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Conserved domains on  [gi|1376770573|gb|PTP64910|]
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transcriptional regulator UhpA [Vibrio splendidus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10360 super family cl32505
transcriptional regulator UhpA;
1-195 1.65e-95

transcriptional regulator UhpA;


The actual alignment was detected with superfamily member PRK10360:

Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 276.09  E-value: 1.65e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIASIMLSV 80
Cdd:PRK10360    1 MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIAIKLATpmknkASLNQLTRRESEVCQLLATGLDV 160
Cdd:PRK10360   81 HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLAS-----GRQDPLTKRERQVAEKLAQGMAV 155

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1376770573 161 KSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAK 195
Cdd:PRK10360  156 KEIAAELGLSPKTVHVHRANLMEKLGVSNDVELAR 190
 
Name Accession Description Interval E-value
PRK10360 PRK10360
transcriptional regulator UhpA;
1-195 1.65e-95

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 276.09  E-value: 1.65e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIASIMLSV 80
Cdd:PRK10360    1 MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIAIKLATpmknkASLNQLTRRESEVCQLLATGLDV 160
Cdd:PRK10360   81 HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLAS-----GRQDPLTKRERQVAEKLAQGMAV 155

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1376770573 161 KSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAK 195
Cdd:PRK10360  156 KEIAAELGLSPKTVHVHRANLMEKLGVSNDVELAR 190
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-117 1.73e-35

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 121.08  E-value: 1.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPS---GIASIMLSV 80
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRrypDLKVIVLTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSAN 117
Cdd:cd17535    81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-199 2.28e-35

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 121.15  E-value: 2.28e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIpsgiasimlsv 80
Cdd:COG2197     1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL----------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  81 hdspamvekslelgakgylskrcspdeliqavhtsanggcyltpdiaiklatpmknkaslnqLTRRESEVCQLLATGLDV 160
Cdd:COG2197    70 --------------------------------------------------------------LTPREREVLRLLAEGLSN 87

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1376770573 161 KSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKLFTQ 199
Cdd:COG2197    88 KEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALR 126
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-112 4.81e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 93.76  E-value: 4.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLslETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSV 80
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL--EKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIrrrDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAI 110
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 140-197 9.12e-19

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 76.03  E-value: 9.12e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1376770573  140 LNQLTRRESEVCQLLATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKLF 197
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 2-101 3.74e-07

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 49.02  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIAS-----I 76
Cdd:TIGR02875   3 IRIVIADDNKEFCNLLKEYLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEIELSarprvI 82

                          90       100
                  ....*....|....*....|....*
gi 1376770573  77 MLSVHDSPAMVEKSLELGAKGYLSK 101
Cdd:TIGR02875  83 MLSAFGQEKITQRAVALGADYYVLK 107
 
Name Accession Description Interval E-value
PRK10360 PRK10360
transcriptional regulator UhpA;
1-195 1.65e-95

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 276.09  E-value: 1.65e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIASIMLSV 80
Cdd:PRK10360    1 MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIAIKLATpmknkASLNQLTRRESEVCQLLATGLDV 160
Cdd:PRK10360   81 HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLAS-----GRQDPLTKRERQVAEKLAQGMAV 155

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1376770573 161 KSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAK 195
Cdd:PRK10360  156 KEIAAELGLSPKTVHVHRANLMEKLGVSNDVELAR 190
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 4-194 2.68e-36

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 126.30  E-value: 2.68e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI-PSGIAS--IMLSV 80
Cdd:PRK10651    9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLrEKSLSGriVVFSV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIAIKLATPMK-----NKASLNQLTRRESEVCQLLA 155
Cdd:PRK10651   89 SNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRanratTERDVNQLTPRERDILKLIA 168

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1376770573 156 TGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELA 194
Cdd:PRK10651  169 QGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAA 207
PRK09483 PRK09483
response regulator; Provisional
 1-196 7.09e-36

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 125.22  E-value: 7.09e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIM 77
Cdd:PRK09483    1 MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKIlryTPDVKIIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  78 LSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIAIKLATPMKNKAS---LNQLTRRESEVCQLL 154
Cdd:PRK09483   81 LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIAQQMALSQIEPATenpFASLSERELQIMLMI 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1376770573 155 ATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKL 196
Cdd:PRK09483  161 TKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHL 202
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-117 1.73e-35

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 121.08  E-value: 1.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPS---GIASIMLSV 80
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRrypDLKVIVLTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSAN 117
Cdd:cd17535    81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-199 2.28e-35

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 121.15  E-value: 2.28e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIpsgiasimlsv 80
Cdd:COG2197     1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL----------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  81 hdspamvekslelgakgylskrcspdeliqavhtsanggcyltpdiaiklatpmknkaslnqLTRRESEVCQLLATGLDV 160
Cdd:COG2197    70 --------------------------------------------------------------LTPREREVLRLLAEGLSN 87

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1376770573 161 KSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKLFTQ 199
Cdd:COG2197    88 KEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALR 126
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-196 3.36e-33

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 117.51  E-value: 3.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLEtDITVVGeFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSV 80
Cdd:COG4566     2 VYIVDDDEAVRDSLAFLLESA-GLRVET-FASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELaarGSPLPVIFLTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTsangGCYLTPDIAIKLATPMKNKASLNQLTRRESEVCQLLATGLDV 160
Cdd:COG4566    80 HGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRR----ALARDRARRAERARRAELRARLASLTPREREVLDLVVAGLSN 155

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1376770573 161 KSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKL 196
Cdd:COG4566   156 KQIARELGISPRTVEVHRANVMEKLGARSLAELVRL 191
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
4-199 5.10e-30

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 109.94  E-value: 5.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIP-SGIAS--IMLSV 80
Cdd:PRK10403    9 VLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRrDGVTAqiIILTV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIAIKLAT--PMKNK-ASLNQLTRRESEVCQLLATG 157
Cdd:PRK10403   89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREreMFGAEeDPFSVLTERELDVLHELAQG 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1376770573 158 LDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKLFTQ 199
Cdd:PRK10403  169 LSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQ 210
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-112 4.81e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 93.76  E-value: 4.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLslETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSV 80
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL--EKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIrrrDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAI 110
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-112 1.09e-22

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 88.87  E-value: 1.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIM 77
Cdd:COG4565     3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELrarGPDVDVIV 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1376770573  78 LSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:COG4565    83 ITAARDPETVREALRAGVVDYLIKPFTFERLREAL 117
PRK15369 PRK15369
two component system response regulator;
2-193 4.32e-22

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 88.98  E-value: 4.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPS---GIASIML 78
Cdd:PRK15369    4 YKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQrwpAMNILVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIAIKLATPMKNKASLNQ--LTRRESEVCQLLAT 156
Cdd:PRK15369   84 TARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREAILALLNADDTNPplLTPRERQILKLITE 163

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1376770573 157 GLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVEL 193
Cdd:PRK15369  164 GYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAEL 200
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 2-193 1.25e-21

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 87.97  E-value: 1.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDE---SGLSLLEEIP---SGIAS 75
Cdd:PRK10840    4 MNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDkygDGITLIKYIKrhfPSLSI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  76 IMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVhTSANGGCYLTPDIAIKLATPM-KNKASLNQLTRRESEVCQLL 154
Cdd:PRK10840   84 IVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKAL-AALQKGKKFTPESVSRLLEKIsAGGYGDKRLSPKESEVLRLF 162

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1376770573 155 ATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVEL 193
Cdd:PRK10840  163 AEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIAL 201
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-113 3.78e-21

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 89.64  E-value: 3.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLEtDITVVgEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIM 77
Cdd:COG2204     2 MARILVVDDDPDIRRLLKELLERA-GYEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELralDPDLPVIL 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1376770573  78 LSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:COG2204    80 LTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVE 115
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 6-101 1.74e-20

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 81.74  E-value: 1.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEA-RLgLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSVH 81
Cdd:COG4753     4 IVDDEPLIREGLKRILEWEAGFEVVGEAENGEEAlEL-LEEHKPDLVITDINMPGMDGLELLEAIrelDPDTKIIILSGY 82

                          90       100
                  ....*....|....*....|
gi 1376770573  82 DSPAMVEKSLELGAKGYLSK 101
Cdd:COG4753    83 SDFEYAQEAIKLGADDYLLK 102
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
3-193 2.44e-20

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 84.56  E-value: 2.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRSGFAQLLSlETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIP----SGIAsIML 78
Cdd:PRK09958    2 NAIIIDDHPLAIAAIRNLLI-KNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRkrqySGII-IIV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIAIKLATPMKNKASLNQLTRRESEVCQLLATGL 158
Cdd:PRK09958   80 SAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1376770573 159 DVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVEL 193
Cdd:PRK09958  160 DNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDL 194
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 4-116 9.58e-20

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 80.47  E-value: 9.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI-PSGIAS--IMLSV 80
Cdd:cd19931     1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALrEEGVSAriVILTV 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSA 116
Cdd:cd19931    81 SDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAA 116
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 140-197 9.12e-19

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 76.03  E-value: 9.12e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1376770573  140 LNQLTRRESEVCQLLATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKLF 197
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-112 1.37e-18

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 80.25  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIAS---IM 77
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPppiIF 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1376770573  78 LSVHDSPAMveKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:COG3279    81 TTAYDEYAL--EAFEVNAVDYLLKPIDEERLAKAL 113
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 4-114 2.71e-18

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 76.54  E-value: 2.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPS---GIASIMLSV 80
Cdd:cd19930     1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREelpDTKVLIVTT 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHT 114
Cdd:cd19930    81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIRT 114
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
3-193 6.29e-18

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 77.99  E-value: 6.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIP---SGIASIMLS 79
Cdd:PRK09935    5 SVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKqiqSTVKVLFLS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  80 VHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSANGGCYLTPDIA--IKLATPMKNKASLNQLTRRESEVCQLLATG 157
Cdd:PRK09935   85 SKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFPSETLnyIKSNKCSTNSSTDTVLSNREVTILRYLVSG 164

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1376770573 158 LDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVEL 193
Cdd:PRK09935  165 LSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVEL 200
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-155 1.27e-17

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 77.30  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLEtDITVVgEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIM 77
Cdd:COG0745     1 MPRILVVEDDPDIRELLADALERE-GYEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLrarPSDIPIIM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  78 LSVHDSPAMVEKSLELGAKGYLSKRCSPDEL---IQAVHTSANGGCYLTPDIAIKLATPMKNKASLNQLTRRESEVCQLL 154
Cdd:COG0745    79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELlarIRALLRRRAAEVLRVGDLLDLAAREVTRDGEPVELTPKEFRLLELL 158


                  .
gi 1376770573 155 A 155
Cdd:COG0745   159 M 159
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 6-112 1.37e-17

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 75.07  E-value: 1.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQLLSLET-DITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSVH 81
Cdd:cd17536     3 IVDDEPLIREGLKKLIDWEElGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIrelYPDIKIIILSGY 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1376770573  82 DSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17536    83 DDFEYAQKAIRLGVVDYLLKPVDEEELEEAL 113
fixJ PRK09390
response regulator FixJ; Provisional
 3-196 1.50e-17

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 76.96  E-value: 1.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRSGFAQLLslETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIP---SGIASIMLS 79
Cdd:PRK09390    5 VVHVVDDDEAMRDSLAFLL--DSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKargSPLPVIVMT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  80 VH-DSPAMVEkSLELGAKGYLSKRCSPDELIQAVHTS------ANGGCYLTPDIAIKLATpmknkaslnqLTRRESEVCQ 152
Cdd:PRK09390   83 GHgDVPLAVE-AMKLGAVDFIEKPFEDERLIGAIERAlaqapeAAKSEAVAADIRARIAS----------LSERERQVMD 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1376770573 153 LLATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKL 196
Cdd:PRK09390  152 GLVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGSLSELVRM 195
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 6-101 3.09e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 73.42  E-value: 3.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQLLSLETDItvVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSVHD 82
Cdd:cd00156     2 IVDDDPAIRELLKSLLEREGYE--VDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLrelPPDIPVIVLTAKA 79

                          90
                  ....*....|....*....
gi 1376770573  83 SPAMVEKSLELGAKGYLSK 101
Cdd:cd00156    80 DEEDAVRALELGADDYLVK 98
GerE pfam00196
Bacterial regulatory proteins, luxR family;
143-197 5.10e-17

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 71.46  E-value: 5.10e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1376770573 143 LTRRESEVCQLLATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKLF 197
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 3-114 1.07e-16

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 75.20  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRSGFAQLLSlETDITVVgEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI-----PSGIASIM 77
Cdd:COG3437     8 TVLIVDDDPENLELLRQLLR-TLGYDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLradpsTRDIPVIF 85

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1376770573  78 LSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHT 114
Cdd:COG3437    86 LTALADPEDRERALEAGADDYLTKPFDPEELLARVRN 122
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
138-200 1.07e-16

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 74.41  E-value: 1.07e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376770573 138 ASLNQLTRRESEVCQLLATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKLFTQD 200
Cdd:COG2771   123 ARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRL 185
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-113 2.00e-16

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 72.19  E-value: 2.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSlETDITVVgEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI-----PSGIAS 75
Cdd:COG0784     5 GKRILVVDDNPDNRELLRRLLE-RLGYEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIralprLPDIPI 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1376770573  76 IMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:COG0784    83 IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALR 120
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 143-196 3.33e-16

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 69.49  E-value: 3.33e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1376770573 143 LTRRESEVCQLLATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKL 196
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAY 54
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 4-113 5.94e-15

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 68.29  E-value: 5.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLEtDITVVGeFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLE---EIPSGIASIMLSV 80
Cdd:cd17549     1 VLLVDDDADVREALQQTLELA-GFRVRA-FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAqirELDPDLPVILITG 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:cd17549    79 HGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVR 111
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-112 7.86e-15

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 69.60  E-value: 7.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSlETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI--PSGIASIML 78
Cdd:COG3707     3 GLRVLVVDDEPLRRADLREGLR-EAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQIseERPAPVILL 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:COG3707    82 TAYSDPELIERALEAGVSAYLVKPLDPEDLLPAL 115
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-112 8.76e-15

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 69.17  E-value: 8.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSlETDITVVgEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI-----PSGIAS 75
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLE-AAGYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLradprTADIPI 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1376770573  76 IMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:COG3706    79 IFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 2-112 8.87e-15

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 67.30  E-value: 8.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSlETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIML 78
Cdd:cd17542     1 KKVLIVDDAAFMRMMLKDILT-KAGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIkkiDPNAKVIMC 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17542    80 SAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAV 113
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 143-199 5.62e-14

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 64.21  E-value: 5.62e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1376770573 143 LTRRESEVCQLLATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELAKLFTQ 199
Cdd:COG5905    13 LTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALR 69
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 2-101 7.39e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 59.71  E-value: 7.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI----PSGIasIM 77
Cdd:cd17541     1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRImaerPTPV--VM 78

                          90       100
                  ....*....|....*....|....*.
gi 1376770573  78 LSVHDSP--AMVEKSLELGAKGYLSK 101
Cdd:cd17541    79 VSSLTEEgaEITLEALELGAVDFIAK 104
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 4-112 5.46e-11

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 57.08  E-value: 5.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLE-TDITVVGefnSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSG--IASIM 77
Cdd:cd17580     1 ILVVDDNEDAAEMLALLLELEgAEVTTAH---SGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLrelPWLanTPAIA 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1376770573  78 LSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17580    78 LTGYGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 6-112 3.50e-10

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 55.24  E-value: 3.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSVHD 82
Cdd:cd17532     3 IVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLsklAKPPLIVFVTAYD 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1376770573  83 SPAMveKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17532    83 EYAV--EAFELNAVDYLLKPFSEERLAEAL 110
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 6-113 1.65e-09

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 54.54  E-value: 1.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDhvivRSGFAQLL--SLET---DITVVgefNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI----PSgIASI 76
Cdd:COG4567     9 LVDD----DEAFARVLarALERrgfEVTTA---ASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALrerdPD-ARIV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1376770573  77 MLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:COG4567    81 VLTGYASIATAVEAIKLGADDYLAKPADADDLLAALE 117
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 4-112 2.40e-09

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 52.98  E-value: 2.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLslETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSV 80
Cdd:cd17537     3 VYVVDDDEAVRDSLAFLL--RSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELlarGSNIPIIFITG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17537    81 HGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAI 112
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 1-101 2.49e-09

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 55.19  E-value: 2.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVivrsGFAQLL----SLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIpSGIAS- 75
Cdd:COG5801     4 KIKVLIADDNR----EFCELLeeylSSQPDMEVVGVAYNGLEALELIEEKKPDVVILDIIMPHLDGLGVLEKL-REMNLe 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1376770573  76 -----IMLSVHDSPAMVEKSLELGAKGYLSK 101
Cdd:COG5801    79 krpkvIMLTAFGQEDITQRAVELGADYYILK 109
PRK11697 PRK11697
two-component system response regulator BtsR;
1-66 6.02e-09

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 54.08  E-value: 6.02e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEArlgLPSCH---PDVVILDISMQDESGLSLL 66
Cdd:PRK11697    1 MIKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEA---IGAIHrlkPDVVFLDIQMPRISGLELV 66
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 6-112 8.41e-09

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 51.33  E-value: 8.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQLLSLETDItvVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSG---IASIMLSVHD 82
Cdd:cd17624     3 LVEDDALLGDGLKTGLRKAGYA--VDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQgqsLPVLILTARD 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1376770573  83 SPAMVEKSLELGAKGYLSKRCSPDEL---IQAV 112
Cdd:cd17624    81 GVDDRVAGLDAGADDYLVKPFALEELlarLRAL 113
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-101 9.93e-09

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 51.48  E-value: 9.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPS-GIAS--IML 78
Cdd:cd19925     1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAaGHDVdvIVV 80

                          90       100
                  ....*....|....*....|...
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSK 101
Cdd:cd19925    81 TAANDVETVREALRLGVVDYLIK 103
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 3-111 9.98e-09

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 51.29  E-value: 9.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHvivrSGFAQLL--SLET-DITVVgEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI----PS---- 71
Cdd:cd17563     2 SLLLVDDD----EVFAERLarALERrGFEVE-TAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLralqPDariv 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1376770573  72 ---GIASImlsvhdsPAMVEkSLELGAKGYLSKRCSPDELIQA 111
Cdd:cd17563    77 vltGYASI-------ATAVE-AIKLGADDYLAKPADADEILAA 111
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 49-108 1.15e-08

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 51.09  E-value: 1.15e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1376770573  49 DVVILDISMQDESGLSLLEEIPS--GIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDEL 108
Cdd:cd17584    46 DLVITDVHMPDMDGFEFLELIRLemDLPVIMMSADGSTSTVMKGLAHGACDYLLKPVSIEDL 107
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-109 1.38e-08

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 50.85  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRsgfaQLLS--LETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI--PSGIASIML 78
Cdd:cd17619     2 HILIVEDEPVTR----ATLKsyFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELreQSEVGIILV 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELI 109
Cdd:cd17619    78 TGRDDEVDRIVGLEIGADDYVTKPFNPRELL 108
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-117 2.26e-08

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 52.84  E-value: 2.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI----PSGIasI 76
Cdd:PRK00742    3 KIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKImrlrPTPV--V 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1376770573  77 MLS--VHDSPAMVEKSLELGAKGYLSKRCSP---------DELIQAVHTSAN 117
Cdd:PRK00742   81 MVSslTERGAEITLRALELGAVDFVTKPFLGislgmdeykEELAEKVRAAAR 132
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 3-114 4.52e-08

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 49.72  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDH----VIVRSGFAQLlSLETDITVV--GEfnsaaEA-----RLGLPSC--HPDVVILDISMQDESGLSLLEEI 69
Cdd:cd17557     1 TILLVEDNpgdaELIQEAFKEA-GVPNELHVVrdGE-----EAldflrGEGEYADapRPDLILLDLNMPRMDGFEVLREI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1376770573  70 PSG-----IASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHT 114
Cdd:cd17557    75 KADpdlrrIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRS 124
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-109 9.73e-08

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 48.46  E-value: 9.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETdiTVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI--PSGIASIMLSVH 81
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEMEG--FNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELrkTSQVPVLMLTAR 78

                          90       100
                  ....*....|....*....|....*...
gi 1376770573  82 DSPAMVEKSLELGAKGYLSKRCSPDELI 109
Cdd:cd17623    79 GDDIDRILGLELGADDYLPKPFNPRELV 106
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 6-101 1.02e-07

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 48.17  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQLLSLEtDITVVgEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI---PSGIASIMLSVHD 82
Cdd:cd17574     2 VVEDDEEIAELLSDYLEKE-GYEVD-TAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLrekGSDIPIIMLTAKD 79

                          90
                  ....*....|....*....
gi 1376770573  83 SPAMVEKSLELGAKGYLSK 101
Cdd:cd17574    80 EEEDKVLGLELGADDYITK 98
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 2-101 1.48e-07

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 47.99  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIAS-----I 76
Cdd:cd17561     2 IKVLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMRLEkrpkiI 81

                          90       100
                  ....*....|....*....|....*
gi 1376770573  77 MLSVHDSPAMVEKSLELGAKGYLSK 101
Cdd:cd17561    82 MLTAFGQEDITQRAVELGASYYILK 106
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 4-117 1.91e-07

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 47.79  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSlETDITVVGEFNSAAEArLGLPSCH-PDVVILDISMQDESGLSLLEEI----PSGIasIML 78
Cdd:cd19932     3 VLIAEDEALIRMDLREMLE-EAGYEVVGEASDGEEA-VELAKKHkPDLVIMDVKMPRLDGIEAAKIItsenIAPI--VLL 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHTSAN 117
Cdd:cd19932    79 TAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIA 117
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 2-112 3.13e-07

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 47.02  E-value: 3.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLEtDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDE-SGLSLLEEIPS--GIASIML 78
Cdd:cd17534     1 KKILIVEDEAIIALDLKEILESL-GYEVVGIADSGEEAIELAEENKPDLILMDINLKGDmDGIEAAREIREkfDIPVIFL 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17534    80 TAYSDEETLERAKETNPYGYLVKPFNERELKAAI 113
orf27 CHL00148
Ycf27; Reviewed
 6-108 3.59e-07

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 48.94  E-value: 3.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSgfaqllSLETDITVVG-EFNSAAEARLGLPSCH---PDVVILDISMQDESGLSLLEEI--PSGIASIMLS 79
Cdd:CHL00148   11 VVDDEAYIRK------ILETRLSIIGyEVITASDGEEALKLFRkeqPDLVILDVMMPKLDGYGVCQEIrkESDVPIIMLT 84

                          90       100
                  ....*....|....*....|....*....
gi 1376770573  80 VHDSPAMVEKSLELGAKGYLSKRCSPDEL 108
Cdd:CHL00148   85 ALGDVSDRITGLELGADDYVVKPFSPKEL 113
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 2-101 3.74e-07

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 49.02  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIAS-----I 76
Cdd:TIGR02875   3 IRIVIADDNKEFCNLLKEYLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEIELSarprvI 82

                          90       100
                  ....*....|....*....|....*
gi 1376770573  77 MLSVHDSPAMVEKSLELGAKGYLSK 101
Cdd:TIGR02875  83 MLSAFGQEKITQRAVALGADYYVLK 107
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
65-194 1.74e-06

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 46.24  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  65 LLEEIPSGIASIMLSVHDSPAMVEKSLELG--------AKGYLSKRCSP--DELIQAVH--TSANGGCYLTPDIAIKLAT 132
Cdd:COG2909    18 LLRHLPPNLHLVLASRTDPLARLRARLELRaddlrreeAAALLRRRLLPlsEEDAARLAerTEGWARLALDPEEALALLE 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376770573 133 PMKNKASLNQLTRRESEVCQ---------------LLATGLDVKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELA 194
Cdd:COG2909    98 RLLALAEAAGRLLLRALALRalgdreealaalrrrLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAV 174
PRK10430 PRK10430
two-component system response regulator DcuR;
1-101 1.86e-06

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 47.03  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIV----RSGFAQLlsleTDITVVGEFNSAAEAR--LGLPSCHPDVVILDISMQDESGLSLLEEIPSG-- 72
Cdd:PRK10430    1 MINVLIVDDDAMVaelnRRYVAQI----PGFQCCGTASTLEQAKeiIFNSDTPIDLILLDIYMQQENGLDLLPVLHEAgc 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1376770573  73 -IASIMLSVHDSPAMVEKSLELGAKGYLSK 101
Cdd:PRK10430   77 kSDVIVISSAADAATIKDSLHYGVVDYLIK 106
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 3-101 2.36e-06

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 44.74  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRSGFAQLLSLETDITVVGeFNSAAEArlgLPSC---HPDVVILDISMQDESGLSLLEEI---PSG--IA 74
Cdd:cd17551     2 RILIVDDNPTNLLLLEALLRSAGYLEVVS-FTDPREA---LAWCrenPPDLILLDYMMPGMDGLEFIRRLralPGLedVP 77

                          90       100
                  ....*....|....*....|....*..
gi 1376770573  75 SIMLSVHDSPAMVEKSLELGAKGYLSK 101
Cdd:cd17551    78 IVMITADTDREVRLRALEAGATDFLTK 104
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 7-113 2.45e-06

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 44.80  E-value: 2.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   7 VDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSchPDVVILDISMQDESGLSLLEEIP---SGIASIMLSVHDS 83
Cdd:cd17550     4 VDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERR--PDLVLLDIWLPDMDGLELLKEIKekyPDLPVIMISGHGT 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1376770573  84 PAMVEKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:cd17550    82 IETAVKATKLGAYDFIEKPLSLDRLLLTIE 111
PRK14084 PRK14084
DNA-binding response regulator;
2-113 3.96e-06

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 45.90  E-value: 3.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI-----PSGIasI 76
Cdd:PRK14084    1 MKALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIqkmkePPAI--I 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1376770573  77 MLSVHDSPAMveKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:PRK14084   79 FATAHDQFAV--KAFELNATDYILKPFEQKRIEQAVN 113
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 2-57 5.43e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.17  E-value: 5.43e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1376770573    2 INVALVDDHVIVRSGFAQLLSLETDitVVGEFNSAAEARLGLPSCHPDVVILDISM 57
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGY--EVDEATDGEEALELLKEEKPDLILLDIMM 54
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-109 1.75e-05

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 42.37  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGefNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIASI---MLSV 80
Cdd:cd17627     1 ILVVDDDRAVRESLRRSLRFEGYEVETA--VDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLpilVLTA 78

                          90       100
                  ....*....|....*....|....*....
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELI 109
Cdd:cd17627    79 RDSVSDRVAGLDAGADDYLVKPFALEELL 107
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-112 2.72e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 41.69  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLL-SLETDITVVgefNSAAEA--RLGlpSCHPDVVILDISMQDESGLSLLEEI---PSGIAS-- 75
Cdd:cd17546     1 VLVVDDNPVNRKVLKKLLeKLGYEVDVA---ENGQEAleLLK--EEPFDLVLMDLQMPVMDGLEATRRIrelEGGGRRtp 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1376770573  76 -IMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17546    76 iIALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 2-113 3.30e-05

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 41.62  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLEtDITVVgEFNSAAEArLGLPSCHP-DVVILDISMQDESGLSLLEEI----PSgIASI 76
Cdd:cd17569     1 PTILLVDDEPNILKALKRLLRRE-GYEVL-TATSGEEA-LEILKQEPvDVVISDQRMPGMDGAELLKRVreryPD-TVRI 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1376770573  77 MLSVH-DSPAMVEKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:cd17569    77 LLTGYaDLDAAIEAINEGEIYRFLTKPWDDEELKETIR 114
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 33-101 3.50e-05

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 41.49  E-value: 3.50e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376770573  33 FNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIP---SGIASIMLSVH-DSPAMVeKSLELGAKGYLSK 101
Cdd:cd19919    30 FENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKqrhPDLPVIIMTAHsDLDSAV-SAYQGGAFEYLPK 101
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 4-101 3.55e-05

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 41.28  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAqlLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI--PSGIASIMLSVH 81
Cdd:cd19936     1 IALVDDDRNILTSVS--MALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLrqKSTLPVIFLTSK 78

                          90       100
                  ....*....|....*....|
gi 1376770573  82 DSPAMVEKSLELGAKGYLSK 101
Cdd:cd19936    79 DDEIDEVFGLRMGADDYITK 98
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-101 3.59e-05

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 41.66  E-value: 3.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGEfnSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI--PSGIASIMLSVH 81
Cdd:cd17594     2 VLVVDDDAAMRHLLILYLRERGFDVTAAA--DGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIraRSDVPIIIISGD 79

                          90       100
                  ....*....|....*....|.
gi 1376770573  82 -DSPAMVEKSLELGAKGYLSK 101
Cdd:cd17594    80 rRDEIDRVVGLELGADDYLAK 100
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 6-110 3.90e-05

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 41.48  E-value: 3.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQLLsLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQD-ESGLSLLEE------IPSGIASIML 78
Cdd:cd17589     3 IVDDQPTFRSMLKSML-RSLGVTRIDTASSGEEALRMCENKTYDIVLCDYNLGKgKNGQQLLEElrhkklISPSTVFIMV 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELIQ 110
Cdd:cd17589    82 TGESSRAMVLSALELEPDDYLLKPFTVSELRE 113
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 49-112 4.25e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 41.52  E-value: 4.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1376770573  49 DVVILDISMQDESGLSLLEEI---PS--GIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17562    46 DLIITDQNMPNMDGIELIKELrklPAykFTPILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVV 114
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 4-109 7.20e-05

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 40.82  E-value: 7.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLL-SLETDITVVGEFNSAAEArlgLPSCHPDVVILDISMQDESGLSLLEEIPSGIAS--IMLSV 80
Cdd:cd17622     3 ILLVEDDPKLARLIADFLeSHGFNVVVEHRGDRALEV---IAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGpiLLLTA 79

                          90       100
                  ....*....|....*....|....*....
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDELI 109
Cdd:cd17622    80 LDSDIDHILGLELGADDYVVKPVEPAVLL 108
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 8-101 1.09e-04

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 39.84  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   8 DDHVIVRsgFAQLlSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIP--SGIASIMLSVHDSPA 85
Cdd:cd17620     6 DEPQIRR--FLRT-ALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLRewSAVPVIVLSARDEES 82

                          90
                  ....*....|....*.
gi 1376770573  86 MVEKSLELGAKGYLSK 101
Cdd:cd17620    83 DKIAALDAGADDYLTK 98
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 2-113 1.25e-04

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 40.21  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNsAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIP-SGIAS--IML 78
Cdd:cd17593     1 MKVLICDDSSMARKQLARALPADWDVEITFAEN-GEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPvEQLETkvIVV 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:cd17593    80 SGDVQPEAKERVLELGALAFLKKPFDPEKLAQLLE 114
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 6-101 1.28e-04

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 39.56  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIAS---IMLSVHD 82
Cdd:cd17565     3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNgkfIMISQVS 82

                          90
                  ....*....|....*....
gi 1376770573  83 SPAMVEKSLELGAKGYLSK 101
Cdd:cd17565    83 DKEMIGKAYQAGIEFFINK 101
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 2-109 1.34e-04

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 40.08  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITvvgeFNSAA---EARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIAS--- 75
Cdd:cd17575     1 IMVLLVDDQAIIGEAVRRALADEEDID----FHYCSdptEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANPATrdi 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1376770573  76 --IMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELI 109
Cdd:cd17575    77 piIVLSTKEEPEVKSEAFALGANDYLVKLPDKIELV 112
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 3-112 1.39e-04

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 39.93  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRSGFAqlLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLL-----EEIPSGIASIM 77
Cdd:cd17618     2 TILIVEDEPAIREMIA--FNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIrrlkrDEMTRDIPIIM 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1376770573  78 LSVHDSPAMVEKSLELGAKGYLSKRCSPDEL---IQAV 112
Cdd:cd17618    80 LTARGEEEDKVRGLEAGADDYITKPFSPRELvarIKAV 117
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
4-108 1.57e-04

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 41.76  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLETDITVVGefNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPS---GIASIMLSV 80
Cdd:PRK11361    7 ILIVDDEDNVRRMLSTAFALQGFETHCA--NNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRShetRTPVILMTA 84

                          90       100
                  ....*....|....*....|....*...
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDEL 108
Cdd:PRK11361   85 YAEVETAVEALRCGAFDYVIKPFDLDEL 112
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 4-112 2.26e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 39.66  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVivRSGFAQLLSLETDITVVGEfNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI----PSGIASIMLS 79
Cdd:cd17596     3 ILVVDDEV--RSLEALRRTLEEDFDVLTA-ASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVrerwPEVVRIIISG 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1376770573  80 VHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17596    80 YTDSEDIIAGINEAGIYQYLTKPWHPDQLLLTV 112
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 7-101 2.62e-04

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 39.11  E-value: 2.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   7 VDDHVIVRSGFAQLLSlETDITVVgefnSAAEARLGLPSC---HPDVVILDISMQDESGLSLLEEIP---SGIASIMLSV 80
Cdd:cd17555     6 IDDDEVVRESIAAYLE-DSGFQVL----QAADGRQGLELFrseQPDLVLCDLRMPEMDGLEVLKQITkesPDTPVIVVSG 80

                          90       100
                  ....*....|....*....|.
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSK 101
Cdd:cd17555    81 AGVMSDAVEALRLGAWDYLTK 101
PRK10766 PRK10766
two-component system response regulator TorR;
3-109 3.16e-04

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 40.02  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRSGFAQLLSLETdiTVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI--PSGIASIMLSV 80
Cdd:PRK10766    4 HILVVEDEPVTRARLQGYFEQEG--YTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELrsRSTVGIILVTG 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1376770573  81 HDSPamVEK--SLELGAKGYLSKRCSPDELI 109
Cdd:PRK10766   82 RTDS--IDRivGLEMGADDYVTKPLELRELL 110
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 36-112 3.37e-04

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 38.68  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  36 AAEARLGLPSCH---PDVVILDISMQDESGLS---LLEEIP--SGIASIMLSVHdspAMV---EKSLELGAKGYLSKRCS 104
Cdd:cd17548    29 AADGEEALEIARkekPDLILMDIQLPGMDGLEatrLLKEDPatRDIPVIALTAY---AMKgdrEKILEAGCDGYISKPID 105


                  ....*...
gi 1376770573 105 PDELIQAV 112
Cdd:cd17548   106 TREFLETV 113
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 1-101 5.86e-04

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 39.40  E-value: 5.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSgFAQLlSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIP--SGIASIML 78
Cdd:PRK10529    1 MTNVLIVEDEQAIRR-FLRT-ALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRqwSAIPVIVL 78

                          90       100
                  ....*....|....*....|...
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSK 101
Cdd:PRK10529   79 SARSEESDKIAALDAGADDYLSK 101
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 47-101 6.58e-04

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 37.76  E-value: 6.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  47 HPDVVILDISMQDESGLSLLEEIPS-----GIASIMLSVHDSPAMVEKSLELGAKGYLSK 101
Cdd:cd17582    44 EIDLILTEVDLPVSSGFKLLSYIMRhkickNIPVIMMSSQDSVGVVFKCLSKGAADYLVK 103
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 49-109 6.94e-04

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 37.97  E-value: 6.94e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1376770573  49 DVVILDISMQDESGLSLLEEI-PSGIAS--IMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELI 109
Cdd:cd17625    43 DLIILDIMLPGMDGLEVLKSLrEEGIETpvLLLTALDAVEDRVKGLDLGADDYLPKPFSLAELL 106
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 48-114 7.32e-04

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 37.74  E-value: 7.32e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1376770573  48 PDVVILDISMQDESGLSLLEEIP--SGIASIMLSvhdspAMVEK-----SLELGAKGYLSKRCSPDELIQAVHT 114
Cdd:cd19938    44 PDLILLDLMLPGTDGLTLCREIRrfSDVPIIMVT-----ARVEEidrllGLELGADDYICKPYSPREVVARVKA 112
pleD PRK09581
response regulator PleD; Reviewed
 3-114 7.35e-04

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 39.50  E-value: 7.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRSGFAQLLSLETDITVVGefnSAAEARLGLPSCHPDVVILDISMQDESGLSL------LEEIpSGIASI 76
Cdd:PRK09581  157 RILLVDDDVSQAERIANILKEEFRVVVVS---DPSEALFNAAETNYDLVIVSANFENYDPLRLcsqlrsKERT-RYVPIL 232

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1376770573  77 MLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHT 114
Cdd:PRK09581  233 LLVDEDDDPRLVKALELGVNDYLMRPIDKNELLARVRT 270
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 48-112 7.58e-04

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 37.64  E-value: 7.58e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  48 PDVVILDISMQDESGLSLLEEI-----PSGIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd19937    42 PDLIILDLMLPGIDGLEVCRILrsdpkTSSIPIIMLTAKGEEFDKVLGLELGADDYITKPFSPRELLARV 111
ompR PRK09468
osmolarity response regulator; Provisional
 4-112 7.96e-04

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 39.19  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSlETDITVVGEFNSAAEARLgLPSCHPDVVILDISMQDESGLSL---LEEIPSGIASIMLSV 80
Cdd:PRK09468    8 ILVVDDDMRLRALLERYLT-EQGFQVRSAANAEQMDRL-LTRESFHLMVLDLMLPGEDGLSIcrrLRSQNNPTPIIMLTA 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1376770573  81 HDSPAMVEKSLELGAKGYLSKRCSPDEL---IQAV 112
Cdd:PRK09468   86 KGEEVDRIVGLEIGADDYLPKPFNPRELlarIRAV 120
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-112 9.17e-04

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 37.56  E-value: 9.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   4 VALVDDHVIVRSGFAQLLSLET-DITVVgefNSAAEARLGLPSCHPDVVILDISMQDESGLSLLE-----EIPSGIasIM 77
Cdd:cd17572     1 VLLVEDSPSLAALYQEYLSDEGyKVTHV---ETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKwiqerSLPTSV--IV 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1376770573  78 LSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17572    76 ITAHGSVDIAVEAMRLGAYDFLEKPFDADRLRVTV 110
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
 137-185 9.29e-04

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 38.10  E-value: 9.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1376770573 137 KASLNQLTRRESEVCQLLAT-GLDVKSIAVELGVSHKTVHVHRANAMDKL 185
Cdd:TIGR02937 105 REALEKLPEREREVLVLRYLeGLSYKEIAEILGISVGTVKRRLKRARKKL 154
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 48-112 9.49e-04

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 37.40  E-value: 9.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376770573  48 PDVVILDISMQDESGLSLLEEI--PSGIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17614    43 PDLILLDLMLPEKDGLEVCREVrkTSNVPIIMLTAKDSEVDKVLGLELGADDYVTKPFSNRELLARV 109
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 48-112 1.15e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 37.53  E-value: 1.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  48 PDVVILDISMQDESGLSLLEEIPS-----GIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17552    47 PDAILLDVMMPDMDGLATLKKLQAnpetqSIPVILLTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQI 116
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 48-114 1.21e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 37.45  E-value: 1.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1376770573  48 PDVVILDISMQDESGLSLLEEI--PSGIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVHT 114
Cdd:cd17626    45 PDLVLLDLMLPGIDGIEVCRQIraESGVPIVMLTAKSDTVDVVLGLESGADDYVAKPFKPKELVARIRA 113
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 49-101 1.25e-03

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 37.03  E-value: 1.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1376770573  49 DVVILDISMQDESGLSLLEEI-PSGIAS--IMLSVHDSpamVE---KSLELGAKGYLSK 101
Cdd:cd19935    44 DLIILDVMLPGLDGLEVLRRLrAAGKQTpvLMLTARDS---VEdrvKGLDLGADDYLVK 99
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
2-69 1.31e-03

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 38.71  E-value: 1.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376770573   2 INVALVDDHVIVRSGFAQLLSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI 69
Cdd:PRK12555    1 MRIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRI 68
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 97-193 1.65e-03

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 38.19  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  97 GYLSKRCSPDELIQAVHTSANGgcyltpdiAIKLATPMKNKASLNQ---LTRRESEVCQLLATGLDVKSIAVELGVSHKT 173
Cdd:PRK11475   94 GVLSKASTLEILQQELFLSLNG--------VRQATDRLNNQWYINQsrmLSPTEREILRFMSRGYSMPQIAEQLERNIKT 165

                          90       100
                  ....*....|....*....|
gi 1376770573 174 VHVHRANAMDKLNVKNNVEL 193
Cdd:PRK11475  166 IRAHKFNVMSKLGVSSDAGL 185
PRK10188 PRK10188
transcriptional regulator SdiA;
95-194 2.45e-03

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 37.84  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  95 AKGYLSKRCspdeliqavhTSANGGCYLTPDIAIKLAtpMKNKASLNQLTR---------------RESEVCQLLATGLD 159
Cdd:PRK10188  129 ALGFLSFSR----------CSAREIPILSDELELRLQ--LLVRESLMALMRledemvmtpemnfskREKEILKWTAEGKT 196

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1376770573 160 VKSIAVELGVSHKTVHVHRANAMDKLNVKNNVELA 194
Cdd:PRK10188  197 SAEIAMILSISENTVNFHQKNMQKKFNAPNKTQIA 231
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-109 2.79e-03

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 37.47  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   1 MINVALVDDHVIVRSGFAQLLSLETDITVVGEfnsAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPSGIAS--IML 78
Cdd:PRK10955    1 MNKILLVDDDRELTSLLKELLEMEGFNVIVAH---DGEQALDLLDDSIDLLLLDVMMPKKNGIDTLKELRQTHQTpvIML 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1376770573  79 SVHDSPAMVEKSLELGAKGYLSKRCSPDELI 109
Cdd:PRK10955   78 TARGSELDRVLGLELGADDYLPKPFNDRELV 108
PRK10643 PRK10643
two-component system response regulator PmrA;
6-108 2.90e-03

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 37.32  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   6 LVDDHVIVRSGFAQllSLETDITVVGEFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEIPS---GIASIMLSVHD 82
Cdd:PRK10643    5 IVEDDTLLLQGLIL--ALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQkkyTLPVLILTARD 82

                          90       100
                  ....*....|....*....|....*.
gi 1376770573  83 SPAMVEKSLELGAKGYLSKRCSPDEL 108
Cdd:PRK10643   83 TLEDRVAGLDVGADDYLVKPFALEEL 108
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 47-133 3.02e-03

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 37.36  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573  47 HPDVVILDISMQDESGLSLLEEIP--SGIASIMLSvhdspAMVEK-----SLELGAKGYLSKRCSPDELIQAVHTSANgG 119
Cdd:PRK10710   54 PPDLILLDLMLPGTDGLTLCREIRrfSDIPIVMVT-----AKIEEidrllGLEIGADDYICKPYSPREVVARVKTILR-R 127

                          90
                  ....*....|....
gi 1376770573 120 CYLTPDIAIKLATP 133
Cdd:PRK10710  128 CKPQRELQQQDAES 141
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 7-69 3.05e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 36.04  E-value: 3.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1376770573   7 VDDHVIVRSGFAQLLSLET-DITVVGefnSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI 69
Cdd:cd17554     6 VDDEENIRELYKEELEDEGyEVVTAG---NGEEALEKLESEDPDLVILDIKMPGMDGLETLRKI 66
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 3-113 4.29e-03

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 37.16  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376770573   3 NVALVDDHVIVRsgfaqlLSLETDITVVG----EFNSAAEARLGLPSCHPDVVILDISMQDESGLSLLEEI----PSGIA 74
Cdd:PRK10923    5 IVWVVDDDSSIR------WVLERALAGAGltctTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIkqrhPMLPV 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1376770573  75 SIMLSVHDSPAMVeKSLELGAKGYLSKRCSPDELIQAVH 113
Cdd:PRK10923   79 IIMTAHSDLDAAV-SAYQQGAFDYLPKPFDIDEAVALVE 116
PRK10693 PRK10693
two-component system response regulator RssB;
38-101 5.08e-03

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 36.89  E-value: 5.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376770573  38 EARLGLPSCHPDVVILDISMQDESGLSLLEEIPS---GIASIMLSVHDSPAMVEKSLELGAKGYLSK 101
Cdd:PRK10693    8 DALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNrgdQTPVLVISATENMADIAKALRLGVQDVLLK 74
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 48-112 5.42e-03

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 35.61  E-value: 5.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376770573  48 PDVVILDISMQDESGLSLL---EEIPSGIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAV 112
Cdd:cd17553    45 PDLVLLDMKIPGMDGIEILkrmKVIDENIRVIIMTAYGELDMIQESKELGALTHFAKPFDIDEIRDAV 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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