trimethylamine-N-oxide reductase c-type cytochrome TorC; This family includes consists of TorC, ...
7-393
0e+00
trimethylamine-N-oxide reductase c-type cytochrome TorC; This family includes consists of TorC, a pentahemic c-type cytochrome subunit of periplasmic reductases for trimethylamine-N-oxide (TMAO). The N-terminal half is closely related to tetrahemic NapC (or NirT) subunits of periplasmic nitrate (or nitrite) reductases; some species have both TMAO and nitrate reductase complexes.
The actual alignment was detected with superfamily member TIGR02162:
Pssm-ID: 274003 Cd Length: 386 Bit Score: 592.63 E-value: 0e+00
trimethylamine-N-oxide reductase c-type cytochrome TorC; This family includes consists of TorC, ...
7-393
0e+00
trimethylamine-N-oxide reductase c-type cytochrome TorC; This family includes consists of TorC, a pentahemic c-type cytochrome subunit of periplasmic reductases for trimethylamine-N-oxide (TMAO). The N-terminal half is closely related to tetrahemic NapC (or NirT) subunits of periplasmic nitrate (or nitrite) reductases; some species have both TMAO and nitrate reductase complexes.
Pssm-ID: 274003 Cd Length: 386 Bit Score: 592.63 E-value: 0e+00
NapC/NirT cytochrome c family, N-terminal region; Within the NapC/NirT family of cytochrome c ...
14-189
1.56e-111
NapC/NirT cytochrome c family, N-terminal region; Within the NapC/NirT family of cytochrome c proteins, some members, such as NapC and NirT, bind four haem groups, while others, such as TorC, bind five haems. This family aligns the common N-terminal region that contains four haem-binding C-X(2)-CH motifs.
Pssm-ID: 427224 Cd Length: 174 Bit Score: 323.43 E-value: 1.56e-111
sulfate reduction electron transfer complex DsrMKJOP subunit DsrJ; Proteins of this family are ...
40-86
2.03e-04
sulfate reduction electron transfer complex DsrMKJOP subunit DsrJ; Proteins of this family are the DsrJ subunit of the DsrMKJOP complex, which is a membrane-bound redox complex involved in sulfate reduction in Sulfate-reducing organisms (SROs). The dsrJ gene encodes a triheme periplasmic cytochrome c subunit, which contains three conserved heme c-binding sites (CXXCH) at the C terminal.
Pssm-ID: 468322 Cd Length: 119 Bit Score: 40.62 E-value: 2.03e-04
trimethylamine-N-oxide reductase c-type cytochrome TorC; This family includes consists of TorC, ...
7-393
0e+00
trimethylamine-N-oxide reductase c-type cytochrome TorC; This family includes consists of TorC, a pentahemic c-type cytochrome subunit of periplasmic reductases for trimethylamine-N-oxide (TMAO). The N-terminal half is closely related to tetrahemic NapC (or NirT) subunits of periplasmic nitrate (or nitrite) reductases; some species have both TMAO and nitrate reductase complexes.
Pssm-ID: 274003 Cd Length: 386 Bit Score: 592.63 E-value: 0e+00
NapC/NirT cytochrome c family, N-terminal region; Within the NapC/NirT family of cytochrome c ...
14-189
1.56e-111
NapC/NirT cytochrome c family, N-terminal region; Within the NapC/NirT family of cytochrome c proteins, some members, such as NapC and NirT, bind four haem groups, while others, such as TorC, bind five haems. This family aligns the common N-terminal region that contains four haem-binding C-X(2)-CH motifs.
Pssm-ID: 427224 Cd Length: 174 Bit Score: 323.43 E-value: 1.56e-111
periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Nearly every member of this subfamily is NapC, a predicted membrane-anchored four-heme c-type cytochrome that forms one component of the periplasmic nitrate reductase along with NapA, NapB, NapD, NapE, and NapF subunits. A single known exception at this time is NirT, which is instead a component of a nitrite reductase. This family excludes TorC subunits of trimethylamine N-oxide (TMAO) reductases.
Pssm-ID: 131216 Cd Length: 185 Bit Score: 308.62 E-value: 1.61e-105
cytochrome c nitrite reductase, small subunit; Members of this protein family are NrfH, a ...
19-183
9.67e-15
cytochrome c nitrite reductase, small subunit; Members of this protein family are NrfH, a tetraheme cytochrome c. NrfH is the cytochrome c nitrite reductase small subunit, and forms a heterodimer with NrfA, the catalytic subunit. While NrfA can act as a monomer, NrfH can bind to and anchor NrfA in the membrane and enables electron transfer to NrfA from quinones. [Energy metabolism, Electron transport]
Pssm-ID: 274453 [Multi-domain] Cd Length: 135 Bit Score: 70.45 E-value: 9.67e-15
sulfate reduction electron transfer complex DsrMKJOP subunit DsrJ; Proteins of this family are ...
40-86
2.03e-04
sulfate reduction electron transfer complex DsrMKJOP subunit DsrJ; Proteins of this family are the DsrJ subunit of the DsrMKJOP complex, which is a membrane-bound redox complex involved in sulfate reduction in Sulfate-reducing organisms (SROs). The dsrJ gene encodes a triheme periplasmic cytochrome c subunit, which contains three conserved heme c-binding sites (CXXCH) at the C terminal.
Pssm-ID: 468322 Cd Length: 119 Bit Score: 40.62 E-value: 2.03e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
Click on the triangle to view details about the feature, including a multiple sequence alignment
of your query sequence and the protein sequences used to curate the domain model,
where hash marks (#) above the aligned sequences show the location of the conserved feature residues.
The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
Click on the triangle for interactive 3D structure viewing options.
Functional characterization of the conserved domain architecture found on the query.
Click here to see more details.
This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
(labeled illustration) or all hits
(labeled illustration).
Domains are color coded according to superfamilies
to which they have been assigned. Hits with scores that pass a domain-specific threshold
(specific hits) are drawn in bright colors.
Others (non-specific hits) and
superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
with the same color and shade of the domain or superfamily that provides the annotation. Mouse over the colored bars or triangles to see descriptions of the domains and features.
click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
mapped to the query sequence.
Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
(CDART).
Modify your query to search against a different database and/or use advanced search options
