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Conserved domains on  [gi|1376737453|gb|PTP32598|]
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hypothetical protein CWN92_01940 [Vibrio splendidus]

Protein Classification

pyrimidine/purine nucleoside phosphorylase( domain architecture ID 10536379)

pyrimidine/purine nucleoside phosphorylase catalyzes the phosphorolysis of diverse nucleosides, such as uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine, yielding D-ribose 1-phosphate and the respective free bases; also catalyzes the reverse reactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 2-92 2.82e-45

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


:

Pssm-ID: 462023  Cd Length: 92  Bit Score: 140.70  E-value: 2.82e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  2 IKENTYFEGGVKSLAFNQA-GADVSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFDL 80
Cdd:pfam06865  1 KKANVYFDGKVTSRTFEFAdGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                         90
                 ....*....|..
gi 1376737453 81 QVKEATAYLCEY 92
Cdd:pfam06865 81 KVKEVTDYLCSY 92
 
Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 2-92 2.82e-45

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 140.70  E-value: 2.82e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  2 IKENTYFEGGVKSLAFNQA-GADVSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFDL 80
Cdd:pfam06865  1 KKANVYFDGKVTSRTFEFAdGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                         90
                 ....*....|..
gi 1376737453 81 QVKEATAYLCEY 92
Cdd:pfam06865 81 KVKEVTDYLCSY 92
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 1-91 1.06e-44

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 139.15  E-value: 1.06e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  1 MIKENTYFEGGVKSLAFNQA-GADVSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFD 79
Cdd:COG3123    8 MKKANVYFDGKVKSRTFIFAdGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPANSSFD 87

                         90
                 ....*....|..
gi 1376737453 80 LQVKEATAYLCE 91
Cdd:COG3123   88 LKVAEPTAYLCS 99
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
 5-92 8.38e-41

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 129.23  E-value: 8.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  5 NTYFEGGVKSLAFNQA-GADVSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFDLQVK 83
Cdd:cd20296    2 NVYFDGKVKSRTVIFAdGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEVK 81


                 ....*....
gi 1376737453 84 EATAYLCEY 92
Cdd:cd20296   82 EVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
1-93 4.33e-36

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 117.59  E-value: 4.33e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  1 MIKENTYFEGGVKSLAFNQAGAD-VSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFD 79
Cdd:PRK10579   1 MLQSNEYFSGKVKSIGFDSSSTGrASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFH 80

                         90
                 ....*....|....
gi 1376737453 80 LQVKEATAYLCEYL 93
Cdd:PRK10579  81 LQVAEPTSYLCRYL 94
 
Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 2-92 2.82e-45

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 140.70  E-value: 2.82e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  2 IKENTYFEGGVKSLAFNQA-GADVSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFDL 80
Cdd:pfam06865  1 KKANVYFDGKVTSRTFEFAdGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                         90
                 ....*....|..
gi 1376737453 81 QVKEATAYLCEY 92
Cdd:pfam06865 81 KVKEVTDYLCSY 92
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 1-91 1.06e-44

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 139.15  E-value: 1.06e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  1 MIKENTYFEGGVKSLAFNQA-GADVSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFD 79
Cdd:COG3123    8 MKKANVYFDGKVKSRTFIFAdGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPANSSFD 87

                         90
                 ....*....|..
gi 1376737453 80 LQVKEATAYLCE 91
Cdd:COG3123   88 LKVAEPTAYLCS 99
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
 5-92 8.38e-41

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 129.23  E-value: 8.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  5 NTYFEGGVKSLAFNQA-GADVSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFDLQVK 83
Cdd:cd20296    2 NVYFDGKVKSRTVIFAdGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEVK 81


                 ....*....
gi 1376737453 84 EATAYLCEY 92
Cdd:cd20296   82 EVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
1-93 4.33e-36

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 117.59  E-value: 4.33e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376737453  1 MIKENTYFEGGVKSLAFNQAGAD-VSVGVMAAGEYTFGTAAPEKMTVVKGALIVKRVGDDDWTTYQSGESFDVAGDSSFD 79
Cdd:PRK10579   1 MLQSNEYFSGKVKSIGFDSSSTGrASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFH 80

                         90
                 ....*....|....
gi 1376737453 80 LQVKEATAYLCEYL 93
Cdd:PRK10579  81 LQVAEPTSYLCRYL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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