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Conserved domains on  [gi|1360875869|gb|PSC73890|]
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Transcription initiation factor TFIID subunit 12 [Micractinium conductrix]

Protein Classification

transcription initiation factor TFIID subunit 12( domain architecture ID 10168398)

transcription initiation factor TFIID subunit 12 is a component of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC), and may be essential for mediating regulation of RNA polymerase transcription

CATH:  1.10.20.10
Gene Ontology:  GO:0005669|GO:0003677|GO:0042789|GO:0003713|GO:0006352|GO:0017025|GO:0046982|GO:0140297|GO:0006355
PubMed:  31751889|14969724|19308322
SCOP:  4000797

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HFD_TAF12 cd07981
histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and ...
 267-345 5.32e-22

histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and similar proteins; TAF12, also called TATA Binding Protein (TBP) associated factor 12, transcription initiation factor TFIID 20/15 kDa subunits, TAFII-20/TAFII-15, or TAFII20/TAFII15, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAFs are essential for mediating regulation of RNA polymerase transcription. TAF12 interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes. It is important for RAS-induced transformation properties of human colorectal cancer cells; its levels are increased in the cells harboring the RAS mutation. Also, TAF12 interacts with activating transcription factor 7 (ATF7) and contributes to the hypersensitivity of osteoclast (OCL) precursors to 1,25-dihydroxyvitamin D2 (1,25-(OH)2D3; also known as calcitriol) in Paget's disease (PD), a disorder of the bone remodeling process, in which the body absorbs old bone and forms abnormal new bone.


:

Pssm-ID: 467025 [Multi-domain]  Cd Length: 74  Bit Score: 89.51  E-value: 5.32e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1360875869 267 KQFAPRQRLQALVRQVGLplsltNARASEEAEGALQKVAEDFVSGAISFAVSMARRRKSEEVEPADLLLYLERTWNIQV 345
Cdd:cd07981     1 NPLLSKRKLQELVREVDP-----NERLDPDVEELLLQLADDFVDDVVTFACKLAKHRGSDTLEVKDVQLHLERNWNIRV 74
 
Name Accession Description Interval E-value
HFD_TAF12 cd07981
histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and ...
 267-345 5.32e-22

histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and similar proteins; TAF12, also called TATA Binding Protein (TBP) associated factor 12, transcription initiation factor TFIID 20/15 kDa subunits, TAFII-20/TAFII-15, or TAFII20/TAFII15, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAFs are essential for mediating regulation of RNA polymerase transcription. TAF12 interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes. It is important for RAS-induced transformation properties of human colorectal cancer cells; its levels are increased in the cells harboring the RAS mutation. Also, TAF12 interacts with activating transcription factor 7 (ATF7) and contributes to the hypersensitivity of osteoclast (OCL) precursors to 1,25-dihydroxyvitamin D2 (1,25-(OH)2D3; also known as calcitriol) in Paget's disease (PD), a disorder of the bone remodeling process, in which the body absorbs old bone and forms abnormal new bone.


Pssm-ID: 467025 [Multi-domain]  Cd Length: 74  Bit Score: 89.51  E-value: 5.32e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1360875869 267 KQFAPRQRLQALVRQVGLplsltNARASEEAEGALQKVAEDFVSGAISFAVSMARRRKSEEVEPADLLLYLERTWNIQV 345
Cdd:cd07981     1 NPLLSKRKLQELVREVDP-----NERLDPDVEELLLQLADDFVDDVVTFACKLAKHRGSDTLEVKDVQLHLERNWNIRV 74
TFIID_20kDa pfam03847
Transcription initiation factor TFIID subunit A;
272-343 7.74e-13

Transcription initiation factor TFIID subunit A;


Pssm-ID: 367691 [Multi-domain]  Cd Length: 68  Bit Score: 63.54  E-value: 7.74e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1360875869 272 RQRLQALVRQVGlplslTNARASEEAEGALQKVAEDFVSGAISFAVSMARRRKSEEVEPADLLLYLERTWNI 343
Cdd:pfam03847   2 KRKLQDLVQQID-----STTKLDEDVEDLLLEIADDFVESVTTFACKLAKHRKSDKLEVRDIQLHLERNWNM 68
COG5624 COG5624
Transcription initiation factor TFIID, subunit TAF12 [Transcription];
296-372 1.11e-07

Transcription initiation factor TFIID, subunit TAF12 [Transcription];


Pssm-ID: 227911 [Multi-domain]  Cd Length: 505  Bit Score: 54.31  E-value: 1.11e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1360875869 296 EAEGALQKVAEDFVSGAISFAVSMARRRKSEEVEPADLLLYLERTWNIQVPGFSKGDI-KPYQRRQPSADHQCRMAAV 372
Cdd:COG5624   406 EVEELLLSRADGFVEPVTEFSCRLAKHRKSDTLEVRDGQLHLERNWNIRCPGFVDDIIhMSYRKQKPTVEYCQKKLAI 483
 
Name Accession Description Interval E-value
HFD_TAF12 cd07981
histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and ...
 267-345 5.32e-22

histone-fold domain found in transcription initiation factor TFIID subunit 12 (TAF12) and similar proteins; TAF12, also called TATA Binding Protein (TBP) associated factor 12, transcription initiation factor TFIID 20/15 kDa subunits, TAFII-20/TAFII-15, or TAFII20/TAFII15, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAFs are essential for mediating regulation of RNA polymerase transcription. TAF12 interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes. It is important for RAS-induced transformation properties of human colorectal cancer cells; its levels are increased in the cells harboring the RAS mutation. Also, TAF12 interacts with activating transcription factor 7 (ATF7) and contributes to the hypersensitivity of osteoclast (OCL) precursors to 1,25-dihydroxyvitamin D2 (1,25-(OH)2D3; also known as calcitriol) in Paget's disease (PD), a disorder of the bone remodeling process, in which the body absorbs old bone and forms abnormal new bone.


Pssm-ID: 467025 [Multi-domain]  Cd Length: 74  Bit Score: 89.51  E-value: 5.32e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1360875869 267 KQFAPRQRLQALVRQVGLplsltNARASEEAEGALQKVAEDFVSGAISFAVSMARRRKSEEVEPADLLLYLERTWNIQV 345
Cdd:cd07981     1 NPLLSKRKLQELVREVDP-----NERLDPDVEELLLQLADDFVDDVVTFACKLAKHRGSDTLEVKDVQLHLERNWNIRV 74
TFIID_20kDa pfam03847
Transcription initiation factor TFIID subunit A;
272-343 7.74e-13

Transcription initiation factor TFIID subunit A;


Pssm-ID: 367691 [Multi-domain]  Cd Length: 68  Bit Score: 63.54  E-value: 7.74e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1360875869 272 RQRLQALVRQVGlplslTNARASEEAEGALQKVAEDFVSGAISFAVSMARRRKSEEVEPADLLLYLERTWNI 343
Cdd:pfam03847   2 KRKLQDLVQQID-----STTKLDEDVEDLLLEIADDFVESVTTFACKLAKHRKSDKLEVRDIQLHLERNWNM 68
COG5624 COG5624
Transcription initiation factor TFIID, subunit TAF12 [Transcription];
296-372 1.11e-07

Transcription initiation factor TFIID, subunit TAF12 [Transcription];


Pssm-ID: 227911 [Multi-domain]  Cd Length: 505  Bit Score: 54.31  E-value: 1.11e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1360875869 296 EAEGALQKVAEDFVSGAISFAVSMARRRKSEEVEPADLLLYLERTWNIQVPGFSKGDI-KPYQRRQPSADHQCRMAAV 372
Cdd:COG5624   406 EVEELLLSRADGFVEPVTEFSCRLAKHRKSDTLEVRDGQLHLERNWNIRCPGFVDDIIhMSYRKQKPTVEYCQKKLAI 483
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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