|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
118-448 |
1.82e-74 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 238.68 E-value: 1.82e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 118 FAMVSLPIVWKNGEVVNLQLYENVDFKYETFQILKWILIGSTLFILVLIFYINNVMTRIITSPILKLIQHIKETKETKDY 197
Cdd:COG5002 52 LALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 198 RPVLVHKNDSYELKVLSTAFNEMMTKLGEHDEKQRAFIMNASHELKTPITVISSYSQMLKRFGKKDAKTLDESIHAIHDE 277
Cdd:COG5002 132 GRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 278 AQKMKYLTEQLLYFAQITENKTERRLEKVNVADIVNELVKRMANVYPQ---TLKFYNQTHSSEVCLDVPSFKQLLHIFMD 354
Cdd:COG5002 212 AERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEkgiELELDLPEDPLLVLGDPDRLEQVLTNLLD 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYGR--TCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQV 432
Cdd:COG5002 292 NAIKYTPegGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWV 371
|
330
....*....|....*.
gi 1374812345 433 KSQVNVGTTFTLIIPK 448
Cdd:COG5002 372 ESEPGKGTTFTITLPL 387
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
216-451 |
4.60e-63 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 203.99 E-value: 4.60e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 216 AFNEMMTKLGEHDEKQRAFIMNASHELKTPITVISSYSQMLKRFGKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQIT 295
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 296 ENKTERRLEKVNVADIVNELVKRMANVYPQ---TLKFYNQTHSSEVCLDVPSFKQLLHIFMDNAHKYGR--TCIALTLTE 370
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEkgiRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPpgGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 371 TKSNLVLSIADDGIGIPEEELPHIFTRFYRVDkaRSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGG 450
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
.
gi 1374812345 451 P 451
Cdd:COG2205 239 S 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
223-449 |
3.35e-59 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 197.05 E-value: 3.35e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 223 KLGEHDEKQRAFIMNASHELKTPITVISSYSQMLKRfgkKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITENKTERR 302
Cdd:COG0642 102 LLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLE---ELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELE 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 303 LEKVNVADIVNELVKRMANVYPQ---TLKFYNQTHSSEVCLDVPSFKQLLHIFMDNAHKYGR--TCIALTLTETKSNLVL 377
Cdd:COG0642 179 PEPVDLAELLEEVVELFRPLAEEkgiELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPegGTVTVSVRREGDRVRI 258
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1374812345 378 SIADDGIGIPEEELPHIFTRFYRVDkaRSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKG 449
Cdd:COG0642 259 SVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
239-453 |
8.91e-35 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 134.32 E-value: 8.91e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 239 SHELKTPITVISSYSQMLKR-FGKK---DAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITENKterrLEKVNVADIVNE 314
Cdd:COG5000 209 AHEIKNPLTPIQLSAERLRRkLADKleeDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQ----LEPVDLNELLRE 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 315 LVKRMANVYPQ---TLKFYNQTHSSEVCLDVPSFKQLLHIFMDNAH----KYGRtcIALTLTETKSNLVLSIADDGIGIP 387
Cdd:COG5000 285 VLALYEPALKEkdiRLELDLDPDLPEVLADRDQLEQVLINLLKNAIeaieEGGE--IEVSTRREDGRVRIEVSDNGPGIP 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 388 EEELPHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGGPHE 453
Cdd:COG5000 363 EEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
238-448 |
8.19e-33 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 129.91 E-value: 8.19e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 238 ASHELKTPITVISSYSQMLK-RFGKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITenKTERRLEKVNVADIVNELV 316
Cdd:COG4251 289 ASHDLREPLRKISGFSQLLEeDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVG--RQELEFEPVDLNELLEEVL 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 317 KRMANVYPQT-LKFynqTHSS--EVCLDVPSFKQLLHIFMDNAHKYGRTC----IALTLTETKSNLVLSIADDGIGIPEE 389
Cdd:COG4251 367 EDLEPRIEERgAEI---EVGPlpTVRGDPTLLRQVFQNLISNAIKYSRPGepprIEIGAEREGGEWVFSVRDNGIGIDPE 443
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1374812345 390 ELPHIFTRFYRVDkaRSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPK 448
Cdd:COG4251 444 YAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
149-447 |
1.97e-31 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 125.58 E-value: 1.97e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 149 QILKWiLIGSTLFILVLIFYINNVMTRIITSPILKLIQHIKE-TKETKDYRpvLVHKNDSYELKVLSTAFNEMMTKLGEH 227
Cdd:TIGR01386 161 ALRKW-LILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARiSPESLDQR--LDPSRAPAELRELAQSFNAMLGRLEDA 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 228 DEKQRAFIMNASHELKTPITVISSYSQM-LKRfgKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITENKTERRLEKV 306
Cdd:TIGR01386 238 FQRLSQFSADLAHELRTPLTNLLGQTQVaLSQ--PRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRL 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 307 NVADIVNELVKRMANVYPQTLKFYNQTHSSEVCLDVPSFKQLLHIFMDNAHKYG--RTCIALTLTETKSNLVLSIADDGI 384
Cdd:TIGR01386 316 DLAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSDEVRVSVSNPGP 395
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1374812345 385 GIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQVKSQVnVGTTFTLIIP 447
Cdd:TIGR01386 396 GIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPD-GKTRFILRFP 457
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
240-447 |
2.79e-31 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 123.37 E-value: 2.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 240 HELKTPITVISSYSQMLKRF--GKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQitenKTERRLEKVNVADIVNELVK 317
Cdd:COG4191 151 HEINNPLAAILGNAELLRRRleDEPDPEELREALERILEGAERAAEIVRSLRAFSR----RDEEEREPVDLNELIDEALE 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 318 RMANVYPQ---TLKFYNQTHSSEVCLDVPSFKQLLHIFMDNA-----HKYGRTcIALTLTETKSNLVLSIADDGIGIPEE 389
Cdd:COG4191 227 LLRPRLKArgiEVELDLPPDLPPVLGDPGQLEQVLLNLLINAidameEGEGGR-ITISTRREGDYVVISVRDNGPGIPPE 305
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1374812345 390 ELPHIFTRFY---RVDKarsrktgGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:COG4191 306 VLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
345-446 |
7.00e-31 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 114.62 E-value: 7.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 345 FKQLLHIFMDNAHKYG--RTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKarSRKTGGSGLGLSIAREI 422
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1374812345 423 SQQQHIDIQVKSQVNVGTTFTLII 446
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
341-448 |
2.67e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 113.51 E-value: 2.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 341 DVPSFKQLLHIFMDNAHKYGRTC--IALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKaRSRKTGGSGLGLSI 418
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGgrITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|
gi 1374812345 419 AREISQQQHIDIQVKSQVNVGTTFTLIIPK 448
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
240-454 |
6.26e-30 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 119.57 E-value: 6.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 240 HELKTPITVISSYSQMLKRfgKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQitenKTERRLEKVNVADIVNELVKRM 319
Cdd:COG3852 144 HEIRNPLTGIRGAAQLLER--ELPDDELREYTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVLELL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 320 ANVYPQTLKFYNQTHSS--EVCLDVPSFKQ-LLHIFMdNA----HKYG----RTCIALTLTETKSN----LVLSIADDGI 384
Cdd:COG3852 218 RAEAPKNIRIVRDYDPSlpEVLGDPDQLIQvLLNLVR-NAaeamPEGGtitiRTRVERQVTLGGLRprlyVRIEVIDNGP 296
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 385 GIPEEELPHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGGPHET 454
Cdd:COG3852 297 GIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEE 360
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
232-449 |
3.27e-29 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 118.57 E-value: 3.27e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 232 RAFIMNASHELKTPITVISSYSQMLKRfGKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITENKTERRLEKVNVADI 311
Cdd:PRK11006 205 RNFFANVSHELRTPLTVLQGYLEMMQD-QPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMM 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 312 VnELVKRMAnvypQTLKFYNQTHSSEV--CLDVPSFKQLLHIFMDN------AHKYGRTCIALTLTETKSNLVLSIADDG 383
Cdd:PRK11006 284 L-RVLEREA----QTLSQGKHTITFEVdnSLKVFGNEDQLRSAISNlvynavNHTPEGTHITVRWQRVPQGAEFSVEDNG 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 384 IGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKG 449
Cdd:PRK11006 359 PGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPER 424
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
141-450 |
5.15e-27 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 112.94 E-value: 5.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 141 VDFKYETFQILKWILIGSTLFILVLIFYINNVMTRIITSPILKLIQHIKE-TKETKDYR--PVLVhkndSYELKVLSTAF 217
Cdd:PRK09835 173 IDFHLHYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNiTSKDLDVRldPQTV----PIELEQLVLSF 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 218 NEMMTKLGEHDEKQRAFIMNASHELKTPITVISSYSQM-LKRfgKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITE 296
Cdd:PRK09835 249 NHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIaLSQ--SRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADN 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 297 NKTerRLEKVNVaDIVNELVK------RMANVYPQTLKFYNQTHSseVCLDVPSFKQLLHIFMDNAHKY---GRTcIALT 367
Cdd:PRK09835 327 NQL--IPEKKML-DLADEVGKvfdffeAWAEERGVELRFVGDPCQ--VAGDPLMLRRAISNLLSNALRYtpaGEA-ITVR 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 368 LTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQVKSQVnVGTTFTLIIP 447
Cdd:PRK09835 401 CQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
...
gi 1374812345 448 KGG 450
Cdd:PRK09835 480 RLE 482
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
341-447 |
8.94e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 103.60 E-value: 8.94e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 341 DVPSFKQLLHIFMDNAHKYGRTCIALTLT-ETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKarsRKTGGSGLGLSIA 419
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*...
gi 1374812345 420 REISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
345-447 |
1.22e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 97.95 E-value: 1.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 345 FKQLLHIFMDNAHKY---GR---TCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSI 418
Cdd:cd16922 1 LRQILLNLLGNAIKFteeGEvtlRVSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1374812345 419 AREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
355-448 |
1.77e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 97.01 E-value: 1.77e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQVKS 434
Cdd:cd16949 11 NALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGGKIKASN 90
|
90
....*....|....
gi 1374812345 435 QVNVGTTFTLIIPK 448
Cdd:cd16949 91 RKPGGLRVRIWLPA 104
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
240-447 |
2.26e-23 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 103.12 E-value: 2.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 240 HELKTPITVISSYSQMLKRFGKKDAKTldESIHAIHDEAQKMKYLTEQLLYFAQITENKterrLEKVNVadivNELVKRM 319
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPSQ--EYLSVVLREVDRLNKVIDQLLEFSRPRESQ----WQPVSL----NALVEEV 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 320 ANVYPQTLKFYNQTHSSEVCLDVP-------SFKQLLHIFMDNAHKYGRTCIALTLT---ETKSNLVLSIADDGIGIPEE 389
Cdd:PRK11360 469 LQLFQTAGVQARVDFETELDNELPpiwadpeLLKQVLLNILINAVQAISARGKIRIRtwqYSDGQVAVSIEDNGCGIDPE 548
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1374812345 390 ELPHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:PRK11360 549 LLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
213-447 |
3.07e-23 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 101.60 E-value: 3.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 213 LSTAFNEMMTKLGEHDEKQRAFIMNASHELKTPITVISSYSQMLkrfgkkDAKTLDESiHAIHDEAQKMKYLTEQLLYFA 292
Cdd:PRK10604 194 LGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMS------DNLSAAES-QALNRDIGQLEALIEELLTYA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 293 QITENKTERRLEKVNVADIVNELVKRMANVYPQ-TLKFYNQTHSSEVCLDVPSFKQLLHIFMDNAHKYGRTCIALTLTET 371
Cdd:PRK10604 267 RLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEkTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLD 346
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 372 KSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:PRK10604 347 GNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
208-427 |
1.12e-22 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 100.01 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 208 YELKVLSTAFNEMMTKLGEHDEKQRAFIMNASHELKTPITVISSYSQMLKRfgkkdakTLDES--IHAIHDEAQKMKYLT 285
Cdd:PRK09470 220 QEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRR-------RQGESkeLERIETEAQRLDSMI 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 286 EQLLYFAQITENKTERRlEKVNVADIVNELVKRManvypqtlKF-YNQTHSSevcLDVPSFKQLLHIFMD---------- 354
Cdd:PRK09470 293 NDLLVLSRNQQKNHLER-ETFKANSLWSEVLEDA--------KFeAEQMGKS---LTVSAPPGPWPINGNpnalasalen 360
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 355 ---NAHKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQH 427
Cdd:PRK09470 361 ivrNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHR 436
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
150-450 |
1.44e-20 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 93.76 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 150 ILKW--ILIGSTLFILVLifyinnvMTRIITSPILKLIQHIKETKETkdyRPVLVHKNDSYELKVLSTAFNEMMTKLGEH 227
Cdd:PRK11100 184 ILWAgaLLLGIALLIGAG-------VVWWLNRSIRRLTRYADAVTEG---KPVPLPKLGSSELRELAQALESMRVKLEGK 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 228 DEKQRaFIMNASHELKTPITVISSYSQMLKrfGKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQItENKTER-RLEKV 306
Cdd:PRK11100 254 AYVEQ-YVQTLTHELKSPLAAIRGAAELLQ--EDPPPEDRARFTGNILTQSARLQQLIDRLLELARL-EQRQELeVLEPV 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 307 NVADIVNELVKRMANVYPQ-TLKFYNQTHSSEVCLDVPSFKQLLHIFMDNA----HKYGrtCIALTLTETKSNLVLSIAD 381
Cdd:PRK11100 330 ALAALLEELVEAREAQAAAkGITLRLRPDDARVLGDPFLLRQALGNLLDNAidfsPEGG--TITLSAEVDGEQVALSVED 407
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1374812345 382 DGIGIPEEELPHIFTRFY---RVDKARSrktgGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGG 450
Cdd:PRK11100 408 QGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
355-447 |
3.55e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 82.64 E-value: 3.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYGR--TCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQV 432
Cdd:cd16952 11 NAVKYTPpsDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDARLLI 90
|
90
....*....|....*
gi 1374812345 433 KSQVNVGTTFTLIIP 447
Cdd:cd16952 91 ASELGKGSRFTCLFP 105
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
207-427 |
3.75e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 89.20 E-value: 3.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 207 SYELKVLSTAFNEM---MTKLgehdEKQRAFIM-NASHELKTPITVISSYSQMLkrfGKKDAkTLDESIhaIHDeAQKMK 282
Cdd:PRK09467 205 ASEVRSVTRAFNQMaagIKQL----EDDRTLLMaGVSHDLRTPLTRIRLATEMM---SEEDG-YLAESI--NKD-IEECN 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 283 YLTEQLL-YFAQITENKTERrlekVNVADIVNELVKRMANvYPQTLKFYNQTHSSEVCLDVPSFKQLLHIFMDNAHKYGR 361
Cdd:PRK09467 274 AIIEQFIdYLRTGQEMPMEM----ADLNALLGEVIAAESG-YEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGN 348
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 362 TCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSrkTGGSGLGLSIAREISQQQH 427
Cdd:PRK09467 349 GWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHN 412
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
177-427 |
4.32e-19 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 88.10 E-value: 4.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 177 ITSPILKLiQHIKETKETKDYRPVLVHkNDSYELKVLSTAFNEMMTKLGEHDEKQRAFIMNASHELKTPITVISSYSQML 256
Cdd:PRK10755 85 ITRPLAEL-QKELEARTADNLTPIAIH-SSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 257 KRFGKKDAKTL----DESIHAIhdeaqkmkyltEQLLYFAQITENKTERRLEKVN-VADIV----NELvKRMANVYPQTL 327
Cdd:PRK10755 163 EKQHHIDVAPLiarlDQMMHTV-----------EQLLQLARAGQSFSSGHYQTVKlLEDVIlpsqDEL-SEMLEQRQQTL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 328 KFYNQTHSSEVCLDVPSFKQLLHIFMDNAHKYG--RTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDkar 405
Cdd:PRK10755 231 LLPESAADITVQGDATLLRLLLRNLVENAHRYSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD--- 307
|
250 260
....*....|....*....|..
gi 1374812345 406 sRKTGGSGLGLSIAREISQQQH 427
Cdd:PRK10755 308 -SRYGGIGLGLSIVSRITQLHH 328
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
239-447 |
4.72e-18 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 85.22 E-value: 4.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 239 SHELKTPITVISSYSQMLKRFGKKDAKtlDESIHAIHDEAQKMKYLTEQLLYFAqiteNKTERRLEKVNVADIVNELVKR 318
Cdd:COG5807 155 AHEIRNPLTSIKGFLQLLQESREDSER--EEYFNIIISEIDRINTIITELLVLS----KPKKFNFKKLNLNDVLEDVIAL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 319 M---ANVYPQTLKFYNQTHSSEVCLDVPSFKQLLHIFMDNA----HKYGRtcIALTLTETKSNLVLSIADDGIGIPEEEL 391
Cdd:COG5807 229 LsteAILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAieamETGGN--ITIKTYVEGDFVVISVKDEGIGIPEEVL 306
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 392 PHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:COG5807 307 EKIGEPFF------TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-430 |
3.09e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 77.12 E-value: 3.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 345 FKQLLHIFMDNAHKYGRT--CIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREI 422
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNI 84
|
....*...
gi 1374812345 423 SQQQHIDI 430
Cdd:cd16946 85 ALAHGGTI 92
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
43-456 |
1.18e-16 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 81.94 E-value: 1.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 43 ENRSINIMEEIKSSENQTNAEI-MNHGY------ILSDGYISVVNQDNIAIVKFATDVSY-NNMEQDYQANQYKKTIAYK 114
Cdd:COG5809 69 EKELREILKLLKEGESRDELEFeLRHKNgkrlefSSKLSPIFDQNGDIEGMLAISRDITErKRMEEALRESEEKFRLIFN 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 115 GHHFAMVslpIVWKNGEVVNL-QLYENVdFKYETFQilkwiLIGSTLFILVLIFYINNVmtriitspiLKLIQHIKETKE 193
Cdd:COG5809 149 HSPDGII---VTDLDGRIIYAnPAACKL-LGISIEE-----LIGKSILELIHSDDQENV---------AAFISQLLKDGG 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 194 TKDYRPVLVHKNDSYelKVLSTAFN---------------------EMMTKLGEHDEK-QRAFIMNAS--HELKTPITVI 249
Cdd:COG5809 211 IAQGEVRFWTKDGRW--RLLEASGApikkngevdgiviifrditerKKLEELLRKSEKlSVVGELAAGiaHEIRNPLTSL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 250 SSYSQMLKrfgkkDAKTLDES--IHAIHDEAQKMKYLTEQLLYFAQITEnkteRRLEKVNVADIVNELVKRMAnvyPQTL 327
Cdd:COG5809 289 KGFIQLLK-----DTIDEEQKtyLDIMLSELDRIESIISEFLVLAKPQA----IKYEPKDLNTLIEEVIPLLQ---PQAL 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 328 kFYNQTHSSEVCLDVPS-------FKQLLHIFMDNA----HKYGRTCIALTLTEtKSNLVLSIADDGIGIPEEELPHIFT 396
Cdd:COG5809 357 -LKNVQIELELEDDIPDilgdenqLKQVFINLLKNAieamPEGGNITIETKAED-DDKVVISVTDEGCGIPEERLKKLGE 434
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 397 RFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGGPHETIY 456
Cdd:COG5809 435 PFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQVSM 488
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
135-447 |
2.63e-16 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 81.61 E-value: 2.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 135 LQLYENVDFKYETFQI----LKWILIgsTLFILVLIFYinNVMTRIITSPILKLIQHIKETKETKDYRPVLVHKNDsyEL 210
Cdd:PRK15347 279 VTLYPRRNLANEALKPalqqLPFALL--ILVLLTSVLF--LLLRRYLAKPLWRFVDIINKTGPAALEPRLPENRLD--EL 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 211 KVLSTAFNEMMTKLGEH-DE---------------KQRAFIMNA---------SHELKTPITVISSYSQMLKRfgkkdaK 265
Cdd:PRK15347 353 GSIAKAYNQLLDTLNEQyDTlenkvaertqalaeaKQRAEQANKrksehlttiSHEIRTPLNGVLGALELLQN------T 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 266 TLDESIHAIHDEAQK-MKYLTE---QLLYFAQITENKTERRLEKVN---VADIVNELVKRMANVYPQTLK-FYNQTHSSE 337
Cdd:PRK15347 427 PLTAEQMDLADTARQcTLSLLAiinNLLDFSRIESGQMTLSLEETAllpLLDQAMLTIQGPAQSKSLTLRtFVGAHVPLY 506
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 338 VCLDVPSFKQLLHIFMDNAHKY---GRtcIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKarsrKTGGSGL 414
Cdd:PRK15347 507 LHLDSLRLRQILVNLLGNAVKFtetGG--IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGL 580
|
330 340 350
....*....|....*....|....*....|...
gi 1374812345 415 GLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:PRK15347 581 GLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-425 |
8.30e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 72.87 E-value: 8.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 346 KQLLHIFMDNAHKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSrkTGGSGLGLSIAREISQQ 425
Cdd:cd16950 2 KRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISDA 79
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
240-448 |
9.99e-16 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 79.01 E-value: 9.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 240 HELKTPITVISSYSQMLKrfGKKDAKtlDESIHAIHDEAQKMKYLTEQLLYFAQITENKTErrleKVNVADIVNELVKRM 319
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQ--PGIEDK--EEYFDIMLSELDRIESIISEFLALAKPQAVNKE----KENINELIQDVVTLL 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 320 ---ANVYPQTLKFYNQTHSSEVCLDVPSFKQLLHIFMDNA----HKYGrtCIALTLTETKSNLVLSIADDGIGIPEEELP 392
Cdd:COG5805 368 eteAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAieamPNGG--TITIHTEEEDNSVIIRVIDEGIGIPEERLK 445
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 393 HIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPK 448
Cdd:COG5805 446 KLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
234-447 |
1.02e-15 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 79.60 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 234 FIMNASHELKTPITVISSYSQMLkrfgkkdaktLDESIhaihdEAQKMKYLteQLLYFAQIT----------ENKTERR- 302
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRIL----------LDTEL-----TAEQRKYL--KTIHVSAITlgnifndiidMDKMERRk 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 303 ----LEKVNVADIVNELV---KRMANvyPQTLKFYNQTHSS---EVCLDVPSFKQLLHIFMDNAHKYGR------TCIAl 366
Cdd:PRK11091 349 lqldNQPIDFTDFLADLEnlsGLQAE--QKGLRFDLEPLLPlphKVITDGTRLRQILWNLISNAVKFTQqggvtvRVRY- 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 367 tltETKSNLVLSIADDGIGIPEEELPHIFTRFYRV-DKARSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLI 445
Cdd:PRK11091 426 ---EEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLT 502
|
..
gi 1374812345 446 IP 447
Cdd:PRK11091 503 IH 504
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
239-447 |
1.10e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 79.06 E-value: 1.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 239 SHELKTPITVISSYSqmlKRFGKK-DAKTLD-ESIHAIHDEAQKMKYLTEQLLYFAQitenKTERRLEKVNVADIVN--- 313
Cdd:PRK10364 245 AHEIRNPLSSIKGLA---KYFAERaPAGGEAhQLAQVMAKEADRLNRVVSELLELVK----PTHLALQAVDLNDLINhsl 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 314 ELVKRMANVYPQTLKFYNQTHSSEVCLDVPSFKQ-LLHIFMDNAHKYGRT-CIALTLTETKSNLVLSIADDGIGIPEEEL 391
Cdd:PRK10364 318 QLVSQDANSREIQLRFTANDTLPEIQADPDRLTQvLLNLYLNAIQAIGQHgVISVTASESGAGVKISVTDSGKGIAADQL 397
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 392 PHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:PRK10364 398 EAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-444 |
4.43e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 71.39 E-value: 4.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 341 DVPSFKQLLHIFMDNAHKYGRT--CIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSI 418
Cdd:cd16947 17 NTEALQRILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTI 96
|
90 100
....*....|....*....|....*.
gi 1374812345 419 AREISQQQHIDIQVKSQVNVGTTFTL 444
Cdd:cd16947 97 TKRLAESMGGSIYVNSKPYEKTVFTV 122
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
1-448 |
1.03e-14 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 75.82 E-value: 1.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 1 MRLRTRIQLYITLMTVIVVICVNILVYFMFKHYALASELNQLENRSINIMEEIKSSENQTNAEIMNHGYILSDGYISVVN 80
Cdd:COG2972 6 SLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 81 QDNIAIVKFATDVSYNNMEQDYQANQYKKTIAYKGHHFAMVSLPIVWKNGEVVNLQLYENVDFKYETFQILKWILIGSTL 160
Cdd:COG2972 86 LLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 161 FILVLIFYINnVMTRIITSPILKLIQHIKETkETKDYRPVLVHKNDsyELKVLSTAFNEMMTKLGE-HDEKQRAFIMNAS 239
Cdd:COG2972 166 LLLLALLLSY-LLSRSITRPIKRLKKAMKKV-EKGDLVRLEVSGND--EIGILARSFNEMVERIKElIEEVYELELEKKE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 240 HELKT------P------ITVISSYSQMLKrfgkkdaktldesihaiHDEAQKMkylTEQLLYFAQITENKTErrlEKVN 307
Cdd:COG2972 242 AELKAlqaqinPhflfntLNSIRWLAELED-----------------PEEAEEM---LEALSKLLRYSLSKGD---ELVT 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 308 VADIVnELVKRMANV----YPQTLKFynQTHSSEVCLDVPSFKQLLHIFMDNAHKYGRTC------IALTLTETKSNLVL 377
Cdd:COG2972 299 LEEEL-ELIKSYLEIqklrFGDRLEV--EIEIDEELLDLLIPKLILQPLVENAIEHGIEPkegggtIRISIRKEGDRLVI 375
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1374812345 378 SIADDGIGIPEEELPHIFTRFyrvdkarSRKTGGSGLGLSIAREISQQQHID---IQVKSQVNVGTTFTLIIPK 448
Cdd:COG2972 376 TVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPL 442
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
355-447 |
1.20e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 69.77 E-value: 1.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQVKS 434
Cdd:cd16939 11 NALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHGGHVECDD 90
|
90
....*....|...
gi 1374812345 435 QVNVGTTFTLIIP 447
Cdd:cd16939 91 SELGGACFRLTWP 103
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
239-450 |
2.73e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 74.11 E-value: 2.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 239 SHELKTPITVISSYSQMLKrfgkkdaktLDESIHAIHDEAQKMKYLTEQLLyfaqitenkteRRLEKVNVADIVNELVKR 318
Cdd:COG3290 197 RHDFRNHLHTISGLLQLGE---------YDEALEYIDEISEELQELIDSLL-----------SRIGNPVLAALLLGKAAR 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 319 MANVYPQtLKFYNQTHSSEVCLDVPSFKQLLHIFMDNA------HKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELP 392
Cdd:COG3290 257 ARERGID-LTIDIDSDLPDLPLSDTDLVTILGNLLDNAieavekLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLE 335
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1374812345 393 HIFTRFYRvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGG 450
Cdd:COG3290 336 KIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
153-422 |
3.67e-14 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 74.28 E-value: 3.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 153 WILIG-STLFILVLIFyinnVMTRIITSPILKLIQHIKETKETKDYRPVLVHKNDsyELKVLSTAFNEMMTKLGEHDEKQ 231
Cdd:PRK10549 167 WLIVAlSTLLAALATF----LLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRD--ELGRLAQDFNQLASTLEKNEQMR 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 232 RAFIMNASHELKTPITVISsysqmlkrfGKKDA------KTLDESIHAIHDEAQKMKYLTEQLLYFAQITENKTERRLEK 305
Cdd:PRK10549 241 RDFMADISHELRTPLAVLR---------GELEAiqdgvrKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTP 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 306 VNVADIVNELVKRMANVYpqtlkfynQTHSSEVCLDVPS----------FKQLLHIFMDNAHKY----GRtcIALTLTET 371
Cdd:PRK10549 312 VDLVPLLEVAGGAFRERF--------ASRGLTLQLSLPDsatvfgdpdrLMQLFNNLLENSLRYtdsgGS--LHISAEQR 381
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1374812345 372 KSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREI 422
Cdd:PRK10549 382 DKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNI 432
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-440 |
4.13e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 68.20 E-value: 4.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 346 KQLLHIFMDNAHKY----GRTCIALtltETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKarsRKTGGSGLGLSIARE 421
Cdd:cd16940 15 FLLLRNLVDNAVRYspqgSRVEIKL---SADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKR 88
|
90
....*....|....*....
gi 1374812345 422 ISQQQHIDIQVKSQVNVGT 440
Cdd:cd16940 89 IVELHGGQIFLGNAQGGGL 107
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
234-447 |
5.56e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 74.39 E-value: 5.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 234 FIMNASHELKTPITVISSYSQMLKRFGKKDAKTLdESIHAIHDEAQKMKYLTEQLLYFAQITENKTERRLEKVNVADIVN 313
Cdd:PRK09959 715 FLATMSHEIRTPISSIMGFLELLSGSGLSKEQRV-EAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQ 793
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 314 ELVKRMANVYPQtlKFYNQTHSSE------VCLDVPSFKQLLHIFMDNAHKY---GRTCIALTLTETKSN---LVLSIAD 381
Cdd:PRK09959 794 NTCHSFGAIAAS--KSIALSCSSTfpdhylVKIDPQAFKQVLSNLLSNALKFtteGAVKITTSLGHIDDNhavIKMTIMD 871
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 382 DGIGIPEEELPHIFTRFYRVDKARSRKtgGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:PRK09959 872 SGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-447 |
8.54e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 67.06 E-value: 8.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 348 LLHIFMDNAHKY-GRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSrktgGSGLGLSIAREISQQQ 426
Cdd:cd16943 8 LLNLLVNAAQAMeGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYRIIQKH 83
|
90 100
....*....|....*....|.
gi 1374812345 427 HIDIQVKSQVNVGTTFTLIIP 447
Cdd:cd16943 84 GGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
355-447 |
3.74e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 65.49 E-value: 3.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYG--RTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKarSRKTGGSGLGLSIAREISQQQHIDIQV 432
Cdd:cd16923 11 NAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAIIELHGGSASA 88
|
90
....*....|....*
gi 1374812345 433 KSQvNVGTTFTLIIP 447
Cdd:cd16923 89 EYD-DNHDLFKVRLP 102
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
239-451 |
7.64e-13 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 70.86 E-value: 7.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 239 SHELKTPITVISSYSQM----LKRfGKKDAKTLDESIHAIHdeaqKMKYLTEQLLYFAQitenKTERRLEKVNVADIVNE 314
Cdd:PRK13837 458 AHNFNNILGAILGYAEMalnkLAR-HSRAARYIDEIISAGA----RARLIIDQILAFGR----KGERNTKPFDLSELVTE 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 315 LVK--RMANVYPQTLKFYNQTHSSEVCLDVPSFKQLLHIFMDNAHKY----GRTCIAL-------TLTETKSNL------ 375
Cdd:PRK13837 529 IAPllRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAmdgaGRVDISLsraklraPKVLSHGVLppgryv 608
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 376 VLSIADDGIGIPEEELPHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGGP 451
Cdd:PRK13837 609 LLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSK 678
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
355-447 |
1.42e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 63.84 E-value: 1.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYGRTC--IALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTgGSGLGLSIAREISQQQHIDIQV 432
Cdd:cd16948 16 NALKYSKQGgkIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYLVKKLCDKLGHKIDV 94
|
90
....*....|....*
gi 1374812345 433 KSQVNVGTTFTLIIP 447
Cdd:cd16948 95 ESEVGEGTTFTITFP 109
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-425 |
1.45e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 64.58 E-value: 1.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 345 FKQLLHIFMDNAHKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSrktgGSGLGLSIAREISQ 424
Cdd:cd16954 38 LMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVE 113
|
.
gi 1374812345 425 Q 425
Cdd:cd16954 114 Q 114
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
239-453 |
2.27e-12 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 69.29 E-value: 2.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 239 SHELKTPITVIssysqmlkrFGKKDAKTLD----ESIHAIHDEAQKMKYLT-----EQLLYFAQITENKTERRLEKVNVA 309
Cdd:PRK10490 672 SHDLRTPLTVL---------FGQAEILTLDlaseGSPHARQASEIRQQVLNttrlvNNLLDMARIQSGGFNLRKEWLTLE 742
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 310 DIVNELVKRMANvypqTLkfynqtHSSEVCLDVPSFKQLLHI-----------FMDNAHKYG--RTCIALTLTETKSNLV 376
Cdd:PRK10490 743 EVVGSALQMLEP----GL------SGHPINLSLPEPLTLIHVdgplfervlinLLENAVKYAgaQAEIGIDAHVEGERLQ 812
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1374812345 377 LSIADDGIGIPEEELPHIFTRFYRVDKARSrkTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGGPHE 453
Cdd:PRK10490 813 LDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETPPE 887
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
228-293 |
8.36e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 60.30 E-value: 8.36e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1374812345 228 DEKQRAFIMNASHELKTPITVISSYSQMLKRFGKKDAKtLDESIHAIHDEAQKMKYLTEQLLYFAQ 293
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEE-QREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
230-297 |
1.19e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 59.92 E-value: 1.19e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1374812345 230 KQRAFIMNASHELKTPITVISSYSQMLKRfgKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITEN 297
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-447 |
1.86e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 60.42 E-value: 1.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 347 QLLHIFMDNAHKYGRTC----IALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDkarSRKT-GGSGLGLSIARE 421
Cdd:cd16921 3 QVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIVRK 79
|
90 100
....*....|....*....|....*.
gi 1374812345 422 ISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:cd16921 80 IIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
180-430 |
3.36e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 65.04 E-value: 3.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 180 PILKLIQHIKE----TKETKDYRPvlvhkndSYELKVLSTAFNEMMTKLGEHDEKQRAFIMNASHELKTPITVISSYSQM 255
Cdd:PRK10815 218 PIEALAKQVREleegEREQLDPNP-------PRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRS 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 256 LkRFGKKDAKTLDESI--HAIHDEAQKMKYLteqlLYFAQI-TENKTERRlEKVNVADIVNELVKRMANVYpqtlkfynQ 332
Cdd:PRK10815 291 L-RSGKQMSVEQAEPImlEQISRISQQIGYY----LHRASMrSEHNLLSR-ELHSVAPLLDNLTSALNKVY--------Q 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 333 THSSEVCLDVPS----------FKQLLHIFMDNAHKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVD 402
Cdd:PRK10815 357 RKGVNITLDISPeitfvgekndFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRAD 436
|
250 260
....*....|....*....|....*...
gi 1374812345 403 KARSrktgGSGLGLSIAREISQQQHIDI 430
Cdd:PRK10815 437 TLRP----GQGLGLSVAREITEQYEGKI 460
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
341-447 |
3.37e-11 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 60.20 E-value: 3.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 341 DVPSFKQLLHIFMDNAHKY----GRTCIALTLTETKSNLvLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGL 416
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFtpdgGRIRCILEKFRLNRFL-LTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 1374812345 417 SIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
230-447 |
4.86e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 64.20 E-value: 4.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 230 KQRAFIMNAsHELKTPIT--VISSYSQML---KRFGKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITENKTERRLE 304
Cdd:PRK09303 151 KDRVLAMLA-HDLRTPLTaaSLALETLELgqiDEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTRWEALRFNPQ 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 305 KVNVADIVNELVKRMANVYpqtlkfynQTHSSEVCLDVPS-----------FKQLLHIFMDNAHKY---GRTcIALT-LT 369
Cdd:PRK09303 230 KLDLGSLCQEVILELEKRW--------LAKSLEIQTDIPSdlpsvyadqerIRQVLLNLLDNAIKYtpeGGT-ITLSmLH 300
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1374812345 370 ETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDkaRSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:PRK09303 301 RTTQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
209-424 |
2.26e-10 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 62.36 E-value: 2.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 209 ELKVLSTAFNEMMTKLGEHDEKQRAFIMNASHELKTPIT---VISSYSQMLKRFGKKDAKTLDEsIHAIHDEAQKmkyLT 285
Cdd:PRK10337 215 EVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAalkVQTEVAQLSDDDPQARKKALLQ-LHAGIDRATR---LV 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 286 EQLLYFAQITENKTERRLEKVNVADIVNELVkrmANVYPQTlkfynQTHSSEVCLDVPS-----------FKQLLHIFMD 354
Cdd:PRK10337 291 DQLLTLSRLDSLDNLQDVAEIPLEDLLQSAV---MDIYHTA-----QQAGIDVRLTLNAhpvirtgqpllLSLLVRNLLD 362
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYGRTCIALTLTETKSNLvlSIADDGIGIPEEELPHIFTRFYRvdkARSRKTGGSGLGLSIAREISQ 424
Cdd:PRK10337 363 NAIRYSPQGSVVDVTLNARNF--TVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAK 427
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
239-439 |
2.30e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 62.78 E-value: 2.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 239 SHELKTPITVISSYSQMLKRFG-KKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQitenKTERRLEKVNVADIVN---E 314
Cdd:COG4192 441 AHELNQPLNAMSMYLFSAKKALeQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSR----KSDTPLQPVDLRQVIEqawE 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 315 LVKRMANVYPQTLKFYNQThssEVCLDVPSFKQLLHIFMDNAHKYGRT--CIALTLTETKSNLVLSIADDGIGIPEeeLP 392
Cdd:COG4192 517 LVESRAKPQQITLHIPDDL---MVQGDQVLLEQVLVNLLVNALDAVATqpQISVDLLSNAENLRVAISDNGNGWPL--VD 591
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1374812345 393 HIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVG 439
Cdd:COG4192 592 KLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERG 632
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-422 |
2.36e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.58 E-value: 2.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 347 QLLHIFMDNAHKY-----GRtcIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYrVDKARSRKTG-GSGLGLSIAR 420
Cdd:cd16953 3 QVLRNLIGNAISFsppdtGR--ITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
..
gi 1374812345 421 EI 422
Cdd:cd16953 80 QI 81
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
230-297 |
7.57e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 54.88 E-value: 7.57e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1374812345 230 KQRAFIMNASHELKTPITVISSYSQMLKRfGKKDAKTlDESIHAIHDEAQKMKYLTEQLLYFAQITEN 297
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLD-TELSEEQ-REYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
367-447 |
7.61e-10 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 61.40 E-value: 7.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 367 TLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLII 446
Cdd:PRK11107 437 ALSNTKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHL 516
|
.
gi 1374812345 447 P 447
Cdd:PRK11107 517 P 517
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
347-447 |
3.01e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 59.22 E-value: 3.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 347 QLLHIFMDNAHKYGRT-CIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTGGSGLGLSIAREISQQ 425
Cdd:PRK10841 565 QVISNLLSNAIKFTDTgCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINM 644
|
90 100
....*....|....*....|..
gi 1374812345 426 QHIDIQVKSQVNVGTTFTLIIP 447
Cdd:PRK10841 645 MDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
375-447 |
3.86e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 54.31 E-value: 3.86e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1374812345 375 LVLSIADDGIGIPEEELPHIFTRFYRvdkarSRKTG-GSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-447 |
3.87e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 53.83 E-value: 3.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 364 IALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFT 443
Cdd:cd16915 26 VEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQSVERLGGSITVESEPGGGTTFS 100
|
....
gi 1374812345 444 LIIP 447
Cdd:cd16915 101 IRIP 104
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
228-447 |
6.49e-09 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 58.38 E-value: 6.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 228 DEKQRAFIMNASHELKTPITVISSYSQMLKrfGKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQITENKTERRL--EK 305
Cdd:PRK11466 441 SQAKSAFLAAMSHEIRTPLYGILGTAQLLA--DNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVsdEP 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 306 VNVADIVNELVKRM-ANVYPQTLKFynqthSSEVCLDVPS--------FKQLLHIFMDNAHKYG-RTCIALTLTETKSNL 375
Cdd:PRK11466 519 FEPRPLLESTLQLMsGRVKGRPIRL-----ATDIADDLPTalmgdprrIRQVITNLLSNALRFTdEGSIVLRSRTDGEQW 593
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1374812345 376 VLSIADDGIGIPEEELPHIFTRFYRVdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIP 447
Cdd:PRK11466 594 LVEVEDSGCGIDPAKLAEIFQPFVQV----SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
375-455 |
1.51e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 56.85 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 375 LVLSIADDGIGIPEEELPHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGGPHET 454
Cdd:PRK11086 468 LHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSN 541
|
.
gi 1374812345 455 I 455
Cdd:PRK11086 542 R 542
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-444 |
1.64e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 52.08 E-value: 1.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 346 KQLLHIFMDNA----HKYGrtCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARSRKTgGSGLGLSIARE 421
Cdd:cd16945 6 RQAINNLLDNAidfsPEGG--LIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQE 82
|
90 100
....*....|....*....|....
gi 1374812345 422 ISQQQHIDIQVKS-QVNVGTTFTL 444
Cdd:cd16945 83 VAQLHGGRITLRNrPDGVLAFLTL 106
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-446 |
1.75e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 52.07 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 348 LLHIFMDNAHKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYrvdkaRSRKTG-GSGLGLSIAREISQQQ 426
Cdd:cd16976 8 LLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSISYGIVEEH 82
|
90 100
....*....|....*....|
gi 1374812345 427 HIDIQVKSQVNVGTTFTLII 446
Cdd:cd16976 83 GGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-447 |
8.47e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 50.09 E-value: 8.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 366 LTLTETKSN---LVLSIADDGIGIPEEELPHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTF 442
Cdd:cd16920 26 LTIRTSPADdraVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICRSIIEAHGGRLSVESPAGGGATF 99
|
....*
gi 1374812345 443 TLIIP 447
Cdd:cd16920 100 QFTLP 104
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
246-451 |
1.02e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 52.70 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 246 ITVISSYSQMLKRFGKKDAKTLDESIHAIHDEAQKMkyLTE--QLLYfaqiteNKTERRLEKVNVADIVNELVKRMANVY 323
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREA--LAElrRLVR------GLRPPALDDLGLAAALEELAERLLRAA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 324 PQTLKFynqtHSSEVCLDVPSfKQLLHIF------MDNAHKYGR-TCIALTLTETKSNLVLSIADDGIGIPEEELPhift 396
Cdd:COG4585 141 GIRVEL----DVDGDPDRLPP-EVELALYrivqeaLTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEAAP---- 211
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1374812345 397 rfyrvdkarsrktgGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPKGGP 451
Cdd:COG4585 212 --------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-447 |
1.12e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 50.09 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 361 RTCIALTLTETKSNLVL--SIADDGIGIPEEELPHIFTRFYrvdkarSRKTGGSGLGLSIAREISQQQHIDIQVKSQVNv 438
Cdd:cd16918 28 RTQRQVTLGHPRHRLALrvSVIDNGPGIPPDLQDTIFYPMV------SGRENGTGLGLAIAQNIVSQHGGVIECDSQPG- 100
|
....*....
gi 1374812345 439 GTTFTLIIP 447
Cdd:cd16918 101 HTVFSVSLP 109
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
239-447 |
2.00e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 53.14 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 239 SHELKTPITVISSYS---QMLKRFGKKDAKTLDESIHAIHDEAQKMKYLTEQLLYFAQitENKTERRLekVNVadivNEL 315
Cdd:PRK13557 171 AHDFNNLLQVMSGYLdviQAALSHPDADRGRMARSVENIRAAAERAATLTQQLLAFAR--KQRLEGRV--LNL----NGL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 316 VKRMANVYPQTLKfYNQTHSSEVCLDVPSFK--------QLLHIFMdNAhkygRTCIA--LTLTETKSNL---------- 375
Cdd:PRK13557 243 VSGMGELAERTLG-DAVTIETDLAPDLWNCRidptqaevALLNVLI-NA----RDAMPegGRVTIRTRNVeiededlamy 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 376 ---------VLSIADDGIGIPEEELPHIFTRFYRvdkarSRKTG-GSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLI 445
Cdd:PRK13557 317 hglppgryvSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLY 391
|
..
gi 1374812345 446 IP 447
Cdd:PRK13557 392 FP 393
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
361-447 |
4.87e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 48.54 E-value: 4.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 361 RTCIALTLTETKSNLV--LSIADDGIGIPeeelPHIF-TRFYRVDKARSrktGGSGLGLSIAREISQQQHIDIQVKSQVN 437
Cdd:PRK11073 265 RTAFQLTLHGERYRLAarIDIEDNGPGIP----PHLQdTLFYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPG 337
|
90
....*....|
gi 1374812345 438 vGTTFTLIIP 447
Cdd:PRK11073 338 -HTEFSVYLP 346
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
300-447 |
9.93e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 47.98 E-value: 9.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 300 ERRLEKVNVADIVNELVKRMANVYPQtlkfynqtHSSEVCLDVPSfkqlLHIFMD--------------NAHKYGRT--- 362
Cdd:COG3920 353 SEDWEGVDLRDYLRELLEPLRDSYGG--------RGIRIELDGPD----VELPADaavplglilnelvtNALKHAFLsge 420
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 363 --CIALTLTETKSNLVLSIADDGIGIPEEelphiftrfyrVDKARSRktggsGLGLSIAREISQQQHIDIQVKSqvNVGT 440
Cdd:COG3920 421 ggRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTLELDR--PEGT 482
|
....*..
gi 1374812345 441 TFTLIIP 447
Cdd:COG3920 483 RVRITFP 489
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-233 |
7.31e-05 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 45.10 E-value: 7.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 1 MRLRTRIQLYITLMTVIVVICVNILVYFMFKHYALASELNQLENRSINIMEEIKSSENQTNAEIMNHGYILSDGYISVVN 80
Cdd:COG2770 56 LLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 81 QDNIAIVKFATDVSYNNMEQDYQANQYKKTIAYKGHH----FAMVSLPIVWKNGEVVNLQLYENVDFKYETFQILKWILI 156
Cdd:COG2770 136 LALALLALLLGLAAARLLLAALLALAAALALALGAGEllllADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLL 215
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1374812345 157 GSTLFILVLIFYINNVMTRIITSPILKLIQHIKETKETKDYRPVLVHKNDsyELKVLSTAFNEMMTKLGEHDEKQRA 233
Cdd:COG2770 216 LLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKD--EIGELARAFNRMADSLRESIEEAEE 290
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
149-229 |
1.99e-04 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 43.72 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 149 QILKWILIGSTLFILVLIFYINNVMTRIITSPILKLIQHIKETKETKDYRPVLVHKNDsyELKVLSTAFNEMMTKLGEHD 228
Cdd:COG3850 114 AINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRD--ELGTLARAFNRMADELQELY 191
|
.
gi 1374812345 229 E 229
Cdd:COG3850 192 A 192
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-425 |
2.80e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 40.14 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 345 FKQLLHIFMdNAHKYGRT--CIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYRVDKARsRKTGGSGLGLSIAREI 422
Cdd:cd16975 6 SRALINIIS-NACQYAPEggTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYIAKNL 83
|
...
gi 1374812345 423 SQQ 425
Cdd:cd16975 84 VEK 86
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
355-447 |
4.59e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 39.90 E-value: 4.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYGR-----TCIALTLTETKSNLVLSIADDGIGIPEEELPhiftrfyrvDKARSRKTGgsGLGLSIAREISQqqhiD 429
Cdd:COG2172 45 NAVRHAYggdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEG--GRGLFLIRRLMD----E 109
|
90
....*....|....*...
gi 1374812345 430 IQVKSQVNvGTTFTLIIP 447
Cdd:COG2172 110 VEYESDPG-GTTVRLVKR 126
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
355-447 |
9.14e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 38.30 E-value: 9.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 355 NAHKYGR-TCIALTLTETKSNLVLSIADDGIGIPEEelphiftrfyrvdkarsRKTGGSGLGLSIAREISQQQHIDIQVK 433
Cdd:cd16917 11 NALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERAELLGGTLTIG 73
|
90
....*....|....
gi 1374812345 434 SQVNVGTTFTLIIP 447
Cdd:cd16917 74 SRPGGGTRVTARLP 87
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
181-304 |
1.46e-03 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 41.27 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 181 ILKLIQhiketketKDYRpvlvhkNDSYELKVLSTAFnEMMTKLGEHDEKQRAFIMNASHELKTPIT----VISSYSQML 256
Cdd:PRK12364 113 VLKEIQ--------KDFP------SDEYSLDLLAEKF-LSFCKPNMSEGESLAALIKAAVELTTQEApdweFIAARLLML 177
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1374812345 257 kRFGKKDAKTLDEsiHAIHDEAQKMKYLTEQLLYFAQITENKTERRLE 304
Cdd:PRK12364 178 -QFSKKLGKSLEK--LGIHSFYDKIKYLTEEGLYGSYILEHYSREEIE 222
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
342-440 |
1.60e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 40.81 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 342 VPSFK--QLLHIF---MDNAHKYGR-TCIALTLTETKSNLVLSIADDGIGIPEeelphiftrfyrvDKARSRKtggsgLG 415
Cdd:PRK10600 462 VPSHQaiHLLQIAreaLSNALKHAQaSEVVVTVAQNQNQVKLSVQDNGCGVPE-------------NAERSNH-----YG 523
|
90 100
....*....|....*....|....*
gi 1374812345 416 LSIAREISQQQHIDIQVKSQVNVGT 440
Cdd:PRK10600 524 LIIMRDRAQSLRGDCRVRRRESGGT 548
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
377-424 |
2.11e-03 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 39.25 E-value: 2.11e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1374812345 377 LSIADDGIGIPEEELPHIFTRFYRVDKARSRKT-GGSGLGLSIAREISQ 424
Cdd:cd16933 58 VIVEDNGPGIPEEQIPKVFGKVLYGSKYHNKQSrGQQGLGISAAVLYSQ 106
|
|
| PRK04184 |
PRK04184 |
DNA topoisomerase VI subunit B; Validated |
368-424 |
2.49e-03 |
|
DNA topoisomerase VI subunit B; Validated
Pssm-ID: 235246 [Multi-domain] Cd Length: 535 Bit Score: 40.26 E-value: 2.49e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1374812345 368 LTETKSNLVLSIADDGIGIPEEELPHIFTRF-----YRVDKaRSRktGGSGLGLSIAREISQ 424
Cdd:PRK04184 68 VDEGKDHYRVTVEDNGPGIPPEEIPKVFGKLlygskFHNLR-QSR--GQQGIGISAAVLYAQ 126
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
332-448 |
3.15e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 39.82 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 332 QTHSSEVCLDVPSFKQLLHIFMDNA------HKYGRTCIALTLTETKSNLVLSIADDGIGIPEEELPHIFTRFYrvdKAR 405
Cdd:PRK15053 420 QLSQLPPGLDSTEFAAIVGNLLDNAfeaslrSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGV---STR 496
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1374812345 406 SRKTGGSGLGLSIAREISQQQHIDIQVKSQVNVGTTFTLIIPK 448
Cdd:PRK15053 497 ADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
175-229 |
4.08e-03 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 35.30 E-value: 4.08e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1374812345 175 RIITSPILKLIQHIKETKETKDYRPVLVHKNDsyELKVLSTAFNEMMTKLGEHDE 229
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRD--EIGELARAFNEMADRLEETIA 53
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
11-247 |
8.20e-03 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 38.29 E-value: 8.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 11 ITLMTVIVVICVNILVYFMFKhYALASELNQLENRSINIMEEIKSSENQTNAEIMNHGYILSDGYiSVVNQDNIAIVKfa 90
Cdd:NF038389 7 ITILFAIALVSVSALFLILLK-YQKENYNEELNKKYSLIANTLLQLYQKNINEEELEKYLKNFGF-MPITDKKLEKEI-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 91 tdvsynnmeqdyQANQYKKTIAYKGHHFAMVSLP-----IVWKNGEVVnlqLYEnvDFKYETFQILKWILIGSTLFILVL 165
Cdd:NF038389 83 ------------LEIGKNKFILKENGSFRILKYNdkiylLIKNDGFSL---LLE--DNEKKSYRYYYIIVFFIFLILLLL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374812345 166 IFYINnVMTRIitSPILKLIQHIKETKETKDYRPVLVHKNDsyELKVLSTAFNEMMTKLGEHDEKQRAFIMNASHELKTP 245
Cdd:NF038389 146 ILYIS-VLKSL--KPLKKLKKQIKKFANGDFDFIKSESNGD--EIGEVANEFDKAVKKIKALNESRQLFLRNIMHELKTP 220
|
..
gi 1374812345 246 IT 247
Cdd:NF038389 221 IT 222
|
|
| |
