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Conserved domains on  [gi|1396252908|gb|PXI64417|]
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HdeB family protein [Klebsiella pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HdeA super family cl05752
HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical ...
 5-92 1.18e-12

HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localized in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS. This family also contains HdeB.


The actual alignment was detected with superfamily member PRK11566:

Pssm-ID: 446773  Cd Length: 102  Bit Score: 58.66  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396252908   5 TVLAMSSAAVGKDVVPDEARTRDMMrCQDYLQLDPRAWTPMVIWLMNDPFSLEPPEWTDFHEAELVLTPILTEICRQEPD 84
Cdd:PRK11566    8 AAVTALSLVNAQSATATNTTPKDMT-CQEFIDLNPKSMTPVAFWVLNEDTDYKGGDYVDLNETDTTQVPKVIEYCKKNPQ 86


                  ....*...
gi 1396252908  85 VWLTSLRE 92
Cdd:PRK11566   87 KKLSTIKN 94
 
Name Accession Description Interval E-value
hdeB PRK11566
acid-activated periplasmic chaperone HdeB;
5-92 1.18e-12

acid-activated periplasmic chaperone HdeB;


Pssm-ID: 183204  Cd Length: 102  Bit Score: 58.66  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396252908   5 TVLAMSSAAVGKDVVPDEARTRDMMrCQDYLQLDPRAWTPMVIWLMNDPFSLEPPEWTDFHEAELVLTPILTEICRQEPD 84
Cdd:PRK11566    8 AAVTALSLVNAQSATATNTTPKDMT-CQEFIDLNPKSMTPVAFWVLNEDTDYKGGDYVDLNETDTTQVPKVIEYCKKNPQ 86


                  ....*...
gi 1396252908  85 VWLTSLRE 92
Cdd:PRK11566   87 KKLSTIKN 94
HdeA pfam06411
HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical ...
 1-89 1.14e-07

HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localized in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS. This family also contains HdeB.


Pssm-ID: 428923  Cd Length: 92  Bit Score: 45.45  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396252908   1 MAGITVLAMSSAAVGKDVVPDEARTRDMMRCQDYLQLDPRAWTPMVIWLMNDPFSLEPPEWTDFHEAELVLTPILTEICR 80
Cdd:pfam06411   4 LAAAALAAFSSSAMAQTASATPKKDLSKMTCEDFLDLDEEFKPPVIYWAEGYNSKGKPGDAVIDIEGIEKVTPKVVDYCK 83


                  ....*....
gi 1396252908  81 QEPDVWLTS 89
Cdd:pfam06411  84 KNPKASLMD 92
 
Name Accession Description Interval E-value
hdeB PRK11566
acid-activated periplasmic chaperone HdeB;
5-92 1.18e-12

acid-activated periplasmic chaperone HdeB;


Pssm-ID: 183204  Cd Length: 102  Bit Score: 58.66  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396252908   5 TVLAMSSAAVGKDVVPDEARTRDMMrCQDYLQLDPRAWTPMVIWLMNDPFSLEPPEWTDFHEAELVLTPILTEICRQEPD 84
Cdd:PRK11566    8 AAVTALSLVNAQSATATNTTPKDMT-CQEFIDLNPKSMTPVAFWVLNEDTDYKGGDYVDLNETDTTQVPKVIEYCKKNPQ 86


                  ....*...
gi 1396252908  85 VWLTSLRE 92
Cdd:PRK11566   87 KKLSTIKN 94
HdeA pfam06411
HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical ...
 1-89 1.14e-07

HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localized in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS. This family also contains HdeB.


Pssm-ID: 428923  Cd Length: 92  Bit Score: 45.45  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396252908   1 MAGITVLAMSSAAVGKDVVPDEARTRDMMRCQDYLQLDPRAWTPMVIWLMNDPFSLEPPEWTDFHEAELVLTPILTEICR 80
Cdd:pfam06411   4 LAAAALAAFSSSAMAQTASATPKKDLSKMTCEDFLDLDEEFKPPVIYWAEGYNSKGKPGDAVIDIEGIEKVTPKVVDYCK 83


                  ....*....
gi 1396252908  81 QEPDVWLTS 89
Cdd:pfam06411  84 KNPKASLMD 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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