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Conserved domains on  [gi|1369174257|gb|PSL23874|]
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PD-(D/E)XK nuclease superfamily protein [Dyadobacter jiangsuensis]

Protein Classification

PD-(D/E)XK nuclease family protein( domain architecture ID 11467507)

PD-(D/E)XK nuclease family protein similar to ATP-dependent helicase/deoxyribonuclease subunit B (AddB), part of a heterodimer that acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
7-968 4.53e-53

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


:

Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 201.51  E-value: 4.53e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257    7 LVAKRILANHTSLDHVQIVVPTRRAAFFLMQELASETSEAMMSPGIMAIDDFVESICSLEIEDPVHLLFD------LYET 80
Cdd:COG3857     14 YLLEEIKEELKEGKPIILLVPEQMTFQAERALLKRLGLGGSIRAQVLSFSRLAWRVLQETGGATRPLLSDagkrmlLRKI 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257   81 FREIDPDVQ-FDRFM---GWASVLLSDLDKIDQYLVKTDFLfeylseAHALARWQESLpegkslqgeggskqyfslfENI 156
Cdd:COG3857     94 LEEHKDELKvFARAAdkpGFIEQLAELITELKRYGITPEDL------EEAAELLKEKL-------------------RDL 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  157 NKVYRSFRQRLIAKGkAYRGMAYRELAEDIGSLAEArpEGERIYFAGFNAFTTSERTIVTALIK-AKKAEVLWDSDR--- 232
Cdd:COG3857    149 ALIYEAYEEKLAGRY-IDSEDLLRLLAEKLEKSEFL--EGAEIYIDGFTDFTPQELELLEALLKkAKEVTITLTLDPdel 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  233 --YYMSENTV---VEAGKSLR---EYQRSKEFG--EWNWTGDDLLSTEKHITIYGVPNATLQTK-VAGELYQQMKrfDSD 301
Cdd:COG3857    226 dlFSATGETYerlLELAKENGvevEFKKSPELAhlERNLFAYPPEEEPEGIEIIEAANRRAEVEaVAREIRRLVR--EEG 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  302 EEPIPTAIVLADENLLLPMLYSLDQEVR-DLNVTMGLSMRNSLLYTLVDGIFELQQNvvEFRTKSgkMIR------IPKF 374
Cdd:COG3857    304 YRYRDIAVVVRDLEAYAPLIERVFAEYGiPYFIDEKRPLSHHPLVELILSLLELVRS--NFRYED--VFRllktglLRPL 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  375 GHKSIDKILNHPFIRHYEHVALTP--LEDGQTIIQRTLREITESNQVflsSEELVALGDnhPLFQILfthWQKNNAQQVI 452
Cdd:COG3857    380 SREEIDRLENYVLAYGIRGRRWLEryLEEEEELTDEEEEDLERLNEL---RDRLLEPLL--PLRERL---KKAKTVREWA 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  453 RSFYQLIELLR-----------EVYKDYKNALETE-YLYLFYTLLKQFEQTIEEraELITLRTLKSFMFELIRQTRIPFS 520
Cdd:COG3857    452 EALYEFLEELGvpekleewreaEEAGDLEEAREHEqAWNALIELLDELVEVLGD--EKLSLEEFLRILESGLEELTFGLI 529
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  521 GEPISNLQIMGMLETRALDFERIIILSVNEGTIPQAKRQNSLIPFD-----AAQAVGL-PTHQHQEAVMSYHFYRLLQRA 594
Cdd:COG3857    530 PPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPREDGLLSDEererlNELGLELpPTSRERLLEERFLFYRALTRA 609
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  595 SE-VHILYTSTNDAPGGGEKSRFVRQIEYELAEYNPKIRIENKTVVFETQQQQELEEVVH-----KDDALIAAIRAYLDG 668
Cdd:COG3857    610 SErLYLSYPLADEEGKALLPSPLIDRLRELFPELEERSLLEEELEYIGTPESALSELAAAlrqleLAPLWWDVYKWLLKL 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  669 kgiYPTHLNEFIRCSMQFYLKHIAGvkEKEEVEEELGMDKIGTWLHASLERL-------DHEFFLLDNDPSEEQIATVLR 741
Cdd:COG3857    690 ---SVSRLETYAACPFQFFLRYGLK--LKEREEYELDAPDRGTLFHAVLERFykelkeeGLDWADLSDEELEELLEEAVE 764
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  742 EEFDRLFKGYVTDLGLNRIYYQIGEQQI---LTFLRHHmAQKPRRKILAAEQP-----LHTRIQLVLQGAYTpVRVGGKI 813
Cdd:COG3857    765 ELAPELQNGILLSSARYRYLLERLKRLLkraRRWLEEE-ARRSGFEPVALELSfgpegGLPPLELELPNGRK-IRLRGRI 842
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  814 DRIELAE--GGTLYVMDYKTGSVELTgkqkladpvgREEVIRvdpdrkmGYVRQLWIYeYLMYRRMKEENGLKLRGTTYn 891
Cdd:COG3857    843 DRIDRLEsdGRYLRIIDYKSGSKKFD----------LDDVYY-------GLALQLPLY-LDAALENLEGKEAEPAGALY- 903
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  892 fgeYAVKSGFYSFRDP------KNLIANPLEITE--------------QLAPQEF---IEKSEVILTDILNVMLDPDIPF 948
Cdd:COG3857    904 ---FHLKNPKLKAKKPlkklkmKGLLLDDPEVLEiiplkkdgsfknskVLSEEEFeelLDHVRELLKEAGEEILAGDFAI 980
                         1050      1060
                   ....*....|....*....|..
gi 1369174257  949 R--KTDDLTTCQFCDFTGICGR 968
Cdd:COG3857    981 NpyRTKDRTACQYCPYKSICRF 1002
 
Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
7-968 4.53e-53

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 201.51  E-value: 4.53e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257    7 LVAKRILANHTSLDHVQIVVPTRRAAFFLMQELASETSEAMMSPGIMAIDDFVESICSLEIEDPVHLLFD------LYET 80
Cdd:COG3857     14 YLLEEIKEELKEGKPIILLVPEQMTFQAERALLKRLGLGGSIRAQVLSFSRLAWRVLQETGGATRPLLSDagkrmlLRKI 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257   81 FREIDPDVQ-FDRFM---GWASVLLSDLDKIDQYLVKTDFLfeylseAHALARWQESLpegkslqgeggskqyfslfENI 156
Cdd:COG3857     94 LEEHKDELKvFARAAdkpGFIEQLAELITELKRYGITPEDL------EEAAELLKEKL-------------------RDL 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  157 NKVYRSFRQRLIAKGkAYRGMAYRELAEDIGSLAEArpEGERIYFAGFNAFTTSERTIVTALIK-AKKAEVLWDSDR--- 232
Cdd:COG3857    149 ALIYEAYEEKLAGRY-IDSEDLLRLLAEKLEKSEFL--EGAEIYIDGFTDFTPQELELLEALLKkAKEVTITLTLDPdel 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  233 --YYMSENTV---VEAGKSLR---EYQRSKEFG--EWNWTGDDLLSTEKHITIYGVPNATLQTK-VAGELYQQMKrfDSD 301
Cdd:COG3857    226 dlFSATGETYerlLELAKENGvevEFKKSPELAhlERNLFAYPPEEEPEGIEIIEAANRRAEVEaVAREIRRLVR--EEG 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  302 EEPIPTAIVLADENLLLPMLYSLDQEVR-DLNVTMGLSMRNSLLYTLVDGIFELQQNvvEFRTKSgkMIR------IPKF 374
Cdd:COG3857    304 YRYRDIAVVVRDLEAYAPLIERVFAEYGiPYFIDEKRPLSHHPLVELILSLLELVRS--NFRYED--VFRllktglLRPL 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  375 GHKSIDKILNHPFIRHYEHVALTP--LEDGQTIIQRTLREITESNQVflsSEELVALGDnhPLFQILfthWQKNNAQQVI 452
Cdd:COG3857    380 SREEIDRLENYVLAYGIRGRRWLEryLEEEEELTDEEEEDLERLNEL---RDRLLEPLL--PLRERL---KKAKTVREWA 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  453 RSFYQLIELLR-----------EVYKDYKNALETE-YLYLFYTLLKQFEQTIEEraELITLRTLKSFMFELIRQTRIPFS 520
Cdd:COG3857    452 EALYEFLEELGvpekleewreaEEAGDLEEAREHEqAWNALIELLDELVEVLGD--EKLSLEEFLRILESGLEELTFGLI 529
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  521 GEPISNLQIMGMLETRALDFERIIILSVNEGTIPQAKRQNSLIPFD-----AAQAVGL-PTHQHQEAVMSYHFYRLLQRA 594
Cdd:COG3857    530 PPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPREDGLLSDEererlNELGLELpPTSRERLLEERFLFYRALTRA 609
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  595 SE-VHILYTSTNDAPGGGEKSRFVRQIEYELAEYNPKIRIENKTVVFETQQQQELEEVVH-----KDDALIAAIRAYLDG 668
Cdd:COG3857    610 SErLYLSYPLADEEGKALLPSPLIDRLRELFPELEERSLLEEELEYIGTPESALSELAAAlrqleLAPLWWDVYKWLLKL 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  669 kgiYPTHLNEFIRCSMQFYLKHIAGvkEKEEVEEELGMDKIGTWLHASLERL-------DHEFFLLDNDPSEEQIATVLR 741
Cdd:COG3857    690 ---SVSRLETYAACPFQFFLRYGLK--LKEREEYELDAPDRGTLFHAVLERFykelkeeGLDWADLSDEELEELLEEAVE 764
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  742 EEFDRLFKGYVTDLGLNRIYYQIGEQQI---LTFLRHHmAQKPRRKILAAEQP-----LHTRIQLVLQGAYTpVRVGGKI 813
Cdd:COG3857    765 ELAPELQNGILLSSARYRYLLERLKRLLkraRRWLEEE-ARRSGFEPVALELSfgpegGLPPLELELPNGRK-IRLRGRI 842
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  814 DRIELAE--GGTLYVMDYKTGSVELTgkqkladpvgREEVIRvdpdrkmGYVRQLWIYeYLMYRRMKEENGLKLRGTTYn 891
Cdd:COG3857    843 DRIDRLEsdGRYLRIIDYKSGSKKFD----------LDDVYY-------GLALQLPLY-LDAALENLEGKEAEPAGALY- 903
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  892 fgeYAVKSGFYSFRDP------KNLIANPLEITE--------------QLAPQEF---IEKSEVILTDILNVMLDPDIPF 948
Cdd:COG3857    904 ---FHLKNPKLKAKKPlkklkmKGLLLDDPEVLEiiplkkdgsfknskVLSEEEFeelLDHVRELLKEAGEEILAGDFAI 980
                         1050      1060
                   ....*....|....*....|..
gi 1369174257  949 R--KTDDLTTCQFCDFTGICGR 968
Cdd:COG3857    981 NpyRTKDRTACQYCPYKSICRF 1002
PDDEXK_1 pfam12705
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ...
673-966 2.02e-20

PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily


Pssm-ID: 432731 [Multi-domain]  Cd Length: 250  Bit Score: 91.83  E-value: 2.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 673 PTHLNEFIRCSMQFYLKHIAGVKEKEEVEEELgmdkIGTWLHASLERLdHEFFLLDNDPSEEQIATVLREEFDRLFKGyv 752
Cdd:pfam12705   4 PSRLETYLTCPLRFFLRYLLGLREDEELDAPD----LGTLVHAALERF-YRWGRLPEEDLEELLQALLEELWPELGLQ-- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 753 tDLGLNRIYYQIGEQqiltflrHHMAQKPRRKILAAEQPLHTRIQLVLQGAY--TPVRVGGKIDRIELAEGGTLYVMDYK 830
Cdd:pfam12705  77 -SEILPRLPWLAGRL-------RRRLERMLRRLAEWLRARRGFRPVAVELGFggTTVRLVGRIDRVDLDGEGYLRIIDYK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 831 TGSVELTgkqkladpvgreevirvDPDRKMGYVRQLWIYeYLMYRRMKEENGLklrgttynfgeyAVKSGFYSFRDPKnl 910
Cdd:pfam12705 149 TGSAPPQ-----------------SEDLDLYEGLQLLLY-LLALAAGEKALGG------------PAGALYLRLDDPL-- 196
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1369174257 911 IANPLEITEQLAPQEFIEKSEVILTDILNVMLDPDIPFRKTDDlttCQFCDFTGIC 966
Cdd:pfam12705 197 KKDEEVVEPMVLTEDEFDALLQELRELAEEILAGEFPARPGKK---CRYCPYRSIC 249
TIGR03623 TIGR03623
probable DNA repair protein; Members of this protein family are bacterial proteins of about ...
482-836 2.42e-08

probable DNA repair protein; Members of this protein family are bacterial proteins of about 900 amino acids in length. Members show extended homology to proteins in TIGR02786, the AddB protein of double-strand break repair via homologous recombination. Members of this family, therefore, may be DNA repair proteins.


Pssm-ID: 274682 [Multi-domain]  Cd Length: 874  Bit Score: 58.13  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 482 YTLLKQFEQTIEERAELITLRTLKSF--MFELIRQ--TRIPFSGE-PISNLQIMGMLETRALDFERIIILSVNEGTIPQA 556
Cdd:TIGR03623 409 YQAVKAWEELLAEFAALDLVSPALTFseALRLLRQlaAETLFQPEtPEAPIQVLGLLEAAGLQFDALWVMGLTDEQWPAP 488
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 557 KRQNSLIPFDAAQAVGLPtHQHQEAVMSYH---FYRLLQRASEVHILYTSTNdapGGGEK--SRFVRQIE------YELA 625
Cdd:TIGR03623 489 PRPNPFLPLALQRAVGMP-HASAERELDYArqvTQRLLKSAPEVVFSYPRRD---GDRELrpSPLIAHLPlkaeedAELA 564
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 626 EYNPKIrienktvvfetqqqqeleevvhkddALIAAIR---AYLDGKGIyPTHLNEFIR-----------CSMQFYLKHI 691
Cdd:TIGR03623 565 DYQDLA-------------------------AAVAAGSrleVLDDAQAP-PLAAGERISggtgllkaqaaCPFRAFAQHR 618
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 692 AGVKEKEEVEeeLGMDKI--GTWLHASLE----RLDHEFFLLDNDPSE------EQIATVLREEFDR---LFKGYVTDLG 756
Cdd:TIGR03623 619 LGARALEEPV--DGLDALerGTLVHRVLElfweRLKNQEALNALDEAEleqliaEAIEEALAEERARhsqTFPERFLELE 696
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 757 LNRIyyqigEQQILTFLRHHMaQKPRRKILAAEQPLHTRIQlvlqgaytPVRVGGKIDRI-ELAEGGTLyVMDYKTGSVE 835
Cdd:TIGR03623 697 QERL-----LQLLLEWLELER-KRPPFEVVATEQNHSIEIG--------GLELKLRIDRIdRLADGSRL-IIDYKTGAPS 761

                  .
gi 1369174257 836 L 836
Cdd:TIGR03623 762 V 762
 
Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
7-968 4.53e-53

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 201.51  E-value: 4.53e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257    7 LVAKRILANHTSLDHVQIVVPTRRAAFFLMQELASETSEAMMSPGIMAIDDFVESICSLEIEDPVHLLFD------LYET 80
Cdd:COG3857     14 YLLEEIKEELKEGKPIILLVPEQMTFQAERALLKRLGLGGSIRAQVLSFSRLAWRVLQETGGATRPLLSDagkrmlLRKI 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257   81 FREIDPDVQ-FDRFM---GWASVLLSDLDKIDQYLVKTDFLfeylseAHALARWQESLpegkslqgeggskqyfslfENI 156
Cdd:COG3857     94 LEEHKDELKvFARAAdkpGFIEQLAELITELKRYGITPEDL------EEAAELLKEKL-------------------RDL 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  157 NKVYRSFRQRLIAKGkAYRGMAYRELAEDIGSLAEArpEGERIYFAGFNAFTTSERTIVTALIK-AKKAEVLWDSDR--- 232
Cdd:COG3857    149 ALIYEAYEEKLAGRY-IDSEDLLRLLAEKLEKSEFL--EGAEIYIDGFTDFTPQELELLEALLKkAKEVTITLTLDPdel 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  233 --YYMSENTV---VEAGKSLR---EYQRSKEFG--EWNWTGDDLLSTEKHITIYGVPNATLQTK-VAGELYQQMKrfDSD 301
Cdd:COG3857    226 dlFSATGETYerlLELAKENGvevEFKKSPELAhlERNLFAYPPEEEPEGIEIIEAANRRAEVEaVAREIRRLVR--EEG 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  302 EEPIPTAIVLADENLLLPMLYSLDQEVR-DLNVTMGLSMRNSLLYTLVDGIFELQQNvvEFRTKSgkMIR------IPKF 374
Cdd:COG3857    304 YRYRDIAVVVRDLEAYAPLIERVFAEYGiPYFIDEKRPLSHHPLVELILSLLELVRS--NFRYED--VFRllktglLRPL 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  375 GHKSIDKILNHPFIRHYEHVALTP--LEDGQTIIQRTLREITESNQVflsSEELVALGDnhPLFQILfthWQKNNAQQVI 452
Cdd:COG3857    380 SREEIDRLENYVLAYGIRGRRWLEryLEEEEELTDEEEEDLERLNEL---RDRLLEPLL--PLRERL---KKAKTVREWA 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  453 RSFYQLIELLR-----------EVYKDYKNALETE-YLYLFYTLLKQFEQTIEEraELITLRTLKSFMFELIRQTRIPFS 520
Cdd:COG3857    452 EALYEFLEELGvpekleewreaEEAGDLEEAREHEqAWNALIELLDELVEVLGD--EKLSLEEFLRILESGLEELTFGLI 529
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  521 GEPISNLQIMGMLETRALDFERIIILSVNEGTIPQAKRQNSLIPFD-----AAQAVGL-PTHQHQEAVMSYHFYRLLQRA 594
Cdd:COG3857    530 PPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPREDGLLSDEererlNELGLELpPTSRERLLEERFLFYRALTRA 609
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  595 SE-VHILYTSTNDAPGGGEKSRFVRQIEYELAEYNPKIRIENKTVVFETQQQQELEEVVH-----KDDALIAAIRAYLDG 668
Cdd:COG3857    610 SErLYLSYPLADEEGKALLPSPLIDRLRELFPELEERSLLEEELEYIGTPESALSELAAAlrqleLAPLWWDVYKWLLKL 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  669 kgiYPTHLNEFIRCSMQFYLKHIAGvkEKEEVEEELGMDKIGTWLHASLERL-------DHEFFLLDNDPSEEQIATVLR 741
Cdd:COG3857    690 ---SVSRLETYAACPFQFFLRYGLK--LKEREEYELDAPDRGTLFHAVLERFykelkeeGLDWADLSDEELEELLEEAVE 764
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  742 EEFDRLFKGYVTDLGLNRIYYQIGEQQI---LTFLRHHmAQKPRRKILAAEQP-----LHTRIQLVLQGAYTpVRVGGKI 813
Cdd:COG3857    765 ELAPELQNGILLSSARYRYLLERLKRLLkraRRWLEEE-ARRSGFEPVALELSfgpegGLPPLELELPNGRK-IRLRGRI 842
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  814 DRIELAE--GGTLYVMDYKTGSVELTgkqkladpvgREEVIRvdpdrkmGYVRQLWIYeYLMYRRMKEENGLKLRGTTYn 891
Cdd:COG3857    843 DRIDRLEsdGRYLRIIDYKSGSKKFD----------LDDVYY-------GLALQLPLY-LDAALENLEGKEAEPAGALY- 903
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  892 fgeYAVKSGFYSFRDP------KNLIANPLEITE--------------QLAPQEF---IEKSEVILTDILNVMLDPDIPF 948
Cdd:COG3857    904 ---FHLKNPKLKAKKPlkklkmKGLLLDDPEVLEiiplkkdgsfknskVLSEEEFeelLDHVRELLKEAGEEILAGDFAI 980
                         1050      1060
                   ....*....|....*....|..
gi 1369174257  949 R--KTDDLTTCQFCDFTGICGR 968
Cdd:COG3857    981 NpyRTKDRTACQYCPYKSICRF 1002
COG3893 COG3893
Inactivated superfamily I helicase [Replication, recombination and repair];
1-850 4.14e-50

Inactivated superfamily I helicase [Replication, recombination and repair];


Pssm-ID: 443100 [Multi-domain]  Cd Length: 965  Bit Score: 191.93  E-value: 4.14e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257   1 MPSFLNLVAKRILANH----TSLDHVQIVVPTRRAAFFLMQELASETSEAMMSPGIMAIDDFVESICSLEI---EDPVHL 73
Cdd:COG3893     9 GAPFLDALAAGLLARLagdpLALARVTILLPTRRAARALREAFLRLLGRALLLPRIRPLGDLDEDELLLDLppaISPLER 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  74 LFDLYETFREIDPDVQ---FDRFMGWASVLLSDLDKIDQYLVKTDFLFEYLSEAHAlARWQESLpegkslqgeggskqyf 150
Cdd:COG3893    89 RLLLARLVRRWADALVpasPADALDLADSLARLMDELETEGVDLEALADLVPDDLA-GHWQRTL---------------- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 151 slfENINKVYRSFRQRLIAKGKAYRGMAYRELAEDIGSLAEARPEGeRIYFAGFNAFTTSERTIVTALIKAKKAEVLWD- 229
Cdd:COG3893   152 ---DFLKIVTEAWPAILAERGLIDPAARRRALLEALAARWRAAPAG-PVIAAGSTGSTPATARLLAAVARLPQGAVVLPg 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 230 -------------------------SDRYYMSENTVVEAGKSLREYQRSKEFGE----------WNWTGDDLLsteKHIT 274
Cdd:COG3893   228 ldldldeaawaalaedhpqyglkrlLDRLGVTREDVRPWGATPALPARARLLSEalrpaettdaWRDLGAAAL---AGLT 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 275 IYGVPNATLQTKVAGE-LYQQMkrfdsdEEPI-PTAIVLADENLLLPMLYSLDQEVRDLNVTMGLSMRNSLLYTLVDGIF 352
Cdd:COG3893   305 LIEAADPEEEALAIALaLREAL------EEPGrTAALVTPDRALARRVAAELERWGIEVDDSAGWPLSTTPAGALLRLLL 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 353 ELQQNvvefrtksgkmiripKFGHKSIDKILNHPFIR-------HYEHVALtpLEDG---QTIIQRTLREITESNQVFL- 421
Cdd:COG3893   379 ELAAE---------------PLAPVALLALLKHPLVRlglgrgdHRRAVRA--LELAlrrGGRPAPGLAGLRAALARARp 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 422 -SSEELVALGDN-----HPLFQILftHWQKNNAQQVIRSFYQLIELLREVYKDYKNALET-EYLYLFYTLLKQFEQTIEE 494
Cdd:COG3893   442 dDAEAAAALLDRleaalAPLLALF--AAGKRPLADWLAALRALLEALGADEEGGEDALWAgEAGEALLELLAELAAAAGA 519
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 495 RAELiTLRTLKSFMFELIRQTRIPFSGEPISNLQIMGMLETRALDFERIIILSVNEGTIPQAKRQNSLIPFDAAQAVGLP 574
Cdd:COG3893   520 GGPL-SAAEYPALLRALLEGTTVRPPGGPHPRVQILGLLEARLQRFDAVILGGLNEGVWPPAPRPDPWLSRPMRRALGLP 598
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 575 THQHQEAVMSYHFYRLLqRASEVHILY-TSTNDAPggGEKSRFVRQIEYELAEYNPKIRIENKTVVFETQQQQELEEVVH 653
Cdd:COG3893   599 TPERRIGLAAHDFAQAL-GAPEVVLSRaRRSDGAP--TVPSRWLQRLEALLGGAALAAMGARWLAWARALDRPAPVAPAA 675
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 654 KDDALIAAIRAyldgkgiyPTHLNEFIRCSMQFYLKHIAGVKEKEEVEEELGMDKIGTWLHASLERLDHEFFLLDNDPSE 733
Cdd:COG3893   676 RPAPKPPVARR--------PRLSSVTIETLLRDPPYAYYARRLLLLLLLPPLADPPAAARGGLLHHALLEFFEREPPALP 747
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 734 EQIATVLREEFDRLFKGYVTDLGLNRIYYQIGEQQILTFLRhhMAQKPRRKILAAEQPLHTRIQLVLQGAYTPVRVggkI 813
Cdd:COG3893   748 ADAAAALLLALAEALLALAAAPAAAAAWWARRLRRAAAFAA--AEEERRRALAREEAEEEGGRLALLEGGLLLLLR---R 822
                         890       900       910
                  ....*....|....*....|....*....|....*..
gi 1369174257 814 DRIELAEGGTLYVMDYKTGSVELTGKQKLADPVGREE 850
Cdd:COG3893   823 RDRDDDDGDGDGGDDDKTTTTGPPAKKLLLDLQLLLL 859
Slr0479 COG2887
RecB family exonuclease [Replication, recombination and repair];
673-966 1.56e-28

RecB family exonuclease [Replication, recombination and repair];


Pssm-ID: 442133 [Multi-domain]  Cd Length: 248  Bit Score: 115.13  E-value: 1.56e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 673 PTHLNEFIRCSMQFYLKHIAGVKEKEEVEeeLGMDKIGTWLHASLERLdheFFLLDNDPSEEQIATVLREEFDRLFKGyv 752
Cdd:COG2887     5 PSRIETLLRCPLRYYARYILGLRDPLEPP--PDAADRGTLVHAVLERF---YKLPADELPAEELLALLEEAWAELGFE-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 753 tDLGLNRIYYQIGEQQILTFLRHHmAQKPRRKILAAEQPLHTRIQLvlqgaytPVRVGGKIDRIELAEGGTLYVMDYKTG 832
Cdd:COG2887    78 -DPWAAALWLERAERLLEAFLEWE-RAPAGLEPVAVEVEFELELPG-------GVRLRGRIDRIDRLPDGRLVVVDYKTG 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 833 SVELTGKQKLADPvgreevirvdpdrkmgyvrQLWIYEYLMYRRMKeenglklrgttynfGEYAVKSGFYSFRDPKNLIa 912
Cdd:COG2887   149 KAPSTKDEAGEDP-------------------QLALYALALERGFE--------------GLVPAGARLVYLGDLGKKK- 194
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1369174257 913 nPLEITEqlapqEFIEKSEVILTDILNVMLDPDIPFRKTDDLTTCQFCDFTGIC 966
Cdd:COG2887   195 -VLDPLE-----EELEEAEERLEELAAAIADPEGPFPARPNPPLCRYCDYRHLC 242
PDDEXK_1 pfam12705
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ...
673-966 2.02e-20

PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily


Pssm-ID: 432731 [Multi-domain]  Cd Length: 250  Bit Score: 91.83  E-value: 2.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 673 PTHLNEFIRCSMQFYLKHIAGVKEKEEVEEELgmdkIGTWLHASLERLdHEFFLLDNDPSEEQIATVLREEFDRLFKGyv 752
Cdd:pfam12705   4 PSRLETYLTCPLRFFLRYLLGLREDEELDAPD----LGTLVHAALERF-YRWGRLPEEDLEELLQALLEELWPELGLQ-- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 753 tDLGLNRIYYQIGEQqiltflrHHMAQKPRRKILAAEQPLHTRIQLVLQGAY--TPVRVGGKIDRIELAEGGTLYVMDYK 830
Cdd:pfam12705  77 -SEILPRLPWLAGRL-------RRRLERMLRRLAEWLRARRGFRPVAVELGFggTTVRLVGRIDRVDLDGEGYLRIIDYK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 831 TGSVELTgkqkladpvgreevirvDPDRKMGYVRQLWIYeYLMYRRMKEENGLklrgttynfgeyAVKSGFYSFRDPKnl 910
Cdd:pfam12705 149 TGSAPPQ-----------------SEDLDLYEGLQLLLY-LLALAAGEKALGG------------PAGALYLRLDDPL-- 196
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1369174257 911 IANPLEITEQLAPQEFIEKSEVILTDILNVMLDPDIPFRKTDDlttCQFCDFTGIC 966
Cdd:pfam12705 197 KKDEEVVEPMVLTEDEFDALLQELRELAEEILAGEFPARPGKK---CRYCPYRSIC 249
TIGR03623 TIGR03623
probable DNA repair protein; Members of this protein family are bacterial proteins of about ...
482-836 2.42e-08

probable DNA repair protein; Members of this protein family are bacterial proteins of about 900 amino acids in length. Members show extended homology to proteins in TIGR02786, the AddB protein of double-strand break repair via homologous recombination. Members of this family, therefore, may be DNA repair proteins.


Pssm-ID: 274682 [Multi-domain]  Cd Length: 874  Bit Score: 58.13  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 482 YTLLKQFEQTIEERAELITLRTLKSF--MFELIRQ--TRIPFSGE-PISNLQIMGMLETRALDFERIIILSVNEGTIPQA 556
Cdd:TIGR03623 409 YQAVKAWEELLAEFAALDLVSPALTFseALRLLRQlaAETLFQPEtPEAPIQVLGLLEAAGLQFDALWVMGLTDEQWPAP 488
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 557 KRQNSLIPFDAAQAVGLPtHQHQEAVMSYH---FYRLLQRASEVHILYTSTNdapGGGEK--SRFVRQIE------YELA 625
Cdd:TIGR03623 489 PRPNPFLPLALQRAVGMP-HASAERELDYArqvTQRLLKSAPEVVFSYPRRD---GDRELrpSPLIAHLPlkaeedAELA 564
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 626 EYNPKIrienktvvfetqqqqeleevvhkddALIAAIR---AYLDGKGIyPTHLNEFIR-----------CSMQFYLKHI 691
Cdd:TIGR03623 565 DYQDLA-------------------------AAVAAGSrleVLDDAQAP-PLAAGERISggtgllkaqaaCPFRAFAQHR 618
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 692 AGVKEKEEVEeeLGMDKI--GTWLHASLE----RLDHEFFLLDNDPSE------EQIATVLREEFDR---LFKGYVTDLG 756
Cdd:TIGR03623 619 LGARALEEPV--DGLDALerGTLVHRVLElfweRLKNQEALNALDEAEleqliaEAIEEALAEERARhsqTFPERFLELE 696
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257 757 LNRIyyqigEQQILTFLRHHMaQKPRRKILAAEQPLHTRIQlvlqgaytPVRVGGKIDRI-ELAEGGTLyVMDYKTGSVE 835
Cdd:TIGR03623 697 QERL-----LQLLLEWLELER-KRPPFEVVATEQNHSIEIG--------GLELKLRIDRIdRLADGSRL-IIDYKTGAPS 761

                  .
gi 1369174257 836 L 836
Cdd:TIGR03623 762 V 762
addB_alphas TIGR02786
double-strand break repair protein AddB, alphaproteobacterial type; AddAB is a system well ...
526-840 3.56e-08

double-strand break repair protein AddB, alphaproteobacterial type; AddAB is a system well described in the Firmicutes as a replacement for RecBCD in many prokaryotes for the repair of double stranded break DNA damage. More recently, a distantly related gene pair conserved in many alphaproteobacteria was shown also to function in double-stranded break repair in Rhizobium etli. This family consists of AddB proteins of the alphaproteobacteial type. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274300 [Multi-domain]  Cd Length: 1021  Bit Score: 57.83  E-value: 3.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  526 NLQIMGMLETRALDFERIIILSVNEGTIPQAKRQNSLIPFDAAQAVGLPTHQHQEAVMSYHFYRLLqraSEVHILYTST- 604
Cdd:TIGR02786  606 RIFIWGALEARLQTADLVVIGGLNEGVWPPAPRNDPFLSRPMRHELGLPPPERRIGLSAHDFQQAL---GAKEVVLTRAa 682
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  605 --NDAPGggEKSRFVRQIEYELAEynpkirienktvVFETQQQQELEEVVHKDDALIAAIRA------------YLDGKG 670
Cdd:TIGR02786  683 rsGGAPA--VPSRWLQRLEALAGA------------DVLEEMRRRGERYLHWARALDEPQDVapatrpaprppvADRPRH 748
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  671 IYPTHLNEFIRCSMQFYLKHIAGVKEKEEVEEELGMDKIGTWLHASLERldheFFLLDNDPSEEQIATVLREEFDRLFKG 750
Cdd:TIGR02786  749 FSVTEIETLRRDPYAIYARHILKLRPLDPLDRDPEAADRGTLIHDILER----FVREYPDPLPADAADALRKIGRAEFAS 824
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1369174257  751 YVTDLGLNRIYYQIGEQQILTFLRHHMAQKPRRKILAAEQplHTRIQLVLQgayTPVRVGGKIDRIELAEGGTLYVMDYK 830
Cdd:TIGR02786  825 LNLPPTAEALWWPRFARAADWFADWERARRLDVRRIFAEA--RGRKELVGE---RGFTLSGRADRIDRTPDGSAAILDYK 899
                          330
                   ....*....|
gi 1369174257  831 TGSVElTGKQ 840
Cdd:TIGR02786  900 TGAPP-SGKQ 908
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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