|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00491 |
PTZ00491 |
major vault protein; Provisional |
4-850 |
0e+00 |
|
major vault protein; Provisional
Pssm-ID: 240439 [Multi-domain] Cd Length: 850 Bit Score: 1181.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 4 EEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRL 83
Cdd:PTZ00491 3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 84 RHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEII 163
Cdd:PTZ00491 83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 164 QATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRD-FRGVS 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDvYGGIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 243 RRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLE-QGIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEgDGIQ 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 322 DVYVLSEQQGLLLRAlqpLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRA---LETFTDEDGVEREPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 402 IGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLAD-------RGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAQPRSSMAYsersgqaSGKVPYEENPGFESHRDKHRVVTYKVPHNAAVQLYDYK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 475 EKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKD 554
Cdd:PTZ00491 480 TKKSRVVFGPDLVMLEPDEEFTVLSLSGGKPKVPNQIHSLHLFLGPDFMTDVIHVETSDHARLALQLSYNWYFDV-TDGN 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 555 PQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGF--ETSEakgpdgmalprPRDQAVFPQNG 632
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFGSndETGE-----------VRDSLRFPANN 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 633 LVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAL 712
Cdd:PTZ00491 628 LVITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAE 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 713 SMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEV 792
Cdd:PTZ00491 708 SAAVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEA 787
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 21542417 793 KKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG 850
Cdd:PTZ00491 788 TKFERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
|
|
| MVP_shoulder |
cd08825 |
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ... |
509-670 |
2.14e-85 |
|
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.
Pssm-ID: 259807 Cd Length: 151 Bit Score: 269.48 E-value: 2.14e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 509 HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKdPQETAKLFSVPDFVGDACKAIASRVRGAVASVTF 588
Cdd:cd08825 1 NQIKALCLLLGPDFMTDIITVETADHARLQLQLAYNWHFDVDDKK-PEEAAKLFSVPDFIGDACKAIASRIRGAVASVTF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 589 DDFHKNSARIIRTAVFGFetsEAKGPDgmalprpRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNS 668
Cdd:cd08825 80 DDFHKNSARIIRSAVFGD---DEKGEV-------RDELRFPANNLVITNVDIQSVEPVDQRTRDSLQKSVQLAIEITTNS 149
|
..
gi 21542417 669 QE 670
Cdd:cd08825 150 QE 151
|
|
| MVP_shoulder |
pfam11978 |
Shoulder domain; This domain is found in the Major Vault Protein and has been called the ... |
519-647 |
6.32e-61 |
|
Shoulder domain; This domain is found in the Major Vault Protein and has been called the shoulder domain. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.
Pssm-ID: 463418 Cd Length: 118 Bit Score: 202.09 E-value: 6.32e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 519 GPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARI 598
Cdd:pfam11978 1 GPDFMTDIITVETADHARLQLQLSYNWHFDV-DDGDPEDAAKLFSVPDFVGDACKAIASRIRGAVASVTFDDFHKNSAKI 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 21542417 599 IRTAVFGFetsEAKGpdgmalpRPRDQAVFPQNGLVVSSVDVQSVEPVD 647
Cdd:pfam11978 80 IRRAVFGV---DENG-------EVRDSLLFPENNLVITSVDVQSVEPVD 118
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
653-784 |
1.41e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 42.62 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 653 ALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEA 732
Cdd:COG1196 442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 21542417 733 arIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKA 784
Cdd:COG1196 522 --LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA 571
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00491 |
PTZ00491 |
major vault protein; Provisional |
4-850 |
0e+00 |
|
major vault protein; Provisional
Pssm-ID: 240439 [Multi-domain] Cd Length: 850 Bit Score: 1181.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 4 EEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRL 83
Cdd:PTZ00491 3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 84 RHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEII 163
Cdd:PTZ00491 83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 164 QATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRD-FRGVS 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDvYGGIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 243 RRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLE-QGIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEgDGIQ 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 322 DVYVLSEQQGLLLRAlqpLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRA---LETFTDEDGVEREPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 402 IGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLAD-------RGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAQPRSSMAYsersgqaSGKVPYEENPGFESHRDKHRVVTYKVPHNAAVQLYDYK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 475 EKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKD 554
Cdd:PTZ00491 480 TKKSRVVFGPDLVMLEPDEEFTVLSLSGGKPKVPNQIHSLHLFLGPDFMTDVIHVETSDHARLALQLSYNWYFDV-TDGN 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 555 PQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGF--ETSEakgpdgmalprPRDQAVFPQNG 632
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFGSndETGE-----------VRDSLRFPANN 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 633 LVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAL 712
Cdd:PTZ00491 628 LVITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAE 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 713 SMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEV 792
Cdd:PTZ00491 708 SAAVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEA 787
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 21542417 793 KKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG 850
Cdd:PTZ00491 788 TKFERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
|
|
| MVP_shoulder |
cd08825 |
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ... |
509-670 |
2.14e-85 |
|
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.
Pssm-ID: 259807 Cd Length: 151 Bit Score: 269.48 E-value: 2.14e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 509 HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKdPQETAKLFSVPDFVGDACKAIASRVRGAVASVTF 588
Cdd:cd08825 1 NQIKALCLLLGPDFMTDIITVETADHARLQLQLAYNWHFDVDDKK-PEEAAKLFSVPDFIGDACKAIASRIRGAVASVTF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 589 DDFHKNSARIIRTAVFGFetsEAKGPDgmalprpRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNS 668
Cdd:cd08825 80 DDFHKNSARIIRSAVFGD---DEKGEV-------RDELRFPANNLVITNVDIQSVEPVDQRTRDSLQKSVQLAIEITTNS 149
|
..
gi 21542417 669 QE 670
Cdd:cd08825 150 QE 151
|
|
| MVP_shoulder |
pfam11978 |
Shoulder domain; This domain is found in the Major Vault Protein and has been called the ... |
519-647 |
6.32e-61 |
|
Shoulder domain; This domain is found in the Major Vault Protein and has been called the shoulder domain. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.
Pssm-ID: 463418 Cd Length: 118 Bit Score: 202.09 E-value: 6.32e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 519 GPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARI 598
Cdd:pfam11978 1 GPDFMTDIITVETADHARLQLQLSYNWHFDV-DDGDPEDAAKLFSVPDFVGDACKAIASRIRGAVASVTFDDFHKNSAKI 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 21542417 599 IRTAVFGFetsEAKGpdgmalpRPRDQAVFPQNGLVVSSVDVQSVEPVD 647
Cdd:pfam11978 80 IRRAVFGV---DENG-------EVRDSLLFPENNLVITSVDVQSVEPVD 118
|
|
| Vault_2 |
pfam17794 |
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the ... |
50-109 |
9.36e-30 |
|
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to pfam01505.
Pssm-ID: 407666 [Multi-domain] Cd Length: 60 Bit Score: 112.18 E-value: 9.36e-30
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 50 MVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDI 109
Cdd:pfam17794 1 MITLPPRSYCVVANPVSRDGKGSPVLDQHGQVRLVHGDKEIRLAQDPFPLYPGEKLEGDI 60
|
|
| Vault_3 |
pfam17795 |
Major Vault Protein Repeat domain; This domain is found in the Major Vault Protein. |
457-518 |
2.00e-28 |
|
Major Vault Protein Repeat domain; This domain is found in the Major Vault Protein.
Pssm-ID: 407667 Cd Length: 62 Bit Score: 108.31 E-value: 2.00e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21542417 457 VVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLL 518
Cdd:pfam17795 1 VVTFRVPHNALVQLYDYKTKKSRVVFGPLLVSLEPHEHFTVLSLSGGQPKEPNAIHSLCLYL 62
|
|
| Vault_4 |
pfam17796 |
Major Vault Protein repeat domain; |
379-439 |
7.10e-24 |
|
Major Vault Protein repeat domain;
Pssm-ID: 407668 [Multi-domain] Cd Length: 61 Bit Score: 95.37 E-value: 7.10e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21542417 379 AIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGE 439
Cdd:pfam17796 1 AIPLDENEGIYVRNIRTGEVRVVTGQTYMLTESEELWEKELPPGVEVLLAEARDPLAGRDS 61
|
|
| Vault |
pfam01505 |
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ... |
113-153 |
1.09e-15 |
|
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Pssm-ID: 460235 [Multi-domain] Cd Length: 41 Bit Score: 71.31 E-value: 1.09e-15
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 21542417 113 QVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIP 153
Cdd:pfam01505 1 YVLSENEALRLRALEDFTDRDGVERKAGEEWLVRGPGTYIP 41
|
|
| Vault |
pfam01505 |
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ... |
166-206 |
2.62e-14 |
|
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Pssm-ID: 460235 [Multi-domain] Cd Length: 41 Bit Score: 67.46 E-value: 2.62e-14
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 21542417 166 TIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLP 206
Cdd:pfam01505 1 YVLSENEALRLRALEDFTDRDGVERKAGEEWLVRGPGTYIP 41
|
|
| Vault |
pfam01505 |
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ... |
324-367 |
7.86e-12 |
|
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Pssm-ID: 460235 [Multi-domain] Cd Length: 41 Bit Score: 60.52 E-value: 7.86e-12
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 21542417 324 YVLSEQQGLLLRALqplEEGEDEEKVSHQAGDHWLIRGPLEYVP 367
Cdd:pfam01505 1 YVLSENEALRLRAL---EDFTDRDGVERKAGEEWLVRGPGTYIP 41
|
|
| Vault |
pfam01505 |
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ... |
220-261 |
1.10e-11 |
|
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Pssm-ID: 460235 [Multi-domain] Cd Length: 41 Bit Score: 60.14 E-value: 1.10e-11
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 21542417 220 ILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTvqDTEAHVP 261
Cdd:pfam01505 2 VLSENEALRLRALEDFTDRDGVERKAGEEWLVR--GPGTYIP 41
|
|
| SPFH_like |
cd02106 |
core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model ... |
525-619 |
3.52e-09 |
|
core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons, and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, and in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.
Pssm-ID: 259797 [Multi-domain] Cd Length: 110 Bit Score: 55.06 E-value: 3.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 525 DVITIETADHARLQLQLAYNWHFEVNDRKDpqETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNsARIIRTAVF 604
Cdd:cd02106 8 RVEPVGTADGVPVAVDLVVQFRITDYNALP--AFYLVDFVKDIKADIRRKIADVLRAAIGRMTLDQIISG-RDEIAKAVK 84
|
90
....*....|....*
gi 21542417 605 GFETsEAKGPDGMAL 619
Cdd:cd02106 85 EDLE-EDLENFGVVI 98
|
|
| Vault_2 |
pfam17794 |
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the ... |
273-320 |
6.39e-09 |
|
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to pfam01505.
Pssm-ID: 407666 [Multi-domain] Cd Length: 60 Bit Score: 52.86 E-value: 6.39e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 273 ITTLGPHNYCVILDPVGPDGK-----NQLGQKRVVKGEKS-------FFLQPGEQLEQGI 320
Cdd:pfam17794 1 MITLPPRSYCVVANPVSRDGKgspvlDQHGQVRLVHGDKEirlaqdpFPLYPGEKLEGDI 60
|
|
| MVP_shoulder |
cd08825 |
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ... |
800-888 |
4.68e-08 |
|
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.
Pssm-ID: 259807 Cd Length: 151 Bit Score: 53.00 E-value: 4.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 800 EAIGPSTIRDLAVAGPEMQVKLlQSLGLKSTLIT-DGSTPINLF--NTAFGLLGMGPEGQPLGRRVasgPSPGEGISPQS 876
Cdd:cd08825 64 KAIASRIRGAVASVTFDDFHKN-SARIIRSAVFGdDEKGEVRDElrFPANNLVITNVDIQSVEPVD---QRTRDSLQKSV 139
|
90
....*....|..
gi 21542417 877 AQAPQAPGDNHV 888
Cdd:cd08825 140 QLAIEITTNSQE 151
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
653-784 |
1.41e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 42.62 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 653 ALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEA 732
Cdd:COG1196 442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 21542417 733 arIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKA 784
Cdd:COG1196 522 --LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA 571
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
647-791 |
5.44e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 40.69 E-value: 5.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 647 DQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEA 726
Cdd:COG1196 280 ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21542417 727 ESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791
Cdd:COG1196 360 LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
644-791 |
5.92e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 40.31 E-value: 5.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 644 EPVDQRTRDALQRSVQLAIEITtnSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAK 723
Cdd:COG1196 305 ARLEERRRELEERLEELEEELA--ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21542417 724 AEAESRaeaarIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791
Cdd:COG1196 383 ELAEEL-----LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445
|
|
|