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Conserved domains on  [gi|1376705989|gb|PTP01683|]
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aldehyde-activating protein [Vibrio splendidus]

Protein Classification

GFA family protein( domain architecture ID 10007990)

GFA family protein similar to bacterial glutathione-dependent formaldehyde-activating enzyme, which catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione, and to eukaryotic centromere protein V, which plays a role in the distribution of pericentromeric heterochromatin in interphase nuclei

CATH:  2.170.150.70
Gene Ontology:  GO:0016846|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
16-138 7.08e-26

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443005  Cd Length: 132  Bit Score: 94.70  E-value: 7.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376705989  16 CRCGAVNLVCRGEPQRTSVCHCYECQKRTGSVFGVQARFPIKQVTL-NGE--VTSFSRisdkGSEVTYQFCPKCGTTMLL 92
Cdd:COG3791     8 CLCGAVRFEVDGPPLRVGACHCSICRKATGSAFAAVALVPADAFRLtSGEdaLTTYRS----SATAERHFCPTCGSPLFY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1376705989  93 QSVAAADFYIVPLGLFKEQDFPLPSFSVYEERKHGWVKFDHQMSHY 138
Cdd:COG3791    84 RRRGGPGLVAVNAGLLDDPDGLPPTAHIFTSSKPPWVEIPDGLPQF 129
 
Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
16-138 7.08e-26

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443005  Cd Length: 132  Bit Score: 94.70  E-value: 7.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376705989  16 CRCGAVNLVCRGEPQRTSVCHCYECQKRTGSVFGVQARFPIKQVTL-NGE--VTSFSRisdkGSEVTYQFCPKCGTTMLL 92
Cdd:COG3791     8 CLCGAVRFEVDGPPLRVGACHCSICRKATGSAFAAVALVPADAFRLtSGEdaLTTYRS----SATAERHFCPTCGSPLFY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1376705989  93 QSVAAADFYIVPLGLFKEQDFPLPSFSVYEERKHGWVKFDHQMSHY 138
Cdd:COG3791    84 RRRGGPGLVAVNAGLLDDPDGLPPTAHIFTSSKPPWVEIPDGLPQF 129
GFA pfam04828
Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step ...
 34-124 6.30e-20

Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.


Pssm-ID: 428146  Cd Length: 93  Bit Score: 78.17  E-value: 6.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376705989  34 VCHCYECQKRTGSVFGVQARFPIKQVTL-NGEVTSFSRISDKGSEVTYQFCPKCGTTMLLQSVAAADFYIVPLGLFKEQD 112
Cdd:pfam04828   2 LCHCRDCQRRSGSAFAANAVVPKEALRLtSGELKEYTDTGDSGNTVTRYFCPNCGTPLYSESTAAPGVIIVRVGTLDDPD 81

                          90
                  ....*....|..
gi 1376705989 113 FPLPSFSVYEER 124
Cdd:pfam04828  82 QLKPVAEIWTKS 93
 
Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
16-138 7.08e-26

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443005  Cd Length: 132  Bit Score: 94.70  E-value: 7.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376705989  16 CRCGAVNLVCRGEPQRTSVCHCYECQKRTGSVFGVQARFPIKQVTL-NGE--VTSFSRisdkGSEVTYQFCPKCGTTMLL 92
Cdd:COG3791     8 CLCGAVRFEVDGPPLRVGACHCSICRKATGSAFAAVALVPADAFRLtSGEdaLTTYRS----SATAERHFCPTCGSPLFY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1376705989  93 QSVAAADFYIVPLGLFKEQDFPLPSFSVYEERKHGWVKFDHQMSHY 138
Cdd:COG3791    84 RRRGGPGLVAVNAGLLDDPDGLPPTAHIFTSSKPPWVEIPDGLPQF 129
GFA pfam04828
Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step ...
 34-124 6.30e-20

Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.


Pssm-ID: 428146  Cd Length: 93  Bit Score: 78.17  E-value: 6.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376705989  34 VCHCYECQKRTGSVFGVQARFPIKQVTL-NGEVTSFSRISDKGSEVTYQFCPKCGTTMLLQSVAAADFYIVPLGLFKEQD 112
Cdd:pfam04828   2 LCHCRDCQRRSGSAFAANAVVPKEALRLtSGELKEYTDTGDSGNTVTRYFCPNCGTPLYSESTAAPGVIIVRVGTLDDPD 81

                          90
                  ....*....|..
gi 1376705989 113 FPLPSFSVYEER 124
Cdd:pfam04828  82 QLKPVAEIWTKS 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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