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Conserved domains on  [gi|61216385|sp|Q03406|]
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RecName: Full=DNA replication complex GINS protein SLD5

Protein Classification

COG5086 family protein( domain architecture ID 11473796)

COG5086 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5086 COG5086
Uncharacterized conserved protein [Function unknown];
1-294 1.00e-89

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 227418 [Multi-domain]  Cd Length: 218  Bit Score: 266.06  E-value: 1.00e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385   1 MDINIDDILAELdkeTTAVDStkitqgssstthrdantivgssldlndktqiyvSPQQDFSDLMKSWKNERCSPELLPYP 80
Cdd:COG5086   1 MDINIDDILAEL---TTAVDS---------------------------------MSFPDLNDLILAWQNERSTPRLLPYA 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385  81 HQLMKRLLNRISMQSQLIEnISMGfldmqnASNANPpmpNESKLpllcMETELERLKFVIRSYIRCRLSKIDKFSLYLRQ 160
Cdd:COG5086  45 LHLIDRFLDRISEQTEHVK-IALG------KSIAKN---NESIL----METELERVKFVVRSYIRTRLKKIDKNLYYDLS 110

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385 161 lneDENSLIsltdLLSKDEIKYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPpdgkw 240
Cdd:COG5086 111 ---DENSLI----LLSGGELAYYEKHSLIYIDLLKDSDLYVTPQKFHKVHDFVGFYCMTDEPDWNKFVFGAVNED----- 178

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 61216385 241 nedplLQENefgkpcYTVTIpdlKEEVELTIGSIYVMRYEVIRDLLRDDKVALI 294
Cdd:COG5086 179 -----LQEN------DTVGE---KELLELFKGDFFVARYDVIMDFLRRNEVILI 218
 
Name Accession Description Interval E-value
COG5086 COG5086
Uncharacterized conserved protein [Function unknown];
1-294 1.00e-89

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227418 [Multi-domain]  Cd Length: 218  Bit Score: 266.06  E-value: 1.00e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385   1 MDINIDDILAELdkeTTAVDStkitqgssstthrdantivgssldlndktqiyvSPQQDFSDLMKSWKNERCSPELLPYP 80
Cdd:COG5086   1 MDINIDDILAEL---TTAVDS---------------------------------MSFPDLNDLILAWQNERSTPRLLPYA 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385  81 HQLMKRLLNRISMQSQLIEnISMGfldmqnASNANPpmpNESKLpllcMETELERLKFVIRSYIRCRLSKIDKFSLYLRQ 160
Cdd:COG5086  45 LHLIDRFLDRISEQTEHVK-IALG------KSIAKN---NESIL----METELERVKFVVRSYIRTRLKKIDKNLYYDLS 110

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385 161 lneDENSLIsltdLLSKDEIKYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPpdgkw 240
Cdd:COG5086 111 ---DENSLI----LLSGGELAYYEKHSLIYIDLLKDSDLYVTPQKFHKVHDFVGFYCMTDEPDWNKFVFGAVNED----- 178

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 61216385 241 nedplLQENefgkpcYTVTIpdlKEEVELTIGSIYVMRYEVIRDLLRDDKVALI 294
Cdd:COG5086 179 -----LQEN------DTVGE---KELLELFKGDFFVARYDVIMDFLRRNEVILI 218
GINS_A_Sld5 cd11711
Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric ...
 59-199 1.24e-29

Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3.


Pssm-ID: 212549  Cd Length: 119  Bit Score: 108.85  E-value: 1.24e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385  59 DFSDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDmqnasnanppmpnesKLPLLCMETELERLKF 138
Cdd:cd11711   1 DLELLKRAWVNEKFAPELLPYQEELVERVLEQIEQQEENLEELKASEKD---------------DLRLSLHEMELERIRF 65

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61216385 139 VIRSYIRCRLSKIDKFSLYLRqlnedenSLISLTDLLSKDEIKYHDTHSLIWLKLVNDSIL 199
Cdd:cd11711  66 LLRSYLRTRLQKIEKYALHIL-------SEEELPSRLSPEELEFAKRYAELLENHLKSSVL 119
SLD5_C pfam16922
DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication ...
 222-294 2.22e-15

DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks.


Pssm-ID: 465315  Cd Length: 57  Bit Score: 69.10  E-value: 2.22e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 61216385   222 PDWNKFVFIHVNgppdgkwnedpllqenefgKPCYTVTIPDLKEE---VELTIGSIYVMRYEVIRDLLRDDKVALI 294
Cdd:pfam16922   1 PDLDTFVFCRVL-------------------KDVGGVTVEGEGEDgdvVELEKGDVYVLRYSSVKPLVESGKVELI 57
 
Name Accession Description Interval E-value
COG5086 COG5086
Uncharacterized conserved protein [Function unknown];
1-294 1.00e-89

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227418 [Multi-domain]  Cd Length: 218  Bit Score: 266.06  E-value: 1.00e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385   1 MDINIDDILAELdkeTTAVDStkitqgssstthrdantivgssldlndktqiyvSPQQDFSDLMKSWKNERCSPELLPYP 80
Cdd:COG5086   1 MDINIDDILAEL---TTAVDS---------------------------------MSFPDLNDLILAWQNERSTPRLLPYA 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385  81 HQLMKRLLNRISMQSQLIEnISMGfldmqnASNANPpmpNESKLpllcMETELERLKFVIRSYIRCRLSKIDKFSLYLRQ 160
Cdd:COG5086  45 LHLIDRFLDRISEQTEHVK-IALG------KSIAKN---NESIL----METELERVKFVVRSYIRTRLKKIDKNLYYDLS 110

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385 161 lneDENSLIsltdLLSKDEIKYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPpdgkw 240
Cdd:COG5086 111 ---DENSLI----LLSGGELAYYEKHSLIYIDLLKDSDLYVTPQKFHKVHDFVGFYCMTDEPDWNKFVFGAVNED----- 178

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 61216385 241 nedplLQENefgkpcYTVTIpdlKEEVELTIGSIYVMRYEVIRDLLRDDKVALI 294
Cdd:COG5086 179 -----LQEN------DTVGE---KELLELFKGDFFVARYDVIMDFLRRNEVILI 218
GINS_A_Sld5 cd11711
Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric ...
 59-199 1.24e-29

Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3.


Pssm-ID: 212549  Cd Length: 119  Bit Score: 108.85  E-value: 1.24e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385  59 DFSDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDmqnasnanppmpnesKLPLLCMETELERLKF 138
Cdd:cd11711   1 DLELLKRAWVNEKFAPELLPYQEELVERVLEQIEQQEENLEELKASEKD---------------DLRLSLHEMELERIRF 65

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61216385 139 VIRSYIRCRLSKIDKFSLYLRqlnedenSLISLTDLLSKDEIKYHDTHSLIWLKLVNDSIL 199
Cdd:cd11711  66 LLRSYLRTRLQKIEKYALHIL-------SEEELPSRLSPEELEFAKRYAELLENHLKSSVL 119
SLD5_C pfam16922
DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication ...
 222-294 2.22e-15

DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks.


Pssm-ID: 465315  Cd Length: 57  Bit Score: 69.10  E-value: 2.22e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 61216385   222 PDWNKFVFIHVNgppdgkwnedpllqenefgKPCYTVTIPDLKEE---VELTIGSIYVMRYEVIRDLLRDDKVALI 294
Cdd:pfam16922   1 PDLDTFVFCRVL-------------------KDVGGVTVEGEGEDgdvVELEKGDVYVLRYSSVKPLVESGKVELI 57
GINS_B_Sld5 cd21692
beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named ...
 222-294 5.88e-12

beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, within which Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. In Drosophila, Sld5 is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. Each subunit of the complex consists of two domains called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Sld5.


Pssm-ID: 412028  Cd Length: 55  Bit Score: 59.48  E-value: 5.88e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61216385 222 PDWNKFVFIHVNGPPDGKwnedpllqenefgkpcytVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI 294
Cdd:cd21692   1 PNLDSFVFCRVLEDVGDV------------------LVDPDGDEEVDLEKGDIHLIRYRSIKDLVESGDVELI 55
Sld5 pfam05916
GINS complex protein; The eukaryotic GINS complex is essential for the initiation and ...
 74-180 6.14e-09

GINS complex protein; The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase.


Pssm-ID: 399129  Cd Length: 105  Bit Score: 52.88  E-value: 6.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61216385    74 PELLPYphqLMKRLLNRISMQSQLIENISMGFLDMQNASNANPP--MPNESKLPLLCMETELER---LKFVIRSYIRCRL 148
Cdd:pfam05916   1 PELPLW---LAELLKRRGLVEIEPPEWLSIEELEAILADETKNDlsLLPPYFYELAVLLLELERddeLKRLLRDYLRIRL 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 61216385   149 SKIDKFSLYLRQLNEDENSLisltDLLSKDEI 180
Cdd:pfam05916  78 AKIRKLAWHLNGSLSPSDLL----DNLSEEEL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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