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Conserved domains on  [gi|1391517522|gb|PWM92603|]
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MAG: glycosyl transferase [Coprobacter sp.]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 13-411 2.04e-88

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03825:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 364  Bit Score: 272.28  E-value: 2.04e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  13 MVILQINTVCGRGSTGSICVDIASQLEKMGHTCYIAYGQGntdyeksykigsklenylhnigsrllgnqgyytakgtRRL 92
Cdd:cd03825     1 MKVLHINTVDLSGGAARAAYRLHQALLAYGIDSTMLVGRK-------------------------------------KNL 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  93 VKYIEHVKPDIIHLHNLHGNYLNLRIIFNFLSmaGISVVWTLHDCWAFTGKCAHYTsaGCYKWEKQCGHCPQFRSYPSSL 172
Cdd:cd03825    44 ISKPEFIEADIIHLHWIHGGYLSLKALFKLLR--RKPVVWTLHDMWPFTGGCHYPM--ECEGWKTGCGNCPNLNSYPPAK 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 173 FlDRSRRLYTDKKKwFTSIDNMAIVSVSRWLQKEASRSFL-SKYPVSYIYNWVDYKKFFPQP-EDIRKKYQIPEDKFILL 250
Cdd:cd03825   120 K-DLSRQLFRRKRE-ALAKKRLTIVAPSRWLADMVRRSPLlKGLPVVVIPNGIDTEIFAPVDkAKARKRLGIPQDKKVIL 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 251 SVSAGWNKNTSRYKDAMELMKMLP--EDMHLVMVGQCYKDTEIPP-SITHIPYIQGAEELAKVYSAADVYVHLSVEDTFG 327
Cdd:cd03825   198 FGAESVTKPRKGFDELIEALKLLAtkDDLLLVVFGKNDPQIVILPfDIISLGYIDDDEQLVDIYSAADLFVHPSLADNLP 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 328 KVIAEAMACGTPSIVFDSTACPELI--GNNcGYVVRPHNVSDIIAKANIIKKNGKKY--FSTPAINYVKENFDYERNVMQ 403
Cdd:cd03825   278 NTLLEAMACGTPVVAFDTGGSPEIVqhGVT-GYLVPPGDVQALAEAIEWLLANPKEResLGERARALAENHFDQRVQAQR 356


                  ....*...
gi 1391517522 404 IIRLYEKL 411
Cdd:cd03825   357 YLELYKDL 364
 
Name Accession Description Interval E-value
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 13-411 2.04e-88

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 272.28  E-value: 2.04e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  13 MVILQINTVCGRGSTGSICVDIASQLEKMGHTCYIAYGQGntdyeksykigsklenylhnigsrllgnqgyytakgtRRL 92
Cdd:cd03825     1 MKVLHINTVDLSGGAARAAYRLHQALLAYGIDSTMLVGRK-------------------------------------KNL 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  93 VKYIEHVKPDIIHLHNLHGNYLNLRIIFNFLSmaGISVVWTLHDCWAFTGKCAHYTsaGCYKWEKQCGHCPQFRSYPSSL 172
Cdd:cd03825    44 ISKPEFIEADIIHLHWIHGGYLSLKALFKLLR--RKPVVWTLHDMWPFTGGCHYPM--ECEGWKTGCGNCPNLNSYPPAK 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 173 FlDRSRRLYTDKKKwFTSIDNMAIVSVSRWLQKEASRSFL-SKYPVSYIYNWVDYKKFFPQP-EDIRKKYQIPEDKFILL 250
Cdd:cd03825   120 K-DLSRQLFRRKRE-ALAKKRLTIVAPSRWLADMVRRSPLlKGLPVVVIPNGIDTEIFAPVDkAKARKRLGIPQDKKVIL 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 251 SVSAGWNKNTSRYKDAMELMKMLP--EDMHLVMVGQCYKDTEIPP-SITHIPYIQGAEELAKVYSAADVYVHLSVEDTFG 327
Cdd:cd03825   198 FGAESVTKPRKGFDELIEALKLLAtkDDLLLVVFGKNDPQIVILPfDIISLGYIDDDEQLVDIYSAADLFVHPSLADNLP 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 328 KVIAEAMACGTPSIVFDSTACPELI--GNNcGYVVRPHNVSDIIAKANIIKKNGKKY--FSTPAINYVKENFDYERNVMQ 403
Cdd:cd03825   278 NTLLEAMACGTPVVAFDTGGSPEIVqhGVT-GYLVPPGDVQALAEAIEWLLANPKEResLGERARALAENHFDQRVQAQR 356


                  ....*...
gi 1391517522 404 IIRLYEKL 411
Cdd:cd03825   357 YLELYKDL 364
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 302-413 2.30e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 88.89  E-value: 2.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 302 QGAEELAKV-YSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGNN-CGYVVRPHNVSDIIAKANIIKKNG 379
Cdd:COG0438     8 KGLDLLLEAlLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGeTGLLVPPGDPEALAEAILRLLEDP 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1391517522 380 KKY--FSTPAINYVKENFDYERNVMQIIRLYEKLIS 413
Cdd:COG0438    88 ELRrrLGEAARERAEERFSWEAIAERLLALYEELLA 123
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 245-382 3.19e-19

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 83.86  E-value: 3.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 245 DKFILLSVSA-GWNKNTSRYKDAMELMKMLPEDMHLVMVGQ-----CYKD----TEIPPSITHIPYiQGAEELAKVYSAA 314
Cdd:pfam00534   1 KKKIILFVGRlEPEKGLDLLIKAFALLKEKNPNLKLVIAGDgeeekRLKKlaekLGLGDNVIFLGF-VSDEDLPELLKIA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391517522 315 DVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGNN-CGYVVRPHNVSDIIAKANIIKKNGKKY 382
Cdd:pfam00534  80 DVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGeTGFLVKPNNAEALAEAIDKLLEDEELR 148
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 195-372 9.70e-07

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 50.47  E-value: 9.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 195 AIVSVSRWLQKEASRSFLSKYPVsyIYNWVDYKKFFPQPED----IRKKYQIPEDKFILLSVSAGWNKNTSRYKDAMELM 270
Cdd:TIGR04047 141 AVLCVSAAWAAELRAEWGIDATV--VPNGVDAARFSPAADAadaaLRRRLGLRGGPYVLAVGGIEPRKNTIDLLEAFALL 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 271 KMLPEDMHLVMVG---------------QCYKDTEIPPSITHIPYIQGAEELAKVYSAADVYVHLSVEDTFGKVIAEAMA 335
Cdd:TIGR04047 219 RARRPQAQLVIAGgatlfdydayrrefrARAAELGVDPGPVVITGPVPDADLPALYRCADAFAFPSLKEGFGLVVLEALA 298

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1391517522 336 CGTPSIVFDSTACPELIGNNCGYVVRPHNVsDIIAKA 372
Cdd:TIGR04047 299 SGIPVVASDIAPFTEYLGRFDAAWADPSDP-DSIADA 334
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 301-372 1.67e-04

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 43.55  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1391517522 301 IQGaEELAKVYSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELI----GNNCGYVVRPHNVSDIIAKA 372
Cdd:PLN02871  320 LQG-DELSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVAARAGGIPDIIppdqEGKTGFLYTPGDVDDCVEKL 394
 
Name Accession Description Interval E-value
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 13-411 2.04e-88

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 272.28  E-value: 2.04e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  13 MVILQINTVCGRGSTGSICVDIASQLEKMGHTCYIAYGQGntdyeksykigsklenylhnigsrllgnqgyytakgtRRL 92
Cdd:cd03825     1 MKVLHINTVDLSGGAARAAYRLHQALLAYGIDSTMLVGRK-------------------------------------KNL 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  93 VKYIEHVKPDIIHLHNLHGNYLNLRIIFNFLSmaGISVVWTLHDCWAFTGKCAHYTsaGCYKWEKQCGHCPQFRSYPSSL 172
Cdd:cd03825    44 ISKPEFIEADIIHLHWIHGGYLSLKALFKLLR--RKPVVWTLHDMWPFTGGCHYPM--ECEGWKTGCGNCPNLNSYPPAK 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 173 FlDRSRRLYTDKKKwFTSIDNMAIVSVSRWLQKEASRSFL-SKYPVSYIYNWVDYKKFFPQP-EDIRKKYQIPEDKFILL 250
Cdd:cd03825   120 K-DLSRQLFRRKRE-ALAKKRLTIVAPSRWLADMVRRSPLlKGLPVVVIPNGIDTEIFAPVDkAKARKRLGIPQDKKVIL 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 251 SVSAGWNKNTSRYKDAMELMKMLP--EDMHLVMVGQCYKDTEIPP-SITHIPYIQGAEELAKVYSAADVYVHLSVEDTFG 327
Cdd:cd03825   198 FGAESVTKPRKGFDELIEALKLLAtkDDLLLVVFGKNDPQIVILPfDIISLGYIDDDEQLVDIYSAADLFVHPSLADNLP 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 328 KVIAEAMACGTPSIVFDSTACPELI--GNNcGYVVRPHNVSDIIAKANIIKKNGKKY--FSTPAINYVKENFDYERNVMQ 403
Cdd:cd03825   278 NTLLEAMACGTPVVAFDTGGSPEIVqhGVT-GYLVPPGDVQALAEAIEWLLANPKEResLGERARALAENHFDQRVQAQR 356


                  ....*...
gi 1391517522 404 IIRLYEKL 411
Cdd:cd03825   357 YLELYKDL 364
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 23-409 1.83e-37

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 139.60  E-value: 1.83e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  23 GRGSTGSICVDIASQLEKMGHTCY-IAYGQGNTDYEKSYKIGSKLENYLHNIGSRLlgnqgyytAKGTRRLVKYIEHVKP 101
Cdd:cd03801    12 PVGGAERHVRELARALAARGHDVTvLTPADPGEPPEELEDGVIVPLLPSLAALLRA--------RRLLRELRPLLRLRKF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 102 DIIHLHNLHGNYLnlriIFNFLSMAGISVVWTLHDcwaftgkcahytsagcykwekqcghcpqFRSYPSSLFLDRSRRLY 181
Cdd:cd03801    84 DVVHAHGLLAALL----AALLALLLGAPLVVTLHG----------------------------AEPGRLLLLLAAERRLL 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 182 TDKKKWFTSIDnmAIVSVSRWLQKEASRSF-LSKYPVSYIYNWVDYKKFFPqpeDIRKKYQIPEDKFILLSVSAGWN-KN 259
Cdd:cd03801   132 ARAEALLRRAD--AVIAVSEALRDELRALGgIPPEKIVVIPNGVDLERFSP---PLRRKLGIPPDRPVLLFVGRLSPrKG 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 260 TSRYKDAMELMKMLPEDMHLVMVGQ--------CYKDTEIPPSITHIPYIqGAEELAKVYSAADVYVHLSVEDTFGKVIA 331
Cdd:cd03801   207 VDLLLEALAKLLRRGPDVRLVIVGGdgplraelEELELGLGDRVRFLGFV-PDEELPALYAAADVFVLPSRYEGFGLVVL 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 332 EAMACGTPSIVFDSTACPELIGNN-CGYVVRPHNVSDIIAKANIIKKNGKKY--FSTPAINYVKENFDYERNVMQIIRLY 408
Cdd:cd03801   286 EAMAAGLPVVATDVGGLPEVVEDGeGGLVVPPDDVEALADALLRLLADPELRarLGRAARERVAERFSWERVAERLLDLY 365


                  .
gi 1391517522 409 E 409
Cdd:cd03801   366 R 366
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 37-411 4.39e-22

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 96.96  E-value: 4.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  37 QLEKMGHTCYIAYG--QGNTDYEKSYKIGSklenylhnIGSRLLGNQGYYTAKGTRRLV-KYIEHVKPDIIHLHN--LHG 111
Cdd:cd03817    26 ALEKRGHEVYVITPsdPGAEDEEEVVRYRS--------FSIPIRKYHRQHIPFPFKKAViDRIKELGPDIIHTHTpfSLG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 112 nYLNLRIIFNFlsmaGISVVWTLHDCWAftgkcaHYTsagcykwekqcgHcpqfrsYPSSLFLDRSRRLYTDKKKWFTSI 191
Cdd:cd03817    98 -KLGLRIARKL----KIPIVHTYHTMYE------DYL------------H------YIPKGKLLVKAVVRKLVRRFYNHT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 192 DnmAIVSVSRwLQKEASRSFLSKYPVSYIYNWVDYKKF-FPQPEDIRKKYQIPEDKFILLSVSA-GWNKNTSRYKDAMEL 269
Cdd:cd03817   149 D--AVIAPSE-KIKDTLREYGVKGPIEVIPNGIDLDKFeKPLNTEERRKLGLPPDEPILLYVGRlAKEKNIDFLLRAFAE 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 270 MKMLPeDMHLVMVGQCY---------KDTEIPPSIT---HIPYiqgaEELAKVYSAADVYVHLSVEDTFGKVIAEAMACG 337
Cdd:cd03817   226 LKKEP-NIKLVIVGDGPereelkelaRELGLADKVIftgFVPR----EELPEYYKAADLFVFASTTETQGLVYLEAMAAG 300

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391517522 338 TPSIVFDSTACPELIGN--NcGYVVRPHNVSDIIAKANIIK-KNGKKYFSTPAINYVkENFDYERnvmQIIRLYEKL 411
Cdd:cd03817   301 LPVVAAKDPAASELVEDgeN-GFLFEPNDETLAEKLLHLREnLELLRKLSKNAEISA-REFAFAK---SVEKLYEEV 372
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 224-370 5.40e-22

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 96.59  E-value: 5.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 224 VDYKKFFPQP--EDIRKKYQiPEDKFILLSVS-AGWNKNTSRYKDAMELMKMLPeDMHLVMVG---QCYKDTEIPPSITH 297
Cdd:cd03814   175 VDTELFHPSRrdAALRRRLG-PPGRPLLLYVGrLAPEKNLEALLDADLPLAASP-PVRLVVVGdgpARAELEARGPDVIF 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391517522 298 IPYIQGaEELAKVYSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGN-NCGYVVRPHNVSDIIA 370
Cdd:cd03814   253 TGFLTG-EELARAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRPgGTGALVEPGDAAAFAA 325
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 302-413 2.30e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 88.89  E-value: 2.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 302 QGAEELAKV-YSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGNN-CGYVVRPHNVSDIIAKANIIKKNG 379
Cdd:COG0438     8 KGLDLLLEAlLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGeTGLLVPPGDPEALAEAILRLLEDP 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1391517522 380 KKY--FSTPAINYVKENFDYERNVMQIIRLYEKLIS 413
Cdd:COG0438    88 ELRrrLGEAARERAEERFSWEAIAERLLALYEELLA 123
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 96-371 4.07e-21

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 93.97  E-value: 4.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  96 IEHVKPDIIHLHNlhgnylnlriIFNFLSMAGISVVWTLHDCWAFTgkcahytsagcykwekqcghCPQFrsYPSSLFLD 175
Cdd:cd03809    80 PKKDKPDLLHSPH----------NTAPLLLKGCPQVVTIHDLIPLR--------------------YPEF--FPKRFRLY 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 176 RSRRLYTDKKKwftsidNMAIVSVSRWLQKEASRsFLSKYP--VSYIYNWVDYKKFFPQPEDIRKKYQIPEDKFILLSVS 253
Cdd:cd03809   128 YRLLLPISLRR------ADAIITVSEATRDDIIK-FYGVPPekIVVIPLGVDPSFFPPESAAVLIAKYLLPEPYFLYVGT 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 254 AGWNKNTSRYKDAMELMKMLPEDMHLVMVGQC----------YKDTEIPPSITHIPYIqGAEELAKVYSAADVYVHLSVE 323
Cdd:cd03809   201 LEPRKNHERLLKAFALLKKQGGDLKLVIVGGKgwedeelldlVKKLGLGGRVRFLGYV-SDEDLPALYRGARAFVFPSLY 279

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1391517522 324 DTFGKVIAEAMACGTPSIVFDSTACPElIGNNCGYVVRPHNVSDIIAK 371
Cdd:cd03809   280 EGFGLPVLEAMACGTPVIASNISVLPE-VAGDAALYFDPLDPESIADA 326
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 90-372 7.83e-21

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 93.21  E-value: 7.83e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  90 RRLVKYIEHVKPDIIHLHNLHGN-YLNLRIIFnflsMAGISVVWTLHdcwaftgkcahytSAGCYKWEKQCGHCPQFRSy 168
Cdd:cd03798    85 AKLLKRRRRGPPDLIHAHFAYPAgFAAALLAR----LYGVPYVVTEH-------------GSDINVFPPRSLLRKLLRW- 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 169 psslFLDRSRRlytdkkkwftsidnmaIVSVSRWLQKEASRSFLSKYPVSYIYNWVDYKKFFPQPEDIRKkyqiPEDKFI 248
Cdd:cd03798   147 ----ALRRAAR----------------VIAVSKALAEELVALGVPRDRVDVIPNGVDPARFQPEDRGLGL----PLDAFV 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 249 LLSVsagwnKNTSRYK------DAMELMKMLPEDMHLVMVG------QCYKDTE---IPPSIT---HIPYiqgaEELAKV 310
Cdd:cd03798   203 ILFV-----GRLIPRKgidlllEAFARLAKARPDVVLLIVGdgplreALRALAEdlgLGDRVTftgRLPH----EQVPAY 273

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1391517522 311 YSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGN-NCGYVVRPHNvSDIIAKA 372
Cdd:cd03798   274 YRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDpETGLLVPPGD-ADALAAA 335
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 91-411 6.43e-20

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 90.45  E-value: 6.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  91 RLVKYIEHVKPDIIHLHNLHGNYLNLriifnfLSM---AGISVVWTLHDCWAFtgkcahytsagcykwekqcghcpqfrs 167
Cdd:cd03807    70 RLAKLIRKRNPDVVHTWMYHADLIGG------LAAklaGGVKVIWSVRSSNIP--------------------------- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 168 YPSSLFLdrsRRLYTDKKKWFtsidnMAIVSVSRWLQKEASRSFLSKYPVSYIYNWVDYKKF---FPQPEDIRKKYQIPE 244
Cdd:cd03807   117 QRLTRLV---RKLCLLLSKFS-----PATVANSSAVAEFHQEQGYAKNKIVVIYNGIDLFKLspdDASRARARRRLGLAE 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 245 DKFILLSVSAGW-NKNTSRYKDAMELMKMLPEDMHLVMVGQCykdteiPPSITHIPYIQ--GAEE----------LAKVY 311
Cdd:cd03807   189 DRRVIGIVGRLHpVKDHSDLLRAAALLVETHPDLRLLLVGRG------PERPNLERLLLelGLEDrvhllgersdVPALL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 312 SAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGNNCGYVVRPHNVSDiIAKAnIIK----KNGKKYFSTPA 387
Cdd:cd03807   263 PAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVDDGTGFLVPAGDPQA-LADA-IRAlledPEKRARLGRAA 340

                         330       340
                  ....*....|....*....|....
gi 1391517522 388 INYVKENFDYERnvmqIIRLYEKL 411
Cdd:cd03807   341 RERIANEFSIDA----MVRRYETL 360
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 25-370 1.20e-19

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 89.70  E-value: 1.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  25 GSTGSICVDIASQLEKMGHTcYIAYGQGNTDYEKSYKIGSKLENYLHNIGSRLLGNQG-------YYTAKGTRRLVKYIE 97
Cdd:cd03823    15 GGAEISVHDLAEALVAEGHE-VAVLTAGVGPPGQATVARSVVRYRRAPDETLPLALKRrgyelfeTYNPGLRRLLARLLE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  98 HVKPDIIHLHNLHGnyLNLRIIFNFLSMaGISVVWTLHDCWAFtgkcahytsagcykwekqCGHCpqfrsypsSLFLDRS 177
Cdd:cd03823    94 DFRPDVVHTHNLSG--LGASLLDAARDL-GIPVVHTLHDYWLL------------------CPRQ--------FLFKKGG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 178 RrlytdkkkwftsidnmAIVSVSRWLQKEASRSFLSKYPVSYIYNWVDY-----KKFFPQPEDIRKKY--QIPEDKFILL 250
Cdd:cd03823   145 D----------------AVLAPSRFTANLHEANGLFSARISVIPNAVEPdlappPRRRPGTERLRFGYigRLTEEKGIDL 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 251 SVSAgwnkntsrykdameLMKMLPEDMHLVMVGQC----YKDTEIPPSITHIPYIQGaEELAKVYSAADVYVHLSV-EDT 325
Cdd:cd03823   209 LVEA--------------FKRLPREDIELVIAGHGplsdERQIEGGRRIAFLGRVPT-DDIKDFYEKIDVLVVPSIwPEP 273

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1391517522 326 FGKVIAEAMACGTPSIVFDSTACPELI--GNNcGYVVRPHNVSDIIA 370
Cdd:cd03823   274 FGLVVREAIAAGLPVIASDLGGIAELIqpGVN-GLLFAPGDAEDLAA 319
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 245-382 3.19e-19

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 83.86  E-value: 3.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 245 DKFILLSVSA-GWNKNTSRYKDAMELMKMLPEDMHLVMVGQ-----CYKD----TEIPPSITHIPYiQGAEELAKVYSAA 314
Cdd:pfam00534   1 KKKIILFVGRlEPEKGLDLLIKAFALLKEKNPNLKLVIAGDgeeekRLKKlaekLGLGDNVIFLGF-VSDEDLPELLKIA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391517522 315 DVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGNN-CGYVVRPHNVSDIIAKANIIKKNGKKY 382
Cdd:pfam00534  80 DVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGeTGFLVKPNNAEALAEAIDKLLEDEELR 148
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 195-399 9.92e-19

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 87.40  E-value: 9.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 195 AIVSVSRWLQKEASRSFLSKYPVSYIYNWVDYKKFFPQPEDIRKKYQIPEDKFILL-SVSAGWNKNTSRYKDAMELMKML 273
Cdd:cd03794   166 AIIVLSPGLKEYLLRKGVPKEKIIVIPNWADLEEFKPPPKDELRKKLGLDDKFVVVyAGNIGKAQGLETLLEAAERLKRR 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 274 PeDMHLVMVGQC--------YKDTEIPPSITHIPYiQGAEELAKVYSAADV-YVHLSVEDTFGKVIA----EAMACGTPS 340
Cdd:cd03794   246 P-DIRFLFVGDGdekerlkeLAKARGLDNVTFLGR-VPKEEVPELLSAADVgLVPLKDNPANRGSSPsklfEYMAAGKPI 323

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1391517522 341 IVFDSTACPELIG-NNCGYVVRPHNVSDIIAKANIIKKNgKKYFSTPAIN---YVKENFDYER 399
Cdd:cd03794   324 LASDDGGSDLAVEiNGCGLVVEPGDPEALADAILELLDD-PELRRAMGENgreLAEEKFSREK 385
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
265-371 8.68e-18

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 79.48  E-value: 8.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 265 DAMELMKMLPEDMHLVMVGQCYKDT------EIPPSITHIPYIqgaEELAKVYSAADVYVHLSVEDTFGKVIAEAMACGT 338
Cdd:pfam13692  22 EAVPLLRKRDNDVRLVIVGDGPEEEleelaaGLEDRVIFTGFV---EDLAELLAAADVFVLPSLYEGFGLKLLEAMAAGL 98

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1391517522 339 PSIVFDSTACPELIGNNCGYVVRPHNVSDIIAK 371
Cdd:pfam13692  99 PVVATDVGGIPELVDGENGLLVPPGDPEALAEA 131
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 177-405 1.37e-17

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 83.57  E-value: 1.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 177 SRRLYTDKKKWFTSI------DNMAIVSVSRWLQKEASRSFLSKYPVSYIYNWVDYKKFFPQPEDIRKKYqIPEDKFILL 250
Cdd:cd03821   130 ALQQKHWKKRIALHLierrnlNNAALVHFTSEQEADELRRFGLEPPIAVIPNGVDIPEFDPGLRDRRKHN-GLEDRRIIL 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 251 SVSAGWNKntsryKDAMELMKMLPE------DMHLVMVG----------QCYKDTEIPPSITHIPYIQGaEELAKVYSAA 314
Cdd:cd03821   209 FLGRIHPK-----KGLDLLIRAARKlaeqgrDWHLVIAGpddgaypaflQLQSSLGLGDRVTFTGPLYG-EAKWALYASA 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 315 DVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGNNCGYVVRPhNVSDI----------IAKANIIKKNGKKYFS 384
Cdd:cd03821   283 DLFVLPSYSENFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDP-NVSSLaealaealrdPADRKRLGEMARRARQ 361

                         250       260
                  ....*....|....*....|.
gi 1391517522 385 tpainyVKENFDYERNVMQII 405
Cdd:cd03821   362 ------VEENFSWEAVAGQLG 376
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 16-411 3.42e-17

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 82.40  E-value: 3.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  16 LQINTVC--GRGSTGSICVDIASQLEKMGHTC-YIAYGQgntdyekSYKIGSKLEN-YLHNIG--SRLLGNQGYYTAKGT 89
Cdd:cd04962     1 MKIGIVCypSYGGSGVVATELGLELAERGHEVhFISSAI-------PFRLNLYSGNiFFHEVEvpNYPLFEYPPYTLALA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  90 RRLVKYIEHVKPDIIHLH----NLHGNYLNLRIIfnflsMAGISVVWTLHDcwaftgkcAHYTSAGcykwekqcghcpqf 165
Cdd:cd04962    74 SKIVEVAKEHKLDVLHAHyaipHASCAYLAREIL-----GEKIPIVTTLHG--------TDITLVG-------------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 166 rsypsslfLDRSrrlYTDKKKWftSIDNMAIV-SVSRWLQKEASRSFLSKYPVSYIYNWVDYKKFFPQPED-IRKKYQIP 243
Cdd:cd04962   127 --------YDPS---LQPAVRF--SINKSDRVtAVSSSLRQETYELFDVDKDIEVIHNFIDEDVFKRKPAGaLKRRLLAP 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 244 EDKFILLSVSagwN-KNTSRYKDAMELMKMLPEDM--HLVMVGQcykDTEIPPS---------ITHIPYIQGAEELAKVY 311
Cdd:cd04962   194 PDEKVVIHVS---NfRPVKRIDDVVRVFARVRRKIpaKLLLVGD---GPERVPAeelarelgvEDRVLFLGKQDDVEELL 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 312 SAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGNN-CGYVVRPHNVSDIIAKANIIKKNGKKY--FSTPAI 388
Cdd:cd04962   268 SIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKHGeTGFLSDVGDVDAMAKSALSILEDDELYnrMGRAAR 347

                         410       420
                  ....*....|....*....|...
gi 1391517522 389 NYVKENFDYERNVMQIIRLYEKL 411
Cdd:cd04962   348 KRAAERFDPERIVPQYEAYYRRL 370
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 32-372 5.91e-17

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 81.63  E-value: 5.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  32 VDIASQLEKMGHTCYIAyGQGNTDYEKSYKIGSKLENYLHNIGSRLLGNqgyytakgtRRLVKYIEHVKPDIIHLHNLHG 111
Cdd:cd03819    18 LDLARALAERGHRVLVV-TAGGPLLPRLRQIGIGLPGLKVPLLRALLGN---------VRLARLIRRERIDLIHAHSRAP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 112 NYLNLRIifnfLSMAGISVVWTLHDCwaftgkcahytsagcykwekqcghcpQFRSYPSSLFLDRSRrlytdkkkwfTSI 191
Cdd:cd03819    88 AWLGWLA----SRLTGVPLVTTVHGS--------------------------YLATYHPKDFALAVR----------ARG 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 192 DNMAIVSVS-RWLQKEASRsfLSKYPVSYIYNWVDYKKFFPQPEDI-RKKYQIPEDKFILLSVS--AGWnKNTSRYKDAM 267
Cdd:cd03819   128 DRVIAVSELvRDHLIEALG--VDPERIRVIPNGVDTDRFPPEAEAEeRAQLGLPEGKPVVGYVGrlSPE-KGWLLLVDAA 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 268 ELMKMLPeDMHLVMVGqcykDTEIPPSITH----------IPYIQGAEELAKVYSAADVYVHLSVEDTFGKVIAEAMACG 337
Cdd:cd03819   205 AELKDEP-DFRLLVAG----DGPERDEIRRlverlglrdrVTFTGFREDVPAALAASDVVVLPSLHEEFGRVALEAMACG 279

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1391517522 338 TPSIVFDSTACPELIGNNC-GYVVRPHNVSDIIAKA 372
Cdd:cd03819   280 TPVVATDVGGAREIVVHGRtGLLVPPGDAEALADAI 315
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 32-375 8.02e-17

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 81.25  E-value: 8.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  32 VDIASQLEKMGHTCYIAYGQGNTDYEKSYKIGSKLENYLHNIGSRLLGNQGyytaKGTRRLVKYIEHVKPDIIHLHNLHG 111
Cdd:cd03811    19 LNLANALDKRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGLL----KAILKLKRILKRAKPDVVISFLGFA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 112 NYlnlriIFNFLSMAGISVVWTLHdcwaftgkcahytsagcykwekqcghcpqfrSYPSSLFLDRSRRLYTDKKKWFTSi 191
Cdd:cd03811    95 TY-----IVAKLAAARSKVIAWIH-------------------------------SSLSKLYYLKKKLLLKLKLYKKAD- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 192 dnmAIVSVSRWLQKEASRSF-LSKYPVSYIYNWVDYKKFFPQPEDirKKYQIPEDKFILLSVSAGwnkntSRYKD---AM 267
Cdd:cd03811   138 ---KIVCVSKGIKEDLIRLGpSPPEKIEVIYNPIDIDRIRALAKE--PILNEPEDGPVILAVGRL-----DPQKGhdlLI 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 268 ELMKMLPEDM---HLVMVGQCYKDTEIppsithipyIQGAEEL---------------AKVYSAADVYVHLSVEDTFGKV 329
Cdd:cd03811   208 EAFAKLRKKYpdvKLVILGDGPLREEL---------EKLAKELglaerviflgfqsnpYPYLKKADLFVLSSRYEGFPNV 278

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1391517522 330 IAEAMACGTPSIVFDSTACPELIGNN-CGYVVRPHNVSDIIAKANII 375
Cdd:cd03811   279 LLEAMALGTPVVSTDCPGPREILDDGeNGLLVPDGDAAALAGILAAL 325
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 33-368 4.03e-16

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 79.18  E-value: 4.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  33 DIASQLEKMGHTCYIAYGQGNTDYEKSYKIGSKLenylHNIGSRLLGNQGYYTAKGTRRLVKYIEHVKPDIIHLH----N 108
Cdd:cd03808    18 PLIKALVKKGYEVHVIAPDGDKLSDELKELGVKV----IDIPILRRGINPLKDLKALFKLYKLLKKEKPDIVHCHtpkpG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 109 LHGnylnlRIIFNFLSmaGISVVWTLHDcWAFTgKCAHYTSAGCYKWekqcghcpqfrsypsslfLDRSRRLYTDKkkwf 188
Cdd:cd03808    94 ILG-----RLAARLAG--VPKVIYTVHG-LGFV-FTEGKLLRLLYLL------------------LEKLALLFTDK---- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 189 tsidnmaIVSVSRWLQKEASRSFLSKYPVSYIY--NWVDYKKFFPQPEdirkkyQIPEDKFILLSVS-AGWNKNTSRYKD 265
Cdd:cd03808   143 -------VIFVNEDDRDLAIKKGIIKKKKTVLIpgSGVDLDRFQYSPE------SLPSEKVVFLFVArLLKDKGIDELIE 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 266 AMELMKMLPEDMHLVMVGQCykDTEIPPSIT--------HIPYIQGAEELAKVYSAADVYVHLSVEDTFGKVIAEAMACG 337
Cdd:cd03808   210 AAKILKKKGPNVRFLLVGDG--ELENPSEILieklglegRIEFLGFRSDVPELLAESDVFVLPSYREGLPRSLLEAMAAG 287

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1391517522 338 TPSIVFDSTACPELI--GNNcGYVVRPHNVSDI 368
Cdd:cd03808   288 RPVITTDVPGCRELVidGVN-GFLVPPGDVEAL 319
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 15-373 3.32e-12

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 67.47  E-value: 3.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  15 ILQINTVCGRGSTGSICVDIASQLEKMGHTCYIAYGQGNTDYEKSYKIgskleNYLHNIGsrlLGNQGYYTAKGTRRLVK 94
Cdd:cd04951     2 ILYVITGLGLGGAEKQTVLLADQMFIRGHDVNIVYLTGEVEVKPLNNN-----IIIYNLG---MDKNPRSLLKALLKLKK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  95 YIEHVKPDIIHLHNLHGNylnlriIFNFLSmagisvvwtlhdcwaftgkCAHYTSAG--CYKWEKQCGHCPQFRSYPSSL 172
Cdd:cd04951    74 IISAFKPDVVHSHMFHAN------IFARFL-------------------RMLYPIPLliCTAHNKNEGGRIRMFIYRLTD 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 173 FLdrsrrlyTDKKkwfTSIDNMAivsVSRWLQKEAsrsfLSKYPVSYIYNWVDYKKFFPQPED---IRKKYQIPEDKFIL 249
Cdd:cd04951   129 FL-------CDIT---TNVSREA---LDEFIAKKA----FSKNKSVPVYNGIDLNKFKKDINVrlkIRNKLNLKNDEFVI 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 250 LSVSagwnkNTSRYKDAMELMKMLPE------DMHLVMVGQCYKDTEIPPSITH------IPYIQGAEELAKVYSAADVY 317
Cdd:cd04951   192 LNVG-----RLTEAKDYPNLLLAISElilsknDFKLLIAGDGPLRNELERLICNlnlvdrVILLGQISNISEYYNAADLF 266

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1391517522 318 VHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIGNNcGYVVRPHNVSDIIAKAN 373
Cdd:cd04951   267 VLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDH-NYVVPVSDPQLLAEKIK 321
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 90-359 3.82e-11

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 62.81  E-value: 3.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  90 RRLVKYIEHVKPDIIHLHNLHGNYLNLRIIfnfLSMAGISVVWTLHDCWAFTGKcahytsagcykwekqcghcpqfRSYP 169
Cdd:cd01635    44 RRILKKLLELKPDVVHAHSPHAAALAALLA---ARLLGIPIVVTVHGPDSLEST----------------------RSEL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 170 SSLFLDRSRRLYTDKkkwftsidnmaiVSVSRWLQKEASRSFLskypvsyiynwvdykkffpqpEDIRKKYQIPEDKFIL 249
Cdd:cd01635    99 LALARLLVSLPLADK------------VSVGRLVPEKGIDLLL---------------------EALALLKARLPDLVLV 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 250 LSVSAGWNKntsrYKDAMELMKMLPEDmhlvmvgqcykdteippsITHIPYIQGAEELAKVYSAADVYVHLSVEDTFGKV 329
Cdd:cd01635   146 LVGGGGERE----EEEALAAALGLLER------------------VVIIGGLVDDEVLELLLAAADVFVLPSRSEGFGLV 203

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1391517522 330 IAEAMACGTPSIVFDSTACPELI--GNNCGYV 359
Cdd:cd01635   204 LLEAMAAGKPVIATDVGGIPEFVvdGENGLLV 235
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 224-368 2.76e-10

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 61.49  E-value: 2.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 224 VDYKKFFPQP--EDIRKKYQIPEDKFILLSVS-AGWNKNTSRYKDAMELMKMLPEDMHLVMVG-----QCYKDTEIPPSI 295
Cdd:cd03800   196 VDLERFFPVDraEARRARLLLPPDKPVVLALGrLDPRKGIDTLVRAFAQLPELRELANLVLVGgpsddPLSMDREELAEL 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 296 THIPYI---------QGAEELAKVYSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELI--GNNcGYVVRPHN 364
Cdd:cd03800   276 AEELGLidrvrfpgrVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVrdGRT-GLLVDPHD 354


                  ....
gi 1391517522 365 VSDI 368
Cdd:cd03800   355 PEAL 358
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 15-398 2.22e-09

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 58.45  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  15 ILQINTVCGRGSTGSICVDIASQLEKMG-HTCYIAYGQGNTDYEKSYK-IGSKLeNYLHNIGSRLLGnqgYYtakgtRRL 92
Cdd:cd03812     2 ILHIVGGMNVGGIETFLMNLYRKLDKSKiEFDFLATSDDKGEYDEELEeLGGKI-FYIPPKKKNIIK---YF-----IKL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  93 VKYIEHVKPDIIHLHNLHGNYLNLRIIFNFlsmaGISVVwTLHdcwaftgkcAHYTsagcyKWEKQcghcpQFRSYPSSL 172
Cdd:cd03812    73 LKLIKKEKYDIVHVHGSSSNGIILLLAAKA----GVPVR-IAH---------SHNT-----KDSSI-----KLRKIRKNV 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 173 FLDRSRRLYTdkKKWFTSIDnmaivsVSRWLQKEASRSflskyPVSYIYNWVDYKKF-FPQP-EDIRKKYQIPEDKFILL 250
Cdd:cd03812   129 LKKLIERLST--KYLACSED------AGEWLFGEVENG-----KFKVIPNGIDIEKYkFNKEkRRKRRKLLILEDKLVLG 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 251 SVsAGWN--KNTSRYKDAMELMKMLPEDMHLVMVGQCYKDTEIPPSITH------IPYIQGAEELAKVYSAADVYVHLSV 322
Cdd:cd03812   196 HV-GRFNeqKNHSFLIDIFEELKKKNPNVKLVLVGEGELKEKIKEKVKElgledkVIFLGFRNDVSEILSAMDVFLFPSL 274

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1391517522 323 EDTFGKVIAEAMACGTPSIVFDSTACPELIGNNCGYVvrPHNVSDIIAKANIIKKNGKKYFSTPAINYVKENFDYE 398
Cdd:cd03812   275 YEGLPLVAVEAQASGLPCLLSDTITKECDITNNVEFL--PLNETPSTWAEKILKLIKRKRRINKEINKEKKELGYD 348
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 303-409 6.23e-08

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 54.65  E-value: 6.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 303 GAEELAKVYSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELIG------NNCGYVVRPHNVSDiIAKAnIIK 376
Cdd:cd03813   360 GFQNIKEYYPKLGLLVLTSISEGQPLVILEAMASGVPVVATDVGSCRELIYgaddalGQAGLVVPPADPEA-LAEA-LIK 437

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1391517522 377 --KNGKKY--FSTPAINYVKENFDYERNVMQIIRLYE 409
Cdd:cd03813   438 llRDPELRqaFGEAGRKRVEKYYTLEGMIDSYRKLYL 474
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
32-225 6.86e-08

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 51.76  E-value: 6.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522  32 VDIASQLEKMGHTCYIAYGQGNTDYEKSYKIGSKLENYLHNIGSRLlgnqgYYTAKGTRRLVKYIEHVKPDIIHLHNLHG 111
Cdd:pfam13439   8 LELARALARRGHEVTVVTPGGPGPLAEEVVRVVRVPRVPLPLPPRL-----LRSLAFLRRLRRLLRRERPDVVHAHSPFP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 112 NYLNLRIifnFLSMAGISVVWTLHDCWAFTGkcahytsagcykwekqcghcpqFRSYPSSLFLDRSRRLYtdkKKWFTSI 191
Cdd:pfam13439  83 LGLAALA---ARLRLGIPLVVTYHGLFPDYK----------------------RLGARLSPLRRLLRRLE---RRLLRRA 134

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1391517522 192 DnmAIVSVSRWLQKEASRSF-LSKYPVSYIYNWVD 225
Cdd:pfam13439 135 D--RVIAVSEAVADELRRLYgVPPEKIRVIPNGVD 167
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 193-411 7.09e-08

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 53.83  E-value: 7.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 193 NMAIVSVSRwlqKEASRSFLSKYPvSYIYNWVDYKKFFPQPEdirkkyqiPEDKFILLS-VSAgwNKNtsrYKDAMELMK 271
Cdd:cd03802   130 PVNYVSISD---AQRAATPPIDYL-TVVHNGLDPADYRFQPD--------PEDYLAFLGrIAP--EKG---LEDAIRVAR 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 272 MLpeDMHLVMVGQC------YKDTEIPPSiTHIPYIQ--GAEELAKVYSAADVYVHLSV-EDTFGKVIAEAMACGTPSIV 342
Cdd:cd03802   193 RA--GLPLKIAGKVrdedyfYYLQEPLPG-PRIEFIGevGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIA 269

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1391517522 343 FDSTACPELIGNN-CGYVVRPhnVSDIIAKANIIKKngkkyFSTPAIN-YVKENFDYERNVMQIIRLYEKL 411
Cdd:cd03802   270 YRRGGLPEVIQHGeTGFLVDS--VEEMAEAIANIDR-----IDRAACRrYAEDRFSAARMADRYEALYRKV 333
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 195-372 9.70e-07

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 50.47  E-value: 9.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 195 AIVSVSRWLQKEASRSFLSKYPVsyIYNWVDYKKFFPQPED----IRKKYQIPEDKFILLSVSAGWNKNTSRYKDAMELM 270
Cdd:TIGR04047 141 AVLCVSAAWAAELRAEWGIDATV--VPNGVDAARFSPAADAadaaLRRRLGLRGGPYVLAVGGIEPRKNTIDLLEAFALL 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 271 KMLPEDMHLVMVG---------------QCYKDTEIPPSITHIPYIQGAEELAKVYSAADVYVHLSVEDTFGKVIAEAMA 335
Cdd:TIGR04047 219 RARRPQAQLVIAGgatlfdydayrrefrARAAELGVDPGPVVITGPVPDADLPALYRCADAFAFPSLKEGFGLVVLEALA 298

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1391517522 336 CGTPSIVFDSTACPELIGNNCGYVVRPHNVsDIIAKA 372
Cdd:TIGR04047 299 SGIPVVASDIAPFTEYLGRFDAAWADPSDP-DSIADA 334
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 305-371 1.16e-06

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 50.31  E-value: 1.16e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391517522 305 EELAKVYSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACP-ELIGNNC-GYVVRPHNVSDIIAK 371
Cdd:cd03820   247 KNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCPTGPsEIIEDGEnGLLVPNGDVDALAEA 315
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 293-344 6.36e-05

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 44.58  E-value: 6.36e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1391517522 293 PSITHIPYiQGAEELAKVYSAADVYVHLSVEDtFGKVIAEAMACGTPSIVFD 344
Cdd:cd03804   246 PNVEFLGY-QPDEVLKELLSKARAFVFAAEED-FGIVPVEAQACGTPVIAFG 295
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 301-372 1.67e-04

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 43.55  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1391517522 301 IQGaEELAKVYSAADVYVHLSVEDTFGKVIAEAMACGTPSIVFDSTACPELI----GNNCGYVVRPHNVSDIIAKA 372
Cdd:PLN02871  320 LQG-DELSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVAARAGGIPDIIppdqEGKTGFLYTPGDVDDCVEKL 394
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 305-399 5.42e-04

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 41.88  E-value: 5.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 305 EELAKVYSAADVYVHLSVEDT--FGKVIAEAMACGTPSIvfdSTACPE---LIGNN--CGYVVRPHNVSDIIAKANIIKK 377
Cdd:cd03795   253 EEKVIYLHLCDVFVFPSVLRSeaFGIVLLEAMMCGKPVI---STNIGTgvpYVNNNgeTGLVVPPKDPDALAEAIDKLLS 329

                          90       100
                  ....*....|....*....|....
gi 1391517522 378 NGKKY--FSTPAINYVKENFDYER 399
Cdd:cd03795   330 DEELResYGENAKKRFEELFTAEK 353
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
208-339 1.07e-03

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 40.68  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 208 SRSFLSKY------PVSYIYNWVDYKKFFPQPEDIRKKYQIpedkfillsVSAGwnkntSRYKDAMELMKML---PEDMH 278
Cdd:COG4641   100 DGDCVEEYralgarRVFYLPFAADPELHRPVPPEARFRYDV---------AFVG-----NYYPDRRARLEELllaPAGLR 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391517522 279 LVMVGQCYKDTEIPPSITHIPYIQGaEELAKVYSAADVYVHL-SVED--------TFgkviaEAMACGTP 339
Cdd:COG4641   166 LKIYGPGWPKLALPANVRRGGHLPG-EEHPAAYASSKITLNVnRMAAspdsptrrTF-----EAAACGAF 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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