|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
7-1298 |
0e+00 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 2904.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 7 LTLQVLQQRLDALMLRDKQRFARRLHGVKKVKNPDAQQAIFQTMAKEIEQAAAQVALREAARPSITYPQNLPVSQKKQDI 86
Cdd:PRK11131 3 LTLTALQQQLDELMLRDRQRLSRRLHGAKKIKNPDAQQAIFQEIAKEIAQAAQRVLLREAARPEITYPENLPVSQKKQDI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 87 LEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGYKVRFSDHVSS 166
Cdd:PRK11131 83 LEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 167 NTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPI 246
Cdd:PRK11131 163 NTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 247 IEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELGRESPGDILIFMSGEREIRDTADALNKLNLRHTEVLPLYAR 326
Cdd:PRK11131 243 IEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELGREGPGDILIFMSGEREIRDTADALNKLNLRHTEILPLYAR 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 327 LSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEG 406
Cdd:PRK11131 323 LSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEG 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 407 ICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITADEQQTAYKL 486
Cdd:PRK11131 403 ICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQASAYKL 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 487 TPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPVDKQQASDEKHRRFHDKESDFLAFVNLWNYLG 566
Cdd:PRK11131 483 TPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVNLWNYLQ 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 567 EQQKALSSNQFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHVALLTGLLSHIGMKDADKQEYTG 646
Cdd:PRK11131 563 EQQKALSSNQFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHIGMKDAEKQEYTG 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 647 ARNARFSIFPGSGLFKKPPKWTMVAELVETSRLWGRIAARIEPEWVEPVAQHLIKRSYSEPHWERAQGAVMATEKVTVYG 726
Cdd:PRK11131 643 ARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQHLIKRSYSEPHWEKAQGAVMATEKVTLYG 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 727 LPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDDDTLFEFYDQRISHD 806
Cdd:PRK11131 723 LPIVAARKVNYGQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDDETLFEFYDQRIGHD 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 807 VISARHFDSWWKKISRETPDLLNFEKSMLIKEGAEKISKLDYPNFWHQGNLKLRLSYQFEPGADADGVTVHIPLPLLNQV 886
Cdd:PRK11131 803 VVSARHFDSWWKKASRETPELLNFEKSMLIKEGAEKVSKLDYPNFWHQGNLKLRLSYQFEPGADADGVTVHIPLPLLNQV 882
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 887 DASGFEWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVTPLELPLLDALERELRRMTGVTVDREDWHWDQVP 966
Cdd:PRK11131 883 EESGFDWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVTPLELPLLDSLERELRRMTGVTVDREDWQWDQVP 962
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 967 EHLKITFRVVNDKNKKLQEGRSLAELKNALKGKVQETLSAVADDGIEQSGLHIWSFGELPESYEQKRGNYKVKAWPALVD 1046
Cdd:PRK11131 963 DHLKITFRVVDDKNKKLAEGKDLQELKDALKGKVQETLSAVADDGIEQSGLHIWSFGELPESYEQKRGGYKVKAYPALVD 1042
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1047 ERDSVAIKLFDNPLEQQQAMWCGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLELIDDCIACGVDKLIDANGG 1126
Cdd:PRK11131 1043 EKDSVAIKLFDTELEQQQAMWQGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLDLIDDCIACGVDKLIDENGG 1122
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1127 PVWSEAGFIALHEKVRAELNDTVVDIAKQVERILTTVFNINKRLKGRVDMSMALGLSDIKAQMSGLVYRGFVTGNGFKRL 1206
Cdd:PRK11131 1123 PVWTEEGFAALHEKVRAELNDTVVDIAKQVEQILTAVFNINKRLKGRVDMTMALALSDIKAQMGGLVYRGFVTGNGWKRL 1202
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1207 GDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVESVQQAWQQWINKLPPARREDDDVKEIRWMIEELRVSYFAQQLGTPYPI 1286
Cdd:PRK11131 1203 GDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVESVQQAWQQWLNKLPPARREDEDVKEIRWMIEELRVSYFAQQLGTPYPI 1282
|
1290
....*....|..
gi 1380798330 1287 SDKRILQAMDQI 1298
Cdd:PRK11131 1283 SDKRILQAMEQI 1294
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
12-1297 |
0e+00 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 2300.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 12 LQQRLDALMLRDKQRFARRLHGVKKVKNPDAQQAIFQTMAKEIEQAAAQVALREAARPSITYPQNLPVSQKKQDILEAIR 91
Cdd:TIGR01967 1 LAEDLDHTMIRDRHRLRRRLHKLRKDHDQDRAIAALAKFRERIDAACDKVEARRQAVPEIRYPDNLPVSAKREDIAEAIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 92 DHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGYKVRFSDHVSSNTMVK 171
Cdd:TIGR01967 81 ENQVVIIAGETGSGKTTQLPKICLELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 172 LMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSG 251
Cdd:TIGR01967 161 LMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 252 RTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELGRESPGDILIFMSGEREIRDTADALNKLNLRHTEVLPLYARLSNSE 331
Cdd:TIGR01967 241 RTYPVEVRYRPLVEEQEDDDLDQLEAILDAVDELFAEGPGDILIFLPGEREIRDAAEILRKRNLRHTEILPLYARLSNKE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 332 QNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRL 411
Cdd:TIGR01967 321 QQRVFQPHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 412 YSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITADEQqtAYKLTPLGR 491
Cdd:TIGR01967 401 YSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEA--EPQLTPIGR 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 492 QLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPVDKQQASDEKHRRFHDKESDFLAFVNLWNYLGEQQKA 571
Cdd:TIGR01967 479 QLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQA 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 572 LSSNQFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHVALLTGLLSHIGMKDAdKQEYTGARNAR 651
Cdd:TIGR01967 559 LSANQFRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDE-KHEYDGARGRK 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 652 FSIFPGSGLFKKPPKWTMVAELVETSRLWGRIAARIEPEWVEPVAQHLIKRSYSEPHWERAQGAVMATEKVTVYGLPIVA 731
Cdd:TIGR01967 638 FHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGHLIKKNYFEPHWEKKRGQVMAYEKVTLYGLTLVA 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 732 ARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDDDTLFEFYDQRISHDVISAR 811
Cdd:TIGR01967 718 RRSVPYGPIDPADAREMFIRHALVEGEWQTRAAFFQANRALLEEVEELEHKARRRDILVDEQTLFDFYDGRLPEDINNAR 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 812 HFDSWWKKISRETPDLLNFEKSMLIKEGAEKISKLDYPNFWHQGNLKLRLSYQFEPGADADGVTVHIPLPLLNQVDASGF 891
Cdd:TIGR01967 798 HFDSWWKKASRKQPDLLDFPKEVLFQRRANVISAAQFPDHWHKGDLRLALSYHFEPGHGDDGVTVHIPLPLLNQLDTEDF 877
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 892 EWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVTPLELPLLDALERELRRMTGVTVDREDWHWDQVPEHLKI 971
Cdd:TIGR01967 878 DWLVPGLREEKVVALIKSLPKALRRNFVPAPDFAKACLARLPPNQGPLTDALARELRRMTGERVNPEDWDWEQLPDHLQM 957
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 972 TFRVVNDKNKKLQEGRSLAELKNALKGKVQETLSAVADDGIEQSGLHIWSFGELPESYEQKRGNYKVKAWPALVDERDSV 1051
Cdd:TIGR01967 958 NFRIVDDKGKVLAQGRDLALLKERLAGDVRAALSAVADVGIEKSGLTNWSFGPLPERMEQKTGNYKVTAYPALVDDGGSV 1037
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1052 AIKLFDNPLEQQQAMWCGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLELIDDCIACGVDKLIDANGGPVWSE 1131
Cdd:TIGR01967 1038 AIKLFDTQAEAEAAHRAGLRRLLLLQIPSPVKMLQGKLPNKAKLALYYNPLGRVEVLVDDILHAAVDRLIFENGGQVRTQ 1117
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1132 AGFIALHEKVRAELNDTVVDIAKQVERILTTVFNINKRLKGRVDMSMALGLSDIKAQMSGLVYRGFVTGNGFKRLGDTLR 1211
Cdd:TIGR01967 1118 ADFAALLAQVRAELAPEVERIAKQLEEILVLFGNIRKRLKGKIDPTQAKALSDIKAQLDKLVYQGFVRTTGPQRLSHLPR 1197
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1212 YLQAIEKRLEKLAVDPHRDRAQMLKVESVQQAWQQWINKLPPARREDDDVKEIRWMIEELRVSYFAQQLGTPYPISDKRI 1291
Cdd:TIGR01967 1198 YLKAMELRLEKLRVDPGRDRERQAEISNVQEAYDARLAKLPHERRLPAALVEIRWMIEEYRVSLFAQQLGTAYPISDKRI 1277
|
....*.
gi 1380798330 1292 LQAMDQ 1297
Cdd:TIGR01967 1278 LKYYRQ 1283
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
71-920 |
0e+00 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 1141.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 71 ITYPQNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEP 150
Cdd:COG1643 4 ITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 151 GGCIGYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPR-RPDLKVIITS 229
Cdd:COG1643 84 GETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 230 ATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEaddtERDQLQAIFDAVDELGRESPGDILIFMSGEREIRDTADA 309
Cdd:COG1643 164 ATLDAERFARLLGDAPVIESSGRTYPVEVRYRPLPAD----ERDLEDAVADAVREALAEEPGDILVFLPGEREIRRTAEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 310 LNKLNLRHTEVLPLYARLSNSEQNRVFQS--HSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEP 387
Cdd:COG1643 240 LRGRLPPDTEILPLYGRLSAAEQDRAFAPapHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 388 ISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVR 467
Cdd:COG1643 320 ISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 468 LLEELGAITADeqqtaYKLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRerpvdKQQASdekhrr 547
Cdd:COG1643 400 LLQELGALDAD-----GRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGAAG------ 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 548 fhdkeSDFLAFVNLWNYLGEQQKAlssnqfrrlcrtdYLNYLRVREWQDIYTQLRQVVKElgiPVNSEPAEYREIHVALL 627
Cdd:COG1643 464 -----SDLLARLNLWRRLREQQRE-------------FLSYLRLREWRDLARQLRRLLGE---GANEEPADYEAIGLLLA 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 628 TGLLSHIGMKDADKQEYTGARNARFSIFPGSGLFKKPpkWTMVAELVETSR-LWGRIAARIEPEWVEPVAQHLIKRsYSE 706
Cdd:COG1643 523 LAYPDRIARRRGEGGRYLLARGRGAALFPGSPLAKKE--WLVAAELVGGAAeARIRLAAPIDPEWLEELAAHLIKR-YSE 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 707 PHWERAQGAVMATEKVTVYGLPIVAARKvnySQIDPALCRELFIRHALVEGDwqTRHAFFRENLKLRAEVEELEHKS--R 784
Cdd:COG1643 600 PHWDKKRGRVVARERVRLGALVLVSRPL---PGPDPEAAREALLRALRREGL--DLLPWSKAARQLRARVEFLERKLgeR 674
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 785 RRDilVDDDTLfefydqrishdvisARHFDSWW----------KKISREtpDLLNFEKSMLIKEGAEKISKLdYPNFWHQ 854
Cdd:COG1643 675 WPD--VSDEAL--------------LATLEDWLapyltgvrslKDLKRL--DLLAALRALLPWEQQQRLDEL-APTHLTV 735
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 855 -GNLKLRLSY-------------QF----EPGAdADGvTVHIPLPLLNQV-DASGFEWQIPGLRRELVIALIKSLPKPVR 915
Cdd:COG1643 736 pSGSRLPLDYsadgppvavrlqeLFglaeTPGV-ADG-RVPVPLHLLSPAgRPLQVTWDLPGFWRGSYAEVRKELRGRYP 813
|
....*
gi 1380798330 916 RNFVP 920
Cdd:COG1643 814 KHPWP 818
|
|
| DUF3418 |
pfam11898 |
Domain of unknown function (DUF3418); This presumed domain is functionally uncharacterized. ... |
713-1295 |
0e+00 |
|
Domain of unknown function (DUF3418); This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 582 to 594 amino acids in length. This domain is found associated with pfam07717, pfam00271, pfam04408.
Pssm-ID: 463389 Cd Length: 587 Bit Score: 913.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 713 QGAVMATEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDD 792
Cdd:pfam11898 2 RGAVMAYERVTLYGLPIVARRRVNYGRIDPEEAREIFIRHALVEGEWRTRHTFFAHNRKLLEEVEELEHKARRRDILVDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 793 DTLFEFYDQRISHDVISARHFDSWWKKISRETPDLLNFEKSMLIKEGAEKISKLDYPNFWHQGNLKLRLSYQFEPGADAD 872
Cdd:pfam11898 82 ETLFDFYDARLPADVVSGRHFDKWWKKARREDPDLLDLTREDLLRHEADAVTEEDFPDTWGLGGLRLPLSYRFEPGAEDD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 873 GVTVHIPLPLLNQVDASGFEWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRV---TPLELPLLDALERELRR 949
Cdd:pfam11898 162 GVTVTVPLALLNQVSPERFDWLVPGLLEEKVTALIKSLPKALRRNFVPAPDFARAALARLerePPGDGPLLDALARALRR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 950 MTGVTVDREDWHWDQVPEHLKITFRVVNDKNKKLQEGRSLAELKNALKGKVQETLSAVADDGIEQSGLHIWSFGELPESY 1029
Cdd:pfam11898 242 LTGVRVPPDDWDLDALPPHLRMNFRVVDDRGKVLAEGRDLAALKARLAGQARAAFAAAAAASLERTGLTSWDFGDLPETV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1030 EQKRGNYKVKAWPALVDERDSVAIKLFDNPLEQQQAMWCGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLELI 1109
Cdd:pfam11898 322 ELKRGGQEVTGYPALVDEGDSVALRLFDTPAEAAAAHRAGVRRLLLLALPSPVKYLEKNLPNLQKLALAYNPLGSVEALV 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1110 DDCIACGVDKLIDANGGPVWSEAGFIALHEKVRAELNDTVVDIAKQVERILTTVFNINKRLKGRVDMSMALGLSDIKAQM 1189
Cdd:pfam11898 402 DDLIAAALDRLFLEPVPLPRDEAAFEALLEEVRARLPDTAQEVARLVEEILAAYQALRKRLKGKKSLALAAALADIRAQL 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 1190 SGLVYRGFVTGNGFKRLGDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVESVQQAWQQWINKLPPARREDDDVKEIRWMIE 1269
Cdd:pfam11898 482 DRLVPPGFVAATPWERLAHLPRYLKAIELRLEKLPADPARDRQRMAEVAPLEQRYQALLAKLPAGRPDPEELEEFRWMLE 561
|
570 580
....*....|....*....|....*.
gi 1380798330 1270 ELRVSYFAQQLGTPYPISDKRILQAM 1295
Cdd:pfam11898 562 ELRVSLFAQELGTPYPVSEKRLEKAW 587
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
77-249 |
1.45e-116 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 360.62 E-value: 1.45e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 157 KVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDPER 236
Cdd:cd17989 81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAER 160
|
170
....*....|...
gi 1380798330 237 FSRHFNNAPIIEV 249
Cdd:cd17989 161 FSRHFNNAPIIEV 173
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
77-525 |
4.03e-99 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 335.74 E-value: 4.03e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPkicMEL--GRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLP---LQLlqHGGINGKIIMLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 155 GYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKEL---LprRPDLKVIITSAT 231
Cdd:PRK11664 81 GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVqqgL--RDDLKLLIMSAT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 232 IDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIveeaddTERDQL-QAIFDAVDELGRESPGDILIFMSGEREIRDTADAL 310
Cdd:PRK11664 159 LDNDRLQQLLPDAPVIVSEGRSFPVERRYQPL------PAHQRFdEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 311 NKLNLRHTEVLPLYARLSNSEQNRVFQ-SHSGRR-IVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPI 388
Cdd:PRK11664 233 ASRVASDVLLCPLYGALSLAEQQKAILpAPAGRRkVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 389 SQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRL 468
Cdd:PRK11664 313 SQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRL 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1380798330 469 LEELGAItaDEQQtayKLTPLGRQLSQLPVDPRLARMVLEAQKHGcvrEAMIITSAL 525
Cdd:PRK11664 393 LQQLGAL--DGQG---RLTARGRKMAALGNDPRLAAMLVAAKEDD---EAALATAAK 441
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
93-249 |
3.08e-78 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 254.69 E-value: 3.08e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 93 HQVVIVAGETGSGKTTQLPKICME--LGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGYKVRFSDHVSSNTMV 170
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEdgLAKGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1380798330 171 KLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEV 249
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
77-247 |
3.34e-63 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 212.60 E-value: 3.34e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 157 KVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRR-----PDLKVIITSAT 231
Cdd:cd17978 81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSAT 160
|
170
....*....|....*.
gi 1380798330 232 IDPERFSRHFNNAPII 247
Cdd:cd17978 161 LDADLFSEYFNGAPVL 176
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
254-412 |
3.97e-63 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 212.01 E-value: 3.97e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 254 YPVEVRYRPIVEEA-----DDTERDQLQAIFDAVDEL-GRESPGDILIFMSGEREIRDTADALNKL----NLRHTEVLPL 323
Cdd:cd18791 1 FPVEVYYLEDILELlgissEKEDPDYVDAAVRLILQIhRTEEPGDILVFLPGQEEIERLCELLREEllspDLGKLLVLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 324 YARLSNSEQNRVFQSHSG--RRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCG 401
Cdd:cd18791 81 HSSLPPEEQQRVFEPPPPgvRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAG 160
|
170
....*....|.
gi 1380798330 402 RVSEGICIRLY 412
Cdd:cd18791 161 RTRPGKCYRLY 171
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
77-249 |
7.03e-62 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 208.86 E-value: 7.03e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 157 KVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDPER 236
Cdd:cd17983 81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADK 160
|
170
....*....|...
gi 1380798330 237 FSRHFNNAPIIEV 249
Cdd:cd17983 161 FADFFGNVPIFTI 173
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
77-249 |
5.80e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 206.50 E-value: 5.80e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME--LGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:cd17973 13 LPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDdeLPHQPKKLVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 155 GYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDP 234
Cdd:cd17973 93 GYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLIVMSATLDA 172
|
170
....*....|....*
gi 1380798330 235 ERFSRHFNNAPIIEV 249
Cdd:cd17973 173 GKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
75-249 |
6.22e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 206.18 E-value: 6.22e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 75 QNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:cd17971 4 ESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQEV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 155 GYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDP 234
Cdd:cd17971 84 GYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSATLDA 163
|
170
....*....|....*
gi 1380798330 235 ERFSRHFNNAPIIEV 249
Cdd:cd17971 164 VKFSQYFYEAPIFTI 178
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
77-249 |
4.54e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 195.03 E-value: 4.54e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGL-IGHTQPRRLAARTVANRIAEELQTEPGGCIG 155
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGkIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 156 YKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDPE 235
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160
|
170
....*....|....
gi 1380798330 236 RFSRHFNNAPIIEV 249
Cdd:cd17974 161 KFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
77-249 |
9.35e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 191.80 E-value: 9.35e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIK-----GLIGHTQPRRLAARTVANRIAEELqTEPG 151
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPesdnpGMIGITQPRRVAAVSMAKRVAEEL-NVFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 152 GCIGYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPD--------- 222
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170 180 190
....*....|....*....|....*....|..
gi 1380798330 223 -LKVIITSATIDPERFS---RHFNNAP-IIEV 249
Cdd:cd17982 160 pLKLVIMSATLRVEDFTenkLLFPRPPpVIKV 191
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
77-249 |
5.03e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 183.52 E-value: 5.03e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 157 KVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLP-----RRPDLKVIITSAT 231
Cdd:cd17984 81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQekspnRKEHLKVVVMSAT 160
|
170
....*....|....*...
gi 1380798330 232 IDPERFSRHFNNAPIIEV 249
Cdd:cd17984 161 LELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
77-249 |
9.43e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 182.64 E-value: 9.43e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGikgLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR---HIACTQPRRIACISLAKRVAFESLNQYGSKVAY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 157 KVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDPER 236
Cdd:cd17979 78 QIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIEL 157
|
170
....*....|...
gi 1380798330 237 FSRHFNNAPIIEV 249
Cdd:cd17979 158 FSGYFEGAPVVQV 170
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
77-242 |
1.30e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 176.89 E-value: 1.30e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKG-LIGHTQPRRLAARTVANRIAEELQTEPGGCIG 155
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGrVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 156 YKVRFSDHVSS-NTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDP 234
Cdd:cd17980 81 YCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
....*...
gi 1380798330 235 ERFSRHFN 242
Cdd:cd17980 161 EKFRDFFN 168
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
77-249 |
2.39e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 167.40 E-value: 2.39e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME-----LGRGIKGLIGHTQPRRLAARTVANRIAEELQTE-- 149
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllnGGTAQKCNIVCTQPRRISAMSLATRVCEELGCEsg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 150 PGG----CiGYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKV 225
Cdd:cd17975 81 PGGknslC-GYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170 180
....*....|....*....|....
gi 1380798330 226 IITSATIDPERFSRHFNNAPIIEV 249
Cdd:cd17975 160 ILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
77-249 |
1.74e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 159.24 E-value: 1.74e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKIC----MELGRGIKGLIGHTQPRRLAARTVANRIAEEL--QTEP 150
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFIlddaIERGKGSSCRIVCTQPRRISAISVAERVAAERaeSCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 151 GGCIGYKVRFSDHVSSN-TMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITS 229
Cdd:cd17981 81 GNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 1380798330 230 ATIDPERFSRHFNNAPIIEV 249
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
77-249 |
2.56e-43 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 155.76 E-value: 2.56e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME--LGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDdcYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 155 GYKVRFSDHVSSNTMVKLMTDGILLAEIQQ-DRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATID 233
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160
|
170
....*....|....*.
gi 1380798330 234 PERFSRHFNNAPIIEV 249
Cdd:cd17987 161 VNLFIRYFGSCPVIYI 176
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
77-249 |
1.83e-41 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 150.17 E-value: 1.83e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 157 KVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLP-RRPDLKVIITSATIDPE 235
Cdd:cd17990 81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDGD 160
|
170
....*....|....
gi 1380798330 236 RFSRHFNNAPIIEV 249
Cdd:cd17990 161 GLAALLPEAPVVES 174
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
77-249 |
2.01e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 150.33 E-value: 2.01e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME----LGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGG 152
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvlRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 153 CIGYKVRF-SDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSAT 231
Cdd:cd17976 81 NVGYQVRLeSRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*...
gi 1380798330 232 IDPERFSRHFNNAPIIEV 249
Cdd:cd17976 161 GDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
77-249 |
1.52e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 147.68 E-value: 1.52e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME--LGRGIKGL--IGHTQPRRLAARTVANRIAEELQTEPGG 152
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDnsLQGPPLPVanIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 153 CIGYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATI 232
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 1380798330 233 DPERFSRHFNNAPIIEV 249
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
77-249 |
3.34e-37 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 138.40 E-value: 3.34e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME--LGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDhyYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 155 GYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPD-LKVIITSATID 233
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSATIS 160
|
170 180
....*....|....*....|
gi 1380798330 234 PERFSRHF----NNAPIIEV 249
Cdd:cd17988 161 CKEFADYFttpnNPAYVFEV 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
77-249 |
1.47e-36 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 138.43 E-value: 1.47e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMEL----GRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGG 152
Cdd:cd17972 59 LPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDfiqnDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 153 CIGYKVRFsDHVSSNTMVKLM--TDGILLAEIQQDrlLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSA 230
Cdd:cd17972 139 SCGYSVRF-ESVLPRPHASILfcTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSA 215
|
170
....*....|....*....
gi 1380798330 231 TIDPERFSRHFNNAPIIEV 249
Cdd:cd17972 216 TIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
77-249 |
2.14e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 127.25 E-value: 2.14e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIK---GLIGHTQPRRLAARTVANRIAEELQTEPGGC 153
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHyqhGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 154 IGYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATID 233
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160
|
170
....*....|....*.
gi 1380798330 234 PERFSRHFNNAPIIEV 249
Cdd:cd17977 161 SSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
77-249 |
7.77e-32 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 122.70 E-value: 7.77e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 77 LPVSQKKQDILEAIRDHQ-VVIVAGETGSGKTTQLPKICME--LGRGI-KGLIGHTQPRRLAARTVANRIAEELQTEPGG 152
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEfaLSRGFqKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 153 CIGYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATI 232
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPA 160
|
170
....*....|....*..
gi 1380798330 233 DPERFSRHFNNAPIIEV 249
Cdd:cd17986 161 LEPKLRAFWGNPPVVHV 177
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
471-559 |
2.12e-27 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 106.58 E-value: 2.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 471 ELGAITADEQqtaykLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERpvDKQQASDEKHRRFHD 550
Cdd:smart00847 1 ELGALDDDGR-----LTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK--EKREDADAARRRFAD 73
|
....*....
gi 1380798330 551 KESDFLAFV 559
Cdd:smart00847 74 PESDHLTLL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
86-261 |
4.87e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.33 E-value: 4.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 86 ILEAIRDHQVVIVAGETGSGKTTQLPKICMELGR---GIKGLIghTQPRRLAARTVANRIAEELQTEPGGCIGY------ 156
Cdd:smart00487 17 IEALLSGLRDVILAAPTGSGKTLAALLPALEALKrgkGGRVLV--LVPTRELAEQWAEELKKLGPSLGLKVVGLyggdsk 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 157 KVRFSDHVSSNTMVKLMTDGILLAEIQQDRL-LMQYDTLIIDEAHERS--LNIDFLLGYLKELlprRPDLKVIITSATI- 232
Cdd:smart00487 95 REQLRKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL---PKNVQLLLLSATPp 171
|
170 180 190
....*....|....*....|....*....|
gi 1380798330 233 -DPERFSRHFNNAPIIEVSGRTYPVEVRYR 261
Cdd:smart00487 172 eEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
466-558 |
1.55e-21 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 90.76 E-value: 1.55e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 466 VRLLEELGAITADEQqtaykLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPVDKQQASDEKH 545
Cdd:pfam04408 2 LELLYYLGALDEDGE-----LTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKA 76
|
90 100
....*....|....*....|....*...
gi 1380798330 546 RR---------------FHDKESDFLAF 558
Cdd:pfam04408 77 ARrrrraadekarakfaRLDLEGDHLTL 104
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
622-699 |
2.02e-16 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 75.37 E-value: 2.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 622 IHVALLTGLLSHIGMKDADKQEYTGAR-NARFSIFPGSGLF---KKPPKWTMVAELVETSRLWGRIAARIEPEWVEPVAQ 697
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSdNQRVFIHPSSVLFnekTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 1380798330 698 HL 699
Cdd:pfam07717 81 HI 82
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
78-415 |
6.22e-12 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 70.01 E-value: 6.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 78 PVSQKKqdILEAIRDHQVVIVAGETGSGKTTQLPKICM---ELGRGIKGL-----------IGHTQPR----RLAARTVA 139
Cdd:PHA02653 166 PDVQLK--IFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnYLFGGFDNLdkidpnfierpIVLSLPRvalvRLHSITLL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 140 NRIA-EELQTEPggcigYKVRFSDHVSSNTMVKLMTDGILLAeiqQDRL----LMQYDTLIIDEAHERSLNIDFLLGYLK 214
Cdd:PHA02653 244 KSLGfDEIDGSP-----ISLKYGSIPDELINTNPKPYGLVFS---THKLtlnkLFDYGTVIIDEVHEHDQIGDIIIAVAR 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 215 ELLPRRPDLkvIITSATI--DPERFSRHFNNAPIIEVSGRT-YPV-EV----RYRPI--VEEADDTERDQLQAIFDAVDE 284
Cdd:PHA02653 316 KHIDKIRSL--FLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPIsEVyvknKYNPKnkRAYIEEEKKNIVTALKKYTPP 393
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 285 LGREspgdILIFMSGEREIRDTADALNKLN------LRHTEVLPLYARLSNseqnrvFQSHSGRRIVLATNVAETSLTVP 358
Cdd:PHA02653 394 KGSS----GIVFVASVSQCEEYKKYLEKRLpiydfyIIHGKVPNIDEILEK------VYSSKNPSIIISTPYLESSVTIR 463
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1380798330 359 GIKYVIDpgTARISRYSYRTKVQRLpiepISQASANQRKGRCGRVSEGICIRLYSED 415
Cdd:PHA02653 464 NATHVYD--TGRVYVPEPFGGKEMF----ISKSMRTQRKGRVGRVSPGTYVYFYDLD 514
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
311-402 |
4.17e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 60.30 E-value: 4.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 311 NKLNLRHTEVLPLYARLSNSEQNRVFQS--HSGRRIVLATNVAETSLTVPGIKYVIDPGTarisrysyrtkvqrlpiePI 388
Cdd:smart00490 5 ELLKELGIKVARLHGGLSQEEREEILDKfnNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PW 66
|
90
....*....|....
gi 1380798330 389 SQASANQRKGRCGR 402
Cdd:smart00490 67 SPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
282-403 |
6.23e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 57.61 E-value: 6.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 282 VDELGRESPGDILIFMSGereiRDTADALNKLNLRHTEVLPLYARLSNSEQNRVFQS--HSGRRIVLATNVAETSLTVPG 359
Cdd:pfam00271 7 LELLKKERGGKVLIFSQT----KKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDfrKGKIDVLVATDVAERGLDLPD 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1380798330 360 IKYVIDpgtarisrYSYrtkvqrlpiePISQASANQRKGRCGRV 403
Cdd:pfam00271 83 VDLVIN--------YDL----------PWNPASYIQRIGRAGRA 108
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
84-509 |
3.99e-08 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 57.60 E-value: 3.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 84 QDILEA-IRDHQVVIVAGETGSGKTT--QLPkICMELGRGIKGLIghtqprrLAA-RTVANRIAEELQT--EPGGcIGYK 157
Cdd:COG1204 28 AEALEAgLLEGKNLVVSAPTASGKTLiaELA-ILKALLNGGKALY-------IVPlRALASEKYREFKRdfEELG-IKVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 158 VRFSDHVSSNTMVK-----LMT----DGILLAEIqqdRLLMQYDTLIIDEAH-----ERSLNIDFLLGYLKEllpRRPDL 223
Cdd:COG1204 99 VSTGDYDSDDEWLGrydilVATpeklDSLLRNGP---SWLRDVDLVVVDEAHliddeSRGPTLEVLLARLRR---LNPEA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 224 KVIITSATID-PERFSRHFnNAPIIEVSGRtyPVE----VRYRPIVEEADDTERDQLQAIFDAVDELGREspGDILIFMS 298
Cdd:COG1204 173 QIVALSATIGnAEEIAEWL-DAELVKSDWR--PVPlnegVLYDGVLRFDDGSRRSKDPTLALALDLLEEG--GQVLVFVS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 299 GEREIRDTADAL-NKLNLRHT------------------EVLPLYARLSNSEQNRVFQSHSG-----RRIV--------- 345
Cdd:COG1204 248 SRRDAESLAKKLaDELKRRLTpeereeleelaeellevsEETHTNEKLADCLEKGVAFHHAGlpselRRLVedafregli 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 346 ---LATnvaeTSLT----VPgIKYVIdpgtarISRYsYRTKVQRLPIEPISQASanqrkGRCGRVS-----EGICIRLYS 413
Cdd:COG1204 328 kvlVAT----PTLAagvnLP-ARRVI------IRDT-KRGGMVPIPVLEFKQMA-----GRAGRPGydpygEAILVAKSS 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 414 EDD-------FLSRPE-----FTDPEILRTNLASVILQMTALGLGDIAAF--------PFVEAPDKRNIQDGVRLLEELG 473
Cdd:COG1204 391 DEAdelferyILGEPEpirskLANESALRTHLLALIASGFANSREELLDFlentfyayQYDKGDLEEVVDDALEFLLENG 470
|
490 500 510
....*....|....*....|....*....|....*.
gi 1380798330 474 AITadEQQTAYKLTPLGRQLSQLPVDPRLARMVLEA 509
Cdd:COG1204 471 FIE--EDGDRLRATKLGKLVSRLYIDPLTAAELVDG 504
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
84-235 |
4.27e-07 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 51.09 E-value: 4.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 84 QDILEAIRDHQVVIVAGETGSGKTT--QLP--KICMELGRGIKGLIghTQPRR-LAartvaNRIAEELQTEpggCIGYKV 158
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLafLLPalEALDKLDNGPQALV--LAPTReLA-----EQIYEELKKL---GKGLGL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 159 RFSDHVSSNTMVK-----------LMTDGILLAEIQQDRLLMQYDTLIIDEAHeRSLNIDF--LLGYLKELLPrrPDLKV 225
Cdd:pfam00270 75 KVASLLGGDSRKEqleklkgpdilVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFgpDLEEILRRLP--KKRQI 151
|
170
....*....|
gi 1380798330 226 IITSATIDPE 235
Cdd:pfam00270 152 LLLSATLPRN 161
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
83-512 |
8.88e-06 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 50.27 E-value: 8.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 83 KQDILEAIRDHQVVIVAGETGSGKT-TQLPKICMELGRGIKGLigHTQPrrlaARTVANRIAEELQTEPGgcIGYKVRFS 161
Cdd:PRK01172 27 QRMAIEQLRKGENVIVSVPTAAGKTlIAYSAIYETFLAGLKSI--YIVP----LRSLAMEKYEELSRLRS--LGMRVKIS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 162 --DHVSSNTMVKlMTDGILLAEIQQDRLlMQYD--------TLIIDEAH-----ERSLNIDFLLGYLKELlprRPDLKVI 226
Cdd:PRK01172 99 igDYDDPPDFIK-RYDVVILTSEKADSL-IHHDpyiindvgLIVADEIHiigdeDRGPTLETVLSSARYV---NPDARIL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 227 ITSATIDPERFSRHFNNAPIIEVSGRTYPVEV----RYRPIVEEADDTERDQLQAIFDAVDElgresPGDILIFMSGERE 302
Cdd:PRK01172 174 ALSATVSNANELAQWLNASLIKSNFRPVPLKLgilyRKRLILDGYERSQVDINSLIKETVND-----GGQVLVFVSSRKN 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 303 IRDTADALNKL-----NLRHT------------EVLPL-----YARLSNSEQNRVFQSHSGRRI--VLATNVAETSLTVP 358
Cdd:PRK01172 249 AEDYAEMLIQHfpefnDFKVSsennnvyddslnEMLPHgvafhHAGLSNEQRRFIEEMFRNRYIkvIVATPTLAAGVNLP 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 359 GiKYVIdpgTARISRYSyrtkvqRLPIEPISQASANQRKGRCGRV---SEGICIrLYSED--------DFLS-RPEFTD- 425
Cdd:PRK01172 329 A-RLVI---VRDITRYG------NGGIRYLSNMEIKQMIGRAGRPgydQYGIGY-IYAASpasydaakKYLSgEPEPVIs 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 426 ----PEILRTNLASVILQMTALGLGDIAAF---------PFVEAPDKRnIQDGVRLLEELGAItadEQQTAYKLTPLGRQ 492
Cdd:PRK01172 398 ymgsQRKVRFNTLAAISMGLASSMEDLILFynetlmaiqNGVDEIDYY-IESSLKFLKENGFI---KGDVTLRATRLGKL 473
|
490 500
....*....|....*....|
gi 1380798330 493 LSQLPVDPRLARMVLEAQKH 512
Cdd:PRK01172 474 TSDLYIDPESALILKSAFDH 493
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
95-407 |
1.02e-04 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 46.29 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 95 VVIVAgETGSGKTT-QLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGYKV--RFSDHVSSNTMVK 171
Cdd:TIGR01587 2 LVIEA-PTGYGKTEaALLWALHSIKSQKADRVIIALPTRATINAMYRRAKELFGSELVGLHHSSSfsRIKEMGDSEEFEH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 172 LMT-----------DGILLAEIQQ-----DRLLMQYDT---------LIIDEAH----ERSLNIDFLLGYLKELlprrpD 222
Cdd:TIGR01587 81 LFPlyihsndklflDPITVCTIDQvlksvFGEFGHYEFtlasianslLIFDEVHfydeYTLALILAVLEVLKDN-----D 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 223 LKVIITSATIdPERFSRHF-NNAPIIEVSGRTYPVEVRYR----PIVEEADDTERDQLQAIFDAVDElgresPGDILIFM 297
Cdd:TIGR01587 156 VPILLMSATL-PKFLKEYAeKIGYVEFNEPLDLKEERRFEnhrfILIESDKVGEISSLERLLEFIKK-----GGSIAIIV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 298 SGEREIRDTADALNKLNlrHTEVLPLY---------ARLSNSEQNRVFQSHSGRRIVlATNVAETSLTVPGIKYVIDPGt 368
Cdd:TIGR01587 230 NTVDRAQEFYQQLKEKA--PEEEIILYhsrftekdrAKKEAELLREMKKSNEKFVIV-ATQVIEASLDISADVMITELA- 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 1380798330 369 arisrysyrtkvqrlpiePISqaSANQRKGRCGRVSEGI 407
Cdd:TIGR01587 306 ------------------PID--SLIQRLGRLHRYGRKI 324
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
95-412 |
1.19e-04 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 45.88 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 95 VVIVAgETGSGKTT-QLPKICMELGRGIKGLIGHTQPRRLAARTVANRiAEELQTEPGGCIGYKV--RFSDHVSSNTMVK 171
Cdd:cd09639 2 LVIEA-PTGYGKTEaALLWALHSLKSQKADRVIIALPTRATINAMYRR-AKEAFGETGLYHSSILssRIKEMGDSEEFEH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 172 LMT-----------DGILLAEIQQ-----DRLLMQYDT---------LIIDEAH----ERSLNIDFLLGYLKELlprrpD 222
Cdd:cd09639 80 LFPlyihsndtlflDPITVCTIDQvlksvFGEFGHYEFtlasianslLIFDEVHfydeYTLALILAVLEVLKDN-----D 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 223 LKVIITSATIdPERFSRHF-NNAPIIEVSGRTY-PVEVRYRPIVEEADDTERDQLQAIFDAVDElgresPGDILIFMSGE 300
Cdd:cd09639 155 VPILLMSATL-PKFLKEYAeKIGYVEENEPLDLkPNERAPFIKIESDKVGEISSLERLLEFIKK-----GGSVAIIVNTV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 301 REIRDTADALNKLNlRHTEVLPLYARLSNS------EQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGtarisry 374
Cdd:cd09639 229 DRAQEFYQQLKEKG-PEEEIMLIHSRFTEKdrakkeAELLLEFKKSEKFVIVATQVIEASLDISVDVMITELA------- 300
|
330 340 350
....*....|....*....|....*....|....*...
gi 1380798330 375 syrtkvqrlpiePISqaSANQRKGRCGRVSEGICIRLY 412
Cdd:cd09639 301 ------------PID--SLIQRLGRLHRYGEKNGEEVY 324
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
96-231 |
2.22e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 42.78 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 96 VIVAGETGSGKTT--QLPKICMELGRGIKGLIghTQPRrlaaRTVANRIAEELQTEPGgcIGYKVRFSDHVSS---NTMV 170
Cdd:cd00046 4 VLITAPTGSGKTLaaLLAALLLLLKKGKKVLV--LVPT----KALALQTAERLRELFG--PGIRVAVLVGGSSaeeREKN 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1380798330 171 KLMTDGILLAEIQQDRLLMQ---------YDTLIIDEAHERSLNIDF-LLGYLKELLPRRPDLKVIITSAT 231
Cdd:cd00046 76 KLGDADIIIATPDMLLNLLLredrlflkdLKLIIVDEAHALLIDSRGaLILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
94-250 |
8.93e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 41.38 E-value: 8.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 94 QVVIVAGETGSGKTTQ-LPKICMELGR-GIKGLIghtqprrLA-ARTVANRIAEELQTEPggcIGYK--VRFSDHvSSNT 168
Cdd:cd17931 2 QLTVLDLHPGAGKTTRvLPQIIREAIKkRLRTLV-------LApTRVVAAEMYEALRGLP---IRYRtgAVKEEH-GGNE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 169 MVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIDFLLGYLKELLpRRPDLKVIITSATIDPERFSRHFNNAPIIE 248
Cdd:cd17931 71 IVDYMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHTRV-EMGEAAVIFMTATPPGTVTPFPQSNHPIED 149
|
..
gi 1380798330 249 VS 250
Cdd:cd17931 150 FE 151
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
84-364 |
5.25e-03 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 41.16 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 84 QDILEAIRDH------QVVIVAGeTGSGKTTQLPKICMELGRGIKGLIghtqprrLAARTV-ANRIAEELQTEPGGCIGY 156
Cdd:COG1061 86 QEALEALLAAlergggRGLVVAP-TGTGKTVLALALAAELLRGKRVLV-------LVPRRElLEQWAEELRRFLGDPLAG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 157 kvrfSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAHERSLNIdfllgyLKELLPRRPDLKVIITSATidPER 236
Cdd:COG1061 158 ----GGKKDSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHHAGAPS------YRRILEAFPAAYRLGLTAT--PFR 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 237 -------FSRHFN---NAPIIEVSGRTYPVEVRYRPI----------VEEADDTERDQL----QAIFDAVDELGRESPGD 292
Cdd:COG1061 226 sdgreilLFLFDGivyEYSLKEAIEDGYLAPPEYYGIrvdltderaeYDALSERLREALaadaERKDKILRELLREHPDD 305
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1380798330 293 --ILIFMSGEREIRDTADALNKLNLRhteVLPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVI 364
Cdd:COG1061 306 rkTLVFCSSVDHAEALAELLNEAGIR---AAVVTGDTPKKEREEILEafRDGELRILVTVDVLNEGVDVPRLDVAI 378
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
93-229 |
5.94e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.89 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380798330 93 HQVVIVAGETGSGKTTQLPKICMELGRGIKGLIghtqprRLAARTVANRIAEELQTEPGGcigykvrfsdhvssntMVKL 172
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARELGPPGGGVI------YIDGEDILEEVLDQLLLIIVG----------------GKKA 59
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1380798330 173 MTDGILLAEIQQDRLL-MQYDTLIIDEAH------ERSLNIDFLLGYLKELLPRRPDLKVIITS 229
Cdd:smart00382 60 SGSGELRLRLALALARkLKPDVLILDEITslldaeQEALLLLLEELRLLLLLKSEKNLTVILTT 123
|
|
| |
