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Conserved domains on  [gi|1359351530|gb|PRT20265|]
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sigma-M negative effector [Bacillus toyonensis]

Protein Classification

anti-sigma factor( domain architecture ID 18823626)

anti-sigma factor similar to Bacillus subtilis probable anti-sigma-M factor YhdL that negatively regulates sigma-M and is co-transcribed with sigma-M and yhdK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sigma_reg_C pfam13791
Sigma factor regulator C-terminal; This family is the C-terminal domain of a sigma factor ...
 207-365 1.86e-51

Sigma factor regulator C-terminal; This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain.


:

Pssm-ID: 433482  Cd Length: 157  Bit Score: 168.68  E-value: 1.86e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530 207 LAKVHDGTVAEAAISFDKAYTLKELEPLLysifeaQELPPTPVWYALDTGQERKNAEDYILHGGETIGFPEHVRFLGNET 286
Cdd:pfam13791   1 LEKLPEGTVAEVYVSFDKAYSYAEVYKML------KPEDLDLLWYAVDTGDEEKLEGDSFISETPPIGFPGNPSSSIDDF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530 287 DRQKTQEDK-----VIEMMRVLSTHKKTVSKIAALPENElNLDKRYQYVKDNGVKVYGIVITGPSKELLKLQNSPHVRYA 361
Cdd:pfam13791  75 KPKYPDELQnseehFIKLLKYLSDQEDIAKMLNADLLDG-KLDERYKYVKKNGVKIYGVVVTGPTKELLKLEKEPEVKAA 153


                  ....
gi 1359351530 362 TLGD 365
Cdd:pfam13791 154 YVGE 157
Sigma_reg_N pfam13800
Sigma factor regulator N-terminal; This domain is found near the N-terminus of a sigma factor ...
 65-153 5.41e-22

Sigma factor regulator N-terminal; This domain is found near the N-terminus of a sigma factor regulator. The N-terminus is responsible for interaction with the sigma factor.


:

Pssm-ID: 463986  Cd Length: 89  Bit Score: 88.84  E-value: 5.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530  65 RIKWKHRLQTFGFILSICIVIYIIGgVLSAFYFqanNDKRLEEIREVPSLALEATIPNSRVMGGGTSVEAFFRTNSSFDL 144
Cdd:pfam13800   5 KGKRKSRLRIVLISLIVFLLIFVIS-IITALYY---APKRGNELREVIELTVEITSPNVYVDSGVTSQSGFFGGEITYDL 80


                  ....*....
gi 1359351530 145 VRTVGKKEM 153
Cdd:pfam13800  81 SKRVGGKEV 89
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
1-43 8.35e-06

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


:

Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 45.22  E-value: 8.35e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1359351530   1 MGCAEFKKLWEKYENGTLTHDEQEQLESHIETCAECEAHLDEL 43
Cdd:COG5662     1 MTCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAEL 43
 
Name Accession Description Interval E-value
Sigma_reg_C pfam13791
Sigma factor regulator C-terminal; This family is the C-terminal domain of a sigma factor ...
 207-365 1.86e-51

Sigma factor regulator C-terminal; This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain.


Pssm-ID: 433482  Cd Length: 157  Bit Score: 168.68  E-value: 1.86e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530 207 LAKVHDGTVAEAAISFDKAYTLKELEPLLysifeaQELPPTPVWYALDTGQERKNAEDYILHGGETIGFPEHVRFLGNET 286
Cdd:pfam13791   1 LEKLPEGTVAEVYVSFDKAYSYAEVYKML------KPEDLDLLWYAVDTGDEEKLEGDSFISETPPIGFPGNPSSSIDDF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530 287 DRQKTQEDK-----VIEMMRVLSTHKKTVSKIAALPENElNLDKRYQYVKDNGVKVYGIVITGPSKELLKLQNSPHVRYA 361
Cdd:pfam13791  75 KPKYPDELQnseehFIKLLKYLSDQEDIAKMLNADLLDG-KLDERYKYVKKNGVKIYGVVVTGPTKELLKLEKEPEVKAA 153


                  ....
gi 1359351530 362 TLGD 365
Cdd:pfam13791 154 YVGE 157
Sigma_reg_N pfam13800
Sigma factor regulator N-terminal; This domain is found near the N-terminus of a sigma factor ...
 65-153 5.41e-22

Sigma factor regulator N-terminal; This domain is found near the N-terminus of a sigma factor regulator. The N-terminus is responsible for interaction with the sigma factor.


Pssm-ID: 463986  Cd Length: 89  Bit Score: 88.84  E-value: 5.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530  65 RIKWKHRLQTFGFILSICIVIYIIGgVLSAFYFqanNDKRLEEIREVPSLALEATIPNSRVMGGGTSVEAFFRTNSSFDL 144
Cdd:pfam13800   5 KGKRKSRLRIVLISLIVFLLIFVIS-IITALYY---APKRGNELREVIELTVEITSPNVYVDSGVTSQSGFFGGEITYDL 80


                  ....*....
gi 1359351530 145 VRTVGKKEM 153
Cdd:pfam13800  81 SKRVGGKEV 89
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
1-43 8.35e-06

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 45.22  E-value: 8.35e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1359351530   1 MGCAEFKKLWEKYENGTLTHDEQEQLESHIETCAECEAHLDEL 43
Cdd:COG5662     1 MTCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAEL 43
zf-HC2 pfam13490
Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.
 3-36 8.50e-06

Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.


Pssm-ID: 463895 [Multi-domain]  Cd Length: 35  Bit Score: 42.15  E-value: 8.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1359351530   3 CAEFKKLWEKYENGTLTHDEQEQLESHIETCAEC 36
Cdd:pfam13490   1 CEEVRELLSAYLDGELSPEERARVEAHLAGCPAC 34
anti_SigH_actin TIGR02949
anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an ...
 2-44 5.76e-04

anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an apparent operon with a family of sigma-70 family sigma factors (TIGR02947). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria. [Transcription, Transcription factors]


Pssm-ID: 188261  Cd Length: 84  Bit Score: 38.59  E-value: 5.76e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1359351530   2 GCAE-FKKLWEkYENGTLTHDEQEQLESHIETCAEC------EAHLDELL 44
Cdd:TIGR02949   8 DCAEvIDHLYE-FLDGECTEDDAERLRRHLAACPEClreydlEQAVRKLL 56
 
Name Accession Description Interval E-value
Sigma_reg_C pfam13791
Sigma factor regulator C-terminal; This family is the C-terminal domain of a sigma factor ...
 207-365 1.86e-51

Sigma factor regulator C-terminal; This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain.


Pssm-ID: 433482  Cd Length: 157  Bit Score: 168.68  E-value: 1.86e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530 207 LAKVHDGTVAEAAISFDKAYTLKELEPLLysifeaQELPPTPVWYALDTGQERKNAEDYILHGGETIGFPEHVRFLGNET 286
Cdd:pfam13791   1 LEKLPEGTVAEVYVSFDKAYSYAEVYKML------KPEDLDLLWYAVDTGDEEKLEGDSFISETPPIGFPGNPSSSIDDF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530 287 DRQKTQEDK-----VIEMMRVLSTHKKTVSKIAALPENElNLDKRYQYVKDNGVKVYGIVITGPSKELLKLQNSPHVRYA 361
Cdd:pfam13791  75 KPKYPDELQnseehFIKLLKYLSDQEDIAKMLNADLLDG-KLDERYKYVKKNGVKIYGVVVTGPTKELLKLEKEPEVKAA 153


                  ....
gi 1359351530 362 TLGD 365
Cdd:pfam13791 154 YVGE 157
Sigma_reg_N pfam13800
Sigma factor regulator N-terminal; This domain is found near the N-terminus of a sigma factor ...
 65-153 5.41e-22

Sigma factor regulator N-terminal; This domain is found near the N-terminus of a sigma factor regulator. The N-terminus is responsible for interaction with the sigma factor.


Pssm-ID: 463986  Cd Length: 89  Bit Score: 88.84  E-value: 5.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530  65 RIKWKHRLQTFGFILSICIVIYIIGgVLSAFYFqanNDKRLEEIREVPSLALEATIPNSRVMGGGTSVEAFFRTNSSFDL 144
Cdd:pfam13800   5 KGKRKSRLRIVLISLIVFLLIFVIS-IITALYY---APKRGNELREVIELTVEITSPNVYVDSGVTSQSGFFGGEITYDL 80


                  ....*....
gi 1359351530 145 VRTVGKKEM 153
Cdd:pfam13800  81 SKRVGGKEV 89
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
1-43 8.35e-06

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 45.22  E-value: 8.35e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1359351530   1 MGCAEFKKLWEKYENGTLTHDEQEQLESHIETCAECEAHLDEL 43
Cdd:COG5662     1 MTCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAEL 43
zf-HC2 pfam13490
Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.
 3-36 8.50e-06

Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.


Pssm-ID: 463895 [Multi-domain]  Cd Length: 35  Bit Score: 42.15  E-value: 8.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1359351530   3 CAEFKKLWEKYENGTLTHDEQEQLESHIETCAEC 36
Cdd:pfam13490   1 CEEVRELLSAYLDGELSPEERARVEAHLAGCPAC 34
YlaD COG5660
Anti-sigma-YlaC factor YlaD, contains Zn-finger domain [Signal transduction mechanisms];
1-72 3.21e-04

Anti-sigma-YlaC factor YlaD, contains Zn-finger domain [Signal transduction mechanisms];


Pssm-ID: 444379 [Multi-domain]  Cd Length: 219  Bit Score: 41.68  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359351530   1 MGCAEFKKLWEKYENGTLTHDEQEQLESHIETCAECEAHLDELLT----------KSEPVKKKLPPKNLKVPFWRIKWKH 70
Cdd:COG5660     1 MDCETCREALSARLDGELEPVPAAEVDAHLAGCPACRAWLERAAAltrrlrtrpaPEVPDLTDAILAAAPPAFPRRRAYL 80


                  ..
gi 1359351530  71 RL 72
Cdd:COG5660    81 RL 82
anti_SigH_actin TIGR02949
anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an ...
 2-44 5.76e-04

anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an apparent operon with a family of sigma-70 family sigma factors (TIGR02947). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria. [Transcription, Transcription factors]


Pssm-ID: 188261  Cd Length: 84  Bit Score: 38.59  E-value: 5.76e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1359351530   2 GCAE-FKKLWEkYENGTLTHDEQEQLESHIETCAEC------EAHLDELL 44
Cdd:TIGR02949   8 DCAEvIDHLYE-FLDGECTEDDAERLRRHLAACPEClreydlEQAVRKLL 56
antisig_RsrA TIGR03988
mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, ...
 2-41 8.33e-03

mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors]


Pssm-ID: 274904  Cd Length: 77  Bit Score: 34.97  E-value: 8.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1359351530   2 GCAEF-KKLWEkYENGTLTHDEQEQLESHIETCAECEAHLD 41
Cdd:TIGR03988   1 DCSEVlAEVYE-YLDGELDDEDCARLRAHLDECPPCLEQYG 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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