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Conserved domains on  [gi|1382540383|gb|PUX30218|]
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FAD-binding oxidoreductase [Cronobacter sakazakii]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11429741)

FAD/NAD(P)-binding oxidoreductase that catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.30.9.10
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0050660
SCOP:  3000055

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
27-397 1.67e-91

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 280.64  E-value: 1.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  27 QCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAARIGFGASGRNGGQVVNSYSRDIDVIEARygaetarmlgsMMFEGGEI 106
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSGASGRNAGQLRPGLAALADRALVR-----------LAREALDL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 107 IRERIKRYDIQCDYRP-GGMFVALNRKQYLGLMEQKASWERYGNNgLELLDADAVRGE---IASQRYTGALLDHNGGHIH 182
Cdd:COG0665    71 WRELAAELGIDCDFRRtGVLYLARTEAELAALRAEAEALRALGLP-VELLDAAELRERepgLGSPDYAGGLYDPDDGHVD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 183 PLNLALGEAEAIRSLGGKIFEQSAAVSITH--GQPAVVKTAQGQVTARYVIVAGNAYLGtRLEPALARR--SMPCGTQVV 258
Cdd:COG0665   150 PAKLVRALARAARAAGVRIREGTPVTGLERegGRVTGVRTERGTVRADAVVLAAGAWSA-RLLPMLGLRlpLRPVRGYVL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 259 TTEPLAPdvaaslLPNNYCVEDCNYlldYYRLTADNRLLYGGGVVYGARDPD---DIDRLIMPKLLKTFPQLKGVKIDYR 335
Cdd:COG0665   229 VTEPLPD------LPLRPVLDDTGV---YLRPTADGRLLVGGTAEPAGFDRAptpERLEALLRRLRRLFPALADAEIVRA 299

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1382540383 336 WTGNFLLTLSRMPQFGRLEN--NIYYMQGDSGHGVTCTHLAGKLISEALRGDAERFDAFATLPH 397
Cdd:COG0665   300 WAGLRPMTPDGLPIIGRLPGapGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPD 363
 
Name Accession Description Interval E-value
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
27-397 1.67e-91

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 280.64  E-value: 1.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  27 QCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAARIGFGASGRNGGQVVNSYSRDIDVIEARygaetarmlgsMMFEGGEI 106
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSGASGRNAGQLRPGLAALADRALVR-----------LAREALDL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 107 IRERIKRYDIQCDYRP-GGMFVALNRKQYLGLMEQKASWERYGNNgLELLDADAVRGE---IASQRYTGALLDHNGGHIH 182
Cdd:COG0665    71 WRELAAELGIDCDFRRtGVLYLARTEAELAALRAEAEALRALGLP-VELLDAAELRERepgLGSPDYAGGLYDPDDGHVD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 183 PLNLALGEAEAIRSLGGKIFEQSAAVSITH--GQPAVVKTAQGQVTARYVIVAGNAYLGtRLEPALARR--SMPCGTQVV 258
Cdd:COG0665   150 PAKLVRALARAARAAGVRIREGTPVTGLERegGRVTGVRTERGTVRADAVVLAAGAWSA-RLLPMLGLRlpLRPVRGYVL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 259 TTEPLAPdvaaslLPNNYCVEDCNYlldYYRLTADNRLLYGGGVVYGARDPD---DIDRLIMPKLLKTFPQLKGVKIDYR 335
Cdd:COG0665   229 VTEPLPD------LPLRPVLDDTGV---YLRPTADGRLLVGGTAEPAGFDRAptpERLEALLRRLRRLFPALADAEIVRA 299

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1382540383 336 WTGNFLLTLSRMPQFGRLEN--NIYYMQGDSGHGVTCTHLAGKLISEALRGDAERFDAFATLPH 397
Cdd:COG0665   300 WAGLRPMTPDGLPIIGRLPGapGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPD 363
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 29-380 5.73e-66

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 214.18  E-value: 5.73e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  29 DVCIVGGGYTGLSSALHLVEQGYDVVLLEA-ARIGFGASGRNGGQVVNSYSRDIDVIEARYGAETARMLgsmmfeggeii 107
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERgDDPGSGASGRNAGLIHPGLRYLEPSELARLALEALDLW----------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 108 RERIKRYDIQCDYRPGGMFVALNRKQYLGLMEQKASWERYGnNGLELLDADAVR-GEIASQRYTGALLDHNGGHIHPLNL 186
Cdd:pfam01266  70 EELEEELGIDCGFRRCGVLVLARDEEEEALEKLLAALRRLG-VPAELLDAEELReLEPLLPGLRGGLFYPDGGHVDPARL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 187 ALGEAEAIRSLGGKIFEQSAAVSITHGQPavVKTAQGQVTARYVIVAGNAYLGTRLEPALARRSMPCGTQVVTTEPLAPD 266
Cdd:pfam01266 149 LRALARAAEALGVRIIEGTEVTGIEEEGG--VWGVVTTGEADAVVNAAGAWADLLALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 267 VAASLLPnnycVEDCNYLLDYYRLTADNRLLYGGGVVYGARDPDDID----RLIMPKLLKTFPQLkgVKIDYRWTGnFLL 342
Cdd:pfam01266 227 LLILPVP----ITVDPGRGVYLRPRADGRLLLGGTDEEDGFDDPTPDpeeiEELLEAARRLFPAL--ADIERAWAG-LRP 299

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1382540383 343 TLSRMPQFGRLEN-NIYYMQGDSGHGVTCTHLAGKLISE 380
Cdd:pfam01266 300 LPDGLPIIGRPGSpGLYLATGHGGHGLTLAPGIGKLLAE 338
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
28-234 7.32e-09

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 57.14  E-value: 7.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  28 CDVCIVGGGYTGLSSALHLVEQ--GYDVVLLE-AARIGFGASGRNGGqvvnsysrdidVIEA----RYGAETARmlgsmm 100
Cdd:PRK11728    3 YDFVIIGGGIVGLSTAMQLQERypGARIAVLEkESGPARHQTGHNSG-----------VIHAgvyyTPGSLKAR------ 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 101 F--EGGEIIRERIKRYDIQCDyRPGGMFVALNRKQyLGLMEqkASWERYGNNGL--ELLDADAVRGEIASQRYTGALLDH 176
Cdd:PRK11728   66 FcrRGNEATKAFCDQHGIPYE-ECGKLLVATSELE-LERME--ALYERARANGIevERLDAEELREREPNIRGLGAIFVP 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 177 NGGHIHPLNLALGEAEAIRSLGGKIFEQSAAVSIT-HGQPAVVKTAQGQVTARYVIV-AG 234
Cdd:PRK11728  142 STGIVDYRAVAEAMAELIQARGGEIRLGAEVTALDeHANGVVVRTTQGEYEARTLINcAG 201
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 29-244 2.34e-07

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 52.52  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  29 DVCIVGGGYTGLSSALHLVEQGYDVVLLEAarigFGASGRNGgqvvnSYSRDIDVIEARYGAETARMlgsMMFEGGEIIR 108
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKKTLLLEQ----FDLPHSRG-----SSHGQSRIIRKAYPEDFYTP---MMLECYQLWA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 109 ERIKRYDIQCdYRPGGMFVaLNRKQYLGLMEQKASWERYGnnglelLDADAVRGEIASQRYTG--------ALLDHNGGH 180
Cdd:TIGR01377  70 QLEKEAGTKL-HRQTGLLL-LGPKENQFLKTIQATLSRHG------LEHELLSSKQLKQRFPNirvprnevGLLDPNGGV 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1382540383 181 IHPLNLALGEAEAIRSLGGKIFEQSAAVSIT-HGQPAVVKTAQGQVTARYVIVAGNAYLGTRLEP 244
Cdd:TIGR01377 142 LYAEKALRALQELAEAHGATVRDGTKVVEIEpTELLVTVKTTKGSYQANKLVVTAGAWTSKLLSP 206
 
Name Accession Description Interval E-value
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
27-397 1.67e-91

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 280.64  E-value: 1.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  27 QCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAARIGFGASGRNGGQVVNSYSRDIDVIEARygaetarmlgsMMFEGGEI 106
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSGASGRNAGQLRPGLAALADRALVR-----------LAREALDL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 107 IRERIKRYDIQCDYRP-GGMFVALNRKQYLGLMEQKASWERYGNNgLELLDADAVRGE---IASQRYTGALLDHNGGHIH 182
Cdd:COG0665    71 WRELAAELGIDCDFRRtGVLYLARTEAELAALRAEAEALRALGLP-VELLDAAELRERepgLGSPDYAGGLYDPDDGHVD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 183 PLNLALGEAEAIRSLGGKIFEQSAAVSITH--GQPAVVKTAQGQVTARYVIVAGNAYLGtRLEPALARR--SMPCGTQVV 258
Cdd:COG0665   150 PAKLVRALARAARAAGVRIREGTPVTGLERegGRVTGVRTERGTVRADAVVLAAGAWSA-RLLPMLGLRlpLRPVRGYVL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 259 TTEPLAPdvaaslLPNNYCVEDCNYlldYYRLTADNRLLYGGGVVYGARDPD---DIDRLIMPKLLKTFPQLKGVKIDYR 335
Cdd:COG0665   229 VTEPLPD------LPLRPVLDDTGV---YLRPTADGRLLVGGTAEPAGFDRAptpERLEALLRRLRRLFPALADAEIVRA 299

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1382540383 336 WTGNFLLTLSRMPQFGRLEN--NIYYMQGDSGHGVTCTHLAGKLISEALRGDAERFDAFATLPH 397
Cdd:COG0665   300 WAGLRPMTPDGLPIIGRLPGapGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPD 363
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 29-380 5.73e-66

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 214.18  E-value: 5.73e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  29 DVCIVGGGYTGLSSALHLVEQGYDVVLLEA-ARIGFGASGRNGGQVVNSYSRDIDVIEARYGAETARMLgsmmfeggeii 107
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERgDDPGSGASGRNAGLIHPGLRYLEPSELARLALEALDLW----------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 108 RERIKRYDIQCDYRPGGMFVALNRKQYLGLMEQKASWERYGnNGLELLDADAVR-GEIASQRYTGALLDHNGGHIHPLNL 186
Cdd:pfam01266  70 EELEEELGIDCGFRRCGVLVLARDEEEEALEKLLAALRRLG-VPAELLDAEELReLEPLLPGLRGGLFYPDGGHVDPARL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 187 ALGEAEAIRSLGGKIFEQSAAVSITHGQPavVKTAQGQVTARYVIVAGNAYLGTRLEPALARRSMPCGTQVVTTEPLAPD 266
Cdd:pfam01266 149 LRALARAAEALGVRIIEGTEVTGIEEEGG--VWGVVTTGEADAVVNAAGAWADLLALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 267 VAASLLPnnycVEDCNYLLDYYRLTADNRLLYGGGVVYGARDPDDID----RLIMPKLLKTFPQLkgVKIDYRWTGnFLL 342
Cdd:pfam01266 227 LLILPVP----ITVDPGRGVYLRPRADGRLLLGGTDEEDGFDDPTPDpeeiEELLEAARRLFPAL--ADIERAWAG-LRP 299

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1382540383 343 TLSRMPQFGRLEN-NIYYMQGDSGHGVTCTHLAGKLISE 380
Cdd:pfam01266 300 LPDGLPIIGRPGSpGLYLATGHGGHGLTLAPGIGKLLAE 338
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
27-233 6.33e-13

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 69.79  E-value: 6.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  27 QCDVCIVGGGYTGLSSALHLVE-QGYDVVLLEA-ARIGFGASGRNGGqVVNS------YSrdidvIEARYGAETARMLGs 98
Cdd:COG0579     4 MYDVVIIGAGIVGLALARELSRyEDLKVLVLEKeDDVAQESSGNNSG-VIHAglyytpGS-----LKARLCVEGNELFY- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  99 mmfeggEIIRERikryDIQcDYRPGGMFVALNRKQYLGLMEQKASWERYGNNGLELLDADAVRgEI---ASQRYTGALLD 175
Cdd:COG0579    77 ------ELCREL----GIP-FKRCGKLVVATGEEEVAFLEKLYERGKANGVPGLEILDREELR-ELeplLSDEGVAALYS 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1382540383 176 HNGGHIHPLNLALGEAEAIRSLGGKIFEQSAAVSITHGQPAV-VKTAQGQVTARYVIVA 233
Cdd:COG0579   145 PSTGIVDPGALTRALAENAEANGVELLLNTEVTGIEREGDGWeVTTNGGTIRARFVINA 203
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
28-234 7.32e-09

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 57.14  E-value: 7.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  28 CDVCIVGGGYTGLSSALHLVEQ--GYDVVLLE-AARIGFGASGRNGGqvvnsysrdidVIEA----RYGAETARmlgsmm 100
Cdd:PRK11728    3 YDFVIIGGGIVGLSTAMQLQERypGARIAVLEkESGPARHQTGHNSG-----------VIHAgvyyTPGSLKAR------ 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 101 F--EGGEIIRERIKRYDIQCDyRPGGMFVALNRKQyLGLMEqkASWERYGNNGL--ELLDADAVRGEIASQRYTGALLDH 176
Cdd:PRK11728   66 FcrRGNEATKAFCDQHGIPYE-ECGKLLVATSELE-LERME--ALYERARANGIevERLDAEELREREPNIRGLGAIFVP 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 177 NGGHIHPLNLALGEAEAIRSLGGKIFEQSAAVSIT-HGQPAVVKTAQGQVTARYVIV-AG 234
Cdd:PRK11728  142 STGIVDYRAVAEAMAELIQARGGEIRLGAEVTALDeHANGVVVRTTQGEYEARTLINcAG 201
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
27-233 1.35e-07

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 53.39  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  27 QCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAA-RIGfgasGRN-------GGQVVN--------SYSRDIDVIEaRYGA 90
Cdd:COG1231     7 GKDVVIVGAGLAGLAAARELRKAGLDVTVLEARdRVG----GRVwtlrfgdDGLYAElgamrippSHTNLLALAR-ELGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  91 ETARMLG----SMMFEGGEIIRERikryDIQCDYRpgGMFVALNRkqylgLMEQKASWERYGNNGLELLD----ADAVRG 162
Cdd:COG1231    82 PLEPFPNengnALLYLGGKRVRAG----EIAADLR--GVAELLAK-----LLRALAAALDPWAHPAAELDreslAEWLRR 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 163 EIASQR----YTGALLDHNGGHIHPLNL---------ALGEAEAIR--------------SLGGKIFEQSAAVSITHGQP 215
Cdd:COG1231   151 NGASPSarrlLGLLGAGEYGADPDELSLldllryaasAGGGAQQFRivggmdqlpralaaELGDRIRLGAPVTRIRQDGD 230

                         250       260
                  ....*....|....*....|
gi 1382540383 216 AV-VKTAQGQ-VTARYVIVA 233
Cdd:COG1231   231 GVtVTTDDGGtVRADAVIVT 250
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 29-244 2.34e-07

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 52.52  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  29 DVCIVGGGYTGLSSALHLVEQGYDVVLLEAarigFGASGRNGgqvvnSYSRDIDVIEARYGAETARMlgsMMFEGGEIIR 108
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKKTLLLEQ----FDLPHSRG-----SSHGQSRIIRKAYPEDFYTP---MMLECYQLWA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 109 ERIKRYDIQCdYRPGGMFVaLNRKQYLGLMEQKASWERYGnnglelLDADAVRGEIASQRYTG--------ALLDHNGGH 180
Cdd:TIGR01377  70 QLEKEAGTKL-HRQTGLLL-LGPKENQFLKTIQATLSRHG------LEHELLSSKQLKQRFPNirvprnevGLLDPNGGV 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1382540383 181 IHPLNLALGEAEAIRSLGGKIFEQSAAVSIT-HGQPAVVKTAQGQVTARYVIVAGNAYLGTRLEP 244
Cdd:TIGR01377 142 LYAEKALRALQELAEAHGATVRDGTKVVEIEpTELLVTVKTTKGSYQANKLVVTAGAWTSKLLSP 206
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 29-60 4.38e-07

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 51.78  E-value: 4.38e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1382540383  29 DVCIVGGGYTGLSSALHLVEQGYDVVLLEAAR 60
Cdd:COG3349     5 RVVVVGGGLAGLAAAVELAEAGFRVTLLEARP 36
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 27-62 1.88e-06

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 49.83  E-value: 1.88e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1382540383  27 QCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAA-RIG 62
Cdd:COG1232     1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASdRVG 37
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 27-71 2.34e-06

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 49.45  E-value: 2.34e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1382540383  27 QCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAARIGFGASGRNGG 71
Cdd:COG1053     3 EYDVVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGGHTAAAQG 47
PRK07233 PRK07233
hypothetical protein; Provisional
 30-71 8.30e-06

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 47.96  E-value: 8.30e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1382540383  30 VCIVGGGYTGLSSALHLVEQGYDVVLLEAARI--GFGASGRNGG 71
Cdd:PRK07233    2 IAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQlgGLAASFEFGG 45
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
32-90 4.44e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 41.36  E-value: 4.44e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1382540383  32 IVGGGYTGLSSALHLVEQGYDVVLLEAARigfgasgRNGGqvvNSYSRDIDVIEARYGA 90
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRD-------RLGG---NAYSYRVPGYVFDYGA 49
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
23-129 5.67e-05

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 45.39  E-value: 5.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  23 TESLQCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAARIGFGASGRNGGqVVNSysrdidviEARYG---AETARmlgsm 99
Cdd:PRK11101    2 RDSQETDVIIIGGGATGAGIARDCALRGLRCILVERHDIATGATGRNHG-LLHS--------GARYAvtdAESAR----- 67

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1382540383 100 mfeggEIIRE-RI-KRYDIQCDYRPGGMFVAL 129
Cdd:PRK11101   68 -----ECISEnQIlKRIARHCVEPTDGLFITL 94
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 29-62 7.96e-05

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 44.47  E-value: 7.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1382540383  29 DVCIVGGGYTGLSSALHLVEQGYDVVLLEAA-RIG 62
Cdd:COG2072     8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKAdDVG 42
PRK12839 PRK12839
FAD-dependent oxidoreductase;
25-87 1.72e-04

FAD-dependent oxidoreductase;


Pssm-ID: 237223 [Multi-domain]  Cd Length: 572  Bit Score: 43.66  E-value: 1.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1382540383  25 SLQCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAARIGFGASGRNGGQV---VNSYSRDIDVIEAR 87
Cdd:PRK12839    6 THTYDVVVVGSGAGGLSAAVAAAYGGAKVLVVEKASTCGGATAWSGGWMwtpGNSLARADGVVEDK 71
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 27-68 4.57e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 41.85  E-value: 4.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1382540383  27 QCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAARiGFGASGR 68
Cdd:COG0654     3 RTDVLIVGGGPAGLALALALARAGIRVTVVERAP-PPRPDGR 43
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
18-61 4.81e-04

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 42.53  E-value: 4.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1382540383  18 PFPTLTESLQCDVCIVGGGYTGLSSALHLVEQGYDVVLLEAARI 61
Cdd:PRK13800    4 PALTDALRLDCDVLVIGGGTAGTMAALTAAEHGANVLLLEKAHV 47
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 28-57 5.39e-04

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 41.93  E-value: 5.39e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1382540383  28 CDVCIVGGGYTGLSSALHLVEQGYDVVLLE 57
Cdd:pfam01494   2 TDVLIVGGGPAGLMLALLLARAGVRVVLVE 31
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
11-57 5.84e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 42.15  E-value: 5.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1382540383  11 ASANPHAPFPTLTESLQCDVCIVGGGYTGLSSALHLVEQGYDVVLLE 57
Cdd:COG1148   124 AKAKLLEPLEPIKVPVNKRALVIGGGIAGMTAALELAEQGYEVYLVE 170
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 29-255 7.63e-04

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 41.76  E-value: 7.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  29 DVCIVGGGYTGLSSALHLVEQGYDVVLLEAA-RIGfgasGRnggqvVNSYSRD---IDViearyGAetarMLGSMMFEGG 104
Cdd:COG1233     5 DVVVIGAGIGGLAAAALLARAGYRVTVLEKNdTPG----GR-----ARTFERPgfrFDV-----GP----SVLTMPGVLE 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 105 EIIRE-------RIKRYDIQCDYR-PGGMFVALNR--------------------KQYLGLMEQK--ASWERYGNNGL-- 152
Cdd:COG1233    67 RLFRElgledylELVPLDPAYRVPfPDGRALDLPRdlertaaelerlfpgdaeayRRFLAELRRLydALLEDLLYRPLls 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 153 --ELLDA---------------DAVRGEIASQR----------YTG-------------ALLDHNGGHIHPL----NLAL 188
Cdd:COG1233   147 lrDLLRPlalarllrlllrslrDLLRRYFKDPRlrallagqalYLGlspdrtpalyaliAYLEYAGGVWYPKggmgALAD 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383 189 GEAEAIRSLGGKIFEQSAAVSIT--HGQPAVVKTAQGQ-VTARYVIVA-----------GNAYLGTRLEPALARRSMPCG 254
Cdd:COG1233   227 ALARLAEELGGEIRTGAEVERILveGGRATGVRLADGEeIRADAVVSNadpahtylrllGEEALPARYRRRLERFRYSPS 306


                  .
gi 1382540383 255 T 255
Cdd:COG1233   307 A 307
PLN02976 PLN02976
amine oxidase
 26-62 1.08e-03

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 41.39  E-value: 1.08e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1382540383   26 LQCD------VCIVGGGYTGLSSALHLVEQGYDVVLLEA-ARIG 62
Cdd:PLN02976   686 VLCDsvdrkkIIVVGAGPAGLTAARHLQRQGFSVTVLEArSRIG 729
PRK00711 PRK00711
D-amino acid dehydrogenase;
30-78 1.10e-03

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 40.94  E-value: 1.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1382540383  30 VCIVGGGYTGLSSALHLVEQGYDVVLLE-AARIGFGASGRNGGQVVNSYS 78
Cdd:PRK00711    3 VVVLGSGVIGVTSAWYLAQAGHEVTVIDrQPGPALETSFANAGQISPGYA 52
PRK08163 PRK08163
3-hydroxybenzoate 6-monooxygenase;
30-116 1.30e-03

3-hydroxybenzoate 6-monooxygenase;


Pssm-ID: 181262 [Multi-domain]  Cd Length: 396  Bit Score: 40.79  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  30 VCIVGGGYTGLSSALHLVEQGYDVVLLE-AARIG-FGAS---GRNG---------GQVVNS---YSRDIDVIEARYGAET 92
Cdd:PRK08163    7 VLIVGGGIGGLAAALALARQGIKVKLLEqAAEIGeIGAGiqlGPNAfsaldalgvGEAARQravFTDHLTMMDAVDAEEV 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1382540383  93 ARMlgsmmfEGGEIIRER-------IKRYDI 116
Cdd:PRK08163   87 VRI------PTGQAFRARfgnpyavIHRADI 111
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 38-117 1.95e-03

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 40.17  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382540383  38 TGLSSALHLVEQGYDVVLLEAA-RIGfgasGRnggqvVNSYSRDIDVIEarygaetarmLGSMMFEGGEI-IRERIKRYD 115
Cdd:pfam01593   2 AGLAAARELLRAGHDVTVLEARdRVG----GR-----IRTVRDDGFLIE----------LGAMWFHGAQPpLLALLKELG 62


                  ..
gi 1382540383 116 IQ 117
Cdd:pfam01593  63 LE 64
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 11-67 2.69e-03

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 40.21  E-value: 2.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1382540383  11 ASANPHAPFPTLTESLQC-DVCIVGGGYTGLSSALHLVEQGYDVVLLEA-ARIGFGASG 67
Cdd:PRK01747  243 LPAPLAAPWFARPGSPKArDAAIIGGGIAGAALALALARRGWQVTLYEAdEAPAQGASG 301
PRK07364 PRK07364
FAD-dependent hydroxylase;
10-58 2.91e-03

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 39.62  E-value: 2.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1382540383  10 AASANPHAPFPTLteSLQCDVCIVGGGYTGLSSALHLVEQGYDVVLLEA 58
Cdd:PRK07364    3 LTAATSPTLPSTR--SLTYDVAIVGGGIVGLTLAAALKDSGLRIALIEA 49
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 30-62 3.44e-03

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 39.45  E-value: 3.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1382540383  30 VCIVGGGYTGLSSA--LHLVEQGYDVVLLEAA-RIG 62
Cdd:PRK11883    3 VAIIGGGITGLSAAyrLHKKGPDADITLLEASdRLG 38
PRK06185 PRK06185
FAD-dependent oxidoreductase;
23-58 4.34e-03

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 39.07  E-value: 4.34e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1382540383  23 TESLQCDVCIVGGGYTGLSSALHLVEQGYDVVLLEA 58
Cdd:PRK06185    2 AEVETTDCCIVGGGPAGMMLGLLLARAGVDVTVLEK 37
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
20-57 4.84e-03

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 39.12  E-value: 4.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1382540383  20 PTLTESLQCDVCIVGGGYTGLSSALHLVEQGYDVVLLE 57
Cdd:PRK06183    3 AQHPDAHDTDVVIVGAGPVGLTLANLLGQYGVRVLVLE 40
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 29-60 6.29e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 38.45  E-value: 6.29e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1382540383  29 DVCIVGGGYTGLSSALHLVEQGYDVVLLEAAR 60
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEDEG 33
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 30-96 8.60e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 37.74  E-value: 8.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1382540383  30 VCIVGGGYTGLSSALHLVEQGYDVVLLEAARIGFGASGRNGGQVVNSYSRDIDV-IEAryGAETARML 96
Cdd:COG0569    98 VIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVlEEA--GIEDADAV 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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