NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1376752924|gb|PTP47654|]
View 

MFS transporter, partial [Vibrio splendidus]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 1000642)

efflux RND (Resistance-Nodulation-Division) transporter permease subunit is part of the RND family transport system, which is widespread especially among Gram-negative bacteria and catalyzes the active efflux of many antibiotics and chemotherapeutic agents; similar to Escherichia coli multidrug efflux pump RND permease AcrB, which is is the inner membrane component of a tripartite, proton dependent, drug efflux pump

Gene Ontology:  GO:0016020|GO:0022857
PubMed:  10941792|29577985
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AcrB super family cl34050
Multidrug efflux pump subunit AcrB [Defense mechanisms];
23-621 1.42e-130

Multidrug efflux pump subunit AcrB [Defense mechanisms];


The actual alignment was detected with superfamily member COG0841:

Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 408.34  E-value: 1.42e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   23 ASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSI 102
Cdd:COG0841      4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  103 SSRGLSQVTVTMKNNYGPDdlpQIWDELRRKVNDLKVELPPGVNDPQVI-DDFGDVYGILLAVTGDGYSYKELLDYID-Y 180
Cdd:COG0841     84 SSEGSSSITVEFELGTDID---EALVDVQNAVDRARSDLPEDVEPPGVTkVNPSDFPVMVLALSSDDLDELELSDYAErN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  181 LRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNVEQL 260
Cdd:COG0841    161 IKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEF 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  261 GDLIL-TEGGAqgLIYLKDVANVTRGYVEvPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGIDIS 339
Cdd:COG0841    241 ENIVIrTNDGS--VVRLGDVARVEDGAED-YRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELT 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  340 EVYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALGM 418
Cdd:COG0841    318 IVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRsWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGI 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  419 LVDNAIVVVEGI--LIgtQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEycgtLFT----VLLISLM 492
Cdd:COG0841    398 VVDDAIVVVENIerHM--EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQ----LFRqfalTVAIALL 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  493 LSWFTAISITPFFADIFFRGQKVDPDNEGKDPYNGM---VFVIYKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVKQAF 569
Cdd:COG0841    472 ISLFVALTLTPALCARLLKPHPKGKKGRFFRAFNRGfdrLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEF 551

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1376752924  570 FPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAGKGL 621
Cdd:COG0841    552 FPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSG 603
 
Name Accession Description Interval E-value
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
23-621 1.42e-130

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 408.34  E-value: 1.42e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   23 ASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSI 102
Cdd:COG0841      4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  103 SSRGLSQVTVTMKNNYGPDdlpQIWDELRRKVNDLKVELPPGVNDPQVI-DDFGDVYGILLAVTGDGYSYKELLDYID-Y 180
Cdd:COG0841     84 SSEGSSSITVEFELGTDID---EALVDVQNAVDRARSDLPEDVEPPGVTkVNPSDFPVMVLALSSDDLDELELSDYAErN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  181 LRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNVEQL 260
Cdd:COG0841    161 IKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEF 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  261 GDLIL-TEGGAqgLIYLKDVANVTRGYVEvPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGIDIS 339
Cdd:COG0841    241 ENIVIrTNDGS--VVRLGDVARVEDGAED-YRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELT 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  340 EVYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALGM 418
Cdd:COG0841    318 IVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRsWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGI 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  419 LVDNAIVVVEGI--LIgtQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEycgtLFT----VLLISLM 492
Cdd:COG0841    398 VVDDAIVVVENIerHM--EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQ----LFRqfalTVAIALL 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  493 LSWFTAISITPFFADIFFRGQKVDPDNEGKDPYNGM---VFVIYKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVKQAF 569
Cdd:COG0841    472 ISLFVALTLTPALCARLLKPHPKGKKGRFFRAFNRGfdrLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEF 551

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1376752924  570 FPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAGKGL 621
Cdd:COG0841    552 FPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSG 603
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 23-618 3.09e-87

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 293.05  E-value: 3.09e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   23 ASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSI 102
Cdd:pfam00873    2 SKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQ 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  103 SSRGLSQVTVTMKNNYGPDDLPQIWDElrrKVNDLKVELPPGVNDPQV-IDDFGDVYGILLAVTGDGYSYK--ELLDYID 179
Cdd:pfam00873   82 SSYGLSSITLTFELGTDIDIARQDVQN---RLQLATPLLPEGVQRPGIsVIKTSLGPIMVLAVTSPDGSYTqtDLRDYAD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  180 -YLRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNVE 258
Cdd:pfam00873  159 tNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  259 QLGDLILteGGAQG-LIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGID 337
Cdd:pfam00873  239 DFEKIIV--KNQDGsPVRLRDVATVELG-SELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVE 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  338 ISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIAL 416
Cdd:pfam00873  316 IVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQnWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAI 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  417 GMLVDNAIVVVEGI--LIGTQkGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEYCGTLFTVLLISLMLS 494
Cdd:pfam00873  396 GLVVDDAIVVVENIerVLEEN-GLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLS 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  495 WFTAISITPFFADIFFRGQKVDPDNEGKDPYNGMVFVI---YKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVKQAFFP 571
Cdd:pfam00873  475 VLVALTLTPALCATLLKPRREPKHGGFFRWFNRMFDRLtrgYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLP 554

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*..
gi 1376752924  572 SSTTPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAG 618
Cdd:pfam00873  555 EEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTG 601
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
24-620 1.93e-71

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 249.16  E-value: 1.93e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   24 SYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSIS 103
Cdd:NF033617     2 DVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  104 SRGLSQVTVTMKNNYGPDDLPQiwdELRRKVNDLKVELPPGVNDPQVIDDFG--DVYGILLAVTGDGYSYKELLDYID-Y 180
Cdd:NF033617    82 SLGYSTITLQFRLGTDLDVALS---EVQAAINAAQSLLPSEAPDPPVYRKANsaDTPIMYIGLTSEEMPRGQLTDYAErV 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  181 LRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNVEQL 260
Cdd:NF033617   159 LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  261 GDLILTEGGAQGLIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGIDISE 340
Cdd:NF033617   239 EDLVIKYADNGAPVRLGDVATVELG-AENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  341 VYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALGML 419
Cdd:NF033617   318 LYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRnLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLV 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  420 VDNAIVVVEGILIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTG----EYCGTLFTVLLISLmlsw 495
Cdd:NF033617   398 VDDAIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGrlfrEFAVTLAGAVIISG---- 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  496 FTAISITPFF-ADIFFRGQKVDPDNEGKDPYNGMVFVIYKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVKQAFFPSST 574
Cdd:NF033617   474 IVALTLTPMMcSRLLKANEKPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSED 553

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 1376752924  575 TPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAGKG 620
Cdd:NF033617   554 RGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVG 599
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
 23-618 4.10e-48

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 181.85  E-value: 4.10e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   23 ASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEkaiQQLTYVDEVNSI 102
Cdd:TIGR00915    2 AKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIE---QNMNGIDGLRYM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  103 SSR----GLSQVTVTMKNNYGPDdLPQIwdELRRKVNDLKVELPPGVNDPQV-IDDFGDVYGILLAVTGD--GYSYKELL 175
Cdd:TIGR00915   79 SSSsdsdGSMTITLTFEQGTDPD-IAQV--QVQNKLQLATPLLPQEVQRQGVrVEKASSNFLMVIGLVSDdgSMTKEDLS 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  176 DYID-YLRRELELVDGVSKVSVSGQQQeQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAG------AVRiGDEY-IR 247
Cdd:TIGR00915  156 DYAAsNMVDPLSRLEGVGDVQLFGSQY-AMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGqlgglpAVP-GQQLnAT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  248 IHPTGEFQNVEQLGDLILTEGGAQGLIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAE 327
Cdd:TIGR00915  234 IIAQTRLQTPEQFENILLKVNTDGSQVRLKDVARVELG-GENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAV 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  328 LKYQQPVGIDISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVV-LLFFMGVRSGLLIGLILLLTVFGTFIFMQYFKIDLQR 406
Cdd:TIGR00915  313 LEPFFPQGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVmYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINT 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  407 ISLGALVIALGMLVDNAIVVVEGI-LIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGE-YcgTLF 484
Cdd:TIGR00915  393 LTMFAMVLAIGLLVDDAIVVVENVeRVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAiY--RQF 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  485 TVLLISLM-LSWFTAISITPFFADIFFRGQKVDPDNEGKDPYNG---MVFVI----YKNFLEFCMKRAWLTMIVLVIGLG 556
Cdd:TIGR00915  471 SITIVSAMaLSVLVALILTPALCATMLKPIEKGEHHEKKGGFFGwfnRMFDSsthgYENGVGKILRRRGRYLLVYVLLVG 550

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1376752924  557 ASVYGFGFVKQAFFPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWL--SEQSEVEHITTTAG 618
Cdd:TIGR00915  551 GMVFLFVRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLlaKEKANVESVFTVNG 614
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
26-511 9.88e-42

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 162.31  E-value: 9.88e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   26 FIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSISSR 105
Cdd:PRK09579     7 FIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQ 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  106 GLSQVTVTMKNNYGPDDLpqiWDELRRKVNDLKVELPPGVNDPQVIDDFGDVYGIL-LAVTGDGYSYKELLDYID-YLRR 183
Cdd:PRK09579    87 NFSIISIYARIGADSDRL---FTELLAKANEVKNQLPQDAEDPVLSKEAADASALMyISFYSEEMSNPQITDYLSrVIQP 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  184 ELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRigDEYI--RIHPTGEFQNVEQLG 261
Cdd:PRK09579   164 KLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVK--GEYVvtSINASTELKSAEAFA 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  262 DLIL-TEGGAQglIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGIDISE 340
Cdd:PRK09579   242 AIPVkTSGDSR--VLLGDVARVEMG-AENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSI 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  341 VYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALGML 419
Cdd:PRK09579   319 AYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGaLRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLV 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  420 VDNAIVVVEGILIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEYCGTLFTVLLISLMLSWFTAI 499
Cdd:PRK09579   399 VDDAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVAL 478

                          490
                   ....*....|..
gi 1376752924  500 SITPFFADIFFR 511
Cdd:PRK09579   479 TLSPMMCALLLR 490
 
Name Accession Description Interval E-value
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
23-621 1.42e-130

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 408.34  E-value: 1.42e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   23 ASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSI 102
Cdd:COG0841      4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  103 SSRGLSQVTVTMKNNYGPDdlpQIWDELRRKVNDLKVELPPGVNDPQVI-DDFGDVYGILLAVTGDGYSYKELLDYID-Y 180
Cdd:COG0841     84 SSEGSSSITVEFELGTDID---EALVDVQNAVDRARSDLPEDVEPPGVTkVNPSDFPVMVLALSSDDLDELELSDYAErN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  181 LRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNVEQL 260
Cdd:COG0841    161 IKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEF 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  261 GDLIL-TEGGAqgLIYLKDVANVTRGYVEvPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGIDIS 339
Cdd:COG0841    241 ENIVIrTNDGS--VVRLGDVARVEDGAED-YRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELT 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  340 EVYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALGM 418
Cdd:COG0841    318 IVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRsWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGI 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  419 LVDNAIVVVEGI--LIgtQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEycgtLFT----VLLISLM 492
Cdd:COG0841    398 VVDDAIVVVENIerHM--EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQ----LFRqfalTVAIALL 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  493 LSWFTAISITPFFADIFFRGQKVDPDNEGKDPYNGM---VFVIYKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVKQAF 569
Cdd:COG0841    472 ISLFVALTLTPALCARLLKPHPKGKKGRFFRAFNRGfdrLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEF 551

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1376752924  570 FPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAGKGL 621
Cdd:COG0841    552 FPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSG 603
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 23-618 3.09e-87

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 293.05  E-value: 3.09e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   23 ASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSI 102
Cdd:pfam00873    2 SKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQ 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  103 SSRGLSQVTVTMKNNYGPDDLPQIWDElrrKVNDLKVELPPGVNDPQV-IDDFGDVYGILLAVTGDGYSYK--ELLDYID 179
Cdd:pfam00873   82 SSYGLSSITLTFELGTDIDIARQDVQN---RLQLATPLLPEGVQRPGIsVIKTSLGPIMVLAVTSPDGSYTqtDLRDYAD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  180 -YLRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNVE 258
Cdd:pfam00873  159 tNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  259 QLGDLILteGGAQG-LIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGID 337
Cdd:pfam00873  239 DFEKIIV--KNQDGsPVRLRDVATVELG-SELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVE 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  338 ISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIAL 416
Cdd:pfam00873  316 IVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQnWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAI 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  417 GMLVDNAIVVVEGI--LIGTQkGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEYCGTLFTVLLISLMLS 494
Cdd:pfam00873  396 GLVVDDAIVVVENIerVLEEN-GLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLS 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  495 WFTAISITPFFADIFFRGQKVDPDNEGKDPYNGMVFVI---YKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVKQAFFP 571
Cdd:pfam00873  475 VLVALTLTPALCATLLKPRREPKHGGFFRWFNRMFDRLtrgYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLP 554

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*..
gi 1376752924  572 SSTTPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAG 618
Cdd:pfam00873  555 EEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTG 601
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
24-620 1.93e-71

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 249.16  E-value: 1.93e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   24 SYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSIS 103
Cdd:NF033617     2 DVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  104 SRGLSQVTVTMKNNYGPDDLPQiwdELRRKVNDLKVELPPGVNDPQVIDDFG--DVYGILLAVTGDGYSYKELLDYID-Y 180
Cdd:NF033617    82 SLGYSTITLQFRLGTDLDVALS---EVQAAINAAQSLLPSEAPDPPVYRKANsaDTPIMYIGLTSEEMPRGQLTDYAErV 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  181 LRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNVEQL 260
Cdd:NF033617   159 LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  261 GDLILTEGGAQGLIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGIDISE 340
Cdd:NF033617   239 EDLVIKYADNGAPVRLGDVATVELG-AENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  341 VYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALGML 419
Cdd:NF033617   318 LYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRnLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLV 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  420 VDNAIVVVEGILIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTG----EYCGTLFTVLLISLmlsw 495
Cdd:NF033617   398 VDDAIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGrlfrEFAVTLAGAVIISG---- 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  496 FTAISITPFF-ADIFFRGQKVDPDNEGKDPYNGMVFVIYKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVKQAFFPSST 574
Cdd:NF033617   474 IVALTLTPMMcSRLLKANEKPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSED 553

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 1376752924  575 TPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAGKG 620
Cdd:NF033617   554 RGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVG 599
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
27-618 1.19e-59

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 215.66  E-value: 1.19e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   27 IRNKVISWMLSLIFLIGGVSAFFGLgRLED-PAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSISSR 105
Cdd:COG3696     10 LRNRLLVLLLTLLLAAAGIYSLRRL-PIDAfPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSISRF 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  106 GLSQVTVTMKnnYGPDDLpqiWDelRRKV----NDLKVELPPGVNdPQVIDDF---GDVYGILLAVTGDGYSYKELLDYI 178
Cdd:COG3696     89 GLSVVTVIFE--DGTDIY---WA--RQLVlerlQQVREQLPAGVT-PELGPIStglGEIYQYTLESDPGKYSLMELRTLQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  179 D-YLRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNV 257
Cdd:COG3696    161 DwVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  258 EQLGDLIL-TEGGAQglIYLKDVANVTRGYvEVPSNIIGYNGELALNLGVSFAQ-GVNLVAVGEDFDRRLAELKYQQPVG 335
Cdd:COG3696    241 EDIENIVVkTRNGTP--VLLRDVAEVRIGP-APRRGAATLNGEGEVVGGIVLMLkGENALEVIEAVKAKLAELKPSLPEG 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  336 IDISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVI 414
Cdd:COG3696    318 VKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGnLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAI 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  415 ALGMLVDNAIVVVEGIL------IGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPI----GLSedstgeycGTLF 484
Cdd:COG3696    398 DFGIIVDGAVVMVENILrrleenRAAGTPRERLEVVLEAAREVRRPIFFATLIIILVFLPIftleGVE--------GKLF 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  485 -----TV---LLISLMLSwftaISITPFFADIFFRGQKvdpdNEGKDPYNGMVFVIYKNFLEFCMKRAWLTMIVLVIGLG 556
Cdd:COG3696    470 rpmalTVifaLLGALLLS----LTLVPVLASLLLRGKV----PEKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLV 541

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1376752924  557 ASVYGFGFVKQAFFPssttPM----FQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAG 618
Cdd:COG3696    542 LALALFPRLGSEFLP----ELdegdLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTG 603
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
 23-618 4.10e-48

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 181.85  E-value: 4.10e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   23 ASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEkaiQQLTYVDEVNSI 102
Cdd:TIGR00915    2 AKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIE---QNMNGIDGLRYM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  103 SSR----GLSQVTVTMKNNYGPDdLPQIwdELRRKVNDLKVELPPGVNDPQV-IDDFGDVYGILLAVTGD--GYSYKELL 175
Cdd:TIGR00915   79 SSSsdsdGSMTITLTFEQGTDPD-IAQV--QVQNKLQLATPLLPQEVQRQGVrVEKASSNFLMVIGLVSDdgSMTKEDLS 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  176 DYID-YLRRELELVDGVSKVSVSGQQQeQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAG------AVRiGDEY-IR 247
Cdd:TIGR00915  156 DYAAsNMVDPLSRLEGVGDVQLFGSQY-AMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGqlgglpAVP-GQQLnAT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  248 IHPTGEFQNVEQLGDLILTEGGAQGLIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAE 327
Cdd:TIGR00915  234 IIAQTRLQTPEQFENILLKVNTDGSQVRLKDVARVELG-GENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAV 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  328 LKYQQPVGIDISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVV-LLFFMGVRSGLLIGLILLLTVFGTFIFMQYFKIDLQR 406
Cdd:TIGR00915  313 LEPFFPQGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVmYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINT 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  407 ISLGALVIALGMLVDNAIVVVEGI-LIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGE-YcgTLF 484
Cdd:TIGR00915  393 LTMFAMVLAIGLLVDDAIVVVENVeRVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAiY--RQF 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  485 TVLLISLM-LSWFTAISITPFFADIFFRGQKVDPDNEGKDPYNG---MVFVI----YKNFLEFCMKRAWLTMIVLVIGLG 556
Cdd:TIGR00915  471 SITIVSAMaLSVLVALILTPALCATMLKPIEKGEHHEKKGGFFGwfnRMFDSsthgYENGVGKILRRRGRYLLVYVLLVG 550

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1376752924  557 ASVYGFGFVKQAFFPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWL--SEQSEVEHITTTAG 618
Cdd:TIGR00915  551 GMVFLFVRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLlaKEKANVESVFTVNG 614
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
26-511 9.88e-42

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 162.31  E-value: 9.88e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   26 FIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSISSR 105
Cdd:PRK09579     7 FIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQ 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  106 GLSQVTVTMKNNYGPDDLpqiWDELRRKVNDLKVELPPGVNDPQVIDDFGDVYGIL-LAVTGDGYSYKELLDYID-YLRR 183
Cdd:PRK09579    87 NFSIISIYARIGADSDRL---FTELLAKANEVKNQLPQDAEDPVLSKEAADASALMyISFYSEEMSNPQITDYLSrVIQP 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  184 ELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRigDEYI--RIHPTGEFQNVEQLG 261
Cdd:PRK09579   164 KLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVK--GEYVvtSINASTELKSAEAFA 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  262 DLIL-TEGGAQglIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGIDISE 340
Cdd:PRK09579   242 AIPVkTSGDSR--VLLGDVARVEMG-AENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSI 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  341 VYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALGML 419
Cdd:PRK09579   319 AYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGaLRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLV 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  420 VDNAIVVVEGILIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEYCGTLFTVLLISLMLSWFTAI 499
Cdd:PRK09579   399 VDDAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVAL 478

                          490
                   ....*....|..
gi 1376752924  500 SITPFFADIFFR 511
Cdd:PRK09579   479 TLSPMMCALLLR 490
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
 19-619 1.78e-40

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 158.77  E-value: 1.78e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   19 ITGVASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDE 98
Cdd:TIGR00914    2 IERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLET 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   99 VNSISSRGLSQVTVTMKNNygpDDLPQIWDELRRKVNDLKVELPPGVnDPQVIDD---FGDVYGILL-----AVTGDGYS 170
Cdd:TIGR00914   82 TRSLSRYGLSQVTVIFKDG---TDLYFARQLVNERLQQARDNLPEGV-SPEMGPIstgLGEIFLYTVeaeegARKKDGGA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  171 YK-----ELLDYIdyLRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEY 245
Cdd:TIGR00914  158 YTltdlrTIQDWI--IRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQ 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  246 IRIHPTGEFQNVEQLGDLILTEGgaQGL-IYLKDVANVTRGYvEVPSNIIGYNGELALnLGVSFAQ-GVNLVAVGEDFDR 323
Cdd:TIGR00914  236 YLVRAPGQVQSMDDIRNIVIATG--EGVpIRIRDVARVQIGK-ELRTGAATENGKEVV-LGTVFMLiGENSRTVAQAVGD 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  324 RLAELKYQQPVGIDISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFMG-VRSGLLIGLILLLTVFGTFIFMQYFKI 402
Cdd:TIGR00914  312 KLETINKTLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGnIRAALIAATVIPLSLLITFIGMVFQGI 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  403 DLQRISLGALviALGMLVDNAIVVVEGIL-----IGTQKGR-----TRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLS 472
Cdd:TIGR00914  392 SANLMSLGAL--DFGLIVDGAVVIVENAHrrlaeAQHHHGRqltlkERLHEVFAASREVRRPLIFGQLIITLVFLPIFTL 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  473 EDSTGEYCGTLFTVLLISLMLSWFTAISITPFFADIFFRGqKVdpdNEGKDPYNGMVFVIYKNFLEFCMKRAWLTMIVLV 552
Cdd:TIGR00914  470 TGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIRG-KV---AEKENRLMRVLKRRYEPLLERVLAWPAVVLGAAA 545

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376752924  553 IGLGASVYGFGFVKQAFFPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAGK 619
Cdd:TIGR00914  546 VSIVLVVWIASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGT 612
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
22-618 3.80e-40

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 157.71  E-value: 3.80e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   22 VASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNS 101
Cdd:PRK09577     1 MARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  102 ISSRGLSQVTVTMKNNYGPDdLPQIwdELRRKVNDLKVELPPGVN-DPQVIDDFGDVYGILLAVTGDG--YSYKELLDY- 177
Cdd:PRK09577    81 TSSAGQASLSLTFKQGVNAD-LAAV--EVQNRLKTVEARLPEPVRrDGIQVEKAADNIQLIVSLTSDDgrLTGVELGEYa 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  178 ----IDYLRRelelVDGVSKVSVSGQqqeqvfiEISMK------RISSLGLSPSTVFNLLSTQNivssaGAVRIGD---- 243
Cdd:PRK09577   158 sanvLQALRR----VEGVGKVQFWGA-------EYAMRiwpdpvKLAALGLTASDIASAVRAHN-----ARVTIGDigrs 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  244 ---EYIRIHPTGEFQNV----EQLGDLILTEGGAQGLIYLKDVANVTRGYVE--VPSNIigyNGELALNLGVSFAQGVNL 314
Cdd:PRK09577   222 avpDSAPIAATVFADAPlktpEDFGAIALRARADGSALYLRDVARIEFGGNDynYPSYV---NGKTATGMGIKLAPGSNA 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  315 VAVGEDFDRRLAELKYQQPVGIDISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVVLLFFM-GVRSGLLIGLILLLTVFGT 393
Cdd:PRK09577   299 VATEKRVRATMDELSRYFPPGVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMqNFRATLIPTLVVPVALLGT 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  394 FIFMQYFKIDLQRISLGALVIALGMLVDNAIVVVEGI-LIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLS 472
Cdd:PRK09577   379 FGVMLAAGFSINVLTMFGMVLAIGILVDDAIVVVENVeRLMVEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFF 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  473 EDSTGEYCGTLFTVLLISLMLSWFTAISITPFFADIFFRgqKVDPDNEGKDPYNGMV--FVI-----YKNFLEFCMKRAW 545
Cdd:PRK09577   459 GGAVGNIYRQFALSLAVSIGFSAFLALSLTPALCATLLK--PVDGDHHEKRGFFGWFnrFVArstqrYATRVGAILKRPL 536

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376752924  546 LTMIVLVIGLGASVYGFGFVKQAFFPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAG 618
Cdd:PRK09577   537 RWLVVYGALTAAAALLFTRLPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGG 609
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
22-620 6.04e-36

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 144.97  E-value: 6.04e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   22 VASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEkaiQQLTYVDEVNS 101
Cdd:PRK10555     1 MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIE---QNMTGLDNLMY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  102 ISSR--GLSQVTVTMKNNYGPDDlpqiwDELRRKV-NDLKV---ELPPGVNDPQV-IDDFGDVYGILLA-VTGDGYSYKE 173
Cdd:PRK10555    78 MSSQssGTGQASVTLSFKAGTDP-----DEAVQQVqNQLQSamrKLPQAVQNQGVtVRKTGDTNILTIAfVSTDGSMDKQ 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  174 llDYIDY----LRRELELVDGVSKVSVSGQQQeQVFIEISMKRISSLGLSPSTVFNLLSTQN---IVSSAGAVRIGDEYI 246
Cdd:PRK10555   153 --DIADYvasnIQDPLSRVNGVGDIDAYGSQY-SMRIWLDPAKLNSFQMTTKDVTDAIESQNaqiAVGQLGGTPSVDKQA 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  247 ---RIHPTGEFQNVEQLGDLILTEGGAQGLIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDR 323
Cdd:PRK10555   230 lnaTINAQSLLQTPEQFRDITLRVNQDGSEVTLGDVATVELG-AEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLN 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  324 RLAELKYQQPVGIDISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVVL-LFFMGVRSGLLIGLILLLTVFGTFIFMQYFKI 402
Cdd:PRK10555   309 RLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMyLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGY 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  403 DLQRISLGALVIALGMLVDNAIVVVEGI-LIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEYCG 481
Cdd:PRK10555   389 SINTLTMFAMVLAIGLLVDDAIVVVENVeRIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYR 468

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  482 TlFTVLLISLM-LSWFTAISITPFFADIFFRgqkvdPDNEGKDP--------YNGMV---FVIYKNFLEFCMKRAWLTMI 549
Cdd:PRK10555   469 Q-FSITIVSAMvLSVLVAMILTPALCATLLK-----PLKKGEHHgqkgffgwFNRMFnrnAERYEKGVAKILHRSLRWIL 542

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376752924  550 VLVIGLGASVYGFGFVKQAFFPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWL--SEQSEVEHITTTAGKG 620
Cdd:PRK10555   543 IYVLLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYftHEKDNVMSVFATVGSG 615
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
 24-575 1.87e-33

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 137.17  E-value: 1.87e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   24 SYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSIS 103
Cdd:PRK10614     5 ALFIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSS 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  104 SRGLSQVTVTMKNNygpDDLPQIWDELRRKVNDLKVELPPGV-NDPQVID-DFGDVYGILLAVTGDGYSYKELLDYID-Y 180
Cdd:PRK10614    85 SLGSTRIILQFDFD---RDINGAARDVQAAINAAQSLLPSGMpSRPTYRKaNPSDAPIMILTLTSDTYSQGQLYDFAStQ 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  181 LRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNVEQL 260
Cdd:PRK10614   162 LAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEY 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  261 GDLIL--TEGGAqglIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPVGIDI 338
Cdd:PRK10614   242 QPLIIhyNNGAA---VRLGDVATVTDS-VQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  339 SEVYNQPKEVNKSVSGFVVSLGQAVAIVI-VVLLFFMGVRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALG 417
Cdd:PRK10614   318 QIAQDRSPTIRASLEEVEQTLAISVALVIlVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  418 MLVDNAIVVVEGILIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTG----EYCGTLFTVLLISLML 493
Cdd:PRK10614   398 FVVDDAIVVLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGrlfrEFAVTLSVAIGISLLV 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  494 SwftaISITPFFADIFFRGQKVD--PDNEGkdpYNGMVFVIYKNF---LEFCMKRAWLTMIVLVIGLGASVYGFGFVKQA 568
Cdd:PRK10614   478 S----LTLTPMMCAWLLKSSKPReqKRLRG---FGRMLVALQQGYgrsLKWVLNHTRWVGVVLLGTIALNVWLYISIPKT 550


                   ....*..
gi 1376752924  569 FFPSSTT 575
Cdd:PRK10614   551 FFPEQDT 557
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
21-618 2.13e-29

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 124.46  E-value: 2.13e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   21 GVASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVN 100
Cdd:PRK10503    11 GPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMS 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  101 SISSRGLSQVTVTMKNNYGPDDLPQiwdELRRKVNDLKVELPPGVNDPQVIDDF--GDVYGILLAVTGDGYSYKELLDYI 178
Cdd:PRK10503    91 SQSSGGASVITLQFQLTLPLDVAEQ---EVQAAINAATNLLPSDLPNPPVYSKVnpADPPIMTLAVTSTAMPMTQVEDMV 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  179 DY-LRRELELVDGVSKVSVSGQQQEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSAGAVRIGDEYIRIHPTGEFQNV 257
Cdd:PRK10503   168 ETrVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSA 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  258 EQLGDLILT-EGGAQglIYLKDVANVTRGyveVPSNIIGY--NGELALNLGVSFAQGVNLVAVGEDFDRRLAELKYQQPV 334
Cdd:PRK10503   248 EEYRQLIIAyQNGAP--IRLGDVATVEQG---AENSWLGAwaNKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESLPK 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  335 GIDISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVVL-LFFMGVRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALV 413
Cdd:PRK10503   323 SVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIyLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALT 402

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  414 IALGMLVDNAIVVVEGILIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTG----EYCGTLFTVLLI 489
Cdd:PRK10503   403 IATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGrlfrEFAVTLAVAILI 482

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  490 SLMLSwftaISITPFFADIFFRGQKVDPDNEGKDPYNGM---VFVIYKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVK 566
Cdd:PRK10503   483 SAVVS----LTLTPMMCARMLSQESLRKQNRFSRASERMfdrVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIP 558

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1376752924  567 QAFFPSSTTPMFQVDVWMPEGTDIRATNTKLRVLESWLSEQSEVEHITTTAG 618
Cdd:PRK10503   559 KGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVG 610
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
22-621 1.29e-27

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 118.85  E-value: 1.29e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   22 VASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEK---AIQQLTYVDe 98
Cdd:PRK15127     1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQnmnGIDNLMYMS- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   99 vNSISSRGLSQVTVTMKNNYGPDDLP-QIWDELRRKVNDLKVELPP-GVNDPQVIDDFGDVYGIllaVTGDGYSYKEllD 176
Cdd:PRK15127    80 -SNSDSTGTVQITLTFESGTDADIAQvQVQNKLQLAMPLLPQEVQQqGVSVEKSSSSFLMVVGV---INTDGTMTQE--D 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  177 YIDYLRRELElvDGVSKVSVSGQQQ---EQVFIEISM--KRISSLGLSPSTVFNLLSTQNIVSSAGA------VRIGDEY 245
Cdd:PRK15127   154 ISDYVAANMK--DPISRTSGVGDVQlfgSQYAMRIWMnpNELNKFQLTPVDVINAIKAQNAQVAAGQlggtppVKGQQLN 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  246 IRIHPTGEFQNVEQLGDLILTEGGAQGLIYLKDVANVTRGyVEVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDRRL 325
Cdd:PRK15127   232 ASIIAQTRLTSTEEFGKILLKVNQDGSRVRLRDVAKIELG-GENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAEL 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  326 AELKYQQPVGIDISEVYNQPKEVNKSVSGFVVSLGQAVAIVIVVL-LFFMGVRSGLLIGLILLLTVFGTFIFMQYFKIDL 404
Cdd:PRK15127   311 AKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMyLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSI 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  405 QRISLGALVIALGMLVDNAIVVVEGI-LIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEYCGTl 483
Cdd:PRK15127   391 NTLTMFGMVLAIGLLVDDAIVVVENVeRVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQ- 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  484 FTVLLISLM-LSWFTAISITPFFADIFFRGQKVDPDNEGKDPYNGMVFVI-------YKNFLEFCMK---RAWLTMIVLV 552
Cdd:PRK15127   470 FSITIVSAMaLSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMfeksthhYTDSVGNILRstgRYLVLYLIIV 549

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1376752924  553 IGLGasvYGFGFVKQAFFPSSTTPMFQVDVWMPEG-TDIRATNTKLRVLESWLS-EQSEVEHITTTAGKGL 621
Cdd:PRK15127   550 VGMA---YLFVRLPSSFLPDEDQGVFLTMVQLPAGaTQERTQKVLNEVTDYYLTkEKNNVESVFAVNGFGF 617
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
27-446 7.56e-19

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 90.93  E-value: 7.56e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   27 IRNKVISWMLSLIFLIGGVSAFFGLGR----LEDPAFtikdAMVVTSYPGATPQQVEEEVTYPLEKAIQQLTYVDEVNSI 102
Cdd:COG0841    523 LRHRKLTLLVALALLALSVLLFGRLPTeffpEEDQGQ----IIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSV 598

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  103 SSRGLS-------QVTVTMKN-NYGPDDLPQIWDELRRKVNDLkvelpPGVN---DPQVIDDFGDVYGILLAVTGDGYsy 171
Cdd:COG0841    599 VGFSGGgsgsnsgTIFVTLKPwDERDRSADEIIARLREKLAKI-----PGARvfvFQPPAGGLGSGAPIEVQLQGDDL-- 671

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  172 KELLDYIDYLRRELELVDGVSKVSVSGQ-QQEQVFIEISMKRISSLGLSPSTVFNLLST---QNIVSSagaVRIGDEYIR 247
Cdd:COG0841    672 EELAAAAEKLLAALRQIPGLVDVRSDLQlGKPELQLDIDREKAAALGVTVADVASTLRAalgGRYVND---FNRGGREYD 748

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  248 I---HPTGEFQNVEQLGDL-ILTEGGAqgLIYLKDVANVTRGYveVPSNIIGYNGELALNLGVSFAQGVNLVAVGEDFDR 323
Cdd:COG0841    749 VrvqAPEEDRNSPEDLENLyVRTPDGE--MVPLSSVATIEEGT--GPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEE 824

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  324 RLAELKYQQPVGIDISEVYNQPKEVNKS-VSGFVV--------------SLGQAVAIVIVVLLFFMGVrsglliglilll 388
Cdd:COG0841    825 LAAELKLPPGVSIEFTGQAEEEQESFSSlGLAFLLalllvylvlaaqfeSFIQPLIILLTVPLALIGA------------ 892

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1376752924  389 tVFGTFIFMQYFKIdlqrISLGALVIALGMLVDNAIVVVEGILIGTQKGRTRMQAATD 446
Cdd:COG0841    893 -LLGLLLTGTPLNI----YSQIGLIMLIGIVVKNAILLVDFANQLREEGMSLREAILE 945
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 20-505 5.40e-08

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 56.15  E-value: 5.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924   20 TGVASYFIRNKVISWMLSLIFLIGGVSAFFGLGRLEDPAFTIKDAMVVTSYPGATPQQVEEEVTYPLEKAIQQltyVDEV 99
Cdd:pfam00873  517 AKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKE---KPEV 593

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  100 NSISSR-GLSQVTVTMKNNYG---------------PDDLPQIWDELRRKVNDLkvelpPGVN----DPQVIDDFGDVYG 159
Cdd:pfam00873  594 ESVFAVtGFAFSGDNNGPNSGdafislkpwkerpgpEKSVQALIERLRKALKQI-----PGANvflfQPIQLRGLGTISG 668

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  160 I--LLAVTGDGYSYKELLDYIDYLRRELELVDGVSKVSVSGQQ-QEQVFIEISMKRISSLGLSPSTVFNLLSTQNIVSSA 236
Cdd:pfam00873  669 FrsDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEdQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYV 748

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  237 GAV----RIGDEYIRiHPTGEFQNVEQLGDLILTEGGAQgLIYLKDVANVTRGYVevPSNIIGYNGELALNLGVSFAQGV 312
Cdd:pfam00873  749 NDFpeggRVYDVVVQ-LPEDFRSSPEDIGQLYVRNPYGK-MIPLSAFAKIEWGYG--PPSINRYNGFRSIVISGNVAAGD 824

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  313 NLVAVGEDFDRRLAELKYQQPVGIDISEVYNQPKEVNKSVSGFVvslgqAVAIVIVVLLFFMGVRSGLLIGLILLL---T 389
Cdd:pfam00873  825 SLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILI-----ALALLVVFLVLAALYESWSDPLSIMLTvplA 899

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924  390 VFGTFIFMQYFKIDLQRISLGALVIALGMLVDNAIVVVEGIL-IGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAP 468
Cdd:pfam00873  900 LVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANeLREQEGKSLEEAILEACRLRLRPILMTALAAILGVLP 979

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1376752924  469 IGLSEDSTGEYCGTLFTVLLISLMLSWFTAISITPFF 505
Cdd:pfam00873  980 LALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVF 1016
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 314-561 5.35e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 52.92  E-value: 5.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 314 LVAVGEDFDRRLAELKYQQPVGIDI----SEVYNQPKEVNKSvsgFVVSLGQA-VAIVIVVLLFFMGVRSGLLIGLILLL 388
Cdd:TIGR00921 153 VVPIYNDVERSLERTNPPSGKFLDVtgspAINYDIEREFGKD---MGTTMAISgILVVLVLLLDFKRWWRPLLPLVIILF 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 389 TVFGTFIFMQYFKIDLQRISLGALVIALGMLVDNAIVVVEGILIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAP 468
Cdd:TIGR00921 230 GVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAA 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 469 IGLSEDSTGEYCGTLftvLLISLMLSWFTAISITPFFADIFFRG-QKVDPDNEGKDPYNGMVFVIYKNFLEFCMKRAWLT 547
Cdd:TIGR00921 310 LALSEFPMVSEFGLG---LVAGLITAYLLTLLVLPALLQSIDIGrEKVKKEIIAIGGKSSEIEEELSKVLSITVRHPVPA 386

                         250
                  ....*....|....
gi 1376752924 548 MIVLVIGLGASVYG 561
Cdd:TIGR00921 387 LVAALIITGLGLYG 400
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
146-615 5.99e-07

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 52.55  E-value: 5.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 146 NDPQVI------DDFGDVYGILLAVTG--DGYSyKELLDYIDYLRRELELVDGVSKVsvsgqqqeqvfieismkrisslg 217
Cdd:COG1033    49 DDPSVQaydefeEEFGGDDTVVVAVEGkdDIFT-PETLEALRELTEELEEIPGVDSV----------------------- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 218 LSPSTVFNLLSTqnivssaGAVRIGDEYIRIHPTGEFQNVEQLGDLILTEGGAQGLIYLKDvANVTRGYVEVPSNIIGYN 297
Cdd:COG1033   105 TSLTNVRATEGT-------EDGLTVEPLIPDELPASPEELAELREKVLSSPLYVGRLVSPD-GKATLIVVTLDPDPLSSD 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 298 GELAlnlgvsfaqgvnlvAVGEDFDRRLAELKYQqpvGIDIsEVYNQPK---EVNKSVSG-FVVSLGQAVAIVIVVLLFF 373
Cdd:COG1033   177 LDRK--------------EVVAEIRAIIAKYEDP---GVEV-YLTGFPVlrgDIAEAIQSdLAIFFPLALLLILLLLFLF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 374 MG-VRSGLLIGLILLLTVFGTFIFMQYF--KIDLQRISLGALVIALGmlVDNAIVVVEGILIGTQKGRTRMQAATDIVTQ 450
Cdd:COG1033   239 FRsLRGVLLPLLVVLLAVIWTLGLMGLLgiPLSPLTILVPPLLLAIG--IDYGIHLLNRYREERRKGLDKREALREALRK 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 451 TKWPLLGATVIAVTAFAPIGLSEDSTGEYCGtlfTVLLISLMLSWFTAISITPFFAdIFFRGQKVDPDNEGKDPYNGMVF 530
Cdd:COG1033   317 LGPPVLLTSLTTAIGFLSLLFSDIPPIRDFG---IVAAIGVLLAFLTSLTLLPALL-SLLPRPKPKTRRLKKPPELGRLL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 531 viyKNFLEFCMKRAWLTMIVLVIGLGASVYGFGFVK-----QAFFPSST-------------TPMFQVDVWMPEGTDIRA 592
Cdd:COG1033   393 ---AKLARFVLRRPKVILVVALVLAVVSLYGISRLKveydfEDYLPEDSpirqdldfieenfGGSDPLEVVVDTGEPDGL 469

                         490       500
                  ....*....|....*....|....*..
gi 1376752924 593 TN----TKLRVLESWLSEQSEVEHITT 615
Cdd:COG1033   470 KDpevlKEIDRLQDYLESLPEVGKVLS 496
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
352-503 6.33e-03

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 39.84  E-value: 6.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376752924 352 VSGFVVSLGQAVAIVIVVLLF-FMGVRSGLLIGLILLLTVFGTFIFMQYFKIDLQRISLGALVIALGMLVDNAIVVVEGI 430
Cdd:COG1033   604 IESQIRSLLLALLLIFLLLLLaFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRY 683

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376752924 431 LIGTQKGRTRMQAATDIVTQTKWPLLGATVIAVTAFAPIGLSEDSTGEYCGTLftvLLISLMLSWFTAISITP 503
Cdd:COG1033   684 REERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLL---LALGLLVALLAALLLLP 753
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH