|
Name |
Accession |
Description |
Interval |
E-value |
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
45-385 |
4.91e-88 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 269.22 E-value: 4.91e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 45 KPLIILGIVVVIMVIGAIIWWF--MTRNLETTDDAFIEGDAVTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDATAQ 122
Cdd:COG1566 5 KKRRLLALVLLLLALGLALWAAgrNGPDEPVTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 123 RDQAQAQLSLAESQLHQAQAQLALakvqyPAQRDQAKAQVLRAQAELANARAEYQRQRG-VDPRATSKQNIDAANAQLRS 201
Cdd:COG1566 85 LAQAEAQLAAAEAQLARLEAELGA-----EAEIAAAEAQLAAAQAQLDLAQRELERYQAlYKKGAVSQQELDEARAALDA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 202 AEAGLANAQAQLEVAEQvqlQIRQQETNVEArQSQVEQARAQLKTAELNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSAL 281
Cdd:COG1566 160 AQAQLEAAQAQLAQAQA---GLREEEELAAA-QAQVAQAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 282 FSIVSPD-IWVVANFKESQLERMRPGNKVEISVDAFPDLELEGHVESIQQGSGsrfSAFPAENATGNfvkIVQRVPVKIV 360
Cdd:COG1566 236 LTIVPLDdLWVEAYVPETDLGRVKPGQPVEVRVDAYPDRVFEGKVTSISPGAG---FTSPPKNATGN---VVQRYPVRIR 309
|
330 340
....*....|....*....|....*
gi 1382722093 361 IDKGLENwnqPLPLGLSVEPEVTVE 385
Cdd:COG1566 310 LDNPDPE---PLRPGMSATVEIDTE 331
|
|
| 8a0101 |
TIGR00998 |
efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, ... |
44-382 |
8.98e-81 |
|
efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, Other]
Pssm-ID: 273385 [Multi-domain] Cd Length: 334 Bit Score: 250.87 E-value: 8.98e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 44 KKPLIILGIVVVIMVIGAI-IWWFMT-RNLETTDDAFIEGDAVTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDATA 121
Cdd:TIGR00998 1 RKYFLLLLVVLLIVVAGAYaIYWFLVlRDYESTDDAYVKANQLQVSSQVSGSVIEVNVDDTDYVKQGDVLVRLDPTNAEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 122 QRDQAQAQLSLAESQLHQAQAQLAlakvQYPAQRDQAKAQVLRAQAELANARAEYQR-----QRGVDPRATSKQNIDAan 196
Cdd:TIGR00998 81 ALAKAEANLAALVRQTKQLEITVQ----QLQAKVESLKIKLEQAREKLLQAELDLRRrvplfKKGLISREELDHARKA-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 197 aqlrsaeagLANAQAQLEVAEQVQLQIRQQETNVEA--RQSQVEQARAQLKTAELNLSYTEVRAPFDGYVTKRNVQNGML 274
Cdd:TIGR00998 155 ---------LLSAKAALNAAIQEQLNANQALVRGTPlkKQPAVQEAKERLKTAWLALKRTVIRAPFDGYVARRFVQVGQV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 275 VQAGSALFSIVSPD-IWVVANFKESQLERMRPGNKVEISVDAFP-DLELEGHVESIQQGSGSRFSAFPAENATGNFVKIV 352
Cdd:TIGR00998 226 VSPGQPLMAVVPAEqMYVEANFKETQLKNVRIGQPVTIRSDLYGsDVVFEGKVTGISMGTGSAFSLLPAQNATGNWIKVV 305
|
330 340 350
....*....|....*....|....*....|
gi 1382722093 353 QRVPVKIVIDKGlENWNQPLPLGLSVEPEV 382
Cdd:TIGR00998 306 QRLPVRIKLDPK-ELDEHPLRIGLSAEVEI 334
|
|
| PRK15136 |
PRK15136 |
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA; |
39-382 |
3.13e-59 |
|
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
Pssm-ID: 185090 [Multi-domain] Cd Length: 390 Bit Score: 196.84 E-value: 3.13e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 39 RKRPGKKPLIILGIVVVIMVIGAIIWWFMT-RNLETTDDAFIEGDAVTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPR 117
Cdd:PRK15136 16 KKGKRKRALLLLTLLFIIIGVAYGIYWFLVlRHHQETDDAYVAGNQVQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPT 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 118 DATAQRDQAQAQLSLAESQLHQaqaQLALAKvqypaqrdQAKAQVLRAQAELANARAEYQRqrgvdpratsKQNIDAANA 197
Cdd:PRK15136 96 DAEQAFEKAKTALANSVRQTHQ---LMINSK--------QYQANIELQKTALAQAQSDLNR----------RVPLGNANL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 198 ----QLRSAEAGLANAQAQLEVAEQvQLQIRQQ---ETNVEaRQSQVEQARAQLKTAELNLSYTEVRAPFDGYVTKRNVQ 270
Cdd:PRK15136 155 igreELQHARDAVASAQAQLDVAIQ-QYNANQAmilNTPLE-DQPAVQQAATEVRNAWLALQRTKIVSPMTGYVSRRSVQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 271 NGMLVQAGSALFSIV-SPDIWVVANFKESQLERMRPGNKVEISVDAF-PDLELEGHVESIQQGSGSRFSAFPAENATGNF 348
Cdd:PRK15136 233 VGAQISPTTPLMAVVpATNLWVDANFKETQLANMRIGQPATITSDIYgDDVVYTGKVVGLDMGTGSAFSLLPAQNATGNW 312
|
330 340 350
....*....|....*....|....*....|....*
gi 1382722093 349 VKIVQRVPVKIVID-KGLEnwNQPLPLGLSVEPEV 382
Cdd:PRK15136 313 IKVVQRLPVRIELDaKQLA--QHPLRIGLSTLVTV 345
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
38-363 |
2.59e-57 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 190.62 E-value: 2.59e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 38 TRKRPGKKPLIILGIVVVIMVIGAIIWWFMTRNLeTTDDAFIEGDAVTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPR 117
Cdd:PRK10476 4 TPKKSPRKKLPALAIVALAIVALVFVIWRTDSAP-STDDAYIDADVVHVASEVGGRIVELAVTENQAVKKGDLLFRIDPR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 118 DATAQRDQAQAQLSLaesqlhqAQAQLALAKVQYPAQR---DQAKAQVLRAQAELANARAEYQRQRGVDPRA-TSKQNID 193
Cdd:PRK10476 83 PYELTVAQAQADLAL-------ADAQIMTTQRSVDAERsnaASANEQVERARANAKLATRTLERLEPLLAKGyVSAQQVD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 194 AANAQLRSAEAGLANAQAQlevaeqvQLQIRQQETNVEARQSQVEQARAQLKTAELNLSYTEVRAPFDGYVTKRNVQNGM 273
Cdd:PRK10476 156 QARTAQRDAEVSLNQALLQ-------AQAAAAAVGGVDALVAQRAAREAALAIAELHLEDTTVRAPFDGRVVGLKVSVGE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 274 LVQAGSALFSIVSPDIW-VVANFKESQLERMRPGNKVEISVDAFPDLELEGHVESIQQG-----SGSRFSAFPAENATGN 347
Cdd:PRK10476 229 FAAPMQPIFTLIDTDHWyAIANFRETDLKNIRVGDCATVYSMIDRGRPFEGKVDSIGWGvlpddGGNVPRGLPYVPRSIN 308
|
330
....*....|....*.
gi 1382722093 348 FVKIVQRVPVKIVIDK 363
Cdd:PRK10476 309 WVRVAQRFPVRIMLDK 324
|
|
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
84-328 |
5.67e-47 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 162.81 E-value: 5.67e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 84 VTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDATAQRDQAQAQLslaesqlhqaqaqlalakvqypaqrdqakaqvL 163
Cdd:COG0845 24 VEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQL--------------------------------A 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 164 RAQAELANARAEYQRQRG-VDPRATSKQNIDAANAQLRSAEAglanaqaqlevaeqvqlqirqqetnvearqsQVEQARA 242
Cdd:COG0845 72 AAQAQLELAKAELERYKAlLKKGAVSQQELDQAKAALDQAQA-------------------------------ALAAAQA 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 243 QLKTAELNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSALFSIVSPD-IWVVANFKESQLERMRPGNKVEISVDAFPDLEL 321
Cdd:COG0845 121 ALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGTPLFTIADLDpLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTF 200
|
....*..
gi 1382722093 322 EGHVESI 328
Cdd:COG0845 201 EGKVTFI 207
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
68-335 |
1.04e-46 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 162.21 E-value: 1.04e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 68 TRNLETTDDAFIEGDAVTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDATAQRDQAQAQLSLAESQLHQAQAQLALA 147
Cdd:pfam00529 5 TKGVEAPGRVVVSGNAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELDRL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 148 KV-------------QYPAQRDQAKAQVLRAQAELANARAEYQRQRGVDPR-ATSKQNIDAANAQLRSAEAGLANAQAQL 213
Cdd:pfam00529 85 QAleselaisrqdydGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIgGISRESLVTAGALVAQAQANLLATVAQL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 214 -----EVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNLSYTEVRAPFDGYVTKRNVQ-NGMLVQAGSALFSIVSP 287
Cdd:pfam00529 165 dqiyvQITQSAAENQAEVRSELSGAQLQIAEAEAELKLAKLDLERTEIRAPVDGTVAFLSVTvDGGTVSAGLRLMFVVPE 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1382722093 288 D-IWVVANFKESQLERMRPGNKVEISVDAFPD---LELEGHVESIQQGSGSR 335
Cdd:pfam00529 245 DnLLVPGMFVETQLDQVRVGQPVLIPFDAFPQtktGRFTGVVVGISPDTGPV 296
|
|
| PRK03598 |
PRK03598 |
putative efflux pump membrane fusion protein; Provisional |
44-325 |
6.76e-38 |
|
putative efflux pump membrane fusion protein; Provisional
Pssm-ID: 235136 [Multi-domain] Cd Length: 331 Bit Score: 138.94 E-value: 6.76e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 44 KKPLIILGIVVVIMVIGAIIWWFMTRNLETTDDAFIEGDAVTV--APKVAGYVTELRVKDNQRVKKGDLLVVIDprDATA 121
Cdd:PRK03598 2 KKKVVIGLAVVVLAAAVAGGWWWYQSRQDNGLTLYGNVDIRTVnlGFRVGGRLASLAVDEGDAVKAGQVLGELD--AAPY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 122 QRDQAQAQLSLAEsqlhqAQAQLALAKVQY-PAQRDQAKAQVLRAQAELANARAEYQRQRGVDP-RATSKQNIDAANAQL 199
Cdd:PRK03598 80 ENALMQAKANVSV-----AQAQLDLMLAGYrDEEIAQARAAVKQAQAAYDYAQNFYNRQQGLWKsRTISANDLENARSSR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 200 RSAEAGLANAQAQLEvaeQVQLQIRQQEtnVEARQSQVEQARAQLKTAELNLSYTEVRAPFDGYVTKRNVQNGMLVQAGS 279
Cdd:PRK03598 155 DQAQATLKSAQDKLS---QYREGNRPQD--IAQAKASLAQAQAALAQAELNLQDTELIAPSDGTILTRAVEPGTMLNAGS 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1382722093 280 ALF--SIVSPdIWVVANFKESQLERMRPGNKVEISVDAFPDLELEGHV 325
Cdd:PRK03598 230 TVFtlSLTRP-VWVRAYVDERNLGQAQPGRKVLLYTDGRPDKPYHGQI 276
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
81-328 |
5.59e-35 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 130.90 E-value: 5.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 81 GDAVTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDATAQRDQAQAQLSLAESQLHQAQAQLAlakvqypaqrdqaKA 160
Cdd:TIGR01730 24 VDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQLELAQRSFE-------------RA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 161 QVLRAQAelanaraeyqrqrgvdprATSKQNIDAANAQLRSAEAglanaqaqlevaeqvqlqirqqetnvearqsQVEQA 240
Cdd:TIGR01730 91 ERLVKRN------------------AVSQADLDDAKAAVEAAQA-------------------------------DLEAA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 241 RAQLKTAELNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSALFSIVSPD-IWVVANFKESQLERMRPGNKVEISVDAFPDL 319
Cdd:TIGR01730 122 KASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQTLATIVDLDpLEADFSVPERDLPQLRRGQTLTVELDALPGE 201
|
....*....
gi 1382722093 320 ELEGHVESI 328
Cdd:TIGR01730 202 EFKGKLRFI 210
|
|
| PRK10559 |
PRK10559 |
p-hydroxybenzoic acid efflux pump subunit AaeA; |
52-375 |
6.06e-32 |
|
p-hydroxybenzoic acid efflux pump subunit AaeA;
Pssm-ID: 182548 [Multi-domain] Cd Length: 310 Bit Score: 122.54 E-value: 6.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 52 IVVVIMVIGAI--IWWFMTRNLETTDDAFiEGDAVTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDprdataqrdqaqaq 129
Cdd:PRK10559 15 LVLVILAFIAIfrAWVFYTESPWTRDARF-SADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTID-------------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 130 lslaesqlhQAQAQLALakvqypaqrDQAKAQVLRAQAELANARAEYQRQRGVDPRATSKQNIDAANAQLRSAEAGLANA 209
Cdd:PRK10559 80 ---------QPRYQKAL---------AEAEADVAYYQVLAQEKRREAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 210 QAQLEVaeqvqlqirqqetnvearqsqveqaraqlktAELNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSALFSIVSPD- 288
Cdd:PRK10559 142 QATRDL-------------------------------AKLDLERTVIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNs 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 289 IWVVANFKESQLERMRPGNKVEISvdafP---DLELEGHVESIQQG----SGSRFSAFPAE-NATGNFVKIVQRVPVKIV 360
Cdd:PRK10559 191 FYVLAYMEETKLEGVRPGYRAEIT----PlgsNKVLKGTVDSVAAGvtnsSSTRDSKGMATiDSNLEWVRLAQRVPVRIR 266
|
330
....*....|....*
gi 1382722093 361 IDkglENWNQPLPLG 375
Cdd:PRK10559 267 LD---NQQGNLYPAG 278
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
77-328 |
9.88e-20 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 86.79 E-value: 9.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 77 AFIEGDAVTVAPKVAGYVTELRVKDN-QRVKKGDLLVVID-Prdataqrdqaqaqlslaesqlhqaqaqlalakvqypaq 154
Cdd:pfam16576 13 AYDERRLAHVHARVEGWIEKLYVNATgDPVKKGQPLAELYsP-------------------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 155 rdqakaqvlraqaELANARAEYQRQRGVDPRATSKQNIDAANAQLRSAeaGLANAQ-AQLEVAEQVQlqirqqetnvear 233
Cdd:pfam16576 55 -------------ELVAAQQEYLLALRSGDALSKSELLRAARQRLRLL--GMPEAQiAELERTGKVQ------------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 234 qsqveqaraqlktaelnlSYTEVRAPFDGYVTKRNVQNGMLVQAGSALFSIVSPD-IWVVANFKESQLERMRPGNKVEIS 312
Cdd:pfam16576 107 ------------------PTVTVYAPISGVVTELNVREGMYVQPGDTLFTIADLStVWVEADVPEQDLALVKVGQPAEVT 168
|
250
....*....|....*.
gi 1382722093 313 VDAFPDLELEGHVESI 328
Cdd:pfam16576 169 LPALPGKTFEGKVDYI 184
|
|
| type_I_hlyD |
TIGR01843 |
type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport ... |
45-384 |
2.15e-18 |
|
type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 130902 [Multi-domain] Cd Length: 423 Bit Score: 86.22 E-value: 2.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 45 KPLIILGIVVVI-MVIGAIIWWFMTrNLE----TTDDAFIEGDAVTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDA 119
Cdd:TIGR01843 1 SRFARLITWLIAgLVVIFFLWAYFA-PLDvvatATGKVVPSGNVKVVQHLEGGIVREILVREGDRVKAGQVLVELDATDV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 120 TAQRDQAQAQLS-------------------------------LAESQLHQAQAQLALAKVQYPAQRDQAKAQVLRAQAE 168
Cdd:TIGR01843 80 EADAAELESQVLrleaevarlraeadsqaaiefpddllsaedpAVPELIKGQQSLFESRKSTLRAQLELILAQIKQLEAE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 169 LANARAE---YQRQRGV------------DPRATSKQNIDAANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEAR 233
Cdd:TIGR01843 160 LAGLQAQlqaLRQQLEViseelearrklkEKGLVSRLELLELERERAEAQGELGRLEAELEVLKRQIDELQLERQQIEQT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 234 ------------QSQVEQARAQLKTAELNLSYTEVRAPFDGYV-TKRNVQNGMLVQAGSALFSIV--SPDIWVVANFKES 298
Cdd:TIGR01843 240 freevleelteaQARLAELRERLNKARDRLQRLIIRSPVDGTVqSLKVHTVGGVVQPGETLMEIVpeDDPLEIEAKLSPK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 299 QLERMRPGNKVEISVDAFPDLE---LEGHVESIQQgsgsrfSAFPAENATGNFVKIVQRVPVKIVIDKGLenwNQPLPLG 375
Cdd:TIGR01843 320 DIGFVHVGQPAEIKFSAFPYRRygiLNGKVKSISP------DTFTDERGGGPYYRVRISIDQNTLGIGPK---GLELSPG 390
|
....*....
gi 1382722093 376 LSVEPEVTV 384
Cdd:TIGR01843 391 MPVTADIKT 399
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
84-329 |
3.68e-16 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 79.05 E-value: 3.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 84 VTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDATAQRDQAQAQLSLAESQLHQAQAQLALAKVQYPAQRDQAKAQvl 163
Cdd:PRK11578 62 VDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAENQIKEVEATLMELRAQRQQAEAELKLARVTLSRQQRLAKTQ-- 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 164 raqaelanaraeyqrqrgvdprATSKQNIDaanaqlrSAEAGLANAQAQlevaeqvqlqirqqetnVEARQSQVEQARAQ 243
Cdd:PRK11578 140 ----------------------AVSQQDLD-------TAATELAVKQAQ-----------------IGTIDAQIKRNQAS 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 244 LKTAELNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSALFSIVS----PDIWVVANFKESQLERMRPGNKVEISVDAFPDL 319
Cdd:PRK11578 174 LDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTladmSTMLVKAQVSEADVIHLKPGQKAWFTVLGDPLT 253
|
250
....*....|
gi 1382722093 320 ELEGHVESIQ 329
Cdd:PRK11578 254 RYEGVLKDIL 263
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
255-342 |
9.16e-13 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 63.92 E-value: 9.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 255 EVRAPFDGYVTKRNVQNGMLVQAGSALFSIVSPD-IWVVANFKESQLERMRPGNKVEISVDAFPDLELEGHVESIQQGSG 333
Cdd:pfam13437 1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDrLLVEAFVPAADLGSLKKGQKVTLKLDPGSDYTLEGKVVRISPTVD 80
|
....*....
gi 1382722093 334 SRFSAFPAE 342
Cdd:pfam13437 81 PDTGVIPVR 89
|
|
| Biotin_lipoyl_2 |
pfam13533 |
Biotin-lipoyl like; |
84-131 |
2.48e-10 |
|
Biotin-lipoyl like;
Pssm-ID: 433286 Cd Length: 50 Bit Score: 55.53 E-value: 2.48e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1382722093 84 VTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDATAQRDQAQAQLS 131
Cdd:pfam13533 3 VKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEAQLA 50
|
|
| 8a0102 |
TIGR00999 |
Membrane Fusion Protein cluster 2 (function with RND porters); [Transport and binding proteins, ... |
146-313 |
4.13e-10 |
|
Membrane Fusion Protein cluster 2 (function with RND porters); [Transport and binding proteins, Other]
Pssm-ID: 273386 [Multi-domain] Cd Length: 265 Bit Score: 59.76 E-value: 4.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 146 LAKVqYPAQRDQAKAQVLRAQAELANARAEYQR-----QRGVdpraTSKQNIDAANAQLRSAEAGLANAQAQLEVAEQVQ 220
Cdd:TIGR00999 10 LAVV-DSPELAKMAAELKVAQKRVELARKTYERekklfEQGV----IPRQEFESAEYALEEAQAEVQAAKSELRSAREAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 221 lqirqqetnvearqsqveqaraqlktaelNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSALFSIVS-PDIWVVANFKESQ 299
Cdd:TIGR00999 85 -----------------------------DGSYVEVRSPFDGYITQKSVTLGDYVAPQAELFRVADlGAVWVEAEVPAKD 135
|
170
....*....|....
gi 1382722093 300 LERMRPGNKVEISV 313
Cdd:TIGR00999 136 VSRIRKGSKATVLL 149
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
84-280 |
5.62e-10 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 60.57 E-value: 5.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 84 VTVAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRdataqrdqaQAQLSLAesqlhQAQAQLAlakvqypaqrdqakaqvl 163
Cdd:PRK11556 88 VTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPR---------PFKVALA-----QAQGQLA------------------ 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 164 RAQAELANARAEYQR-QRGVDPRATSKQNIDaanaqlrsaeaglanAQAQLevaeqvqlqIRQQETNVEARQSQVEQARa 242
Cdd:PRK11556 136 KDQATLANARRDLARyQQLAKTNLVSRQELD---------------AQQAL---------VSETEGTIKADEASVASAQ- 190
|
170 180 190
....*....|....*....|....*....|....*...
gi 1382722093 243 qlktaeLNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSA 280
Cdd:PRK11556 191 ------LQLDYSRITAPISGRVGLKQVDVGNQISSGDT 222
|
|
| PRK09578 |
PRK09578 |
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit; |
86-173 |
1.96e-09 |
|
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 169982 [Multi-domain] Cd Length: 385 Bit Score: 58.65 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 86 VAPKVAGYVTELRVKDNQRVKKGDLLVVIDPRDATAQRDQAQAQLSLAESQLHQAQAQLA----LAKVQYPAQRD----- 156
Cdd:PRK09578 66 VRARVAGIVTARTYEEGQEVKQGAVLFRIDPAPLKAARDAAAGALAKAEAAHLAALDKRRryddLVRDRAVSERDyteav 145
|
90 100
....*....|....*....|.
gi 1382722093 157 ----QAKAQVLRAQAELANAR 173
Cdd:PRK09578 146 aderQAKAAVASAKAELARAQ 166
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
97-249 |
6.66e-09 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 57.64 E-value: 6.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 97 LRVKDNQRVKKGDLLVVIDpRDATAQRDQAQAQLSLAESQLHQAQAQLALAKvqypAQRDQAKAQVLRAQAELANARAEY 176
Cdd:COG1196 216 RELKEELKELEAELLLLKL-RELEAELEELEAELEELEAELEELEAELAELE----AELEELRLELEELELELEEAQAEE 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 177 QR--------QRGVDP----RATSKQNIDAANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQL 244
Cdd:COG1196 291 YEllaelarlEQDIARleerRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370
|
....*
gi 1382722093 245 KTAEL 249
Cdd:COG1196 371 EAELA 375
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
118-287 |
1.22e-08 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 56.95 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 118 DATAQRDQAQAQLSLAESQLHQAQAQLALAKVQYPAQRD-----QAKAQVLRAQAELANARAEYQRQrgvDPRATS-KQN 191
Cdd:COG3206 223 ELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQspviqQLRAQLAELEAELAELSARYTPN---HPDVIAlRAQ 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 192 IDAANAQLRS-AEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLktAELNLSYTEVRAPFDGYVTKRNvQ 270
Cdd:COG3206 300 IAALRAQLQQeAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAEL--RRLEREVEVARELYESLLQRLE-E 376
|
170
....*....|....*..
gi 1382722093 271 NGMLVQAGSALFSIVSP 287
Cdd:COG3206 377 ARLAEALTVGNVRVIDP 393
|
|
| KpsE |
COG3524 |
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; |
153-281 |
1.96e-08 |
|
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442746 [Multi-domain] Cd Length: 370 Bit Score: 55.63 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 153 AQRDQ---AKAQVLRAQAELANARA---EYQRQRG-VDPRATSKqnidAANAQLRSAEAGLANAQAQLEVAEQV----QL 221
Cdd:COG3524 174 AREDAvrfAEEEVERAEERLRDAREallAFRNRNGiLDPEATAE----ALLQLIATLEGQLAELEAELAALRSYlspnSP 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 222 QIRQQETNVEARQSQVEQARAQLKTAELNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSAL 281
Cdd:COG3524 250 QVRQLRRRIAALEKQIAAERARLTGASGGDSLASLLAEYERLELEREFAEKAYTSALAAL 309
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
118-263 |
1.57e-07 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 53.38 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 118 DATAQRDQAQAQLSLAESQLHQAQAQLALAKVQYPAQRDQAKA------------QVLRAQAELANARAEYQRqrgvdpr 185
Cdd:COG4913 607 DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREAlqrlaeyswdeiDVASAEREIAELEAELER------- 679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 186 atskqnIDAANAQLRSAEAGLANAQAQLEVAEQ----VQLQIRQQETNVEARQSQVEQARAQLKTAElNLSYTEVRAPFD 261
Cdd:COG4913 680 ------LDASSDDLAALEEQLEELEAELEELEEeldeLKGEIGRLEKELEQAEEELDELQDRLEAAE-DLARLELRALLE 752
|
..
gi 1382722093 262 GY 263
Cdd:COG4913 753 ER 754
|
|
| YqiK |
COG2268 |
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]; |
119-245 |
3.10e-07 |
|
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 52.18 E-value: 3.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 119 ATAQRDQAQAQlSLAESQLHQAQAQLALAKVQYPAQRDQAKAQVLRAQAELANARAEYQRQRgvdpratskqniDAANAQ 198
Cdd:COG2268 197 IIRDARIAEAE-AERETEIAIAQANREAEEAELEQEREIETARIAEAEAELAKKKAEERREA------------ETARAE 263
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1382722093 199 lRSAEAGLANAQAQLEVaeQVQLQIRQQETNVEARQSQVEQARAQLK 245
Cdd:COG2268 264 -AEAAYEIAEANAEREV--QRQLEIAEREREIELQEKEAEREEAELE 307
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
117-251 |
5.09e-07 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 51.86 E-value: 5.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 117 RDATAQRDQAQAQLSLAESQLHQAQ---AQLALAKVQYPAQRDQAKAQVLRAQAELANARAEYQRQRGVdpRATSKQNID 193
Cdd:COG1196 291 YELLAELARLEQDIARLEERRRELEerlEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE--LAEAEEALL 368
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1382722093 194 AANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNL 251
Cdd:COG1196 369 EAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
117-251 |
6.39e-07 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 51.48 E-value: 6.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 117 RDATAQRDQAQAQLSLAEsqLHQAQAQLALAKvqypAQRDQAKAQVLRAQAELANARAEYQRQRGVdpRATSKQNIDAAN 196
Cdd:COG1196 216 RELKEELKELEAELLLLK--LRELEAELEELE----AELEELEAELEELEAELAELEAELEELRLE--LEELELELEEAQ 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1382722093 197 AQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNL 251
Cdd:COG1196 288 AEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEEL 342
|
|
| TolC |
COG1538 |
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; |
129-252 |
1.51e-06 |
|
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441147 [Multi-domain] Cd Length: 367 Bit Score: 49.65 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 129 QLSLAESQLHQAQAQLALAKVQY------------PAQRDQAKAQVLRAQAELANARAEYQRQ--RGVDPRATSKQNIDA 194
Cdd:COG1538 15 DLRAARARVEAARAQLRQARAGLlpsqeldlggkrRARIEAAKAQAEAAEADLRAARLDLAAEvaQAYFDLLAAQEQLAL 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1382722093 195 ANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNLS 252
Cdd:COG1538 95 AEENLALAEELLELARARYEAGLASRLDVLQAEAQLAQARAQLAQAEAQLAQARNALA 152
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
86-280 |
1.78e-06 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 49.71 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 86 VAPKVAGYVTELRVKDNQRVKKGDLLVVIDPrdataqrdqaqaqlslaesqlhqaqaqlalAKVQypAQRDQAKAQVLRA 165
Cdd:PRK09859 64 IRPQVGGIIIKRNFIEGDKVNQGDSLYQIDP------------------------------APLQ--AELNSAKGSLAKA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 166 QAELANARAEYQRQRGV-DPRATSKQNIDAANAQLRSAEAglanaqaqlevaeqvqlqirqqetNVEARQSQVEQAraql 244
Cdd:PRK09859 112 LSTASNARITFNRQASLlKTNYVSRQDYDTARTQLNEAEA------------------------NVTVAKAAVEQA---- 163
|
170 180 190
....*....|....*....|....*....|....*.
gi 1382722093 245 ktaELNLSYTEVRAPFDGYVTKRNVQNGMLVQAGSA 280
Cdd:PRK09859 164 ---TINLQYANVTSPITGVSGKSSVTVGALVTANQA 196
|
|
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
182-280 |
2.16e-06 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 49.33 E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 182 VDPrATSKQNIDAANAQLRSAEAglANAQAQLEVAEQVQL----QIRQQETN---VEARQSQ--VEQARAQLKTAELNLS 252
Cdd:PRK15030 96 IDP-ATYQATYDSAKGDLAKAQA--AANIAQLTVNRYQKLlgtqYISKQEYDqalADAQQANaaVTAAKAAVETARINLA 172
|
90 100
....*....|....*....|....*...
gi 1382722093 253 YTEVRAPFDGYVTKRNVQNGMLVQAGSA 280
Cdd:PRK15030 173 YTKVTSPISGRIGKSNVTEGALVQNGQA 200
|
|
| type_I_sec_TolC |
TIGR01844 |
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ... |
122-254 |
5.36e-06 |
|
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]
Pssm-ID: 273829 [Multi-domain] Cd Length: 415 Bit Score: 48.14 E-value: 5.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 122 QRDQAQAQLSLAESQLHQAQAQLALAK-------------VQYPAQRDQAKAQVLRAQAELANARAEYQRQRGVDPRAts 188
Cdd:TIGR01844 121 EVLRAQEILALAEANLAALKEQLDLARarfdvglgtrtdvLQAEARYASARAQLIQAQNNLDDAKAQLRRLVGQPELA-- 198
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1382722093 189 KQNIDAANAQLrsaeagLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQ-LKTAELNLSYT 254
Cdd:TIGR01844 199 PLAVPSFPAEL------PEPLDQLLEIAEASNPLLLAAQAAVDAARYQVEQARAGhLPTLSLTASTG 259
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
119-250 |
1.59e-05 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 47.22 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 119 ATAQRDQAQAQLSLAESQLHQAQAQLALAKvqypAQRDQAKAQVL--------RAQAELANARAEYQRQRgvDPRATSKQ 190
Cdd:COG4913 293 LEAELEELRAELARLEAELERLEARLDALR----EELDELEAQIRgnggdrleQLEREIERLERELEERE--RRRARLEA 366
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1382722093 191 NIDAANAQLRSAEAGLANAQAQ----LEVAEQVQLQIRQQETNVEARQSQVEQARAQLKtAELN 250
Cdd:COG4913 367 LLAALGLPLPASAEEFAALRAEaaalLEALEEELEALEEALAEAEAALRDLRRELRELE-AEIA 429
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
117-295 |
5.59e-05 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 45.14 E-value: 5.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 117 RDATAQRDQAQAQLSLAESQLHQAQAQLALAKVQYPAQRDQAKAQVLRAQAELANARAEYQRQRgVDPRATSKQNIDAAN 196
Cdd:COG4717 91 AELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEER-LEELRELEEELEELE 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 197 AQLRSAEAGLANAQAQLEVAEQVQLQ-----IRQQETNVEARQSQVEQARAQLKTAELNLSYTEVRApFDGYVTKRNVQN 271
Cdd:COG4717 170 AELAELQEELEELLEQLSLATEEELQdlaeeLEELQQRLAELEEELEEAQEELEELEEELEQLENEL-EAAALEERLKEA 248
|
170 180
....*....|....*....|....
gi 1382722093 272 GMLVQAGSALFSIVSPDIWVVANF 295
Cdd:COG4717 249 RLLLLIAAALLALLGLGGSLLSLI 272
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
101-251 |
5.65e-05 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 45.29 E-value: 5.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 101 DNQRVKKGDL---LVVIDPRDATAQR-DQAQAQLSLAESQLHQAQAQLAL--AKVQYPAQRDQAKAQVLRAQAELANARA 174
Cdd:PRK11281 56 AEDKLVQQDLeqtLALLDKIDRQKEEtEQLKQQLAQAPAKLRQAQAELEAlkDDNDEETRETLSTLSLRQLESRLAQTLD 135
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1382722093 175 EYQrqrgvdpraTSKQNIDAANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNL 251
Cdd:PRK11281 136 QLQ---------NAQNDLAEYNSQLVSLQTQPERAQAALYANSQRLQQIRNLLKGGKVGGKALRPSQRVLLQAEQAL 203
|
|
| TolC |
COG1538 |
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; |
125-251 |
6.56e-05 |
|
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441147 [Multi-domain] Cd Length: 367 Bit Score: 44.64 E-value: 6.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 125 QAQAQLSLAESQLHQAQAQLALAKVQYPAQRDQAKAQVLRAQAELANARAEYQrqrgvdpraTSKQNIDAANAQLRSAEA 204
Cdd:COG1538 241 SVGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEVEDALAALR---------AAREQLEALEEALEAAEE 311
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1382722093 205 GLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNL 251
Cdd:COG1538 312 ALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQL 358
|
|
| TolC |
COG1538 |
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; |
102-257 |
1.32e-04 |
|
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441147 [Multi-domain] Cd Length: 367 Bit Score: 43.49 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 102 NQRVKKGDLLVViDPRDATAQRDQAQAQLSLAESQLHQAQAQLAL-----------------AKVQYPAQRD-------- 156
Cdd:COG1538 110 RARYEAGLASRL-DVLQAEAQLAQARAQLAQAEAQLAQARNALALllglpppapldlpdplpPLPPLPPSLPglpseale 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 157 ------QAKAQVLRAQAELANARAE----------YQRQRGVDPRATSKQNI-------------DAANAQLRSAEAGLA 207
Cdd:COG1538 189 rrpdlrAAEAQLEAAEAEIGVARAAflpslslsasYGYSSSDDLFSGGSDTWsvglslslplfdgGRNRARVRAAKAQLE 268
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1382722093 208 NAQAQLEVAE-QVQLQIRQQETNVEARQSQVEQARAQLKTAELNLSYTEVR 257
Cdd:COG1538 269 QAEAQYEQTVlQALQEVEDALAALRAAREQLEALEEALEAAEEALELARAR 319
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
110-247 |
2.03e-04 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 43.79 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 110 LLVVIDPRDATAQRDQAQAQLSLA-ESQLHQAQAQLALAKV--------QYPAQRDQAKAQVLRAQAELANARAEYQRQR 180
Cdd:COG3096 882 QANLLADETLADRLEELREELDAAqEAQAFIQQHGKALAQLeplvavlqSDPEQFEQLQADYLQAKEQQRRLKQQIFALS 961
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1382722093 181 GVDPRATSKQNIDAAnaQLRSAEAGLANA-QAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTA 247
Cdd:COG3096 962 EVVQRRPHFSYEDAV--GLLGENSDLNEKlRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSS 1027
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
118-260 |
2.17e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 43.37 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 118 DATAQRDQAQAQLSLAESQLHQAQAQLALAKVQYPAQRDQAKAQVLRAQAELANARAEYQRQRgvDPRATSKQNIDAANA 197
Cdd:COG4913 342 QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALE--EALAEAEAALRDLRR 419
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1382722093 198 QLRSAEAGLANaqaqlevaeqvqlqIRQQETNVEARqsqVEQARAQLKTAelnLSYTEVRAPF 260
Cdd:COG4913 420 ELRELEAEIAS--------------LERRKSNIPAR---LLALRDALAEA---LGLDEAELPF 462
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
135-251 |
2.18e-04 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 42.79 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 135 SQLHQAQAQLALAKVQYpaqrDQAKAQVLRAQAELANAraeyqrqrgvdpratsKQNIDAANAQLRSAEAGLANAQAQle 214
Cdd:TIGR04320 254 NSLAALQAKLATAQADL----AAAQTALNTAQAALTSA----------------QTAYAAAQAALATAQKELANAQAQ-- 311
|
90 100 110
....*....|....*....|....*....|....*..
gi 1382722093 215 VAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNL 251
Cdd:TIGR04320 312 ALQTAQNNLATAQAALANAEARLAKAKEALANLNADL 348
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
113-248 |
3.38e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 42.98 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 113 VIDPRDATAQRDQAQAQLSlaesQLHQAQAQLALAKvqypAQRDQAkAQVLRAQAELANARAEYQRQRGVDPRA---TSK 189
Cdd:COG4913 217 MLEEPDTFEAADALVEHFD----DLERAHEALEDAR----EQIELL-EPIRELAERYAAARERLAELEYLRAALrlwFAQ 287
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1382722093 190 QNIDAANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQ-----VEQARAQLKTAE 248
Cdd:COG4913 288 RRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGnggdrLEQLEREIERLE 351
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
111-255 |
3.42e-04 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 42.74 E-value: 3.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 111 LVVIDPRDATAQRDQAQAQLSLAESQLHQAQAQLALAKVQypAQRDQAKAQVLRAQAELANARAEYQRQRgvDPRATSKQ 190
Cdd:TIGR02168 304 KQILRERLANLERQLEELEAQLEELESKLDELAEELAELE--EKLEELKEELESLEAELEELEAELEELE--SRLEELEE 379
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1382722093 191 NIDAANAQLRSAEAGLANAQAQLEVAEQV--QLQIRQQETNVEARQSQVEQARAQLKTAELNLSYTE 255
Cdd:TIGR02168 380 QLETLRSKVAQLELQIASLNNEIERLEARleRLEDRRERLQQEIEELLKKLEEAELKELQAELEELE 446
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
117-247 |
4.56e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 42.64 E-value: 4.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 117 RDATAQRDQAQAqlslAESQLHQAQAQLALAKVQY------PAQRDQAKAQVLRAQAELANARAEYQRQRGVDPRATSKQ 190
Cdd:PRK04863 897 EEIREQLDEAEE----AKRFVQQHGNALAQLEPIVsvlqsdPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFS 972
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1382722093 191 NIDAAnaQLRSAEAGLANA-QAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTA 247
Cdd:PRK04863 973 YEDAA--EMLAKNSDLNEKlRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSS 1028
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
117-251 |
4.87e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 42.21 E-value: 4.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 117 RDATAQRDQAQAQLSLAE---SQLHQAQAQLALAKVQ-----YPAQRDQAKAQVLRAQAELANARAEYQ------RQRGV 182
Cdd:COG4913 258 RELAERYAAARERLAELEylrAALRLWFAQRRLELLEaeleeLRAELARLEAELERLEARLDALREELDeleaqiRGNGG 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 183 DPRATSKQNIDAANAQLRSAEAGLANAQAQLEVAE-----------QVQLQIRQQETNVEARQSQVEQARAQLKTAELNL 251
Cdd:COG4913 338 DRLEQLEREIERLERELEERERRRARLEALLAALGlplpasaeefaALRAEAAALLEALEEELEALEEALAEAEAALRDL 417
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
128-250 |
7.37e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 41.68 E-value: 7.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 128 AQLSLAESQLHQAQAQLA-LAKVQypAQRDQAKAQVLRAQAELANARAEYQRQRGVDPRATSKQNIDAANAQLRSAEAGL 206
Cdd:COG4717 71 KELKELEEELKEAEEKEEeYAELQ--EELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERL 148
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1382722093 207 ANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELN 250
Cdd:COG4717 149 EELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEE 192
|
|
| PspA |
COG1842 |
Phage shock protein A [Transcription, Signal transduction mechanisms]; |
118-249 |
8.36e-04 |
|
Phage shock protein A [Transcription, Signal transduction mechanisms];
Pssm-ID: 441447 [Multi-domain] Cd Length: 217 Bit Score: 40.19 E-value: 8.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 118 DATAQRDQAQAQLS--LAESQLHQAQAQLALAKvqypAQRDQAKA---QVLRAQAELANARAEYQRQRGVdpRATSKQNI 192
Cdd:COG1842 48 QVIANQKRLERQLEelEAEAEKWEEKARLALEK----GREDLAREaleRKAELEAQAEALEAQLAQLEEQ--VEKLKEAL 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1382722093 193 DAANAQLRSAEAGLANAQAQLEVAEqVQLQIRQQETNVEARQSQVEQARAQLKTAEL 249
Cdd:COG1842 122 RQLESKLEELKAKKDTLKARAKAAK-AQEKVNEALSGIDSDDATSALERMEEKIEEM 177
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
118-214 |
9.38e-04 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 40.87 E-value: 9.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 118 DATAQRDQAQAQLSLAESQLHQAQAQLALAKVQyPAQrdQAKAQVLRAQAELANARAEYQrqrgvdpratskqnidAANA 197
Cdd:TIGR04320 279 TAQAALTSAQTAYAAAQAALATAQKELANAQAQ-ALQ--TAQNNLATAQAALANAEARLA----------------KAKE 339
|
90
....*....|....*..
gi 1382722093 198 QLRSAEAGLANAQAQLE 214
Cdd:TIGR04320 340 ALANLNADLAKKQAALD 356
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
122-258 |
1.01e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 41.46 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 122 QRDQAQAQLSLAEsQLHQAQAQLALAKvqypaqRDQAKAQVLRAQAELANARAEyqrqrgvdpratskqnIDAANAQLRS 201
Cdd:COG1196 208 QAEKAERYRELKE-ELKELEAELLLLK------LRELEAELEELEAELEELEAE----------------LEELEAELAE 264
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1382722093 202 AEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNLSYTEVRA 258
Cdd:COG1196 265 LEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEL 321
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
114-243 |
1.35e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 41.05 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 114 IDPRDATAQRDQAQAQLSLAE---SQLHQAQAQLALAKVQYPA---QRDQAKAQVLRAQAELANARAEYQR-QRGVDPRA 186
Cdd:COG4913 661 IDVASAEREIAELEAELERLDassDDLAALEEQLEELEAELEEleeELDELKGEIGRLEKELEQAEEELDElQDRLEAAE 740
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1382722093 187 TSKQNIDAANAQLRSAEAGLANAQAQleVAEQVQLQIRQQETNVEARQSQVEQARAQ 243
Cdd:COG4913 741 DLARLELRALLEERFAAALGDAVERE--LRENLEERIDALRARLNRAEEELERAMRA 795
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
146-252 |
1.36e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 40.48 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 146 LAKVQYPAQRDQAKAqvlrAQAELANARAEYQrqrgvdpraTSKQNIDAANAQLRSAEAGLANAQAQLEVAEQVQLQIRQ 225
Cdd:TIGR04320 244 FDKTPIPNPPNSLAA----LQAKLATAQADLA---------AAQTALNTAQAALTSAQTAYAAAQAALATAQKELANAQA 310
|
90 100 110
....*....|....*....|....*....|..
gi 1382722093 226 Q-----ETNVEARQSQVEQARAQLKTAELNLS 252
Cdd:TIGR04320 311 QalqtaQNNLATAQAALANAEARLAKAKEALA 342
|
|
| outer_NodT |
TIGR01845 |
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ... |
121-227 |
1.59e-03 |
|
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]
Pssm-ID: 273830 [Multi-domain] Cd Length: 460 Bit Score: 40.47 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 121 AQRDQAQAQLSLAESQLHQAQ----AQLALAKVQYPAQRDQAKAqvlrAQAELANAR-----AEYQRQRGVDPRAtskqn 191
Cdd:TIGR01845 144 RAVESALAQLEAAEADSQAARltlsASIANAYVQLAALRAQLDV----YHAALASRRktlelTQKRYAAGVAAAS----- 214
|
90 100 110
....*....|....*....|....*....|....*.
gi 1382722093 192 idaanaQLRSAEAGLANAQAQLevaEQVQLQIRQQE 227
Cdd:TIGR01845 215 ------DVRQAEAAVASAEAEL---PSLDVQIAQAR 241
|
|
| PRK09039 |
PRK09039 |
peptidoglycan -binding protein; |
123-257 |
1.62e-03 |
|
peptidoglycan -binding protein;
Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 39.95 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 123 RDQAQAQLSlaeSQLHQAQAQLALAKvqypAQRDQAKAQVLRAQAELANARAEYQRQrgvdpratskQNIDAANAQLRSA 202
Cdd:PRK09039 51 KDSALDRLN---SQIAELADLLSLER----QGNQDLQDSVANLRASLSAAEAERSRL----------QALLAELAGAGAA 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1382722093 203 EAGLANAQAQlEVAEQVQLQIRQQeTNVEARQSQVEQARAQLKTAELNLSYTEVR 257
Cdd:PRK09039 114 AEGRAGELAQ-ELDSEKQVSARAL-AQVELLNQQIAALRRQLAALEAALDASEKR 166
|
|
| OEP |
pfam02321 |
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ... |
139-253 |
1.72e-03 |
|
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.
Pssm-ID: 396757 [Multi-domain] Cd Length: 181 Bit Score: 39.04 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 139 QAQAQLALAKVQYPAQRDQAKAQVLRAQAELANARAEYQrqrgvdpraTSKQNIDAANAQLRSAEAGLANAQAQLEVAEQ 218
Cdd:pfam02321 73 KRRARVKAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLL---------AAKEQLELAEQALELAEEALELAEARYEAGLI 143
|
90 100 110
....*....|....*....|....*....|....*
gi 1382722093 219 VQLQIRQQETNVEARQSQVEQARAQLKTAELNLSY 253
Cdd:pfam02321 144 SLLDVLQAEVELLEARLELLNAEADLELALAQLEQ 178
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
94-251 |
2.00e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 40.43 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 94 VTELRVKDNQRVKKGDLL------VVIDPRDATAQRDQAQAQLSLAESQLHQAQAQLALAKvqypAQRDQAKAQVLRAQA 167
Cdd:TIGR02168 269 LEELRLEVSELEEEIEELqkelyaLANEISRLEQQKQILRERLANLERQLEELEAQLEELE----SKLDELAEELAELEE 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 168 ELANARAEYQRQRgvdpratskQNIDAANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQEtnvEARQSQVEQARAQLKTA 247
Cdd:TIGR02168 345 KLEELKEELESLE---------AELEELEAELEELESRLEELEEQLETLRSKVAQLELQI---ASLNNEIERLEARLERL 412
|
....
gi 1382722093 248 ELNL 251
Cdd:TIGR02168 413 EDRR 416
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
47-248 |
3.15e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 39.75 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 47 LIILGIVVVIMVIGAIIWWFMTRNLETTDDAFIEGDAVTVAPKVA-----GYVTELRVKDNQRVK--KGDLLVVIDPRDA 119
Cdd:COG4717 273 LTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEeeeleELLAALGLPPDLSPEelLELLDRIEELQEL 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 120 TAQRDQAQAQLSLAESQlHQAQAQLALAKVQYPA---QRDQAKAQVLRAQAELANARAEYQRQRGVDPRATSKQNIDAAN 196
Cdd:COG4717 353 LREAEELEEELQLEELE-QEIAALLAEAGVEDEEelrAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELE 431
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1382722093 197 AQLRSAEAGLANAQAQLEVAEQVQLQIRQQ------ETNVEARQSQVEQARAQLKTAE 248
Cdd:COG4717 432 EELEELEEELEELEEELEELREELAELEAEleqleeDGELAELLQELEELKAELRELA 489
|
|
| LpoA |
COG3107 |
Outer membrane lipoprotein LpoA, binds and activates PBP1a [Cell wall/membrane/envelope ... |
99-243 |
3.28e-03 |
|
Outer membrane lipoprotein LpoA, binds and activates PBP1a [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442341 [Multi-domain] Cd Length: 610 Bit Score: 39.56 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 99 VKDNQRVKKGDLLVVIDPRDAT-AQRDQAQ---AQLSLAESQLHQAQAQLALAKVQYPAQRDQAKAQVLRAQAE------ 168
Cdd:COG3107 76 LQEGQLAQARALLAQLPPQQLSpEQQLEYQlllAELALAQGDPEAALALLSQLSLASLSPEQQARYYQLRAQAYeqqgdp 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 169 LANARAEYQRQRGVDPRATSKQNIDAANAQLRSAEAG----LANAQAQLEVAEQVQLQI--RQQETNVEARQSQVEQARA 242
Cdd:COG3107 156 LAAARARIALEPLLTDGQARQENQDQIWQLLSQLPPAqlqsLAINADEPVLQGWLELALiyRQNGGDPDQLQQALNDWQQ 235
|
.
gi 1382722093 243 Q 243
Cdd:COG3107 236 R 236
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
121-257 |
3.79e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 39.65 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 121 AQRDQAQAQLSLAESQLHQAQAQLALAKVQypAQRDQAKAQVLRAQAELANARAEYQRQRgvdpRATSKQNIDAANAQLR 200
Cdd:TIGR02168 789 AQIEQLKEELKALREALDELRAELTLLNEE--AANLRERLESLERRIAATERRLEDLEEQ----IEELSEDIESLAAEIE 862
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1382722093 201 SAEAGLANAQAQLEVA------------------EQVQLQIRQQETNVEARQSQVEQARAQLKTAELNLSYTEVR 257
Cdd:TIGR02168 863 ELEELIEELESELEALlnerasleealallrselEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVR 937
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
117-237 |
5.18e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 39.17 E-value: 5.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 117 RDATAQRDQAQAQLSLAESQLHQAQAQLALAKVQYpaqrdQAKAQVLRA-QAEL----------ANARAEYQRQRGVDPR 185
Cdd:COG3096 994 EQAEEARREAREQLRQAQAQYSQYNQVLASLKSSR-----DAKQQTLQElEQELeelgvqadaeAEERARIRRDELHEEL 1068
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1382722093 186 ATSKQNIDAANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQV 237
Cdd:COG3096 1069 SQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAERDYKQEREQVVQAKAGWCAV 1120
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
121-284 |
5.32e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 38.84 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 121 AQRDQAQAQLSLAESQLHQAQAQ-----LALAKVQYPAQRDQAKAQVLRAQAELANARAEY---QRQRGVDPRATSKQNI 192
Cdd:COG3206 182 EQLPELRKELEEAEAALEEFRQKnglvdLSEEAKLLLQQLSELESQLAEARAELAEAEARLaalRAQLGSGPDALPELLQ 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 193 DAANAQLRSAeagLANAQAQLEvaeqvQLQIRQQETN--VEARQSQVEQARAQLKtAELNLSYTEVRAPFDGYVTKRNVQ 270
Cdd:COG3206 262 SPVIQQLRAQ---LAELEAELA-----ELSARYTPNHpdVIALRAQIAALRAQLQ-QEAQRILASLEAELEALQAREASL 332
|
170
....*....|....
gi 1382722093 271 NGMLVQAGSALFSI 284
Cdd:COG3206 333 QAQLAQLEARLAEL 346
|
|
| type_I_sec_TolC |
TIGR01844 |
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ... |
125-256 |
5.47e-03 |
|
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]
Pssm-ID: 273829 [Multi-domain] Cd Length: 415 Bit Score: 38.51 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 125 QAQAQLSLAESQLHQAQAQLALAKVQY---------------------PAQRDQAKAQVLR--------------AQAEL 169
Cdd:TIGR01844 162 QAEARYASARAQLIQAQNNLDDAKAQLrrlvgqpelaplavpsfpaelPEPLDQLLEIAEAsnplllaaqaavdaARYQV 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 170 ANARAEY---------QRQRGVDPRATSKQNIDAA----------------NAQLRSAEAGLANAQAQLEVAE-QVQLQI 223
Cdd:TIGR01844 242 EQARAGHlptlsltasTGNSDTSSGGSGNSDSDTYsvglnvsiplyqggatSAQVRQAAHQLNQSRSTLESQKrTVRQQV 321
|
170 180 190
....*....|....*....|....*....|...
gi 1382722093 224 RQQETNVEARQSQVEQARAQLKTAELNLSYTEV 256
Cdd:TIGR01844 322 RNAWSNLNAAAASVQAYEQQVASAQKALDAYRQ 354
|
|
| KpsE |
COG3524 |
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; |
113-243 |
5.48e-03 |
|
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442746 [Multi-domain] Cd Length: 370 Bit Score: 38.68 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 113 VIDP-RDATAQRDQAqAQLslaESQLHQAQAQLALAKVQypAQRDQAKAQVLRAQAelanaraeyqrqrgvdpRATSKQn 191
Cdd:COG3524 209 ILDPeATAEALLQLI-ATL---EGQLAELEAELAALRSY--LSPNSPQVRQLRRRI-----------------AALEKQ- 264
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1382722093 192 IDAANAQLRSAEAG--LANAQAQLEVAEqVQLQIRQQetNVEARQSQVEQARAQ 243
Cdd:COG3524 265 IAAERARLTGASGGdsLASLLAEYERLE-LEREFAEK--AYTSALAALEQARIE 315
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
117-302 |
5.69e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 38.34 E-value: 5.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 117 RDATAQRDQAQAQLSLAESQLHQAQAQLALAKvqypAQRDQAKAQVLRAQAELANARAEYQRQRgvDPRATSKQNIDAAN 196
Cdd:COG4372 34 RKALFELDKLQEELEQLREELEQAREELEQLE----EELEQARSELEQLEEELEELNEQLQAAQ--AELAQAQEELESLQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 197 AQLRSAEAGLANAQAQLEV----AEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNLSYTEVRAPFDGYVTKRNVQNG 272
Cdd:COG4372 108 EEAEELQEELEELQKERQDleqqRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDE 187
|
170 180 190
....*....|....*....|....*....|
gi 1382722093 273 MLVQAGSALFSIVSPDIWVVANFKESQLER 302
Cdd:COG4372 188 LLKEANRNAEKEEELAEAEKLIESLPRELA 217
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
114-253 |
6.09e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 38.78 E-value: 6.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 114 IDPRDAtaqRDQAQAQLSLAESQLHQAQaqlalakvQYPAQRDQAKA--QVLRAQAELANARAEYQRQRGVDPratskQN 191
Cdd:PRK04863 489 VSRSEA---WDVARELLRRLREQRHLAE--------QLQQLRMRLSEleQRLRQQQRAERLLAEFCKRLGKNL-----DD 552
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1382722093 192 IDAANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTAELNLSY 253
Cdd:PRK04863 553 EDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAWLAAQDALAR 614
|
|
| PspA_IM30 |
pfam04012 |
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ... |
126-252 |
8.34e-03 |
|
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.
Pssm-ID: 461130 [Multi-domain] Cd Length: 215 Bit Score: 37.35 E-value: 8.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 126 AQAQLSLAESQLHQAQAQLALAKVQYPAQRDQAKAQVLRAQAELANARAEYQRQrGVDPRATSKQNIDAANAQLRSAEAG 205
Cdd:pfam04012 34 MQSELVKARQALAQTIARQKQLERRLEQQTEQAKKLEEKAQAALTKGNEELARE-ALAEKKSLEKQAEALETQLAQQRSA 112
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1382722093 206 LANAQAQLEVAEQVQLQIRQQETNVEARqSQVEQARAQLKTAELNLS 252
Cdd:pfam04012 113 VEQLRKQLAALETKIQQLKAKKNLLKAR-LKAAKAQEAVQTSLGSLS 158
|
|
| PTZ00491 |
PTZ00491 |
major vault protein; Provisional |
121-258 |
8.34e-03 |
|
major vault protein; Provisional
Pssm-ID: 240439 [Multi-domain] Cd Length: 850 Bit Score: 38.46 E-value: 8.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 121 AQRDQAQAQlslAESQLHQAQAQLALAKVQYPAQRDQAKAQVLRAQAELANARAeyqrqrgvdpratSKQNIDAANAQlr 200
Cdd:PTZ00491 663 SQEAAARHQ---AELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAESAAVES-------------SGQSRAEALAE-- 724
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1382722093 201 sAEAGLANAQAQLEVAEqvqlqIRQQETNVEArQSQVEQARAQlktAELNLSYTEVRA 258
Cdd:PTZ00491 725 -AEARLIEAEAEVEQAE-----LRAKALRIEA-EAELEKLRKR---QELELEYEQAQN 772
|
|
| TolC |
COG1538 |
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; |
118-244 |
8.96e-03 |
|
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441147 [Multi-domain] Cd Length: 367 Bit Score: 37.71 E-value: 8.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 118 DATAQRDQAQAQLSLAESQLHQAQAQLALAKVQYPAQRDQ-------------AKAQVLRAQAELANARAEYQRQRGVdp 184
Cdd:COG1538 66 DLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELlelararyeaglaSRLDVLQAEAQLAQARAQLAQAEAQ-- 143
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1382722093 185 RATSKQNIDA-----------ANAQLRSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQL 244
Cdd:COG1538 144 LAQARNALALllglpppapldLPDPLPPLPPLPPSLPGLPSEALERRPDLRAAEAQLEAAEAEIGVARAAF 214
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
144-252 |
9.19e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 37.82 E-value: 9.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 144 LALAKVQYPAQRDQAKAQVLRAQAELANARAEYQRQrgvdpratsKQNIDAANAQLRSAEAGLANAQAQLEVAEQvqlQI 223
Cdd:COG4942 11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAAL---------KKEEKALLKQLAALERRIAALARRIRALEQ---EL 78
|
90 100
....*....|....*....|....*....
gi 1382722093 224 RQQETNVEARQSQVEQARAQLKTAELNLS 252
Cdd:COG4942 79 AALEAELAELEKEIAELRAELEAQKEELA 107
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
117-247 |
9.37e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 38.40 E-value: 9.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382722093 117 RDATAQRDQAQAQLSLAESQLHQAQAQLalakvqypaqrDQAKAQV--LRAQAELANARAEyqrqrgvdprATSKQNIDA 194
Cdd:PRK04863 840 RQLNRRRVELERALADHESQEQQQRSQL-----------EQAKEGLsaLNRLLPRLNLLAD----------ETLADRVEE 898
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1382722093 195 ANAQL---RSAEAGLANAQAQLEVAEQVQLQIRQQETNVEARQSQVEQARAQLKTA 247
Cdd:PRK04863 899 IREQLdeaEEAKRFVQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDA 954
|
|
| |
