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Conserved domains on  [gi|1376712955|gb|PTP08590|]
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DUF2860 domain-containing protein [Vibrio splendidus]

Protein Classification

porin family protein( domain architecture ID 229388)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
OM_channels super family cl21487
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
27-331 1.43e-91

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


The actual alignment was detected with superfamily member pfam11059:

Pssm-ID: 473880  Cd Length: 297  Bit Score: 275.01  E-value: 1.43e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955  27 GFSGNMTFLTGFTANSSNLDVGQSNHQSqaDLMSSGNTEAEGMVAVLGSVQYTFGALNHkQFFLGTSRDDIITGTLAFEV 106
Cdd:pfam11059   1 GFSGTISLGVGVRSIKSNFNTDNNDHIS--SLNQSPESDSSFLPAPLGEIQYTFASGNT-QIFIGTSRGDVITGTFALEL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955 107 GYRQQVESGMVVDFSILPTLISGEVWDDPYAVDSNRKETDLTGTVVRMQLSRIMGSNFNLDVASGESDVKKENTGlkglG 186
Cdd:pfam11059  78 GYRQQLENRGVISFSYLPTILSGEVWEDPYLTGTARTETDESGNGFRLQLSNILGSNFTLDYAYAKQDIDNEKSG----G 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955 187 LTEEERALMIRERKYFYLKSGYQYFLkDGSGILTPSMNVFSSDSEGDALSFLSLGAEINLAKRYGNHGLALTLNAAKRSY 266
Cdd:pfam11059 154 LSAAQQASLKRDGNYHYLELEYRQPL-SREITLTPSLIYTRRDADGKAESYDQYGGQLSYNYFKGRHSLVLTASYAYREY 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1376712955 267 DKENPIFNKTREDKDFGAFVAYEYANIFDAKNWSLVSLLGAKTTNSNIEYYQSSQYVVSVGVDYK 331
Cdd:pfam11059 233 DAANPIFNKTRDDNGASLFATYEYNNFFGWQNWSFNALAGYEKTDSNITFYDESSYLISTGIGYK 297
 
Name Accession Description Interval E-value
DUF2860 pfam11059
Protein of unknown function (DUF2860); This bacterial family of proteins has no known function.
27-331 1.43e-91

Protein of unknown function (DUF2860); This bacterial family of proteins has no known function.


Pssm-ID: 431627  Cd Length: 297  Bit Score: 275.01  E-value: 1.43e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955  27 GFSGNMTFLTGFTANSSNLDVGQSNHQSqaDLMSSGNTEAEGMVAVLGSVQYTFGALNHkQFFLGTSRDDIITGTLAFEV 106
Cdd:pfam11059   1 GFSGTISLGVGVRSIKSNFNTDNNDHIS--SLNQSPESDSSFLPAPLGEIQYTFASGNT-QIFIGTSRGDVITGTFALEL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955 107 GYRQQVESGMVVDFSILPTLISGEVWDDPYAVDSNRKETDLTGTVVRMQLSRIMGSNFNLDVASGESDVKKENTGlkglG 186
Cdd:pfam11059  78 GYRQQLENRGVISFSYLPTILSGEVWEDPYLTGTARTETDESGNGFRLQLSNILGSNFTLDYAYAKQDIDNEKSG----G 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955 187 LTEEERALMIRERKYFYLKSGYQYFLkDGSGILTPSMNVFSSDSEGDALSFLSLGAEINLAKRYGNHGLALTLNAAKRSY 266
Cdd:pfam11059 154 LSAAQQASLKRDGNYHYLELEYRQPL-SREITLTPSLIYTRRDADGKAESYDQYGGQLSYNYFKGRHSLVLTASYAYREY 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1376712955 267 DKENPIFNKTREDKDFGAFVAYEYANIFDAKNWSLVSLLGAKTTNSNIEYYQSSQYVVSVGVDYK 331
Cdd:pfam11059 233 DAANPIFNKTRDDNGASLFATYEYNNFFGWQNWSFNALAGYEKTDSNITFYDESSYLISTGIGYK 297
 
Name Accession Description Interval E-value
DUF2860 pfam11059
Protein of unknown function (DUF2860); This bacterial family of proteins has no known function.
27-331 1.43e-91

Protein of unknown function (DUF2860); This bacterial family of proteins has no known function.


Pssm-ID: 431627  Cd Length: 297  Bit Score: 275.01  E-value: 1.43e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955  27 GFSGNMTFLTGFTANSSNLDVGQSNHQSqaDLMSSGNTEAEGMVAVLGSVQYTFGALNHkQFFLGTSRDDIITGTLAFEV 106
Cdd:pfam11059   1 GFSGTISLGVGVRSIKSNFNTDNNDHIS--SLNQSPESDSSFLPAPLGEIQYTFASGNT-QIFIGTSRGDVITGTFALEL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955 107 GYRQQVESGMVVDFSILPTLISGEVWDDPYAVDSNRKETDLTGTVVRMQLSRIMGSNFNLDVASGESDVKKENTGlkglG 186
Cdd:pfam11059  78 GYRQQLENRGVISFSYLPTILSGEVWEDPYLTGTARTETDESGNGFRLQLSNILGSNFTLDYAYAKQDIDNEKSG----G 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376712955 187 LTEEERALMIRERKYFYLKSGYQYFLkDGSGILTPSMNVFSSDSEGDALSFLSLGAEINLAKRYGNHGLALTLNAAKRSY 266
Cdd:pfam11059 154 LSAAQQASLKRDGNYHYLELEYRQPL-SREITLTPSLIYTRRDADGKAESYDQYGGQLSYNYFKGRHSLVLTASYAYREY 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1376712955 267 DKENPIFNKTREDKDFGAFVAYEYANIFDAKNWSLVSLLGAKTTNSNIEYYQSSQYVVSVGVDYK 331
Cdd:pfam11059 233 DAANPIFNKTRDDNGASLFATYEYNNFFGWQNWSFNALAGYEKTDSNITFYDESSYLISTGIGYK 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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