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Conserved domains on  [gi|1377813779|gb|PTV75272|]
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GntR family transcriptional regulator [Agrobacterium pusense]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-213 2.69e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.48  E-value: 2.69e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779   1 MPKTAKNSPEdTIAARISRTLADRIVRGELSPGERLRQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVADFGL 80
Cdd:COG1802     1 MTSPSPLRRE-SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  81 DDVREVAEMRAALEVLALRHAIPNMTSAILDQAEAATLEGDSAV---DVEHWEEANRRFHRLITAPCNMPRLMEAIDGLH 157
Cdd:COG1802    80 EEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAaagDVAAYLELDREFHRALVEAAGNPRLAELLRRLR 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1377813779 158 AASARFLFSAWR-AGWERRTDTDHRAIIDALRGGRAEEAVRILDGHVQWIGRKAIRT 213
Cdd:COG1802   160 ARLRRYRRLSLRsPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEA 216
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-213 2.69e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.48  E-value: 2.69e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779   1 MPKTAKNSPEdTIAARISRTLADRIVRGELSPGERLRQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVADFGL 80
Cdd:COG1802     1 MTSPSPLRRE-SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  81 DDVREVAEMRAALEVLALRHAIPNMTSAILDQAEAATLEGDSAV---DVEHWEEANRRFHRLITAPCNMPRLMEAIDGLH 157
Cdd:COG1802    80 EEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAaagDVAAYLELDREFHRALVEAAGNPRLAELLRRLR 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1377813779 158 AASARFLFSAWR-AGWERRTDTDHRAIIDALRGGRAEEAVRILDGHVQWIGRKAIRT 213
Cdd:COG1802   160 ARLRRYRRLSLRsPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEA 216
PRK11414 PRK11414
GntR family transcriptional regulator;
1-193 4.80e-17

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 76.83  E-value: 4.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779   1 MPKTAKnSPEDTIAARISRTLADRIVRGELSPGERLRQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVADFGL 80
Cdd:PRK11414    1 MPGTEK-TQHISLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  81 DDVREVAEMRAALEVLALRHAIPNMT-------SAILDQAEAATLEGdsavDVEHWEEANRRFHRLITAPCNMPRLMEAI 153
Cdd:PRK11414   80 RQLDEINRIRYELELMAVALAVENLTpqdlaelQELLEKLQQAQEKG----DMEQIINANRLFRLAIYHRSNMPILCEMI 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1377813779 154 DGL---HAASARFLFSAWRAGWERRTDTDHRAIIDALRGGRAE 193
Cdd:PRK11414  156 EQLwvrMGPSLHYLYEAINPAELREHIENYRLLLAALKAKDKE 198
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 85-199 2.97e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 72.02  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  85 EVAEMRAALEVLALRHAIPNMTSAILDQAEAATLEGDSAV---DVEHWEEANRRFHRLITAPCNMPRLMEAIDGLHAASA 161
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAAdagDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1377813779 162 RFLFSAWR-AGWERRTDTDHRAIIDALRGGRAEEAVRIL 199
Cdd:pfam07729  81 RLRRLLLSsPGRLRASLEEHRAILDAIRARDPEAARAAM 119
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 85-204 4.94e-16

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 71.62  E-value: 4.94e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779   85 EVAEMRAALEVLALRHAIPNMTSAILDQAEAATLEGDSAV----DVEHWEEANRRFHRLITAPCNMPRLMEAIDGLHAAS 160
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAaagdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1377813779  161 ARFLFSawRAGWERRTDTDHRAIIDALRGGRAEEAVRILDGHVQ 204
Cdd:smart00895  81 RRLRRL--SLEAARRALDEHRAILDAIRARDAEAARAAMREHLE 122
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-76 1.35e-14

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 65.93  E-value: 1.35e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1377813779  12 TIAARISRTLADRIVRGELSPGERLR-QDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVA 76
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-213 2.69e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.48  E-value: 2.69e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779   1 MPKTAKNSPEdTIAARISRTLADRIVRGELSPGERLRQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVADFGL 80
Cdd:COG1802     1 MTSPSPLRRE-SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  81 DDVREVAEMRAALEVLALRHAIPNMTSAILDQAEAATLEGDSAV---DVEHWEEANRRFHRLITAPCNMPRLMEAIDGLH 157
Cdd:COG1802    80 EEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAaagDVAAYLELDREFHRALVEAAGNPRLAELLRRLR 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1377813779 158 AASARFLFSAWR-AGWERRTDTDHRAIIDALRGGRAEEAVRILDGHVQWIGRKAIRT 213
Cdd:COG1802   160 ARLRRYRRLSLRsPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEA 216
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
12-208 2.45e-26

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 101.55  E-value: 2.45e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  12 TIAARISRTLADRIVRGELSPGERL---RQdhIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVAD----------- 77
Cdd:COG2186     7 SLAEQVAEQLRELILSGELKPGDRLpseRE--LAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREpspwalldpla 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  78 ----FGLDDVREVAEMRAALEVLALRHAIPNMTSAILDQAEAATLEGDSAV-DVEHWEEANRRFHRLITAPCNMPRLMEA 152
Cdd:COG2186    85 lllaLDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAAdDGEAFAEADLAFHRAIAEASGNPLLALL 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1377813779 153 IDGLHAA-SARFLFSAWRAGWERRTDTDHRAIIDALRGGRAEEAVRILDGHVQWIGR 208
Cdd:COG2186   165 LESLRELlRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRE 221
PRK11414 PRK11414
GntR family transcriptional regulator;
1-193 4.80e-17

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 76.83  E-value: 4.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779   1 MPKTAKnSPEDTIAARISRTLADRIVRGELSPGERLRQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVADFGL 80
Cdd:PRK11414    1 MPGTEK-TQHISLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  81 DDVREVAEMRAALEVLALRHAIPNMT-------SAILDQAEAATLEGdsavDVEHWEEANRRFHRLITAPCNMPRLMEAI 153
Cdd:PRK11414   80 RQLDEINRIRYELELMAVALAVENLTpqdlaelQELLEKLQQAQEKG----DMEQIINANRLFRLAIYHRSNMPILCEMI 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1377813779 154 DGL---HAASARFLFSAWRAGWERRTDTDHRAIIDALRGGRAE 193
Cdd:PRK11414  156 EQLwvrMGPSLHYLYEAINPAELREHIENYRLLLAALKAKDKE 198
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 85-199 2.97e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 72.02  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  85 EVAEMRAALEVLALRHAIPNMTSAILDQAEAATLEGDSAV---DVEHWEEANRRFHRLITAPCNMPRLMEAIDGLHAASA 161
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAAdagDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1377813779 162 RFLFSAWR-AGWERRTDTDHRAIIDALRGGRAEEAVRIL 199
Cdd:pfam07729  81 RLRRLLLSsPGRLRASLEEHRAILDAIRARDPEAARAAM 119
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 85-204 4.94e-16

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 71.62  E-value: 4.94e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779   85 EVAEMRAALEVLALRHAIPNMTSAILDQAEAATLEGDSAV----DVEHWEEANRRFHRLITAPCNMPRLMEAIDGLHAAS 160
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAaagdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1377813779  161 ARFLFSawRAGWERRTDTDHRAIIDALRGGRAEEAVRILDGHVQ 204
Cdd:smart00895  81 RRLRRL--SLEAARRALDEHRAILDAIRARDAEAARAAMREHLE 122
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-76 1.35e-14

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 65.93  E-value: 1.35e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1377813779  12 TIAARISRTLADRIVRGELSPGERLR-QDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVA 76
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 19-203 3.22e-14

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 69.15  E-value: 3.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  19 RTLADRIVRGELSPGERLRQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVADFGLDDVREVAEMRAALEVLAL 98
Cdd:PRK11534   14 RWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  99 RHAIP----NMTSAILdqAEAATLEGDSAVD-----VEHWEEANRRFHRLITAPCNMPRLMEAIDGLHAASARFLFSawr 169
Cdd:PRK11534   94 SLAIArggdEWEADVL--AKAHLLSKLEACDasekmLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYRFI--- 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1377813779 170 agWERRT----------DTDHRAIIDALRGGRAEEAVRILDGHV 203
Cdd:PRK11534  169 --WLRRTvlsvemledkHDQHQTLTAAILARDTARASELMRQHL 210
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 14-75 8.05e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.78  E-value: 8.05e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1377813779  14 AARISRTLADRIVRGELSPGERL-RQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRV 75
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
21-75 1.65e-09

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 52.19  E-value: 1.65e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1377813779   21 LADRIVRGELSPGERLR-QDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRV 75
Cdd:smart00345   5 LREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 12-109 1.32e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 54.45  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  12 TIAARISRTLADRIVRGELSPGERL---RQdhIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVADfGLDDVREVAE 88
Cdd:COG1167    12 PLYLQLADALREAILSGRLPPGDRLpssRE--LAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA-RLPAPAPAPR 88

                          90       100
                  ....*....|....*....|.
gi 1377813779  89 MRAALEVLALRHAIPNMTSAI 109
Cdd:COG1167    89 AAAAVAAPALRRLLEAAPGVI 109
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
16-77 1.05e-07

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 51.02  E-value: 1.05e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1377813779  16 RISRTLADRIVRGELSPGERL-RQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVAD 77
Cdd:COG2188     9 QIADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE 71
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
17-97 5.26e-07

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 46.71  E-value: 5.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  17 ISRTLADRIVRGELSPGERL---RQdhIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRVADfGLDDVREVAEMRAAL 93
Cdd:COG1725    15 IADQIKEAIASGELKPGDRLpsvRE--LAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE-DARELLEERREEFLE 91


                  ....
gi 1377813779  94 EVLA 97
Cdd:COG1725    92 EALR 95
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 21-204 5.96e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 42.70  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  21 LADRIVRGELSPGERLRQDH-IAAEFGASHVPVREAFRRLEAQGL---------------AASIPRRGVRVADFGL---- 80
Cdd:PRK03837   22 LEQMIRSGEFGPGDQLPSEReLMAFFGVGRPAVREALQALKRKGLvqishgerarvsrpsADTIIGQLSGMAKDFLsqsp 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377813779  81 DDVREVAEMRAALEVLALRHAIPNMTSA-ILDQAEAATLEGDSAVDVEHWEEANRRFHRLITAPCNMPRLMEAIDGLHA- 158
Cdd:PRK03837  102 DGLAHLKQARLFFESSLARYAAEHATDEqIALLRKALERNSQSLGDNAAFIRSDMEFHRVIAEIPGNPIFMAIHEALLDw 181

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1377813779 159 -ASARFLFSAWRaGWERRTDTDHRAIIDALRGGRAEEAVRILDGHVQ 204
Cdd:PRK03837  182 lIEARPEVVILH-GHENVTLQEHIAIVDAIRAHDPDEADRALQSHLN 227
PRK09764 PRK09764
GntR family transcriptional regulator;
16-75 4.84e-04

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 40.20  E-value: 4.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1377813779  16 RISRTLADRIVRGELSPGERL-RQDHIAAEFGASHVPVREAFRRLEAQGLAASIPRRGVRV 75
Cdd:PRK09764    9 QIADRIREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
11-64 1.55e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 38.46  E-value: 1.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1377813779  11 DTIAARISRTladrIVRGELSPGERL---RQdhIAAEFGASHVPVREAFRRLEAQGL 64
Cdd:PRK09464   13 DVIEQQLEFL----ILEGTLRPGEKLppeRE--LAKQFDVSRPSLREAIQRLEAKGL 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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