NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1379292836|gb|PUD09919|]
View 

outer membrane beta-barrel protein, partial [Helicobacter pylori]

Protein Classification

porin family protein( domain architecture ID 229388)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
OM_channels super family cl21487
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
1-39 3.98e-03

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


The actual alignment was detected with superfamily member pfam01856:

Pssm-ID: 473880  Cd Length: 154  Bit Score: 31.86  E-value: 3.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379292836   1 GLKIPLAVNSFYethgKGLNTSLFFKRLVVFNVSYVYSF 39
Cdd:pfam01856 120 GVKIPTINNNYY----KTLGYTLDFRRLYSFYVNYTYNF 154
 
Name Accession Description Interval E-value
HP_OMP pfam01856
Helicobacter outer membrane protein; This family seems confined to Helicobacter. It is ...
1-39 3.98e-03

Helicobacter outer membrane protein; This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins.


Pssm-ID: 280099  Cd Length: 154  Bit Score: 31.86  E-value: 3.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379292836   1 GLKIPLAVNSFYethgKGLNTSLFFKRLVVFNVSYVYSF 39
Cdd:pfam01856 120 GVKIPTINNNYY----KTLGYTLDFRRLYSFYVNYTYNF 154
 
Name Accession Description Interval E-value
HP_OMP pfam01856
Helicobacter outer membrane protein; This family seems confined to Helicobacter. It is ...
1-39 3.98e-03

Helicobacter outer membrane protein; This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins.


Pssm-ID: 280099  Cd Length: 154  Bit Score: 31.86  E-value: 3.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379292836   1 GLKIPLAVNSFYethgKGLNTSLFFKRLVVFNVSYVYSF 39
Cdd:pfam01856 120 GVKIPTINNNYY----KTLGYTLDFRRLYSFYVNYTYNF 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH