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Conserved domains on  [gi|2498838|sp|Q09150|]
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RecName: Full=Meiotic recombination protein rec14

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-297 9.63e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 205.26  E-value: 9.63e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   15 HQADIYSLNVVAGN--LWSASGDSKIKKWsigDAEHSLVEEIDTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNE 92
Cdd:cd00200   8 HTGGVTCVAFSPDGklLATGSGDGTIKVW---DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   93 -FRDLgnnAQHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFL 171
Cdd:cd00200  85 cVRTL---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  172 ISTETGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEG 251
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 2498838  252 KIKIWDIDTMECISTQSETDGAIWAVAWYKNG--FIVAGADKSIRWYR 297
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkrLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-297 9.63e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 205.26  E-value: 9.63e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   15 HQADIYSLNVVAGN--LWSASGDSKIKKWsigDAEHSLVEEIDTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNE 92
Cdd:cd00200   8 HTGGVTCVAFSPDGklLATGSGDGTIKVW---DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   93 -FRDLgnnAQHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFL 171
Cdd:cd00200  85 cVRTL---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  172 ISTETGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEG 251
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 2498838  252 KIKIWDIDTMECISTQSETDGAIWAVAWYKNG--FIVAGADKSIRWYR 297
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
29-294 3.68e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.66  E-value: 3.68e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   29 LWSASGDSKIKKWSIGDAEhsLVEEIdTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNEFrdLGNNAQHPSECWS 108
Cdd:COG2319 135 LASGSADGTVRLWDLATGK--LLRTL-TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRS 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  109 SCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFLISTETGRLFHVLSGHTS 188
Cdd:COG2319 210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  189 PVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDIDTMECISTQS 268
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                       250       260
                ....*....|....*....|....*...
gi 2498838  269 ETDGAIWAVAWYKNG--FIVAGADKSIR 294
Cdd:COG2319 370 GHTGAVTSVAFSPDGrtLASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 176-215 8.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 8.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2498838     176 TGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
219-257 1.19e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2498838    219 GDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWD 257
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 183-292 1.71e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   183 LSGHTSPVRSVAFSPGST-LLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDIDTM 261
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 2498838   262 ECISTQSETDGA-----IWAVAwyKNGFIVAGADKS 292
Cdd:PTZ00421 201 TIVSSVEAHASAksqrcLWAKR--KDLIITLGCSKS 234
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-297 9.63e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 205.26  E-value: 9.63e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   15 HQADIYSLNVVAGN--LWSASGDSKIKKWsigDAEHSLVEEIDTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNE 92
Cdd:cd00200   8 HTGGVTCVAFSPDGklLATGSGDGTIKVW---DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   93 -FRDLgnnAQHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFL 171
Cdd:cd00200  85 cVRTL---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  172 ISTETGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEG 251
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 2498838  252 KIKIWDIDTMECISTQSETDGAIWAVAWYKNG--FIVAGADKSIRWYR 297
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
29-294 3.68e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.66  E-value: 3.68e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   29 LWSASGDSKIKKWSIGDAEhsLVEEIdTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNEFrdLGNNAQHPSECWS 108
Cdd:COG2319 135 LASGSADGTVRLWDLATGK--LLRTL-TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRS 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  109 SCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFLISTETGRLFHVLSGHTS 188
Cdd:COG2319 210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  189 PVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDIDTMECISTQS 268
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                       250       260
                ....*....|....*....|....*...
gi 2498838  269 ETDGAIWAVAWYKNG--FIVAGADKSIR 294
Cdd:COG2319 370 GHTGAVTSVAFSPDGrtLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
15-299 1.63e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 1.63e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   15 HQADIYSLNVVAGNLW--SASGDSKIKKWsigDAEHSLVEEIDTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNE 92
Cdd:COG2319  77 HTAAVLSVAFSPDGRLlaSASADGTVRLW---DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   93 F-RDLgnnAQHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFL 171
Cdd:COG2319 154 LlRTL---TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  172 ISTETGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEG 251
Cdd:COG2319 231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 2498838  252 KIKIWDIDTMECISTQSETDGAIWAVAWYKNG--FIVAGADKSIRWYRAA 299
Cdd:COG2319 311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGktLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
13-260 5.24e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.78  E-value: 5.24e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   13 NAHQADIYSLNVVAGN--LWSASGDSKIKKWSI--GDAEHSLveeidTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNP 88
Cdd:COG2319 159 TGHSGAVTSVAFSPDGklLASGSDDGTVRLWDLatGKLLRTL-----TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   89 ETNEFRDLGNNaqHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQ 168
Cdd:COG2319 234 ATGKLLRTLTG--HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  169 LFLISTETGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSAD 248
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391

                       250
                ....*....|..
gi 2498838  249 VEGKIKIWDIDT 260
Cdd:COG2319 392 ADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
100-302 3.18e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 3.18e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  100 AQHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFLISTETGRL 179
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  180 FHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDID 259
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 2498838  260 TMECISTQSETDGAIWAVAWYKNGFIVA--GADKSIRWYRAAATE 302
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFSPDGKLLAsgSADGTVRLWDLATGK 237
WD40 COG2319
WD40 repeat [General function prediction only];
112-302 7.43e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 7.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  112 SPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFLISTETGRLFHVLSGHTSPVR 191
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  192 SVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDIDTMECISTQSETD 271
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                       170       180       190
                ....*....|....*....|....*....|...
gi 2498838  272 GAIWAVAWYKNG--FIVAGADKSIRWYRAAATE 302
Cdd:COG2319 163 GAVTSVAFSPDGklLASGSDDGTVRLWDLATGK 195
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 179-296 3.38e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 3.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  179 LFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDI 258
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 2498838  259 DTMECISTQSETDGAIWAVAWYKNGFIVAGA--DKSIRWY 296
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsrDKTIKVW 120
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 82-208 5.28e-10

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 56.99  E-value: 5.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   82 DVYVWNPETNEFRDLGNnaqHPSECWSSCISPDGQTIAFTSV-DGRIAVWD-NPSDCKISELDTKGKFGLCIDYSPNGRF 159
Cdd:COG0823  12 DIYVVDLDGGEPRRLTN---SPGIDTSPAWSPDGRRIAFTSDrGGGPQIYVvDADGGEPRRLTFGGGYNASPSWSPDGKR 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 2498838  160 IVSGHQTG---QLFLISTETGRLFHVLSGHTSPvrsvAFSPGSTLLAAAGDS 208
Cdd:COG0823  89 LAFVSRSDgrfDIYVLDLDGGAPRRLTDGPGSP----SWSPDGRRIVFSSDR 136
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 176-215 8.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 8.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2498838     176 TGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 218-257 2.54e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.54e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2498838     218 SGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWD 257
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
151-266 5.75e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.61  E-value: 5.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  151 IDYSPNGRFI-VSGHQTGQLFLISTETGRLFHVLSGHTSPvRSVAFSP-GSTLLAAAGDSKMITIYDVLSGDQVGQLR-G 227
Cdd:COG3391  73 ADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPdGGRLYVADSGNGRVSVIDTATGKVVATIPvG 151

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 2498838  228 HAAWifAVAFNPVGDLLLSADVEGK-----IKIWDIDTMECIST 266
Cdd:COG3391 152 AGPH--GIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVAT 193
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 112-198 7.30e-06

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 47.34  E-value: 7.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   112 SPDGQTIAFTSVDGRIAVWDnPSDCKISELDTKGKFGLCIDY--SPNGRFIV----SGHQTGQLFLISTETGRLfHVLSG 185
Cdd:COG4946  397 SPDGKKIAFTDNRGRLWVVD-LASGKVRKVDTDGYGDGISDLawSPDSKWLAyskpGPNQLSQIFLYDVETGKT-VQLTD 474

                         90
                 ....*....|...
gi 2498838   186 HTSPVRSVAFSPG 198
Cdd:COG4946  475 GRYDDGSPAFSPD 487
WD40 pfam00400
WD domain, G-beta repeat;
219-257 1.19e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2498838    219 GDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWD 257
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
177-215 1.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2498838    177 GRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
18-219 1.41e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 1.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   18 DIYSLNVVAGNLWSASGDSKIKKWSIGDAEHSLVEEIDTPHKLGVHHLATSLDEN-VVVSCGFGQDVYVWNPETNEFRDL 96
Cdd:COG3391  26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDLATGKVVAT 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   97 GNNAQHPsecWSSCISPDGQTIAFTSV-DGRIAVWDNPSDCKISELDTkGKFGLCIDYSPNGRFI-VSGHQTGQ----LF 170
Cdd:COG3391 106 IPVGGGP---RGLAVDPDGGRLYVADSgNGRVSVIDTATGKVVATIPV-GAGPHGIAVDPDGKRLyVANSGSNTvsviVS 181

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 2498838  171 LISTETGRLFHVLSGHTSPVrSVAFSPGSTLL--------AAAGDSKMITIYDVLSG 219
Cdd:COG3391 182 VIDTATGKVVATIPVGGGPV-GVAVSPDGRRLyvanrgsnTSNGGSNTVSVIDLATL 237
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 112-240 5.75e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 44.64  E-value: 5.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   112 SPDGQTIAFTS-VDGRIAVWDNPSD-----CKISELDTKGKFGLciDYSPNGRFIVSGHQTGQLFLISTETGRLFHVL-S 184
Cdd:COG4946  351 SPDGKSIAYFSdASGEYELYIAPADgsgepKQLTLGDLGRVFNP--VWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDtD 428

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2498838   185 GHTSPVRSVAFSPGSTLLAAA--GDSKM--ITIYDVlSGDQVGQL-RGhaawiFAVAFNPV 240
Cdd:COG4946  429 GYGDGISDLAWSPDSKWLAYSkpGPNQLsqIFLYDV-ETGKTVQLtDG-----RYDDGSPA 483
PTZ00421 PTZ00421
coronin; Provisional
 183-292 1.71e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   183 LSGHTSPVRSVAFSPGST-LLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDIDTM 261
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 2498838   262 ECISTQSETDGA-----IWAVAwyKNGFIVAGADKS 292
Cdd:PTZ00421 201 TIVSSVEAHASAksqrcLWAKR--KDLIITLGCSKS 234
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 24-259 1.79e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 39.19  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   24 VVAGNLW----SASGDSKIKKWSIGDAEHSLveeiDTPHKLGVHHlatslDENVVVSCGFGQDVYVWNPETNEFRDLGNN 99
Cdd:cd14956  29 ADARNGRiqvfDKDGTFLRRFGTTGDGPGQF----GRPRGLAVDK-----DGWLYVADYWGDRIQVFTLTGELQTIGGSS 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  100 AQHPSECwsscispDGQTIAFTSVDGRIAVWDNPSDcKISELDtkgkfglcidysPNGRFIVSGHQTGQlflistETGRL 179
Cdd:cd14956 100 GSGPGQF-------NAPRGVAVDADGNLYVADFGNQ-RIQKFD------------PDGSFLRQWGGTGI------EPGSF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  180 fhvlsghTSPvRSVAFSPGSTLLAAAGDSKMITIYDvLSGDQVGQLRGHAA------WIFAVAFNPVGDLLLSADVEGKI 253
Cdd:cd14956 154 -------NYP-RGVAVDPDGTLYVADTYNDRIQVFD-NDGAFLRKWGGRGTgpgqfnYPYGIAIDPDGNVFVADFGNNRI 224


                ....*.
gi 2498838  254 KIWDID 259
Cdd:cd14956 225 QKFTAD 230
PTZ00420 PTZ00420
coronin; Provisional
 183-259 1.83e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   183 LSGHTSPVRSVAFSPG-STLLAAAGDSKMITIYDVLSGDQ-VGQ-------LRGHAAWIFAVAFNPVGDLLL-SADVEGK 252
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDEsVKEikdpqciLKGHKKKISIIDWNPMNYYIMcSSGFDSF 149


                 ....*..
gi 2498838   253 IKIWDID 259
Cdd:PTZ00420 150 VNIWDIE 156
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
51-219 2.90e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 38.46  E-value: 2.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   51 VEEIDTPHKL-GVHHLATSLDENVVVSCGFGQDVYVWNPETNEFRDLGNNAqhPSECWSSCISPDGqTIAFT-SVDGRIA 128
Cdd:COG4257   7 ITEYPVPAPGsGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGG--GSGPHGIAVDPDG-NLWFTdNGNNRIG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838  129 VWDnPSDCKISELDTKGK----FGLCIDysPNGRFIVSGHQTGQLFLISTETGR--LFHVLSGHTSPvRSVAFSPGSTLL 202
Cdd:COG4257  84 RID-PKTGEITTFALPGGgsnpHGIAFD--PDGNLWFTDQGGNRIGRLDPATGEvtEFPLPTGGAGP-YGIAVDPDGNLW 159

                       170
                ....*....|....*..
gi 2498838  203 AAAGDSKMITIYDVLSG 219
Cdd:COG4257 160 VTDFGANAIGRIDPDTG 176
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 118-196 3.46e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838    118 IAFTSVDGRIA--------VWDNP---SDCKISeldtkgkfglCIDYSPNGRFIVSGHQTGQLFLISTETGRLFHVLSGH 186
Cdd:pfam12894  10 IALATEDGELLlhrlnwqrVWTLSpdkEDLEVT----------SLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79

                          90
                  ....*....|
gi 2498838    187 TSPVRSVAFS 196
Cdd:pfam12894  80 SDLITCLGWG 89
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 82-130 5.98e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 36.57  E-value: 5.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 2498838   82 DVYVWNPETNEFRDLGNNAQHPSecwsscISPDGQTIAFTSV-DGRIAVW 130
Cdd:COG0823 100 DIYVLDLDGGAPRRLTDGPGSPS------WSPDGRRIVFSSDrGGRPDLY 143
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
13-179 8.34e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 37.58  E-value: 8.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   13 NAHQADIYSLN--VVAGNLwsasGDSKIKKWSIGDAEHSL--VEEIDTPHKLGVHHLATSLDEN-VVVSCGFGQ--DVYV 85
Cdd:COG2706 151 HAHSVVFDPDGrfLYVPDL----GTDRIYVYRLDPATGKLpePPEVSLPPGSGPRHLAFHPNGRfAYVINELDStvSVYA 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498838   86 WNPETNEFRDLGN----NAQHPSECWSS--CISPDGQTiAFTSV--DGRIAVW----DNPSDCKISELDTKGKFGLCIDY 153
Cdd:COG2706 227 YDAATGTLTLIQTvstlPEDFTGENWAAdiHISPDGRF-LYVSNrgHNSIAVFaidaDGGKLTLVGHVPTGGKWPRDFAI 305

                       170       180
                ....*....|....*....|....*....
gi 2498838  154 SPNGRFIVSGHQTG---QLFLISTETGRL 179
Cdd:COG2706 306 DPDGRFLLVANQKSdniTVFRIDADTGKL 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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