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Conserved domains on  [gi|1398711228|gb|PYA04551|]
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class I adenylate cyclase [Serratia marcescens]

Protein Classification

class I adenylate cyclase( domain architecture ID 11459653)

class I adenylate cyclase catalyzes the conversion of ATP to cyclic AMP and pyrophosphate

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-830 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


:

Pssm-ID: 442306  Cd Length: 930  Bit Score: 1445.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228   1 MYLYIETLKQRLDAINQLRVDRALAAMKPAFQRVYSLLPTLLHHHHPLMPGYLNGNVPHGICLYTPDETQQDYLNDLEDk 80
Cdd:COG3072     7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRLAR- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228  81 wGSPFDKPASGELPITGVYSMGSTSSIGQSCSSDLDIWVCHQSWLDNEERTRLQQKCSLLEKWAASMGVEVSFFLIDENR 160
Cdd:COG3072    86 -SFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPGEEEAHYDEYVLSLYAQGALTPNEWLDLGGLSSLSA 240
Cdd:COG3072   165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTQLLATDIKHRLHQGEIVSFGLDAYCMMLERVTRYLTDINDTP 320
Cdd:COG3072   245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 321 RLDLARRCFYLKVCEKLSLAK--ACVGWRREILSQLVSEWGWSEERLAMLDNRANWKIERVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072   325 RLELVRRCFYLKVNEKLSRPPreRSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSENDLTFIHVPVGRANRTGWYLYNQAPAMDSIVS 478
Cdd:COG3072   405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 479 HQPLEYNRYLNKLVAWAYFSGLRPPQPRLHIKSGN-LCDTAKLQELVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072   485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLHPGGsDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 558 LENDPTAAFRNQVVHFDFRKLDVFSFGQQQQCLVGSIDLLYRNSWNEVRTLHFSGEQSVLEALKTILGKMHQDAAPPESV 637
Cdd:COG3072   565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 638 EVFCYSQHLRGLIRTRIQQLVSECIELRLSSTRLePGRFKAVRVAGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHG 717
Cdd:COG3072   645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 718 LSIKVE---TDQVHLPPVVDGFASEGIIQFFFEDTsdDKGFNIYILDESNRVEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072   724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDN--GDGFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                         810       820       830
                  ....*....|....*....|....*....|....*..
gi 1398711228 795 TYGSSFINFNLPQFYQIVQLD-GRTQVIPFRSNVLSS 830
Cdd:COG3072   802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRSPLAAS 838
 
Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-830 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


Pssm-ID: 442306  Cd Length: 930  Bit Score: 1445.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228   1 MYLYIETLKQRLDAINQLRVDRALAAMKPAFQRVYSLLPTLLHHHHPLMPGYLNGNVPHGICLYTPDETQQDYLNDLEDk 80
Cdd:COG3072     7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRLAR- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228  81 wGSPFDKPASGELPITGVYSMGSTSSIGQSCSSDLDIWVCHQSWLDNEERTRLQQKCSLLEKWAASMGVEVSFFLIDENR 160
Cdd:COG3072    86 -SFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPGEEEAHYDEYVLSLYAQGALTPNEWLDLGGLSSLSA 240
Cdd:COG3072   165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTQLLATDIKHRLHQGEIVSFGLDAYCMMLERVTRYLTDINDTP 320
Cdd:COG3072   245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 321 RLDLARRCFYLKVCEKLSLAK--ACVGWRREILSQLVSEWGWSEERLAMLDNRANWKIERVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072   325 RLELVRRCFYLKVNEKLSRPPreRSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSENDLTFIHVPVGRANRTGWYLYNQAPAMDSIVS 478
Cdd:COG3072   405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 479 HQPLEYNRYLNKLVAWAYFSGLRPPQPRLHIKSGN-LCDTAKLQELVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072   485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLHPGGsDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 558 LENDPTAAFRNQVVHFDFRKLDVFSFGQQQQCLVGSIDLLYRNSWNEVRTLHFSGEQSVLEALKTILGKMHQDAAPPESV 637
Cdd:COG3072   565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 638 EVFCYSQHLRGLIRTRIQQLVSECIELRLSSTRLePGRFKAVRVAGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHG 717
Cdd:COG3072   645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 718 LSIKVE---TDQVHLPPVVDGFASEGIIQFFFEDTsdDKGFNIYILDESNRVEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072   724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDN--GDGFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                         810       820       830
                  ....*....|....*....|....*....|....*..
gi 1398711228 795 TYGSSFINFNLPQFYQIVQLD-GRTQVIPFRSNVLSS 830
Cdd:COG3072   802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRSPLAAS 838
cyaA PRK09450
class I adenylate cyclase;
1-832 0e+00

class I adenylate cyclase;


Pssm-ID: 236522 [Multi-domain]  Cd Length: 830  Bit Score: 1427.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228   1 MYLYIETLKQRLDAINQLRVDRALAAMKPAFQRVYSLLPTLLHHHHPLMPGYLNGNVPHGICLYTPDETQQDYLNDLEDK 80
Cdd:PRK09450    1 MRKYLETLKQRLDALNQLRLARALAALSPAFQQVLSLLPLLLHVNHPLLPGYVSGNTPAGICNFTPDETQLAYLQRLELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228  81 WGSPFDKPASGELPITGVYSMGSTSSIGQSCSSDLDIWVCHQSWLDNEERTRLQQKCSLLEKWAASMGVEVSFFLIDENR 160
Cdd:PRK09450   81 FGYSVQDPPKGELPITGLYTMGSTGSIGQSESSDLDIWVCHRPWLDAEERQLLQRKCSLLEQWAASLGVEVNFFLMDEER 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 161 FRHNESGS-LGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPGEEEAHYDEYVLSLYAQGALTPNEWLDLGGLSSLS 239
Cdd:PRK09450  161 FRHNESGSaLGGEDCGSTQHILLLDEFYRTAIRLAGKRPLWWLVPVEEEEHYDDYVMTLYSKGFLNPNEWLDLGGLSSLP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 240 AEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTQLLATDIKHRLHQGEIVSFGLDAYCMMLERVTRYLTDINDT 319
Cdd:PRK09450  241 AEEYFGASLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLDFKQRLLAGEIDSDGLDPYCLMLERVTRYLTAINDP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 320 PRLDLARRCFYLKVCEKLSLAKACVGWRREILSQLVSEWGWSEERLAMLDNRANWKIERVREAHNELLDAMMQSYRNLIR 399
Cdd:PRK09450  321 TRLELVRRCFYLKVGEKLSRERACVGWRRELLSQLVSEWGWDEERLALLDNRANWKIGQVREFHNELVDALMQSYRNLIR 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 400 FARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSENDLTFIHVPVGRANRTGWYLYNQAPAMDSIVSH 479
Cdd:PRK09450  401 FARRNNLSSSISPQDIGILTRKLYAAFERLPGKVTLLNPQISPDLSEPDLTFIEVPPGRANRSGWYLYNQAPDPDSIIGH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 480 QPLEYNRYLNKLVAWAYFSGLRPPQPRLHIKSGNL-CDTAKLQELVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNL 558
Cdd:PRK09450  481 QPLEYNRYLNKLVAWAYFNGLLTSSTRLHLKGNGSdLDLAKLQELVADLRQHFPLRLPAPTPQALLQPCEIRHLLIIVNL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 559 ENDPTAAFRNQVVHFDFRKLDVFSFGQQQQCLVGSIDLLYRNSWNEVRTLHFSGEQSVLEALKTILGKMHQDAAPPESVE 638
Cdd:PRK09450  561 EVDPTAHLRGQVVHFDFRNLDVFSFGGEQENLVGSVDLIYRNSWNEVRTLHFEGEQALLDALKTILGKMHQDAAPPPSVE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 639 VFCYSQHLRGLIRTRIQQLVSECIELRLSSTRLEPGrfKAVRVAGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHGL 718
Cdd:PRK09450  641 VFCYSQHLRGLIRTRVQQLVSECIELRLGSTRQEPG--KALRVAGQTWGLFFERLGVSVQKLENAVEFYGALSENKLHGL 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 719 SIKVETDQVHLPPVVDGFASEGIIQFFFEDTSDdkGFNIYILDESNRVEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 798
Cdd:PRK09450  719 PVQLDTNFLKLPAVVDGFASEGIIQFFFEDNED--GFNVYILDESNRLEHYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 796
                         810       820       830
                  ....*....|....*....|....*....|....
gi 1398711228 799 SFINFNLPQFYQIVQLDGRTQVIPFRSNVLSSLC 832
Cdd:PRK09450  797 SFINFNLPQFYQLVRVDGRLQVIPFRSQLEEALN 830
Adenylate_cycl pfam01295
Adenylate cyclase, class-I;
228-825 0e+00

Adenylate cyclase, class-I;


Pssm-ID: 426186  Cd Length: 601  Bit Score: 965.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 228 EWLDLGGLSSLSAEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTQLLATDIKHRLHQGEIVSFGLDAYCMMLE 307
Cdd:pfam01295   1 DWLDLGGLSALPAEEYFGASLWQLYKGIDSPYKAVLKILLLEAYSSEYPNTELLSSQFKRRLLAGDFTSYHLDPYLLMLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 308 RVTRYLTDINDTPRLDLARRCFYLKVCEKLSLAK--ACVGWRREILSQLVSEWGWSEERLAMLDNRANWKIERVREAHNE 385
Cdd:pfam01295  81 RVTDYLTKINDFKRLDLVRRCFYLKAGEGLSRLQpnGAKDWRRDKLQELVQQWHWSDELIQTLDNRRHWKVGQVKWANNQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 386 LLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSENDLTFIHVPVGRANRTGWY 465
Cdd:pfam01295 161 LLELLMLSYRNLIQFARKHNISESISPEDIGILTRKLYTAFEELPGKVTLLNPLISPDLSEPDLTFIEVPEGRSNKAGWY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 466 LYNQAPAMDSIVSHQPLEYNRYLNKLVAWAYFSGLRPPQPRLHIKSGNL-CDTAKLQELVADVSHHFPLRLPAPTPKALY 544
Cdd:pfam01295 241 LYNQPPDPADLIGRRPLEYAKYLSKLVAWAYFNGLLTESTRLHLVSQGVdLTSDKLSQFVTDLRLSFPVRAPKPTNQDLS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 545 SPCEIRHLAIIVNLENDPTAAFRNQVVHFDFRKLDVFSFGQQQQCLVGSIDLLYRNSWNEVRTLHFSGEQSVLEALKTIL 624
Cdd:pfam01295 321 HPCEIRHLVIFINLEQDPTTHWSGQEVMVDIQNADLFSFGRSQENLVGSVDLIYRNSWNEIRTLHFEGENALLKALKTIL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 625 GKMHQDAAPPESVEVFCYSQHLRGLIRTRIQQLVSECIELRLsSTRLEPGRFKAVRVAGQTWGLFFERLSVSVQKLENAV 704
Cdd:pfam01295 401 NKIHRDAAPPESIDVFCYSRRLRSQLRNAVKQLLNRCIELRL-GTIQSRTQVKPLRIGGKNYGLFFERRGVSVQDLENAV 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 705 EFYGAISNNKLHGLSIKV--ETDQVHLPPVVDGFASEGIIQFFFEDTSDdkGFNIYILDESNRVEVYHHCEGSKEELVRD 782
Cdd:pfam01295 480 DFYGQISRNKLVELPRPElgDDPFLHIPAIIDAFASEGLIQFFFEDNED--GFNVYILDEKNELEIYHQCDGSKDELVNE 557
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 1398711228 783 VSRFYSSSHDRFTYGSSFINFNLPQFYQIVQLDGRTQVIPFRS 825
Cdd:pfam01295 558 VNRFYASSESRKNTNPAFINFNLPQFYQLVRVNGELKVVPFRS 600
 
Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-830 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


Pssm-ID: 442306  Cd Length: 930  Bit Score: 1445.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228   1 MYLYIETLKQRLDAINQLRVDRALAAMKPAFQRVYSLLPTLLHHHHPLMPGYLNGNVPHGICLYTPDETQQDYLNDLEDk 80
Cdd:COG3072     7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRLAR- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228  81 wGSPFDKPASGELPITGVYSMGSTSSIGQSCSSDLDIWVCHQSWLDNEERTRLQQKCSLLEKWAASMGVEVSFFLIDENR 160
Cdd:COG3072    86 -SFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPGEEEAHYDEYVLSLYAQGALTPNEWLDLGGLSSLSA 240
Cdd:COG3072   165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTQLLATDIKHRLHQGEIVSFGLDAYCMMLERVTRYLTDINDTP 320
Cdd:COG3072   245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 321 RLDLARRCFYLKVCEKLSLAK--ACVGWRREILSQLVSEWGWSEERLAMLDNRANWKIERVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072   325 RLELVRRCFYLKVNEKLSRPPreRSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSENDLTFIHVPVGRANRTGWYLYNQAPAMDSIVS 478
Cdd:COG3072   405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 479 HQPLEYNRYLNKLVAWAYFSGLRPPQPRLHIKSGN-LCDTAKLQELVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072   485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLHPGGsDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 558 LENDPTAAFRNQVVHFDFRKLDVFSFGQQQQCLVGSIDLLYRNSWNEVRTLHFSGEQSVLEALKTILGKMHQDAAPPESV 637
Cdd:COG3072   565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 638 EVFCYSQHLRGLIRTRIQQLVSECIELRLSSTRLePGRFKAVRVAGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHG 717
Cdd:COG3072   645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 718 LSIKVE---TDQVHLPPVVDGFASEGIIQFFFEDTsdDKGFNIYILDESNRVEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072   724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDN--GDGFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                         810       820       830
                  ....*....|....*....|....*....|....*..
gi 1398711228 795 TYGSSFINFNLPQFYQIVQLD-GRTQVIPFRSNVLSS 830
Cdd:COG3072   802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRSPLAAS 838
cyaA PRK09450
class I adenylate cyclase;
1-832 0e+00

class I adenylate cyclase;


Pssm-ID: 236522 [Multi-domain]  Cd Length: 830  Bit Score: 1427.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228   1 MYLYIETLKQRLDAINQLRVDRALAAMKPAFQRVYSLLPTLLHHHHPLMPGYLNGNVPHGICLYTPDETQQDYLNDLEDK 80
Cdd:PRK09450    1 MRKYLETLKQRLDALNQLRLARALAALSPAFQQVLSLLPLLLHVNHPLLPGYVSGNTPAGICNFTPDETQLAYLQRLELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228  81 WGSPFDKPASGELPITGVYSMGSTSSIGQSCSSDLDIWVCHQSWLDNEERTRLQQKCSLLEKWAASMGVEVSFFLIDENR 160
Cdd:PRK09450   81 FGYSVQDPPKGELPITGLYTMGSTGSIGQSESSDLDIWVCHRPWLDAEERQLLQRKCSLLEQWAASLGVEVNFFLMDEER 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 161 FRHNESGS-LGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPGEEEAHYDEYVLSLYAQGALTPNEWLDLGGLSSLS 239
Cdd:PRK09450  161 FRHNESGSaLGGEDCGSTQHILLLDEFYRTAIRLAGKRPLWWLVPVEEEEHYDDYVMTLYSKGFLNPNEWLDLGGLSSLP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 240 AEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTQLLATDIKHRLHQGEIVSFGLDAYCMMLERVTRYLTDINDT 319
Cdd:PRK09450  241 AEEYFGASLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLDFKQRLLAGEIDSDGLDPYCLMLERVTRYLTAINDP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 320 PRLDLARRCFYLKVCEKLSLAKACVGWRREILSQLVSEWGWSEERLAMLDNRANWKIERVREAHNELLDAMMQSYRNLIR 399
Cdd:PRK09450  321 TRLELVRRCFYLKVGEKLSRERACVGWRRELLSQLVSEWGWDEERLALLDNRANWKIGQVREFHNELVDALMQSYRNLIR 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 400 FARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSENDLTFIHVPVGRANRTGWYLYNQAPAMDSIVSH 479
Cdd:PRK09450  401 FARRNNLSSSISPQDIGILTRKLYAAFERLPGKVTLLNPQISPDLSEPDLTFIEVPPGRANRSGWYLYNQAPDPDSIIGH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 480 QPLEYNRYLNKLVAWAYFSGLRPPQPRLHIKSGNL-CDTAKLQELVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNL 558
Cdd:PRK09450  481 QPLEYNRYLNKLVAWAYFNGLLTSSTRLHLKGNGSdLDLAKLQELVADLRQHFPLRLPAPTPQALLQPCEIRHLLIIVNL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 559 ENDPTAAFRNQVVHFDFRKLDVFSFGQQQQCLVGSIDLLYRNSWNEVRTLHFSGEQSVLEALKTILGKMHQDAAPPESVE 638
Cdd:PRK09450  561 EVDPTAHLRGQVVHFDFRNLDVFSFGGEQENLVGSVDLIYRNSWNEVRTLHFEGEQALLDALKTILGKMHQDAAPPPSVE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 639 VFCYSQHLRGLIRTRIQQLVSECIELRLSSTRLEPGrfKAVRVAGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHGL 718
Cdd:PRK09450  641 VFCYSQHLRGLIRTRVQQLVSECIELRLGSTRQEPG--KALRVAGQTWGLFFERLGVSVQKLENAVEFYGALSENKLHGL 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 719 SIKVETDQVHLPPVVDGFASEGIIQFFFEDTSDdkGFNIYILDESNRVEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 798
Cdd:PRK09450  719 PVQLDTNFLKLPAVVDGFASEGIIQFFFEDNED--GFNVYILDESNRLEHYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 796
                         810       820       830
                  ....*....|....*....|....*....|....
gi 1398711228 799 SFINFNLPQFYQIVQLDGRTQVIPFRSNVLSSLC 832
Cdd:PRK09450  797 SFINFNLPQFYQLVRVDGRLQVIPFRSQLEEALN 830
Adenylate_cycl pfam01295
Adenylate cyclase, class-I;
228-825 0e+00

Adenylate cyclase, class-I;


Pssm-ID: 426186  Cd Length: 601  Bit Score: 965.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 228 EWLDLGGLSSLSAEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTQLLATDIKHRLHQGEIVSFGLDAYCMMLE 307
Cdd:pfam01295   1 DWLDLGGLSALPAEEYFGASLWQLYKGIDSPYKAVLKILLLEAYSSEYPNTELLSSQFKRRLLAGDFTSYHLDPYLLMLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 308 RVTRYLTDINDTPRLDLARRCFYLKVCEKLSLAK--ACVGWRREILSQLVSEWGWSEERLAMLDNRANWKIERVREAHNE 385
Cdd:pfam01295  81 RVTDYLTKINDFKRLDLVRRCFYLKAGEGLSRLQpnGAKDWRRDKLQELVQQWHWSDELIQTLDNRRHWKVGQVKWANNQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 386 LLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSENDLTFIHVPVGRANRTGWY 465
Cdd:pfam01295 161 LLELLMLSYRNLIQFARKHNISESISPEDIGILTRKLYTAFEELPGKVTLLNPLISPDLSEPDLTFIEVPEGRSNKAGWY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 466 LYNQAPAMDSIVSHQPLEYNRYLNKLVAWAYFSGLRPPQPRLHIKSGNL-CDTAKLQELVADVSHHFPLRLPAPTPKALY 544
Cdd:pfam01295 241 LYNQPPDPADLIGRRPLEYAKYLSKLVAWAYFNGLLTESTRLHLVSQGVdLTSDKLSQFVTDLRLSFPVRAPKPTNQDLS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 545 SPCEIRHLAIIVNLENDPTAAFRNQVVHFDFRKLDVFSFGQQQQCLVGSIDLLYRNSWNEVRTLHFSGEQSVLEALKTIL 624
Cdd:pfam01295 321 HPCEIRHLVIFINLEQDPTTHWSGQEVMVDIQNADLFSFGRSQENLVGSVDLIYRNSWNEIRTLHFEGENALLKALKTIL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 625 GKMHQDAAPPESVEVFCYSQHLRGLIRTRIQQLVSECIELRLsSTRLEPGRFKAVRVAGQTWGLFFERLSVSVQKLENAV 704
Cdd:pfam01295 401 NKIHRDAAPPESIDVFCYSRRLRSQLRNAVKQLLNRCIELRL-GTIQSRTQVKPLRIGGKNYGLFFERRGVSVQDLENAV 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228 705 EFYGAISNNKLHGLSIKV--ETDQVHLPPVVDGFASEGIIQFFFEDTSDdkGFNIYILDESNRVEVYHHCEGSKEELVRD 782
Cdd:pfam01295 480 DFYGQISRNKLVELPRPElgDDPFLHIPAIIDAFASEGLIQFFFEDNED--GFNVYILDEKNELEIYHQCDGSKDELVNE 557
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 1398711228 783 VSRFYSSSHDRFTYGSSFINFNLPQFYQIVQLDGRTQVIPFRS 825
Cdd:pfam01295 558 VNRFYASSESRKNTNPAFINFNLPQFYQLVRVNGELKVVPFRS 600
Adenyl_cycl_N pfam12633
Adenylate cyclase NT domain;
4-200 7.28e-98

Adenylate cyclase NT domain;


Pssm-ID: 432684 [Multi-domain]  Cd Length: 198  Bit Score: 303.33  E-value: 7.28e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228   4 YIETLKQRLDAINQLRVDRALAAMKPAFQRVYSLLPTLLHHHHPLMPGYLNGNVPHGICLYTPDETQQDYLNDLEDKWGS 83
Cdd:pfam12633   1 DLETLRQRFDALNQLRLERALAALSPRQQQVLRLLPLLLHVNHPLLPGYVSGDTPCGIANFEPSKFQLALLDRLFRSFTY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398711228  84 PFDKPASGELPITGVYSMGSTSSIGQSCSSDLDIWVCHQSWLDNEERTRLQQKCSLLEKWAASMGVEVSFFLIDENRFRH 163
Cdd:pfam12633  81 KETKTDISDPPILGLYLMGSTGSIAQSASSDLDIWVCHRPGLDAEELELLQRKCQLIEQWAAQFGVEVHFFLMDPERFRS 160
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1398711228 164 NESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILW 200
Cdd:pfam12633 161 NRSSSLTEESSGSAQHLLLLDEFYRTAIRLAGKRPLW 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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