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Conserved domains on  [gi|121743254|sp|Q0D1P6|]
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RecName: Full=Efflux pump terG; AltName: Full=Terrein biosynthesis cluster protein terG

Protein Classification

MFS transporter( domain architecture ID 13024647)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 53-504 1.16e-123

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 366.59  E-value: 1.16e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  53 MTVCSSMFTNQLGLCNSLSTLEEIGESFGvTDPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMM 132
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFG-TSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 133 AGVSVyaGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHP-RNMGFAWFAASAPVGAMAGLLFGPLFT-MAWWPWIYW 210
Cdd:cd17476   80 AGFSP--NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAqLAWWPWIFW 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 211 SQALGVAFVFALSIVAIpnmpaeseqkqrrtileileridllggacgvtalvlfnfawnqslvatwkepyvyvclilsfl 290
Cdd:cd17476  158 FLAILAAIVAVAAIFWT--------------------------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 291 flaaffyvelrvarhpilpvavlTSDIAFVFGCTAAGWSTFGIWLFYVIRICLNIGGQTPIQMAAWLSPILVTGIGTALI 370
Cdd:cd17476  175 -----------------------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAIT 231

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 371 VGKIITKVPASSIMLFAMLCYFITSLLMALRPVHSIYWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIM 450
Cdd:cd17476  232 VGFLIARLPPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVN 311

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121743254 451 TIVVYSISLGLGFAGTIELQINnggHTKADLLHGYRGTLWFSVGLTAFGTVLAL 504
Cdd:cd17476  312 TVVNYGISIGLGIAGTVETSVN---EDGADLLKGYRAAWYLGIGLAALGLLISV 362
 
Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 53-504 1.16e-123

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 366.59  E-value: 1.16e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  53 MTVCSSMFTNQLGLCNSLSTLEEIGESFGvTDPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMM 132
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFG-TSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 133 AGVSVyaGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHP-RNMGFAWFAASAPVGAMAGLLFGPLFT-MAWWPWIYW 210
Cdd:cd17476   80 AGFSP--NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAqLAWWPWIFW 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 211 SQALGVAFVFALSIVAIpnmpaeseqkqrrtileileridllggacgvtalvlfnfawnqslvatwkepyvyvclilsfl 290
Cdd:cd17476  158 FLAILAAIVAVAAIFWT--------------------------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 291 flaaffyvelrvarhpilpvavlTSDIAFVFGCTAAGWSTFGIWLFYVIRICLNIGGQTPIQMAAWLSPILVTGIGTALI 370
Cdd:cd17476  175 -----------------------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAIT 231

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 371 VGKIITKVPASSIMLFAMLCYFITSLLMALRPVHSIYWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIM 450
Cdd:cd17476  232 VGFLIARLPPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVN 311

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121743254 451 TIVVYSISLGLGFAGTIELQINnggHTKADLLHGYRGTLWFSVGLTAFGTVLAL 504
Cdd:cd17476  312 TVVNYGISIGLGIAGTVETSVN---EDGADLLKGYRAAWYLGIGLAALGLLISV 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
47-452 1.54e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 1.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  47 RRMIFIMTVCSSMFTNQLGLCNSLSTLEEIGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWL 126
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 127 ALTSMMAGVSvyAGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-W 205
Cdd:COG2814   86 ALGSLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 206 PWIYWSQALGVAFVFALSIVAIPNMPAESEQKQRRTILEILeridllggacgvtalvlfnfawnqslvatwKEPYVYVCL 285
Cdd:COG2814  164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL------------------------------RRPRLLLLL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 286 ILSFLFLAAFFyvelrvarhpilpvavltsdiafvfgctaagwSTFGIWLFYVIRIClnigGQTPIQMAAWLSPILVTGI 365
Cdd:COG2814  214 LLAFLLGFGFF--------------------------------ALFTYLPLYLQEVL----GLSASAAGLLLALFGLGGV 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 366 GTALIVGKIITKVPASSIMLFAMLCYFITSLLMALRPVhsiyWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMG 445
Cdd:COG2814  258 LGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS----LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333


                 ....*..
gi 121743254 446 SSVIMTI 452
Cdd:COG2814  334 SGLYNSA 340
MFS_1 pfam07690
Major Facilitator Superfamily;
76-460 6.41e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.92  E-value: 6.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254   76 IGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQGLGP 155
Cdd:pfam07690  23 LAEDLGIS-PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA--SSLWLLLVLRVLQGLGA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  156 ALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWsqALGVAFVFALSIVAIPNMPAES 234
Cdd:pfam07690 100 GALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFgWRAAFL--ILAILSLLAAVLLLLPRPPPES 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  235 EQKQRRTILEILERIDLlggacgvtalvlfnfawnQSLVATWKEPYVYVCLILSFLFLAAFFYVELRVARHpilpvavlt 314
Cdd:pfam07690 178 KRPKPAEEARLSLIVAW------------------KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL--------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  315 sdiafvfgctaagwstfgiwlfyviriclnigGQTPIQMAAWLSPILVTGIGTALIVGKIITKVPASSIMLFAMLCYFIT 394
Cdd:pfam07690 231 --------------------------------GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 121743254  395 SLLMALrPVHSIYWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIMTIVVYSISLG 460
Cdd:pfam07690 279 ALGLLL-LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
PRK14995 PRK14995
SmvA family efflux MFS transporter;
87-464 1.49e-07

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 53.96  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  87 KLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVYAGYpvYILARVLQGLGPALTVPNALAIM 166
Cdd:PRK14995  42 ELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASW--LIATRALLAIGAAMIVPATLAGI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 167 GKCFSE-HPRNMGFAWFAASAPVGAMAG-LLFGPLFTMAWWPWIYWSQALGVAFVFALSIVAIPNMPAESEQKqrrtile 244
Cdd:PRK14995 120 RATFTEeKQRNMALGVWAAVGSGGAAFGpLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGRRDQP------- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 245 ilerIDLLGGACGVTALVLFNFAWNQSLVATWKEPYVYVCLILSFLFLAAFFYVELRVAR---------HPILPVAV--- 312
Cdd:PRK14995 193 ----LNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRpmidmrlftHRIILSGVvma 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 313 LTSDIAFV-FGCTAAGWSTFgiwlfyviriclnIGGQTPIQMAAWLSPILV-TGIG---TALIVGKIITKVPASSIMLFA 387
Cdd:PRK14995 269 MTAMITLVgFELLMAQELQF-------------VHGLSPLEAGMFMLPVMVaSGFSgpiAGILVSRLGLRLVATGGMALS 335

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 121743254 388 MLCYFITSLLmALRPVHSIYWTYFffatIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVimTIVVYSISLGLGFA 464
Cdd:PRK14995 336 ALSFYGLAMT-DFSTQQWQAWGLM----ALLGFSAASALLASTSAIMAAAPPEKAAAAGAI--ETMAYELGAGLGIA 405
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 96-249 4.27e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 46.16  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254   96 GLTLGTFILigGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVyaGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHPR 175
Cdd:TIGR00898 139 GVLLGSFVF--GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP--NYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQR 214

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 121743254  176 nmgfAWFAASAPVGAMAGLLFGPLftMAW----WPWIYWSQALGvAFVFALSIVAIPNMPA-ESEQKQRRTILEILERI 249
Cdd:TIGR00898 215 ----AIVGTLIQVFFSLGLVLLPL--VAYfipdWRWLQLAVSLP-TFLFFLLSWFVPESPRwLISQGRIEEALKILQRI 286
 
Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 53-504 1.16e-123

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 366.59  E-value: 1.16e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  53 MTVCSSMFTNQLGLCNSLSTLEEIGESFGvTDPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMM 132
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFG-TSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 133 AGVSVyaGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHP-RNMGFAWFAASAPVGAMAGLLFGPLFT-MAWWPWIYW 210
Cdd:cd17476   80 AGFSP--NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAqLAWWPWIFW 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 211 SQALGVAFVFALSIVAIpnmpaeseqkqrrtileileridllggacgvtalvlfnfawnqslvatwkepyvyvclilsfl 290
Cdd:cd17476  158 FLAILAAIVAVAAIFWT--------------------------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 291 flaaffyvelrvarhpilpvavlTSDIAFVFGCTAAGWSTFGIWLFYVIRICLNIGGQTPIQMAAWLSPILVTGIGTALI 370
Cdd:cd17476  175 -----------------------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAIT 231

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 371 VGKIITKVPASSIMLFAMLCYFITSLLMALRPVHSIYWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIM 450
Cdd:cd17476  232 VGFLIARLPPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVN 311

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121743254 451 TIVVYSISLGLGFAGTIELQINnggHTKADLLHGYRGTLWFSVGLTAFGTVLAL 504
Cdd:cd17476  312 TVVNYGISIGLGIAGTVETSVN---EDGADLLKGYRAAWYLGIGLAALGLLISV 362
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 73-507 1.24e-32

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 128.44  E-value: 1.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  73 LEEIGESFGvTDPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQG 152
Cdd:cd17321   19 LPTIARDLG-ASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA--PSLAFLIAARALQG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 153 LGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFT-MAWWPWIYWSQA--LGVAFVFALSIVAipn 229
Cdd:cd17321   96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLeLFGWRWIFLINVpiGLVALLLARTFSG--- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 230 mpaeseqkqrrtileileridllggacGVTALVLFNFAWnqslvatwkepyvyvcliLSFLFLAAFFYvelrvarhpilp 309
Cdd:cd17321  173 ---------------------------AVLAAFLLGAAL------------------GGLLFLLPLYL------------ 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 310 vavltsdiafvfgctaagwstfgiwlfyviricLNIGGQTPIQMAAWLSPILVTGIGTALIVGKIITKVPASSIMLFAML 389
Cdd:cd17321  196 ---------------------------------QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 390 CYFITSLLMALRPVHSIYWTyFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIMTIVVYSISLGLGFAGTI-- 467
Cdd:cd17321  243 LTAVGLLLLALLGADSSVWL-LLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALlt 321

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 121743254 468 ---------ELQINNGGHTKADLLHGYRGTLWFSVGLTAFGTVLALIFL 507
Cdd:cd17321  322 aglsanlgdSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
47-452 1.54e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 1.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  47 RRMIFIMTVCSSMFTNQLGLCNSLSTLEEIGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWL 126
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 127 ALTSMMAGVSvyAGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-W 205
Cdd:COG2814   86 ALGSLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 206 PWIYWSQALGVAFVFALSIVAIPNMPAESEQKQRRTILEILeridllggacgvtalvlfnfawnqslvatwKEPYVYVCL 285
Cdd:COG2814  164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL------------------------------RRPRLLLLL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 286 ILSFLFLAAFFyvelrvarhpilpvavltsdiafvfgctaagwSTFGIWLFYVIRIClnigGQTPIQMAAWLSPILVTGI 365
Cdd:COG2814  214 LLAFLLGFGFF--------------------------------ALFTYLPLYLQEVL----GLSASAAGLLLALFGLGGV 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 366 GTALIVGKIITKVPASSIMLFAMLCYFITSLLMALRPVhsiyWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMG 445
Cdd:COG2814  258 LGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS----LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333


                 ....*..
gi 121743254 446 SSVIMTI 452
Cdd:COG2814  334 SGLYNSA 340
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 76-338 9.28e-18

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 83.71  E-value: 9.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  76 IGESFGVTDPGkLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVyaGYPVYILARVLQGLGP 155
Cdd:COG0477   40 IAADLGASSAQ-LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP--SPELLIAARALQGIGA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 156 ALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAG-LLFGPLFTMAWWPWIYWsqalgVAFVFALSIVAIPNMPAES 234
Cdd:COG0477  117 GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGpLLGGLLVAALGWRWIFL-----INAPLGLLALVLRLRLPES 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 235 EQKQRRTILEILERIDLLGGACGVTALVLFNFAWNQSLVATWKEPYVYVCLILSFLFLAAFFYVELRVARHPILPVAVLT 314
Cdd:COG0477  192 RGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLL 271

                        250       260
                 ....*....|....*....|....
gi 121743254 315 SDIAFVFGCTAAGWSTFGIWLFYV 338
Cdd:COG0477  272 LALLLALLLLLLLLLLLLLLALLL 295
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 73-448 5.42e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 76.46  E-value: 5.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  73 LEEIGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQG 152
Cdd:cd17474   22 LPAIAEALGAS-PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS--DSFALLLAGRALQG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 153 LGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAWWPWIYWsqALGVAFVFALSIVAIPNMPA 232
Cdd:cd17474   99 IGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFF--LLAALIPVAFLAILFLLPEP 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 233 ESEQKQRRTILEILERIDLLGGacgvtalvlfnfawnqslvatwkepyvyvcLILSFLFLAAFFYVelrvarhpilpvav 312
Cdd:cd17474  177 KEKAKSSSATKLRDLKKALRGR------------------------------GLLTFLVSAFLYFF-------------- 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 313 ltsdiafvfgctaagwsTFGIWLFYVIRICLNIGGQTPIQMAAWLSPILVTGIGTALIVGKIITK-VPASSIMLFAMLCY 391
Cdd:cd17474  213 -----------------LYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLY 275

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121743254 392 FITSLLMALrpVHSIYWtyFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSV 448
Cdd:cd17474  276 ALSLLLLGF--VPSLAL--LLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328
MFS_1 pfam07690
Major Facilitator Superfamily;
76-460 6.41e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.92  E-value: 6.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254   76 IGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQGLGP 155
Cdd:pfam07690  23 LAEDLGIS-PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA--SSLWLLLVLRVLQGLGA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  156 ALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWsqALGVAFVFALSIVAIPNMPAES 234
Cdd:pfam07690 100 GALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFgWRAAFL--ILAILSLLAAVLLLLPRPPPES 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  235 EQKQRRTILEILERIDLlggacgvtalvlfnfawnQSLVATWKEPYVYVCLILSFLFLAAFFYVELRVARHpilpvavlt 314
Cdd:pfam07690 178 KRPKPAEEARLSLIVAW------------------KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL--------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  315 sdiafvfgctaagwstfgiwlfyviriclnigGQTPIQMAAWLSPILVTGIGTALIVGKIITKVPASSIMLFAMLCYFIT 394
Cdd:pfam07690 231 --------------------------------GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 121743254  395 SLLMALrPVHSIYWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIMTIVVYSISLG 460
Cdd:pfam07690 279 ALGLLL-LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 73-504 1.60e-14

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 75.31  E-value: 1.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  73 LEEIGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQG 152
Cdd:cd17503   19 LPTIMGDLGAS-LDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA--PNLASLIIFRILQG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 153 LGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWsqalgvafvfalsiVAIPnmp 231
Cdd:cd17503   96 FGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLsWRWIFY--------------INLP--- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 232 aeseqkqrrtileileridllggacgvtalvlfnfawnqslvatwkepyvyVCLILsfLFLAAFfyVELRVARHPILpva 311
Cdd:cd17503  159 ---------------------------------------------------IGILA--LLLAPL--LDLRLFKDRNF--- 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 312 vltsdIAFVFGCTAAGWSTFGIwlFYVIRICL-NIGGQTPIQMAAWLSPILVTGIGTALIVGKIITKVPASSIMLFAMLC 390
Cdd:cd17503  181 -----TLGLLLSFLLGLGLFGA--MFLLPLYLqNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 391 YFITSLLMAL----RPVHSIYWTYFFFA-------TIIATFAMdSSLPAATIIFANAVPRQYQGMGSSVIMTIVVYSISL 459
Cdd:cd17503  254 LALGTLLLAFltpdTSLWLIILPLFIRGlgmglvfMPLNTLAL-NSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 121743254 460 GLGFAGTIELQINNGGHTKADLLHGYRGTLWFSVGLTAFGTVLAL 504
Cdd:cd17503  333 RTQFHHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLAL 377
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 55-467 7.17e-14

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 73.81  E-value: 7.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  55 VCSSMFTNQLGLCNSLST-LEEIGESFGvtDPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMA 133
Cdd:cd06179    2 ALCLAYFAQLFGVTLPAAvLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 134 GVSVYAgyPVYILARVLQGLGPAlTVPNALAIMGKCFSehPRNMGFAWfaASAPVGAMAGLLFGPLF-------TMAWWP 206
Cdd:cd06179   80 GTAKSV--NMLIGGQALIGIGAG-TQGLGAAVASELVP--NKYRGLVQ--GVVNLVASPGSALGPLIagalveaNAAGWR 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 207 WIYWSQAlgVAFVFALSIVAIPNMPAESEQKQRRTILEILERIDLLGGACGVTALVLF--NFAWNQSlVATWKEPYVYVC 284
Cdd:cd06179  153 WIFYINA--IFNALALILLFFFYHPPPRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFllGLSWGGN-PYPWSSAHVIAP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 285 LILSFLFLAAFFYVELRVARHPILPVAVLTSDIAF---VFGCTAAGWSTFGIWLFYVIRICLnIGGQTPIQMAAWLSPIL 361
Cdd:cd06179  230 LVIGGVLLIAFGLYEWKGTKDGLLPPRLLFRGRNFaliLIVAFVEGMIFYSLNIFWPQQISL-LFTTDPLKAGLYQLPFG 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 362 VTGIGTALIVGKIITKVP-ASSIMLFAMLCYFITSLLMALRPVHSIywTYFFFATIIATFAMDSSLPAATIIFANAVPRQ 440
Cdd:cd06179  309 LGTLFGAILAGLLLTKIKhIKWQLVAGFVLFTAFLALLALITPDNK--ALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPE 386

                        410       420
                 ....*....|....*....|....*..
gi 121743254 441 YQGMGSSVIMTIVVYSISLGLGFAGTI 467
Cdd:cd06179  387 DIGTASGLLGSARALGGAVGTAIFTSI 413
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 73-504 1.08e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 69.50  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  73 LEEIGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVyaGYPVYILARVLQG 152
Cdd:cd17324   22 LPDIARDFGVS-VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP--SFALLLLARALAG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 153 LGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWSQALGVAFVFALSIVAIPNMP 231
Cdd:cd17324   99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLgWRAAFLAIAVLALLAALLLWRLLPSLP 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 232 AESEQkqrrtileileridllggacgvtalvlfNFAWNQSLVATWKEPYVYVCLILSFLFLAAFFyvelrvarhpilpva 311
Cdd:cd17324  179 PKKPG----------------------------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFF--------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 312 vltsdiafvfgctaAGWSTFGIWLFyviriclNIGGQTPIQMAAWLSPILVTGIGTALIVGKIITKVPASSIMLFAMLCY 391
Cdd:cd17324  216 --------------ALYTYLAPFLT-------DVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 392 FITSLLMALrpvhSIYWTYFFFATIIATFAMDSSLPAATIIFANAVPRQyQGMGSSVIMTIVVYSISLGLGFAGTIelqI 471
Cdd:cd17324  275 AALLLLTLL----GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLV---L 346

                        410       420       430
                 ....*....|....*....|....*....|...
gi 121743254 472 NNGghtkadllhGYRGTLWFSVGLTAFGTVLAL 504
Cdd:cd17324  347 DHG---------GWAGVGWVGAALLLLALLLAL 370
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 76-450 1.84e-12

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 68.36  E-value: 1.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  76 IGESFGvtDPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVyaGYPVYILARVLQGLGP 155
Cdd:cd17502   22 IVAEFG--GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP--NMTMLIVGRAIQGIGG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 156 ALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWSqalgvafvfalsivaipNMPaes 234
Cdd:cd17502   98 GGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLsWRWCFYI-----------------NLP--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 235 eqkqrrtileileridllggaCGVTALVLFnfawnqslvatwkePYVYVCLILSFLFLAAFFyvelrvarhpilpvavlt 314
Cdd:cd17502  158 ---------------------IGGLALALL--------------RTILLSSIFGFLFGGALF------------------ 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 315 sdiafvfgctaagwstfgIWLFYVIRICLNIGGQTPIQMAAWLSPILVTGIGTALIVGKIITKVP-ASSIMLFAMLCYFI 393
Cdd:cd17502  185 ------------------GLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMSV 246

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121743254 394 TSLLMALRPVHSIYWTYFFFaTIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIM 450
Cdd:cd17502  247 GAGLLTTLTLDTSKWLLIGY-LILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNT 302
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
49-512 2.86e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.97  E-value: 2.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  49 MIFIMTVCSSMFTNQLGLcnslsTLEEIGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLAL 128
Cdd:COG2271   14 LLFLAYFLNYLDRSNLSV-----AAPPLQADLGLS-AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 129 TSMMAGVSvyAGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAM-AGLLFGPLFTMAWWPW 207
Cdd:COG2271   88 ATLLFGFA--TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGAlAPPLLGWLLAAFGWRA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 208 IYWSQALGVAFVFALSIVAipnmpaeseqkqrrtileileridllggacgvtalvlfnfawnqslvatwkepyvyvclil 287
Cdd:COG2271  166 AFLILGLPGLLLALLRFWL------------------------------------------------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 288 sflflaaffyvelrvarhpilpvavltsdIAFVFGCTAAGWSTFGIWLfyvIRICLNIGGQTPIQMAAWLSPILVTGIGT 367
Cdd:COG2271  185 -----------------------------LALAYFLVYFALYGFLTWL---PTYLVEVRGLSLAQAGLLLSLPFLAGIVG 232

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 368 ALIVGKIITKVPASSIMLFAMLCYFITSLLMALRPVHSIYWTYFFFatIIATFAMDSSLPAATIIFANAVPRQYQGMGSS 447
Cdd:COG2271  233 SLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALL--FLAGFGLGGAFGLLWALAAELFPKKARGTASG 310

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121743254 448 VIMTIVVYSISLGLGFAGTIelqinngghtkADlLHGYRGTLWFSVGLTAFGTVLALIFLLKDLR 512
Cdd:COG2271  311 LVNTFGFLGGALGPLLVGYL-----------LD-ATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 78-507 3.27e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 67.99  E-value: 3.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  78 ESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQGLGPAL 157
Cdd:cd17325   24 ESLGAS-VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA--TSYWQLLLARFLQGLASAA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 158 TVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWSQALGVAFVFALSIVAIPNMPAESEQ 236
Cdd:cd17325  101 VWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALgYRAPFLVCAALALLALVLALLLLPEPRPPPNK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 237 KQRRTILEILERIDLLggacgvtalvlfnfawnqslvatwKEPYVYVCLILSFLFLAAFfyvelrVARHPILPVAVltsd 316
Cdd:cd17325  181 RAVSAARLRSGLRLLL------------------------RDRRLLALFLAIFVLAFAF------GALEPFLPLYA---- 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 317 iafvfgctaagwstfgiwlfyviricLNIGGQTPIQMAAWLSPILVTGIGTALIVGKIITKVPASSIMLFAMLCYFITSL 396
Cdd:cd17325  227 --------------------------AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 397 LMALRPVhsiyWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIMTIvvYSISLGLG--FAGTIelqinng 474
Cdd:cd17325  281 LLPLATS----FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA--FSLGMVLGplLGGFL------- 347

                        410       420       430
                 ....*....|....*....|....*....|...
gi 121743254 475 ghtkADLLhGYRGTLWFSVGLTAFGTVLALIFL 507
Cdd:cd17325  348 ----YDAF-GFATPFLAAAALLLLAAVLFLLLR 375
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 73-228 7.37e-12

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 66.83  E-value: 7.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  73 LEEIGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQG 152
Cdd:cd17504   19 LPTIQREFGTS-AAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA--PNLPVLIAGRALQG 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 121743254 153 LGPALtVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFG-PLFTMAWWPWIYWSqalgVAFVFALSIVAIP 228
Cdd:cd17504   96 IGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGgWIVQHLGWRWIFWT----AAPVAVLLAALVP 167
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
76-514 3.51e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.74  E-value: 3.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  76 IGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVyaGYPVYILARVLQGLGP 155
Cdd:COG2223   31 LAEEFGLS-AAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV--SYWLLLLLGLLLGIGG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 156 ALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWSQALGVAFVFALSIVAIPNMPAES 234
Cdd:COG2223  108 GGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDPPAGA 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 235 EQKQRRTILEILEridllggacgvtalvlfnfawnqslvaTWKEPYVYVclilsflflaaffyvelrvarhpilpvavlt 314
Cdd:COG2223  188 AAAAKASLRDQLE---------------------------ALRDPRFWL------------------------------- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 315 sdIAFVFGCTAAGWSTFGIWLFYVIRiclNIGGQTPIQMAAWLSPILVTGIGTALIVGKIITKVPASSIMLFAMLCYFIT 394
Cdd:COG2223  210 --LSLLYFGTFGSFIGFSSWLPPYLV---DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 395 SLLMALrPVHSIYWTYFFFATIIATFAMDSSLPAATIifANAVPRQYQGMGSSVIMTIVvysiSLGLGFAGTIelqinnG 474
Cdd:COG2223  285 LLLLAL-ALGSLWLFLVLFLLLGLALGGGNGAVFALV--PDIFPTKNAGAVYGLVGAAG----GLGGFLGPLL------F 351

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 121743254 475 GHTKaDLLHGYRGTLWFSVGLTAFGTVLALIFLLKDLRRR 514
Cdd:COG2223  352 GALL-DATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 84-418 6.57e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 57.82  E-value: 6.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  84 DPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSmmAGVSVYAGYPVYILARVLQGLGPALTVPNAL 163
Cdd:cd06174   29 SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA--LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 164 AIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW---WPWIYWSQALGVAFVFALSIVAIPNMP-AESEQKQR 239
Cdd:cd06174  107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfgWRAVFLIAAALALLAAILLLLVVPDPPeSARAKNEE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 240 RTILEILERIDLLGGACGVTALVLFNFAWN---------------QSLVATWKEPYVYVCLILSFLFLAAFFYVELRVAR 304
Cdd:cd06174  187 ASSKSVLKLLKRVLKNPGLWLLLLAIFLVNlayysfstllplfllDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 305 HPILPVAVLTSDIAFVFGCTAAGWSTFGIWLFYVIRICLNIGGQTPIQMAAWLSPILVTGIGTALivgkiitkvpaSSIM 384
Cdd:cd06174  267 IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF-----------GLLN 335

                        330       340       350
                 ....*....|....*....|....*....|....
gi 121743254 385 LFAMLCYFITSLLMALRPVHSIYWTYFFFATIIA 418
Cdd:cd06174  336 TFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVL 369
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 73-225 1.36e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 56.86  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  73 LEEIGESFGVTDpgklswtisGYGLTLGT-FIL-------IGGRLGDEFGNKAIFVIGMG-WLAltsMMAGVSVYAGYPV 143
Cdd:cd17328   22 LPDIQSDFLIDD---------SLAGLLQTvFIIsymvlspIFGYLGDRYNRKWILAVGILiWSA---ATLLSSFAPNFWQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 144 YILARVLQGLGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAWWPW---IYWSQALGVAFVF 220
Cdd:cd17328   90 LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWrwaFRVTGVLGVLLAI 169


                 ....*
gi 121743254 221 ALSIV 225
Cdd:cd17328  170 LLLLF 174
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 70-228 1.47e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 53.73  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  70 LSTLEEIGESFGVtDPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVyaGYPVYILARV 149
Cdd:cd17320   19 LPALPAIARDLGA-SASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS--SIEQLLIARF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 150 LQGLGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWSQALGVAFVFALSIVAIP 228
Cdd:cd17320   96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFgWRAIFVFLALLGLLLLLLVLLFLP 175
PRK14995 PRK14995
SmvA family efflux MFS transporter;
87-464 1.49e-07

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 53.96  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  87 KLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVYAGYpvYILARVLQGLGPALTVPNALAIM 166
Cdd:PRK14995  42 ELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASW--LIATRALLAIGAAMIVPATLAGI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 167 GKCFSE-HPRNMGFAWFAASAPVGAMAG-LLFGPLFTMAWWPWIYWSQALGVAFVFALSIVAIPNMPAESEQKqrrtile 244
Cdd:PRK14995 120 RATFTEeKQRNMALGVWAAVGSGGAAFGpLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGRRDQP------- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 245 ilerIDLLGGACGVTALVLFNFAWNQSLVATWKEPYVYVCLILSFLFLAAFFYVELRVAR---------HPILPVAV--- 312
Cdd:PRK14995 193 ----LNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRpmidmrlftHRIILSGVvma 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 313 LTSDIAFV-FGCTAAGWSTFgiwlfyviriclnIGGQTPIQMAAWLSPILV-TGIG---TALIVGKIITKVPASSIMLFA 387
Cdd:PRK14995 269 MTAMITLVgFELLMAQELQF-------------VHGLSPLEAGMFMLPVMVaSGFSgpiAGILVSRLGLRLVATGGMALS 335

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 121743254 388 MLCYFITSLLmALRPVHSIYWTYFffatIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVimTIVVYSISLGLGFA 464
Cdd:PRK14995 336 ALSFYGLAMT-DFSTQQWQAWGLM----ALLGFSAASALLASTSAIMAAAPPEKAAAAGAI--ETMAYELGAGLGIA 405
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
181-529 7.34e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.44  E-value: 7.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 181 WFAASAPVGAMAGLLFGPLFTMAWWPWIYWSQALGVAFVFALSIVAIPN--MPAE--SEQKQRRTILEILERIDLLGGAC 256
Cdd:COG2211   83 WILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYsaLGAEltPDYEERTRLSSWRFAFAGLGGLL 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 257 GVTALVLFNFAWNQSLVATWKEPYVYVCLILSFLFLAAFFYV-ELRVARHPILPVAVLTSDIA------FVFGCTAAGWS 329
Cdd:COG2211  163 ASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTkERPVPEEEKVSLKESLKALLknrpflLLLLAYLLFFL 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 330 TFGIWLFYVIRICLNIGGQTPIQMAAWLSPILVTGIGTALIVGKIITKVPASSIMLFAMLCYFITSLLMALRPVHSIYWt 409
Cdd:COG2211  243 ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWL- 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 410 yFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMG---SSVIMTIVVYSISLGLGFAGTIELQI------NNGGHTKAD 480
Cdd:COG2211  322 -LLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGrrrEGLYFGIFTFAIKLGQALAGALAGLLlalfgyVAGAAQSPS 400

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 121743254 481 LLHGYRGTLWFsvgLTAFGTVLALIFLLK-DLRRRKLARTQVEEEKGHSS 529
Cdd:COG2211  401 ALTGIRLLFFL---LPAVLLLLAALLLLFyPLTRERHAEIRAELAARRAA 447
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 73-224 9.56e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.03  E-value: 9.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  73 LEEIGESFGVTDPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMgWLALTSMMAGVsVYAGYPVYILARVLQG 152
Cdd:cd17473   22 LPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGL-LLYGIGGVAGL-FLDSLYALLASRALLG 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121743254 153 LGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLF-GPLFTMAW-WPWIYWSQALGVAFVFALSI 224
Cdd:cd17473  100 IGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLgGALAEIGWrAPFLVYLLALPVLILVLLFL 173
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 88-228 1.49e-06

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 50.25  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  88 LSWTISGYGLTLGTFI-------LIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVYAGYPVYILARVLQGLGPALTVP 160
Cdd:cd17380   29 FGWSKTDQGLVLSSFFwgyaltqVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 161 NALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGP-LFTMAWWPWI-YWSQALGVAFVFALSIVAIP 228
Cdd:cd17380  109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPlLLEYYGWPSVfYFFGLLGLLWALVWLIYLPP 178
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 92-338 1.50e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 50.29  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  92 ISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVYAgyPVYILARVLQGLGPALTVpnALAIMGKCFS 171
Cdd:cd17472   38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSI--YGLILGRALQGSGAISSV--VMALLADLTR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 172 EHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWSQALGVAFVFALSIVAIPNMP--AESEQKQRRTILEILER 248
Cdd:cd17472  114 EENRTKAMALIGASIGIAFAISMVLGPLLAAHLgVSGLFLITAILSLVSLLILLFFVPDPPkiVQISEKEKKKLKKLLKN 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 249 IDLLGGACGVTAL--------VLFNFAWNQSLVATWKEPYVYVCLILSFLFLAAFF--YVELRVARHPILPVAVLTSDIA 318
Cdd:cd17472  194 KRLLRLDFSIFILhfvlmaffYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFviYAEKKGKMKQVFVSSILLIAVG 273

                        250       260
                 ....*....|....*....|...
gi 121743254 319 FV---FGCTAAGWSTFGIWLFYV 338
Cdd:cd17472  274 FLlllFAATSLWLLIIGLIIFFI 296
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 86-228 3.67e-06

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 49.15  E-value: 3.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  86 GKLSWTISGYGLTLGTFI-------LIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVYAGYPVYILARVLQGLGPALT 158
Cdd:cd17318   49 PEFDWSEKTQGIILSSFFygyiltqIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVT 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121743254 159 VPNALAIMGKCFSEHPRNMGFAWFAASAPVG-AMAGLLFGPLFTMAWWPWIYW-SQALGVAFVFALSIVAIP 228
Cdd:cd17318  129 FPAMHALWAKWAPPLERSRLTSIAYSGSQFGtVIAMPLSGFLCESLGWPSIFYiFGGLGLLWCLLWFFLVLP 200
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 96-249 4.27e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 46.16  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254   96 GLTLGTFILigGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVyaGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHPR 175
Cdd:TIGR00898 139 GVLLGSFVF--GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP--NYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQR 214

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 121743254  176 nmgfAWFAASAPVGAMAGLLFGPLftMAW----WPWIYWSQALGvAFVFALSIVAIPNMPA-ESEQKQRRTILEILERI 249
Cdd:TIGR00898 215 ----AIVGTLIQVFFSLGLVLLPL--VAYfipdWRWLQLAVSLP-TFLFFLLSWFVPESPRwLISQGRIEEALKILQRI 286
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 51-230 4.81e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 45.64  E-value: 4.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  51 FIMTVCSSMFTnqlglcnslSTLEEIGESFGVTDPGKLSwTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTS 130
Cdd:cd17323    9 FVVTFGSSIYS---------PALPQIAEDFHVSEEVANL-GVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 131 MMAGVSVyaGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIY 209
Cdd:cd17323   79 IGCALAP--NIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLgWRWIF 156

                        170       180
                 ....*....|....*....|.
gi 121743254 210 WSQALGVAFVFALSIVAIPNM 230
Cdd:cd17323  157 WFLAIISGFCLILIFLFLPIV 177
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 28-371 8.45e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 45.43  E-value: 8.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254   28 GLQTAGDEyvyIADHYGMVRRMI-----FIMTVCSSMFTNQLglcnSLSTLEEIGESFGVTDPGKLSWTISGYGLTLGtf 102
Cdd:pfam06609  24 ALATSAAE---LPDGYYRSPRIIasfaaFSLNVCATYFVLQA----SASALPNILQDIGQSENQGLFSTLWTMGQAVS-- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  103 ILIGGRLGDEFGNKAiFVIGMGWLALTSMMAGVSVyAGYPVYILARVLQGL--GPALTVPnalAIMGKCFSEHPRNMGFa 180
Cdd:pfam06609  95 ILMMGRLTDRFGRRP-FVIATHIIGLVGAIVGCTA-NKFNTLLAAMTLLGVaaGPAGASP---LFIGELMSNKTKFLGL- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  181 wFAASAPVGAMAGLlfGPLF-----TMAWWPWIYWSQALGVAFVFALSIVAI--PNMPAESEQKQRRTilEILERIDLLG 253
Cdd:pfam06609 169 -LIVSAPTIAMNGA--GPYFgqrlaIQGNWRWIFYIYIIMSAIAVLLIIIWYhpPSFAQLHGKKARKR--DELAKLDWIG 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  254 GACGV--TALVLFNFAWNQSLVATWKEPYVyVCLILS---FLFLAAFFYVELRVARhPILPVAVLTSDIAFV---FGCTA 325
Cdd:pfam06609 244 IFLVIagTSLFLLGVSWGGKPNNPWNSAKI-IGLISSgagSLVIFALYEVFGKPEQ-PIIPPALFKDTRGFVcilIISSI 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 121743254  326 AGWSTFGIWLFYVIRIcLNIGGQT--PIQMAAWLSPILVTGIGTALIV 371
Cdd:pfam06609 322 MGAMHLCLTIIYPQQV-INIFGSSlkNWEETAWMSATASFGTGAGVMI 368
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 104-227 3.62e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.97  E-value: 3.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 104 LIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSVyaGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHPRNMGFAWFA 183
Cdd:cd17316   54 LLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP--TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQ 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 121743254 184 ASAPVGAMAGLLFGPLFTMAWWPWIYWSQALGVAFVFALSIVAI 227
Cdd:cd17316  132 SGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL 175
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
73-240 7.09e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.17  E-value: 7.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  73 LEEIGESFGVTdPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALTSMMAgvSVYAGYPVYILARVLQG 152
Cdd:COG2807   41 LPEIRADLGLS-ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR--SLAPSVALLLAGTALIG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 153 LGPALTVPNALAIMGKCFSEHpRNMGFAWFAASAPVGAMAGLLFGPLFTMAW-WPWIYWSQALGVAFVFALSIVAIPNMP 231
Cdd:COG2807  118 AGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALgWRGALAVWALLALLALLLWLPLLRRRP 196


                 ....*....
gi 121743254 232 AESEQKQRR 240
Cdd:COG2807  197 AAAAAAPAA 205
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 84-246 1.41e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 41.10  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  84 DPGKLSW--TISGYGLTLGTFIliGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQGLGPALTVPN 161
Cdd:PRK11551  48 DVAQMGWafSAGILGLLPGALL--GGRLADRIGRKRILIVSVALFGLFSLATAQA--WDFPSLLVARLLTGVGLGGALPN 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 162 ALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTM-AWWPWIYWSQALGVAFVFALSIVAIPNMPA----ESEQ 236
Cdd:PRK11551 124 LIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGdAAWRHIFYVGGVGPLLLVPLLMRWLPESRAfaqaAGAG 203

                        170
                 ....*....|
gi 121743254 237 KQRRTILEIL 246
Cdd:PRK11551 204 KQRAPVLRAL 213
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 98-275 1.51e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  98 TLGTFI--LIGGRLGDEFGNKAIFVIGMGWLALTSMMAGVSvyAGYPVYILARVLQGLGPALTVPNALAIMGKCFSEHPR 175
Cdd:cd17489   41 TLAALLarPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA--TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 176 NMGFAWFAASAPVGAMAGLLFGPLFTMAwwpWIYWSQALGVAFVFALSIVAIPNMPAESEQKQRRTILEILERIDLLGGA 255
Cdd:cd17489  119 GEGIGYYGLATTLAMALGPALGLFLYQH---LGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK 195

                        170       180
                 ....*....|....*....|
gi 121743254 256 CGVTALVLFNFAWNQSLVAT 275
Cdd:cd17489  196 VLPPALILFLASIAYGAIST 215
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 233-457 1.87e-03

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 40.75  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 233 ESEQKQRRTILEILERIDLLGG---ACGVTaLVLFNFAWNQSLVATWKEPYVYVCLILSFLFLAAFFYVELRVARHPILP 309
Cdd:cd17322  200 EQTGGLSQNLVKLFWKLDIFGVillTAGLG-LILVPLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 310 VaVLTSDIAFVFGCTAA-----GWSTFGIWLFYVIRICLNiggqTPIQMAAWLSPILVTGIGTALI-VGKIITKVPASSI 383
Cdd:cd17322  279 F-RLLKDRTILAACLIDffyffSYYIFSDYLYTVLQVAVG----ESITSATRITNLYSFVSTVAGIfVGFLIRKTRRYKV 353

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121743254 384 MLFA-MLCYFITSLLMALRPVHSIYWTYFFFATIIATFAMDSSLPAATIIFANAVPRQYQGMGSSVIMTivVYSI 457
Cdd:cd17322  354 LVIIgVPLYIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLT--VYSI 426
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-190 2.94e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  84 DPGKLSWTISGYGLTLGTFILIGGRLGDEFGNKAIFVIGMGWLALtsMMAGVSVYAGYPVYILARVLQGLGPALTVPNAL 163
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL--GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                         90       100
                 ....*....|....*....|....*..
gi 121743254 164 AIMGKCFSEHPRNMGFAWFAASAPVGA 190
Cdd:COG2814  319 ALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 82-268 3.42e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.90  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  82 VTDPGKLSWTISGYGLTLGTFI-----LIGGRLGDEFGNKAIFVIGMgwLALTSMMAGVSVYAGYPVYILARVLQGLGPA 156
Cdd:cd17329   26 LHQQLGLSASIVGLVLALSAVAgivasLIGGRLADRFGRKPVMLAGL--LLRALGFALLGFAHSPWLFAIALVLTGFGGG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 157 LTVPNALAIMGKCFSEHPRNMGFAWFAASAPVGAMAGLLFGPLFTMAWWPWIYWsqALGVAFVFALSIVAIpNMPAESEQ 236
Cdd:cd17329  104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFL--AAAVLFLLAALVLLF-LLPETRPK 180

                        170       180       190
                 ....*....|....*....|....*....|..
gi 121743254 237 KQRRTILEILERIDLLGGACGVTALVLFNFAW 268
Cdd:cd17329  181 RRAAEKTEILRGYKIVLRDRAFLLFLLASFLI 212
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 96-231 5.68e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 39.57  E-value: 5.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254   96 GLTLGTFILigGRLGDEFGNKAIFVIGMgwlALTSMMAGVSVYA-GYPVYILARVLQGLGPALTVPNALAIMGKCFSEHP 174
Cdd:TIGR01299 214 GMMVGAFFW--GGLADKLGRKQCLLICL---SVNGFFAFFSSFVqGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEK 288

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121743254  175 RNMGFAWFAASAPVGAMAGLlfgplfTMAWW--PWIYWSQALGVAF------VFAL--------SIVAIPNMP 231
Cdd:TIGR01299 289 RGEHLSWLCMFWMIGGIYAA------AMAWAiiPHYGWSFQMGSAYqfhswrVFVIvcafpcvfAIGALTFMP 355
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 88-222 5.81e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.09  E-value: 5.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254  88 LSWTISGYGLTLGTFIL-------IGGRLGDEFG-NKAIFVIGMGWLALTSMMAGVSvyaGYPVYILARVLQGLGPALTV 159
Cdd:cd17319   33 LGLSPTQYGLIASAFFLgyalfqvPGGWLLDRFGaRKVLAVSMLLWSLFTALTGFAT---SLTSLYVLRFLLGVAEAGFF 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121743254 160 PNALAIMGKCFSEHPRNMGFAWFAASAPVGAM-AGLLFGPLFTMAWWPWIYWSQALgVAFVFAL 222
Cdd:cd17319  110 PGAIKALAEWFPARERGRATGLFNSGAPLGAAiGPPLSGWLLLLFGWRWAFIIEGL-LGLLLAV 172
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 104-267 5.95e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.14  E-value: 5.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 104 LIGGRLGDEFGNKAIFVIGMgwLALTSMMAGVSVYAGYPVYILARVLQGLGPAlTVPNA--LAIMGKcFSEHPRNMGFAW 181
Cdd:cd17475   49 LPAGWLLDRFGERRVLAVGL--LLMGAAALLMALVGSYPVLLVLLFLVGAGYG-SVQPGggRAIMRW-FPPRERGLAMGI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121743254 182 FAASAPVG-AMAGLLFGPLFTMAWWPWIYWSQAL-----GVAFVFALSIVAIPNMPAESEQKQRRTILEILERIDLLGGA 255
Cdd:cd17475  125 RQTGVPLGgALAAALLPPLALHYGWRAAFVVAGLvsilaAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIA 204

                        170
                 ....*....|..
gi 121743254 256 CGVTALVLFNFA 267
Cdd:cd17475  205 IAGALLVAPQFA 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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