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Conserved domains on  [gi|548879|sp|Q01730|]
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RecName: Full=Ras suppressor protein 1; Short=RSP-1; Short=Rsu-1

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 2.82e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 2.82e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    34 NGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSSRLLEV 113
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879   114 LELTYNNLNEhsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886 187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                       170
                ....*....|..
gi 548879   194 VLPPELGNLDLT 205
Cdd:COG4886 264 DLPPLANLTNLK 275
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 2.82e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 2.82e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    34 NGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSSRLLEV 113
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879   114 LELTYNNLNEhsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886 187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                       170
                ....*....|..
gi 548879   194 VLPPELGNLDLT 205
Cdd:COG4886 264 DLPPLANLTNLK 275
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-200 2.52e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.80  E-value: 2.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     38 SLAHITQL---VLSHNKLT-TVPPNVAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSSRLL 111
Cdd:PLN00113 183 SLTNLTSLeflTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNL 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    112 EVLELtYNNLNEHSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQ 188
Cdd:PLN00113 263 QYLFL-YQNKLSGPIPPSIFSLQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLW 340

                        170
                 ....*....|...
gi 548879    189 GNRLT-VLPPELG 200
Cdd:PLN00113 341 SNKFSgEIPKNLG 353
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-174 6.37e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 6.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    35 GLFSLAHITQLVLSHNKLTTVpPNVAELKNLEVLNFFNNQIEELpTQISSLQKLKHLNLGMNRlntLPRG---------- 104
Cdd:cd21340  41 NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQR---LPPGekltfdprsl 115

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 548879   105 FGSSRLLEVLELTYNNLNEhslPGNFFYLTTLRALYLSDN---DFEILPPDIGKLTKLQILSLRDNDLISLPK 174
Cdd:cd21340 116 AALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
86-146 1.68e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 1.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 548879      86 QKLKHLNLGMNRLNTLPRG-FGSSRLLEVLELTYNNLNeHSLPGNFFYLTTLRALYLSDNDF 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 2.82e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 2.82e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    34 NGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSSRLLEV 113
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879   114 LELTYNNLNEhsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886 187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                       170
                ....*....|..
gi 548879   194 VLPPELGNLDLT 205
Cdd:COG4886 264 DLPPLANLTNLK 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-202 2.02e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 2.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    16 NQPEVDMSDRGISSMLDVNGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    96 NRLNTLPRGFGSSRLLEVLELTYNNLNEhslpgnFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKE 175
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                       170       180
                ....*....|....*....|....*..
gi 548879   176 IGELTQLKELHIQGNRLTVLPPELGNL 202
Cdd:COG4886 155 LGNLTNLKSLDLSNNQLTDLPEELGNL 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-200 2.52e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.80  E-value: 2.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     38 SLAHITQL---VLSHNKLT-TVPPNVAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSSRLL 111
Cdd:PLN00113 183 SLTNLTSLeflTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNL 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    112 EVLELtYNNLNEHSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQ 188
Cdd:PLN00113 263 QYLFL-YQNKLSGPIPPSIFSLQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLW 340

                        170
                 ....*....|...
gi 548879    189 GNRLT-VLPPELG 200
Cdd:PLN00113 341 SNKFSgEIPKNLG 353
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-217 5.13e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 5.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     31 LDVNGLFSLAH-----ITQLVLSHNKLTTVPPNVAelKNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370 185 LKILGLTTIPAcipeqITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    106 GSSrlLEVLELTYNNLN--EHSLPGNFFYL-------TTLRA--------LYLSDNDFEILPPDIGklTKLQILSLRDND 168
Cdd:PRK15370 261 PSA--LQSLDLFHNKISclPENLPEELRYLsvydnsiRTLPAhlpsgithLNVQSNSLTALPETLP--PGLKTLEAGENA 336

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 548879    169 LISLPKEIGelTQLKELHIQGNRLTV----LPPELGNLDLTGQKQVFKAENNP 217
Cdd:PRK15370 337 LTSLPASLP--PELQVLDVSKNQITVlpetLPPTITTLDVSRNALTNLPENLP 387
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
40-208 2.56e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 63.64  E-value: 2.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     40 AHITQLVLSHNKLTTVPPNVAELKNLEV-----------------LNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLP 102
Cdd:PRK15387 222 AHITTLVIPDNNLTSLPALPPELRTLEVsgnqltslpvlppglleLSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLP 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    103 RGfgssrlLEVLELTYNNLNehSLPGnffYLTTLRALYLSDNDFEILPPdigKLTKLQILSLRDNDLISLPKEIGELTQ- 181
Cdd:PRK15387 302 PG------LQELSVSDNQLA--SLPA---LPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKl 367

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 548879    182 ----------------LKELHIQGNRLT---VLPPELGNLDLTGQK 208
Cdd:PRK15387 368 waynnrltslpalpsgLKELIVSGNRLTslpVLPSELKELMVSGNR 413
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-217 5.56e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.79  E-value: 5.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     31 LDVNGLFSL-----AHITQLVLSHNKLTTVPPNVAElkNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370 248 LSINRITELperlpSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    106 GSSrlLEVLELTYNNLNehSLPGNFfyLTTLRALYLSDNDFEILPPDIGKltKLQILSLRDNDLISLPKEIGelTQLKEL 185
Cdd:PRK15370 324 PPG--LKTLEAGENALT--SLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLP--AALQIM 393

                        170       180       190
                 ....*....|....*....|....*....|...
gi 548879    186 HIQGNRLTVLPPELGNLDLTG-QKQVFKAENNP 217
Cdd:PRK15370 394 QASRNNLVRLPESLPHFRGEGpQPTRIIVEYNP 426
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-202 8.31e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 8.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     40 AHITQLVLSHNKLT-TVPPNVAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFGSsrLLEVLE 115
Cdd:PLN00113  69 SRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGSIP--NLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    116 LTyNNLNEHSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI------------------------ 170
Cdd:PLN00113 147 LS-NNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnls 225

                        170       180       190
                 ....*....|....*....|....*....|....
gi 548879    171 -SLPKEIGELTQLKELHIQGNRLT-VLPPELGNL 202
Cdd:PLN00113 226 gEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNL 259
PLN03150 PLN03150
hypothetical protein; Provisional
 58-217 1.50e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.29  E-value: 1.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     58 NVAELKNLEVLNFFNNQIEELPTQISSLQKLKH-----LNLGMNRLNTLPR---------GFGSSR---LLEVLELTYNN 120
Cdd:PLN03150 350 THAIINAIEVFEIITAESKTLLEEVSALQTLKSslglpLRFGWNGDPCVPQqhpwsgadcQFDSTKgkwFIDGLGLDNQG 429

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    121 LNEHsLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VLPP 197
Cdd:PLN03150 430 LRGF-IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPA 508

                        170       180
                 ....*....|....*....|
gi 548879    198 ELGNLDLTGQKqvFKAENNP 217
Cdd:PLN03150 509 ALGGRLLHRAS--FNFTDNA 526
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-200 6.10e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     32 DVNGLFSLAHitqLVLSHNKLT-TVPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSS 108
Cdd:PLN00113 231 EIGGLTSLNH---LDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQL 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    109 RLLEVLELTYNNLNeHSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLIS-LPKEIGELTQLKEL 185
Cdd:PLN00113 308 QNLEILHLFSNNFT-GKIPVALTSLPRLQVLQLWSNKFsgEI-PKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKL 385

                        170
                 ....*....|....*.
gi 548879    186 HIQGNRL-TVLPPELG 200
Cdd:PLN00113 386 ILFSNSLeGEIPKSLG 401
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-208 6.21e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 6.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     41 HITQLVLSHNKLT-TVPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSSRLLEVLELT 117
Cdd:PLN00113 357 NLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDIS 436

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    118 YNNLnEHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VL 195
Cdd:PLN00113 437 NNNL-QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEI 515

                        170
                 ....*....|....*....
gi 548879    196 PPELG------NLDLTGQK 208
Cdd:PLN00113 516 PDELSsckklvSLDLSHNQ 534
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-174 6.37e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 6.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    35 GLFSLAHITQLVLSHNKLTTVpPNVAELKNLEVLNFFNNQIEELpTQISSLQKLKHLNLGMNRlntLPRG---------- 104
Cdd:cd21340  41 NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQR---LPPGekltfdprsl 115

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 548879   105 FGSSRLLEVLELTYNNLNEhslPGNFFYLTTLRALYLSDN---DFEILPPDIGKLTKLQILSLRDNDLISLPK 174
Cdd:cd21340 116 AALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 39-206 2.25e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 2.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    39 LAHITQLVLSHNKLTTVPpNVAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSSRLLEVLELTY 118
Cdd:cd21340   1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879   119 NNLNEHSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHI 187
Cdd:cd21340  78 NRISVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDA 149

                       170       180
                ....*....|....*....|....*...
gi 548879   188 QGNRLTVLP---------PELGNLDLTG 206
Cdd:cd21340 150 SNNQISDLEelldllsswPSLRELDLTG 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-196 5.18e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 5.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    22 MSDRGISSMLDVNGLFSLAHitqLVLSHNKLTTVPpNVAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTL 101
Cdd:cd21340   9 LNDKNITKIDNLSLCKNLKV---LYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879   102 pRGFGSSRLLEVLELTYNNL-NEHSL---PGNFFYL-TTLRALYLSDNDFEILPPdIGKLTKLQILSLRDNDLISLPK-- 174
Cdd:cd21340  84 -EGLENLTNLEELHIENQRLpPGEKLtfdPRSLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEEll 161

                       170       180
                ....*....|....*....|...
gi 548879   175 -EIGELTQLKELHIQGNRLTVLP 196
Cdd:cd21340 162 dLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 11-170 3.20e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     11 ESREKNQPEVDMSDRGISSML-DVNGLFSLAHITQLVLSHNKLT-TVPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQK 87
Cdd:PLN00113 445 NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKK 524

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     88 LKHLNLGMNRLN-TLPRGFGSSRLLEVLELTYNNLNeHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRD 166
Cdd:PLN00113 525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAG 603


                 ....
gi 548879    167 NDLI 170
Cdd:PLN00113 604 NIDL 607
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
19-193 8.24e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 8.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     19 EVDMSDRGISSMLDVNglfslAHITQLVLSHNKLTTVPPNVAELKNLEVlnfFNNQIEELPTQISSLQKLKHLNLGMNRL 98
Cdd:PRK15387 306 ELSVSDNQLASLPALP-----SELCKLWAYNNQLTSLPTLPSGLQELSV---SDNQLASLPTLPSELYKLWAYNNRLTSL 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     99 NTLPRGfgssrlLEVLELTYNNLNehSLPgnfFYLTTLRALYLSDNDFEILP--PdigklTKLQILSLRDNDLISLPKEI 176
Cdd:PRK15387 378 PALPSG------LKELIVSGNRLT--SLP---VLPSELKELMVSGNRLTSLPmlP-----SGLLSLSVYRNQLTRLPESL 441

                        170
                 ....*....|....*..
gi 548879    177 GELTQLKELHIQGNRLT 193
Cdd:PRK15387 442 IHLSSETTVNLEGNPLS 458
LRR_8 pfam13855
Leucine rich repeat;
86-146 1.68e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 1.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 548879      86 QKLKHLNLGMNRLNTLPRG-FGSSRLLEVLELTYNNLNeHSLPGNFFYLTTLRALYLSDNDF 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
64-121 3.41e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 3.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879      64 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSSRLLEVLELTYNNL 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 5-210 6.16e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.01  E-value: 6.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879       5 LKKLVEESREKNQPEVDMSDRGISSMLDvnGLFSLAHITQLVLSHNKLTTVPPNVAELKNLEVLNFFN-NQIEELPTQIS 83
Cdd:PLN03210  601 LRCMPSNFRPENLVKLQMQGSKLEKLWD--GVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDcSSLVELPSSIQ 678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879      84 SLQKLKHLNL-GMNRLNTLPRGF-----------GSSRLLEVLELTYN----NLNEHS---LPGNFfYLTTLRALYLSDN 144
Cdd:PLN03210  679 YLNKLEDLDMsRCENLEILPTGInlkslyrlnlsGCSRLKSFPDISTNiswlDLDETAieeFPSNL-RLENLDELILCEM 757

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879     145 DFEILPPDIGKLTKLQI--------LSLRDN-DLISLPKEIGELTQLKELHIQGNR-LTVLP-----PELGNLDLTGQKQ 209
Cdd:PLN03210  758 KSEKLWERVQPLTPLMTmlspsltrLFLSDIpSLVELPSSIQNLHKLEHLEIENCInLETLPtginlESLESLDLSGCSR 837


                  .
gi 548879     210 V 210
Cdd:PLN03210  838 L 838
LRR_8 pfam13855
Leucine rich repeat;
109-169 1.02e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 548879     109 RLLEVLELTYNNLneHSL-PGNFFYLTTLRALYLSDNDFEILPPD-IGKLTKLQILSLRDNDL 169
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 32-103 1.09e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 1.09e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548879    32 DVNGLFSLAH-ITQLVLSHNKLTTVPPnVAELKNLEVLNFFNNQI---EELPTQISSLQKLKHLNLGMNRLNTLPR 103
Cdd:cd21340 111 DPRSLAALSNsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQIsdlEELLDLLSSWPSLRELDLTGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-210 1.65e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 1.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879    32 DVNGLFSLAHITQLVLSHNKLTTVPPNvAELKNLEVLNFFNNQIEELptqisSLQKLKHLNLGMNRLNTLPRGFGSSRLL 111
Cdd:COG4886 242 DLPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLI 315

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879   112 EVLELTYNNLNEHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 191
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395

                       170
                ....*....|....*....
gi 548879   192 LTVLPPELGNLDLTGQKQV 210
Cdd:COG4886 396 TTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
41-98 1.65e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 1.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 548879      41 HITQLVLSHNKLTTVPPNVAE-LKNLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRL 98
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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