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Conserved domains on  [gi|27808654|sp|Q09522|]
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RecName: Full=Probable dimethyladenosine transferase; AltName: Full=Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; AltName: Full=Probable 18S rRNA dimethylase; AltName: Full=Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase

Protein Classification

dimethyladenosine transferase( domain architecture ID 10794378)

dimethyladenosine transferase specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008173|GO:0031167|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 15-306 2.04e-162

dimethyladenosine transferase-like protein; Provisional


:

Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 453.69  E-value: 2.04e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   15 STGNVQSLPFNTDKGQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVMG 94
Cdd:PTZ00338   1 TGGSKSGMVFNKKFGQHILKNPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRFQN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   95 TPLQNKLQVNGGDVMKMEWPFFDVCVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQ 174
Cdd:PTZ00338  81 SPLASKLEVIEGDALKTEFPYFDVCVANVPYQISSPLVFKLLAHRPLFRCAVLMFQKEFALRLLAQPGDELYCRLSVNTQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  175 LLAKVEMLMKVKRTEFRPPPKVDSAVVRIAPKNPPPPVNFVEWEGLLRLCFMRKNKTLMAIFRLSNVIEVIEDNFRKVCS 254
Cdd:PTZ00338 161 LLCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNPPPDVDFEEWDGLLRICFSRKNKTLSAIFKTKSVLQTLEHNYKSWCT 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27808654  255 FKNKPIPKDLN-MKKVIEETLTASGYGESRARKMRVEDFLALLLAFNKADIHF 306
Cdd:PTZ00338 241 MINKKVPVSLEpFKEFIAEILEDSGMFEKRSVKLDIDDFLKLLLAFNKKGIHF 293
 
Name Accession Description Interval E-value
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 15-306 2.04e-162

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 453.69  E-value: 2.04e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   15 STGNVQSLPFNTDKGQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVMG 94
Cdd:PTZ00338   1 TGGSKSGMVFNKKFGQHILKNPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRFQN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   95 TPLQNKLQVNGGDVMKMEWPFFDVCVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQ 174
Cdd:PTZ00338  81 SPLASKLEVIEGDALKTEFPYFDVCVANVPYQISSPLVFKLLAHRPLFRCAVLMFQKEFALRLLAQPGDELYCRLSVNTQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  175 LLAKVEMLMKVKRTEFRPPPKVDSAVVRIAPKNPPPPVNFVEWEGLLRLCFMRKNKTLMAIFRLSNVIEVIEDNFRKVCS 254
Cdd:PTZ00338 161 LLCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNPPPDVDFEEWDGLLRICFSRKNKTLSAIFKTKSVLQTLEHNYKSWCT 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27808654  255 FKNKPIPKDLN-MKKVIEETLTASGYGESRARKMRVEDFLALLLAFNKADIHF 306
Cdd:PTZ00338 241 MINKKVPVSLEpFKEFIAEILEDSGMFEKRSVKLDIDDFLKLLLAFNKKGIHF 293
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 29-302 8.72e-81

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 245.81  E-value: 8.72e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  29 GQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVmgtPLQNKLQVNGGDV 108
Cdd:COG0030  16 GQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETF---AAYPNLTVIEGDA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654 109 MKMEWP-----FFDVCVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQLLAKVEMLM 183
Cdd:COG0030  93 LKVDLPalaagEPLKVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYADVEILF 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654 184 KVKRTEFRPPPKVDSAVVRIAPKNPP--PPVNFVEWEGLLRLCFMRKNKTLmaifrlSNVIeviednfrkvcsfknkpip 261
Cdd:COG0030 173 TVPPEAFYPPPKVDSAVVRLTPRPEPlvPVADEKLFFRVVKAAFSQRRKTL------RNSL------------------- 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 27808654 262 KDLNMKKVIEETLTASGYGES-RARKMRVEDFLALLLAFNKA 302
Cdd:COG0030 228 KSLFSKERLEEALEAAGIDPTaRAEELSVEEFARLANALKKR 269
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 29-299 1.17e-79

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 242.14  E-value: 1.17e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654    29 GQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVmgtPLQNKLQVNGGDV 108
Cdd:TIGR00755   8 GQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLL---SLYNNLEIIEGDA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   109 MKMEWPFFDV----CVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQLLAKVEMLMK 184
Cdd:TIGR00755  85 LKFDLNELAKdltkVVGNLPYNISSPLIFKLLKEKDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYANVEIVFK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   185 VKRTEFRPPPKVDSAVVRIAPKNPPP-PVNFVEWEGLLRLCFMRKNKTLMAIFR--LSNVIEVIEDnfrkvcsfknkpip 261
Cdd:TIGR00755 165 VPPSAFYPPPKVDSAVVRLVPLKRKPsPKDFALFEELLKAAFQQRRKTLRNNLKnlLSELVELLEE-------------- 230

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 27808654   262 KDLNMKKvieetltasgygesRARKMRVEDFLALLLAF 299
Cdd:TIGR00755 231 LGIDPDK--------------RVEQLSPEDFLRLANLL 254
rADc smart00650
Ribosomal RNA adenine dimethylases;
38-207 1.45e-75

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 228.55  E-value: 1.45e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654     38 VVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVmgtPLQNKLQVNGGDVMKMEWPF-- 115
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKF---AAADNLTVIHGDALKFDLPKlq 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654    116 FDVCVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQLLAKVEMLMKVKRTEFRPPPK 195
Cdd:smart00650  78 PYKVVGNLPYNISTPILFKLLEEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPK 157

                          170
                   ....*....|..
gi 27808654    196 VDSAVVRIAPKN 207
Cdd:smart00650 158 VDSAVVRLERRP 169
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
24-232 3.58e-66

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 207.99  E-value: 3.58e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654    24 FNTDKGQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVMGTPlqnKLQV 103
Cdd:pfam00398   4 FRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDE---NLTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   104 NGGDVMKMEWP-------FFDVCVANLPYQISSPFVQKLL-LHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQL 175
Cdd:pfam00398  81 IHQDFLKFEFPslvthihQEFLVVGNLPYNISTPIVKQLLfESRFGIVDMLLMLQKEFARRLLARPGSKLYSRLSVLRQA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 27808654   176 LAKVEMLMKVKRTEFRPPPKVDSAVVRIAPKNPPP-PVNFVE-WEGLLRLCFMRKNKTL 232
Cdd:pfam00398 161 FTDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDPhPVKDLDvYDSVVRKLFNRKRKTL 219
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 53-150 2.42e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 53.97  E-value: 2.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  53 TVLEVGPGTGNLTVKMLE-VAKTVIACEIDPRMIAEVKKRVMGtPLQNKLQVNGGDVmkMEWPF-----FDVCVANLPYQ 126
Cdd:cd02440   1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAA-LLADNVEVLKGDA--EELPPeadesFDVIISDPPLH 77

                        90       100
                ....*....|....*....|....*.
gi 27808654 127 ISSPFVQKLL--LHRPLPRYAVLMFQ 150
Cdd:cd02440  78 HLVEDLARFLeeARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 15-306 2.04e-162

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 453.69  E-value: 2.04e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   15 STGNVQSLPFNTDKGQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVMG 94
Cdd:PTZ00338   1 TGGSKSGMVFNKKFGQHILKNPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRFQN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   95 TPLQNKLQVNGGDVMKMEWPFFDVCVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQ 174
Cdd:PTZ00338  81 SPLASKLEVIEGDALKTEFPYFDVCVANVPYQISSPLVFKLLAHRPLFRCAVLMFQKEFALRLLAQPGDELYCRLSVNTQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  175 LLAKVEMLMKVKRTEFRPPPKVDSAVVRIAPKNPPPPVNFVEWEGLLRLCFMRKNKTLMAIFRLSNVIEVIEDNFRKVCS 254
Cdd:PTZ00338 161 LLCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNPPPDVDFEEWDGLLRICFSRKNKTLSAIFKTKSVLQTLEHNYKSWCT 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27808654  255 FKNKPIPKDLN-MKKVIEETLTASGYGESRARKMRVEDFLALLLAFNKADIHF 306
Cdd:PTZ00338 241 MINKKVPVSLEpFKEFIAEILEDSGMFEKRSVKLDIDDFLKLLLAFNKKGIHF 293
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 29-302 8.72e-81

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 245.81  E-value: 8.72e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  29 GQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVmgtPLQNKLQVNGGDV 108
Cdd:COG0030  16 GQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETF---AAYPNLTVIEGDA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654 109 MKMEWP-----FFDVCVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQLLAKVEMLM 183
Cdd:COG0030  93 LKVDLPalaagEPLKVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYADVEILF 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654 184 KVKRTEFRPPPKVDSAVVRIAPKNPP--PPVNFVEWEGLLRLCFMRKNKTLmaifrlSNVIeviednfrkvcsfknkpip 261
Cdd:COG0030 173 TVPPEAFYPPPKVDSAVVRLTPRPEPlvPVADEKLFFRVVKAAFSQRRKTL------RNSL------------------- 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 27808654 262 KDLNMKKVIEETLTASGYGES-RARKMRVEDFLALLLAFNKA 302
Cdd:COG0030 228 KSLFSKERLEEALEAAGIDPTaRAEELSVEEFARLANALKKR 269
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 29-299 1.17e-79

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 242.14  E-value: 1.17e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654    29 GQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVmgtPLQNKLQVNGGDV 108
Cdd:TIGR00755   8 GQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLL---SLYNNLEIIEGDA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   109 MKMEWPFFDV----CVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQLLAKVEMLMK 184
Cdd:TIGR00755  85 LKFDLNELAKdltkVVGNLPYNISSPLIFKLLKEKDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYANVEIVFK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   185 VKRTEFRPPPKVDSAVVRIAPKNPPP-PVNFVEWEGLLRLCFMRKNKTLMAIFR--LSNVIEVIEDnfrkvcsfknkpip 261
Cdd:TIGR00755 165 VPPSAFYPPPKVDSAVVRLVPLKRKPsPKDFALFEELLKAAFQQRRKTLRNNLKnlLSELVELLEE-------------- 230

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 27808654   262 KDLNMKKvieetltasgygesRARKMRVEDFLALLLAF 299
Cdd:TIGR00755 231 LGIDPDK--------------RVEQLSPEDFLRLANLL 254
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
25-296 3.23e-79

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 241.34  E-value: 3.23e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   25 NTDKGQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRvmgTPLQNKLQVN 104
Cdd:PRK14896   4 NKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDD---EIAAGNVEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  105 GGDVMKMEWPFFDVCVANLPYQISSPFVQKLLLHRPLPryAVLMFQKEFADRLVARPGDKDYSRLSVNVQLLAKVEMLMK 184
Cdd:PRK14896  81 EGDALKVDLPEFNKVVSNLPYQISSPITFKLLKHGFEP--AVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYADVEIVEK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  185 VKRTEFRPPPKVDSAVVRIAPKNPPPPVN--FVEwEGLLRLCFMRKNKTLMAIFRLSNVIEVIEDNFRKVcsfknKPIPK 262
Cdd:PRK14896 159 VPPGAFSPKPKVDSAVVRLTPREPKYEVYdeDFF-DDFVKALFQHRRKTLRNALKNSAHISGKEDIKAVV-----EALPE 232

                        250       260       270
                 ....*....|....*....|....*....|....
gi 27808654  263 DLNmkkvieetltasgygESRARKMRVEDFLALL 296
Cdd:PRK14896 233 ELL---------------NKRVFQLSPEEIAELA 251
rADc smart00650
Ribosomal RNA adenine dimethylases;
38-207 1.45e-75

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 228.55  E-value: 1.45e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654     38 VVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVmgtPLQNKLQVNGGDVMKMEWPF-- 115
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKF---AAADNLTVIHGDALKFDLPKlq 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654    116 FDVCVANLPYQISSPFVQKLLLHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQLLAKVEMLMKVKRTEFRPPPK 195
Cdd:smart00650  78 PYKVVGNLPYNISTPILFKLLEEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPK 157

                          170
                   ....*....|..
gi 27808654    196 VDSAVVRIAPKN 207
Cdd:smart00650 158 VDSAVVRLERRP 169
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
24-232 3.58e-66

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 207.99  E-value: 3.58e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654    24 FNTDKGQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVMGTPlqnKLQV 103
Cdd:pfam00398   4 FRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDE---NLTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   104 NGGDVMKMEWP-------FFDVCVANLPYQISSPFVQKLL-LHRPLPRYAVLMFQKEFADRLVARPGDKDYSRLSVNVQL 175
Cdd:pfam00398  81 IHQDFLKFEFPslvthihQEFLVVGNLPYNISTPIVKQLLfESRFGIVDMLLMLQKEFARRLLARPGSKLYSRLSVLRQA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 27808654   176 LAKVEMLMKVKRTEFRPPPKVDSAVVRIAPKNPPP-PVNFVE-WEGLLRLCFMRKNKTL 232
Cdd:pfam00398 161 FTDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDPhPVKDLDvYDSVVRKLFNRKRKTL 219
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 53-150 2.42e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 53.97  E-value: 2.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  53 TVLEVGPGTGNLTVKMLE-VAKTVIACEIDPRMIAEVKKRVMGtPLQNKLQVNGGDVmkMEWPF-----FDVCVANLPYQ 126
Cdd:cd02440   1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAA-LLADNVEVLKGDA--EELPPeadesFDVIISDPPLH 77

                        90       100
                ....*....|....*....|....*.
gi 27808654 127 ISSPFVQKLL--LHRPLPRYAVLMFQ 150
Cdd:cd02440  78 HLVEDLARFLeeARRLLKPGGVLVLT 103
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 41-123 2.76e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 54.61  E-value: 2.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  41 AIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVMGTPLQNKLQVngGDVMKMEWP--FFDV 118
Cdd:COG2226  13 ALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVV--GDAEDLPFPdgSFDL 90


                ....*
gi 27808654 119 CVANL 123
Cdd:COG2226  91 VISSF 95
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 54-162 5.90e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 52.57  E-value: 5.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654    54 VLEVGPGTGNLTVKMLE-VAKTVIACEIDPRMIAEVKKRVMGTPLQNKLQVngGDVMKMEWP--FFDVCVANLpyqissp 130
Cdd:pfam13649   1 VLDLGCGTGRLTLALARrGGARVTGVDLSPEMLERARERAAEAGLNVEFVQ--GDAEDLPFPdgSFDLVVSSG------- 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 27808654   131 fvqkLLLHRPLPRYAVLMfqKEFADRLvaRPG 162
Cdd:pfam13649  72 ----VLHHLPDPDLEAAL--REIARVL--KPG 95
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 55-123 1.24e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 46.12  E-value: 1.24e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27808654    55 LEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRvmGTPLQNKLQVngGDVMKMewPF----FDVCVANL 123
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREK--APREGLTFVV--GDAEDL--PFpdnsFDLVLSSE 67
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 27-91 1.47e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.99  E-value: 1.47e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27808654  27 DKGQHILKNPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLE-VAKTVIACEIDPRMIAEVKKR 91
Cdd:COG0500   3 DSYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAArFGGRVIGIDLSPEAIALARAR 68
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 29-91 1.56e-05

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 44.69  E-value: 1.56e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27808654  29 GQHILKnPGVVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKR 91
Cdd:COG2518  46 GQTISQ-PYIVARMLEALDLKPGDRVLEIGTGSGYQAAVLARLAGRVYSVERDPELAERARER 107
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 45-122 1.70e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 43.47  E-value: 1.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  45 KSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVmgtpLQNKLQVNGGDVMKMEWP--FFDVCVAN 122
Cdd:COG2227  19 ARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERA----AELNVDFVQGDLEDLPLEdgSFDLVICS 94
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 48-125 2.39e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 44.75  E-value: 2.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  48 LKATDTVLEVGPGTGNLTvkmLEVAK-----TVIACEIDPRMIAEVKKRVMGTPLQNKLQVNGGDVMKMEWPF----FDV 118
Cdd:COG4123  35 VKKGGRVLDLGTGTGVIA---LMLAQrspgaRITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFAAELppgsFDL 111


                ....*..
gi 27808654 119 CVANLPY 125
Cdd:COG4123 112 VVSNPPY 118
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
33-91 8.09e-05

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 42.89  E-value: 8.09e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27808654  33 LKNPGVV-----------NAIVEKSALKATDTVLEVGPGTGNLTVKMLEV---AKTVIACEIDPRMIAEVKKR 91
Cdd:COG3963  17 LRNPRTVgaiapssralaRAMASEVDWSGAGPVVELGPGTGVFTRAILARgvpDARLLAVEINPEFAEHLRRR 89
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 55-122 1.18e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 40.43  E-value: 1.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27808654    55 LEVGPGTGNLTVKMLEVAK--TVIACEIDPRMIAEVKKRVMGTPLQNKLQVNG--GDVMKMEWPFFDVCVAN 122
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPglEYTGLDISPAALEAARERLAALGLLNAVRVELfqLDLGELDPGSFDVVVAS 72
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
45-121 2.62e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 41.56  E-value: 2.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  45 KSALKAT----DTVLEVGPGTGNLTvkMLEV---AKTVIACEIDPRMIAEVKKRVMGTPLQNKLQVNGGDVMKMEWPF-F 116
Cdd:COG4076  26 KAAIERVvkpgDVVLDIGTGSGLLS--MLAAragAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEkA 103


                ....*
gi 27808654 117 DVCVA 121
Cdd:COG4076 104 DVIIS 108
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
38-125 3.74e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.75  E-value: 3.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  38 VVNAIVEKSALKATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRvmgtPLQNKLQVngGDVMKMEWPF-- 115
Cdd:COG4976  34 LAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK----GVYDRLLV--ADLADLAEPDgr 107

                        90
                ....*....|..
gi 27808654 116 FDVCVAN--LPY 125
Cdd:COG4976 108 FDLIVAAdvLTY 119
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
53-122 3.80e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 39.04  E-value: 3.80e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27808654  53 TVLEVGPGTGNLTVKMLEVAK--TVIACEIDPRMIAEVKKRVMGTPLQNklqvngGDVmkMEWPF---FDVCVAN 122
Cdd:COG4106   4 RVLDLGCGTGRLTALLAERFPgaRVTGVDLSPEMLARARARLPNVRFVV------ADL--RDLDPpepFDLVVSN 70
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 41-157 2.12e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 38.39  E-value: 2.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  41 AIVEKSALKATDTVLEvgP--GTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRvMGTPLQNKLQVNGGDVMKMEWPF--F 116
Cdd:COG1041  17 ALVNLAGAKEGDTVLD--PfcGTGTILIEAGLLGRRVIGSDIDPKMVEGAREN-LEHYGYEDADVIRGDARDLPLADesV 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 27808654 117 DVCVANLPY--QISSP------FVQKLL--LHRPLPR--YAVLMFQKEFADRL 157
Cdd:COG1041  94 DAIVTDPPYgrSSKISgeelleLYEKALeeAARVLKPggRVVIVTPRDIDELL 146
PRK08317 PRK08317
hypothetical protein; Provisional
 47-168 2.71e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 38.38  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   47 ALKATDTVLEVGPGTGNLTVKML-EVAKT--VIACEIDPRMIAEVKKRVM--GTPLQNKLqvngGDVMKMEWP--FFDVC 119
Cdd:PRK08317  16 AVQPGDRVLDVGCGPGNDARELArRVGPEgrVVGIDRSEAMLALAKERAAglGPNVEFVR----GDADGLPFPdgSFDAV 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27808654  120 VANLPYQ-ISSPfvQKLL--LHRPL-PRYAVLMFQKEFaDRLVARPGDKDYSR 168
Cdd:PRK08317  92 RSDRVLQhLEDP--ARALaeIARVLrPGGRVVVLDTDW-DTLVWHSGDRALMR 141
PRK14968 PRK14968
putative methyltransferase; Provisional
 49-125 3.39e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 37.96  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654   49 KATDTVLEVGPGTGNLTVKMLEVAKTVIACEIDPRMIAEVKKRVMGTPLQN-KLQVNGGDVMKmewPF----FDVCVANL 123
Cdd:PRK14968  22 KKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNnGVEVIRSDLFE---PFrgdkFDVILFNP 98


                 ..
gi 27808654  124 PY 125
Cdd:PRK14968  99 PY 100
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 42-121 7.04e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 36.45  E-value: 7.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808654  42 IVEKSALKATDTVLEVGPGTGNLtvkMLEVAK----TVIACEIDPRMIAEVKKRVMGTPLQNKLQVNGGDVMKMEWP-FF 116
Cdd:COG2230  43 ILRKLGLKPGMRVLDIGCGWGGL---ALYLARrygvRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADgQF 119


                ....*
gi 27808654 117 DVCVA 121
Cdd:COG2230 120 DAIVS 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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