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Conserved domains on  [gi|464356|sp|Q05028|]
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RecName: Full=Platelet-derived growth factor subunit B; Short=PDGF subunit B; AltName: Full=PDGF-2; AltName: Full=Platelet-derived growth factor B chain; AltName: Full=Platelet-derived growth factor beta polypeptide; Flags: Precursor

Protein Classification

PDGF_N and PDGF domain-containing protein( domain architecture ID 10520088)

PDGF_N and PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
89-172 2.45e-30

PDGF/VEGF domain;


:

Pssm-ID: 425620  Cd Length: 82  Bit Score: 107.37  E-value: 2.45e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356      89 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPVFKKATVTLEDHL 168
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 464356     169 ACKC 172
Cdd:pfam00341  79 QCEC 82
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 13-85 3.31e-21

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


:

Pssm-ID: 461394  Cd Length: 78  Bit Score: 83.64  E-value: 3.31e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 464356      13 EGDPIPEELYEMLSDHSIRSFDDLQRLLHRDSVDEDGAELDLNMTRAHSGVESESSSRGRRSLGS-----LAAAEPAV 85
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHRAHSDHSSSSVDLKRRQLHSrrkrsIEEAVPAV 78
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
89-172 2.45e-30

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 107.37  E-value: 2.45e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356      89 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPVFKKATVTLEDHL 168
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 464356     169 ACKC 172
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 87-174 4.10e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 96.72  E-value: 4.10e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356       87 AECKTRTEVFQISRNLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMrpVQVRKIEIVRKKPVfKKATVTLED 166
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 464356      167 HLACKCET 174
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 87-174 3.17e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 91.66  E-value: 3.17e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356    87 AECKTRTEVFQISRNLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRkKPVFKKATVTLED 166
Cdd:cd00135   1 SSCKPRETLVEISEELPDETN--TIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                ....*...
gi 464356   167 HLACKCET 174
Cdd:cd00135  78 HTECECRP 85
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 13-85 3.31e-21

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 83.64  E-value: 3.31e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 464356      13 EGDPIPEELYEMLSDHSIRSFDDLQRLLHRDSVDEDGAELDLNMTRAHSGVESESSSRGRRSLGS-----LAAAEPAV 85
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHRAHSDHSSSSVDLKRRQLHSrrkrsIEEAVPAV 78
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 89-192 6.89e-11

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 58.48  E-value: 6.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356     89 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPVFKK-ATVTLEDH 167
Cdd:PHA02661  48 CQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNfQTISVEEH 125

                         90       100
                 ....*....|....*....|....*
gi 464356    168 LACKCETVVTPRPVTrspgTSREHR 192
Cdd:PHA02661 126 TKCKCEFKTTPPPTT----TTREPR 146
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
89-172 2.45e-30

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 107.37  E-value: 2.45e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356      89 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPVFKKATVTLEDHL 168
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 464356     169 ACKC 172
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 87-174 4.10e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 96.72  E-value: 4.10e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356       87 AECKTRTEVFQISRNLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMrpVQVRKIEIVRKKPVfKKATVTLED 166
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 464356      167 HLACKCET 174
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 87-174 3.17e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 91.66  E-value: 3.17e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356    87 AECKTRTEVFQISRNLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRkKPVFKKATVTLED 166
Cdd:cd00135   1 SSCKPRETLVEISEELPDETN--TIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                ....*...
gi 464356   167 HLACKCET 174
Cdd:cd00135  78 HTECECRP 85
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 13-85 3.31e-21

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 83.64  E-value: 3.31e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 464356      13 EGDPIPEELYEMLSDHSIRSFDDLQRLLHRDSVDEDGAELDLNMTRAHSGVESESSSRGRRSLGS-----LAAAEPAV 85
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHRAHSDHSSSSVDLKRRQLHSrrkrsIEEAVPAV 78
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 89-192 6.89e-11

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 58.48  E-value: 6.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464356     89 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPVFKK-ATVTLEDH 167
Cdd:PHA02661  48 CQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNfQTISVEEH 125

                         90       100
                 ....*....|....*....|....*
gi 464356    168 LACKCETVVTPRPVTrspgTSREHR 192
Cdd:PHA02661 126 TKCKCEFKTTPPPTT----TTREPR 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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