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Conserved domains on  [gi|21542417|sp|Q14764|]
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RecName: Full=Major vault protein; Short=MVP; AltName: Full=Lung resistance-related protein

Protein Classification

major vault protein( domain architecture ID 1009019)

major vault protein (MVP) is required for normal vault structure

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00491 super family cl36570
major vault protein; Provisional
4-850 0e+00

major vault protein; Provisional


The actual alignment was detected with superfamily member PTZ00491:

Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 1181.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417    4 EEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRL 83
Cdd:PTZ00491   3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417   84 RHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEII 163
Cdd:PTZ00491  83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  164 QATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRD-FRGVS 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDvYGGIA 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  243 RRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLE-QGIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEgDGIQ 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  322 DVYVLSEQQGLLLRAlqpLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRA---LETFTDEDGVEREPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  402 IGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLAD-------RGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAQPRSSMAYsersgqaSGKVPYEENPGFESHRDKHRVVTYKVPHNAAVQLYDYK 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  475 EKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKD 554
Cdd:PTZ00491 480 TKKSRVVFGPDLVMLEPDEEFTVLSLSGGKPKVPNQIHSLHLFLGPDFMTDVIHVETSDHARLALQLSYNWYFDV-TDGN 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  555 PQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGF--ETSEakgpdgmalprPRDQAVFPQNG 632
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFGSndETGE-----------VRDSLRFPANN 627
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  633 LVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAL 712
Cdd:PTZ00491 628 LVITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAE 707
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  713 SMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEV 792
Cdd:PTZ00491 708 SAAVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEA 787
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 21542417  793 KKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG 850
Cdd:PTZ00491 788 TKFERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
 
Name Accession Description Interval E-value
PTZ00491 PTZ00491
major vault protein; Provisional
4-850 0e+00

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 1181.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417    4 EEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRL 83
Cdd:PTZ00491   3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417   84 RHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEII 163
Cdd:PTZ00491  83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  164 QATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRD-FRGVS 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDvYGGIA 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  243 RRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLE-QGIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEgDGIQ 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  322 DVYVLSEQQGLLLRAlqpLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRA---LETFTDEDGVEREPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  402 IGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLAD-------RGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAQPRSSMAYsersgqaSGKVPYEENPGFESHRDKHRVVTYKVPHNAAVQLYDYK 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  475 EKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKD 554
Cdd:PTZ00491 480 TKKSRVVFGPDLVMLEPDEEFTVLSLSGGKPKVPNQIHSLHLFLGPDFMTDVIHVETSDHARLALQLSYNWYFDV-TDGN 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  555 PQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGF--ETSEakgpdgmalprPRDQAVFPQNG 632
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFGSndETGE-----------VRDSLRFPANN 627
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  633 LVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAL 712
Cdd:PTZ00491 628 LVITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAE 707
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  713 SMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEV 792
Cdd:PTZ00491 708 SAAVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEA 787
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 21542417  793 KKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG 850
Cdd:PTZ00491 788 TKFERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
MVP_shoulder cd08825
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ...
509-670 2.14e-85

Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.


Pssm-ID: 259807  Cd Length: 151  Bit Score: 269.48  E-value: 2.14e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 509 HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKdPQETAKLFSVPDFVGDACKAIASRVRGAVASVTF 588
Cdd:cd08825   1 NQIKALCLLLGPDFMTDIITVETADHARLQLQLAYNWHFDVDDKK-PEEAAKLFSVPDFIGDACKAIASRIRGAVASVTF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 589 DDFHKNSARIIRTAVFGFetsEAKGPDgmalprpRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNS 668
Cdd:cd08825  80 DDFHKNSARIIRSAVFGD---DEKGEV-------RDELRFPANNLVITNVDIQSVEPVDQRTRDSLQKSVQLAIEITTNS 149

                ..
gi 21542417 669 QE 670
Cdd:cd08825 150 QE 151
MVP_shoulder pfam11978
Shoulder domain; This domain is found in the Major Vault Protein and has been called the ...
519-647 6.32e-61

Shoulder domain; This domain is found in the Major Vault Protein and has been called the shoulder domain. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.


Pssm-ID: 463418  Cd Length: 118  Bit Score: 202.09  E-value: 6.32e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417   519 GPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARI 598
Cdd:pfam11978   1 GPDFMTDIITVETADHARLQLQLSYNWHFDV-DDGDPEDAAKLFSVPDFVGDACKAIASRIRGAVASVTFDDFHKNSAKI 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 21542417   599 IRTAVFGFetsEAKGpdgmalpRPRDQAVFPQNGLVVSSVDVQSVEPVD 647
Cdd:pfam11978  80 IRRAVFGV---DENG-------EVRDSLLFPENNLVITSVDVQSVEPVD 118
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
653-784 1.41e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 653 ALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEA 732
Cdd:COG1196 442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21542417 733 arIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKA 784
Cdd:COG1196 522 --LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA 571
 
Name Accession Description Interval E-value
PTZ00491 PTZ00491
major vault protein; Provisional
4-850 0e+00

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 1181.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417    4 EEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRL 83
Cdd:PTZ00491   3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417   84 RHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEII 163
Cdd:PTZ00491  83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  164 QATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRD-FRGVS 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDvYGGIA 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  243 RRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLE-QGIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEgDGIQ 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  322 DVYVLSEQQGLLLRAlqpLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRA---LETFTDEDGVEREPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  402 IGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLAD-------RGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAQPRSSMAYsersgqaSGKVPYEENPGFESHRDKHRVVTYKVPHNAAVQLYDYK 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  475 EKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKD 554
Cdd:PTZ00491 480 TKKSRVVFGPDLVMLEPDEEFTVLSLSGGKPKVPNQIHSLHLFLGPDFMTDVIHVETSDHARLALQLSYNWYFDV-TDGN 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  555 PQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGF--ETSEakgpdgmalprPRDQAVFPQNG 632
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFGSndETGE-----------VRDSLRFPANN 627
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  633 LVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAL 712
Cdd:PTZ00491 628 LVITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAE 707
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417  713 SMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEV 792
Cdd:PTZ00491 708 SAAVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEA 787
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 21542417  793 KKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG 850
Cdd:PTZ00491 788 TKFERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
MVP_shoulder cd08825
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ...
509-670 2.14e-85

Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.


Pssm-ID: 259807  Cd Length: 151  Bit Score: 269.48  E-value: 2.14e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 509 HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKdPQETAKLFSVPDFVGDACKAIASRVRGAVASVTF 588
Cdd:cd08825   1 NQIKALCLLLGPDFMTDIITVETADHARLQLQLAYNWHFDVDDKK-PEEAAKLFSVPDFIGDACKAIASRIRGAVASVTF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 589 DDFHKNSARIIRTAVFGFetsEAKGPDgmalprpRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNS 668
Cdd:cd08825  80 DDFHKNSARIIRSAVFGD---DEKGEV-------RDELRFPANNLVITNVDIQSVEPVDQRTRDSLQKSVQLAIEITTNS 149

                ..
gi 21542417 669 QE 670
Cdd:cd08825 150 QE 151
MVP_shoulder pfam11978
Shoulder domain; This domain is found in the Major Vault Protein and has been called the ...
519-647 6.32e-61

Shoulder domain; This domain is found in the Major Vault Protein and has been called the shoulder domain. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.


Pssm-ID: 463418  Cd Length: 118  Bit Score: 202.09  E-value: 6.32e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417   519 GPDFFTDVITIETADHARLQLQLAYNWHFEVnDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARI 598
Cdd:pfam11978   1 GPDFMTDIITVETADHARLQLQLSYNWHFDV-DDGDPEDAAKLFSVPDFVGDACKAIASRIRGAVASVTFDDFHKNSAKI 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 21542417   599 IRTAVFGFetsEAKGpdgmalpRPRDQAVFPQNGLVVSSVDVQSVEPVD 647
Cdd:pfam11978  80 IRRAVFGV---DENG-------EVRDSLLFPENNLVITSVDVQSVEPVD 118
Vault_2 pfam17794
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the ...
50-109 9.36e-30

Major Vault Protein repeat domain; This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to pfam01505.


Pssm-ID: 407666 [Multi-domain]  Cd Length: 60  Bit Score: 112.18  E-value: 9.36e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417    50 MVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDI 109
Cdd:pfam17794   1 MITLPPRSYCVVANPVSRDGKGSPVLDQHGQVRLVHGDKEIRLAQDPFPLYPGEKLEGDI 60
Vault_3 pfam17795
Major Vault Protein Repeat domain; This domain is found in the Major Vault Protein.
457-518 2.00e-28

Major Vault Protein Repeat domain; This domain is found in the Major Vault Protein.


Pssm-ID: 407667  Cd Length: 62  Bit Score: 108.31  E-value: 2.00e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21542417   457 VVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLL 518
Cdd:pfam17795   1 VVTFRVPHNALVQLYDYKTKKSRVVFGPLLVSLEPHEHFTVLSLSGGQPKEPNAIHSLCLYL 62
Vault_4 pfam17796
Major Vault Protein repeat domain;
379-439 7.10e-24

Major Vault Protein repeat domain;


Pssm-ID: 407668 [Multi-domain]  Cd Length: 61  Bit Score: 95.37  E-value: 7.10e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21542417   379 AIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGE 439
Cdd:pfam17796   1 AIPLDENEGIYVRNIRTGEVRVVTGQTYMLTESEELWEKELPPGVEVLLAEARDPLAGRDS 61
Vault pfam01505
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ...
113-153 1.09e-15

Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.


Pssm-ID: 460235 [Multi-domain]  Cd Length: 41  Bit Score: 71.31  E-value: 1.09e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21542417   113 QVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIP 153
Cdd:pfam01505   1 YVLSENEALRLRALEDFTDRDGVERKAGEEWLVRGPGTYIP 41
Vault pfam01505
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ...
166-206 2.62e-14

Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.


Pssm-ID: 460235 [Multi-domain]  Cd Length: 41  Bit Score: 67.46  E-value: 2.62e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21542417   166 TIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLP 206
Cdd:pfam01505   1 YVLSENEALRLRALEDFTDRDGVERKAGEEWLVRGPGTYIP 41
Vault pfam01505
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ...
324-367 7.86e-12

Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.


Pssm-ID: 460235 [Multi-domain]  Cd Length: 41  Bit Score: 60.52  E-value: 7.86e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 21542417   324 YVLSEQQGLLLRALqplEEGEDEEKVSHQAGDHWLIRGPLEYVP 367
Cdd:pfam01505   1 YVLSENEALRLRAL---EDFTDRDGVERKAGEEWLVRGPGTYIP 41
Vault pfam01505
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ...
220-261 1.10e-11

Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.


Pssm-ID: 460235 [Multi-domain]  Cd Length: 41  Bit Score: 60.14  E-value: 1.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21542417   220 ILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTvqDTEAHVP 261
Cdd:pfam01505   2 VLSENEALRLRALEDFTDRDGVERKAGEEWLVR--GPGTYIP 41
SPFH_like cd02106
core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model ...
525-619 3.52e-09

core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons, and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, and in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259797 [Multi-domain]  Cd Length: 110  Bit Score: 55.06  E-value: 3.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 525 DVITIETADHARLQLQLAYNWHFEVNDRKDpqETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNsARIIRTAVF 604
Cdd:cd02106   8 RVEPVGTADGVPVAVDLVVQFRITDYNALP--AFYLVDFVKDIKADIRRKIADVLRAAIGRMTLDQIISG-RDEIAKAVK 84
                        90
                ....*....|....*
gi 21542417 605 GFETsEAKGPDGMAL 619
Cdd:cd02106  85 EDLE-EDLENFGVVI 98
Vault_2 pfam17794
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the ...
273-320 6.39e-09

Major Vault Protein repeat domain; This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to pfam01505.


Pssm-ID: 407666 [Multi-domain]  Cd Length: 60  Bit Score: 52.86  E-value: 6.39e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417   273 ITTLGPHNYCVILDPVGPDGK-----NQLGQKRVVKGEKS-------FFLQPGEQLEQGI 320
Cdd:pfam17794   1 MITLPPRSYCVVANPVSRDGKgspvlDQHGQVRLVHGDKEirlaqdpFPLYPGEKLEGDI 60
MVP_shoulder cd08825
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ...
800-888 4.68e-08

Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.


Pssm-ID: 259807  Cd Length: 151  Bit Score: 53.00  E-value: 4.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 800 EAIGPSTIRDLAVAGPEMQVKLlQSLGLKSTLIT-DGSTPINLF--NTAFGLLGMGPEGQPLGRRVasgPSPGEGISPQS 876
Cdd:cd08825  64 KAIASRIRGAVASVTFDDFHKN-SARIIRSAVFGdDEKGEVRDElrFPANNLVITNVDIQSVEPVD---QRTRDSLQKSV 139
                        90
                ....*....|..
gi 21542417 877 AQAPQAPGDNHV 888
Cdd:cd08825 140 QLAIEITTNSQE 151
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
653-784 1.41e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 653 ALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEA 732
Cdd:COG1196 442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21542417 733 arIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKA 784
Cdd:COG1196 522 --LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA 571
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
647-791 5.44e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 5.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 647 DQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEA 726
Cdd:COG1196 280 ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21542417 727 ESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791
Cdd:COG1196 360 LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
644-791 5.92e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 5.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542417 644 EPVDQRTRDALQRSVQLAIEITtnSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAK 723
Cdd:COG1196 305 ARLEERRRELEERLEELEEELA--ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21542417 724 AEAESRaeaarIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791
Cdd:COG1196 383 ELAEEL-----LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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