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Conserved domains on  [gi|341941763|sp|Q14B62|]
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RecName: Full=Patched domain-containing protein 1

Protein Classification

patched/dispatched family protein( domain architecture ID 1904021)

patched/dispatched family protein may be involved in hedgehog (Hh) signaling, similar to Drosophila melanogaster proteins patched and dispatched, that acts as a receptor for Hh and a regulator of Hh trafficking, respectively

Gene Ontology:  GO:0007165|GO:0016020
PubMed:  36932157|21778405

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Patched super family cl44384
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
105-851 2.09e-79

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


The actual alignment was detected with superfamily member pfam02460:

Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 273.85  E-value: 2.09e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  105 NMLDQHHTDLILKL-HTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDivHVLEELknARATNRTNFAITYPITHLKdG 183
Cdd:pfam02460  57 NILDISYLNDIYQLnDYISTNVEIQVDGIIISFKDLCSRYCDLNCPVNK--HYNGML--LSRRHNTRIDITYPIMPVL-G 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  184 RAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKlfQKSNSK-VKIYPYTSSSLREDFQ 262
Cdd:pfam02460 132 TPIYLGPHFGGVDFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQLLH--NKYASEhIQFTIFHDQILNDELV 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  263 KTSRVSERYLVTSLILVVTMAILCC-----SMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVML 337
Cdd:pfam02460 210 RNALTLTPFFVIGFFLLLTFSIIVSvtlssYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVL 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  338 GHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGAspFTNIEAARIFCCNSCIAILFNYLYV 417
Cdd:pfam02460 290 AIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGT--YTPTPAIQLFCAYTAVAIFFDFIYQ 367
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  418 LSFYGSSLVFTGYIENNYQHSIFcrkVPKPDVLQEkpawyrfllTARFSEETAEGEEANTYESHllvcFLKRYYCDWITN 497
Cdd:pfam02460 368 ITFFAAIMAICAKPEAEGRHCLF---VWATSSPQR---------IDSEGSEPDKSHNIEQLKSR----FFLDIYCPFLLN 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  498 TYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEY-TTAHQKYFNNYSPVI-------GFYIYESIEYWNS 569
Cdd:pfam02460 432 PSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYlSLREKHFWPEGLQIQvavnnppNLTIPESRDRMNE 511
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  570 SVQE-DVLEYTKGFVRIS-WFESYLNYLRKLNV-STDLPKKNFTDMLRNSFLKTPQFSHFQEDIifskKYNDEVDVVASR 646
Cdd:pfam02460 512 MVDEfENTPYSLGPNSTLfWLREYENFLSTLNMeEEEDEEKEWSYGNLPSFLKAPGNSHWAGDL----VWDDNTTMVTKF 587
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  647 MFLVAKTMETNREELYDLLETLRrlSVTSKVKF---IVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLI 723
Cdd:pfam02460 588 RFTLAGKGLSTWNDRTRALQEWR--SIADQYPEfnvTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPC 665
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  724 NVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYL 803
Cdd:pfam02460 666 VFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGL 745
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*...
gi 341941763  804 CYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPP 851
Cdd:pfam02460 746 STILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLFVT 793
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
105-851 2.09e-79

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 273.85  E-value: 2.09e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  105 NMLDQHHTDLILKL-HTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDivHVLEELknARATNRTNFAITYPITHLKdG 183
Cdd:pfam02460  57 NILDISYLNDIYQLnDYISTNVEIQVDGIIISFKDLCSRYCDLNCPVNK--HYNGML--LSRRHNTRIDITYPIMPVL-G 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  184 RAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKlfQKSNSK-VKIYPYTSSSLREDFQ 262
Cdd:pfam02460 132 TPIYLGPHFGGVDFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQLLH--NKYASEhIQFTIFHDQILNDELV 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  263 KTSRVSERYLVTSLILVVTMAILCC-----SMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVML 337
Cdd:pfam02460 210 RNALTLTPFFVIGFFLLLTFSIIVSvtlssYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVL 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  338 GHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGAspFTNIEAARIFCCNSCIAILFNYLYV 417
Cdd:pfam02460 290 AIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGT--YTPTPAIQLFCAYTAVAIFFDFIYQ 367
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  418 LSFYGSSLVFTGYIENNYQHSIFcrkVPKPDVLQEkpawyrfllTARFSEETAEGEEANTYESHllvcFLKRYYCDWITN 497
Cdd:pfam02460 368 ITFFAAIMAICAKPEAEGRHCLF---VWATSSPQR---------IDSEGSEPDKSHNIEQLKSR----FFLDIYCPFLLN 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  498 TYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEY-TTAHQKYFNNYSPVI-------GFYIYESIEYWNS 569
Cdd:pfam02460 432 PSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYlSLREKHFWPEGLQIQvavnnppNLTIPESRDRMNE 511
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  570 SVQE-DVLEYTKGFVRIS-WFESYLNYLRKLNV-STDLPKKNFTDMLRNSFLKTPQFSHFQEDIifskKYNDEVDVVASR 646
Cdd:pfam02460 512 MVDEfENTPYSLGPNSTLfWLREYENFLSTLNMeEEEDEEKEWSYGNLPSFLKAPGNSHWAGDL----VWDDNTTMVTKF 587
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  647 MFLVAKTMETNREELYDLLETLRrlSVTSKVKF---IVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLI 723
Cdd:pfam02460 588 RFTLAGKGLSTWNDRTRALQEWR--SIADQYPEfnvTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPC 665
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  724 NVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYL 803
Cdd:pfam02460 666 VFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGL 745
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*...
gi 341941763  804 CYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPP 851
Cdd:pfam02460 746 STILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLFVT 793
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
192-585 3.99e-19

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 93.02  E-value: 3.99e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   192 LGGVTVHSKDRVKSAEAIQLT----------------YYLQSINSLNDMVA---ERWESSFCDTVKLFQKSNSKVKIYPY 252
Cdd:TIGR00918  303 VGGTKRNRSGKLLSAQALQSMfqlmtpkqmyehfkgyYKVHHIGWNEEKAAavlEAWQRNFSEEVQQSLPKNSSQKILVF 382
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   253 TSSSLREDFQKTSRVSERYLVTSLILVVTMAilCCSM--QDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STF 329
Cdd:TIGR00918  383 SSTTLDDILKKFSDVSAIRIVSGYLLMLAYA--CLTMlrWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNaATT 460
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   330 LGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGAspFTNIEAARIFCCNSCIA 409
Cdd:TIGR00918  461 QVLPFLALGVGVDDVFLLAHAFSETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAA--LIPIPALRAFSLQAAIV 538
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   410 ILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVP--KPDVLQEKPAWYRF---------------------------- 459
Cdd:TIGR00918  539 VVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSpcSARVIQIEPQAYADgsappvysshmqstvqlrteydpgtqhy 618
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   460 -----------------LLTARFS------------EETAEGEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLI 510
Cdd:TIGR00918  619 yttneprshlsvqpsdpLSCQSPDiagstrdllsqfEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLA 698
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 341941763   511 YISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSpvigFYIYESIEYWNSSVQEDVLEYTKGFVRI 585
Cdd:TIGR00918  699 LLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYN----MYAVTQGNFDYPTQQQLLYDLHQSFSSV 769
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
14-460 4.05e-03

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 41.00  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  14 FSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLaPQHSLAKIERNLVNSLFpvnrskhrlysdlqTPGRY 93
Cdd:COG1033    4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLL-PEDDPSVQAYDEFEEEF--------------GGDDT 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  94 GRVIVTSyqKANMLDQHHTDLILKLHTAVTKIqvprPGFNYTfahICVLNNDKTCIVDDIVHVLEELKNARATNRTNFAi 173
Cdd:COG1033   69 VVVAVEG--KDDIFTPETLEALRELTEELEEI----PGVDSV---TSLTNVRATEGTEDGLTVEPLIPDELPASPEELA- 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763 174 typitHLKdgRAVYNGHQLGGVTVhSKDrvKSAEAIQLTYYLQSINSLNDM--VAERWEssfcDTVKLFQKSNSKVKIY- 250
Cdd:COG1033  139 -----ELR--EKVLSSPLYVGRLV-SPD--GKATLIVVTLDPDPLSSDLDRkeVVAEIR----AIIAKYEDPGVEVYLTg 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763 251 -PYtsssLREDFQK-TSRVSERYLVTSLILVVTMAILCCsmqdcvRSkPWLGLLGLVTISLATLTAAGIINLTGGKYNST 328
Cdd:COG1033  205 fPV----LRGDIAEaIQSDLAIFFPLALLLILLLLFLFF------RS-LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPL 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763 329 FLGVPFVMLGHGL-YGTFeMLSSWRK-TREDQHVKERTAEVYADSMLSF---SLTTAmylvtFGIGASPFTNIEAARIFC 403
Cdd:COG1033  274 TILVPPLLLAIGIdYGIH-LLNRYREeRRKGLDKREALREALRKLGPPVlltSLTTA-----IGFLSLLFSDIPPIRDFG 347
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 341941763 404 CNSCIAILFNYLYVLSFYGSSLVFTGyiennyqhsifcRKVPKPDVLQEKPAWYRFL 460
Cdd:COG1033  348 IVAAIGVLLAFLTSLTLLPALLSLLP------------RPKPKTRRLKKPPELGRLL 392
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
105-851 2.09e-79

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 273.85  E-value: 2.09e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  105 NMLDQHHTDLILKL-HTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDivHVLEELknARATNRTNFAITYPITHLKdG 183
Cdd:pfam02460  57 NILDISYLNDIYQLnDYISTNVEIQVDGIIISFKDLCSRYCDLNCPVNK--HYNGML--LSRRHNTRIDITYPIMPVL-G 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  184 RAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKlfQKSNSK-VKIYPYTSSSLREDFQ 262
Cdd:pfam02460 132 TPIYLGPHFGGVDFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQLLH--NKYASEhIQFTIFHDQILNDELV 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  263 KTSRVSERYLVTSLILVVTMAILCC-----SMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVML 337
Cdd:pfam02460 210 RNALTLTPFFVIGFFLLLTFSIIVSvtlssYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVL 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  338 GHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGAspFTNIEAARIFCCNSCIAILFNYLYV 417
Cdd:pfam02460 290 AIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGT--YTPTPAIQLFCAYTAVAIFFDFIYQ 367
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  418 LSFYGSSLVFTGYIENNYQHSIFcrkVPKPDVLQEkpawyrfllTARFSEETAEGEEANTYESHllvcFLKRYYCDWITN 497
Cdd:pfam02460 368 ITFFAAIMAICAKPEAEGRHCLF---VWATSSPQR---------IDSEGSEPDKSHNIEQLKSR----FFLDIYCPFLLN 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  498 TYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEY-TTAHQKYFNNYSPVI-------GFYIYESIEYWNS 569
Cdd:pfam02460 432 PSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYlSLREKHFWPEGLQIQvavnnppNLTIPESRDRMNE 511
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  570 SVQE-DVLEYTKGFVRIS-WFESYLNYLRKLNV-STDLPKKNFTDMLRNSFLKTPQFSHFQEDIifskKYNDEVDVVASR 646
Cdd:pfam02460 512 MVDEfENTPYSLGPNSTLfWLREYENFLSTLNMeEEEDEEKEWSYGNLPSFLKAPGNSHWAGDL----VWDDNTTMVTKF 587
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  647 MFLVAKTMETNREELYDLLETLRrlSVTSKVKF---IVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLI 723
Cdd:pfam02460 588 RFTLAGKGLSTWNDRTRALQEWR--SIADQYPEfnvTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPC 665
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  724 NVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYL 803
Cdd:pfam02460 666 VFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGL 745
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*...
gi 341941763  804 CYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPP 851
Cdd:pfam02460 746 STILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLFVT 793
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
192-585 3.99e-19

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 93.02  E-value: 3.99e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   192 LGGVTVHSKDRVKSAEAIQLT----------------YYLQSINSLNDMVA---ERWESSFCDTVKLFQKSNSKVKIYPY 252
Cdd:TIGR00918  303 VGGTKRNRSGKLLSAQALQSMfqlmtpkqmyehfkgyYKVHHIGWNEEKAAavlEAWQRNFSEEVQQSLPKNSSQKILVF 382
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   253 TSSSLREDFQKTSRVSERYLVTSLILVVTMAilCCSM--QDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STF 329
Cdd:TIGR00918  383 SSTTLDDILKKFSDVSAIRIVSGYLLMLAYA--CLTMlrWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNaATT 460
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   330 LGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGAspFTNIEAARIFCCNSCIA 409
Cdd:TIGR00918  461 QVLPFLALGVGVDDVFLLAHAFSETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAA--LIPIPALRAFSLQAAIV 538
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   410 ILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVP--KPDVLQEKPAWYRF---------------------------- 459
Cdd:TIGR00918  539 VVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSpcSARVIQIEPQAYADgsappvysshmqstvqlrteydpgtqhy 618
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   460 -----------------LLTARFS------------EETAEGEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLI 510
Cdd:TIGR00918  619 yttneprshlsvqpsdpLSCQSPDiagstrdllsqfEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLA 698
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 341941763   511 YISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSpvigFYIYESIEYWNSSVQEDVLEYTKGFVRI 585
Cdd:TIGR00918  699 LLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYN----MYAVTQGNFDYPTQQQLLYDLHQSFSSV 769
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
10-849 2.12e-17

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 87.66  E-value: 2.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763    10 LRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIERNLVNSLF-PVNRSKHRLYSDLQ 88
Cdd:TIGR00917  309 LARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFgPFYRIEQLIIATVQ 388
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763    89 TpgrygrvivTSYQKA-NMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAHICVLNNDK-TCIVDDIVHVLEelKNARAT 166
Cdd:TIGR00917  389 T---------SSHEKApEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPyNCFIYSTCKKLQ--NMYSKL 457
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   167 NRTNFAITYPITHLKD---------------GRAVYNGHQLGGvtvHSKDRVKSAEAIQLTYYLQSINSLNDMV--AERW 229
Cdd:TIGR00917  458 KPENYDDYGGVDYVKYcfehftspesclsafGGPVDPTTVLGG---FSGNNFSEASAFVVTFPVNNFVNKTNKTekAVAW 534
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   230 ESSFCDTVKLFQKSNSKVKIYPYTSSSLREDFQKTSR-----VSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGL 304
Cdd:TIGR00917  535 EKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTadvitIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGLSGI 614
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   305 VTISLATLTAAGIINLTGGKYNSTFLGV-PFVMLGHG------LYGTFEMLSSWRKTREDQHVKERTAE-----VYADSM 372
Cdd:TIGR00917  615 LIVMLSVLGSVGVFSAVGLKSTLIIMEViPFLVLAVGvdnifiLVFFYFYLEYFYRQVGVDNEQELTLErrlsrALMEVG 694
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   373 LSFSLTTAMYLVTFGIGAspFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIF-CRKVPKPDVlq 451
Cdd:TIGR00917  695 PSITLASLSEILAFALGA--LIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFpCIKTSKSSI-- 770
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   452 ekpawyrflltarfSEETAEGEEANTyeshLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNI 531
Cdd:TIGR00917  771 --------------SAEKGSGQRKAG----LLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIV 832
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   532 VATATQTIEYTTAHQKYFNNYSPVI----GFYIYESIEYWN----------SSVQEDVLEYTK-GFVRISWFESYLNYLR 596
Cdd:TIGR00917  833 LPQDSYLQIYFASLTPLLEVGPPFYivikGDYNYTDFESQNklctmggcdkDSIVNVFNNLSYiAKPASSWLDDYLVWLS 912
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   597 KlnVSTDLPKKNFTDM--------------LRNSFLKTPQFSHFQEDIIF--------------SKKYNDEVD------- 641
Cdd:TIGR00917  913 P--QASCCCRKFTNGTfcngpdpqcfrcadLSSDAQGRPSTTQFKEKLPWflnalpsadcakggHAAYSSAVDlqgyati 990
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   642 VVASRmFLVAKTMETNREELYDLLETLRRLS--VTSKVKFIVFNPSFVYM--DRYASSLGAPLHNSCISALFLLFFSAFL 717
Cdd:TIGR00917  991 IQASS-FRTYHTPLNTQVDFINAMRAAQEFAakVSRSSKMEVYPYSVFYVffEQYLTIWKTAIINLSIALGAIFIVCLFL 1069
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763   718 VA-DSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGV 796
Cdd:TIGR00917 1070 LQlNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGS 1149
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 341941763   797 AILQS-YLCYIVGLFPLAAVPSNL-TCTLFRCLFLIAFVTFFHCFAILPVILTFL 849
Cdd:TIGR00917 1150 SVFSGiTLTKLVGVVVLGFSRSEIfVVYYFRMYLALVLLGFLHGLVFLPVLLSVL 1204
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
292-442 1.82e-15

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 74.54  E-value: 1.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  292 CVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGV-PFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYAD 370
Cdd:pfam12349   1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEViPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 341941763  371 SMLSFSLTTAMYLVTFGIGAspFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCR 442
Cdd:pfam12349  81 VGPSITLTSLTEILAFLLGA--LTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACC 150
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
266-427 2.02e-05

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 48.31  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  266 RVSERYLVTSLILVVTM---AILCCSMQDC----VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLG 338
Cdd:TIGR00920  52 KFEEEYLSSDVIVMTITrciAVLYIYYQFCnlrqLGSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLNEALPFFLLL 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  339 HGLYGTFEMLSSWRKTREDQHVKERTAEVYAdsMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAILFNYLYVL 418
Cdd:TIGR00920 132 IDLSKASALAKFALSSNSQDEVRDNIARGMA--ILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFM 209
                         170
                  ....*....|.
gi 341941763  419 SFYGS--SLVF 427
Cdd:TIGR00920 210 TFFPAclSLVL 220
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
14-460 4.05e-03

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 41.00  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  14 FSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLaPQHSLAKIERNLVNSLFpvnrskhrlysdlqTPGRY 93
Cdd:COG1033    4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLL-PEDDPSVQAYDEFEEEF--------------GGDDT 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763  94 GRVIVTSyqKANMLDQHHTDLILKLHTAVTKIqvprPGFNYTfahICVLNNDKTCIVDDIVHVLEELKNARATNRTNFAi 173
Cdd:COG1033   69 VVVAVEG--KDDIFTPETLEALRELTEELEEI----PGVDSV---TSLTNVRATEGTEDGLTVEPLIPDELPASPEELA- 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763 174 typitHLKdgRAVYNGHQLGGVTVhSKDrvKSAEAIQLTYYLQSINSLNDM--VAERWEssfcDTVKLFQKSNSKVKIY- 250
Cdd:COG1033  139 -----ELR--EKVLSSPLYVGRLV-SPD--GKATLIVVTLDPDPLSSDLDRkeVVAEIR----AIIAKYEDPGVEVYLTg 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763 251 -PYtsssLREDFQK-TSRVSERYLVTSLILVVTMAILCCsmqdcvRSkPWLGLLGLVTISLATLTAAGIINLTGGKYNST 328
Cdd:COG1033  205 fPV----LRGDIAEaIQSDLAIFFPLALLLILLLLFLFF------RS-LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPL 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941763 329 FLGVPFVMLGHGL-YGTFeMLSSWRK-TREDQHVKERTAEVYADSMLSF---SLTTAmylvtFGIGASPFTNIEAARIFC 403
Cdd:COG1033  274 TILVPPLLLAIGIdYGIH-LLNRYREeRRKGLDKREALREALRKLGPPVlltSLTTA-----IGFLSLLFSDIPPIRDFG 347
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 341941763 404 CNSCIAILFNYLYVLSFYGSSLVFTGyiennyqhsifcRKVPKPDVLQEKPAWYRFL 460
Cdd:COG1033  348 IVAAIGVLLAFLTSLTLLPALLSLLP------------RPKPKTRRLKKPPELGRLL 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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