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Conserved domains on  [gi|1404840570|gb|PZO80440|]
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hypothetical protein DI632_02435 [Sphingomonas hengshuiensis]

Protein Classification

Bax inhibitor-1/YccA family protein( domain architecture ID 10179639)

Bax inhibitor-1/YccA family protein similar to Escherichia coli YccA, which negatively regulates the FtsH protease and is degraded by in an FtsH-dependent manner

Gene Ontology:  GO:0016020
PubMed:  18336295|18440869
TCDB:  1.A.14.2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 27-243 1.58e-69

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


:

Pssm-ID: 198414  Cd Length: 211  Bit Score: 212.42  E-value: 1.58e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  27 GLRSYMLSVYNYMASGVLLTGIVALLFSWggdtsMAAQVFYQPGLLKYAIMFSPLIFVMVLSFGINRLSTGAAQGLFWAF 106
Cdd:cd10432     1 GLRSFMKKVYGLMAAGLLLTAVGAYVGAS-----TPALLLIAGSPLMWVLLIAELALVFGLSFRINKMSVATALPLFFAF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 107 AAIMGLSMSTIFLRYTGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGMMSLIISA 186
Cdd:cd10432    76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1404840570 187 IGVLLFAGLTAYDTQRIKGLYYQvAGTDFAGKAVIMGALSLYLDFVNMFQFLLSFLG 243
Cdd:cd10432   156 IGVLIFSGLIAYDTQRIKRMYEA-GGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
 
Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 27-243 1.58e-69

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 212.42  E-value: 1.58e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  27 GLRSYMLSVYNYMASGVLLTGIVALLFSWggdtsMAAQVFYQPGLLKYAIMFSPLIFVMVLSFGINRLSTGAAQGLFWAF 106
Cdd:cd10432     1 GLRSFMKKVYGLMAAGLLLTAVGAYVGAS-----TPALLLIAGSPLMWVLLIAELALVFGLSFRINKMSVATALPLFFAF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 107 AAIMGLSMSTIFLRYTGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGMMSLIISA 186
Cdd:cd10432    76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1404840570 187 IGVLLFAGLTAYDTQRIKGLYYQvAGTDFAGKAVIMGALSLYLDFVNMFQFLLSFLG 243
Cdd:cd10432   156 IGVLIFSGLIAYDTQRIKRMYEA-GGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 15-246 1.18e-68

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 210.81  E-value: 1.18e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  15 TRTRDRDMARDEGLRSYMLSVYNYMASGVLLTGIVALLfswGGDTSMAAQVFYQPGLLKYAIMFSPLIFVMVLSFGINRL 94
Cdd:COG0670     6 RNAGAAAAASDAGLRKVLRNTYGLLALGLLLTALVAYL---GMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSKLANRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  95 STGAAQGLFWAFAAIMGLSMSTIFLRYTGP----SIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASL 170
Cdd:COG0670    83 NSAAALALLFAYTALMGLTLSPILLVYTGLsgpaSIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1404840570 171 LNLFFQSGMMSLIISAIGVLLFAGLTAYDTQRIKGLYYQvagtdfaGKAVIMGALSLYLDFVNMFQFLLSFLGSRD 246
Cdd:COG0670   163 VNIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYET-------NKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 29-242 7.09e-49

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 159.65  E-value: 7.09e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  29 RSYMLSVYNYMASGVLLTGIVAllfsWGGDTSMAAQVFYQPGLLKYAIMFSPLIFVMVLS--FGINRLSTGAAQGLFWAF 106
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVA----YLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALllARKRKYSSNVALLLLLAF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 107 AAIMGLSMSTIFLRYTGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGMMSLIISA 186
Cdd:pfam01027  77 TLLMGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1404840570 187 IGVLLFAGLTAYDTQRIKGLYYQVAGTDFagkavIMGALSLYLDFVNMFQFLLSFL 242
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYGEYGDYDA-----ILAALSLYLDFINLFLSLLRIL 207
PRK10447 PRK10447
FtsH protease modulator YccA;
104-243 1.46e-05

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 44.83  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 104 WAFAAIMGLSMSTIFLRY----TGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGM 179
Cdd:PRK10447   80 FAFTGFLGYILGPILNTYlsagMGDVIALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPA 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1404840570 180 MSLIISAIGVLLFAGLTAYDTQRIkglyYQVAGTDFagkavIMGALSLYLDFVNMFQFLLSFLG 243
Cdd:PRK10447  160 LHLAISAVFILISSGAILFETSNI----IHGGETNY-----IRATVSLYVSLYNIFVSLLSILG 214
 
Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 27-243 1.58e-69

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 212.42  E-value: 1.58e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  27 GLRSYMLSVYNYMASGVLLTGIVALLFSWggdtsMAAQVFYQPGLLKYAIMFSPLIFVMVLSFGINRLSTGAAQGLFWAF 106
Cdd:cd10432     1 GLRSFMKKVYGLMAAGLLLTAVGAYVGAS-----TPALLLIAGSPLMWVLLIAELALVFGLSFRINKMSVATALPLFFAF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 107 AAIMGLSMSTIFLRYTGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGMMSLIISA 186
Cdd:cd10432    76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1404840570 187 IGVLLFAGLTAYDTQRIKGLYYQvAGTDFAGKAVIMGALSLYLDFVNMFQFLLSFLG 243
Cdd:cd10432   156 IGVLIFSGLIAYDTQRIKRMYEA-GGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 15-246 1.18e-68

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 210.81  E-value: 1.18e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  15 TRTRDRDMARDEGLRSYMLSVYNYMASGVLLTGIVALLfswGGDTSMAAQVFYQPGLLKYAIMFSPLIFVMVLSFGINRL 94
Cdd:COG0670     6 RNAGAAAAASDAGLRKVLRNTYGLLALGLLLTALVAYL---GMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSKLANRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  95 STGAAQGLFWAFAAIMGLSMSTIFLRYTGP----SIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASL 170
Cdd:COG0670    83 NSAAALALLFAYTALMGLTLSPILLVYTGLsgpaSIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1404840570 171 LNLFFQSGMMSLIISAIGVLLFAGLTAYDTQRIKGLYYQvagtdfaGKAVIMGALSLYLDFVNMFQFLLSFLGSRD 246
Cdd:COG0670   163 VNIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYET-------NKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 29-242 7.09e-49

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 159.65  E-value: 7.09e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  29 RSYMLSVYNYMASGVLLTGIVAllfsWGGDTSMAAQVFYQPGLLKYAIMFSPLIFVMVLS--FGINRLSTGAAQGLFWAF 106
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVA----YLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALllARKRKYSSNVALLLLLAF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 107 AAIMGLSMSTIFLRYTGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGMMSLIISA 186
Cdd:pfam01027  77 TLLMGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1404840570 187 IGVLLFAGLTAYDTQRIKGLYYQVAGTDFagkavIMGALSLYLDFVNMFQFLLSFL 242
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYGEYGDYDA-----ILAALSLYLDFINLFLSLLRIL 207
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 35-246 4.74e-19

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 82.65  E-value: 4.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  35 VYNYMASGVLLTGIVALLFSwggdTSMAAQVFYQ--PGLLkYAIMFSPLIFVMVLSFgiNRLSTGAAQGLFWAFAAIMGL 112
Cdd:cd10429    34 VYSILSVQLLATTAVSALFY----LSPSIKTFVQshPWLF-LISLIGSLILLIALYW--KRHSHPVNLILLSLFTLCEAY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 113 SMSTIFLRYTGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFF-QSGMMSLIISAIGVLL 191
Cdd:cd10429   107 TVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILLALIFQFFpYSPTFELVYAGLGALL 186

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1404840570 192 FAGLTAYDTQRI-KGLYYQVAgtdfagkavIMGALSLYLDFVNMFQFLLSFLGSRD 246
Cdd:cd10429   187 FSGYIVYDTQLImKRLSPDEY---------ILAAISLYLDIINLFLSILRILAAMN 233
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 81-244 5.86e-17

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 76.47  E-value: 5.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  81 LIFVMVLSFGINRLSTGAAqGLFWAFA--AIMGLSMSTIFLRYT----GPSIALTFFATTAA-FLSLSLYGYTTKRDLTG 153
Cdd:cd10433    42 LVGAYGLLFLIEKTRNSAW-GIVLVFAftGFMGYTLGPILNMYLalpnGGQIIMTALGGTAAiFFGLSAYALTTKKDFSF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 154 FGTFLIMGLVGLIVASLLNLFFQSGMMSLIISAIGVLLFAGLTAYDTQRIkglyyqVAGTDfagKAVIMGALSLYLDFVN 233
Cdd:cd10433   121 LGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFILYDTSRI------IHGGE---TNYIMATVSLYVSIYN 191

                         170
                  ....*....|.
gi 1404840570 234 MFQFLLSFLGS 244
Cdd:cd10433   192 LFVSLLNLLGA 202
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 29-243 1.03e-13

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 67.82  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570  29 RSYMLSVYNYMASGVLLTGIVALLFSWGGDTSMAAQVFYQPGLLKYAIMFSPLIfvmvlsfgiNRLSTGAAQGLFWAFAA 108
Cdd:cd06181     3 KDFLRKVYMILALQLLLTAATATAFTVCDPGWYWSPALMGLLTSMLALMATAAM---------IRAKMPVNLILLFGFTG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 109 IMGLSMSTIFLRYTGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGMMSLIISAIG 188
Cdd:cd06181    74 LMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAVG 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1404840570 189 VLLFAGLTAYDTQRIkglyyqVAGTDFAGKAVIMGALSLYLDFVNMFQFLLSFLG 243
Cdd:cd06181   154 LVLFCGFLLYDTQLI------IHKAEVGPEDYINACISLYLDIINIFIRLLTILA 202
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 106-243 1.47e-12

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 64.48  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 106 FAAIMGLSMSTIFLRYTGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGMMSLIIS 185
Cdd:cd10428    84 FTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHIVYA 163

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1404840570 186 AIGVLLFAGLTAYDTQRI-KGLYYQVAGTDFagkavIMGALSLYLDFVNMFQFLLSFLG 243
Cdd:cd10428   164 SLGALLFSLYLAVDTQLLmGGRKYELSPEEY-----IFAALNIYVDIVNIFLYILQLIG 217
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 101-242 1.69e-06

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 47.22  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 101 GLFWAFAAIMGLSMSTIFLRYT--GPSIALT-FFATTAAFLSLSLYG-YTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQ 176
Cdd:cd10430    69 GLLLGFAFLTGASLGPLLDLVIaiNPSIIVTaFLGTAVIFACFSLAAlLAKRREYLYLGGLLSSALSILLLVSLANIFGG 148

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1404840570 177 SGMMSLIISAIGVLLFAGLTAYDTQRIkglyyqVAGTDFAGKAVIMGALSLYLDFVNMFQFLLSFL 242
Cdd:cd10430   149 SKFLFQAELYLGLLVFCGFVLFDTQMI------IEKAENGDRDYIWHALDLFVDFVALFRRLLIIL 208
PRK10447 PRK10447
FtsH protease modulator YccA;
104-243 1.46e-05

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 44.83  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1404840570 104 WAFAAIMGLSMSTIFLRY----TGPSIALTFFATTAAFLSLSLYGYTTKRDLTGFGTFLIMGLVGLIVASLLNLFFQSGM 179
Cdd:PRK10447   80 FAFTGFLGYILGPILNTYlsagMGDVIALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPA 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1404840570 180 MSLIISAIGVLLFAGLTAYDTQRIkglyYQVAGTDFagkavIMGALSLYLDFVNMFQFLLSFLG 243
Cdd:PRK10447  160 LHLAISAVFILISSGAILFETSNI----IHGGETNY-----IRATVSLYVSLYNIFVSLLSILG 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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