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Conserved domains on  [gi|1382703435|gb|PUY90458|]
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AraC family transcriptional regulator [Cronobacter sakazakii]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12820790)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 158-274 5.29e-22

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 93.30  E-value: 5.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 158 YARHAPQAAEGAHRFDRVREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAG-LP 236
Cdd:COG4977   198 FSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLS 277

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1382703435 237 AADVAAAVGLTDQPHLTRAFTRRYGITPARYQKQVARQ 274
Cdd:COG4977   278 IEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 2.14e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 87.91  E-value: 2.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  16 RFRQLPALPGVELYHAHIAHYAFEPHTHEAFGIGAIELGAERFRYRGAQHVAAVNSLVTMNPDELHTGEAATQQGWRYRM 95
Cdd:COG2207     2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  96 IYLEPETLAQLTGERHWWFAEVERHDPLRARQTGQLIAALWSAPDTLAQQGLLLDLIDTFRPYARHAPQAAEGAHRFDRV 175
Cdd:COG2207    82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 176 REFLyenyMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAG-LPAADVAAAVGLTDQPHLTR 254
Cdd:COG2207   162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                         250       260
                  ....*....|....*....|
gi 1382703435 255 AFTRRYGITPARYQKQVARQ 274
Cdd:COG2207   238 AFKKRFGVTPSEYRKRLRAR 257
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 158-274 5.29e-22

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 93.30  E-value: 5.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 158 YARHAPQAAEGAHRFDRVREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAG-LP 236
Cdd:COG4977   198 FSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLS 277

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1382703435 237 AADVAAAVGLTDQPHLTRAFTRRYGITPARYQKQVARQ 274
Cdd:COG4977   278 IEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
186-267 1.29e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.45  E-value: 1.29e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  186 PLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAG-LPAADVAAAVGLTDQPHLTRAFTRRYGITP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 1382703435  265 ARY 267
Cdd:smart00342  81 SEY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 2.14e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 87.91  E-value: 2.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  16 RFRQLPALPGVELYHAHIAHYAFEPHTHEAFGIGAIELGAERFRYRGAQHVAAVNSLVTMNPDELHTGEAATQQGWRYRM 95
Cdd:COG2207     2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  96 IYLEPETLAQLTGERHWWFAEVERHDPLRARQTGQLIAALWSAPDTLAQQGLLLDLIDTFRPYARHAPQAAEGAHRFDRV 175
Cdd:COG2207    82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 176 REFLyenyMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAG-LPAADVAAAVGLTDQPHLTR 254
Cdd:COG2207   162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                         250       260
                  ....*....|....*....|
gi 1382703435 255 AFTRRYGITPARYQKQVARQ 274
Cdd:COG2207   238 AFKKRFGVTPSEYRKRLRAR 257
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 23-152 4.11e-20

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 84.02  E-value: 4.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  23 LPGVELYHAHIAHYAFEPHTHEAFGIGAIELGAERFRYRGAQHVAAVNSLVTMNPDELHTGEAATQQGWRYRMIYLEPET 102
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1382703435 103 LAQLTGERHW--WFAEVERHDPLRARQTGQLIAALWSA--PDTLAQQGLLLDLI 152
Cdd:pfam02311  81 LERILADISIlaGGPLPLLRDPELAALLRALFRLLEEAgrSDDLLAEALLYQLL 134
HTH_18 pfam12833
Helix-turn-helix domain;
192-270 1.28e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.10  E-value: 1.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 192 IAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLA--AGLPAADVAAAVGLTDQPHLTRAFTRRYGITPARYQK 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLedTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1382703435 270 Q 270
Cdd:pfam12833  81 R 81
ftrA PRK09393
transcriptional activator FtrA; Provisional
 161-273 3.50e-14

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 71.53  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 161 HAPQAAEGAHRFDRVREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFL-AAGLPAAD 239
Cdd:PRK09393  209 PRPVASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQ 288

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1382703435 240 VAAAVGLTDQPHLTRAFTRRYGITPARYQKQVAR 273
Cdd:PRK09393  289 IAERAGFGSEESLRHHFRRRAATSPAAYRKRFGR 322
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 158-274 5.29e-22

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 93.30  E-value: 5.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 158 YARHAPQAAEGAHRFDRVREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAG-LP 236
Cdd:COG4977   198 FSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLS 277

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1382703435 237 AADVAAAVGLTDQPHLTRAFTRRYGITPARYQKQVARQ 274
Cdd:COG4977   278 IEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
186-267 1.29e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.45  E-value: 1.29e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  186 PLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAG-LPAADVAAAVGLTDQPHLTRAFTRRYGITP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 1382703435  265 ARY 267
Cdd:smart00342  81 SEY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 2.14e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 87.91  E-value: 2.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  16 RFRQLPALPGVELYHAHIAHYAFEPHTHEAFGIGAIELGAERFRYRGAQHVAAVNSLVTMNPDELHTGEAATQQGWRYRM 95
Cdd:COG2207     2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  96 IYLEPETLAQLTGERHWWFAEVERHDPLRARQTGQLIAALWSAPDTLAQQGLLLDLIDTFRPYARHAPQAAEGAHRFDRV 175
Cdd:COG2207    82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 176 REFLyenyMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAG-LPAADVAAAVGLTDQPHLTR 254
Cdd:COG2207   162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                         250       260
                  ....*....|....*....|
gi 1382703435 255 AFTRRYGITPARYQKQVARQ 274
Cdd:COG2207   238 AFKKRFGVTPSEYRKRLRAR 257
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 23-152 4.11e-20

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 84.02  E-value: 4.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435  23 LPGVELYHAHIAHYAFEPHTHEAFGIGAIELGAERFRYRGAQHVAAVNSLVTMNPDELHTGEAATQQGWRYRMIYLEPET 102
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1382703435 103 LAQLTGERHW--WFAEVERHDPLRARQTGQLIAALWSA--PDTLAQQGLLLDLI 152
Cdd:pfam02311  81 LERILADISIlaGGPLPLLRDPELAALLRALFRLLEEAgrSDDLLAEALLYQLL 134
HTH_18 pfam12833
Helix-turn-helix domain;
192-270 1.28e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.10  E-value: 1.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 192 IAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLA--AGLPAADVAAAVGLTDQPHLTRAFTRRYGITPARYQK 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLedTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1382703435 270 Q 270
Cdd:pfam12833  81 R 81
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 162-285 3.96e-19

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 85.88  E-value: 3.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 162 APQAAEGAHRFDRVREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLAAGLPAADVA 241
Cdd:COG2169    76 APGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAA 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1382703435 242 AAVGLTDQPHLTRAFTRRYGITPARYQKQVARQIFSPAIIQTPL 285
Cdd:COG2169   156 YAAGFGSLSRFYEAFKKLLGMTPSAYRRGGAGAAIRFAPTPCSL 199
ftrA PRK09393
transcriptional activator FtrA; Provisional
 161-273 3.50e-14

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 71.53  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 161 HAPQAAEGAHRFDRVREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFL-AAGLPAAD 239
Cdd:PRK09393  209 PRPVASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQ 288

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1382703435 240 VAAAVGLTDQPHLTRAFTRRYGITPARYQKQVAR 273
Cdd:PRK09393  289 IAERAGFGSEESLRHHFRRRAATSPAAYRKRFGR 322
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
155-269 3.63e-10

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 59.81  E-value: 3.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 155 FRPYARHAPQAAEG-AHRFDRVREF--LYENYMlPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFL 231
Cdd:PRK15435   66 FRPCKRCQPDKANPqQHRLDKITHAcrLLEQET-PVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREAL 144

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1382703435 232 AAGLPAADVAAAVGLTDQPHLTRAFTRRYGITPARYQK 269
Cdd:PRK15435  145 AKGESVTTSILNAGFPDSSSYYRKADETLGMTAKQFRH 182
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 181-219 8.66e-08

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 47.53  E-value: 8.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1382703435 181 ENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQML 219
Cdd:pfam00165   3 ENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYR 41
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
186-269 1.31e-07

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 51.55  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 186 PLTLDEIAAEAALSPYHFQRQFKaryDVTPHQM---LMAVRLWRAkqflAAGL-----PAADVAAAVGLTDQPHLTRAFT 257
Cdd:PRK15121   21 PLSLDNVAAKAGYSKWHLQRMFK---DVTGHAIgayIRARRLSKA----AVALrltsrPILDIALQYRFDSQQTFTRAFK 93

                          90
                  ....*....|..
gi 1382703435 258 RRYGITPARYQK 269
Cdd:PRK15121   94 KQFAQTPALYRR 105
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
177-271 2.00e-06

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 45.69  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 177 EFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFL-AAGLPAADVAAAVGLTDQPHLTRA 255
Cdd:PRK10219   12 AWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELrTTERPIFDIAMDLGYVSQQTFSRV 91

                          90
                  ....*....|....*.
gi 1382703435 256 FTRRYGITPARYQKQV 271
Cdd:PRK10219   92 FRRQFDRTPSDYRHRL 107
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
174-270 1.18e-05

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 45.73  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 174 RVRE---FLYENYMLPLTLDEIAAEAALSPYHFQRQFKarydvtpHQMLMAVRLWR-------AKQFL-AAGLPAADVAA 242
Cdd:PRK10572  184 RVREacqYISDHLASEFDIESVAQHVCLSPSRLAHLFR-------QQLGISVLRWRedqrisrAKLLLqTTRMPIATIGR 256

                          90       100
                  ....*....|....*....|....*...
gi 1382703435 243 AVGLTDQPHLTRAFTRRYGITPARYQKQ 270
Cdd:PRK10572  257 NVGYDDQLYFSRVFKKCTGASPSEFRAR 284
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
186-268 1.96e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 45.48  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 186 PLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLA-AGLPAADVAAAVGLTDQPHLTRAFTRRYGITP 264
Cdd:PRK13500  222 PFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQhSRLLISDISTECGFEDSNYFSVVFTRETGMTP 301


                  ....
gi 1382703435 265 ARYQ 268
Cdd:PRK13500  302 SQWR 305
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
175-268 7.62e-05

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 41.63  E-value: 7.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 175 VREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWR-AKQFLAAGLPAADVAAAVGLTDQPHLT 253
Cdd:PRK11511   14 ILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEiAQKLKESNEPILYLAERYGFESQQTLT 93

                          90
                  ....*....|....*
gi 1382703435 254 RAFTRRYGITPARYQ 268
Cdd:PRK11511   94 RTFKNYFDVPPHKYR 108
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 145-270 1.81e-04

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 42.33  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 145 QGLLLDLIDTFRPYARHAPQAAEGAHR-FDRVREFLYENYMLP-LTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAv 222
Cdd:PRK09685  171 EALLEALIALLRPALHQRESVQPRRERqFQKVVALIDQSIQEEiLRPEWIAGELGISVRSLYRLFAEQGLVVAQYIRNR- 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1382703435 223 RLWRAKQFL---AAGLPAADVAAAVGLTDQPHLTRAFTRRYGITPARYQKQ 270
Cdd:PRK09685  250 RLDRCADDLrpaADDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRK 300
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
172-268 3.82e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 41.19  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 172 FDRVREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLA-AGLPAADVAAAVGLTDQP 250
Cdd:PRK13502  178 LDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQhSPLMISEISMQCGFEDSN 257

                          90
                  ....*....|....*...
gi 1382703435 251 HLTRAFTRRYGITPARYQ 268
Cdd:PRK13502  258 YFSVVFTRETGMTPSQWR 275
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 188-274 9.98e-04

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 39.91  E-value: 9.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 188 TLDEIAAEAALSPYHFQRQFKARyDVTPHQMLMAVRLWRAKQFLAA-GLPAADVAAAVGLTDQPHLTRAFTRRYGITPAR 266
Cdd:PRK09978  160 TLARIASELLMSPSLLKKKLREE-ETSYSQLLTECRMQRALQLIVIhGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTE 238


                  ....*...
gi 1382703435 267 YQKQVARQ 274
Cdd:PRK09978  239 YQERSAQG 246
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
147-279 1.59e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 39.50  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 147 LLLDLIDTFRPY---ARHAPQAAEGaHRFDRVREFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVR 223
Cdd:PRK13501  151 LLLQLAIVLKRHryrAEQAHLLPDG-EQLDLIMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIR 229

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1382703435 224 LWRAKQFL-AAGLPAADVAAAVGLTDQPHLTRAFTRRYGITPARYQKQVARQIFSPA 279
Cdd:PRK13501  230 LCHAKCLLrGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRFIRSPVLPA 286
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 238-269 1.76e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.59  E-value: 1.76e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1382703435 238 ADVAAAVGLtDQPHLTRAFTRRYGITPARYQK 269
Cdd:pfam00165  12 ADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK10371 PRK10371
transcriptional regulator MelR;
177-278 8.02e-03

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 37.11  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382703435 177 EFLYENYMLPLTLDEIAAEAALSPYHFQRQFKARYDVTPHQMLMAVRLWRAKQFLA-AGLPAADVAAAVGLTDQPHLTRA 255
Cdd:PRK10371  198 GFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSdTDKSILDIALTAGFRSSSRFYST 277

                          90       100
                  ....*....|....*....|....*
gi 1382703435 256 FTRRYGITPARYQK--QVARQIFSP 278
Cdd:PRK10371  278 FGKYVGMSPQQYRKlsQQRRQTFPG 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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