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 246 FNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLF--QRWFGVNLIVsrkMVVTMGALLMIGPGMIGLFT 323
Cdd:cd17341 224 FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFggRRRLWWLFIV---MTIGAALLSLSLPTSGTNLV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 324 spyIAIALLCVGGFAHQALSGALITLSSDVFgRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPL-FAVLAVFDL 402
Cdd:cd17341 301 ---LFLALFVALGLGAGAGNGSVFRMVPFIF-RRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGaFSLFGVLAV 376
|
....*...
gi 1347933230 403 LGALVIWT 410
Cdd:cd17341 377 ACTLLVWL 384
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
8-411 |
6.84e-13 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 69.56 E-value: 6.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAG-LKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMA 166
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITpVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 167 FIISGALSFIWAMCWLVFYKHPRDQKKlsDEERDYILNGQESQHKNSTAKKMslgqiLRNRQFWGIALPRFLAEPAWGTF 246
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLIRDPPKGWV--PPGVDPLANNAENSPRDYTPREM-----LRTPTFWLLWLMFFLNATAGLML 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 247 NAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnlivSRKMVVTMgALLMIGPGMIGLFTSPY 326
Cdd:cd17353 233 IGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI----------GRKNTLSI-AFLIQGVAMFLLPFIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 327 IAIALL---CVGGFAHQALSGALITLSSDVFGRNEVATANGLTgMSAWLASTLFA-LVVGALADTIGFSPLFAVLAVFDL 402
Cdd:cd17353 302 VAVLFVlgvALIGFCYGGGFALFPALTADFFGTKNAGTNYGLL-YTAKGVGGLIGpIIAAYVLYTGGYNAAFIIAAALSL 380
|
....*....
gi 1347933230 403 LGALVIWTV 411
Cdd:cd17353 381 VALALALLL 389
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-176 |
1.68e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 68.37 E-value: 1.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS---G 171
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINlpiG 160
|
....*
gi 1347933230 172 ALSFI 176
Cdd:cd17503 161 ILALL 165
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-412 |
2.55e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 67.97 E-value: 2.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS---G 171
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINvpiG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 172 ALSFIWAmcwlvfykhprdqkklsdeerdyilngqesqhknstakkmslgqilrnRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17321 161 LVALLLA------------------------------------------------RTFSGAVLAAFLLGAALGGLLFLLP 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 252 LFMFKVYGFNLKEIAMFawmpMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIgpGMIGLFTSPYIAIAL 331
Cdd:cd17321 193 LYLQGVLGYSPLQAGLA----LLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLL--ALLGADSSVWLLLPG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 332 LCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGM-------------SAWLASTLFALVVGALADTI---------- 388
Cdd:cd17321 267 LVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTarqlggalgvallGALLTAGLSANLGDSGVAALlsaaaaafaa 346
|
410 420
....*....|....*....|....
gi 1347933230 389 GFSPLFAVLAVFDLLGALVIWTVL 412
Cdd:cd17321 347 GFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-409 |
1.33e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 62.62 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELhiSTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIG----YAMFAVLWAV 87
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF--SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGrkkaLILTLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPpLVVWAIVMH-----S 162
Cdd:cd17316 79 ATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAA-LVASLLIPLlsgdwG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 163 WQMAFIISGALSFIwamcwlvfykhprdqkklsdeerdyilngqesqhknstakkmslGQILRNRqFWGIALPRFLAEPA 242
Cdd:cd17316 158 WRILFLIGALPALL--------------------------------------------ALLLRRR-TLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 243 WGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYlppLFQRWfgvnlivSRKmVVTMGALLMIGPGMIGLF 322
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGL---LSDRI-------GRK-KTLVIGLILSGILALPLF 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 323 ----TSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLA 398
Cdd:cd17316 262 yllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALIL 341
|
410
....*....|.
gi 1347933230 399 VFDLLGALVIW 409
Cdd:cd17316 342 ALLAIVALIVA 352
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-364 |
1.80e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.37 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVF 88
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 89 CGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFI 168
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 169 ISGALSFIWAMCWLVFYKHPRD--QKKLSDEERDYILNGQESQHKNSTAKKMSLGQilRNRQFWGIALPRFLAEPAWGTF 246
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRFLPESIDflVSKRPETVRRIVNAIAPQMQAEAQSALPEQKS--TQGTKRSVFKALFQGKTARITV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 247 NAWIPLFM--FKVYGFNlkeiamfAWMPMLFADLG------------CIVGGYLPPLFqrwFGVNLIVSRKMVVTMGALL 312
Cdd:TIGR00895 254 LLWLLYFMllVGVYFLT-------NWLPKLMVELGfslslaatggalFNFGGVIGSII---FGWLADRLGPRVTALLLLL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1347933230 313 --MIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANG 364
Cdd:TIGR00895 324 gaVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVG 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-189 |
5.09e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.65 E-value: 5.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 9 WYMIALVTLGTVLGYLTRNTVAAAAPT-LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLG--TKIGYAMFAVLW 85
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 86 AVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQM 165
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|....
gi 1347933230 166 AFIISGALSFIWAMCWLVFYKHPR 189
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
225-426 |
2.60e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.74 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 225 RNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKM 304
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLA-EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP---------RRV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 305 VVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGAL 384
Cdd:COG2223 73 LLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL 152
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1347933230 385 ADTIGFSPLFAVLAVFDLLGALVIWTVLQNKSASEVESASQT 426
Cdd:COG2223 153 IAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS 194
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-410 |
3.39e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.39 E-value: 3.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 38 EELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAEAAMIP 117
Cdd:cd17329 28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 118 AGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWaIVMHSWQMAFIIsGALSFIWAMCWLVFYKHPRDQKKLSDE 197
Cdd:cd17329 108 ASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-LLLYSFRLLFLA-AAVLFLLAALVLLFLLPETRPKRRAAE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 198 ErdyilngqesqhknsTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKeiaMFAWMPMLFAD 277
Cdd:cd17329 186 K---------------TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES---LLGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 278 LGCIVGGYLPPLFQRWfgvnlivSRKMVVTMGALLM-IGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGR 356
Cdd:cd17329 248 LIVLLQFPVARLVERF-------RLRKILMIGILLFaIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1347933230 357 NEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd17329 321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
15-409 |
6.88e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 57.19 E-value: 6.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 15 VTLGTVLGYLTRNTVAAAAPTLMEELHiSTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS---G 171
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINlpiG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 172 ALSFIWAmcwlvfykhprdqkklsdeerdyilngqesqhknstakkmslgqilrnRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17502 160 GLALALL------------------------------------------------RTILLSSIFGFLFGGALFGLIYYLP 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYlppLFQRWFGV-NLIVSRKMVVTMGALLMIgpgMIGLFTSPYIAIA 330
Cdd:cd17502 192 LYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGA---LISKTGRYkPLIVIGTILMSVGAGLLT---TLTLDTSKWLLIG 265
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1347933230 331 LLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFalvvgaladtIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17502 266 YLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG----------VAITDVFLVALALAALAFLLSL 334
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
10-386 |
1.10e-08 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 56.98 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 10 YMIALVTLGTVlgYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK-------IGYAMFA 82
Cdd:PRK09556 31 YLVVFIGYLTM--YLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKqflpfllILSAICM 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 83 VLWAVFCGATALagSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVW-AIVMH 161
Cdd:PRK09556 109 LGFGASLGSGSV--SLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWgANYFF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 162 SWQMA--FIISGALSFIWAMcWLVFYKHprdqkklsDEERDYILNGQE--------SQHKNSTAKKMSLGQI-----LRN 226
Cdd:PRK09556 187 DGHVIgmFIFPSIIALIIGF-IGLRYGS--------DSPEELGWGKAEeifgepisEEDKETESTDMTKWQIfveyvLKN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 227 RQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNlKEIAMfawMPMLFADLGCIVG----GYLPplfqrwfgvNLIVSR 302
Cdd:PRK09556 258 PVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFS-KEDAI---NTFTLFEIGALVGsllwGWLS---------DLANGR 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 303 KMVVTMGALLMIGpGMIGLF---TSPYIAIALLCVGG---FAHQALSG-ALITLSSdvfgRNEVATANGLTGMSAWLAST 375
Cdd:PRK09556 325 RALVACIALALII-FTLGVYqhaTSEYMYLASLFALGflvFGPQLLIGvAAVGFVP----KKAIGVANGIKGTFAYLFGD 399
|
410
....*....|..
gi 1347933230 376 LFALV-VGALAD 386
Cdd:PRK09556 400 SFAKVgLGMIAD 411
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-409 |
2.10e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.06 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 60 VMQPVAGYVLDVLGTKIGYAMF-----AVLWAVFCGATALAGSWGG------LALARGAVGAAEAAMIPAGLKASSEWFP 128
Cdd:COG2211 61 ITDPLIGALSDRTRTRWGRRRPwiligAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 129 -AKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM------HSWQMAFIISGALSFI--WAMCWLVFYKHPRDQKKLSdeer 199
Cdd:COG2211 141 dYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLafLLTFFGTKERPVPEEEKVS---- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 200 dyilngqesqhknstaKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLkeiAMFAWMPMLFAdLG 279
Cdd:COG2211 217 ----------------LKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSA---ALVGLLLALYF-LA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 280 CIVGGYLPPLFQRWFGvnlivsRKMVVTMGALLMIGpGMIGLF----TSPYIAIALLCVGGFAHQALSGALITLSSDV-- 353
Cdd:COG2211 277 ALLGAPLWPRLAKRFG------KKKAFIIGLLLAAL-GLLLLFflgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVvd 349
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1347933230 354 -----FGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSP---------------LFAVLAVFDLLGALVIW 409
Cdd:COG2211 350 ydewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirllFFLLPAVLLLLAALLLL 425
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
8-226 |
3.86e-08 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 55.03 E-value: 3.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK-------IGYAM 80
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARwlfssglVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 81 FAVLWAVFCGATALAGSWGGLALARGAVGAAEAAMipagLKAsseWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKI----LRK---WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALS 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1347933230 161 HSWQMAFIISGALSFIWAMCWLVFykhprdqkkLSDEERDYILNGQESQHKNSTAKKMSLGQILRN 226
Cdd:cd17343 154 YGWRSTLSISGTVAVVMSVVCLLF---------IKNEPSDVGLNNIEEEESKGKKKKSPRGESTLK 210
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-185 |
3.96e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 54.89 E-value: 3.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGA 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 92 TALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISG 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|....
gi 1347933230 172 ALSFIwamCWLVFY 185
Cdd:cd17323 161 IISGF---CLILIF 171
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
81-408 |
4.55e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 54.62 E-value: 4.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 81 FAVLW-AVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIA----PPLVV 155
Cdd:cd17371 69 ITILLfAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLAtllaALLFP 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 156 WAIVMHSWQMAFIISGALSFIwamCWLVfykhprdQKKLSDEERdyilnGQESQHKNSTAKKMSLGQILRNRQFWGIALP 235
Cdd:cd17371 149 LLPPEIAWRVLFLLGALPALL---VLFI-------RRFVKEPPQ-----WQAARAARRHFADRPSLRELFSPPLLRTTLL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 236 RFL----AEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKMVVTMGAL 311
Cdd:cd17371 214 ASLlatgALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGR---------RNNFALFALG 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 312 LMIG-PGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGF 390
Cdd:cd17371 285 SAISiLLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSL 364
|
330
....*....|....*...
gi 1347933230 391 SPLFAVLAVFDLLGALVI 408
Cdd:cd17371 365 GTAIAVFAAVYYIAGLVL 382
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-173 |
7.45e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.13 E-value: 7.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAV 108
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1347933230 109 GAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGAL 173
Cdd:cd17365 98 GLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVP 162
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-182 |
9.44e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.76 E-value: 9.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLMEE-LHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGL--KASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIV-MHSWQ 164
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAlyAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAsTGGTG 335
|
170
....*....|....*...
gi 1347933230 165 MAFIISGALSFIWAMCWL 182
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
9-408 |
1.03e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 53.78 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 9 WYMIALVTLGTVLGYLTRNTVAaaaPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIG----------- 77
Cdd:cd17313 1 LFLLGFGFFGIEFGWALENSYV---PPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGrrrpfilvgap 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 78 ---YAMFAVLWA-VFCGATALAGSWGGLALARGAVG----AAEAAMIPAglKA-SSEWFPAKERSIAVGYFN-------- 140
Cdd:cd17313 78 laaLGLILIPNAaDIGLALGDGPRTWALVLFVLGIVlldfAMNVCQGPV--RAlLPDLVPPEQRSKANGIINfmgglggv 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 141 VGSSIGAMIAPPLVVWAIVMHSWQMAFIIsGALSFIWAMCWLVFYKHPRDqkklsdeerdyiLNGQESQHKNSTAKKMSL 220
Cdd:cd17313 156 LGYLLGAILWDHNWFGFALGGNLKVPFYI-GAIILLVCVLVTLFFVKEPP------------LSPEAGEHSENPSLGEVL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 221 GQILR-----NRQFWGIALPRFLAEPAWGTFNAWIPLFM-FKVYGFNLKEIA-------MFAWMPMLFAdLGCIVGGYLP 287
Cdd:cd17313 223 KSLLKllkimPRSLLRLLLVIFFWWIAFFPFELFFTDYMgEEVYHGTSAASShygagvrMGAWGLLIFS-LAFLIFSLPI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 288 PLFQRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYIAIALLCVGGF---AHQALSGALITLSSDVFGRNEvATAN 363
Cdd:cd17313 302 GKLGKKIG------RKKVYLIGLVLFaVGMALMALVHNVTVALVLFALGGIgwaTININPYPLVSDYHSESGRGQ-GTDT 374
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1347933230 364 GLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVI 408
Cdd:cd17313 375 GLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGA 419
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
49-391 |
2.43e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 52.47 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 49 YIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGG--LALARGAVGAAEAAMIPAGLKASSEW 126
Cdd:cd17381 69 WILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMHAMWASW 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAMCWLVFYkhprdqkklsdeerdyilngq 206
Cdd:cd17381 149 APPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 207 esqhknstakkMSLgqilrnrqfWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYL 286
Cdd:cd17381 208 -----------MPL---------WAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 287 PPLFQRWFGVNLIVSRKMVVTMGallMIGPgmiglftspyiAIALLCVG--------GFAHQALSGALITLSSDVFGRNE 358
Cdd:cd17381 268 ADNLREKQNFSTVCVRKIFTLIG---MIGP-----------AVFLLAAGftgcnyslAVAFLTISSTLGGFSASGFNINH 333
|
330 340 350
....*....|....*....|....*....|...
gi 1347933230 359 VATANGLTGMSAWLASTlFALVVGALADTIGFS 391
Cdd:cd17381 334 LDIAPSYAGILLGITNT-FATIPGMVGPVIAKS 365
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
127-409 |
4.36e-07 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 51.84 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIisgALSFIWAMCWLVFYKHprdqkklsdeeRDYILNGQ 206
Cdd:cd17485 121 LTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLL---SLAALYLLLLLPVLFL-----------RELELPQQ 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 207 ESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKvYGFNLKEIAM-FAWMPMLFADLGCIVGGY 285
Cdd:cd17485 187 PPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVD-RGFSLSQIGLlSGVGGSLVSIAGSLLGGY 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 286 LpplFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGL 365
Cdd:cd17485 266 L---LKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTL 342
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1347933230 366 TGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17485 343 LATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
23-411 |
4.43e-07 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 51.89 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 23 YLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLD-VLGTKIG---YAMFAVLWAVFCGATALAGSW 98
Cdd:cd17340 12 YFCYDNPAALQKQFIEDMDINTSQFMLLYSVYSWPNVVLCFFGGFLIDrVFGIRLGtiiFSLLVLIGQLIFALGALTNLF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 99 GGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIA----VGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALS 174
Cdd:cd17340 92 WLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVfglqLSFARIGSTVNFNVMPPIYKRISDFYSGYKSLGVALWIG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 175 FIWAM----CWLVFykhprdqkKLSDEERDYILNGQEsqhkNSTAKKMSLGQILR-NRQFWGIALPRFLAEPAWGTFNAW 249
Cdd:cd17340 172 AITCLfsliCAIIL--------GLLDKRAERILKKES----NKTGEVIKLSDVKDfPLSFWLICIICVFYYVAVFPFIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 250 IPLFMFKVYGFNLKEIAmfAWMPMLFadlgcIVGGYLPPLFQrwFGVNLIVSRKMVVTMGALLMIGPGMIGLFTS--PYI 327
Cdd:cd17340 240 GTVFFEEKYGFSPSEAA--AVNSIVY-----IISAAASPVFG--FLVDKVGRNILWVLIALVITLLGHLLLAFTFvnPLI 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 328 AIALLcvgGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPL---FAVLAVFDLLG 404
Cdd:cd17340 311 AMVIM---GIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLevfFIACLCVSLIA 387
|
....*..
gi 1347933230 405 ALVIWTV 411
Cdd:cd17340 388 LIILYLV 394
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-412 |
5.23e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 218 MSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvn 297
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 298 livsRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLF 377
Cdd:COG2814 75 ----RRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
|
170 180 190
....*....|....*....|....*....|....*
gi 1347933230 378 ALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVL 412
Cdd:COG2814 151 PLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
32-410 |
6.85e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.08 E-value: 6.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 32 AAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK----IGYAMFAVLWAVFCGATALAG-SWGGLALARG 106
Cdd:cd06173 21 ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrlliLADLLRALLAAVLALLALLGSlSLWLLLVLAF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 107 AVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFI-WAMCWLVFY 185
Cdd:cd06173 101 LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLsALLLLFIRR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 186 KHPRDQKKLSDEERDYILNGqesqhknstakkmsLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLkei 265
Cdd:cd06173 181 PPPAAPGESSSLLLRDLREG--------------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA--- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 266 AMFAWMPMLFAdLGCIVGGYLPPLFQRWFGvnlivSRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGA 345
Cdd:cd06173 244 AGYGLLLAAFG-VGALLGALLLGRLSKRRR-----RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1347933230 346 LITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-356 |
1.07e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.40 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 24 LTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGyAMFAVLWAVFCGATALAGSWGGLAL 103
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRT-LILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 104 ARG-----AVGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIvmhSWQMAFIISGALSFIWA 178
Cdd:cd17333 89 VLMflaglGAGILDTGANTFVGALFEESSATR-LNVLHGFFGLGALIGPLIATSLLTSEL---SWSWAYLIIGLIYLLLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 179 MCWLVFYKHPRDQKKLSDeerdyilngqesqhKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVY 258
Cdd:cd17333 165 ILILLTLFPELPSARNPQ--------------QSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 259 GFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFA 338
Cdd:cd17333 231 HVSDGLAGYLLSGFWVGITIGRLLGGPI---------SRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLF 301
|
330
....*....|....*...
gi 1347933230 339 HQALSGALITLSSDVFGR 356
Cdd:cd17333 302 MAALFPTILSLGISNLPY 319
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
237-431 |
2.57e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 2.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 237 FLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGP 316
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL---------SDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 317 GMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAV 396
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190
....*....|....*....|....*....|....*
gi 1347933230 397 LAVFDLLGALVIWTVLQNKSASEVESASQTGDPAA 431
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI 191
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
130-409 |
3.46e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 49.14 E-value: 3.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 130 KERSIAVGYFNVGSSIGAMI----APPLVVWA---IVMHSWQMAFIISGALSFIWAMcWLVFYKHPRDqkklsdeerdyi 202
Cdd:cd17332 132 EERTSLTSWRMFFATIGGLLvtvlPPPLVAYFgggNASRGYFLTALIIGIIGIILLL-ICFFGTRERV------------ 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 203 lNGQESQHKNSTAKKmSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFmfkvYGFNLKEIAMFAWMPMLFAdLGCIV 282
Cdd:cd17332 199 -VPPEEEKSKLPLLK-SLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYY----FKYVLGGRAELVLLLLLIL-SGALL 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 283 GGYLPPLFQRWFGvnlivsRKMVVTMGALLMIgPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLS----SDV----- 353
Cdd:cd17332 272 ALLPWPPLKKRFG------KKKAFFIGLLLAI-LGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPwamlADVidyge 344
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1347933230 354 --FGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSP---------------LFAVL-AVFDLLGALVIW 409
Cdd:cd17332 345 lkTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVAnaaaqsasalngirlLIAVLpAVLLLLALILMS 418
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-409 |
4.35e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.73 E-value: 4.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGA 91
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 92 TALAGSWGGLALAR---GAVGAAEAAMIPAGLKASsewFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFI 168
Cdd:cd17320 81 CALASSIEQLLIARflqGLGAAAGSVVARAIVRDL---YSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 169 ---ISGALSFIWAMCWLvfyKHPRDQKKLSDEERDYILNgqesqhknstakkmsLGQILRNRQFWGIALPRFLAEPAWGT 245
Cdd:cd17320 158 flaLLGLLLLLLVLLFL---PETLPEEKRKPLLSSLLRA---------------YKRVLKNRRFLGYALALGLSFAGLFA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 246 FNAWIPLFMFKVYGFNlkeIAMFAWMpMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSP 325
Cdd:cd17320 220 YLAAAPFIYIEQLGLS---PAQFGLL-FALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 326 YIAIALLCVGGFAHQALSGALITLSSDVFGRnEVATANGLTGMSAWLASTLFALVVGALADTiGFSPLFAVLAVFDLLGA 405
Cdd:cd17320 296 WPLVAPLFLIFFGFGLIFPNATSLALEPFPH-VAGTASALLGFLQFLIGALAGALVGLLPNG-TALPMGLLILVLGLLAL 373
|
....
gi 1347933230 406 LVIW 409
Cdd:cd17320 374 LLLI 377
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
63-185 |
4.65e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 48.35 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 63 PVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVG 142
Cdd:cd17317 43 LLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLF 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1347933230 143 SSIGAMIAPplvVWAIVMHSWQM-AFIISG-----------------ALSFIWAMCWLVFY 185
Cdd:cd17317 123 WALGYMLLA---LLAYLIRDWRWlQLAISLpgllfllllwwlprrtiIVGLIWFVTSLVYY 180
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
8-407 |
4.80e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 48.56 E-value: 4.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 FCGATALAGSWGGLALARGA-VGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMA 166
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVfIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 167 FIISGALSFIWAMCWLVF-YKHPRDQKKLSDEERDYILNgqesqhknstakkmsLGQILRNRQFWGIALPRFLaepawgT 245
Cdd:cd17314 160 YTILGILAAIVLSVVSLLgFKEPPDNQARLHVQKKKTQT---------------MGEIFRDKVFWILFIAIFL------V 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 246 FNAWIPLFMFKV-YGFNLKEIAMFAWMPML-FADLGCIVGGYLPPLFQRWFGVNLivsRKMVVTMG-ALLMIGPGMIGLF 322
Cdd:cd17314 219 LIGGFLFIANMAsLVRSLQLDAPSFVTKLMsIYGLFNAFGRLLWGIVADFFGGRL---STLSILLTiLGLGLCAFLFLLK 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 323 TSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFD 401
Cdd:cd17314 296 MTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDrTPSYISAVYIYAVIV 375
|
....*.
gi 1347933230 402 LLGALV 407
Cdd:cd17314 376 FLASAI 381
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
34-411 |
5.50e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 48.37 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARgAVGAAEA 113
Cdd:cd17331 24 PYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 114 AMiPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIwamCWLVFYKHPRDQKK 193
Cdd:cd17331 103 AM-QAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLL---SIVLVILLIPSNTK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 194 LSDEERDyilngQESQHKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFawMPM 273
Cdd:cd17331 179 SKREKEA-----KESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYL--MSY 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 274 LFAdLGCIVGGYLPPLFQRWFGvnlivSRKMVVTMGALLMIGPGMIGLFTSPYIAIAL---LCVGGFAHQALSGALITLS 350
Cdd:cd17331 252 AGV-LGMVVQGLLVGPLTKRFG-----ERSLLKLSVALLAIGYLLLAFVTTVWQLLVLllpLVIGGSVLYTVITSLLTKA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1347933230 351 SDvfgRNEVATANGLTGMSAWLASTLFALVVGALADTIGFsPLFAVLAVFDLLGALVIWTV 411
Cdd:cd17331 326 VP---PEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF-PSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
30-204 |
1.08e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 47.62 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 30 AAAAPTLMEELHISTQqYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVG 109
Cdd:cd06179 18 AAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 110 AAeAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPpLVVWAIVMH---SWQMAFIISGALSFIWAMCWLVFYK 186
Cdd:cd06179 97 IG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGP-LIAGALVEAnaaGWRWIFYINAIFNALALILLFFFYH 174
|
170
....*....|....*...
gi 1347933230 187 HPRDQKKLSDEERDYILN 204
Cdd:cd06179 175 PPPRPQLHGSSTRQKLKR 192
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-184 |
1.62e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 3 KIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHI-STQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMF 81
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 82 AVLWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM- 160
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLt 349
|
170 180
....*....|....*....|....
gi 1347933230 161 HSWQMAFIISGALSFIWAMCWLVF 184
Cdd:cd17473 350 GGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
29-184 |
2.08e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 46.49 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAV 108
Cdd:cd17476 17 VIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQ 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1347933230 109 GAAEAAMIPAGLKASSEWF-PAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWA-MCWLVF 184
Cdd:cd17476 97 GLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAvAAIFWT 174
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
93-412 |
3.52e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 3.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 93 ALAGSWGGLA-------LARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIApPLVVWAIVMHSWQM 165
Cdd:cd17473 76 GIGGVAGLFLdslyallASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVF-LLLGGALAEIGWRA 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 166 AFIISgALSFIWAMCWLVFYKHPRdqkklsdeerdyilngQESQHKNSTAKKMSlgQILRNRQFWGIALPRFLAEPAWGT 245
Cdd:cd17473 155 PFLVY-LLALPVLILVLLFLPEPA----------------RKSKSAASPGAATA--AALPWKRVLPIYFLAFLAMLLFYV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 246 FNAWIPLFMFKVYGFNLKEIAMFAWMPMLFAdlgcIVGGYLPPLFQRWFGVnlivsRKMVVTMGALLMIGPGMIGLFTSP 325
Cdd:cd17473 216 IPIQLPFLLQERGGGSAALIGLALAIASLAG----AIGALLFGRLKRRLGK-----RRLLAIGFALMALGFLLLALASGL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 326 YIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTI-GFSPLFAVLAVFDLLG 404
Cdd:cd17473 287 WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVL 366
|
....*...
gi 1347933230 405 ALVIWTVL 412
Cdd:cd17473 367 AIVLLLLR 374
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-176 |
4.75e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.26 E-value: 4.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAV 108
Cdd:cd17504 15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1347933230 109 GAAeAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFI 176
Cdd:cd17504 95 GIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL 161
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
8-406 |
5.03e-05 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 45.09 E-value: 5.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKigYAMFAVLWAV 87
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPR--YFMGIGLIAT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 88 fcGAT----ALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSW 163
Cdd:cd17488 79 --GIInilfGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 164 QMAFIISGALSFIWAMcWLVFykhprdqkKLSDeerdyilngqesqhknstakkmslgqilRNRQFWGIALPRFLAEPAW 243
Cdd:cd17488 157 RAGMYVPGIIAILMGI-VLCW--------RLRD----------------------------RPPYIWLLAFCYVLVYVVR 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 244 GTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLF---QRWfGVNLIVSRKMVVTMGALLMIGPGMIG 320
Cdd:cd17488 200 TAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfkgNRG-PMNLIFALGLLVSVGALWLVPVHSYW 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 321 LftspyIAIALLCVGGFAHQalSGALITLSSDVFGRNEVA-TANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAV 399
Cdd:cd17488 279 L-----LATCFFTIGFFVFG--PQMLIGMAAAECSHKDAAgSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISI 351
|
....*..
gi 1347933230 400 FDLLGAL 406
Cdd:cd17488 352 AAAISGL 358
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-408 |
5.05e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 5.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAEA 113
Cdd:cd17477 20 SLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVvwAIVMHSWQMAFIISGALSFIwamCWLVFYKHPRDQKK 193
Cdd:cd17477 100 GLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLL--ALVGTAGALPFLIAAVLLLL---ALVPLLLTRRAAPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 194 LSDEErdyilngqesqhknstakKMSLGQILRnrQFWGIALPRFLAEPAWGTFNAWIPLFMFKVyGFNLKEIAMFAWMPM 273
Cdd:cd17477 175 IEEAE------------------SISLRRLLR--IAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 274 LFADLGCIVGGYLPPLFQRwfgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDV 353
Cdd:cd17477 234 LGGLLLQWPLGWLADRFDR--------RRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1347933230 354 FGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVI 408
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
37-176 |
8.05e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 8.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 37 MEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK----IGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAE 112
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKklliLGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1347933230 113 AAMipagLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFI 176
Cdd:cd17370 306 SIE----RAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
34-182 |
1.08e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.08 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWA--VFCGATALAGSWGGLALARGAVGAA 111
Cdd:cd17352 207 PSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLIlgLSLLAFPLATTYVGLIVFSVLFGFC 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1347933230 112 EAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM-HSWQMAFIISGALSFIWAMCWL 182
Cdd:cd17352 287 SGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYtGDYDAAFYFCGACLLLSGVLLF 358
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
35-271 |
1.20e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.83 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 35 TLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAG-SWGGLALARGAVGAAEA 113
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 114 AMIPAgLKASSEWFPAKER----SIAVGYFNVGSSIGAMIAPPLVVWAI------VMHSWQMAFIISGALsFIWAMCWLV 183
Cdd:TIGR00886 107 SFASC-MPWISFFFPKKIQgtalGLAAGWGNMGGGVAQFVMPPIIGSLIfgggqpAHLAWGWAFVIVPAG-ILLLPALLI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 184 FY---KHPRDQKklsdeerdyilngqesqhKNSTAKKMSLGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGF 260
Cdd:TIGR00886 185 FFvgaDTPPGKP------------------ATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGL 246
|
250
....*....|.
gi 1347933230 261 NLKEIAMFAWM 271
Cdd:TIGR00886 247 SKVQAGAYASL 257
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
36-184 |
2.03e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.31 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 36 LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAEAAM 115
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGL 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 116 I-PAGLKASSEWFpAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAMCWLVF 184
Cdd:cd17352 109 IySPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL 177
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
80-182 |
3.40e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 42.71 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 80 MFAVLWAVFCG---ATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVW 156
Cdd:cd17382 83 GLAIFVTSTLNmliPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGI 162
|
90 100
....*....|....*....|....*.
gi 1347933230 157 AIVMHSWQMAFIISGALSFIWAMCWL 182
Cdd:cd17382 163 LVQYVGWSSPFYVYGVFGIIWYMFWM 188
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
302-419 |
7.81e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.41 E-value: 7.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 302 RKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVV 381
Cdd:cd17325 61 KRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG 140
|
90 100 110
....*....|....*....|....*....|....*...
gi 1347933230 382 GALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKSASE 419
Cdd:cd17325 141 GLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP 178
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
32-169 |
7.85e-04 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 41.64 E-value: 7.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 32 AAPTLMEELHISTQQYSYIIAAYSaayTVMqpvAGYVLDV--LGTKIGYAMFAVLWAVFCG----ATALAGSWGGLALAR 105
Cdd:PRK14995 28 AAPTLSMTLGASGNELLWIIDIYS---LVM---AGMVLPMgaLGDRIGFKRLLMLGGTLFGlaslAAAFSPTASWLIATR 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1347933230 106 GAVGAAEAAMIPAGLKASSEWF-PAKERSIAVGYFNVGSSIGAMIApPLVVWAIVMH-SWQMAFII 169
Cdd:PRK14995 102 ALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFG-PLVGGILLEHfYWGSVFLI 166
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
17-419 |
1.06e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 41.23 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 17 LGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLD--------------------VLGTKI 76
Cdd:PRK11663 30 LGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDrsnaryfmgigliatgiiniLFGFSS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 77 GYAMFAVLWAvfcgATALAGSWGGlalargavgaaeaamiPAGLKASSEWFPAKER----SIAVGYFNVGssiGAMIapP 152
Cdd:PRK11663 110 SLWAFALLWV----LNAFFQGWGW----------------PVCAKLLTAWYSRTERggwwAIWNTAHNVG---GALI--P 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 153 LVVWAIVMH-SWQMAFIISGALSFIWA--MCWLVfykhpRDQKK------LSDEERDYILNGQESQHKNSTAKKMSLGQI 223
Cdd:PRK11663 165 LVVGAIALHyGWRYGMMIAGIIAIVVGlfLCWRL-----RDKPQamglpsVGEWRHDALELAQQQEGAGLSRKEILTKYV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 224 LRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNL----KEIAMFAwmpmlfadlgciVGGYLPPLFQRW-----F 294
Cdd:PRK11663 240 LLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLvtanSAVSMFE------------LGGFIGALVAGWgsdklF 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 295 G-----VNLIVSRKMVVTMGAL-LMIGPGMIglftspYIAIALLCVGGFAH--QALSGALITLSSDvfgRNEVATANGLT 366
Cdd:PRK11663 308 NgnrgpMNLIFAAGILLSVGSLwLMPFASYV------MQAACFFTIGFFVFgpQMLIGMAAAECSH---KEAAGAATGFV 378
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1347933230 367 GMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKSASE 419
Cdd:PRK11663 379 GLFAYLGAALSGYPLAKVLEIWHWTGFFVVISIAAGISALLLLPFLNAQAPRE 431
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
302-426 |
1.56e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 302 RKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVV 381
Cdd:cd17489 61 KRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALG 140
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1347933230 382 GALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKSASEVESASQT 426
Cdd:cd17489 141 LFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT 185
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-151 |
1.62e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 9 WYMIALVTLGTVLGYLTrntvaAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVF 88
Cdd:pfam07690 204 WLLLALLLFGFAFFGLL-----TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1347933230 89 CGATALAGSWGGLALARGA---VGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAP 151
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLAlllLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
8-155 |
3.28e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 39.69 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWA- 86
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNAl 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1347933230 87 ---VFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIG---AMIAPPLVV 155
Cdd:cd17334 82 gsvLKCIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGcaiGFLLPPVVV 156
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
34-191 |
3.34e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.59 E-value: 3.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLALARGAVGAAEA 113
Cdd:cd06180 23 PLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH-SWQMAFIISGALSFIWA-MCWLVFYKHPRDQ 191
Cdd:cd06180 103 FVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlSWRAGWLALALLSAVLLlLSFLLLRRGPSAP 182
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
300-412 |
6.44e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 38.68 E-value: 6.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 300 VSRKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVG-GFAHQALSGALITLSSDVFGRNEVATANGLTgMSAWLASTLFA 378
Cdd:cd17324 61 IERRRLLLVLLLLFILGNLLAALAPSFALLLLARALaGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLG 139
|
90 100 110
....*....|....*....|....*....|....*
gi 1347933230 379 LVVGA-LADTIGFSPLFAVLAVFDLLGALVIWTVL 412
Cdd:cd17324 140 RPLGGlLGQLLGWRAAFLAIAVLALLAALLLWRLL 174
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
302-411 |
7.02e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 7.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 302 RKMVVTMGALLMIGPGMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVV 381
Cdd:COG0477 79 KRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
90 100 110
....*....|....*....|....*....|
gi 1347933230 382 GALADTIGFSPLFAVLAVFDLLGALVIWTV 411
Cdd:COG0477 159 GLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
7-262 |
7.24e-03 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 38.54 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 7 LRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEElHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKI----GYAMFA 82
Cdd:PRK11273 26 LRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVflpaGLILAA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 83 VLWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM-H 161
Cdd:PRK11273 105 AVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLFLLGMAWfN 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 162 SWQMAFIISGALSFIWAM-CWLVFYKHPRDQKKLSDEE--RDYILNGQESQHKNSTAKKMSLGQILRNRQFWGIALPR-F 237
Cdd:PRK11273 185 DWHAALYMPAFAAILVALfAFAMMRDTPQSCGLPPIEEykNDYPDDYNEKHEQELTAKQIFMQYVLPNKLLWYIAIANvF 264
|
250 260
....*....|....*....|....*
gi 1347933230 238 LAEPAWGTFNaWIPLFMFKVYGFNL 262
Cdd:PRK11273 265 VYLLRYGILD-WSPTYLKEVKHFAL 288
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
34-409 |
8.06e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 8.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLG-----TKIGYAMFAVLWAVFcgatALAGSWGGLALAR--- 105
Cdd:cd17370 23 PLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkrkplVILGYGLSALAKPLL----ALAGSWQLVLLLRile 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 106 ----GAVGAAEAAMIpaglkasSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH--SWQMAFIISGALSFIwAM 179
Cdd:cd17370 99 rlgkGIRTPPRDALL-------ADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLggNYRTIFLLAAIPALL-AL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 180 CWLVFYKHPRDQKKlsdeerdyilngqesqhkNSTAKKMSLGQILRNRQFWGIALPRFLAepAWGTFNAWIPLFMFKVYG 259
Cdd:cd17370 171 LILLFVVKEYPRPP------------------KLRKKSKKTSLKKLPKAFWLYLLAVALF--ALGNFSFAFLILRAQELG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 260 FNLKEIAMFAWMPMLFADLGCIVGGYLpplFQRWfgvnlivSRKMVVTMGALLM-IGPGMIGLFTSPYIAIALLCVGGFA 338
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRL---SDRI-------GRKKLLILGYLSLaLAYLGFALGSSLWLLLLGFILWGLY 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1347933230 339 HQALSGALITLSSDVFGRNEVATANGL----TGMSAWLASTLFalvvGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17370 301 MGAQESIERAAVADLVPAELRGTAYGLfntvVGIGWLLASLIA----GYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
63-189 |
8.86e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.46 E-value: 8.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 63 PVAGYVLDVLGTKIGYaMFAVLW-AVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNV 141
Cdd:TIGR00898 145 FVFGYLSDRFGRKKVL-LLSTLVtAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQV 223
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1347933230 142 GSSIGAMIApPLVVWAIvmHSWQMAFIISGALSFIWAMCWLVFYKHPR 189
Cdd:TIGR00898 224 FFSLGLVLL-PLVAYFI--PDWRWLQLAVSLPTFLFFLLSWFVPESPR 268
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
237-421 |
8.88e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 8.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 237 FLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGP 316
Cdd:cd06174 6 FLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLL---------ADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347933230 317 GMIGLFTSPYIAIALLCVGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD--TIGFSPLF 394
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVF 155
|
170 180
....*....|....*....|....*..
gi 1347933230 395 AVLAVFDLLGALVIWTVLQNKSASEVE 421
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARA 182
|
|
| |
