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Conserved domains on  [gi|121957962|sp|Q1LZD0|]
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RecName: Full=Adenosine receptor A2b

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
8-300 0e+00

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15069:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 294  Bit Score: 533.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLV 87
Cdd:cd15069    1 ATYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  88 LTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIAT-NCTEPGDAATNVSCC 166
Cdd:cd15069   81 LTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATnNSTNPADHGTNHSCC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 167 LIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCW 246
Cdd:cd15069  161 LISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCW 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 247 LPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15069  241 LPVHILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
 
Name Accession Description Interval E-value
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
8-300 0e+00

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 533.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLV 87
Cdd:cd15069    1 ATYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  88 LTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIAT-NCTEPGDAATNVSCC 166
Cdd:cd15069   81 LTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATnNSTNPADHGTNHSCC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 167 LIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCW 246
Cdd:cd15069  161 LISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCW 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 247 LPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15069  241 LPVHILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
24-289 1.37e-52

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 173.64  E-value: 1.37e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDF---HSCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPfgsALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  101 VDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGwndrkiATNCTEPGDaatNVSCCLIRCLFENVVPMSY 180
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLF------GWTLTVPEG---NVTVCFIDFPEDLSKPVSY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  181 MVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRtelmDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQP 260
Cdd:pfam00001 152 TLLISVLGFLL-PLLVILVCYTLIIRTLRKSASK----QKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLAL 226
                         250       260       270
                  ....*....|....*....|....*....|...
gi 121957962  261 TwakVKPKWAINTAIL----LSHANSAVNPIVY 289
Cdd:pfam00001 227 D---CELSRLLDKALSvtlwLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
21-296 7.89e-12

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 65.18  E-value: 7.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAaVGTSSALQTPTNYFLVSLAAADVavgLFAIPFAVTI--------SLGFCTdfhsCLFLACFVLVLTQSS 92
Cdd:PHA03087  54 GLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDL---LFVMTLPFQIyyyilfqwSFGEFA----CKIVSGLYYIGFYNS 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWNDRKiatnctepgdaatNVSCCLIRCLF 172
Cdd:PHA03087 126 MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISI-IETTPILFVYTTK-------------KDHETLICCMF 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYFNFFGCV---LPPLLIMLVIYVKIFLVACRQLQRTelmdhsrtvlqREIHAAKSLALIVGIFALCWLPV 249
Cdd:PHA03087 192 YNNKTMNWKLFINFEINIigmLIPLTILLYCYSKILITLKGINKSK-----------KNKKAIKLVLIIVILFVIFWLPF 260
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 121957962 250 H------TINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDF 296
Cdd:PHA03087 261 NvsvfvySLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFF 313
 
Name Accession Description Interval E-value
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
8-300 0e+00

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 533.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLV 87
Cdd:cd15069    1 ATYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  88 LTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIAT-NCTEPGDAATNVSCC 166
Cdd:cd15069   81 LTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATnNSTNPADHGTNHSCC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 167 LIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCW 246
Cdd:cd15069  161 LISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCW 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 247 LPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15069  241 LPVHILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
8-300 1.25e-144

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 409.34  E-value: 1.25e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLV 87
Cdd:cd14968    1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNFHGCLFMACLVLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  88 LTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNctepgdaatNVSCCL 167
Cdd:cd14968   81 LTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLES---------GCGEGG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 IRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTEL---MDHSRTVLQREIHAAKSLALIVGIFAL 244
Cdd:cd14968  152 IQCLFEEVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESllrSRRSRSTLQKEVKAAKSLAIILFLFAL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 245 CWLPVHTINCASLFQPTwaKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14968  232 CWLPLHIINCITLFCPE--CKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
9-300 1.43e-122

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 353.86  E-value: 1.43e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   9 VYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVL 88
Cdd:cd15068    2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  89 TQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdrkiatNCTEPGDAATNVSCC-- 166
Cdd:cd15068   82 TQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWN------NCGQPKEGKNHSQGCge 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 167 -LIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELM----DHSRTVLQREIHAAKSLALIVGI 241
Cdd:cd15068  156 gQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQplpgERARSTLQKEVHAAKSLAIIVGL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 242 FALCWLPVHTINCASLFQPTWAKvKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15068  236 FALCWLPLHIINCFTFFCPDCSH-APLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
8-300 2.02e-88

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 266.71  E-value: 2.02e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLV 87
Cdd:cd15071    1 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVLI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  88 LTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDrkiATNCTEPGDAATNVSCCL 167
Cdd:cd15071   81 LTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNN---LNAVERAWAANSSMGELV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 IRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHS--RTVLQREIHAAKSLALIVGIFALC 245
Cdd:cd15071  158 IKCQFETVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFYLIRKQLNKKVSSSSSdpQKYYGKELKIAKSLALILFLFALS 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 246 WLPVHTINCASLFQPTWAkvKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15071  238 WLPLHILNCITLFCPSCK--KPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
8-300 8.37e-80

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 244.69  E-value: 8.37e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLV 87
Cdd:cd15070    1 VTYISIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHFYSCLFMSCLLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  88 LTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdRKIATNctepgdaatNVSCCL 167
Cdd:cd15070   81 FTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWN-RKPSLE---------SVNTTP 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 IRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQL-QRTELMDHSRTVLQREIHAAKSLALIVGIFALCW 246
Cdd:cd15070  151 LQCQFTSVMRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLsQNATGFRETGAFYGREFKTAKSLALVLFLFAVCW 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 247 LPVHTINCASLFQPtwaKVkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15070  231 LPLSIINCVVYFNP---KV-PKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
21-300 5.26e-66

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 208.57  E-value: 5.26e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd14967   13 TVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPvlCRFWIALDVLCCTASILNLCA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDrkiatnctePGDAATNVSCClirCLFENVVpm 178
Cdd:cd14967   93 ISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRD---------ETQPSVVDCEC---EFTPNKI-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 sYMVYFNFFGCVLpPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd14967  159 -YVLVSSVISFFI-PLLIMIVLYARIFRVA-----------------RRELKAAKTLAIIVGAFLLCWLPFFIIYLVSAF 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAkvKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14967  220 CPPDC--VPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
21-293 5.68e-57

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 185.57  E-value: 5.68e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd00637   12 GLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDalCKLLGFLQSVSLLASILTLTA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIatnctepgdaatnVSCCLIRCLFENVVPM 178
Cdd:cd00637   92 ISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDY-------------GGYCCCCLCWPDLTLS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQ---LQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd00637  159 KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHrrrIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121957962 256 SLFQPTWAKVkPKWAINTAILLSHANSAVNPIVYAYRN 293
Cdd:cd00637  239 DVFGPDPSPL-PRILYFLALLLAYLNSAINPIIYAFFN 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
24-289 1.37e-52

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 173.64  E-value: 1.37e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDF---HSCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPfgsALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  101 VDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGwndrkiATNCTEPGDaatNVSCCLIRCLFENVVPMSY 180
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLF------GWTLTVPEG---NVTVCFIDFPEDLSKPVSY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  181 MVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRtelmDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQP 260
Cdd:pfam00001 152 TLLISVLGFLL-PLLVILVCYTLIIRTLRKSASK----QKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLAL 226
                         250       260       270
                  ....*....|....*....|....*....|...
gi 121957962  261 TwakVKPKWAINTAIL----LSHANSAVNPIVY 289
Cdd:pfam00001 227 D---CELSRLLDKALSvtlwLAYVNSCLNPIIY 256
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
22-300 1.06e-45

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 156.72  E-value: 1.06e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTI------SLG--FCTDFHSCLFLACfvlvltQSSI 93
Cdd:cd15051   15 VIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYelrgewPLGpvFCNIYISLDVMLC------TASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPF-LGWNDRKIATNCTEPGDAatnvscclirCLF 172
Cdd:cd15051   89 LNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhLGWNTPDGRVQNGDTPNQ----------CRF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYF-NFFGcvlpPLLIMLVIYVKIFLVACRQLQRTELMD-------HSRTVLQREIHAAKSLALIVGIFAL 244
Cdd:cd15051  159 ELNPPYVLLVAIgTFYL----PLLIMCGVYLRIFRIAREQAKRINALTpastansSKSAATAREHKATVTLAAVLGAFII 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121957962 245 CWLPVHTincasLFqpTWAKVKPkWAINTAIL-----LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15051  235 CWFPYFT-----YF--TYRGLCG-DNINETALsvvlwLGYANSALNPILYAFLNRDFRRAF 287
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
22-300 1.27e-42

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 149.52  E-value: 1.27e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG--FCTDFHSC-LFLACFVLVLTqSSIFSLLA 98
Cdd:cd15058   15 VVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTgkWQLGNFWCeLWTSVDVLCVT-ASIETLCV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAfgiGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIrclfenvvpM 178
Cdd:cd15058   94 IAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVS---ALVSFVPIMNQWWRANDPEANDCYQDPTCCDF---------R 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCV--LPPLLIMLVIYVKIFLVACRQLQ---RTELMDH---------------------SRTVLQREIHAA 232
Cdd:cd15058  162 TNMAYAIASSVVsfYIPLLIMIFVYARVFLIATRQLQlidKRRLRFQsecpapqttspegkrssgrrpSRLTVVKEHKAL 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 233 KSLALIVGIFALCWLPVHTINCASLFQPtwaKVKPKWAINTAILLSHANSAVNPIVYAyRNRDFRYTF 300
Cdd:cd15058  242 KTLGIIMGTFTLCWLPFFIANIINVFNR---NLPPGEVFLLLNWLGYINSGLNPIIYC-RSPEFRTAF 305
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
22-300 1.62e-42

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 147.80  E-value: 1.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--------GFCTdfhscLFLACFVLVLTqSSI 93
Cdd:cd15329   15 VVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELsgywpfgeILCD-----VWISFDVLLCT-ASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDrkiatNCTEPGDaatnvscCLIrclFE 173
Cdd:cd15329   89 LNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKN-----KVNDPGV-------CQV---SQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVVPMSYMVYFNFFGcvlpPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTIN 253
Cdd:cd15329  154 DFGYQIYATFGAFYI----PLIVMLVLYYKIYRAA-----------------KSERKAIKTLGIIMGAFTLCWLPFFILA 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 254 CA-SLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15329  213 LLrPFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
21-300 2.94e-42

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 147.12  E-value: 2.94e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL---------GFCTDFHSCLFLACfvlvltQS 91
Cdd:cd15067   13 TVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMtggywlfgrDWCDVWHSFDVLAS------TA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdrkiatnCTEPGDAATNVscclirCL 171
Cdd:cd15067   87 SILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWR-------AVDPGPSPPNQ------CL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 FenvvpMSYMVYFNFFGCV--LPPLLIMLVIYVKIFLVACRqlqrtelmdhsrtvlqrEIHAAKSLALIVGIFALCWLPV 249
Cdd:cd15067  154 F-----TDDSGYLIFSSCVsfYIPLVVMLFTYYRIYRAAAK-----------------EQKAAKTLGIVMGVFILCWLPF 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 250 HTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15067  212 FVTNILIGFCPSNCVSNPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
21-300 7.61e-42

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 147.11  E-value: 7.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLgfctdFHSCLFLA--CFVLV-----LTQSSI 93
Cdd:cd15065   13 AIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDL-----LGYWLFGEtfCNIWIsfdvmCSTASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTP-FLGWndrkiATNCTEPGDAATNVSCCLIRCLF 172
Cdd:cd15065   88 LNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPiHLGW-----HRLSQDEIKGLNHASNPKPSCAL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 EnvVPMSYMVYFNFFgCVLPPLLIMLVIYVKIFLVA------CRQLQRTELMDHSRTVLQREIH----------AAKSLA 236
Cdd:cd15065  163 D--LNPTYAVVSSLI-SFYIPCLVMLLIYSRLYLYArkhvvnIKSQKLPSESGSKFQVPSLSSKhnnqgvsdhkAAVTLG 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121957962 237 LIVGIFALCWLPVHTINCASLFQPTwakVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15065  240 IIMGVFLICWLPFFIINIIAAFCKT---CIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
21-300 2.03e-41

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 145.82  E-value: 2.03e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVtISLGFCTDFHS---CLFLACFVLVLTQSSIFSLL 97
Cdd:cd14993   14 ALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTL-LENVYRPWVFGevlCKAVPYLQGVSVSASVLTLV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNcTEPGDaaTNVSCCLIRcLFENVVP 177
Cdd:cd14993   93 AISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIML-PLLVVYELEEIIS-SEPGT--ITIYICTED-WPSPELR 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVyFNFFGCVLPPLLIMLVIYVKIFLVACR---QLQRTELMDHSRTVLQRE-IHAAKSLALIVGIFALCWLPVHTIN 253
Cdd:cd14993  168 KAYNV-ALFVVLYVLPLLIISVAYSLIGRRLWRrkpPGDRGSANSTSSRRILRSkKKVARMLIVVVVLFALSWLPYYVLS 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 254 CASLFQPTWAKVKPKWAINT---AILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14993  247 ILLDFGPLSSEESDENFLLIlpfAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
22-300 4.20e-41

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 144.18  E-value: 4.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT---ISLGFCTDFHSCLFLACFVLVLTqSSIFSLLA 98
Cdd:cd15063   15 VLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVnevLDVWIFGHTWCQIWLAVDVWMCT-ASILNLCA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKiATNCTEPGDAATNVSCCLIRclfenvvPM 178
Cdd:cd15063   94 ISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGK-DGIMDYSGSSSLPCTCELTN-------GR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYfNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTIncaSLF 258
Cdd:cd15063  166 GYVIY-SALGSFYIPMLVMLFFYFRIYRAA-----------------RMETKAAKTVAIIVGCFIFCWLPFFTV---YLV 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15063  225 RAFCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
21-300 1.17e-40

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 144.11  E-value: 1.17e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTP-TNYFLVSLAAADVAVGLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15057   14 TLLGNALVIAAVLRFRHLRSKvTNYFIVSLAVSDLLVAILVMPWaAVNEVAGYWPFGSFCDVWVSFDIMCSTASILNLCV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPF-LGWNDRKIATNCTEPgdAATNVSCCLIrcLFENVVP 177
Cdd:cd15057   94 ISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVqLGWHRADDTSEALAL--YADPCQCDSS--LNRTYAI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFfgcvlpPLLIMLVIYVKIFLVACRQLQR-----------TELMDHSRTVLQREIHAAKSLALIVGIFALCW 246
Cdd:cd15057  170 SSSLISFYI------PVAIMIVTYTRIYRIARRQIRRiaaleraaqesTNPDSSLRSSLRRETKALKTLSIIMGVFVCCW 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 247 LPVHTINCASLF---QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYrNRDFRYTF 300
Cdd:cd15057  244 LPFFILNCVLPFcdlRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYAF-NADFRKAF 299
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
22-300 3.08e-40

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 141.71  E-value: 3.08e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCL---FLACFVLVLTqSSIFSLLA 98
Cdd:cd15059   15 IVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWceiWLALDVLFCT-ASIVNLCA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRkiatncTEPGDAATNvscCLIRCLFENVVPM 178
Cdd:cd15059   94 ISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDE------QPWHGAEPQ---CELSDDPGYVLFS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFnffgcvlPPLLIMLVIYVKIFLVACRQLQRTELMdhsrtvlqreihaaksLALIVGIFALCWLPVHTinCASLF 258
Cdd:cd15059  165 SIGSFY-------IPLLIMIIVYARIYRAAKRKERRFTLV----------------LGVVMGAFVLCWLPFFF--TYPLV 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15059  220 VVCKTCGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
22-300 9.92e-40

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 141.15  E-value: 9.92e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15055   15 VLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDtfCKLHSSLDYILTSASIFNLVLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkiaTNCTEPGDAATNVscclirCLFENVVPMS 179
Cdd:cd15055   95 AIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLY--------DNLNQPGLIRYNS------CYGECVVVVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVY-FNFFGCVLPPLLIMLVIYVKIFLVACRQ--------LQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVH 250
Cdd:cd15055  161 FIWGvVDLVLTFILPCTVMIVLYMRIFVVARSQarairshtAQVSLEGSSKKVSKKSERKAAKTLGIVVGVFLLCWLPYY 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 251 tinCASLFQPTWAkvKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15055  241 ---IVSLVDPYIS--TPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
22-300 1.93e-38

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 137.76  E-value: 1.93e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15314   15 VCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDlfCKIHSSFDITLCTASILNLCFI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLA--FGIGLTpFLGWNDRKIATNCTEpgdaatnvscCLIRCLFENVVP 177
Cdd:cd15314   95 SIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSalVGFGII-FLELNIKGIYYNHVA----------CEGGCLVFFSKV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCvlpPLLIMLVIYVKIFLVACRQLQ--RTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCa 255
Cdd:cd15314  164 SSVVGSVFSFYI---PAVIMLCIYLKIFLVAQRQARsiQSARTKSGASSSKMERKATKTLAIVMGVFLLCWTPFFLCNI- 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 256 slFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15314  240 --IDPFINYSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
22-297 1.19e-37

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 135.58  E-value: 1.19e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQ-TPTNYFLVSLAAADVAVGLFaIPFAVT---ISLGFCTDFHSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15104   14 ITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLA-IPGLATdelLSDGENTQKVLCLLRMCFVITSCAASVLSLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndRKIATNCTEPGdaatnvsccliRCLFENVVP 177
Cdd:cd15104   93 AIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLI----SPQFQQTSYKG-----------KCSFFAAFH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFnFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSrtvLQREIH---------AAKSLALIVGIFALCWLP 248
Cdd:cd15104  158 PRVLLVL-SCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHA---LARQIHprrtlsdfkAARTVAVLIGCFLLSWLP 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 249 VHTincASLFQPTWAKVKP-KWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15104  234 FQI---TGLVQALCDECKLyDVLEDYLWLLGLCNSLLNPWIYAFWQKEVR 280
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
22-300 3.45e-37

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 135.03  E-value: 3.45e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSC---LFLACFVLVLTqSSIFSLLA 98
Cdd:cd15959   15 VGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTvceLWTSVDVLCVT-ASIETLCA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLG--WNDrkiaTNCTEPGDAATNVSCClirclfENVV 176
Cdd:cd15959   94 IAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqwWRD----GADEEAQRCYDNPRCC------DFVT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQ--------------------RTELMDHSRTVLQREIHAAKSLA 236
Cdd:cd15959  164 NMPYAIVSSTVSFYV-PLLVMIFVYVRVFVVATRQVRlirkdkvrfppeesppaesrPACGRRPSRLLAIKEHKALKTLG 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121957962 237 LIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINtaiLLSHANSAVNPIVYAyRNRDFRYTF 300
Cdd:cd15959  243 IIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFLN---WLGYANSAFNPIIYC-RSPDFRSAF 302
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
21-300 9.73e-37

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 132.45  E-value: 9.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG--------FCTdfhscLFLACFVLVLTqSS 92
Cdd:cd15064   14 TILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTgrwilgqvLCD-----IWISLDVTCCT-AS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATnctepgdaatnVSCCLIRclf 172
Cdd:cd15064   88 ILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSED-----------PSECLIS--- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVvpmSYMVYfNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTI 252
Cdd:cd15064  154 QDI---GYTIF-STFGAFYIPLLLMLILYWKIYRAA-----------------ARERKAAKTLGIILGAFIVCWLPFFLV 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 253 NCASLFQPTwAKVKPKWAiNTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15064  213 ALIVPLCSH-CWIPLALK-SFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
22-300 1.88e-36

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 133.10  E-value: 1.88e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15958   15 VAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSffCELWTSVDVLCVTASIETLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFL--GWNDR-KIATNCTEpgdaatNVSCClirclfENVV 176
Cdd:cd15958   95 AIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMmhWWRDEdDQALKCYE------DPGCC------DFVT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRTELMDH-----------------SRTVLQREIHAAKSLALIV 239
Cdd:cd15958  163 NRAYAIASSIISFYI-PLLIMIFVYLRVYREAKKQIKKIDKCEGrfhntltglgrkckrrpSRILALREQKALKTLGIIM 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121957962 240 GIFALCWLPVHTINCASLFqptWAKVKPKWAINTAILLSHANSAVNPIVYAyRNRDFRYTF 300
Cdd:cd15958  242 GVFTLCWLPFFLVNVVNVF---NRELVPDWLFVFFNWLGYANSAFNPIIYC-RSPDFRKAF 298
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
22-300 4.14e-36

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 130.93  E-value: 4.14e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL-GFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15053   15 VFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVnGGKWYLGPilCDIYIAMDVMCSTASIFNLCA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDrkiatncTEPGDAATnvscclirCLFENVvpm 178
Cdd:cd15053   95 ISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNN-------VPYRDPEE--------CRFYNP--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLpPLLIMLVIYVKIFLvacrqlqrtelmdhsrtVLQREIHAAKSLALIVGIFALCWLPVHTIN----- 253
Cdd:cd15053  157 DFIIYSSISSFYI-PCIVMLLLYYRIFR-----------------ALRREKKATKTLAIVLGVFLFCWLPFFTLNilnai 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 254 CASLFQPTwAKVKPKwAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15053  219 CPKLQNQS-CHVGPA-LFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
21-300 5.41e-35

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 127.93  E-value: 5.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCL---FLACFVLVLTqSSIFSLL 97
Cdd:cd15060   14 TIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLcqmWLTCDILCCT-ASILNLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDrkiatnctEPGDAATNVSCCLIRclfenvvP 177
Cdd:cd15060   93 AIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWND--------WPENFTETTPCTLTE-------E 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYfNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15060  158 KGYVIY-SSSGSFFIPLLIMTIVYVKIFIAT-----------------SKERRAARTLGIIMGVFVVCWLPFFLMYVILP 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 258 FQPTwAKVKPKWaINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15060  220 FCET-CSPSAKV-VNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
22-300 2.92e-34

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 126.79  E-value: 2.92e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15317   15 VSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDlfCKFHTGLDLLLCTTSIFHLCFI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVL-AFGIGLTPFLGWNDRKIatncTEPGDAATNVSCCLIrCLFENVVPM 178
Cdd:cd15317   95 AIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVpGIYTFGLIYTGANDEGL----EEYSSEISCVGGCQL-LFNKIWVLL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFnffgcvlPPLLIMLVIYVKIFLVACRQLQRTELMD---------HSRTVLQREIHAAKSLALIVGIFALCWLPv 249
Cdd:cd15317  170 DFLTFF-------IPCLIMIGLYAKIFLVARRQARKIQNMEdkfrsseenSSKASASRERKAAKTLAIVMGIFLFCWLP- 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 250 HTINcaSLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15317  242 YFID--TIVDEYSNFITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
21-300 5.98e-34

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 125.87  E-value: 5.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTqSSIFSLLA 98
Cdd:cd14972   12 IVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSvlLVSLTPSPATWLLRKGSLVLSLL-ASAYSLLA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdrkiATNCTEPgdaatnvSCCLIRCLFenvvPM 178
Cdd:cd14972   91 IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWN----CVLCDQE-------SCSPLGPGL----PK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFgcVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTV--LQREIHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd14972  156 SYLVLILVF--FFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPaqPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLD 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 257 LFQPTWA--KVKPKWAINTAILlshaNSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14972  234 VLCPSVCdiQAVFYYFLVLALL----NSAINPIIYAFRLKEMRRAV 275
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
24-300 3.15e-33

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 123.24  E-value: 3.15e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15061   16 GNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGShlCDFWISLDVLLCTASILNLCCISL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRkiatnctepgDAATNVSCCLIrclfenvvPMSYM 181
Cdd:cd15061   96 DRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWH----------GRRGLGSCYYT--------YDKGY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLP-----VHTINCAS 256
Cdd:cd15061  158 RIYSSMGSFFLPLLLMLFVYLRIFRVI-----------------AKERKTAKTLAIVVGCFIVCWLPffimyLIEPFCDC 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 257 LFQPtwakvkpkwAINTAIL-LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15061  221 QFSE---------ALSTAFTwLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
21-300 4.11e-33

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 123.08  E-value: 4.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIS-LG-------FCTDFHSCLFLACfvlvltQSS 92
Cdd:cd15326   14 AIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEiLGywvfgriFCDIWAAVDVLCC------TAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGW-----NDRKIATNCTEPgdaatnvsccl 167
Cdd:cd15326   88 ILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWkepapPDDKVCEITEEP----------- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 irclfenvvpmsYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRqlqrtelmdhsrtvLQREIHAAKSLALIVGIFALCWL 247
Cdd:cd15326  157 ------------FYALFSSLGSFYIPLIVILVMYCRVYIVALK--------------FSREKKAAKTLGIVVGMFILCWL 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 248 PVHT-INCASLFqptwAKVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15326  211 PFFIaLPLGSLF----SHLKPPETLFKIIFwLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
21-300 6.97e-33

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 123.12  E-value: 6.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLflaCFVLVLTQ-----SSIFS 95
Cdd:cd15207   14 CVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVM---CKLSPLVQgvsvaASVFT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  96 LLAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIGL--------TPFLGWNDRKIATnCTE--PGDAATNVsc 165
Cdd:cd15207   91 LVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMIpqalvlevKEYQFFRGQTVHI-CVEfwPSDEYRKA-- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 166 clirclfenvvpmsYMVYFnFFGCVLPPLLIMLVIYVKI-FLVACRQLQRTELMDHSR--TVLQREIHAAKSLALIVGIF 242
Cdd:cd15207  166 --------------YTTSL-FVLCYVAPLLIIAVLYVRIgYRLWFKPVPGGGSASREAqaAVSKKKVRVIKMLIVVVVLF 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121957962 243 ALCWLPVHTINCASLF---QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15207  231 ALSWLPLHTVTMLDDFgnlSPNQREVLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
22-300 1.92e-32

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 122.28  E-value: 1.92e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15957   15 VFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNfwCEFWTSIDVLCVTASIETLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAfgiGLTPFL----GW--NDRKIATNCTEpgdaatNVSCCLIRCLFE 173
Cdd:cd15957   95 AVDRYFAITSPFKYQSLLTKNKARVIILMVWIVS---GLTSFLpiqmHWyrATHQEAINCYA------EETCCDFFTNQA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVVPMSYMVYFnffgcvlPPLLIMLVIYVKIFLVACRQLQR---TELMDHSRTVLQ-----------------REIHAAK 233
Cdd:cd15957  166 YAIASSIVSFY-------VPLVIMVFVYSRVFQEAKRQLQKidkSEGRFHNQNIDQngsgggggnrrrskfclKEHKALK 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 234 SLALIVGIFALCWLPVHTINcasLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAyRNRDFRYTF 300
Cdd:cd15957  239 TLGIIMGTFTLCWLPFFIVN---IVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAF 301
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
21-300 2.03e-32

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 121.17  E-value: 2.03e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15327   14 AIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRvfCDIWAAVDVLCCTASILSLCV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWN-----DRKIATNCTEPGDAatnvscclircLFE 173
Cdd:cd15327   94 ISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKeppppDESICSITEEPGYA-----------LFS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVvpmsymvyFNFFgcvlPPLLIMLVIYVKIFLVACRqlqrtelmdhsrtvLQREIHAAKSLALIVGIFALCWLPVHTIN 253
Cdd:cd15327  163 SL--------FSFY----LPLMVILVMYFRVYVVALK--------------FSREKKAAKTLAIVVGVFILCWFPFFFVL 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 254 CASLFQPTwakVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15327  217 PLGSFFPA---LKPSEMVFKVIFwLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
21-300 3.10e-32

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 121.54  E-value: 3.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd14969   14 GVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYsnLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLvTGARARGVIAALWVLAFGIGLTPFLGWNdrkiatnctEPGDAATNVSCClIRCLFENVVPM 178
Cdd:cd14969   94 LAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWALPPLFGWS---------SYVPEGGGTSCS-VDWYSKDPNSL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLpPLLIMLVIYVKIFL----VACRQLQRTELMDHSRTvLQREIHAAKSLALIVGIFALCWLPVHTINC 254
Cdd:cd14969  163 SYIVSLFVFCFFL-PLAIIIFCYYKIYRtlrkMSKRAARRKNSAITKRT-KKAEKKVAKMVLVMIVAFLIAWTPYAVVSL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 255 ASLFQPtwAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14969  241 YVSFGG--ESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
21-300 1.01e-31

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 119.31  E-value: 1.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISLGFCTdfhscLFLACFVLVLTqSS 92
Cdd:cd15330   14 AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAAlyqvlnkwTLGQVTCD-----LFIALDVLCCT-SS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGW---NDRKIATNCTEPGDAAtnvscclir 169
Cdd:cd15330   88 ILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWrtpEDRSDPDACTISKDPG--------- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 clfenvvpmsYMVYfNFFGCVLPPLLIMLVIYVKIFLVACRQlqrtelmdhSRTVlqreihaaKSLALIVGIFALCWLPV 249
Cdd:cd15330  159 ----------YTIY-STFGAFYIPLILMLVLYGRIFKAAARE---------RKTV--------KTLGIIMGTFILCWLPF 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 250 HTIN-----CAS-LFQPTWAKVKPKWaintailLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15330  211 FIVAlvlpfCEStCHMPELLGAIINW-------LGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
21-300 5.24e-31

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 117.59  E-value: 5.24e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--------GFCTDFHSCLFLACfvlvltQSS 92
Cdd:cd15062   14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVlgywafgrIFCDVWAAVDVLCC------TAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRkiatnctepgdAATNVSCClirclf 172
Cdd:cd15062   88 IMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEP-----------APADEQAC------ 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 eNVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRqlqrtelmdhsrtvLQREIHAAKSLALIVGIFALCWLPVHTI 252
Cdd:cd15062  151 -GVNEEPGYVLFSSLGSFYLPLAIILVMYCRVYVVAFK--------------FSREKKAAKTLGIVVGAFVLCWFPFFVV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 253 NCASLFQPTWAKVKPKWAIntAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15062  216 LPLGSLFSTLKPPEPVFKV--VFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
22-300 1.64e-30

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 116.15  E-value: 1.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG--------FCTDFHSCLFLACfvlvltQSSI 93
Cdd:cd15325   15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILgywafgrvFCNIWAAVDVLCC------TASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWN-----DRKIATNCTEPGdaatnvsccli 168
Cdd:cd15325   89 MSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKepapeDETICQITEEPG----------- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 169 rclfenvvpmsyMVYFNFFGCVLPPLLIMLVIYVKIFLVACRqlqrtelmdhsrtvLQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd15325  158 ------------YALFSALGSFYLPLAIILVMYCRVYVVALK--------------FSREKKAAKTLGIVVGCFVLCWLP 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 249 VHTINCASLFQPTWAKVKPKWAIntAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15325  212 FFLVMPIGSIFPAYKPSDTVFKI--TFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
22-300 3.23e-29

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 112.79  E-value: 3.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG---FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15052   15 IGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFggvWPLPLVLCLLWVTLDVLFCTASIMHLCT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGL-TPFLGWNDrkiatnctePGDAATNVSCclirclfenVVP 177
Cdd:cd15052   95 ISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSpIPVLGIID---------TTNVLNNGTC---------VLF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLPPLLIMLVIYVKiflvacrqlqrtelmdhSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15052  157 NPNFVIYGSIVAFFIPLLIMVVTYAL-----------------TIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTG 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 258 FQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15052  220 LCEECNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
21-300 5.24e-29

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 112.41  E-value: 5.24e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP-FAVTISLGFCT-DFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15049   14 TVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNlYTVYLVMGYWPlGPLLCDLWLALDYVASNASVMNLLL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndRKIATNCTEPGDAatnvscCLIRCLFENVVPM 178
Cdd:cd15049   94 ISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGW--QYFVGERTVPDGQ------CYIQFLDDPAITF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 -SYMVYFNFfgcvlpPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTIncaSL 257
Cdd:cd15049  166 gTAIAAFYL------PVLVMTILYWRIYRET-----------------ARERKAARTLSAILLAFIITWTPYNIL---VL 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 258 FQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15049  220 VSTFCAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
21-300 9.46e-29

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 112.20  E-value: 9.46e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15056   14 TILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGEtfCLVRTSLDVLLTTASIMHLCC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLA-VRVPLRYKslVTGARARGVIAALWVLAFGIGLTPFL-GWNdrKIATNCTEPGDAATNVSCCLIRCLFENVV 176
Cdd:cd15056   94 IALDRYYAiCCQPLVYK--MTPLRVAVMLGGCWVIPTFISFLPIMqGWN--HIGIEDLIAFNCASGSTSCVFMVNKPFAI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFnffgcvlPPLLIMLVIYVKIFLVACRQLQRTELMD-----------HSRTVLQREIHAAKSLALIVGIFALC 245
Cdd:cd15056  170 ICSTVAFY-------IPALLMVLAYYRIYVAAREQAHQIRSLQragssnheadqHRNSRMRTETKAAKTLGIIMGCFCVC 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 246 WLPVHTINCASLFQPTWAKVKPkWAIntAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15056  243 WAPFFVTNIVDPFIGYRVPYLL-WTA--FLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
21-300 1.04e-28

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 111.70  E-value: 1.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG--------FCTDFHSCLFLACFVlvltqsS 92
Cdd:cd15066   13 AIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITgrwmfgyfMCDVWNSLDVYFSTA------S 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTP-FLGW-----NDRKIATNCTEpgdaatnvscc 166
Cdd:cd15066   87 ILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPiFLGWytteeHLQYRKTHPDQ----------- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 167 lirCLFenVVPMSYMVY---FNFFgcvlPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFA 243
Cdd:cd15066  156 ---CEF--VVNKIYALIsssVSFW----IPCIVMIFTYYRIYLEA-----------------KREHKAAKTLGIIMGAFI 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121957962 244 LCWLP-----VHTINCASLFQptwakvKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15066  210 LCWLPfflwyVTTTLCGDACP------YPPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
21-300 1.12e-28

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 112.79  E-value: 1.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTP-TNYFLVSLAAADVAVGLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15320   15 TLLGNTLVCAAVIRFRHLRSKvTNFFVISLAVSDLLVAVLVMPWkAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPF-LGWNDRKIAT----NCTEPGDAATNVSCCLIRCLFE 173
Cdd:cd15320   95 ISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVqLNWHKAKPTSfldlNASLRDLTMDNCDSSLNRTYAI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVVPMSYMVyfnffgcvlpPLLIMLVIYVKIFLVACRQLQRTELMDHS--------------------------RTVLQR 227
Cdd:cd15320  175 SSSLISFYI----------PVAIMIVTYTRIYRIAQKQIRRISALERAavhakncqnstgnrgsgdcqqpessfKMSFKR 244
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 228 EIHAAKSLALIVGIFALCWLPVHTINCASLF-QPTWAK---VKPKwAINTAILLSHANSAVNPIVYAYrNRDFRYTF 300
Cdd:cd15320  245 ETKVLKTLSVIMGVFVCCWLPFFILNCMVPFcKPTSTEpfcISST-TFDVFVWFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
21-300 4.21e-28

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 110.01  E-value: 4.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSC---LFLACFVLVLTqSSIFSLL 97
Cdd:cd15321   20 TIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTwceIYLALDVLFCT-SSIVHLC 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKiatnctepGDAATNVSCCLIRclfenvvp 177
Cdd:cd15321   99 AISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQK--------DEQGGLPQCKLNE-------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMdhsrtvlqreihaaksLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15321  163 EAWYILSSSIGSFFAPCLIMILVYLRIYLIAKNREKRFTFV----------------LAVVIGVFVLCWFPFFFSYSLGA 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 258 FQPTWAKVkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15321  227 ICPELCKV-PHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
22-300 7.99e-28

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 108.98  E-value: 7.99e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--TISLGFCTDFHSCLFLACF-VLVLTqSSIFSLLA 98
Cdd:cd15331   15 IIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAvyEVSQHWFLGPEVCDMWISMdVLCCT-ASILHLVA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVrVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDaatnvscCLIRclfenvVPM 178
Cdd:cd15331   94 IALDRYWAV-TNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEDDLDRVLKTGV-------CLIS------QDY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVyFNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15331  160 GYTI-FSTVGAFYVPLLLMIIIYWKIYQAA-----------------KRERKAARTLAIITGAFVVCWLPFFLVALVMPF 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWakVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15331  222 CGAW--QISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
22-300 1.00e-27

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 108.90  E-value: 1.00e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFV---LVLTQSSIFSLLA 98
Cdd:cd15310   15 VFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVtldVMMCTASILNLCA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGV---IAALWVLAFGIGLTPFLGWNdrkiatnctEPGDAATnvscclirCLFENV 175
Cdd:cd15310   95 ISIDRYTAVVMPVHYQHGTGQSSCRRVslmITAVWVLAFAVSCPLLFGFN---------TTGDPTV--------CSISNP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVYFNFFgcvlPPLLIMLVIYVKIFLvacrqlqrtelmdhsrtVLQREIHAAKSLALIVGIFALCWLP---VHTI 252
Cdd:cd15310  158 DFVIYSSVVSFY----LPFGVTLLVYVRIYV-----------------VLLREKKATQMLAIVLGAFIVCWLPfflTHIL 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 253 N--CASLFQPTWAKVKPKWaintailLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15310  217 NthCQACHVPPELYSATTW-------LGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
21-300 3.46e-27

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 107.82  E-value: 3.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15312   14 TVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDlfCKIHSSLDMMLSTTSIFHLCF 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALW----VLAFGIGLTP--FLGWNDRKIATNCTEpgdaatnvSCCLIrclf 172
Cdd:cd15312   94 IAVDRYYAVCDPLHYRTKITTPVIKVFLVISWsvpcLFAFGVVFSEvnLEGIEDYVALVSCTG--------SCVLI---- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 envvpmsymvyFN-------FFGCVLPPLLIMLVIYVKIFLVACRQLQ-------RTELMDHSRTVLQREIHAAKSLALI 238
Cdd:cd15312  162 -----------FNklwgviaSLIAFFIPGTVMIGIYIKIFFVARKHAKvinnrpsVTKGDSKNKLSKKKERKAAKTLSIV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121957962 239 VGIFALCWLPVHTincASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15312  231 MGVFLLCWLPFFV---ATLIDPFLNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
21-297 3.47e-26

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 105.33  E-value: 3.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15316   14 AVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGEsfCTFHTCCDVSFCYASLFHLCF 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFL-GWNDRKIatncTEPGDAATNVSCCLIrCLFENVVP 177
Cdd:cd15316   94 ISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYtGVNDDGL----EELVNALNCVGGCQI-ILNQNWVL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFnffgcvlPPLLIMLVIYVKIFLVACRQLQRTELM---------DHSRTVLQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd15316  169 VDFLLFF-------IPTFAMIILYGKIFLVAKQQARKIEMTsskaessseSYKDRVARRERKAAKTLGITVIAFLVSWLP 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 121957962 249 VHTIncaSLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15316  242 YLID---VLIDAFMNFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFR 287
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
24-300 1.55e-25

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 104.27  E-value: 1.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTP-TNYFLVSLAAADVAVGLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15319   17 GNILVCAAVVRFRHLRSKvTNIFIVSLAVSDLFVALLVMPWkAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPF-LGWN-----DRKIATNCTEPGDAATNVSCCLIRCLFENV 175
Cdd:cd15319   97 DRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVqLNWHkdsgdDWVGLHNSSISRQVEENCDSSLNRTYAISS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVyfnffgcvlpPLLIMLVIYVKIFLVACRQLQRTELMDHS--------------------RTVLQREIHAAKSL 235
Cdd:cd15319  177 SLISFYI----------PVAIMIVTYTRIYRIAQIQIRRISSLERAaehaqscrsnridchhhtslRTSIKKETKVLKTL 246
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121957962 236 ALIVGIFALCWLPVHTINCASLFQPTWAKVKP-------KWAINTAILLSHANSAVNPIVYAYrNRDFRYTF 300
Cdd:cd15319  247 SVIMGVFVCCWLPFFILNCMVPFCDRPPADPDaglpcvsETTFDVFVWFGWANSSLNPIIYAF-NADFRKVF 317
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-300 2.75e-25

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 103.24  E-value: 2.75e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15208   17 GNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPatLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSlvTGARARGVIAALWVLAFGIGLTpflgwndRKIATNCTEPGDAATNVScCLIRCLFENVVPMSYM 181
Cdd:cd15208   97 DRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMIP-------QAIVMECSRVVPLANKTI-LLTVCDERWSDSIYQK 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VY--FNFFGCVLPPLLIMLVIYVKIFLV----------ACRQLQRTELMDHS----RTVLQREIHAAKSLALIVGIFALC 245
Cdd:cd15208  167 VYhiCFFLVTYLLPLCLMILAYFQIFRKlwcrqipgtsSVVQRKWNKPRKSAvaaeEKQLRSRRKTAKMLIVVVIMFAIC 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 246 WLPVHTIN----CASLFQPTWAKVKpKWAInTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15208  247 YLPVHLLNilryVFGLFTVDRETIY-AWFL-FSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
22-300 3.31e-25

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 101.84  E-value: 3.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL---GFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15308   15 IAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFqggVWTLSPVLCDALMTMDVMLCTASIFNLCA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDrkiatnctEPGDAATnvsccliRCLFENVVPM 178
Cdd:cd15308   95 ISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNN--------VPNRDPA-------VCKLEDNNYV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFgcvlPPLLIMLVIYVKIFlvacrqlqrtelmdhsrTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15308  160 VYSSVCSFF----IPCPVMLVLYCAMF-----------------RGLGRERKAMRVLPVVVGAFLFCWTPFFVVHITRAL 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAkvKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15308  219 CESCS--IPPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
21-300 3.80e-25

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 102.37  E-value: 3.80e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--------GFCTdfhsclfLACFVLVLTQS- 91
Cdd:cd15390   14 AIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLyndwpfglFYCK-------FSNFVAITTVAa 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKslvTGAR-ARGVIAALWVLAFGIGLTPFLgwndrkIATNCTEPGDAATNVSCCLIRc 170
Cdd:cd15390   87 SVFTLMAISIDRYIAIVHPLRPR---LSRRtTKIAIAVIWLASFLLALPQLL------YSTTETYYYYTGSERTVCFIA- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 LFENVVPMSYMVYFNFFGCVL--PPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd15390  157 WPDGPNSLQDFVYNIVLFVVTyfLPLIIMAVAYTRVGVELWGSKTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLP 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 121957962 249 VHTINCASLFQPTWAKVKPKWAINTAI-LLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15390  237 YHLYFILTYLYPDINSWKYIQQIYLAIyWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
22-300 4.52e-25

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 102.36  E-value: 4.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDF--HSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15095   15 LAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFgdFMCKFVNYMMQVTVQATCLTLTAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGlTPFL------GWNDRKIATNCTEPGDAATnvscclirclFE 173
Cdd:cd15095   95 SVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLS-IPVAiyyrleEGYWYGPQTYCREVWPSKA----------FQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVvpmsYMVYfNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDH--SRTVLQREIHAAKSLALIVGIFALCWLPVHT 251
Cdd:cd15095  164 KA----YMIY-TVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEqlSERALRQKRKVTRMVIVVVVLFAICWLPNHV 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 252 INCASLFQPTWAKVKPKWAINT-AILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15095  239 LNLWQRFDPNFPETYATYALKIaALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
21-300 5.51e-25

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 101.70  E-value: 5.51e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--TISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15206   14 AVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLvgQLLRNFIFGEVMCKLIPYFQAVSVSVSTFTLVA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIgLTPFLGWNDrkiatncTEPGDAATNVSCcliRCLFEN-VVP 177
Cdd:cd15206   94 ISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLI-MSPILVFSN-------LIPMSRPGGHKC---REVWPNeIAE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLpPLLIMLVIYVKIflvacrqlqrtelmdhSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15206  163 QAWYVFLDLMLLVI-PGLVMSVAYGLI----------------SWTLLEAKKRVIRMLFVIVVEFFICWTPLYVINTWKA 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 258 FQPtwaKVKPKWAINTAI----LLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15206  226 FDP---PSAARYVSSTTIsliqLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
22-300 6.97e-25

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 102.00  E-value: 6.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISLGFCTDFHSCLFLACfvlvltQSSI 93
Cdd:cd15048   15 VIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIpytltgkwPFGKVFCKAWLVVDYTLC------TASA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWnDRKIATNCTEPGDaatnvsCclirclfe 173
Cdd:cd15048   89 LTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGW-DLWTGYSIVPTGD------C-------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 nVVPMSYMVYFNFFGCVLP---PLLIMLVIYVKIFLVACRQLQRTELMDHS----------------RTVLQREIHAAKS 234
Cdd:cd15048  154 -EVEFFDHFYFTFITSVLEffiPFISVSFFNLLIYLNIRKRSRRRPLRSVPilpasqnpsrarsqreQVKLRRDRKAAKS 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 235 LALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLShaNSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15048  233 LAILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWT--NSAINPFLYAACHPRFRKAF 296
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
22-297 1.81e-24

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 100.32  E-value: 1.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15318   15 VLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDsfCRLHTCLDTLFCLTSIFHLCFI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAfgIGLTPFLGWNDrKIATNCTEPGDAATNVSCCliRCLFENVVP-M 178
Cdd:cd15318   95 SIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVP--TVYTSVFLYTK-AVEEGLAELLTSVPCVGSC--QLLYNKLWGwL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFnffgcvlPPLLIMLVIYVKIFLVACRQLQRTELMDHS-RTVLQREIHAAKSLALIVGIFALCWLPVhTINcaSL 257
Cdd:cd15318  170 NFPVFF-------IPCLIMIGLYVKIFIVAKRQARAIASLLSDtNGASKRERKAAKTLGIAVGVYLLCWLPF-TID--TM 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 121957962 258 FQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15318  240 VDSLLNFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFR 279
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
21-304 2.37e-24

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 100.03  E-value: 2.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFA-VTISLG-FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15307   14 TAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGiLTLVKGhFPLSSEHCLTWICLDVLFCTASIMHLCT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdrkiatncTEPGDAATNVSCclirclfenVVPM 178
Cdd:cd15307   94 ISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYS--------KDHASVLVNGTC---------QIPD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRtelmdHSRtVLQREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15307  157 PVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSR-----HGR-IIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTV 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 259 QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKII 304
Cdd:cd15307  231 CAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
8-300 3.04e-24

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 100.13  E-value: 3.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAvtislgfctdFHSCLFLA----- 82
Cdd:cd15392    1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFS----------FIALLILQywpfg 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  83 ---CFVLVLTQS-----SIFSLLAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIGLtPFLgwndrkIATNCT 154
Cdd:cd15392   71 efmCPVVNYLQAvsvfvSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATAL-PIA------ITSRLF 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 155 EPGDAATNVSCCLirclfENVVPMSYMVYFNFFGCVLP---PLLIMLVIYVKI-FLVACRQLQRTELMDHSRTVLQREIH 230
Cdd:cd15392  142 EDSNASCGQYICT-----ESWPSDTNRYIYSLVLMILQyfvPLAVLVFTYTRIgIVVWAKRTPGEAENNRDQRMAESKRK 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121957962 231 AAKSLALIVGIFALCWLPVHTINCASLFQPT---WAKVKPKWAinTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15392  217 LVKMMITVVAIFALCWLPLNILNLVGDHDESiysWPYIPYLWL--AAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
21-297 5.21e-24

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 99.22  E-value: 5.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFavTISLGFCTDFH----SCLFLACFVLVLTQSSIFSL 96
Cdd:cd15203   14 GVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPF--TLIYTLTKNWPfgsiLCKLVPSLQGVSIFVSTLTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIGLtPFLgwndrkIATNCTEpgDAATNVSCCLIRClFENVV 176
Cdd:cd15203   92 TAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSL-PLA------IFQELSD--VPIEILPYCGYFC-TESWP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGCVLP---PLLIMLVIYVKIFL-----VACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd15203  160 SSSSRLIYTISVLVLQfviPLLIISFCYFRISLklrkrVKKKRGKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLP 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 249 VHTINCASLFQPTWAKVKPKWAINTAI--LLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15203  240 LNLFNLLRDFEPLPQIDGRHFYLIFLIchLIAMSSACVNPLLYGWLNDNFR 290
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
21-300 5.43e-24

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 98.86  E-value: 5.43e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL---GFCTDFHSCLFLACFVLVLTqSSIFSLL 97
Cdd:cd15323   14 TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELmgyWYFGQVWCNIYLALDVLFCT-SSIVHLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRkiatnctePGDAAtnvsccLIRCLFENvvp 177
Cdd:cd15323   93 AISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRD--------PEGDV------YPQCKLND--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMdhsrtvlqreihaaksLALIVGIFALCWLPVhtINCASL 257
Cdd:cd15323  156 ETWYILSSCIGSFFAPCLIMILVYIRIYRVAKAREKRFTFV----------------LAVVMGVFVVCWFPF--FFSYSL 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 121957962 258 FQPTWAKVK-PKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15323  218 YGICREACEvPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
21-300 8.99e-24

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 98.66  E-value: 8.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd14992   14 SVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHflCKIVNYLRTVSVYASSLTLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWndrkiATNCTEPGDAATNVSCCLIRCLFENVVPM 178
Cdd:cd14992   94 IAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSL-LLAIPQLYY-----ATTEVLFSVKNQEKIFCCQIPPVDNKTYE 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLPPLLIMLVIYVKI-FLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd14992  168 KVYFLLIFVVIFVLPLIVMTLAYARIsRELWFRKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRD 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 258 FQPTWAKVKpkwAINTAILLSH----ANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14992  248 FFPLIMKEK---HTLQVYYFLHwiamSNSMYNPIIYVTLNNNFRKNF 291
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
21-300 1.28e-23

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 97.88  E-value: 1.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG--FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15050   14 TVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLEskWILGRPVCLFWLSMDYVASTASIFSLFI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWNDRKIATNCTEPGDAATNVscclirclFENVVPM 178
Cdd:cd15050   94 LCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSF-LWVIPILGWHHFARGGERVVLEDKCETD--------FHDVTWF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYF-NFFgcvlPPLLIMLVIYVKIFLvacrqlqrtelmdhsrtVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15050  165 KVLTAIlNFY----IPSLLMLWFYAKIFK-----------------AVNRERKAAKQLGFIMAAFILCWIPYFILFMVIA 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 258 FQPTWAKVKPKWAIntaILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15050  224 FCKNCCNENLHMFT---IWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
8-300 1.29e-23

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 97.63  E-value: 1.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFV 85
Cdd:cd15324    1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGStwCAFYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  86 LVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwNDRKIATNCTEPGDAATNVSC 165
Cdd:cd15324   81 VLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL--MTKHDEWECLLNDETWYILSS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 166 CLIrclfenvvpmsymvyfNFFGcvlpPLLIMLVIYVKIFLVACRQLQRTELMdhsrtvlqreihaaksLALIVGIFALC 245
Cdd:cd15324  159 CTV----------------SFFA----PGLIMILVYCKIYRVAKMREKRFTFV----------------LAVVMGVFVLC 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121957962 246 WLP------VHTInCASLFQPtwakvkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15324  203 WFPffftysLHAV-CRKRCGI------PDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
21-300 1.30e-23

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 97.97  E-value: 1.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP-FAVTISLGFCT-DFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15301   14 TVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPlFTVYTALGYWPlGYEVCDTWLAIDYLASNASVLNLLI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdrKIATNCTEPGDAatnvscCLIRCLFENVvpm 178
Cdd:cd15301   94 ISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWP--YIEGKRTVPAGT------CYIQFLETNP--- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 sYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRtelmdhsrtvlqREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15301  163 -YVTFGTALAAFYVPVTIMCILYWRIWRETKKRQKK------------QESKAAKTLSAILLAFIVTWTPYNVLVLIKAF 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAKVkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15301  230 FPCSDTI-PTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
21-310 1.37e-23

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 97.98  E-value: 1.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFA-VTISLGFCTDFHSCLFLACFVL--VLTQSSIFSLL 97
Cdd:cd15306   14 TIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIAlLTILFEAMWPLPLVLCPIWLFLdvLFSTASIMHLC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGL-TPFLGWNDrkiatnctePGDAATNVSCCLirclfeNVV 176
Cdd:cd15306   94 AISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIpVPIKGIET---------DVDNPNNITCVL------TKE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGCVLPPLLIMLVIYvkifLVACRQLQRTELMDHSRtvlqreihAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15306  159 RFGDFILFGSLAAFFTPLAIMIVTY----FLTIHALRKQTITNEQR--------ASKVLGIVFFLFLLMWCPFFITNITS 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 257 LFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFhkiiSRYILC 310
Cdd:cd15306  227 VLCDSCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAF----GRYITC 276
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
21-300 1.70e-23

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 97.96  E-value: 1.70e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--------ISLGFCtdfHSCLFL-ACFVLVltqs 91
Cdd:cd15202   14 SLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVravnntwiFGLFMC---HFSNFAqYCSVHV---- 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLryKSLVTGARARGVIAALWVLAFGIGLTP--FLGWNDRKIATNCTEPgdaatnvsCCLI- 168
Cdd:cd15202   87 SAYTLTAIAVDRYQAIMHPL--KPRISKTKAKFIIAVIWTLALAFALPHaiCSKLETFKYSEDIVRS--------LCLEd 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 169 ----RCLFENVVPMSYMVYFNFFgcvlpPLLIMLVIY--VKIFLVACRQLQRTElMDHSRTVLQREIHAAKSLALIVGIF 242
Cdd:cd15202  157 wperADLFWKYYDLALFILQYFL-----PLLVISFAYarVGIKLWASNMPGDAT-TERYFALRRKKKKVIKMLMVVVVLF 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 243 ALCWLPVHTINCASLFQPTwAKVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15202  231 ALCWLPFNIYVLLLSSKPD-YLIKTINAVYFAFHwLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
22-300 3.46e-23

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 96.77  E-value: 3.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd14971   15 LVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPlpGWVFGDFMCKFVHYFQQVSMHASIFTLVAM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtpflgwndrKIATNCTEPGDAATNVSCCLIrcLFENVVPMS 179
Cdd:cd14971   95 SLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA---------PVLALHRLRNYTPGNRTVCSE--AWPSRAHRR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQReihAAKSLALIVGIFALCWLPVHTINCASLFQ 259
Cdd:cd14971  164 AFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKRK---VTRLVLVVVVLFAACWGPIHAILLLVALG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121957962 260 PTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14971  241 PFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
21-297 4.21e-23

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 97.02  E-value: 4.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG--FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15083   14 GVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSgrWIFGKTGCDMYGFSGGLFGIMSINTLAA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWND---RKIATNCTepgdaatnvscclIRCLFENV 175
Cdd:cd15083   94 IAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRyvlEGLLTSCS-------------FDYLSRDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVYFNFFGCVLpPLLIMLVIYVKIFL--VACRQLQRTELMDHSRTVL-------QREIHAAKSLALIVGIFALCW 246
Cdd:cd15083  161 ANRSYVICLLIFGFVL-PLLIIIYCYSFIFRavRRHEKAMKEMAKRFSKSELsspkarrQAEVKTAKIALLLVLLFCLAW 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 247 LPVHTINCASLFQPtwAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15083  240 TPYAVVALIGQFGY--LEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFR 288
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
25-295 4.57e-23

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 96.39  E-value: 4.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIslgFCTDFHSCLFLACFVLVLTQS-SIFSLLAVAVDR 103
Cdd:cd15100   18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLILHFVFR---YCVYSEALSLVSVGLLVAAFSaSVCSLLAITVDR 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 104 YLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndrkiatNCTEPGDaatnvSCCLIRCLFENVVPMSYMVY 183
Cdd:cd15100   95 YLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGW-------NCLREGS-----SCSVVRPLTKNHLAVLAVAF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 184 FNFFGcvlppllIMLVIYVKIFLVACRQLQRTELMDH-----SRTVLQREIHaakSLALIVGIFALCWLPVhtincaSLF 258
Cdd:cd15100  163 LLVFA-------LMLQLYAQICRIVLRHAHQIALQRHflapsHYVATRKGVS---TLALILGTFAACWIPF------AVY 226
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121957962 259 QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRD 295
Cdd:cd15100  227 CLLGDGSSPALYTYATLLPATYNSMINPIIYAFRNQD 263
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
21-300 6.40e-23

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 96.04  E-value: 6.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15979   14 SVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLmgTFIFGEVICKAVAYLMGVSVSVSTFSLVA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIgLTPFLGWNDRKiatncTEPGDAATNVSCCLIRCLFENVVPM 178
Cdd:cd15979   94 IAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLI-MIPYPVYSVTV-----PVPVGDRPRGHQCRHAWPSAQVRQA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVlpPLLIMLVIYVKIflvaCRQLQRTeLMDHSRTVlqreihaaKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15979  168 WYVLLLLILFFI--PGVVMIVAYGLI----SRELYRG-LLAKKRVI--------RMLVVIVAMFFLCWLPIFSANTWRAF 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 259 QPTWAKVKPKWA-INTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15979  233 DPLSAHRALSGApISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
21-300 6.68e-23

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 96.32  E-value: 6.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDF-HSCLFLACFVLVLTQS-SIFSLLA 98
Cdd:cd15393   14 AVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLpRFMCPFCPFVQVLSVNvSVFTLTV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLryKSLVTGARARGVIAALWVLAFGIGLtPFLgwndrkIATNCTEPGDAATNVSccLIRCLFENVVPM 178
Cdd:cd15393   94 IAVDRYRAVIHPL--KARCSKKSAKIIILIIWILALLVAL-PVA------LALRVEELTDKTNNGV--KPFCLPVGPSDD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCV--LPPLLIMLVIYVKIfLVACRQLQRTELMDHSR--TVLQREIHAAKSLALIVGIFALCWLPVHTINC 254
Cdd:cd15393  163 WWKIYNLYLVCVqyFVPLVIICYAYTRI-AVKIWGTKAPGNAQDVRddEILKNKKKVIKMLIIVVALFALCWLPLQTYNL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 255 ASLFQPTWAKVKpkwAINTAILLSH----ANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15393  242 LNEIKPEINKYK---YINIIWFCSHwlamSNSCYNPFIYGLYNEKFKREF 288
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
22-300 1.29e-22

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 94.72  E-value: 1.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDF---HSCLFLACFVLVLTqSSIFSLLA 98
Cdd:cd15309   15 VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFsriHCDIFVTLDVMMCT-ASILNLCA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGV-IAALWVLAFGIGLTPFLGWNDrkiatnctepgdaaTNVSCCLIrclfENVVP 177
Cdd:cd15309   94 ISIDRYTAVAMPMLYNTRYSSKRRVTVmISVVWVLSFAISCPLLFGLNN--------------TDQNECII----ANPAF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFgcvlPPLLIMLVIYVKIFLvacrqlqrtelmdhsrtVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15309  156 VVYSSIVSFY----VPFIVTLLVYVQIYI-----------------VLQKEKKATQMLAIVLGVFIICWLPFFITHILNM 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 258 FQPTWAkvkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15309  215 HCDCNI---PPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
21-310 1.94e-22

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 94.97  E-value: 1.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFA-VTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLL 97
Cdd:cd15305   14 TIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSlIAILYDYAWPLPRylCPIWISLDVLFSTASIMHLC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGL-TPFLGWNDRKiatnctepgDAATNVSCCLIRCLFenVV 176
Cdd:cd15305   94 AISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMpIPVIGLQDDE---------KVFVNGTCVLNDENF--VL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFnffgcvlPPLLIMLVIYVkiflVACRQLQRTELMDHSRtvlqreiHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15305  163 IGSFVAFF-------IPLIIMVITYC----LTIQVLQRQQAINNER-------RASKVLGIVFFLFLIMWCPFFITNILS 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 257 -LFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFhkiiSRYILC 310
Cdd:cd15305  225 vLCKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAF----SNYIRC 275
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
23-300 2.18e-22

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 94.67  E-value: 2.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  23 TGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVTISLGfcTDFHSCLFLACFVLVLTQ----SSIFSLLA 98
Cdd:cd14970   16 TGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLL--GYWPFGEVMCKIVLSVDAynmfTSIFCLTV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkIATNCTEPGDAatnVSCCLIRCLFENVVPM 178
Cdd:cd14970   93 MSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVII------FARTLQEEGGT---ISCNLQWPDPPDYWGR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRTElmDHSRTVLQREIHAAKSLALIVGIFALCWLPVHtincasLF 258
Cdd:cd14970  164 VFTIYTFVLGFAV-PLLVITVCYSLIIRRLRSSRNLST--SGAREKRRARRKVTRLVLVVVAVFVVCWLPFH------VF 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 259 QPTWAKVKPK---WAI---NTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14970  235 QIVRLLIDPPetlTVVgvfLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
21-300 2.69e-22

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 94.55  E-value: 2.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15978   14 SVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLlkDFIFGSAVCKTATYFMGISVSVSTFNLVA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIgLTPFlgwndrKIATNCTePGDAATNVSCCLIRCLFENVVPM 178
Cdd:cd15978   94 ISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTI-MLPY------PIYSNLV-PFTRINNSTGNMCRLLWPNDVTQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRteLMDHSRTVlqreihaaKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15978  166 QSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIKF--LMAKKRVI--------RMLIVIVILFFLCWTPIFSANAWRAF 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 259 QPTWAKVKPKWA-INTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15978  236 DTRSADRLLSGApISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
22-300 6.59e-22

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 93.96  E-value: 6.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL---------GFCTdFHSCLFLACfvlvlTQSS 92
Cdd:cd14979   15 IVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwqypwafgdGGCK-LYYFLFEAC-----TYAT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNCTEPGDAATNVscCLIRCLF 172
Cdd:cd14979   89 VLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAI-PILFLMGIQYLNGPLPGPVPDSAV--CTLVVDR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYFNFFgcVLPplliMLVIYVKIFLVACRqLQRTELMDHSRTVL-----------QREIHAAKSLALIVGI 241
Cdd:cd14979  166 STFKYVFQVSTFIFF--VLP----MFVISILYFRIGVK-LRSMRNIKKGTRAQgtrnvelslsqQARRQVVKMLGAVVIA 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 242 FALCWLPVHTincaslfQPTWAKVKPKWAIN----------TAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14979  239 FFVCWLPFHA-------QRLMFSYASKEDTFlfdfyqylypISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
21-300 6.69e-22

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 93.09  E-value: 6.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSC---LFLACFVLVLTqSSIFSLL 97
Cdd:cd15322   14 TVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVwceIYLALDVLFCT-SSIVHLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrKIATNCTEPGDAATNVScclirclfenvvP 177
Cdd:cd15322   93 AISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-----TIEKKSGQPEGPICKIN------------D 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMdhsrtvlqreihaaksLALIVGIFALCWLPVhtincasL 257
Cdd:cd15322  156 EKWYIISSCIGSFFAPCLIMVLVYIRIYQIAKNREKRFTFV----------------LAVVIGVFVICWFPF-------F 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 258 FQPTWAKVK----PKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15322  213 FTYTLTAVCdcsvPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
21-300 9.89e-22

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 92.72  E-value: 9.89e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT-ISLG-FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd17790   14 TVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTyILMGhWALGTVACDLWLALDYVASNASVMNLLI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdRKIATNCTEPGDaatnvscCLIRCLFENVVPM 178
Cdd:cd17790   94 ISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQ-YLVGERTVLAGQ-------CYIQFLSQPIITF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFgcvlpPLLIMLVIYVKIFlvacrqlqrtelmdhSRTVlqREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd17790  166 GTAIAAFYL-----PVTIMIILYWRIY---------------RETI--KEKKAARTLSAILLAFILTWTPYNIMVLVSTF 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAkvkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd17790  224 CKDCV---PKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
21-297 1.13e-21

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 92.96  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15391   14 SVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPApmCPIVLYVQLVSVTASVLTNTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRykSLVTGARARGVIAALWVLAFG-------IGLTPFLGWnDRKIATNCTE--PGDAATnvsccliR 169
Cdd:cd15391   94 IGIDRFFAVIFPLR--SRHTKSRTKCIIASIWAISFSlssvqlfAGRTQRYGQ-YSEGRVLCGEswPGPDTS-------R 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 CLFENVVpmsymvyfnFFGCVLPPLLIMLVIYVKI-FLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd15391  164 SAYTVFV---------MLLTYIIPLLILTSTYGYVgFRLWNRTAPGNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLP 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 249 VHTINCASLFQPTWAKVKP--KWAINTA-ILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15391  235 LHLFNLVQDFSTVFRNMPQhtTRLIYGAcHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
22-300 1.69e-21

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 92.48  E-value: 1.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQ--TPTNYFLVSLAAADVAVGLFAIPFAVTI-SL-GFCTDFHSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15098   15 VLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLFFLLFCVPFQATIySLpEWVFGAFMCKFVHYFFTVSMLVSIFTLV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGlTPFLGWNDrkIATNCTEPGdaatnvsccLIRCLFENVVP 177
Cdd:cd15098   95 AMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMA-SPVAVHQD--LVHHWTASN---------QTFCWENWPEK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNF---FGCVLpPLLIMLVIYVKIFLVACRQLQrtELMDHSRTVLQReihAAKSLALIVGIFALCWLPVHTINc 254
Cdd:cd15098  163 QQKPVYVVCtfvFGYLL-PLLLITFCYAKVLNHLHKKLK--NMSKKSERSKKK---TAQTVLVVVVVFGISWLPHHIIH- 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 255 aslfqpTWAKVKpKWAIN--------TAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15098  236 ------LWVEFG-DFPLTqasfvlriTAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
21-300 2.36e-21

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 91.53  E-value: 2.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFA-VTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLL 97
Cdd:cd15304   14 TIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSmLTILYGYRWPLPSklCAVWIYLDVLFSTASIMHLC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGL-TPFLGWNDRKiatnctepgDAATNVSCCLIRclfENVV 176
Cdd:cd15304   94 AISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMpIPVFGLQDDS---------KVFKEGSCLLAD---ENFV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFnffgcvLPPLLIMLVIYvkifLVACRQLQRTelmdhsrtvLQREIHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15304  162 LIGSFVAF------FIPLTIMVITY----FLTIKSLQQS---------ISNEQKASKVLGIVFFLFVVMWCPFFITNVMA 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 257 LF-QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15304  223 VIcKESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
25-297 3.89e-21

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 91.15  E-value: 3.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGL-----FAIPFAV---TISLgfctdfhsclFLACFVLVLTQSSIFSL 96
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCglilnFVFQYVIqseTISL----------ITVGFLVASFTASVSSL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndrkiatNCTEpgdaaTNVSCCLIRCLFENVV 176
Cdd:cd15962   88 LAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGW-------NCLE-----ERASCSIVRPLTKSNV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGcvlppllIMLVIYVKIFLVACRQLQRTELMDHSRTV--LQREIHAAKSLALIVGIFALCWLPVhTINC 254
Cdd:cd15962  156 TLLSASFFFIFI-------LMLHLYIKICKIVCRHAHQIALQQHFLTAshYVATKKGVSTLAIILGTFGASWLPF-AIYC 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 255 AslfqpTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15962  228 V-----VGDHEYPAVYTYATLLPATYNSMINPIIYAYRNQEIQ 265
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
22-300 4.93e-21

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 90.80  E-value: 4.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPF--AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15001   14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLktAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPgdaatnVSCCLIRCLFEnVVPMS 179
Cdd:cd15001   94 SIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVT------VYHCQKAWPST-LYSRL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYfNFFGCVLPPLLIMLVIYVKIflvacrqlQRTELMdhsrtvlqreihaaKSLALIVGIFALCWLPVHTINCASLF- 258
Cdd:cd15001  167 YVVY-LAIVIFFIPLIVMTFAYARD--------TRKQVI--------------KMLISVVVLFAVCWGPLLIDNLLVSFd 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 121957962 259 --QPTWAKVKPKWAINTAiLLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15001  224 viSTLHTQALKYMRIAFH-LLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
24-300 8.11e-21

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 90.61  E-value: 8.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--TISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15205   17 GNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLlqNISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGlTPFLgwndrkIATNCTEPGDAATNVS--CCLIRclFENVVPMS 179
Cdd:cd15205   97 ERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVG-SPML------FVQQLEVKYDFLYEKRhvCCLER--WYSPTQQK 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLPPLLIMLVIYVKIFL-------VACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTI 252
Cdd:cd15205  168 IYTTFILVILFLLPLTTMLFLYSRIGYelwikkrVGDASVLQTIHGIEMSKISRKKKRAVKMMVTVVLLFAVCWAPFHVV 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 253 ---NCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15205  248 hmmIEYSNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
21-300 9.58e-21

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 90.28  E-value: 9.58e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQ-TPTNYFLVSLAAAD-VAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15099   14 TFLENILVLLTILSSTALRrRPSYLFIGSLALADmLASVIFTISFLDFHVFHQRDSRNLFLFKLGGVTMAFTASVGSLLL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEpgdaatnvscclircLFEnVVPM 178
Cdd:cd15099   94 TALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGWRCKTWDSPCSR---------------LFP-YIDR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLPPLLIMLVIYV------KIFLVACRQLQRTELMDHSRtvLQREIHAAKSLALIVGIFALCWLPVHTI 252
Cdd:cd15099  158 HYLASWTGLQLVLLFLIIYAYPYIlwkahrHEANMGGPKLGRQQVKGQAR--MRMDIRLAKTLSLILLVLAICWLPVLAF 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 253 NCASLFQPTWAKVKPKWAINTAILLshANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15099  236 MLVDVRVTLTNKQKRMFAFCSMLCL--VNSCVNPIIYALRSRELRGAM 281
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
24-300 3.99e-20

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 88.51  E-value: 3.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTislGFCTDF-----HSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15096   17 GNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTAT---DYVLPTwpfgdVWCKIVQYLVYVTAYASVYTLVL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIatnctepGDAATNVSccliRCLFENVVPM 178
Cdd:cd15096   94 MSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSY-------GFSSEAYS----YCTFLTEVGT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVY---FNFFGCVLPPLLIMlVIYVkifLVACR-QLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINC 254
Cdd:cd15096  163 AAQTFftsFFLFSYLIPLTLIC-VLYM---LMLRRlRRQKSPGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 255 ASLFQptwakVKP--KWAINTAIL---LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15096  239 LKYYG-----VLPetVLYVVIQILsncLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
21-300 4.00e-20

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 88.26  E-value: 4.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG---------FCTDFHSCLFLACFVlvltqs 91
Cdd:cd15302   14 TVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNgdywplgwvLCDLWLSVDYTVCLV------ 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDaatnvscCLIRCL 171
Cdd:cd15302   88 SIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQGRSLPEGE-------CYVQFM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 FENVVPMS-YMVYFnffgcvLPPLLIMLVIYVKIFLVACRQLQrtelmdhsrtvlqreihAAKSLALIVGIFALCWLPVH 250
Cdd:cd15302  161 TDPYFNMGmYIGYY------WTTLIVMLILYAGIYRAANRARK-----------------ALRTITFILGAFVICWTPYH 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 251 TINCASLFQPTWAKVkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15302  218 ILATIYGFCEAPPCV-NETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
22-300 4.09e-20

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 88.74  E-value: 4.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT---ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15133   15 VVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYelwQNYPFLLGSGGCYFKTFLFETVCLASILNVTA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgigLTPFLGWNDRKIATNCTEPGDAATnvsCCLIRCLF-ENVVP 177
Cdd:cd15133   95 LSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSM---LCALPNTSLHGIKFLGSGVPASAQ---CTVRKPQAiYNMIP 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFgcvlpPLLIMLVIYVKIFLVACRqlQRTELMDHSRTVLQREIHAA-----------KSLALIVGIFALCW 246
Cdd:cd15133  169 QHTGHLFFVL-----PMAVISVLYLLMALRLAR--ERGLDATGAGSKIGTRTGQLlqhprtraqvtKMLFILVVVFAICW 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121957962 247 LPVHTincASLFqptWAKVKpKWAINTAILLSHAN----------SAVNPIVYAYRNRDFRYTF 300
Cdd:cd15133  242 APFHI---DRLM---WSFIS-DWTDNLHEVFQYVHiisgvffylsSAVNPILYNLMSTRFREMF 298
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
25-297 4.81e-20

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 88.03  E-value: 4.81e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLgFCTDFhSCLFLACFVLVLTQSSIFSLLAVAVDRY 104
Cdd:cd15960   18 NAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYV-MNSEA-VTLCSAGLLLAAFSASVCSLLAITVDRY 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 105 LAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndrkiatNCTEpgdaaTNVSCCLIRCLFEN---VVPMSYM 181
Cdd:cd15960   96 LSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGW-------NCLR-----APASCSVLRPVTKNnaaVLAVSFL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFfgcvlpplliMLVIYVKIFLVACRQLQRTELMDH--SRTVLQREIHAAKSLALIVGIFALCWLPVHTIncASLFQ 259
Cdd:cd15960  164 LLFAL----------MMQLYLQICRIAFRHAQQIAVQHQfvNFCLASSTRKGVSTLSLILATFAFCWVPFAVY--SMVAD 231
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121957962 260 PTWakvkPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15960  232 SSY----PMIYTYYLVLPAACNSVINPIIYAFRNPDIQ 265
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
21-300 6.13e-20

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 87.93  E-value: 6.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL---GFCTDFHSCL------FLACFVLVLTqS 91
Cdd:cd15103   14 SLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILlnnGYLVPRDSFEqhidnvIDSMICSSLL-A 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTpFLGWNDRKIatnctepgdaatnVSCCLIRCL 171
Cdd:cd15103   93 SICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGIL-FIIYSDSVP-------------VIICLISMF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 FENvvpmsymvyfnffgcvlppLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQR-EIHAAKSLALIVGIFALCWLP-- 248
Cdd:cd15103  159 FAM-------------------LVLMASLYVHMFLLARSHVKKIAALPGQRSTRQRaNMKGAVTLTILLGVFIFCWAPff 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 249 ---VHTINCASlfQPTWAKVKPKWaiNTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15103  220 lhlTLMISCPS--NPYCACYMSHF--NVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
22-300 6.14e-20

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 88.16  E-value: 6.14e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG-----FCTDFhsCLFLACFVLVLTQSSIFSL 96
Cdd:cd15134   15 VVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQqypwvFGEVF--CKLRAFLSEMSSYASVLTI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVV 176
Cdd:cd15134   93 TAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAL-PFAIQTRIVYLEYPPTSGEALEESAFCAMLNEIPPIT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGCvlpPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVLQREIHAAKS-------LALIVGIFALCWLPV 249
Cdd:cd15134  172 PVFQLSTFLFFII---PMIAIIVLYVLIGL----QLRRSTLLRRGQRSVSGGRRSSQSrrtvlrmLVAVVVAFFICWAPF 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 250 HTINCASLFQPTWAkvKPKWAINTAIL-----LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15134  245 HAQRLLTVYAKNMT--PPYLFINRILFyisgvLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
22-300 3.02e-19

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 86.15  E-value: 3.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLvCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFA---VTISLGFCTDFHSCLFLACFVLVLTQ----SSIF 94
Cdd:cd14978   15 IIGNIL-NLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFllpYIADYSSSFLSYFYAYFLPYIYPLANtfqtASVW 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  95 SLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwnDRKIATNCTEPGDaaTNVSCCLIRCLFEN 174
Cdd:cd14978   94 LTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFF---EYEVVECENCNNN--SYYYVIPTLLRQNE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 175 VVPMSYMVYFNFFGCVLPPLLIMLVIYVKIfLVACRQLQRTELMDHSRTVL-----QREIHAAKSLALIVGIFALCWLPV 249
Cdd:cd14978  169 TYLLKYYFWLYAIFVVLLPFILLLILNILL-IRALRKSKKRRRLLRRRRRLlsrsqRRERRTTIMLIAVVIVFLICNLPA 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 250 HTIN-CASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14978  248 GILNiLEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
24-297 3.64e-19

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 85.57  E-value: 3.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCL-FLACFVLVLT-QSSIFSLLAVAV 101
Cdd:cd15012   16 GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLcRMYQFVHSLSyTASIGILVVISV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIatncTEPGDAATNVSCCLIRCLFEnvvpMSYM 181
Cdd:cd15012   96 ERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEI----LVTQDGQEEEICVLDREMFN----SKLY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFFGCVLPPLLIMLVIYVKIFLVacrqlqrtelMDHSRTVLQREiHAAKSLALIVGIFALCWLPVHTINCASLFQPT 261
Cdd:cd15012  168 DTINFIVWYLIPLLIMTVLYSKISIV----------LWKSSSIEARR-KVVRLLVAVVVSFALCNLPYHARKMWQYWSEP 236
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121957962 262 WAKVKPKWAINTAI--LLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15012  237 YRCDSNWNALLTPLtfLVLYFNSAVNPLLYAFLSKRFR 274
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
21-297 4.04e-19

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 85.79  E-value: 4.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLV-CAAVGTSSALQtPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDF--HSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15074   14 STLGNGTVlFVLYRRRSKLK-PAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFgdIGCVFYGFCGFLFGCCSINTLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPlRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRkiatnctepGDAATNVSCCLIRCLFENVVP 177
Cdd:cd15074   93 AISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSY---------GPEPFGTSCSIDWTGASASVG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 -MSYmVYFNFFGCVLPPLLIMLVIYVKIFL-VACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd15074  163 gMSY-IISIFIFCYLLPVLIIVFSYVKIIRkVKSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSMW 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 256 SLFQPTwAKVKPKWAInTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15074  242 SAFGSP-DSVPILASI-LPALFAKSSCMYNPIIYLLFSSKFR 281
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
21-300 9.22e-19

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 84.47  E-value: 9.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG----FCTDFhsCLFLACFVLVLTQSSIFSL 96
Cdd:cd15054   14 TVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYgrwvLARDF--CPIWYAFDVMCCSASILNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPF-LGWNDRKIA---TNCTEPGDAATnvscCLIRCLF 172
Cdd:cd15054   92 CVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIeLGWHELGHErtlPNLTSGTVEGQ----CRLLVSL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYFnffgcvlPPLLIMLVIYVKIFLVACRQLQrtelmdhsrtvlqreihAAKSLALIVGIFALCWLPVHTI 252
Cdd:cd15054  168 PYALVASCLTFF-------LPSGAICFTYCRILLAARKALK-----------------ASLTLGILLGMFFVTWLPFFVA 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 253 NCAslfQPTWAKVKPKwAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15054  224 NVV---QAVCDCVSPG-LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
22-300 1.03e-18

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 84.36  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAI-PFAVTISLGFCTDFH---SCLFLACFVLVLTQSSIFSLL 97
Cdd:cd14995   15 IVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGlPNEIESLLGPDSWIYgyaGCLLITYLQYLGINASSLSIT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWNDRKIAtncTEPGDAATNVSCCLIRCLFENVvp 177
Cdd:cd14995   95 AFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTS-LYCSPWLFLLDLSIK---HYGDDIVVRCGYKVSRHYYLPI-- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 msYMVYFNFFGCVlpPLLIMLVIYVKIflvacrqlqrtelmdhSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd14995  169 --YLADFVLFYVI--PLLLAIVLYGLI----------------GRILFSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNS 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 121957962 258 F-QPTWAkvkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14995  229 FaSPPYL---DLWFLLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
21-311 1.45e-18

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 83.84  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP-FAVTISLG-FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15299   17 TIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNlFTTYIIMNrWALGNLACDLWLSIDYVASNASVMNLLV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndRKIATNCTEPGDAatnvscCLIRCLFENVVPM 178
Cdd:cd15299   97 ISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFW--QYFVGKRTVPPDE------CFIQFLSEPIITF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFgcvlpPLLIMLVIYVKIFlvacrqlqrtelmdhSRTVlqREIHAAKSLALIVGIFALCWLPVhtiNCASLF 258
Cdd:cd15299  169 GTAIAAFYL-----PVTIMTILYWRIY---------------KETI--KEKKAAQTLSAILLAFIITWTPY---NIMVLV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 121957962 259 QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKIisryILCR 311
Cdd:cd15299  224 NTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKML----LLCQ 272
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
25-295 1.54e-18

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 83.78  E-value: 1.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIpfaVTISLGFCTDFHSCLFLACFVLVLT-QSSIFSLLAVAVDR 103
Cdd:cd15963   18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLGLI---LHFAFVYCIQSAPVNLVTVGLLAPSfTASVSSLLAITIDR 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 104 YLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATnctepgdaatnvSCCLIRCLFENVVPMSYMVY 183
Cdd:cd15963   95 YLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVVGWNCLKDPS------------TCSVVKPLTKNHLVILSISF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 184 FNFFGcvlppllIMLVIYVKIFLVACRQLQRTELMDH----SRTVLQREihAAKSLALIVGIFALCWLPVhTINCAsLFQ 259
Cdd:cd15963  163 FMVFA-------LMLQLYAQICRIVCRHAHQIALQRHflptSHYVTTRK--GIATLAVILGTFASCWLPF-AVYCL-LGD 231
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121957962 260 PTWakvkPKWAINTAILLSHANSAVNPIVYAYRNRD 295
Cdd:cd15963  232 YTY----PALYTYATLLPATYNSMINPIIYAFRNQE 263
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
25-301 2.04e-18

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 83.46  E-value: 2.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV------TISLG--FCTDFHSCLFLACfvlvltQSSIFSL 96
Cdd:cd15334   18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSImyivkeTWIMGqvVCDIWLSVDITCC------TCSILHL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgWndRKIATNCTEPgdaatnvscCLIRclFENVV 176
Cdd:cd15334   92 SAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF-W--RHQTTSREDE---------CIIK--HDHIV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYmvyfNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLP-----VHT 251
Cdd:cd15334  158 FTIY----STFGAFYIPLALILILYYKIYRAA-----------------TRERKAATTLGLILGAFVICWLPffvkeVIV 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 252 INCASLFQPTWAKVKPKWaintailLSHANSAVNPIVYAYRNRDFRYTFH 301
Cdd:cd15334  217 NTCDSCYISEEMSNFLTW-------LGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
21-300 2.19e-18

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 83.15  E-value: 2.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT-ISLG-FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15300   14 TIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSyILMGyWALGSLACDLWLALDYVASNASVMNLLV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndRKIATNCTEPGDAatnvscCLIRCLFENVVPM 178
Cdd:cd15300   94 ISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCW--QYFVGKRTVPERE------CQIQFLSEPTITF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFgcvlpPLLIMLVIYVKIFlvacrqlqrtelmdhSRTVLQREihAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15300  166 GTAIAAFYI-----PVSVMTILYCRIY---------------KETIKERK--AAQTLSAILLAFIITWTPYNIMVLVSTF 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 qptWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15300  224 ---CSDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
25-300 2.94e-18

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 83.15  E-value: 2.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIpfaVTISLGFCTDFHSCLFLACFVLVLTQS-SIFSLLAVAVDR 103
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLI---LNFIFAYLLQSEAAKLVTVGLIVASFSaSVCSLLAITVDR 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 104 YLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKiatnctepgDAATnvsCCLIRCLFENVVPMSYMVY 183
Cdd:cd15961   95 YLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLA---------DEST---CSVVRPLTKNNAAILSVSF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 184 FNFFGcvlppllIMLVIYVKIFLVACRQLQRTELMDH----SRTVLQREihAAKSLALIVGIFALCWLPVhtincaSLFQ 259
Cdd:cd15961  163 LLMFA-------LMLQLYIQICKIVMRHAHQIALQHHflatSHYVTTRK--GVSTLAIILGTFAACWMPF------TLYS 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121957962 260 PTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15961  228 LIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
22-300 2.99e-18

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 83.37  E-value: 2.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT---ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15357   15 VIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYemwSNYPFLFGPVGCYFKTALFETVCFASILSVTT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLA--FGIGLTPFLGWNDRKIATNCTEPGDAatnvSCCLIRCL--FEN 174
Cdd:cd15357   95 VSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSvlFSIPNTSIHGIKLQYFPNGTLIPDSA----TCTVVKPLwiYNL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 175 VVPMSYMVYFnffgcVLPplliMLVIYVKIFLVACR-QLQRTELMDHSRTVLQREIHAA--KSLALIVGIFALCWLPVHT 251
Cdd:cd15357  171 IIQITSLLFY-----VLP----MGVISVLYYLMGLKlRGDKSLEADEMNVNIQRPSRKSvtKMLFVLVLVFAICWAPFHV 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 121957962 252 INCASLFQPTWAKVKPKwAINTAILLS----HANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15357  242 DRLFFSFVVEWTEPLAN-VFNLIHVVSgvffYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
22-248 3.25e-18

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 82.88  E-value: 3.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLfAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15905   13 IFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGV-ALPFIPGMSNESRRGYHSCLFVYVAPNFLFLSFLANLLMVHY 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTepgdaatnvscclirclFENVVPMSYm 181
Cdd:cd15905   92 ERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPALGWNNWTPGSNCS-----------------YKQVFPAAY- 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121957962 182 VYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDH-------SRTVLQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd15905  154 IYLEVYGLVLPSILAIAFMSVRVLAVARRQLQDICKLLRavqrdgpSELEQQLNLRYAKCIAGVSLTFLVCWVP 227
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
21-300 4.05e-18

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 82.54  E-value: 4.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--TISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15333   18 TTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIvyTVTGTWTLGQVVCDIWLSSDITCCTASILHLCV 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgWNDRKiatnctepgdAATNVSCCLIrclfeNVVPM 178
Cdd:cd15333   98 IALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF-WRQAK----------AEEEVSECVV-----NTDHI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYfNFFGCVLPPLLIMLVIYVKIFlVACRqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTINCaslf 258
Cdd:cd15333  162 LYTVY-STVGAFYIPTLLLIALYGRIY-VEAR---------------ARERKATKTLGIILGAFIVCWLPFFIISL---- 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 259 qpTWAKVKPKWAINTAIL-----LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15333  221 --VLPICKDACWFHLAIFdfftwLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
25-297 7.75e-18

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 82.19  E-value: 7.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSAL-QTPTNYFLVSLAAADV-AVGLFAIPFaVTISLGFCTDFHSCLFLACFVLVLT-QSSIFSLLAVAV 101
Cdd:cd15341   18 NVAVLYLILSSPKLrRKPSYLFIGSLALADFlASVVFACSF-VDFHVFHGVDSSAIFLLKLGGVTMSfTASLGSLLLMAF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEpgdaatnvscclircLFEnVVPMSYM 181
Cdd:cd15341   97 DRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLMGWNCCPLNSPCSE---------------LFP-LIPNDYL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFFGCVLPPLLIMLVIYV--KIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQ 259
Cdd:cd15341  161 LSWLLLVAILLSGIIYTYGHVlwKAHKHVVYMEKHQDQQGPGNARMRLDVRLAKTLGLVLAVLLICWSPVLALMMHSLFT 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121957962 260 PTWAKVKPKWAINTAILLshANSAVNPIVYAYRNRDFR 297
Cdd:cd15341  241 SLSDHIKKAFAFCSTLCL--VNSMVNPIIYALRSRELR 276
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
24-300 9.21e-18

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 82.12  E-value: 9.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP---FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd15358   17 GNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPlelYEMWSNYPFLLGAGGCYFKTLLFETVCFASILNVTALS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 101 VDRYLAVRVPLRYKSLVTGARARGVIAALWVLA--FGIGLTPFLGWNDRKIATNCTEPGDAatnvSCCLI--RCLFENVV 176
Cdd:cd15358   97 VERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSilCSIPNTSLHGIFQLTVPCRGPVPDSA----TCMLVkpRWMYNLII 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFnffgcvLPPLLIMLVIYVKIFLvacrQLQRTELM-------------DHSRTVLQREI---HAAKSLALIVG 240
Cdd:cd15358  173 QITTLLFF------FLPMGTISVLYLLIGL----QLKREKMLlvleakgskagdsYQHRRIQQEKRrrrQVTKMLFVLVV 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121957962 241 IFALCWLPVHTINCASLFQPTWAKVKPKWAINTAIL---LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15358  243 VFGICWAPFHTDRLMWSFISQWTGELHLAFQYVHIIsgvFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
21-300 1.15e-17

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 81.88  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQT-PTNYFLVSLAAADVavgLFAIPFAVTIslgfcTDFHSC---------LFLACFVLVLTQ 90
Cdd:cd15340   14 TVLENLLVLCVILHSRSLRCrPSYHFIGSLAVADL---LGSVIFVYSF-----LDFHVFhrkdspnvfLFKLGGVTASFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEpgdaatnvscclirc 170
Cdd:cd15340   86 ASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLLGWNCKKLNSVCSD--------------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 lfenVVPMSYMVYFNFFGCVlPPLLIMLVIYVKIFLV------ACRQLQRT---ELMDHSRT----------VLQREIHA 231
Cdd:cd15340  151 ----IFPLIDETYLMFWIGV-TSVLLLFIVYAYMYILwkahhhAVRMLQRGtqkSIIVYTSEdgkvqttrpdQTRMDIRL 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 232 AKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLshANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15340  226 AKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCL--LNSTVNPIIYALRSKDLRHAF 292
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
21-300 5.57e-17

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 79.60  E-value: 5.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL----------GFCTDFHSCL-FLACFVLVlt 89
Cdd:cd15354   14 SLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLlnnrhlviedAFVRHIDNVFdSLICISVV-- 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  90 qSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTpFLGWNDrkiatnctepgdaATNVSCCLIR 169
Cdd:cd15354   92 -ASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGII-FILYSE-------------STYVIICLIT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 CLFENvvpmsymvyfnffgcvlppLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQR-EIHAAKSLALIVGIFALCWLP 248
Cdd:cd15354  157 MFFAM-------------------LFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRtSMKGAVTLTILLGIFIVCWAP 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 249 --VHTINCASLFQPTWAkVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15354  218 ffLHLILMISCPQNLYC-VCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
25-300 6.46e-17

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 79.20  E-value: 6.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVD 102
Cdd:cd15335   18 NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITyiVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 103 RYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPfLGWNDRKIATNCTEpgdaatnvscCLIRclFENVVpmsYMV 182
Cdd:cd15335   98 RYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPP-LFWRNHHDANIPSQ----------CIIQ--HDHVI---YTI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 183 YfNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTINCasLFQPTW 262
Cdd:cd15335  162 Y-STFGAFYIPLTLILILYYRIYHAA-----------------SRERKAARILGLILGAFILSWLPFFIKEL--IVGLSV 221
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121957962 263 AKVKPKWAiNTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15335  222 MTVSPEVA-DFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
21-297 8.83e-17

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 78.56  E-value: 8.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15213   14 GFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVtiITGRWIFGDIFCRISAMLYWFFVLEGVAILLI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVrvpLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEpgdaatnvscclirCLFENVVPM 178
Cdd:cd15213   94 ISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQ--------------CVLGYTESP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVL--PPLLIMLVIYVKIFlvacrqlqrtelmdhsRTVLQREIHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15213  157 ADRIYVVLLLVAVffIPFLIMLYSYFCIL----------------NTVRSFKTRAFTTILILFIGFSVCWLPYTVYSLLS 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 257 LFQptwAKVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15213  221 VFS---RYSSSFYVISTCLLwLSYLKSAFNPVIYCWRIKKFR 259
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
22-300 9.02e-17

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 79.26  E-value: 9.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTislgfctDFHS----------CLFLACFVLVLTQS 91
Cdd:cd14997   15 VLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALV-------ETWArepwllgefmCKLVPFVELTVAHA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkIATNCTEPGDAATNVSCCLIRCL 171
Cdd:cd14997   88 SVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLF------ITEFKEEDFNDGTPVAVCRTPAD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 FENVVPMSYMVYFNFFGCvlpPLLIMLVIYVKIflvaCRQLQRTELMDHSRTvLQREIHAAKS-------LALIVGIFAL 244
Cdd:cd14997  162 TFWKVAYILSTIVVFFVV---PLAILSGLYSVI----CRRLVGHPALESRRA-DAANRHTLRSrrqvvymLITVVVLFFV 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121957962 245 CWLPVHTINCASLFQPTwAKVKPKWAINTAILLSHA------NSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14997  234 CLLPFRVVTLWIIFAPD-EDLQALGLEGYLNLLVFCrvmvylNSALNPILYNLMSTKFRSAF 294
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
21-300 9.78e-17

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 79.29  E-value: 9.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADvavglfaipFAVTISLGFCTDFHSCL-------FLACFVLVLTQS-- 91
Cdd:cd15337   14 GVIGNLLVIYLFSKTKSLRTPSNMFIINLAISD---------FGFSAVNGFPLKTISSFnkkwiwgKVACELYGFAGGif 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 ---SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdRKIA----TNCTEpgDAATNVS 164
Cdd:cd15337   85 gfmSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWG-RYVPegfqTSCTF--DYLSRDL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 165 CCLIRCLFenvvpmsyMVYFNFFGcvlpPLLIMLVIYVKIFLVACRQ----LQRTELMDHSRTVLQR-----EIHAAKSL 235
Cdd:cd15337  162 NNRLFILG--------LFIFGFLC----PLLIIIFCYVNIIRAVRNHekemTQTAKSGMGKDTEKNDarkkaEIRIAKVA 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 236 ALIVGIFALCWLPVHTINCASLFQPT-WakVKPkWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15337  230 IILISLFLLSWTPYAVVALLGQFGPAyW--ITP-YVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
22-297 1.49e-16

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 78.41  E-value: 1.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15402   15 ILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTsiFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLgwndrKIATNCTEPGdaatnvsccLIRCLFENVVPMS 179
Cdd:cd15402   95 AINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTV-AAIVPNL-----FVGSLQYDPR---------IYSCTFAQSVSSA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLpPLLIMLVIYVKIFLVACrQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQ 259
Cdd:cd15402  160 YTIAVVFFHFIL-PIIIVTFCYLRIWILVI-QVRRRVKPDNKPKLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLAVAVD 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 121957962 260 P-TWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15402  238 PeTIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFR 276
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
22-297 1.57e-16

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 78.11  E-value: 1.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVcAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd14974   15 LPGNGLV-IWVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSvlCKLNSFVISLNMFASVFLLTAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDrkiatncTEPGDAatNVSCCLIRCLFENVVPMS 179
Cdd:cd14974   94 SLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSV-PYFVFRD-------TVTHHN--GRSCNLTCVEDYDLRRSR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYF--NFFGCVLPPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVlqreihaaKSLALIVGIFALCWLPVHTIncaSL 257
Cdd:cd14974  164 HKALTviRFLCGFLLPLLIIAICYSVIAV----KLRRKRLAKSSKPL--------RVLLAVVVAFFLCWLPYHVF---AL 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 258 FQPTWAKVKPK---WAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd14974  229 LELVAAAGLPEvvlLGLPLATGLAYFNSCLNPILYVFMGQDFR 271
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
22-299 2.19e-16

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 78.22  E-value: 2.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLgfctdFHSCLF--LACFVLVLTQ-----SSIF 94
Cdd:cd15336   15 MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSL-----HKRWIFgeKGCELYAFCGalfgiTSMI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  95 SLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWND---RKIATNCTepGDAAT----NVSCCL 167
Cdd:cd15336   90 TLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAyvpEGLLTSCT--WDYMTftpsVRAYTM 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 IRCLFenvvpmsymVYFnffgcvlPPLLIMLVIYVKIFLV---ACRQLQRTELMDHSRTVLQR-----EIHAAKSLALIV 239
Cdd:cd15336  168 LLFCF---------VFF-------IPLGIIIYCYLFIFLAirsTGREVQKLGSQDRKEKAKQYqrmknEWKMAKIAFVVI 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 240 GIFALCWLPVHTIncASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYT 299
Cdd:cd15336  232 LLFVLSWSPYACV--ALIAWAGYAHLLTPYMKSVPAVIAKASAIYNPIIYAITHPKYREA 289
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
22-303 2.27e-16

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 77.56  E-value: 2.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15295   15 VLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRglCVFWLVIDYLLCTASVYNIVLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTG-ARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGdAATNVSCCLIRCLFENVVPM 178
Cdd:cd15295   95 SYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGECEPE-FFSNWYILAITSVLEFLVPV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFgcvlppllimlvIYVKIflvacrqlqrtelmdHSRTvlqREIHAAKSLALIVGIFALCWLPVhtiNCASLF 258
Cdd:cd15295  174 ILVAYFNTQ------------IYWSL---------------WKRL---RDRKLAKSLAIILGTFAICWAPY---SLFTII 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 259 QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKI 303
Cdd:cd15295  221 RAACEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKI 265
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
25-300 2.40e-16

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 77.92  E-value: 2.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLfAIPFAVtislgfctdFHS---CLFLACFVLVLTQS--------SI 93
Cdd:cd15342   18 NLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGV-AYLFLM---------FHTgpwTAKLSLYQWFLRQGlldtsltaSV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVrVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndrkiatNCTepgdaatnvsCCLIRClfE 173
Cdd:cd15342   88 ANLLAIAVERHQTI-FTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGW-------NCL----------CDLKRC--S 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVVPMSYMVYFNFFGCV-LPPLLIMLVIYVKIFLVACRQLQRTElMDHSRTVLQRE--IHAAKSLALIVGIFALCWLP-- 248
Cdd:cd15342  148 TMAPLYSRSYLVFWALSnLLTFLIMVAVYTRIFIYVRRKSQRMS-EHHSSHPRYREtvLGLMKTVVIILGAFVVCWTPgq 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 249 ----VHTINCASLFQPTWAKVkpkwaintAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15342  227 vvllLDGLGCESCNVLAYEKY--------FLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
40-300 2.62e-16

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 77.69  E-value: 2.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  40 TPTNYFLVSLAAADVAVGLfAIPFAVTISLG-----FCTDFhsCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYK 114
Cdd:cd14982   33 SPTTIYMINLALADLLFVL-TLPFRIYYYLNggwwpFGDFL--CRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSR 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 115 SLVTGARARGVIAALWVLAFGIGLtPFLgWNDRKIATNCTEpgdaatnvscclIRCLFENVVPMSYMVYFNFFGCV---L 191
Cdd:cd14982  110 RLRRKRYAVGVCAGVWILVLVASV-PLL-LLRSTIAKENNS------------TTCFEFLSEWLASAAPIVLIALVvgfL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 192 PPLLIMLVIYVKIflvaCRQLQRTELMDHSRTVLQReihAAKSLALIVGIFALCWLPVHtincasLFQPTWAKVKPKWAI 271
Cdd:cd14982  176 IPLLIILVCYSLI----IRALRRRSKQSQKSVRKRK---ALRMILIVLAVFLVCFLPYH------VTRILYLLVRLSFIA 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121957962 272 NTA------------ILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14982  243 DCSarnslykayritLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
24-300 5.11e-16

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 76.79  E-value: 5.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTS-SALQTPTNYFLVSLAAADVAVGLFAIPFAVTI-SL-GFCTDFHSCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd15097   17 GNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILFCVPFQATIySLeGWVFGSFLCKAVHFFIYLTMYASSFTLAAVS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 101 VDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWND--RKIATNCTEPGDAATNVScCLIRCLFenvvpm 178
Cdd:cd15097   97 VDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSL-LFAGPYLSYYDliDYANSTVCMPGWEEARRK-AMDTCTF------ 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 symvyfnFFGCVLPPLLIMLViYVKIFLVACRQLQRTELMDHSRTVLQReihAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15097  169 -------AFGYLIPVLVVSLS-YTRTIKYLWTAVDPLEAMSESKRAKRK---VTKMIIIVTALFCLCWLPHHVVILCYLY 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 259 QptwakvkpKWAINTAI----LLSH----ANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15097  238 G--------DFPFNQATyafrLLSHcmayANSCLNPIVYALVSKHFRKGF 279
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
8-300 7.93e-16

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 76.42  E-value: 7.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG----FCTDFhsCLFLAC 83
Cdd:cd16004    1 ALWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHndwyFGLEF--CRFQNF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  84 FVLVLTQSSIFSLLAVAVDRYLAVRVPLryKSLVTGARARGVIAALWVLAFGIGLTP--FLGWNDRKIATNCTE--PGDA 159
Cdd:cd16004   79 FPITAMFVSIYSMTAIAADRYMAIIHPF--KPRLSAGSTKVVIAGIWLVALALAFPQcfYSTVTMDQGRTKCIVawPGDS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 160 ATNVsccliRCLFENVVPMsyMVYfnffgcvLPPLLIMLVIYVKIFL-VACRQLQRTELMDHSRTVLQREIHAAKSLALI 238
Cdd:cd16004  157 GGKH-----QLTYHLAVIV--LIY-------LLPLAVMFVTYSIIGItLWRSAVPGHQAHGAYHRQLQAKKKFVKTMVVV 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121957962 239 VGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAI-LLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd16004  223 VVTFAICWLPYHLYFILGSFNEDIYCQKYIQQVYLAIfWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
21-300 1.25e-15

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 75.39  E-value: 1.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP-FAVTISLGFCT-DFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15297   14 TIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNlYTLYTVIGYWPlGPVVCDLWLALDYVVSNASVMNLLI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndRKIATNCTEPGDAatnvscCLIRcLFENVVpm 178
Cdd:cd15297   94 ISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFW--QFIVGGRTVPEGE------CYIQ-FFSNAA-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 syMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTelmdhsRTVlqreihaaksLALIVGiFALCWLPVhtiNCASLF 258
Cdd:cd15297  163 --VTFGTAIAAFYLPVIIMTVLYWQISRASSREKKVT------RTI----------LAILLA-FIITWTPY---NVMVLI 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15297  221 NTFCASCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
24-300 1.50e-15

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 75.59  E-value: 1.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADvAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQS--SIFSLLAVAV 101
Cdd:cd15094   17 GNGLVIYVVLRYAKMKTVTNLYILNLAVAD-ECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQftSSFTLTVMSA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkiatnCTEPGDAATNVSCCLIRCLFENVVPMSYM 181
Cdd:cd15094   96 DRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIIL----------YASTVPDSGRYSCTIVWPDSSAVNGQKAF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFFGCVLPPLLIMLVIYVKIFlvacRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPT 261
Cdd:cd15094  166 TLYTFLLGFAIPLLLISVFYTLVI----LRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPP 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 262 WAKVkPKWAINTAIL---LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15094  242 GTDM-PKWEILMFLLltvLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
21-300 2.13e-15

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 74.94  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQ-------SSI 93
Cdd:cd15353   14 SLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQSFTVNIDNVIDSvicssllASI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTpFLGWNDrkiatnctepgdaATNVSCCLIRCLFE 173
Cdd:cd15353   94 CSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVL-FIIYSD-------------SSVVIICLISMFFT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NvvpmsymvyfnffgcvlppLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQ-REIHAAKSLALIVGIFALCWLP--VH 250
Cdd:cd15353  160 M-------------------LALMASLYVHMFLLARLHIKRIAVLPGTGPIRQgANMKGAITLTILLGVFVVCWAPffLH 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 251 TINCASLFQPTWAkVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15353  221 LIFYISCPRNPYC-VCFMSHFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
22-300 2.50e-15

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 74.81  E-value: 2.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGlfaIPFAVTISLGFCTDFH---SCLFL-ACFVLVLTQSSIFSLL 97
Cdd:cd15102   15 VLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAG---AAYLANILLSGARTLRlspAQWFLrEGSMFVALSASVFSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGaRARGVIAALWVLAFGIGLTPFLGWNdrkiatnCTepgdaatnvsCCLIRClfENVVP 177
Cdd:cd15102   92 AIAIERHLTMAKMKPYGASKTS-RVLLLIGACWLISLLLGGLPILGWN-------CL----------GALDAC--STVLP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFfgCVLPPLLIMLVI---YVKIF-LVACRQLQRTELMDHSRTVlqreiHAAKSLALIVGIFALCWLPVHTIN 253
Cdd:cd15102  152 LYSKHYVLF--CVTIFAGILAAIvalYARIYcLVRASGRKATRASASPRSL-----ALLKTVLIVLLVFIACWGPLFILL 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 254 CASLFQPTWAK---VKPKWAINTAILlshaNSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15102  225 LLDVACPVKTCpilYKADWFLALAVL----NSALNPIIYTLRSRELRRAV 270
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
25-300 8.29e-15

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 73.32  E-value: 8.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGL--FAIPF---AVTISLGFCTDFhscLFLACFVLVLTqSSIFSLLAV 99
Cdd:cd15101   18 NLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLayFFLMFntgPNTRRLTVSTWF---LRQGLLDTSLT-ASVANLLAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVrVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdrkiatnCTEPGDAATNVSCCLIRclfenvvpmS 179
Cdd:cd15101   94 AVERHISV-MRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGWN-------CLCAIDACSNMAPLYSR---------S 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLppLLIMLVIYVKIFLVACRQLQRTElmDHSRTVLQRE---IHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15101  157 YLVFWAISNLVT--FLVMVVVYARIFVYVRRRTNRMS--PHTSGSIRNRdtmMSLLKTVVIVLGAFVVCWTPGLVVLLLD 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 257 LFQPTWAKVK--PKWAIntaiLLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15101  233 GLCCRQCNVLavEKFFL----LLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
21-300 9.50e-15

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 73.13  E-value: 9.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP-FAVTISLGFCT-DFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15298   14 TVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNlYTVYIIKGYWPlGAVVCDLWLALDYVVSNASVMNLLI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdRKIATNCTEPGDaatnvscCLIRCLFENVVPM 178
Cdd:cd15298   94 ISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQ-FVVGKRTVPDNQ-------CFIQFLSNPAVTF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFgcvlpPLLIMLVIYVKIFLVACRQLQRTelmdhsrtvlqreihaaKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15298  166 GTAIAAFYL-----PVVIMTVLYIHISLASARERKVT-----------------RTIFAILLAFILTWTPYNVMVLVNTF 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAkvkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15298  224 CQSCI---PDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
21-297 1.07e-14

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 73.23  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15073   14 STISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLhgSWKFGYAGCQWYAFLNIFFGMASIGLLTV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAV-RVPLRYKslVTGARARGVIAALWVLAFGIGLTPFLGWndrkiATNCTEPGDAAtnvscCLIRCLFENVVP 177
Cdd:cd15073   94 VAVDRYLTIcRPDLGRK--MTTNTYTVMILLAWTNAFFWAAMPLVGW-----ASYALDPTGAT-----CTINWRKNDSSF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYmVYFNFFGCVLPPLLIMLVIYVKIFLvACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPvHTINC--A 255
Cdd:cd15073  162 VSY-TMSVIVVNFIVPLAVMFYCYYNVSR-FVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSP-YSIVClwA 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 256 SLFQPtwAKVKPKWAInTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15073  239 SFGEP--KKIPPWMAI-IPPLFAKSSTFYNPCIYVIANKKFR 277
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
91-297 2.15e-14

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 72.12  E-value: 2.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndrkiatnctepgdaatNVSCCLIRC 170
Cdd:cd15349   85 ASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGW-----------------NCLCDFRSC 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 lfENVVPMsYMVYFNFFGCVL--PPLLIMLVIYVKIFLVACRQLQRTeLMDHSRtvlQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd15349  148 --SSLLPL-YSKSYILFCLVIffIILLTIIGLYFAIYCLVRASGQRV-ISARSR---RRSLRLLKTVLMILGAFMVCWGP 220
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 249 VHTINCASLFQPTWAKVKPK---WAINTAILlshaNSAVNPIVYAYRNRDFR 297
Cdd:cd15349  221 LFILLLVDFFCSSRSCKPLFgmeWVLALAVL----NSAINPLIYSFRSLEVR 268
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
21-300 3.14e-14

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 71.89  E-value: 3.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLF--AIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd16003   14 AVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFntLINFIYALHSEWYFGEAYCRFHNFFPITSVFASIYSMTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLryKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNCTE-----PGDAATNVSCCLIrclfe 173
Cdd:cd16003   94 IAVDRYMAIIDPL--KPRLSATATKVVIGSIWILAFLLAF-PQCLYSKTKVMPGRTLcfvawPGGPDQHFTYHII----- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 nVVPMSYMVyfnffgcvlpPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTIN 253
Cdd:cd16003  166 -VIVLVYCL----------PLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYF 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 254 CASLFQPTWAKVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd16003  235 IVTGLYQQLNRWKYIQQVYLASFwLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
21-299 3.52e-14

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 71.36  E-value: 3.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVG---LFAIPFAVTISLGFCTDFHSCL-FLACFVLVLTQSSIFSL 96
Cdd:cd15351   14 SLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSvsnLIETLFMLLLEHGVLVCRAPMLqHMDNVIDTMICSSVVSS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 L----AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVlafgigltpflgwndrkiatnctepgdAATNVSCCLIRCLF 172
Cdd:cd15351   94 LsflgAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWL---------------------------ASTVSSTLFIVYYN 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYFNFFgcvlppLLIMLVIYVKIFLVACRQLQR-TELMDHSRTVLQ-REIHAAKSLALIVGIFALCWLP-- 248
Cdd:cd15351  147 SNAVILCLIVFFLFM------LVLMLVLYIHMFILACRHSQSiSSQQRRQCPHQQtASLKGAITLTILLGIFFLCWGPff 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 249 VHTINCASLFQPTWAKVKPKWaINTAILLSHANSAVNPIVYAYRNRDFRYT 299
Cdd:cd15351  221 LHLTLIVTCPTHPFCLCYFKY-FNLFLILIICNSIIDPLIYAFRSQELRKT 270
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
21-300 4.47e-14

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 71.43  E-value: 4.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLF--AIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd16002   14 SVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFntVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARArgVIAALWVLAFGIGLTPFLgwndrkIATNCTEPGdaatNVSCCLIRCLFENVVPM 178
Cdd:cd16002   94 IALDRYMAIIHPLQPRLSATATKV--VICVIWVLAFLLAFPQGY------YSDTEEMPG----RVVCYVEWPEHEERKYE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd16002  162 TVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYF 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 259 QPTWAKVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd16002  242 HPELYEQKFIQQVYLAIMwLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
25-300 4.85e-14

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 70.75  E-value: 4.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG---FCTDFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15328   18 NLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSgrrWQLGRSLCQVWISFDVLCCTASIWNVTAIAL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYkSLVTGARARGVIAAL-WVLAFGIGLTPFL-GWNDrkiatnCTEPGDAATNVScclirclfenvVPMS 179
Cdd:cd15328   98 DRYWSITRHLEY-TLRTRRRISNVMIALtWALSAVISLAPLLfGWGE------TYSEDSEECQVS-----------QEPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVyFNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTIN-----C 254
Cdd:cd15328  160 YTV-FSTFGAFYLPLCVVLFVYWKIYKAA-----------------QKEKRAALMVGILIGVFVLCWIPFFLTElisplC 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 255 ASLFQPTWAKVkpkwaintAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15328  222 SCDIPPIWKSI--------FLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
21-300 5.20e-14

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 70.97  E-value: 5.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL---GFCT----------DFHSCLFLACFVlv 87
Cdd:cd15350   14 GLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILadmGYLNrrgpfetkldDIMDSLFCLSLL-- 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  88 ltqSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtpflgwndrkiatnctepgdaatnvsccL 167
Cdd:cd15350   92 ---GSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGI----------------------------L 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 IRCLFENVVPMSYMVYFNFFGcvlppLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQRE-IHAAKSLALIVGIFALCW 246
Cdd:cd15350  141 MILFFHFVATVICFTVLFFLM-----LVLILCLYVHMFLLARSHARKIASLPNHHAQHQRSnMRGAITLTILLGVFVCCW 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 247 LPV-----------HTINCA---SLFQptwakvkpkwaINTAILLSHAnsAVNPIVYAYRNRDFRYTF 300
Cdd:cd15350  216 APFvlhlllmmfcpMNPYCAcyrSLFQ-----------VNGTLIMSHA--VIDPAIYAFRSPELRNTF 270
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
22-300 5.64e-14

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 71.14  E-value: 5.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLfAIPFAVTISLGFCTDFHSCLflaCFVLVLTQ-----SSIFSL 96
Cdd:cd15091   15 LVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVL---CKIVISIDyynmfTSIFTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPF-LGWNDRKIATNCTEpgdaatnvsCCLIRCLFENV 175
Cdd:cd15091   91 TMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIvLGGTKVREDVDSTE---------CSLQFPDDDYS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd15091  162 WWDTFMKICVFIFAFVIPVLIIIVCYTLMIL----RLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 256 SLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15091  238 EALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
21-293 6.04e-14

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 70.92  E-value: 6.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAAD---VAVGLFAIPFAVTISLGFCTDFHsCLFLACFVLVLTQSSIFSLL 97
Cdd:cd14964   12 GLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDllaSLVVLVLFFLLGLTEASSRPQAL-CYLIYLLWYGANLASIWTTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEpgdaatnvSCCLIrclFENVVp 177
Cdd:cd14964   91 VLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTG--------SCYLI---CTTIY- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 msYMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRTELMDHSRTvlQREIHAAKSLALIVGIFALCWLP--VHTINCA 255
Cdd:cd14964  159 --LTWGFLLVSFLL-PLVAFLVIFSRIVLRLRRRVRAIRSAASLNT--DKNLKATKSLLILVITFLLCWLPfsIVFILHA 233
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121957962 256 SLFQPTwakvKPKWAINTAILLSHANSAVNPIVYAYRN 293
Cdd:cd14964  234 LVAAGQ----GLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
23-297 6.97e-14

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 70.55  E-value: 6.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  23 TGNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPF-AVTISLGFCTDFHSCLF-LACFVLVLTQ-SSIFSLLAV 99
Cdd:cd15193   16 LGNLFVIALMSKRSTTKRLVDTFVLNLAVADL-VFVLTLPFwAASTALGGQWLFGEGLCkLSSFIIAVNRcSSILFLTGM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNCTEPGDAATNVSCCLIrclfenvvpms 179
Cdd:cd15193   95 SVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGI-PSLVYRNLINESVCVEDSSSRFFQGISLA----------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 yMVYFNFfgcvLPPLLIMLVIYVKIFlvacRQLQRTelMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQ 259
Cdd:cd15193  163 -TLFLTF----VLPLIVILFCYCSIL----VRLRRH--FHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 260 PTWAKVKP-------KWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15193  232 ELGGGVLPchttvaiRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
8-300 7.77e-14

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 70.69  E-value: 7.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--TISLGFCTDFHSCLFLACFV 85
Cdd:cd15980    1 AVFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLldNIIAGWPFGSTVCKMSGMVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  86 LVLTQSSIFSLLAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIgLTP---FLGWNDRKIATNCTEPGDAATN 162
Cdd:cd15980   81 GISVSASVFTLVAIAVDRFRCIVYPFKQK--LTISTAVVIIVIIWVLAIAI-MCPsavMLHVQEEKNYRVVLGSQNKTSP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 163 VSCCliRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSR---TVLQREIHAAKSLALIV 239
Cdd:cd15980  158 VYWC--REDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEqrhVVSRKKQKVIKMLLIVA 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 240 GIFALCWLPVHTIncasLFQPTWAKVKPK--WAINTAIL-----LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15980  236 LLFILSWLPLWTL----MMLSDYANLSPNqlQIINIYIYpfahwLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
21-300 1.06e-13

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 70.30  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAV----GLFAIPFAV------TISLGFCTDFHS-CLFLACFVLVlt 89
Cdd:cd15352   14 SLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVsvsnSLETIMIAVlnsgylVISDQFIQHMDNvFDSMICISLV-- 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  90 qSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTpFLGWNDRKIatnctepgdaatnVSCCLIR 169
Cdd:cd15352   92 -ASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIV-FIVYSESKT-------------VIVCLIT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 CLFENvvpmsymvyfnffgcvlppLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQRE---IHAAKSLALIVGIFALCW 246
Cdd:cd15352  157 MFFAM-------------------LVLMATLYVHMFLFARLHVKRIAALPPAVDGAPQQrscMKGAVTITILLGVFIVCW 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 247 LP-----VHTINCASLFQPtwakVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15352  218 APfflhlILIISCPHNPYC----LCYTSHFNTYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
21-290 1.24e-13

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 70.30  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT-ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15079   14 SLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNsFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLvTGARARGVIAALWVLAFGIGLTPFL-GWNdrkiatNCTEPGdaatNVSCCLIRCLFENVVPM 178
Cdd:cd15079   94 AYDRYNVIVKPLNGNPL-TRGKALLLILFIWLYALPWALLPLLfGWG------RYVPEG----FLTSCSFDYLTRDWNTR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFnFFGCVLPPLLIMLVIYVKIFLVAC----------RQLQRTELMDHSRTVLQR-EIHAAKSLALIVGIFALCWL 247
Cdd:cd15079  163 SFVATI-FVFAYVIPLIIIIYCYSFIVKAVFahekalreqaKKMNVVSLRSNADANKQSaEIRIAKVALTNVFLWFIAWT 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 248 PVHTINCASLFQPTwAKVKPkwaINTAI--LLSHANSAVNPIVYA 290
Cdd:cd15079  242 PYAVVALIGAFGNQ-SLLTP---LVSMIpaLFAKTAACYNPIVYA 282
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
22-297 1.91e-13

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 69.55  E-value: 1.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15401   15 VLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFhnGWTLGNIHCQISGFLMGLSVIGSVFNITAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPF----LGWNDRkiatnctepgdaatnvsccLIRCLFENV 175
Cdd:cd15401   95 AINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFfvgsLQYDPR-------------------IYSCTFAQT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRTElMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd15401  156 VSSSYTITVVVVHFIV-PLSIVTFCYLRIWVLVIQVKHRVR-QDSKQKLKANDIRNFLTMFVVFVLFAVCWGPLNFIGLA 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 256 SLFQPTWAKVK-PKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15401  234 VAINPLKVAPKiPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFR 276
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
24-297 3.98e-13

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 68.72  E-value: 3.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPF-AVTISLG---FCTDFHSCLFLACFVLVLTQSSIfsLLAV 99
Cdd:cd15403   17 GNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFtAVTIITVdwhFGAHFCRISAMLYWFFVLEGVAI--LLII 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVrvpLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTE--------PGDAATNVSccLIRCL 171
Cdd:cd15403   95 SVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARAPQcvlgytesPADRVYAVL--LVVAV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 FenVVPMSYMVYfnFFGCVLPPLLIMLV-IYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKS------LALIVGiFAL 244
Cdd:cd15403  170 F--FVPFSIMLY--SYLCILNTVRRNAVrIHNHADSLCLSQVSKLGLMGLQRPHQMNVDMSFKTrafttiLILFVG-FSL 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 245 CWLPVHTINCASLFQPTWAKVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15403  245 CWLPHTVFSLLSVFSRRFYYSSSFYPISTCVLwLSYLKSVFNPVIYCWRIKKFR 298
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
22-298 5.11e-13

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 68.29  E-value: 5.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAV---------TISLGFCTDFHscLFLACFvlvlTQSS 92
Cdd:cd15928   15 ASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-FLVLPLDLyrlwryrpwRFGDLLCRLMY--FFSETC----TYAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLgwndrKIATNCTEPGDAATNVSCCLIRCLF 172
Cdd:cd15928   88 ILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAI-VSAGPAL-----VLVGVEHIQGQQTPRGFECTVVNVS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYFNFFgcvLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREiHAAKSLALIVGIFALCWLPVHT- 251
Cdd:cd15928  162 SGLLSVMLWVSTSFF---FVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHR-QTVRMLAVIVLAFVLCWLPFHVg 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 121957962 252 -INCASLFQPTWAKVKPKWAIN-TAILLSHANSAVNPIVYAYRNRDFRY 298
Cdd:cd15928  238 rVIFNHSRASTKHLHYVSQYFNlVSFVLFYLSAAINPILYNLMSKRYRY 286
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
22-297 5.18e-13

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 68.24  E-value: 5.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVtiSLGFCTDFH----SCLFLACFVLVLTQSSIFSLL 97
Cdd:cd14999   14 VAGNVYTLVVMCLSMRPRASMYVYILNLALADLLY-LLTIPFYV--STYFLKKWYfgdvGCRLLFSLDFLTMHASIFTLT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARaRGVIAALWVLAFGIGLtPFLgwndrkIATNCTEPGDaatnVSCCLIRCLFENVVP 177
Cdd:cd14999   91 VMSTERYLAVVKPLDTVKRSKSYR-KLLAGVIWLLSLLLTL-PMA------IMIRLVTVED----KSGGSKRICLPTWSE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFN--FFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQReihAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd14999  159 ESYKVYLTllFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPKQK---VLKMIFTIVLVFWACFLPFWIWQLL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 256 SLFQPTwAKVKPKWAINTAIL---LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd14999  236 YLYSPS-LSLSPRTTTYVNYLltcLTYSNSCINPFLYTLLTKNYK 279
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
22-297 7.67e-13

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 67.90  E-value: 7.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVT--------ISLGFCTDFHSCLFLACfvlvlTQSSI 93
Cdd:cd15132   15 VTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLI-LLCLPFDLYrlwksrpwIFGEFLCRLYHYISEGC-----TYATI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFL---------GWNDRKIATNCTEPGDAatnVS 164
Cdd:cd15132   89 LHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFAL-LSAGPFLflvgveqdnNIHPDDFSRECKHTPYA---VS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 165 CCLIRCLFenVVPMSYMVYfnffgcvlpPLLIMLVIYVKIflvaCRQLQRTELMDHSRTVLQRE---IHAAKSLALIVGI 241
Cdd:cd15132  165 SGLLGIMI--WVTTTYFFL---------PMLCLSFLYGFI----GRKLWKSKNDLRGPNAAARErshRQTVRILAVVVLA 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 242 FALCWLPVHT--INCASLFQPTWAKVKPKWAInTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15132  230 FIICWLPFHIgrILFANTEDYRTMMFSQYFNI-VAMQLFYLSASINPILYNLISRKYR 286
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-300 7.89e-13

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 67.49  E-value: 7.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLfAIPFAVTISLGFCTDFHSclFLACFVLVLTQ----SSIFSLLAV 99
Cdd:cd15093   17 GNSLVIYVVLRYAKMKTVTNIYILNLAIADELFML-GLPFLAASNALRHWPFGS--VLCRLVLSVDGinmfTSIFCLTVM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFlgwndrkIATNCTEPGDAAtnVSCCLIRCLFENVVPMS 179
Cdd:cd15093   94 SVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVV-------VFAGTRENQDGS--SACNMQWPEPAAAWSAG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLPPLLIMLViyvkiFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQ 259
Cdd:cd15093  165 FIIYTFVLGFLLPLLIICLC-----YLLIVIKVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121957962 260 PTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15093  240 QLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
22-300 7.96e-13

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 67.83  E-value: 7.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPfaVTISLGFCTDFHSCLFLACFVLVLTQSSI----FSLL 97
Cdd:cd14977   15 IIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVP--LNAYNLLTKDWLFGDVMCKLVPFIQVTSLgvtvFSLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIatnctEPGDAATNVSCCL-IRCLFENVV 176
Cdd:cd14977   93 ALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARE-----SSLDNSSLTVCIMkPSTPFAETY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMV-YFNFFGCVlpPLLIMLVIYvkiFLVACRQLQ-RTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINC 254
Cdd:cd14977  168 PKARSWwLFGCYFCL--PLAFTAVCY---LLMARTLIRaAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEHISNI 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 255 ASLFQPTWAKVKPKWAIN----TAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14977  243 LRATLYNEVLIDTRSTLDildlIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
22-297 8.80e-13

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 67.48  E-value: 8.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQ--SSIFSLLA 98
Cdd:cd15088   15 LVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPFlIHQFAIDGQWYFGEVMCKIITALDANNqfTSTYILTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFlgWNDRKIatnctEPGDAATNVscCLIRcLFENVVPM 178
Cdd:cd15088   94 MSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASF-LSILPV--WVYSSL-----IYFPDGTTF--CYVS-LPSPDDLY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLpPLLIMLVIYVKIFlvacRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15088  163 WFTIYHFILGFAV-PLVVITVCYILIL----HRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLA 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121957962 259 --QPTWAKVkpkWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15088  238 mnRPTLAFE---VAYFLSICLGYANSCLNPFVYILVSENFR 275
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
22-297 1.29e-12

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 67.07  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCL-----FLACFVLVLtqsSIFSL 96
Cdd:cd15397   15 LLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLckmtpFIQCMSVTV---SILSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSLVTgaRARGVIAALWVLAFGIGLtPFLGWN--DRKIATNCTEPGDAATNVSCCLIRCLFEN 174
Cdd:cd15397   92 VLIALERHQLIINPTGWKPSVS--QAYLAVVVIWMLACFISL-PFLAFHilTDEPYKNLSHFFAPLADKAVCTESWPSEH 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 175 --VVPMSYMVYFNFfgCVlpPLLIMLVIYVKIFLvacRQLQRTELMDHSRTVLQREIHAAK---SLALIVGIFALCWLPV 249
Cdd:cd15397  169 hkLAYTTWLLLFQY--CL--PLLFILVCYLRIYL---RLRRRKDMLERRGEYNRRAGHSKRinvMLVSLVAAFALCWLPL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 121957962 250 HTINCASLFQPTWAKVKPKWAINTAI-LLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15397  242 NVFNAIADWNHEAIPHCQHNLIFSLChLAAMASTCVNPIIYGFLNSNFK 290
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
22-287 1.40e-12

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 66.91  E-value: 1.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15927   15 VLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEflCKLSEFLKDTSIGVSVFTLTAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATnctepGDAATNVSCCLIRCLFENVVPMS 179
Cdd:cd15927   95 SADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAI-PEAIFSHVVTFT-----LTDNQTIQICYPYPQELGPNYPK 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLPPLLIMLVIYV---KIFLVACRQLQrTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15927  169 IMVLLRFLVYYLIPLLIIGVFYVlmaRHLIRSTRNIG-SGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHVFMLWF 247
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121957962 257 LFQPTwAKVKPK--WAINTAI--LLSHANSAVNPI 287
Cdd:cd15927  248 HFAPN-GLVDYNafWHVLKIVgfCLSFINSCVNPV 281
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
22-289 1.42e-12

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 67.06  E-value: 1.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIpfAVTISLGFCTDFHSCLFlACFVL-----VLTQSSIFSL 96
Cdd:cd15197   15 VVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINV--LTDIIWRITVEWRAGDF-ACKVIrylqvVVTYASTYVL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSlvTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNctepgdaatNVSCCLIrcLFENVV 176
Cdd:cd15197   92 VALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSIPMLIIFEKTGLSNG---------EVQCWIL--WPEPWY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGCVLPPLLI---MLVIYVKIFLVACRQLQRTELMDH--------SRTVLQR-EIHAAKSLALIVGIFAL 244
Cdd:cd15197  159 WKVYMTIVAFLVFFIPATIIsicYIIIVRTIWKKSKIQVTINKAGLHdgssrrssSRGIIPRaKIKTIKMTFVIVTVFII 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 245 CWLPVHTINCASLFQpTWAKVKPKWAINTAIL-LSHANSAVNPIVY 289
Cdd:cd15197  239 CWSPYFVFDLLDVFG-LLPRSKTKIAAATFIQsLAPLNSAINPLIY 283
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
42-297 1.51e-12

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 66.66  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  42 TNYFLVSLAAADVAVGLFAIPF-AVTISLGFCtDFHS--CLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVT 118
Cdd:cd15002   36 IDSLILNLSAADLLLLLFSVPFrAAAYSKGSW-PLGWfvCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQ 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 119 GaRARGVIAALWVLAFGIGLTPFLGwndRKIATnctepgDAATNVSCCLIRCLFENVvpMSYMVYFNFFGCVLPPLLIML 198
Cdd:cd15002  115 R-RITAVVASIWVPACLLPLPQWLF---RTVKQ------SEGVYLCILCIPPLAHEF--MSAFVKLYPLFVFCLPLTFAL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 199 VIYVKIFlvacRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLS 278
Cdd:cd15002  183 FYFWRAY----GQCQRRGTKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVAWLWLIHIKSSGSSPPQLFNVLAQLLA 258
                        250
                 ....*....|....*....
gi 121957962 279 HANSAVNPIVYAYRNRDFR 297
Cdd:cd15002  259 FSISSVNPIIFLLMSEEFR 277
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
24-300 1.55e-12

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 66.75  E-value: 1.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADvAVGLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQ-SSIFSLLAVAV 101
Cdd:cd15972   17 GNTLVIYVVLRYSASESVTNIYILNLALAD-ELFMLGLPFlAAQNALSYWPFGSFMCRLVMTVDAINQfTSIFCLTVMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDrkiatnctEPGDAATnvsCCLIRCLFENVVPMSYM 181
Cdd:cd15972   96 DRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVL-PVVIFSG--------VPGGMGT---CHIAWPEPAQVWRAGFI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VY---FNFFGcvlpPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIhaAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15972  164 IYtatLGFFC----PLLVICLCYLLIVVKVRSSGRRVRATSTKRRGSERKV--TRMVVIVVAAFVLCWLPFYALNIVNLV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15972  238 CPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
25-300 2.25e-12

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 66.44  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAI-------PFAVTISLgfctdfHSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15343   18 NSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVflmfntgPVSKTLTV------NRWFLRQGLLDTSLSASLTNLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVrVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdrkiatnctepgdAATNVSCClirCLFENVVP 177
Cdd:cd15343   92 VIAVERHISI-MRMKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGWN-------------CICNISAC---SSLAPIYS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLppLLIMLVIYVKIFLVACRqlQRTELMDHSRTVLQRE---IHAAKSLALIVGIFALCWLP------ 248
Cdd:cd15343  155 RSYLVFWSVSNLVV--FLIMVVVYLRIYVYVQR--KTNVLSPHTSGSINRRrtpIKLMKTVMTVLGAFVICWTPglvvll 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 249 VHTINCAslfQPTWAKVKpKWAINTAILlshaNSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15343  231 LDGLNCT---RCGVQHVK-RWFLLLALL----NSVMNPIIYSYKDEEMWGTM 274
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
21-300 3.18e-12

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 65.97  E-value: 3.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFA--IPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15082   27 SLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGgtISFLTNARGYFFLGVWACVLEGFAVTFFGIVALWSLAV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGvIAALWVLAFGIGLTPFLGWND---RKIATNCtEPGDAATNVScclirclfenv 175
Cdd:cd15082  107 LAFERFFVICRPLGNIRLQGKHAALG-LLFVWTFSFIWTIPPVLGWSSytvSKIGTTC-EPNWYSGNMH----------- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 vPMSYMVYFnFFGCVLPPLLIMLVIYVKIFlvacRQLQR-TELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINC 254
Cdd:cd15082  174 -DHTYIITF-FTTCFILPLGVIFVSYGKLL----QKLRKvSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAAFSI 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 255 ASLFQPTwAKVKPKWAINTAiLLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15082  248 LVTAHPT-IHLDPRLAAIPA-FFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
21-300 3.36e-12

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 65.58  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--------GFCTdfhscLFLACFVLVLTqSS 92
Cdd:cd15296   14 TVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLtgrwkfgrGLCK-----LWLVVDYLLCT-AS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGAR-ARGVIAALWVLAFGIGLTPFLGWnDRKIATNCTEPGDAAT----NVSCCL 167
Cdd:cd15296   88 VFNIVLISYDRFLSVTRAVSYRAQKGMTRqAVLKMVLVWVLAFLLYGPAIISW-EYIAGGSIIPEGECYAeffyNWYFLM 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 IRCLFENVVPMSYMVYFNffgcvlppllimLVIYVKIflvacrqlqrtelmDHSRTVLQREIHAAKSLALIVGIFALCWL 247
Cdd:cd15296  167 TASTLEFFTPFISVTYFN------------LSIYLNI--------------QKRRFRLSRDKKVAKSLAIIVCVFGLCWA 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 248 P---VHTINCAslfqpTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15296  221 PytlLMIIRAA-----CHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
21-297 3.52e-12

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 65.63  E-value: 3.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVtisLGFCTDFHSCLFLACFVLVLTQS-----SIFS 95
Cdd:cd15008   13 SVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVL---LQFTSGRWTLGSAMCKLVRYFQYltpgvQIYV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  96 LLAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIgLTPFLGWNDRKIATNCTE-PGDAATNVSCCLIRCLFEN 174
Cdd:cd15008   90 LLSICVDRFYTIVYPLSFK--VSREKAKKMIAASWLFDAAF-VSPALFFYGSNWGPHCNFfLPDSWDGAAYAIIHLLVGF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 175 VVPMSYMVYFnffgcvlpplLIMLVIYVKIFLVACRQLQRTelmdhSRTVLQREIHAAKSLALIVGIFALCWLPVHTinc 254
Cdd:cd15008  167 LVPSILIILF----------YQKVIKYIWRIGTDGRTVRRT-----MNIVPRTKVKTIKMFLMLNSMFLLSWLPFYV--- 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 121957962 255 ASLFQPTWAKVKPKWAINTAI-LLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15008  229 VQLWHPRESDYRQSSLVFLAVtWISFSSSASKPTLYSVYNANFR 272
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
21-297 5.95e-12

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 65.11  E-value: 5.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIS-----LGFCTDFHSCLFLACFVLVLtqsSIFS 95
Cdd:cd15195   14 SAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNytvewLAGDLMCRVMMFLKQFGMYL---SSFM 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  96 LLAVAVDRYLAVRVPLRykslVTGARARGVIA--ALWVLAFGIGLTPFL------GWNDRKIATNCTEPGDAATnvsccl 167
Cdd:cd15195   91 LVVIALDRVFAILSPLS----ANQARKRVKIMltVAWVLSALCSIPQSFifsvlrKMPEQPGFHQCVDFGSAPT------ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 irclfENVVPMSYMvyFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTvLQREIHA-----AKSL---ALIV 239
Cdd:cd15195  161 -----KKQERLYYF--FTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPISNR-RRSRTNSlerarMRTLrmtALIV 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 240 GIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15195  233 LTFIVCWGPYYVLGLWYWFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIR 290
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
24-300 6.05e-12

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 64.97  E-value: 6.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADvAVGLFAIPFAVTISLGFCTDFHSCLflaCFVLVLTQ-----SSIFSLLA 98
Cdd:cd15089   17 GNVLVMYGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELL---CKAVLSIDyynmfTSIFTLTM 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLgwndrkiATNCTEPGDAATnvscclIRCLFENVVPM 178
Cdd:cd15089   93 MSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGV-PIM-------VMAVTKTPRDGA------VVCMLQFPSPS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFN----FFGCVLPPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHtinc 254
Cdd:cd15089  159 WYWDTVTkicvFIFAFVVPILVITVCYGLMIL----RLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIH---- 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 121957962 255 asLFQPTWAKVKPK-------WAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15089  231 --IFVIVWTLVDIDrrnplvvAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
24-297 7.59e-12

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 64.58  E-value: 7.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15214   16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVvwCNFSALLYLLISSASMLTLGAIAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRK--------IATNCTEPGDAAtnvscclirclfe 173
Cdd:cd15214   96 DRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEfdrfkwmcVAAWHKEAGYTA------------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 nvvpmsymvyFNFFGCVLPPLLIMLVIYVKIFLVAcrqlqrtelmdhsrtvLQREIHAAKSLALIVGIFALCWLPVHTIN 253
Cdd:cd15214  163 ----------FWQVWCALLPFVVMLVCYGFIFRVA----------------RANQCKAFITILVVLGAFVTTWGPYMVVI 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 254 CAslfQPTWAKVKPKWAINT-AILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15214  217 ST---EALWGKNSVSPQLETlATWLSFTSAVCHPLIYGLWNKTVR 258
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
21-296 7.89e-12

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 65.18  E-value: 7.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAaVGTSSALQTPTNYFLVSLAAADVavgLFAIPFAVTI--------SLGFCTdfhsCLFLACFVLVLTQSS 92
Cdd:PHA03087  54 GLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDL---LFVMTLPFQIyyyilfqwSFGEFA----CKIVSGLYYIGFYNS 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWNDRKiatnctepgdaatNVSCCLIRCLF 172
Cdd:PHA03087 126 MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISI-IETTPILFVYTTK-------------KDHETLICCMF 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYFNFFGCV---LPPLLIMLVIYVKIFLVACRQLQRTelmdhsrtvlqREIHAAKSLALIVGIFALCWLPV 249
Cdd:PHA03087 192 YNNKTMNWKLFINFEINIigmLIPLTILLYCYSKILITLKGINKSK-----------KNKKAIKLVLIIVILFVIFWLPF 260
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 121957962 250 H------TINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDF 296
Cdd:PHA03087 261 NvsvfvySLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFF 313
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
24-300 1.10e-11

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 64.50  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVT-ISLGFCTdFHSCLflaCFVLVLTQ-----SSIFSLL 97
Cdd:cd15092   17 GNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTdIFLGFWP-FGNAL---CKTVIAIDyynmfTSTFTLT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkiatnctePGDAATNVSCclIRCLFENVVP 177
Cdd:cd15092   92 AMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMV-------------MGSAQVEDEE--IECLVEIPTP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYmvYFNFFG-CV-LPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd15092  157 QDY--WDPVFGiCVfLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLA 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 256 SLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15092  235 QGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
22-297 1.13e-11

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 64.46  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15078   15 VCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVrgRWVFDVAGCVWDGFSNSLFGIVSIMTLTVL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVrvplRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATN---------CTEPGDAAtnvscclirc 170
Cdd:cd15078   95 AYERYIRV----VHAKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEVHglgcsfdwkSKDPNDTS---------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 lfenvvpmsyMVYFNFFGCVLPPLLIMLVIYVKIfLVACRQLQRTELMDHSRTV--LQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd15078  161 ----------FVLLFFLGCLVVPLGIMAYCYGHI-LYEIRMLRSVEDLQTFQVIkiLKYEKKVAKMCLLMISTFLICWMP 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 121957962 249 vHTINCASLFQPTWAKVKPKWAINTAiLLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15078  230 -YAVVSLLVTSGYSKLVTPTIAIIPS-LFAKSSTAYNPVIYIFMIRKFR 276
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
24-300 1.13e-11

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 64.28  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGL--FAIPFAVTISLGFCTdFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15344   17 ANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLayFYLMFNTGPNTRRLT-VSTWLLRQGLIDTSLTASVANLLAIAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVrVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNvscclirclfenvvpmSYM 181
Cdd:cd15344   96 ERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSD----------------SYL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFFGCVlpPLLIMLVIYVKIFL-VACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLP-----VHTINCA 255
Cdd:cd15344  159 VFWAIFNLV--TFVVMVVLYAHIFGyVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPglvllLLDVCCP 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 256 SLFQPTWAKVkpkwaintAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15344  237 QCDVLAYEKF--------FLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
25-300 1.15e-11

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 64.13  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGlfaIPFAVTISLGFCTDFH----SCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd15346   18 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG---VAYTANLLLSGATTYKltptQWFLREGSMFVALSASVFSLLAIA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 101 VDRYLAVrVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTepgdaatnvscclirclfeNVVPMSY 180
Cdd:cd15346   95 IERYITM-LKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSCS-------------------TVLPLYH 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 181 MVYFNFFGCVLPPLLIMLVI-YVKIF-LVACRQLQRTELMDHSRTVLQREIHAA--KSLALIVGIFALCWLPV------- 249
Cdd:cd15346  155 KHYILFCTTVFTLLLLSIVIlYCRIYsLVRTRSRRLTFRKNIRKASRSSEKSMAllKTVIIVLSVFIACWAPLfilllld 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 250 ---HTINCASLFqptwakvKPKWAINTAILlshaNSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15346  235 vgcKVKTCSILF-------KAEYFLVLAVL----NSATNPIIYTLTNKEMRRAF 277
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
24-300 1.20e-11

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 64.16  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15970   17 GNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFLVTSTLLRHWPFGSllCRLVLSVDAINMFTSIYCLTVLSI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNCTepgdaatnVSCCLIRCLFENVVPMSYM 181
Cdd:cd15970   96 DRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVIL-PIIIFSNTAPNSDGS--------VACNMQMPEPSQRWLAVFV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFFGCVLPPLLIML---VIYVKIFLVACR----QLQRTElmdhsrtvlqREIhaAKSLALIVGIFALCWLPVHTINC 254
Cdd:cd15970  167 VYTFLMGFLLPVIAICLcyiLIIVKMRVVALKagwqQRKRSE----------RKI--TLMVMMVVTVFVICWMPFYVVQL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 255 ASLFqptwAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15970  235 VSVF----VGQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
22-297 1.34e-11

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 63.82  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLgFCTDFHS---CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15210   15 VPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFL-HQAWIHGetlCRVFPLLRYGLVAVSLLTLVL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLG-WNDRKIatnctepgdaATNVSCCLIrclFENVVP 177
Cdd:cd15210   94 ITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGiWGRFGL----------DPKVCSCSI---LRDKKG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLPPLLImlviyvkIFLVACRQLQRTELMdhsrtvlqreihaaksLALIVGIFALCWLPVHTINCASl 257
Cdd:cd15210  161 RSPKTFLFVFGFVLPCLVI-------IICYARREDRRLTRM----------------MLVIFLCFLVCYLPITLVNVFD- 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 121957962 258 fqptwAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15210  217 -----DEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYR 251
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
24-300 1.41e-11

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 64.08  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15981   17 GNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLitGWPFDNAMCKMSGLVQGMSVSASVFTLVAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKslVTGARARGVIAALWVLAFGI----GLTPFLGWNDRKIATNctepgdaATNVSCCLIRCLFENVVP 177
Cdd:cd15981   97 ERFRCIVHPFRQK--LTLRKAIVTIVIIWVLALIImcpsAVTLTVTREEHHFMVD-------DYNNSYPLYSCWEAWPDT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFN--FFGCVLPPLLIMLVIYVKIFLVACR--------QLQRTElmdhSRTVLQREIHAAKSLALIVGIFALCWL 247
Cdd:cd15981  168 EMRKIYTTvlFSHIYLAPLTLIVIMYARIAFKLFKssapirgsQGEEEE----GRRVSKRKIKVINMLIIVALFFTLSWL 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 248 PVHT----INCASLFQPTWAKVKpKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15981  244 PLWTlmllTDYGHLSEDQLNLVT-VYVFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
21-300 1.60e-11

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 63.80  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVS-LAAADVAVG--LFAIPFAVTISLGFCTDFHS-------CLfLACFVLVL-T 89
Cdd:cd14980   14 ALIGNILVIIWHISSKKKKKKVPKLLIInLAIADFLMGiyLLIIAIADQYYRGRYAQYSEewlrsppCL-LACFLVSLsS 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  90 QSSIFSLLAVAVDRYLAVRVPLRYKSLvTGARARGVIAALWVLAFGIGLTPFLG-----WNDRKIATN--CTePGDaatn 162
Cdd:cd14980   93 LMSVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIFAAIPILYsinqpGDNRLYGYSsiCM-PSN---- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 163 vscclirclFENVVPMSYMVYFNFFGCVLppLLIMLVIYVKIFlVACRQLQRTElmdhSRTVLQREIHAAKSLALIVGIF 242
Cdd:cd14980  167 ---------VSNPYYRGWLIAYLLLTFIA--WIIICILYILIF-ISVRKSRKSA----RRSSSKRDKRIAIRLALILITD 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 243 ALCWLPVHTINCASLFQPTWAKV-KPKWAintAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14980  231 LICWLPYYIVIFSGLLTSTEIDIhVLQFI---AILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
21-297 2.20e-11

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 63.51  E-value: 2.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV------TISLGFCTDFHSCLFLACFVLVltqsSIF 94
Cdd:cd15389   14 SLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLvrfvnsTWVFGKIMCHLSRFAQYCSVYV----STL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  95 SLLAVAVDRYLAVRVPLRYK-SLVTGARargVIAALWVLAFGIGLtPFLGWNDRKIATNCTEpgdaaTNVSCCLIRCLFE 173
Cdd:cd15389   90 TLTAIALDRHRVILHPLKPRiTPCQGVV---VIAIIWIMASCLSL-PHAIYQKLVEFEYSNE-----RTRSRCLPSFPEP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVVPMSYMVYFNFFGCVLPPLLIMLVIYVKiflVACRQLQRTELMDHSRTVLQREIHAAKS----LALIVGIFALCWLPV 249
Cdd:cd15389  161 SDLFWKYLDLATFILQYVLPLLIIGVAYTR---VAKKLWLRNAIGDVTTEQYVAQRRKKKKtikmLMLVVLLFAICWLPL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 250 HTINCASLFQPTWAKvkpkwaiNTAILLSH--ANSAV--NPIVYAYRNRDFR 297
Cdd:cd15389  238 NCYHVLLSSHPIRSN-------SALFFAFHwlAMSSTcyNPFIYCWLNDSFR 282
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
26-297 2.55e-11

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 63.48  E-value: 2.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  26 VLVCAAVGTSSALQT----------PTNYFLVSLAAADVAVGLFAIP----FAVTISLgFCTDF--HSCLFLACFVLVLt 89
Cdd:cd15382   10 LFLIAAVGNLTVLLIllrnrrrkrsRVNILLMHLAIADLLVTFIMMPleigWAATVAW-LAGDFlcRLMLFFRAFGLYL- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  90 qsSIFSLLAVAVDRYLAVRVPLRykSLVTGARARGVIAALWVLAFGIGLTpflgwndrKIATNCTEPGDAATNVSCCLIR 169
Cdd:cd15382   88 --SSFVLVCISLDRYFAILKPLR--LSDARRRGRIMLAVAWVISFLCSIP--------QSFIFHVESHPCVTWFSQCVTF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 clfeNVVPMSYMVYFNFFGCVLP----PLLIMLVIYVKIFLVACRQLQRTELMDH---SRTVLQRE----IHAAKSLAL- 237
Cdd:cd15382  156 ----NFFPSHDHELAYNIFNMITmyalPLIIIVFCYSLILCEISRKSKEKKEDVSeksSSVRLRRSsvglLERARSRTLk 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121957962 238 ----IVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15382  232 mtivIVLVFIICWTPYFIMSLWYWFDRESASKVDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLR 295
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
89-297 2.73e-11

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 62.99  E-value: 2.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  89 TQSSIFSLLAVAVDRYLAVRVPLRYKSLvTGARARGVIAALWVLAFGIGLTPFLGWNdrkiatncTEPGDAATNvSCCLI 168
Cdd:cd15137   91 SEVSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLAVLPLLPWD--------YFGNFYGRS-GVCLP 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 169 RCLfENVVPMS--YMVyFNFFGCVLPPLLIMLVIYVKIFlvacRQLQRTELMDHSRTVlQREIHAAKSLALIVGIFALCW 246
Cdd:cd15137  161 LHI-TDERPAGweYSV-FVFLGLNFLAFVFILLSYIAMF----ISIRRTRKAAASRKS-KRDMAVAKRFFLIVLTDFLCW 233
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 247 LPVHTINCASLFQPTWAKVKPKWainTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15137  234 IPIIVIGILALSGVPIPGEVYAW---VAVFVLPINSALNPILYTLSTPKFR 281
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
8-143 3.61e-11

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 63.25  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPF---AVTISLGFCTDFHSCLFLACF 84
Cdd:cd15005    1 ALKLTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFvmaSVRHGSGWIYGALSCKVIAFL 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962  85 VLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLG 143
Cdd:cd15005   81 AVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFD 139
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
22-297 3.75e-11

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 62.98  E-value: 3.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLfAIPFAVTISLGFCTDFHSCLFLACFVLV---LTQSSIFSLLA 98
Cdd:cd15131   15 VTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFL-CMPLDLYRLWQYRPWNFGDLLCKLFQFVsesCTYSTILNITA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFG--------IGLTPFLGWNDRKiaTNCTEPGDAATNVSCCLIRC 170
Cdd:cd15131   94 LSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLsagpifvlVGVEHENGTNPID--TNECKATEYAVRSGLLTIMV 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 LFENVvpmsymvyfnFFgcvLPPLLIMLVIYVKIflvaCRQLQRTELMDHSRTVLQREI---HAAKSLALIVGIFALCWL 247
Cdd:cd15131  172 WVSSV----------FF---FLPVFCLTVLYSLI----GRKLWRRRRENIGPNASHRDKnnrQTVKMLAVVVFAFVLCWL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 248 PVHTINcaSLFQPTWAKVKPKWAINT------AILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15131  235 PFHVGR--YLFSKSFEAGSLEIALISqycnlvSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
39-300 4.19e-11

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 62.52  E-value: 4.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  39 QTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLF-LACFVLVLTQ-SSIFSLLAVAVDRYLAVRVPLRYKSL 116
Cdd:cd14976   34 QSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCkVVRYVTKLNMySSIFFLTALSVTRYIAVARALKHGWI 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 117 VTGARARGVIAALWVLAFGIGLTPflgwndrkiATNCTEPGDAAtNVSCCLIRCLFENVVPMSYM---------VYFNFF 187
Cdd:cd14976  114 RKAFGAFATTIAIWAAAALAAIPE---------AIFSTDTWSSV-NHTLCLLRFPKNSSVTRWYNwlgmyqlqkVVLGFF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 188 GcvlpPLLIMLVIYVKIFLVACRQLQRTElmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTINCASL--------FQ 259
Cdd:cd14976  184 L----PLGIITLSYLLLLRFLQRKRGGSK---------RRKSRVTKSVFIVVLSFFICWLPNQALSLWSAlikfddvpFS 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121957962 260 PTWAKVKPKwAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14976  251 DAFFAFQTY-AFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
22-297 4.23e-11

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 62.78  E-value: 4.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPF-AVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLA 98
Cdd:cd14985   15 LLGNLFVVWVFLFPRGPKRVADIFIANLAAADL-VFVLTLPLwATYTANQYDWPFGAflCKVSSYVISVNMFASIFLLTC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATnctepgdaaTNVSCClIRCLFENVVPM 178
Cdd:cd14985   94 MSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIEN---------LNKTAC-IMLYPHEAWHF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLpPLLIMLVIYvkiFLVACRQLQRTELMDHSRTVLQREIhaaKSLALIVGIFALCWLPVHTIncASLF 258
Cdd:cd14985  164 GLSLELNILGFVL-PLLIILTCY---FHIARSLRKRYERTGKNGRKRRKSL---KIIFALVVAFLVCWLPFHFF--KFLD 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 259 QPTWAKVKP--------KWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd14985  235 FLAQLGAIRpcfwelflDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
22-297 5.33e-11

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 62.45  E-value: 5.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFavtiSLGFCTDFHSCLF--LACFVLVLTQS-----SIF 94
Cdd:cd15394   15 VVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPL----TLAYAFEPRGWVFgrFMCYFVFLMQPvtvyvSVF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  95 SLLAVAVDRYLAVRVPLRYK-SLVTGARargVIAALWVLAFGIGL-----TPFLGWNDRKIATnCTEpgdaatnvsccli 168
Cdd:cd15394   91 TLTAIAVDRYYVTVYPLRRRiSRRTCAY---IVAAIWLLSCGLALpaaahTYYVEFKGLDFSI-CEE------------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 169 rclFENVVPMSYMVYFNFFGCV--LPPLLIMLVIYVKIFLvacrQLQRtELMDHSRTVLQREIHAAKS------LALIVG 240
Cdd:cd15394  154 ---FWFGQEKQRLAYACSTLLItyVLPLLAISLSYLRISV----KLRN-RVVPGSMTQSQAEWDRARRrktfrlLVVVVV 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121957962 241 IFALCWLPVHTINCASLFQPTWAKvkpKWAINTAILLSH----ANSAVNPIVYAYRNRDFR 297
Cdd:cd15394  226 AFAICWLPLHIFNVIRDIDIDLID---KQYFNLIQLLCHwlamSSACYNPFLYAWLHDSFR 283
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
21-297 7.91e-11

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 61.48  E-value: 7.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAI--PFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15196   14 ALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVlpQLIWDITYRFYGGDLLCRLVKYLQVVGMYASSYVLVA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLvTGARARGVIAALWVLAFGIGLTPFLGWNDRkiatnctEPGDAATNVSCclirCLFENVVPM 178
Cdd:cd15196   94 TAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLFIFSYQ-------EVGSGVYDCWA----TFEPPWGLR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFGCVLpPLLIMLVIYVKIflvaCRQLQRTELmdhsRTVlqreihaaKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15196  162 AYITWFTVAVFVV-PLIILAFCYGRI----CYVVWRAKI----KTV--------KLTLVVVACYIVCWTPFFVVQMWAAW 224
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 121957962 259 QPTWAKVKPkwAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15196  225 DPTAPIEGP--AFVIIMLLASLNSCTNPWIYLAFSGNLR 261
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
25-300 8.45e-11

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 61.37  E-value: 8.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLfaiPFAVTISLGFCTDFH----SCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd15347   18 NLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGV---AFIANILLSGSVTFRltpvQWFIREGTAFITLSASVFSLLAIA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 101 VDRYLAVRVPLRYKSLVTgARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTepgdaatnvscclirclfeNVVPMSY 180
Cdd:cd15347   95 IERHVAITKVKLYGSDKN-CRMVLLIGACWVISIVLGGLPILGWNCIGNLEDCS-------------------TVLPLYS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 181 MVYFNFFGCVLPPLLIMLVI-YVKIFLVAcrqlqRTElmdHSRTVLQREIHAAKSLALIVGIFALCWLPVHTIncasLFQ 259
Cdd:cd15347  155 KHYILFVVTIFSIILLSIVIlYVRIYCIV-----RSS---HAEMAAPQTLALLKTVTIVLGVFIVCWLPAFII----LLL 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 121957962 260 PTWAKVKPKWAINTA---ILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15347  223 DTSCKVKSCPILYKAdyfFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
91-300 8.64e-11

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 61.37  E-value: 8.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVrVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTepgdaatnvscclirc 170
Cdd:cd15345   85 ASTFSLLAIAIERHLTM-IKMRPYDANKRYRVFLLIGTCWLISVLLGALPILGWNCLDNLPDCS---------------- 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 lfeNVVPMSYMVYFNFFGCVLPPLLIMLVI-YVKIFLVACRQLQRteLMDHSRTvlQREIHAAKSLALIVGIFALCWLPV 249
Cdd:cd15345  148 ---TILPLYSKKYVAFCISIFIAILVAIVIlYARIYILVKSSSRR--VTNHRNS--ERSMALLRTVVIVVGVFIACWSPL 220
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 250 HT---INCASLFQPTWAKVKPKWAINTAILlshaNSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15345  221 FIlllIDVACEVKQCPILYKADWFIALAVL----NSAMNPIIYTLASKEMRRAF 270
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
21-297 8.85e-11

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 61.85  E-value: 8.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15081   26 SVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVnqIFGYFILGHPMCVLEGFTVSVCGITGLWSLTI 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLvTGARARGVIAALWVLAFGIGLTPFLGWN---DRKIATNC--------TEPGdaatnvsccl 167
Cdd:cd15081  106 ISWERWVVVCKPFGNIKF-DGKLAIVGIIFSWVWSAVWCAPPIFGWSrywPHGLKTSCgpdvfsgsSDPG---------- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 168 irclfenvvPMSYMVYFNFFGCVLpPLLIMLVIYVKIFLvACRQLQRTELMDHSRTVLQREIhaakSLALIVGIFA--LC 245
Cdd:cd15081  175 ---------VQSYMIVLMITCCII-PLAIIILCYLQVWL-AIRAVAQQQKESESTQKAEKEV----SRMVVVMIFAycFC 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 246 WLPVHTINCASLFQPTWAkVKPKWAINTAILLSHAnSAVNPIVYAYRNRDFR 297
Cdd:cd15081  240 WGPYTFFACFAAANPGYA-FHPLAAALPAYFAKSA-TIYNPIIYVFMNRQFR 289
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
24-291 1.13e-10

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 61.37  E-value: 1.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAiPFAVTISLGFCTDFHSCLFLACFVL--VLTQSSIFSLLAVAV 101
Cdd:cd15121   17 GNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTA-PFFLHFLSGGGWEFGSVVCKLCHYVcgVSMYASIFLITLMSM 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWndRKIATNctepgdaATNVSCCLIRCLFEnvvpmSYM 181
Cdd:cd15121   96 DRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSL-PMPFY--RTVLKK-------NINMKLCIPYHPSV-----GHE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFFGCVLPPLLIMLVIyVKIFLVACRQLQRTELMDHSRTvlqreihaAKSLALIVGIFALCWLPVHTINCASL---- 257
Cdd:cd15121  161 AFQYLFETITGFLLPFTAI-VTCYSTIGRRLRSARFRRKRRT--------NRLVVLIIATFALFWLPYHVVNLIQVagal 231
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121957962 258 -FQPTWAKV--KPKWAINTAILLSHANSAVNPIVYAY 291
Cdd:cd15121  232 qNQAGNASVlkAAKLARPNVTALAFLSSSVNPVLYAF 268
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
23-297 1.29e-10

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 61.32  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  23 TGNVLVCAAVGTSSA-LQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15190   26 SGNGLVLWTVFRSKRkRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSflCKLSSYLVFVNMYASVFCLTGL 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAfGIGLTPFLGWNdrkiatncTEPGDAATNVSCC------LIRCLFE 173
Cdd:cd15190  106 SFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLA-ALLALPALILR--------TTSDLEGTNKVICdmdysgVVSNESE 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVVPMSYMVYFNFFGCVLPpLLIMLVIYVKIFLVACRQLQRtelmdHSRTVLQREIHAAKSLALIVGIFALCWLPVHTIN 253
Cdd:cd15190  177 WAWIAGLGLSSTVLGFLLP-FLIMLTCYFFIGRTVARHFSK-----LRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVK 250
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 121957962 254 caSLFQPTWAKVKP------KWAINT---AILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15190  251 --TLYALMYLGILPfscgfdLFLMNAhpyATCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
22-300 1.38e-10

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 60.97  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPFAVTISLGFCTDFHSclFLACFVLVLTQ----SSIFSLL 97
Cdd:cd15974   15 LSGNTLVIYVVLRYAKMKTVTNIYILNLAVADE-LFMLGLPFLATQNAISYWPFGS--FLCRLVMTVDGvnqfTSIFCLT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDrkiatncTEPGDAATNVSCCLIRCLFENVVp 177
Cdd:cd15974   92 VMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVL-PVIIFSD-------VQPDLNTCNISWPEPVSVWSTAF- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGcvlpPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15974  163 IIYTAVLGFFG----PLLVICLCYLLIVI----KVKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 258 FQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15974  235 IVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
24-300 1.42e-10

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 61.16  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADvAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15090   17 GNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGNilCKIVISIDYYNMFTSIFTLCTMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkIATNCTEPGDAATNVSCCLIRCLFENVVPMSYM 181
Cdd:cd15090   96 DRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF------MATTKYRQGSIDCTLTFSHPSWYWENLLKICVF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYfnffgCVLPPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVH--TINCASLFQ 259
Cdd:cd15090  170 IF-----AFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHiyVIIKALVTI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121957962 260 PTWAKVKPKWAIntAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15090  241 PETTFQTVSWHF--CIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
22-300 1.51e-10

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 61.01  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQ-SSIFSLLAV 99
Cdd:cd15971   15 LCGNTLVIYVILRYAKMKTVTNIYILNLAIADELF-MLGLPFlAIQVALVHWPFGKAICRVVMTVDGINQfTSIFCLTVM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCtepgdaatnvSCCLIRCLFENVVPMS 179
Cdd:cd15971   94 SIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRS----------SCTIIWPGESSAWYTG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLpPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQ 259
Cdd:cd15971  164 FIIYTFILGFFV-PLTIICLCYLFIII----KVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121957962 260 PTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15971  239 SISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
25-300 1.80e-10

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 60.52  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG--FCTDFHSCLFL----ACFVLVltqsSIFSLLA 98
Cdd:cd15086   18 NLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQgrWLIGEHGCRWYgfanSLFGIV----SLISLAV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRyKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKI---ATNCTEPGDAATNVSCCLIRCLfenv 175
Cdd:cd15086   94 LSYERYCTLLRPTE-ADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPegpGTTCSVQWTSRSANSISYIICL---- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 vpmsymvyfnFFGCVLPPLLIMLVIYVKIfLVACRQLQRTelmdHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd15086  169 ----------FIFCLLLPFLVMVYCYGRL-LYAIKQVGKI----NKSTARKREQHVLLMVVTMVICYLLCWLPYGVMALL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 256 SLFQPTwAKVKPKWAINTAIlLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15086  234 ATFGKP-GLVTPVASIVPSI-LAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
21-297 1.83e-10

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 60.56  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLF-AIPFAVTISLG-FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15075   14 SVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFgGLLSVVTNAVGyFNLGRVGCVLEGFAVAFFGIAALCTVAV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRyKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEpgdaatnvscCLIRCLFENVVPM 178
Cdd:cd15075   94 IAVDRLFVVCKPLG-TLTFQTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVMTS----------CAPDWYSRDPVNV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMV-YFNFfgCVLPPLLIMLVIYVKIfLVACRQLQRtELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15075  163 SYILcYFSF--CFAIPFAIILVSYGYL-LWTLRQVAK-LGVAEGGSTAKAEVQVARMVVVMVMAFLLCWLPYAAFALTVV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 121957962 258 FQPTwAKVKPKWAInTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15075  239 SKPD-VYINPLIAT-VPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
21-289 2.26e-10

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 60.44  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVavgLFAIPFAVTIS---LGFCTDFHS--CLFLACFVLVLTQSSIFS 95
Cdd:cd15159   14 GLLGNTLALHVICQKRKKINSTTLYLINLAVSDI---LFTLALPGRIAyyaLGFDWPFGDwlCRLTALLFYINTYAGVNF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  96 LLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLgwndrkIATNCTEPGDAATnvscCLIRCLFENV 175
Cdd:cd15159   91 MTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTL-PLL------FMPMTKEMGGRIT----CMEYPNFEKI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVyfnFFGCVLP---PLLIMLVIYVKIFLVACRQLQRTELMDHSrtvlQREIHAAKSLALIVGIFALCWLPVHtI 252
Cdd:cd15159  160 KRLPLIL---LGACVIGfgvPVGIILFCYSQITLKLCRTAKENPLTEKS----GHHKKACNVILLVLLVFVVCFSPYH-L 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 121957962 253 NCAS------LFQPTWA-KVKPKWAINTAILLSHANSAVNPIVY 289
Cdd:cd15159  232 NIIQfmirklLYQPSCSeLKAFKISLQITVCLMNLNCCLDPFIY 275
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
22-297 2.65e-10

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 60.18  E-value: 2.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15209   15 VLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFhnGWTLGQLHCQASGFIMGLSVIGSIFNITAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkIATNCTEPGdaatnvsccLIRCLFENVVPMS 179
Cdd:cd15209   95 AINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFF------IGSLQYDPR---------IYSCTFAQTVSTV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRTElMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQ 259
Cdd:cd15209  160 YTITVVVIHFLL-PLLIVSFCYLRIWVLVLQVRQRVK-PDQRPKLKPADVRNFLTMFVVFVLFAVCWAPLNFIGLAVAIN 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 121957962 260 PTWAKVK-PKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15209  238 PKEMAPKiPEWLFVASYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
21-121 5.00e-10

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 59.44  E-value: 5.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIslgFCTDFHSCLFLACFV-------LVLTQSSI 93
Cdd:cd15222   14 ALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGI---FWFNAREISFDACLAqmffihtFSFMESSV 90
                         90       100
                 ....*....|....*....|....*...
gi 121957962  94 fsLLAVAVDRYLAVRVPLRYKSLVTGAR 121
Cdd:cd15222   91 --LLAMAFDRFVAICNPLRYASILTNSR 116
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
24-300 6.98e-10

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 59.19  E-value: 6.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPfaVTISLGFCTDFH----SCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15125   17 GNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVP--VDASRYFYEEWMfgtvGCKLIPVIQLTSVGVSVFTLTAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgigltpFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVVP-- 177
Cdd:cd15125   95 SADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSV------LLAVPEAVFSEVAHIMPDDNTTFTACIPYPQTDEMHPki 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 ---MSYMVYFnffgcvLPPLLIMLVIYVKIFLVACRQLQRT--ELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTI 252
Cdd:cd15125  169 hsvLIFLVYF------LIPLAIISIYYYHIAKTLIKSAHNIpgEYSEHSKRQMETRKRLAKIVLVFVGLFAFCWFPNHVL 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 253 NCASLFQptWAKVKPKWA----INTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15125  243 YMYRSFN--YNEIDSSLGhmivTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
22-297 7.66e-10

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 58.68  E-value: 7.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGlFAIPFAVTISLGFCTDFHSCLFLA--CFVLVLTQSSIFSLLAV 99
Cdd:cd15348   15 VLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAG-AAYAANILMSGANTLKLTPALWFLreGGVFITLTASVFSLLAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVrVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndrkiatNCTEPGDAATnvscclirclfeNVVPMS 179
Cdd:cd15348   94 AIERHITM-VRMKPYPGDKRGRMFLLIGAAWLVSILLGVLPILGW-------NCLGNLDACS------------TVLPLY 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFfgCVLPPLLIML---VIYVKIFLVACRQLQRTELMDHSRTVL---QREIHAAKSLALIVGIFALCWLPVHT-- 251
Cdd:cd15348  154 AKSYILF--CITVFLAILAaivVLYARIYRIVKANSQRLGALPTRKGRArrsQKYLALLKTVTIVLGTFVACWLPLFLll 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 121957962 252 ---INCASLFQPTWAKVKPkwaintAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15348  232 lldVSCPAQACPVLLKADY------FLGLAMINSLLNPIIYTLTSRDMR 274
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
21-138 7.80e-10

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 58.58  E-value: 7.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIslgFCTDFHSCLFLACFV---LVLTQSSIFS-- 95
Cdd:cd15950   14 ALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSI---FWLGSAEISFEACFTqmfFVHSFTAVESgv 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 121957962  96 LLAVAVDRYLAVRVPLRYKSLVTGArargVIAALWVLAFGIGL 138
Cdd:cd15950   91 LLAMAFDRYVAICHPLRYSAILTSQ----VIAQIGLAIVLRAL 129
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
22-297 9.52e-10

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 58.71  E-value: 9.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL--GFCTDFHSCLfLACFVLVLTQ-SSIFSLLA 98
Cdd:cd15400   15 ILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFhnGWALGEMHCK-VSGFVMGLSViGSIFNITG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTP--FLGwndrkiatnctepgdaATNVSCCLIRCLFENVV 176
Cdd:cd15400   94 IAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTV-VAIVPnfFVG----------------SLEYDPRIYSCTFVQTA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRTELMDHSRtVLQREIHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15400  157 SSSYTIAVVVIHFIV-PITVVSFCYLRIWVLVIQVRRKVKSESKPR-LKPSDFRNFLTMFVVFVIFAICWAPLNLIGLAV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 257 LFQPTWAKVK-PKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15400  235 AINPQEMAPKvPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
24-300 1.40e-09

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 57.94  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADvAVGLFAIPFAVTISLGFCTDFHSCLFLACFVL--VLTQSSIFSLLAVAV 101
Cdd:cd15973   17 GNSMVIFVILRYAKMKTATNIYILNLAIAD-ELFMLSVPFLAASAALQHWPFGSAMCRTVLSVdgINMFTSVFCLTVLSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWNDRK------IATNCTEPGDAATNVscclirclfenv 175
Cdd:cd15973   96 DRYIAVVHPLRAARYRRPTVAKMINICVWILSL-LVISPIIIFADTAtrkgqaVACNLIWPHPAWSAA------------ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 vpmsYMVYFNFFGCVLPPLLIML---VIYVKIFLVACR---QLQRTELMDHSRTVLqreihaakslaLIVGIFALCWLPV 249
Cdd:cd15973  163 ----FVIYTFLLGFLLPVLAIGLcyiLIIGKMRAVALKagwQQRRKSEKKITRMVL-----------MVVTVFVICWMPF 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 250 HTINCASLFQPTWAKVkpkwAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15973  228 YVVQLLNLFLPRLDAT----VNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
22-297 1.45e-09

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 57.86  E-value: 1.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLvSLAAADVAVGLfAIPFAVT---ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15115   15 VPGNGLVIWVAGLKMKRTVNTIWFL-NLAVADLLCCL-SLPFSIAhllLNGHWPYGRFLCKLLPSIIVLNMFASVFTLTA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGwndRKIATNCTepgdaatnvsccLIRCLFENVVPM 178
Cdd:cd15115   93 ISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIY---RTTVTDGN------------HTRCGYDFLVAI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SymVYFNFFGCVLPpLLIMLVIYVKIflvaCRQLQRTELMDHSRTVLQREIhaakslaLIVGIFALCWLPVHTINCASLF 258
Cdd:cd15115  158 T--ITRAVFGFLLP-LLIIAACYSFI----AFRMQRGRFAKSQSKTFRVII-------AVVVAFFVCWAPYHIIGILSLY 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 121957962 259 -QPTWAKVKPKWAiNTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15115  224 gDPPLSKVLMSWD-HLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
22-300 1.46e-09

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 58.21  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQ--SSIFSLLAV 99
Cdd:cd15192   15 IFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNlyASVFLLTCL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNctepgdaaTNVSCCLIR---CLFENVV 176
Cdd:cd15192   95 SIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASL-PAIIHRDVFFIEN--------TNITVCAFHypsQNSTLLV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVyfNFFGcVLPPLLIMLVIYVKIF--LVACRQLQRTElmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTINC 254
Cdd:cd15192  166 GLGLMK--NLLG-FLIPFLIILTCYTLIGkaLKKAYEIQRNK---------PRNDEIFKMIMAVVLFFFFCWIPHQIFTF 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 255 AS-LFQPTWAKVKP-----KWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15192  234 LDvLIQLKVIQDCHiadivDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-300 1.53e-09

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 58.32  E-value: 1.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  38 LQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGF----------CTDFHsclFL--ACfvlvlTQSSIFSLLAVAVDRYL 105
Cdd:cd15355   34 LQSTVHYHLASLALSDLLILLLAMPVELYNFIWVhhpwafgdaaCRGYY---FLrdAC-----TYATALNVASLSVERYL 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 106 AVRVPLRYKSLVTGARARGVIAALWVLAFGIGlTPFL---GWNDRKIATN----CTEPGDAATNVSCCLIRCLFENVVPM 178
Cdd:cd15355  106 AICHPFKAKSLMSRSRTKKFISAIWLASALLA-IPMLftmGEQNRSGTHPggliCTPIVDTSTLKVVIQVNAFLSFLFPM 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNffGCVLPPLLIMLVIYVKIFLVACRQLQRTEL-MDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASL 257
Cdd:cd15355  185 LVISVLN--TLIANQLTVMVNQAEQENQVCTIGGQRTVLsVSMEPGRVQSLRHGVLVLRAVVIAFVVCWLPYHVRRLMFC 262
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 258 FQPTWAKVKP-----KWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15355  263 YVSDEQWTTFlydfyHYFYMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
22-300 1.55e-09

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 58.01  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15123   15 ILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATryIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTpflgwndRKIATNCTEPGDAATNVScclirclFENVVPM- 178
Cdd:cd15123   95 SADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIP-------EAVFSDLYSFRDPEKNTT-------FEACAPYp 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 ----------SYMVYFNFFgcvLPPLLIMLVIYvkiFLVAcRQLQR------TELMDHSRTVLQREIHAAKSLALIVGIF 242
Cdd:cd15123  161 vsekilqeihSLLCFLVFY---IIPLSIISVYY---FLIA-RTLYKstfnmpAEEHSHARKQIESRKRVAKTVLVLVALF 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121957962 243 ALCWLPVHTINCASLFQPTWAKVKPKWAINTAIL---LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15123  234 AFCWLPNHILYLYRSFTYHTSVDSSAFHLIATIFsrvLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
25-300 1.63e-09

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 57.94  E-value: 1.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDR 103
Cdd:cd15211   17 NVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQeAVLGSTGTLLVLGYRLFREGLLFLGLTVSLLSHSLIALNR 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 104 YLAV-RVPLRYKSLVTGARARGVIAALWVLAFGIgLTPFLGWNDRKIATnctepgdaatnVSCCLIRCLFENVVPMSYMV 182
Cdd:cd15211   97 YVLItKLPAVYQALYQKRNTEWMIALSWALALGL-LLPWLTSFRYPTKS-----------CHDSADGSFAVVSVLSSRYP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 183 YFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMD--------HSRTVLQREIhaAKSLALIVGIFALCWLPVHTINC 254
Cdd:cd15211  165 ALLLAFTVLGQTALVLHCYFGIFRRVQISVKRVSVLNfqivnnlpYSRPRKDKRL--GLYVLLVCCVFLLTTEPLVWVSL 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 255 ASLFQPTwakvkpKWAINTAI-LLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15211  243 AGLFVPV------PVALQTASwLLFCTLFVLNPFLYTWKNEEFRRSF 283
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
24-300 2.10e-09

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 57.44  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAvtislgFCTDFHSCLFLACF--------VLVLTQSSIFS 95
Cdd:cd15000   16 GNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMF------LVHDFFQNYVLGSVgcklegflEGSLLLASVLA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  96 LLAVAVDRYLAVRVPLRYKSLVTGARArgVIAALWVLAFGIGL--TPFLGWNDRK----IATNCTEpgdaatNVScclir 169
Cdd:cd15000   90 LCAVSYDRLTAIVLPSEARLTKRGAKI--VIVITWIVGLLLALplAIYRSYRERQwknfLETYCAE------NTQ----- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 clfenVVPMSYMVYFNFFgcVLPPLLIMLVIYVKIFLvacrQLQRTElmdhsRTVLQREIH--------AAKSLALIVGI 241
Cdd:cd15000  157 -----VLPIYWHVIITVL--VWLPLGIMLICYSAIFW----KLDKYE-----RRVLRREHPsvvrykkkAAKTLFIVLIT 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 242 FALCWLPVHTI--------NCASLFQPTWAKVKPKWAINTAILLshANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15000  221 FVVCRIPFTALifyryklvPNDNTQNSVSGSFHILWFASKYLMF--LNAAVNPLIYGFTNENFRKAF 285
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
44-249 2.38e-09

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 57.26  E-value: 2.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  44 YFLVS-LAAADVAVGLFAIPFAVTISL-GFCTDF--HSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTG 119
Cdd:cd14981   38 YRLVAgLAITDLLGILLTSPVVLAVYAsNFEWDGgqPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKK 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 120 ARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTepgdaatnvsCCLIRCLFENVVPMSYMVYFNFFGCVLppLLIMLV 199
Cdd:cd14981  118 RRARLMLGAVWAFALLIASLPLLGLGSYVLQYPGT----------WCFLDFYSKNTGDAAYAYLYSILGLLI--LLVTLL 185
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 200 IYVKIFLVACRQLQRTELMDHSRTVLQR----EIHAAKSLALIVGIFALCWLPV 249
Cdd:cd14981  186 CNLLVIITLLRMRRRKKRHRRSRRSARRqkrnEIQMVVLLLAITVVFSVCWLPL 239
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
21-297 2.51e-09

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 57.16  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFA----VTISLGFCTDFhsCLFLACFVLVLTQSSIFSL 96
Cdd:cd15404   14 SFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFAlvtiITTRWIFGDAF--CRVSAMFFWLFVMEGVAIL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVrvpLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEpgdaatnvscclirCLFENVV 176
Cdd:cd15404   92 LIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIPSRAPQ--------------CVFGYTT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFnffgcvlppLLIMLVIYVKIFLVACrqlqrTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15404  155 NPGYQAYV---------ILIMLIFFFIPFMVML-----YSFMGILNTVRSFKTRAFTTILILFIVFTVCWAPFTTYSLVA 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 257 LFQPTWAKVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15404  221 TFNSHFYHKHNFFEISTWLLwLCYLKSALNPLIYYWRIKKFR 262
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
23-289 4.49e-09

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 56.52  E-value: 4.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  23 TGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVtislgfctDFHSCL--------FLACFVLVLTQSSIF 94
Cdd:cd15204   16 VGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEM--------DYYVVRqrswthgdVLCAVVNYLRTVSLY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  95 ----SLLAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIGLTPflgwndrkiATNCTE-PGDAATNVSCCLIR 169
Cdd:cd15204   88 vstnALLVIAIDRYLVIVHPLKPR--MKRRTACVVIALVWVVSLLLAIPS---------AVYSKTtPYANQGKIFCGQIW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 CLFENVVPMSYMVyFNFFGCVLPPLLIMLVIYVKIFL-VACRQL--QRTELMdhsRTVLQREIHAAKSLALIVGIFALCW 246
Cdd:cd15204  157 PVDQQAYYKAYYL-FLFVLEFVLPVLIMTLCYLRIVRkVWFRRVpgQQTEQI---RRRLRRRRRKVRLLVVILTAFVLCW 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 247 LPVHTINCASLFQPTwakVKPKWAINTAIL-----LSHANSAVNPIVY 289
Cdd:cd15204  233 APYYGYAIVRDFFPT---LLSKEKLNTTIFyiveaLAMSNSMINTVVY 277
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
23-300 5.63e-09

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 56.30  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  23 TGNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPF-AVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15191   16 LGNSLVVCVFCHQSGPKTVASIYIFNLAVADL-LFLATLPLwATYYSYGYNWLFGSvmCKICGSLLTLNLFASIFFITCM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSlVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNctepgdaatNVSCCLIRCLFENVVPMS 179
Cdd:cd15191   95 SVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEEL---------GVNACIMAFPNEKYAQWS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 Y-MVYFNFFGCVLPPLLIMLVIYVKIFlvacRQLQRTELMDHSRtvlQREIHAAKSLALIVGIFALCWLPVHTINcaslF 258
Cdd:cd15191  165 AgLALMKNTLGFLIPLIVIATCYFGIG----RHLLKTKGFGKNK---QRRDKVLKMVAAVVLAFLICWFPFHVLT----F 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAKVK------PKWAINTA----ILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15191  234 LDALARMGvinncwVITVIDKAlpfaICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
21-297 1.06e-08

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 55.15  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTnyFLVSLAAADVAVGLFAIPFAVTISLGFctdFHSCLF--LACFVLV-----LTQSSI 93
Cdd:cd15220   13 ALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGILSSSPF---FLGVVFgeAECRVYIflsvcLVSASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndrkiatncTEPGDAATNVSCCLIRCLFE 173
Cdd:cd15220   88 LTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGW---------PSYGGPAPIAARHCSLHWSH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVVPMSYMVYFNFFgCVLPPLLIMLVIYVKIFLVACRQlqrtelmdhsrtvlqreiHAAKSLALIVGIFALCWLPVHtin 253
Cdd:cd15220  159 SGHRGVFVVLFALV-CFLLPLLLILVVYCGVFKVFGGG------------------KAALTLAAIVGQFLCCWLPYF--- 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 121957962 254 CASLFQPTWAKVKPKWAINTAIL-LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15220  217 AFHLYSALAASPVSGGEAEEVVTwLAYSCFAVNPFFYGLLNRQIR 261
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
40-250 1.11e-08

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 55.35  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  40 TPTNYFLVSLAAADVAVgLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTG 119
Cdd:cd15164   33 TETRVYMINLAVADCCL-LFSLPFVLYFLKHSWPDDELCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSP 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 120 ARARGVIAALWVLAfgigltpflgwndrkIATNCTEPGDAATNVSCCLIRclfENVVPMSYMVYFNFFGcVLPPLLIMLV 199
Cdd:cd15164  112 RKAALTCGLLWVLV---------------IISVSLRLAWEEQEENFCFGK---TSTRPSKRTLIFSLLG-FFIPLIILSF 172
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 200 IYVKIFlvacRQLQRTELMD-HSRTVLQREIHAAkSLALIVgiFALCWLPVH 250
Cdd:cd15164  173 CSIQVI----RSLKKKKKTNpHEEKLIQKAIYIV-SANLIV--FIVCFLPLH 217
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
77-298 1.24e-08

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 55.08  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  77 SCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFlgWNDRKIATNctep 156
Cdd:cd15160   72 SCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFL--GHDELFRDE---- 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 157 gdaaTNVSCClirclFENVVPMSYMV---YFNFFGCVLPPLLIMLVIYVKIFLvACRQLQRTElmdhsrtvLQREIHAAK 233
Cdd:cd15160  146 ----PNHTLC-----YEKYPMEGWQAsynYARFLVGFLIPLSLILFFYRRVLR-AVRQSPSLE--------REEKRKIIG 207
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121957962 234 SLALIVGIFALCWLPVHTINC----ASLFQP---TWAKvKPKWAINTAILLSHANSAVNPIVYAYRNRDFRY 298
Cdd:cd15160  208 LLLSIVVIFLLCFLPYHVVLLvrsvIELVQNglcGFEK-RVFTAYQISLCLTSLNCVADPILYIFVTEDVRQ 278
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
21-300 1.27e-08

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 54.85  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLG--FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15215   13 SLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPlfWPLDSHLCTALVVLMHLFAFAGVNTIVV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWndrkiatnctepGDAATNVSCCLIRCLFENVVPM 178
Cdd:cd15215   93 VSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGW------------GQAAFDERNALCSVIWGSSYSY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFNFFgcvLPPLLIMLVIYVKIFLVACRQLQrtelmdhsrtvlqreIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15215  161 TILSVVSSF---VLPVIIMLACYSMVFRAARRCYH---------------CKAAKVIFIIIFSYVLSMGPYSFLSVLAVW 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 259 QPTWAkvkPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15215  223 VDTQV---PQWVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
21-140 1.59e-08

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 54.80  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPfavTISLGFCTDFHSCLFLAC-----FVLVLTQSSIFS 95
Cdd:cd13954   14 TLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVP---KMLANLLSGDKTISFSGCltqlyFFFSLGGTECFL 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 121957962  96 LLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTP 140
Cdd:cd13954   91 LAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIH 135
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
21-300 1.77e-08

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 54.59  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADvavGLFA--IPF-AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15178   14 SLPGNSLVVLVILYNRRSRSSTDVYLLHLAIAD---LLFAltLPFwAVSVVKGWIFGTFMCKLVSLLQEANFYSGILLLA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVrvpLRYKSLVTGARA--RGVIAALWVLAFGIGLtPFL-----GWNDRKIATNCTEPGDAATNVSCCLIRC 170
Cdd:cd15178   91 CISVDRYLAI---VHATRALTQKRHlvKFVCAGVWLLSLLLSL-PALlnrdaFKPPNSGRTVCYENLGNESADKWRVVLR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 LFENVvpmsymvyFNFFgcvlPPLLIMLVIY----VKIFLVACRQLQRtelmdhsrtvlqreihAAKSLALIVGIFALCW 246
Cdd:cd15178  167 ILRHT--------LGFL----LPLVVMLFCYgftiKTLLQTRSFQKHR----------------AMRVIFAVVLAFLLCW 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 247 LPVHTincaSLFQPT--WAKVKP-----KWAINTAI----LLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15178  219 LPYNV----TVLIDTlmRTKLITetcelRNHVDVALyvtqILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
22-300 1.92e-08

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 54.81  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVTI----SLGFCTDFhSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15921   15 LTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLL-VCTLPLRLTYyvlnSHWPFGDI-ACRIILYVLYVNMYSSIYFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLaFGIGLTPFL---GWNDRKIATNCTEPGDAATnvscclirclfEN 174
Cdd:cd15921   93 ALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWIL-MGLASSPLLfakSKQHDEGSTRCLELAHDAV-----------DK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 175 VVPMSYMVYfnFFGCVLPpllIMLVIYVKIFLVacRQLQRTELMDHSRTVLQReihaaKSLALIV---GIFALCWLPVHT 251
Cdd:cd15921  161 LLLINYVTL--PVGFVVP---FMTVIFCYIFII--KNLLKPSPALGRTRPSRR-----KACALIIislGIFLVCFLPYHI 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 252 INcaSLFQPTWAKVKP----KWAINTAILLSH----ANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15921  229 VR--TIHLITERQIKEscgyILRVRKAAVITLclaaSNSCFDPLLYFFVGENFRSRL 283
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
22-295 1.99e-08

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 54.41  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVtISLGFCTDFH---SCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd14975   15 LPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAV-LLTLPVWI-YFLATGTWDFglaACKGCVYVCAVSMYASVFLITL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLA--FGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLircLFENVV 176
Cdd:cd14975   93 MSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAvlLATPVIAFRHVEETVENGMCKYRHYSDGQLVFHL---LLETVV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 pmsymvyfnffGCVLpPLLIMLVIYVKIFlvacRQLQRTELMDHSRTvlqreihaAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd14975  170 -----------GFAV-PFTAVVLCYSCLL----RRLRRRRFRRRRRT--------GRLIASVVVAFAACWLPYHVGNLLE 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 257 LFQPTWAKVKPKWAI--------NTAILLSHANSAVNPIVYAYRNRD 295
Cdd:cd14975  226 VVSELIGGSKMAGTLgkvaeagrPIAGALAFLSSSINPLLYAFAARG 272
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
21-297 2.04e-08

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 54.47  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGL--FAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15085   14 SIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALcgTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSLTL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAaLWVLAFGIGLTPFLGWNDRKiatnctePGDAATNVSCCLIRCLFENvvpM 178
Cdd:cd15085   94 LAYERYNVVCKPMGGLKLSTKRGYQGLLF-IWLFCLFWAVAPLFGWSSYG-------PEGVQTSCSIGWEERSWSN---Y 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 179 SYMVYFnFFGCVLPPLLIMLVIYVKIfLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLF 258
Cdd:cd15085  163 SYLILY-FLMCFVIPVAIIGFSYGNV-LRSLHKLNKKIEQQGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALIVVV 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 121957962 259 QPtwAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15085  241 NP--ELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
21-300 2.62e-08

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 54.30  E-value: 2.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIpfAVTISLGFCTDFHSCLFLaCFVLVLTQ-----SSIFS 95
Cdd:cd14986   14 TLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTV--LTQIIWEATGEWVAGDVL-CRIVKYLQvvglfASTYI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  96 LLAVAVDRYLAVRVPLryKSLVTGARARGVIAALWVLAFgIGLTP----FLGWNDRKIATNCTEPGDAATNvscclircl 171
Cdd:cd14986   91 LVSMSLDRYQAIVKPM--SSLKPRKRARLMIVVAWVLSF-LFSIPqlviFVERELGDGVHQCWSSFYTPWQ--------- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 fenvvPMSYMVYFNFFGCVLpPLLIMLVIYVKIFLV---ACRQLQRTEL---MDHSRTVLQR----------EIHAAKSL 235
Cdd:cd14986  159 -----RKVYITWLATYVFVI-PLIILSYCYGRILRTiwiRSRQKTDRPIaptAMSCRSVSCVssrvslisraKIKTIKMT 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 236 ALIVGIFALCWLPVHTINCASLFqpTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14986  233 LVIILAFILCWTPYFIVQLLDVY--AGMQQLENDAYVVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
22-297 3.00e-08

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 53.97  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLvSLAAADVAVGLFaIPFAV-TISLGFCTDFH--SCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15117   15 TLGNGLVIWVTGFRMTRTVTTVCFL-NLAVADFAFCLF-LPFSVvYTALGFHWPFGwfLCKLYSTLVVFNLFASVFLLTL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNCTE-------PGDAATNVSCCLircl 171
Cdd:cd15117   93 ISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSG-PHLVFRDTRKENGCTHcylnfdpWNETAEDPVLWL---- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 fENVVPM-SYMVYFNFFGCVLPPLLIMLVIYvkiFLVACRqLQRTELMDHSRTVlqreihaaKSLALIVGIFALCWLPVH 250
Cdd:cd15117  168 -ETVVQRlSAQVITRFVLGFLVPLVIIGGCY---GLIAAR-LWREGWVHSSRPF--------RVLTAVVAAFFLCWFPFH 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 251 TIncasLFQPTWAKVKPKWAINTAIL--------LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15117  235 LV----SLLELVVILNQKEDLNPLLIlllplsssLACVNSCLNPLLYVFVGRDFR 285
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
39-285 3.22e-08

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 54.00  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  39 QTPTNYFLVSLAAADVAVGLFaIPFA-VTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLV 117
Cdd:cd15923   32 WTETNIYMTNLAVADLLLLIS-LPFKmHSYRRESAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRARELR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 118 TGARARGVIAALWVLAFGIGLTPFLgwndrkiatnctePGDAATNVSCclirclFENVV---PMSYMVYFNFFGCVLpPL 194
Cdd:cd15923  111 SPRKAAVVCAVIWVLVVTISIPYFL-------------LDSSNEKTMC------FQRTKqteSLKVFLLLEIFGFLL-PL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 195 LIMLVIYVKiflVACRQLQRteLMDHSRTVLQREIHAAKSLALIVgiFALCWLPVHTINCASLFQPTWAKVKPKWAINTA 274
Cdd:cd15923  171 IIMTFCSAR---VIHTLQKR--LDDVGSRSETKQCIRVIMANLIV--FIVCFLPVHVGFFVKFIVGKSYSCDSKLIIHFF 243
                        250
                 ....*....|.
gi 121957962 275 ILLSHANSAVN 285
Cdd:cd15923  244 LQSAFCLSDMN 254
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
24-300 3.33e-08

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 53.99  E-value: 3.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADvavglfaipFAVTISLGFCTDFH----------SCLFLACFVLVLTQS-S 92
Cdd:cd14991   17 GNVVALWIFCFHSRTWKANTVYLFNLVLAD---------FLLLICLPFRIDYYlrgehwifgeAWCRVNLFMLSVNRSaS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGwndrkiatncTEPGDAATNVSCcliRCLF 172
Cdd:cd14991   88 IAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLS----------TLLTVNSNKSSC---HSFS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYFN--FFGCVLPPLLIMLVIYVKIFLVACRqlqRTELMDHSRtvLQReihAAKSLALIVGIFALCWLPVH 250
Cdd:cd14991  155 SYTKPSLSIRWHNalFLLEFFLPLGLIVFCSVRIACNLRI---RQSLGKQAR--VQR---AIRLVFLVVIVFVLCFLPSI 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 251 TINCASLFQPtwaKVKPKWAINTAILLSHA-------NSAVNPIVYAYRNRDFRYTF 300
Cdd:cd14991  227 IAGLLALVFK---NLGSCRCLNSVAQLFHIslaftylNSALDPVIYCFSSPWFRNSL 280
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
91-297 4.36e-08

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 53.48  E-value: 4.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWNDRKIATNCTEPGDAATNVscclirc 170
Cdd:cd15168   86 GSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVL-LQLLPILFFATTGRKNNRTTCYDTTSPE------- 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 LFENVVPMSYMVYFNFFGCvlpPLLIMLVIYVKIFLVACRQLQrtelmdHSRTVLQREiHAAKSLALIVGIFALCWLPVH 250
Cdd:cd15168  158 ELNDYVIYSMVLTGLGFLL---PLLIILACYGLIVRALIRKLG------EGVTSALRR-KSIRLVIIVLALFAVCFLPFH 227
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 251 ---TINCASLFQPTWAKVKPKWAINTAIL----LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15168  228 vtrTINLAARLLSGTASCATLNGIYVAYKvtrpLASLNSCLNPLLYFLAGDKFR 281
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
22-297 4.50e-08

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 53.61  E-value: 4.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLvSLAAADVAVGLFaIPFAVT-ISLGFCTDFHSCLF-LACFVLVLTQ-SSIFSLLA 98
Cdd:cd15116   15 VLGNGLVIFITGFKMKKTVNTVWFL-NLAVADFLFTFF-LPFSIAyTAMDFHWPFGRFMCkLNSFLLFLNMfTSVFLLTV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIG--------LTPFLGWNDRKIATNCTEPGDAATNVSCCLIRC 170
Cdd:cd15116   93 ISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSspsfifrdTAPSQNNNKIICFNNFSLSGDNSSPEVNQLRNM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 LFENVVPMSYMVYFnffgcvLPPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVlqreihaaKSLALIVGIFALCWLPVH 250
Cdd:cd15116  173 RHQVMTITRFLLGF------LIPFTIIICCYAAIVL----KLKRNRLAKSSKPF--------KIIAAVIVTFFLCWAPYH 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 251 TINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15116  235 ILNLLEMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFK 281
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
22-300 6.04e-08

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 53.28  E-value: 6.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSAL---QTPTNYFLVSLAAADVAVgLFAIPFAVTISLG---FCTDFHSCLFLACFVLVLTQSSIFS 95
Cdd:cd15338   15 IIGNSIVIYTIVKKSKFrcqQTVPDIFIFNLSIVDLLF-LLGMPFLIHQLLGngvWHFGETMCTLITALDTNSQITSTYI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  96 LLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWndrkiATNCTEPGDAatnVSCCLIrcLFENV 175
Cdd:cd15338   94 LTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSL-LSITPVWMY-----AGLMPLPDGS---VGCALL--LPNPE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLvacrQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd15338  163 TDTYWFTLYQFFLAFALPLVVICVVYFKILQ----NMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLA 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 256 SLF--QPTWAKVkpkWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15338  239 HLSidRPSLAFL---YAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
22-300 6.76e-08

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 52.99  E-value: 6.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15977   15 IIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIklIAEDWPFGVHVCKLYPFIQKASVGITVLSLCAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEpgdaatnvsccLIRCLFENVVPMS 179
Cdd:cd15977   95 SIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEIDYRGQT-----------LLVCMLPMEQTSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVY---------FNFFGCVlpPLLIMLVIYVkifLVACRQLQ-----RTELMDHSRTvlQREIhaAKSLALIVGIFALC 245
Cdd:cd15977  164 FMRFyqdvkdwwlFGFYFCL--PLACTGVFYT---LMSCEMLSikngmRIALNDHMKQ--RREV--AKTVFCLVVIFALC 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 246 WLPVHTincASLFQPTWAKVK-PKWAINTAILL---------SHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15977  235 WLPLHL---SRILKKTIYDVKdPQRCELLSFLLvmdytginmASLNSCINPVALYFVSRKFKNCF 296
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
24-297 6.81e-08

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 52.91  E-value: 6.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLflaCFVLVLTQS-----SIFSLLA 98
Cdd:cd15396   17 GNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETM---CKLTSFVQSvsvsvSIFSLVL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIaTNCTEPGDAATNVSCCLIR--CLFENVV 176
Cdd:cd15396   94 IAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQLTDEPF-RNLSSHSDFYKDKVVCIEAwpSETERLI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGcvlpPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA- 255
Cdd:cd15396  173 FTTSLLVFQYFV----PLGFIFICYLKIFVCLKKRNSKIDRMRENESRLSENKRINTMLISIVVTFAACWLPLNIFNVVf 248
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 256 SLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15396  249 DWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
24-297 7.02e-08

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 52.99  E-value: 7.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVavgLFAI--PF-AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd14984   17 GNSLVLLVLLYYRKLRSMTDVYLLNLALADL---LFVLtlPFwAVYAADGWVFGSFLCKLVSALYTINFYSGILFLACIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 101 VDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFlgwndrkIATNCTEPGDAATnvsCCLIrclFENVVPMSY 180
Cdd:cd14984   94 IDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEF-------IFSQVSEENGSSI---CSYD---YPEDTATTW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 181 MVYFNF----FGCVLpPLLIMLVIYVKIF--LVACRQLQRTElmdhsrtvlqreihAAKSLALIVGIFALCWLP------ 248
Cdd:cd14984  161 KTLLRLlqniLGFLL-PLLVMLFCYSRIIrtLLRARNHKKHR--------------ALRVIFAVVVVFFLCWLPynivll 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 249 VHTINCASLFQPTWA--KVKPKWAINTAIL-LSHanSAVNPIVYAYRNRDFR 297
Cdd:cd14984  226 LDTLQLLGIISRSCElsKSLDYALQVTESLaFSH--CCLNPVLYAFVGVKFR 275
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
21-289 8.26e-08

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 52.76  E-value: 8.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLV-CAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPF--AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15383   14 SACSNLAVlWSATRNRRRKLSHVRILILHLAAADLLVTFVVMPLdaAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFVTV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLryKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIAtnctepgdAATNVSCCLIRCLF----- 172
Cdd:cd15383   94 VISLDRHAAILNPL--AIGSARRRNRIMLCAAWGLSALLALPQLFLFHTVTAT--------PPVNFTQCATHGSFpahwq 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMsymvyFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQR--------EIHAAKSLALIVGIFAL 244
Cdd:cd15383  164 ETLYNM-----FTFFCLFLLPLLIMIFCYTRILLEISRRMKEKKDSAKNEVALRSssdnipkaRMRTLKMTIVIVSSFIV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 245 CWLPVHTINCASLFQPTWAKVK-PKWAINTAILLSHANSAVNPIVY 289
Cdd:cd15383  239 CWTPYYLLGLWYWFSPEMLEQTvPESLSHILFLFGLLNACLDPLIY 284
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
21-120 8.54e-08

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 52.68  E-value: 8.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIslgFCTDFHSCLFLACFV-------LVLTQSSI 93
Cdd:cd15917   14 ALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGI---FWFNAREISFDACLAqmffihsFTAMESGV 90
                         90       100
                 ....*....|....*....|....*..
gi 121957962  94 fsLLAVAVDRYLAVRVPLRYKSLVTGA 120
Cdd:cd15917   91 --LLAMAFDRYVAICYPLRYTTILTNT 115
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
22-300 8.90e-08

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 52.51  E-value: 8.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLflaCFVLVLTQS-----SIFSL 96
Cdd:cd15399   15 VVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVL---CHLVPYAQAlavhvSTVTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIG--LTPFLGWNDRKIATN-----CTEPGDAATNVSCCLIR 169
Cdd:cd15399   92 TVIALDRHRCIVYHLESK--ISKKISFLIIGLTWAASALLAspLAIFREYSVIEISPDfkiqaCSEKWPNGTLNDGTIYS 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 clfenvVPMSYMVYfnffgcvLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRtvlQREIHAAKSLALIVGIFALCWLPV 249
Cdd:cd15399  170 ------VSMLLIQY-------VLPLAIISYAYIRIWTKLKNHVSPGGGNDHYH---QRRRKTTKMLVCVVVVFAVSWLPF 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 250 HTINCASLFQPTWAKVKPKWAINTAI-LLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15399  234 HAFQLASDIDSKVLDLKEYKLIYTIFhVIAMCSTFANPLLYGWMNNNYRTAF 285
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
21-134 9.35e-08

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 52.50  E-value: 9.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTD--FHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:pfam13853   8 IFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREisFEACLTQMFFIHKFSIMESAVLLA 87
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 121957962   99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:pfam13853  88 MAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSF 123
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
24-300 9.45e-08

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 52.56  E-value: 9.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSA---LQTPTNYFLVSLAAADVAVGLFAIPfavtISLGFCTDFH--------SCLFLACFVLVLTQSS 92
Cdd:cd15356   17 GNALTIHLVLKKRSlrgLQGTVHYHLVSLALSDLLILLISVP----IELYNFVWFHypwvfgdlVCRGYYFVRDICSYAT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGL-TPFLGWNDRKIATNCTEPGDAATNVSCCLIRCL 171
Cdd:cd15356   93 VLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALpMAFIMGQKYELETADGEPEPSSRVCTVLVSRAT 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 FENVVPMSYMVYFnffgcVLPPLLIMLVIYVKIFLVACRQLQrtelmdhsrtvlqreiHAAKSLALIVGIFALCWLPVHT 251
Cdd:cd15356  173 LKVFIQVNAFVSF-----VLPLALIAFLNGVTVSHLRIQSLQ----------------HSVQVLRAIVIAYVICWLPYHA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 252 INCASLFQPTWAKVKPKWAI--------NTailLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15356  232 RRLMFCYVPDDAWTDSLYNFyhyfymltNT---LFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
21-300 9.83e-08

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 52.64  E-value: 9.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGtsSALQTPTNYFLVSLAAADVAVGLFAIPFAVtisLGFCTDFHSCLF--LAC----FVLVL-TQSSI 93
Cdd:cd15130   19 SVTLFTLARKKSL--QSLQSTVRYHLGSLALSDLLILLLAMPVEL---YNFIWVHHPWAFgdAGCrgyyFLRDAcTYATA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVscCLIRCLFE 173
Cdd:cd15130   94 LNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESDDGTHPGGLVCTP--IVDTATLK 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 174 NVVPMSYMVYFnffgcVLPPLLIMLViyvkiflvacrqlqRTELMDHSRTVLQREIHAAKSlalIVGIFALCWLPVHTIN 253
Cdd:cd15130  172 VVIQVNTFMSF-----LFPMLVTSIL--------------NTVIANKLVQALRRGVLVLRA---VVIAFVVCWLPYHVRR 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121957962 254 CASLFQPTWAKVKPKW--------AINTailLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15130  230 LMFCYISDEQWTTFLFdfyhyfymLTNA---LFYVSSAINPILYNLVSANFRQVF 281
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
22-297 1.18e-07

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 52.17  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPFAV--TISLG-FCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15194   15 AVGNAILMGALVFKRGVRRLIDIFISNLAASDF-IFLVTLPLWVdkEVVLGpWRSGSFLCKGSSYIISVNMYCSVFLLTC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATN--CTEpgDAATNVSCclirclfenVV 176
Cdd:cd15194   94 MSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKeyCNE--DAGTPSKV---------IF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFgcvlpPLLIMLVIYVKIFLVACRQLQRTELMDHSrtvLQREIhaaKSLALIVGIFALCWLPVHT----- 251
Cdd:cd15194  163 SLVSLIVAFFL-----PLLSILTCYCTIIWKLCHHYQKSGKHQKK---LRKSI---KIVFIVVAAFVFSWMPFNLfkala 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 252 -INCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15194  232 iASGLQVEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIR 278
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
21-139 1.36e-07

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 51.85  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISlgfctdFHSCLFLACFVLVLTQSS 92
Cdd:cd15918   14 TVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLvniqtqskSIS------YAGCLTQMYFFLLFGDLD 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLT 139
Cdd:cd15918   88 NFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLL 134
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
22-297 1.47e-07

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 52.12  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVgTSSALQTPTNYFLVSLAAADVaVGLFAIPFAV-TISLGFCTDFHSclFLACFVLVLTQSSIFSLLAV- 99
Cdd:cd15339   15 LVGNILVLFTI-IRSRKKTVPDIYVCNLAVADL-VHIIVMPFLIhQWARGGEWVFGS--PLCTIITSLDTCNQFACSAIm 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 ---AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNctepgdaatnvsccLIRCLFENVV 176
Cdd:cd15339   91 tamSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDG--------------LESCAFNLTS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 P---MSYMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQRE--IHAAKSLALIVGIFALCWLPVHT 251
Cdd:cd15339  157 PddvLWYTLYQTITTFFF-PLPLILICYILILCYTWEMYRKNKKAGRYNTSIPRQrvMRLTKMVLVLVGVFLVSAAPYHV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 252 INCASL--FQPTWAKVkpkWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15339  236 IQLVNLsvSQPTLAFY---VSYYLSICLSYASSSINPFLYILLSGNFR 280
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
22-141 1.68e-07

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 51.91  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTD--FHSCL---FLACFVLVlTQSSIfsL 96
Cdd:cd15221   15 LLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEisFDGCLtqmFFVHFVFV-TESAI--L 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 121957962  97 LAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIgLTPF 141
Cdd:cd15221   92 LAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCI-VFPF 135
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
40-296 1.94e-07

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 51.62  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  40 TPTNYFLVSLAAADVaVGLFAIPFAVTISL---------GFC--TDFhsclflaCFVLVLtQSSIFSLLAVAVDRYLAVR 108
Cdd:cd15967   33 GNINVFVLNLGLADL-LYLLTLPFLVVYYLkgrkwifgqVFCkiTRF-------CFNLNL-YGSIGFLTCISVYRYLAIV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 109 VPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWNdrKIATNCTEPGDAATNvscclirclfENVvpMSYMVY---FN 185
Cdd:cd15967  104 HPMRVMGRITTTHSVVISALVWLLVV-IQSLPDLFFS--KTNSNGTKCFDTTFN----------DYL--ESYLTYslgWT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 186 FFGCVLPpLLIMLVIYVKIFLVACRQlqrtelmDHSRTVLQREihAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKV 265
Cdd:cd15967  169 VTGFVIP-LLIILGCYGHVVVVLCRN-------NNVDKGLKQR--CLKLVIILIVLFSVCYIPYHVFRNLNLLSRILQKQ 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 121957962 266 KPKWAINTAILLSHA--------NSAVNPIVYAYRNRDF 296
Cdd:cd15967  239 GSCTQWFRGIYIAHQvsrglvclNSALNPLVYLMGSEDI 277
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
21-289 2.14e-07

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 51.67  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP----FAVTISL----GFCTDFHsclFLACFVLVLtqsS 92
Cdd:cd15384   14 SFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPseaiWAYTVAWlagnTMCKLVK---YLQVFGLYL---S 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  93 IFSLLAVAVDRYLAVRVPLryKSLVTGARARGVIAALWVLAfGIGLTPflgwndrKIATNCTEPGDAATNVSCCLIRCLF 172
Cdd:cd15384   88 TYITVLISLDRCVAILYPM--KRNQAPERVRRMVTVAWILS-PIFSIP-------QAVIFHVERGPFVEDFHQCVTYGFY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 173 ENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLV---ACRQLQRTELMDHSRT-VLQREIHAAK--SL---ALIVGIFA 243
Cdd:cd15384  158 TAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITlskSSRDFQGLEIYTRNRGpNRQRLFHKAKvkSLrmsAVIVTAFI 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 244 LCWLPVHTINCASLF-QPTWAKVKPKWAIntaILLSHANSAVNPIVY 289
Cdd:cd15384  238 LCWTPYYVIMIWFLFfNPYPLNDILFDVI---FFFGMSNSCVNPLIY 281
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
21-134 2.18e-07

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 51.44  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISlgfctdFHSCLFLACFVLVLTQSS 92
Cdd:cd15226   14 TVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMIcdllrehkTIS------FGGCMAQIFFLHFFGGSE 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15226   88 MVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGF 129
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
40-297 2.40e-07

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 51.41  E-value: 2.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  40 TPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLV 117
Cdd:cd15925   34 PPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGamCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 118 TGARARGVIAALWVLAFGIgltpflgwndrKIATNCTEPGDAATNVSCCLIRclfenvVPMSYMVYFNFFGCVLPPLLIM 197
Cdd:cd15925  114 STFWAKIITLALWAAALLA-----------TVPTAIFATEGEVCGVELCLLK------FPSNYWLGAYHLQRVVVAFVVP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 198 LVIYVKIFLVACRQLQRTELMDHSRtvlQREIHAAKSLALIVGIFALCWLPVHTINCASLFQP----TWAKVkpKWAINT 273
Cdd:cd15925  177 LGVITTSYLLLLSFLQQHKVNQNNR---QRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKfravPWNST--FYFIHT 251
                        250       260
                 ....*....|....*....|....*....
gi 121957962 274 AIL-----LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15925  252 YVFpvttcLAHSNSCLNPVLYCLMRREFR 280
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
21-142 2.42e-07

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 51.23  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIS-LGFC-TDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15952   14 ALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFwFNLReISFGGCLAQMFFIHTFTGMESAVLVA 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTgARARGVIAALWVLAFGIGLTPFL 142
Cdd:cd15952   94 MAFDRYVAICNPLRYTTILT-NKVISVIALGIVLRPLLLVLPFV 136
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
21-121 2.56e-07

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 51.11  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIslgFCTDFHSCLFLACFV-------LVLTQSSI 93
Cdd:cd15953   14 TLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCI---FWFNLKEITFSGCLTqmffihtLSIMESAV 90
                         90       100
                 ....*....|....*....|....*...
gi 121957962  94 fsLLAVAVDRYLAVRVPLRYKSLVTGAR 121
Cdd:cd15953   91 --LVAMAFDRYVAICNPLRYATILTNSR 116
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
91-299 3.88e-07

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 50.55  E-value: 3.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKIATNCTEPGDAATNVSCCLIrc 170
Cdd:cd15129   88 ASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGI-PFYWWSDMWRDSHPPTTLDKVLKWTHCFI-- 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 lfenvvpmsymVYFnffgcvlPPLLIMLVIYVkifLVACRQLQRTELMDHSRTVlqreihaAKSLALIVGI---FALCWL 247
Cdd:cd15129  165 -----------IYF-------IPCTIFLVTNS---VIIHKLRRRKGRSGPQRRS-------GKTTAILLAIttvFAVLWA 216
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 248 PVhtiNCASLFQPTWAKVKPKW----AINTAILLSHANSAVNPIVYAYRNRDFRYT 299
Cdd:cd15129  217 PR---TVVIIYHLYVSSVNRDWrvhlALDLANMLAMLNTAVNFFLYCFVSKRFRRT 269
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
21-134 5.89e-07

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 50.30  E-value: 5.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15235   15 TLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPkmLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAV 94
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15235   95 MAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSH 130
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
22-129 7.22e-07

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 49.98  E-value: 7.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPfavTISLGFCTDFHSCLFLACFV-------LVLTQSSIf 94
Cdd:cd15223   15 LVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILP---KMLAIFWFDANTISLPGCFAqmffihfFTAMESSI- 90
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 121957962  95 sLLAVAVDRYLAVRVPLRYKSLVTGAR-ARGVIAAL 129
Cdd:cd15223   91 -LLVMALDRYVAICKPLRYPSIITKSFiLKLVLFAL 125
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
45-300 8.89e-07

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 49.76  E-value: 8.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  45 FLVSLAAADVavgLFAIPFAVTISLGFC-----TDFHSCLFLACFVLVLTQSSIFsLLAVAVDRYLAVRVPLRYKSLVTG 119
Cdd:cd15154   38 YMCNLALSDL---LFTLSLPLRIYYYANhywpfGNFLCQFSGSIFQMNMYGSCLF-LMCINVDRYLAIVHPLRFRHLRRP 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 120 ARARGVIAALWVLAFGIGLTPFLGWNdrkiATNCTEPGDAATNVSCCLIRCLFENVVPMSYMVYFNFFgcvLPPLLIMLV 199
Cdd:cd15154  114 KVARLLCLAVWALILGGSVPAAIVHS----SSDCLLHGEKVYRCFESFSDNDWKGLLPLVVLAEILGF---LLPLAAVLY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 200 IYVKIFLVACRQlQRTELMDHSRTVlqreihaaKSLALIVGIFALCWLP------VHTINCASLFQPTW-AKVKPKWAIN 272
Cdd:cd15154  187 CSCRIFVELCRT-QEPQQGRRRKTV--------RLLLVNLVIFLICFVPynttlaVYGLLRANLVEDTWnIKDTLRKVLS 257
                        250       260
                 ....*....|....*....|....*...
gi 121957962 273 TAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15154  258 VTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
21-130 1.02e-06

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 49.38  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAV-GTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15935   14 ILLGNLLIVVTVhADPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLAdlLTCGRTISFGGCMAQLFFLHFLGGSEMLLLT 93
                         90       100       110
                 ....*....|....*....|....*....|...
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALW 130
Cdd:cd15935   94 LMAYDRYVAICHPLRYLAVMNRQLCIKLLAACW 126
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
26-300 1.07e-06

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 49.32  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  26 VLVCAAVGTSSAL---------QTPTNYFLVSLAAADVAVgLFAIPFAVTISLgfcTDFH------SCLfLACFVLVLTQ 90
Cdd:cd15161   10 VFILAFPGNTLALwlfihdrksGTPSNVFLMHLAVADLSY-VLILPMRLVYHL---SGNHwpfgevPCR-LAGFLFYLNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 -SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAfGIGLTPFLGWNDRKIATNctepgdaaTNVSCCLIR 169
Cdd:cd15161   85 yASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIV-TVAMAPLLVSPQTVEVNN--------TTVCLQLYR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 CLFENVVPMSYMVYFnffgcvLPPLLIMLVIYVKIFLvACRQLQRTElmdhsrTVLQREihAAKSLALIVGIFALCWLPV 249
Cdd:cd15161  156 EKASRGALVSLAVAF------TIPFVTTVTCYLLIIR-SLRTGKREE------KPLKDK--AIKMIILVLTIFLICFVPY 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 250 HT-----INCASLFQPTwAKVKPKWAINTAIL--LSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15161  221 HIsryiyILSHNGAGAS-CSSRRGLALANRITscLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
21-142 1.13e-06

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 49.02  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP-----FAV---TISlgfctdFHSClFLACFVLVLTQSS 92
Cdd:cd15912   14 TLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPkmlanLLSgkkTIS------FAGC-FAQSFFYFFLGTT 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962  93 IFSLLAV-AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFL 142
Cdd:cd15912   87 EFFLLAVmSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTI 137
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
39-299 1.29e-06

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 49.02  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  39 QTPTNYFLVSLAAADVAVGlFAIP--FAVTISLGFCTdfhSCLFLACF-VLVLTQSSIFSLLAVAVDRYLAVRVPLRYKS 115
Cdd:cd15163   32 KTTSVIYTINLVVTDLLVG-LSLPtrIVMYYSAGNCL---TCSFVHIFsYFVNMYCSILFLTCICVDRYLAIVQVEASRR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 116 LVTGARARGVIAALWVLAfgigltpflgwndrkIATNCTEPGDAATNVSCCLIRCLFENVvpmsymvyFNFFgcvlPPLL 195
Cdd:cd15163  108 WRNPNYAKGICVFIWLFA---------------IVVTFSILTTAIKFASCCLSKLFALTV--------FEFF----LPLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 196 IMLVIYVKIFLVacrqLQRTELMDHSRtvlQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAI 275
Cdd:cd15163  161 IITFFTIRIMCA----LSRPGLMHQSR---ERRMRAVQLLITVLIIFMICFTPFHVRQVAVAFNPDIPHHTSLIVYHVTV 233
                        250       260
                 ....*....|....*....|....
gi 121957962 276 LLSHANSAVNPIVYAYRNRDFRYT 299
Cdd:cd15163  234 TLSSLNSCMDPIVYCFVTNNFQST 257
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
41-300 1.52e-06

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 49.02  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  41 PTNYFLVSLAAADVAVgLFAIPFAVTISL---------GFCTDFHSCLFLAcfvlvlTQSSIFSLLAVAVDRYLAVRVPL 111
Cdd:cd15199   34 PYAVYLLNLVLADVLL-LICLPFKAYFYLngnrwslggGTCKALLFMLSLS------RGVSIAFLTAVALDRYFRVVHPR 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 112 RYKSLVTGARARGVIAALWVLAfgIGLT-PFLGWNDRKIATNCTEPGDAATnvscclirclfENVVPMSYMVYFnFFGCV 190
Cdd:cd15199  107 GKKNSLSLQAAPYISFLVWLLL--VGLTiPTLLASQPKNFTECNSFSPKDD-----------EDFSDTWQEAVF-FLQFL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 191 LPpllIMLVIYVKIFLVacRQLQRTELMDHSRTVLQReihAAKSLALIVGIFALCWLPVHTincASLFQPTWAKVKPKWA 270
Cdd:cd15199  173 LP---FGLIVFCTVRII--RRLKKRLRDVGKQPKLQR---AMALVTSVVVVFGFCFLPCFL---ARVLMLIFQNKESCNA 241
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121957962 271 INTAI-------LLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15199  242 LNIAVhtydvtmCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
21-141 1.56e-06

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 48.88  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIsLGFCT---DFHSCL----FLACFVLVltQSSI 93
Cdd:cd15951   14 ALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSI-FWFNSreiDFSACLtqmfFIHSFSTM--ESGI 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962  94 FslLAVAVDRYLAVRVPLRYKSLVTGARARGvIAALWVLAFGIGLTPF 141
Cdd:cd15951   91 F--VAMALDRYVAICNPLRHSTILTNSVVAK-IGLAVVLRGGILVSPH 135
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
21-143 2.01e-06

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 48.37  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISLGFCtdfhscLFLACFVLVLTQSS 92
Cdd:cd15431   14 TLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLvnclsdrpTISYSRC------LAQMYISLFLGITE 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLG 143
Cdd:cd15431   88 CLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLT 138
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
21-139 2.30e-06

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 48.25  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15233   14 TIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVhlLSHKRTISYAACLSQLFFFHLLAGADCFLLTA 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLT 139
Cdd:cd15233   94 MAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALT 134
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
80-297 2.35e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 48.22  E-value: 2.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  80 FLACFvlvLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTpflgwndrkiATNCTEPGDA 159
Cdd:cd15219   78 FLETF---LTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLV----------ALFLSWLGYS 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 160 ATNVSCCL-IRCLFENVVPMSYMVYFNFFGCVLpPLLIMLVIYVKIFLVACRQlqrtelmdhsrtvlqreiHAAKSLALI 238
Cdd:cd15219  145 SLYASCTLhLPREEERRRFAVFTAFFHAFTFLL-SLLVLCVTYLKVLKVRRRQ------------------RATKKISIF 205
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 239 VGIFALCWLPVHTINCASLFQPTwaKVKPKWAInTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15219  206 IGTFVLCFAPYVITRLVELLPFV--TINRYWGI-VSKCLTYSKAASDPFVYSLLRQQYR 261
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
40-297 2.53e-06

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 48.21  E-value: 2.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  40 TPTNYFLVSLAAADVavgLFAIPFAVTISLGFCTD---FHS--CLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYK 114
Cdd:cd15162   33 APAVIYMANLAIADL---LLVIWLPFKIAYHIHGNnwiFGEalCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHR 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 115 SLVTGARARGVIAALWVLAFGIGLTPFLgwndRKIATNCTEPGdaatNVSCCLIRCLFENVVPMSYMVYFNFFGCVLPPL 194
Cdd:cd15162  110 RLRARRYALGTCLAIWLLALLVTLPLYL----VKQTIFLPALD----ITTCHDVLPEQLLVGDWFYYFLSLAIVGFLIPF 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 195 LIMLVIYVKIFlvacrqlqRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQP---TWAKVKPKWAI 271
Cdd:cd15162  182 ILTASCYVATI--------RTLAALEDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSLIsssGTGHLYFAYLL 253
                        250       260
                 ....*....|....*....|....*.
gi 121957962 272 ntAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15162  254 --ALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
41-297 2.68e-06

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 48.21  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  41 PTNYFLVSLAAADVAVgLFAIPFAVTISL---------GFCTDFHSCLF--LACFVLVLTqssifsllAVAVDRYLAVRV 109
Cdd:cd15372   33 PSTIFLINLAVADLLL-ILVLPFKISYHFlgnnwpfgeGLCRVVTAFFYgnMYCSVLLLM--------CISLDRYLAVVH 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 110 PLRYKSLVTGARARGVIAALWVLAfGIGLTPFlgwndrkIATNCTEPGDAATNVSCclirclfENVVPMSYMV--YFNFF 187
Cdd:cd15372  104 PFFARTLRSRRFALCMCTAIWLIA-AALTLPL-------TLQRQSYPLERLNITLC-------HDVLPLDEQDtyLFYYF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 188 GCV-----LPPLLIMLVIYVKIFLVACRQLQRTElmdhsrtvlqreiHAAKSLALIVGIFALCWLPVHT---INCASLFQ 259
Cdd:cd15372  169 ACLavlgfLLPLVVILFCYGSVLHTLLRSGQRYG-------------HAMKLTVLVLVSFVLCFTPSNLlllLHYSDPTL 235
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121957962 260 PTWAKVKPKWAINTAIllSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15372  236 DDGGNLYIVYMVSLAI--STLNSCVDPFIYYYVSEEFR 271
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
74-297 2.70e-06

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 48.33  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  74 DFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLvTGARARGVIAALWVLAFGIGLTP---------FLGW 144
Cdd:cd15965   76 DSTQCQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTP-GKCRTITILILIWIIGFIIAFIPlsnkeffrnYYGT 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 145 NDRKIATNCTEPGDAATNVSCCLIrclfenvvpmsymvyfnFFGCVLPPLLIMLVIYVKIFLVACRQ-LQRTELMDHsrt 223
Cdd:cd15965  155 NGVCFPLHSEQPESTGAQIYSVVI-----------------FLGLNLAAFIIIVFSYGSMFYSIHQTaIMATEISNH--- 214
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121957962 224 vLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAIntaILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15965  215 -IKKEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQVEIPGTISSWVV---IFILPINSALNPILYTLTTRPFK 284
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
38-297 2.99e-06

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 47.90  E-value: 2.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  38 LQTPTNYFLVSLAAAD--VAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKS 115
Cdd:cd15080   31 LRTPLNYILLNLAVADlfMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 116 LVTGARARGViAALWVLAFGIGLTPFLGWNdRKI--ATNCTEPGDAATnvscclircLFENVVPMSYMVYFNFFGCVLPP 193
Cdd:cd15080  111 FGENHAIMGV-AFTWVMALACAAPPLVGWS-RYIpeGMQCSCGIDYYT---------LKPEVNNESFVIYMFVVHFTIPL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 194 LLIMLVIYVKIFLVACRQLQRTElmdhSRTVLQREIHAAKSLALIVGIFALCWLPVHTI------NCASLFQPTWAKVKP 267
Cdd:cd15080  180 IVIFFCYGRLVCTVKEAAAQQQE----SATTQKAEKEVTRMVIIMVIAFLICWVPYASVafyiftHQGSDFGPIFMTIPA 255
                        250       260       270
                 ....*....|....*....|....*....|
gi 121957962 268 KWAINTAILlshansavNPIVYAYRNRDFR 297
Cdd:cd15080  256 FFAKSSAVY--------NPVIYILMNKQFR 277
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
25-297 3.02e-06

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 47.93  E-value: 3.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  25 NVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLF--AIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVD 102
Cdd:cd15084   28 NGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFgsSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 103 RYLAVRVPL-----RYKSLVTGArargviAALWVLAFGIGLTPFLGWND---RKIATNCTE---PGDAATNvscclircl 171
Cdd:cd15084  108 RYLVICKPMgdfrfQQRHAVSGC------AFTWGWSLLWTSPPLFGWSSyvpEGLRTSCGPnwyTGGTNNN--------- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 fenvvpmSYMVYFnFFGCVLPPLLIMLVIYVKIFL----VACRQLQrtelmdhSRTVLQREIHAAKSLALIVGIFALCWL 247
Cdd:cd15084  173 -------SYILAL-FVTCFALPLSTIIFSYSNLLLtlraVAAQQKE-------SETTQRAEKEVTRMVIAMVMAFLICWL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 248 P------VHTINCASLFQPTWAKVkPKWAINTAillshanSAVNPIVYAYRNRDFR 297
Cdd:cd15084  238 PyatfamVVATNKDVVIQPTLASL-PSYFSKTA-------TVYNPIIYVFMNKQFR 285
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
21-118 3.07e-06

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 47.85  E-value: 3.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIS-LGFC-TDFHSCLF----LACFVLVltQSSIF 94
Cdd:cd15949   30 AVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFwFSSNeIPLHACLLqmflIHSFSAI--ESGIF 107
                         90       100
                 ....*....|....*....|....
gi 121957962  95 slLAVAVDRYLAVRVPLRYKSLVT 118
Cdd:cd15949  108 --LAMAFDRYVAICNPLRHKTILT 129
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
21-141 3.55e-06

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 47.94  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAAD------VAVGLFAIPFAVTISLGFctdfHSCLFLACFVLVLTQSSIF 94
Cdd:cd15956   14 SLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDlvlalsTAPKLLAILWFGATAISS----YVCLSQMFLVHAFSAMESG 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962  95 SLLAVAVDRYLAVRVPLRYKSLVTGARArgVIAALWVLAFGIGLTPF 141
Cdd:cd15956   90 VLVAMALDRFVAICNPLHYATILTLEVV--AKAGLLLALRGVAIVIP 134
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
22-134 4.49e-06

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 47.25  E-value: 4.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISLGFCTD--FHSCLFLACFVLVLTqs 91
Cdd:cd15232   15 LTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLqnllterkTISFGGCMAqlYFFTWSLGSELLLLT-- 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 121957962  92 sifsllAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15232   93 ------AMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGM 129
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
21-134 4.68e-06

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 47.33  E-value: 4.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15936   14 TWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPkmLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSV 93
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15936   94 MAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGF 129
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
22-134 5.71e-06

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 47.05  E-value: 5.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15940   15 LSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSdlLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIM 94
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15940   95 AYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGT 129
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
24-297 7.54e-06

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 46.81  E-value: 7.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSAL-QTPTNYFLVSLAAADVAVGLfAIPF-AVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15926   17 GNLLVLYLMKSKQGWkKSSINLFVTSLAVTDFQFVL-TLPFwAVENALDFTWLFGKamCKIVSYVTAMNMYASVFFLTAM 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkIATNCTepgdaATNVSCCLIRcLFENVVPMS 179
Cdd:cd15926   96 SVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAI------FSTTAT-----VSNEELCLVK-FPDNRGNAQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRtvlQREIHAAKSLALIVGIFALCWLPVHTINCASL-- 257
Cdd:cd15926  164 FWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDKNITGSST---KRRSKVTKSVTIVVLSFFLCWLPNQALTTWGIli 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 258 ------FQPTWAKVKpKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15926  241 klnvvhFSYEYFTTQ-VYIFPITVCLAHSNSCLNPILYCLMRREFR 285
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
45-297 9.24e-06

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 46.67  E-value: 9.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  45 FLVSLAAADVAVgLFAIPFAVTISLG----FCTDFHsCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLryKSLVTGA 120
Cdd:cd15147   40 FMVNLTIADLLF-LITLPFWIVYYHNegnwILPKFL-CNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPI--KTAQSTT 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 121 RARGVI--AALWVLAFGIGLtPFLgwndrkIATNCTEPGDAATNVSCCLIRCLFENVVPmsyMVYFNFFGCVLPPLLIML 198
Cdd:cd15147  116 RKRGIIisVAIWVIIVASAS-YFL------FMDSTNTVKIDSGNFTRCFEGYEKDNSKP---VLIIHFIIIGLFFLVFLL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 199 VIYVKIFLVacrqlqRTELmdhSRTVLQREIHAAKSLAL-----IVGIFALCWLPVHTIncaslfQPTWA----KVKPKW 269
Cdd:cd15147  186 ILVCNLVIA------RTLL---SQPVQGQRNAGVKRRALwmvctVLAVFVICFVPHHVV------QGPWTlavlQQWRYW 250
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121957962 270 ------AINTA----ILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15147  251 dcqfrqALNDAhqitLCLMSTNCVLDPVIYCFLTKKFR 288
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
21-297 9.47e-06

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 46.40  E-value: 9.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISlgfcTDFHSCLFLACFVL---------VLTQS 91
Cdd:cd15006   13 SLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLS----ASPHCCWWIYTLLFckvikflhkVFCSV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIGLTPFlgwndrkIATNCTepgDAATNVSCCLIRCl 171
Cdd:cd15006   89 TVLSFAAIALDRYYSVLYPLERK--ISDAKSRDLVIYIWAHAVVASVPVF-------AVTNVT---DIYAMSTCTESWG- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 fENVVPMSYMVYFNFFGCVLPPLLIMLVIYV-----------KIFLVACRQLQRTELMDHsrtVLQREIHAAKSLALIVG 240
Cdd:cd15006  156 -YSLGHLVYVIIYNITTVILPVAVVFLFMILirralsasqkkKVIIAALRTPQNTISIPY---VSQREAELHAMLLSMVL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 241 IFALCWLPVHTINC-ASLFQPTWAKVkpkWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15006  232 VFILCSVPYATLVIyRTILNISDISV---FLLLTAIWLPKVSLLANPLLFLTVNKSVR 286
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
22-297 1.24e-05

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 46.28  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVTISL-GFCTDFHSCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd15181   15 VVGNGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPFSVVESIaGWVFGTFLCKLVGAIHKLNFYCSSLLLACIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 101 VDRYLAVrvpLRYKSLVTGARARGV---IAALWVLAFGIGLTpflgwndrKIATNCTEPGDAATNVSCCLIRCLFENVVP 177
Cdd:cd15181   94 VDRYLAI---VHAIHSYRHRRLRSVhltCGSIWLVCFLLSLP--------NLVFLEVETSTNANRTSCSFHQYGIHESNW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELmdhsrtvlQREIHAAkslALIVGIFALCWLPVHTIncasL 257
Cdd:cd15181  163 WLTSRFLYHVVGFFLPLLIMGYCYATIVVTLCQSSRRLQK--------QKAIRVA---ILVTLVFCLCWLPYNIV----I 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121957962 258 FQPTWAKVKP-------KWAINTAIL----LSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15181  228 FLDTLDDLKAvvkncklNDLLDAAITvtesLGFSHCCLNPILYAFIGVKFR 278
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
22-138 1.27e-05

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 46.05  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISLgfctdfHSCLFLACFVLVLTQSSI 93
Cdd:cd15229   15 LLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLenllserkTISV------EGCIAQIFFFFFFAGTEA 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGL 138
Cdd:cd15229   89 FLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYAL 133
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
22-134 1.42e-05

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 45.82  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15914   15 ITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPkmLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAM 94
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15914   95 AYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGF 129
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
22-297 1.52e-05

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 46.02  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15183   15 VVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDL-VFLFTLPFWIDYKLKDDWIFGDamCKFLSGFYYLGLYSEIFFIILL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAV---RVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFlgwndrKIATNCTEPGDAATNVSCCLIRCLFENVV 176
Cdd:cd15183   94 TIDRYLAIvhaVFALRARTVTFGIITSIITWALAILASMPCLYFF------KSQWEFTHHTCSAHFPRKSLIRWKRFQAL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMsymvyfNFFGCVLpPLLIMLVIYVKIFLVACRQLQrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLPVHTINCAS 256
Cdd:cd15183  168 KL------NLLGLIL-PLLVMIICYTGIINILLRRPN------------EKKAKAVRLIFVITLLFFLLWTPYNLAAFVS 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962 257 LFQ-----PTWAKVKP-KWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15183  229 AFQdvlftPSCEQSQQlDLALQVTEVIAYTHCCVNPVIYVFVGERFR 275
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
40-135 1.53e-05

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 45.79  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  40 TPTNYFLVSLAAADVAVgLFAIPFAV-------TISLGFCTdfhsclFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLR 112
Cdd:cd15165   33 TESTIYMINLALNDLLL-LLSLPFKMhsskkqwPLGRTLCS------FLESLYFVNMYGSILIIVCISVDRYIAIRHPFL 105
                         90       100
                 ....*....|....*....|...
gi 121957962 113 YKSLVTGARARGVIAALWVLAFG 135
Cdd:cd15165  106 AKRLRSPRKAAIVCLTIWVFVWA 128
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
21-145 1.56e-05

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 45.88  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISlgfctdFHSCLFLACFVLVLTQSS 92
Cdd:cd15424   14 TILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLahllagngAIS------FARCTTQMYIALSLGSTE 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIG--------LTPFLGWN 145
Cdd:cd15424   88 CLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSvinvgctlRHPFCGPN 148
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
38-297 1.59e-05

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 45.96  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  38 LQTPTNYFLVSLAAADVAVGLFAIpFAVTISLG---FCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPL--- 111
Cdd:cd15076   31 LRQPLNYILVNISLAGFIFCIFSV-FPVFVASAqgyFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFERYIVICKPFgnf 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 112 RYKSlvtgARARGVIAALWVLAFGIGLTPFLGWNdRKIAtnctepgdAATNVSCCLIRCLFENVVPMSYMVYFNFFGCVL 191
Cdd:cd15076  110 RFGS----KHALGAVVATWIIGIGVSLPPFFGWS-RYIP--------EGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFI 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 192 PPLLIMLVIYVKIfLVACRQLQRTELMDHSRTVLQREIhaAKSLALIVGIFALCWLPVHTIncASLFQPTWAKVKPKWAI 271
Cdd:cd15076  177 VPLSIIIFSYSQL-LGALRAVAAQQQESASTQKAEREV--SRMVVVMVGSFCLCYVPYAAL--AMYMVNNRDHGLDLRLV 251
                        250       260
                 ....*....|....*....|....*.
gi 121957962 272 NTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15076  252 TIPAFFSKSSCVYNPIIYCFMNKQFR 277
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
38-297 1.63e-05

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 46.16  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  38 LQTPTNYFLVSLAAADVavgLFAIPFAVTISlgfcTDFHSCLF--LACFVLVLTQ-----SSIFSLLAVAVDRYLAVRVP 110
Cdd:PHA02638 128 IKTITDIYIFNLAISDL---IFVIDFPFIIY----NEFDQWIFgdFMCKVISASYyigffSNMFLITLMSIDRYFAILYP 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 111 LRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIR-CLFENVVPMSYMVYF--NFF 187
Cdd:PHA02638 201 ISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEASNIIFSAQDSNETISNYQCTLIEdNEKNNISFLGRILQFeiNIL 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 188 GcVLPPLLIMLVIYVKIFLvACRQLQRTELMDHSRTVlqreihaakslALIVGIFALCWLPvhtINCASLFQPTWAK--- 264
Cdd:PHA02638 281 G-MFIPIIIFAFCYIKIIL-KLKQLKKSKKTKSIIIV-----------SIIIICSLICWIP---LNIVILFATMYSFkgf 344
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 121957962 265 -----------VKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:PHA02638 345 nsiisehicgfIKLGYAMMLAEAISLTHCCINPLIYTLIGENFR 388
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
21-139 1.63e-05

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 45.52  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISlgfctdFHSCLFLACFVLVLTQSS 92
Cdd:cd15225   14 TLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLvnllsedkTIS------FLGCATQMFFFLFLGGTE 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLT 139
Cdd:cd15225   88 CFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLG 134
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
38-300 1.72e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 45.94  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  38 LQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCT---DFHSCLFLACFVlVLTQSSIFSLLAVAVDRYLAVRVPLR 112
Cdd:cd15135   34 LQKSVTDHMVSLACSDLLVLLLGMPveLYSAIWDPFATpsgNIACKIYNFLFE-ACSYATILNVATLSFERYIAICHPFK 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 113 YKSLvTGARARGVIAALWVLAFGIGLtPFL-----------GWNDRKIATNCTEPgdaATNVSCCLI----RCLFENVVP 177
Cdd:cd15135  113 YKAL-SGSRVRLLICFVWLTSALVAL-PLLfamgtedpleaFPSYRGTRHHCQDQ---KSNLTICTSlsskWTVFQASIF 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNFFGCVLPPLLIM---LVIYVKIFLVACRQLQRTELM---DHSRTVLQREiHAAKSLALIVGIFALCWLPVHT 251
Cdd:cd15135  188 SAFVLYLLVLASVAFMCRRMmraLMGSKKGAVAVKGPGGSVQLLrkhESAEGKTARK-QTILFLGLIVGTLAVCWMPNQI 266
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957962 252 INCAslfqpTWAKVKPKWAIN----TAILLSHAN------SAVNPIVYAYRNRDFRYTF 300
Cdd:cd15135  267 RRIM-----AAAKPKDDWTRSyfraYIILLPIADtffylsSVLNPLLYNLSSQQFRSVF 320
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
21-118 1.88e-05

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 45.53  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTD--FHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15955   14 AVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREisFNACLAQMFFIHTLQAFESGILLA 93
                         90       100
                 ....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVT 118
Cdd:cd15955   94 MALDRYVAICHPLRHSSILT 113
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
72-300 2.14e-05

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 45.54  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  72 CTDFHSCLFLACFvlvltqSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGlTPFLG----WNDR 147
Cdd:cd15120   72 CKVLNSTLSVGMF------TSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLS-IPYLAfretRLDE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 148 KIATNCTEPGDAATNVSCCLIRCLFENVVPMSYMVYFnFFGCVLpPLLIMLVIYVKiflVACRQLQRTelmdhsrtvLQR 227
Cdd:cd15120  145 KGKTICQNNYALSTNWESAEVQASRQWIHVAMFVFRF-LLGFLL-PFLIITFCYVR---MALKMKERG---------LAR 210
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121957962 228 EIHAAKSLALIVGIFALCWLPVHtINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15120  211 SSKPFKVMFTAVVSFFVCWLPYH-LHSGLVLTRGRPPSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
24-297 2.17e-05

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 45.56  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPF-AVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd15380   17 GNLFVLFVFLLPRRRLTIAEIYLANLAASDL-VFVLGLPFwAENIRNQFNWPFGNflCRVISGVIKANLFISIFLVVAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 101 VDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATnctepgdaaTNVSCCLIRCLFEnVVPMSY 180
Cdd:cd15380   96 QDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPD---------LNISACILLFPHE-AWHFAR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 181 MVYFNFFGCVLPPLLIMLVIYVKIflvacRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLF-- 258
Cdd:cd15380  166 RVELNIVGFLLPLAAIVFFNFHII-----ASLRERTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDFLfq 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 259 ----QPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15380  241 veviQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
91-300 2.42e-05

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 45.18  E-value: 2.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPF--------LGWNDRkIATNC-TEPGDAAT 161
Cdd:cd15122   87 ASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFvyrhvwkdEGMNDR-ICEPChASRGHAIF 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 162 NVScclirclFENVVPMsymvyfnffgcvLPPLLIMLVIYVKIFlvacRQLQRTELMDHSRTvlqreihaAKSLALIVGI 241
Cdd:cd15122  166 HYT-------FETLVAF------------VLPFGVILFSYSVIL----VRLKGARFRRRARV--------EKLIAAIVVA 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 242 FALCWLPVHTINCASLF-----QPTWAKVKPKWAINTA--ILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15122  215 FALLWVPYHVVNLLQVVanlapGEVLEKLGGAAKAARAgaTALAFFSSSVNPLLYVFAAGDLIKTS 280
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
91-297 2.55e-05

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 45.09  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGI-GLTPFLGWNDRKIATNCTEPGDAATnvscclir 169
Cdd:cd15157   86 CSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAAsSPLLSKGTSKYNSQTKCLDLHPSKI-------- 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 clfENVVPMSYMVYfnFFGCVLpPLLIMLVIYVKIFlvacRQLQRTELMDHSRTVLQREihAAKSLALIVGIFALCWLPV 249
Cdd:cd15157  158 ---DKLLILNYIVL--VVGFIL-PFCTLSICYILII----KALLKPRVPQSKLRVSHKK--ALLTIIITLILFLLCFLPY 225
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 250 HTINCASLFQPTWAKVKPKW--AINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15157  226 HILRTVHLMQWSEGQCNLRLhkAVVITLCLAAANSCLDPLLYYFAGENFK 275
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
38-297 2.79e-05

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 45.20  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  38 LQTPTNYFLVSLAAADVAVGLFAipfAVTISLGFCTDFHSCLFLACFVLVLTQS-----SIFSLLAVAVDRYLAVRVPLR 112
Cdd:cd15077   31 LRSHLNYILVNLAVANLIVVCFG---STTAFYSFSQMYFVLGPLACKIEGFTATlggmvSLWSLAVVAFERFLVICKPLG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 113 YKSLVTGARARGVIAAlWVLAFGIGLTPFLGWNdRKI--ATNCTEPGDAATNvscclirclfENVVPMSYMVYFNFFGCV 190
Cdd:cd15077  108 NFTFRGTHAIIGCIAT-WVFGLAASLPPLFGWS-RYIpeGLQCSCGPDWYTT----------NNKWNNESYVMFLFCFCF 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 191 LPPLLIMLVIYVKIfLVACRQLQRTELMDHSRTVLQREIhaAKSLALIVGIFALCWLPVHTI------NCASLFQPTWAK 264
Cdd:cd15077  176 GVPLSIIVFSYGRL-LLTLRAVAKQQEQSASTQKAEREV--TKMVVVMVLGFLVCWLPYASFalwvvtNRGEPFDLRLAS 252
                        250       260       270
                 ....*....|....*....|....*....|...
gi 121957962 265 VKPkwaintaiLLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15077  253 IPS--------VFSKASTVYNPVIYVFMNKQFR 277
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
22-297 3.21e-05

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 44.81  E-value: 3.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCL-----FLACFVLVLtqsSIFSL 96
Cdd:cd15395   15 VSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMcklnsMVQCISITV---SIFSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSlvTGARARGVIAALWVLAFGIGLtPFLGWN--DRKIATNCTEPGDAATNVSCCLIRCLFEN 174
Cdd:cd15395   92 VLIAIERHQLIINPRGWRP--NNRHAYVGIAVIWVLAVLTSL-PFLIFQvlTDEPFKNVNVSLDAYKGKYVCLDQFPSDT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 175 VvPMSY---MVYFNFFGcvlpPLLIMLVIYVKIFLvacRQLQRTELMDHSRTVLQREIHAAK---SLALIVGIFALCWLP 248
Cdd:cd15395  169 I-RLSYttcLLVLQYFG----PLCFIFICYLKIYI---RLKRRNNMMDKMRDNKYRSSETKRiniMLISIVVAFAVCWLP 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 249 VHTINcaSLFQptWA-KVKPKWAINTAILLSH----ANSAVNPIVYAYRNRDFR 297
Cdd:cd15395  241 LNIFN--AVFD--WNhEAIATCNHNLLFLICHltamISTCVNPIFYGFLNKNFQ 290
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
92-297 3.95e-05

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 44.74  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFgIGLTPFLGWNDRKIATN---CTEPGDAatnvSCCLI 168
Cdd:cd15158   87 SIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVT-LTSSPFLMSGSHDTETNktkCFEPPQS----NQQLT 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 169 RCLFENVVPMsymvyfnFFGCVLpPLLIMLVIYVKIFlvacrqlqRTELMDHSRTVLQREIHaAKSLALIVGI---FALC 245
Cdd:cd15158  162 KLLVLNYISL-------VVGFII-PFLVILICYAMII--------RTLLKNTMKARKQQSSR-KKAIRMIIIVllaFLVS 224
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 246 WLPVH---TINCASLFQ---PTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15158  225 FMPYHiqrTIHLHFLSRkdsTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFR 282
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
21-118 4.14e-05

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 44.43  E-value: 4.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFC--TDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15954   14 AMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLkeISFNACLVQMFFVHTFTGMESGVLML 93
                         90       100
                 ....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVT 118
Cdd:cd15954   94 MALDRYVAICYPLRYATILT 113
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
24-300 4.27e-05

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 44.51  E-value: 4.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFH--SCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15124   17 GNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGrvGCKLIPFIQLTSVGVSVFTLTALSA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLtPFLGWNDRKiatNCTEPGDAATNVSCCLIRCLFENVVPMSYM 181
Cdd:cd15124   97 DRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAI-PEAVFSDLH---PFYDKSTNKTFVSCAPYPHSNELHPKIHSM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 182 VYFNFFGCVlpPLLIMLVIYVKIF--LVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQ 259
Cdd:cd15124  173 ASFLIFYVI--PLSIISVYYYFIAknLIRSAYNLPVEGNVHVRRQIESRKRLAKTVLVFVGLFAFCWLPNHIIYLYRSYH 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 260 PTWAKVKPKWAINT--AILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15124  251 YSEVDTSMLHFVSSicARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
38-297 4.32e-05

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 44.27  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  38 LQTPTNYFLVSLAAADVAVGLFAiPFAVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKS 115
Cdd:cd15072   31 LRTPSNLLVLSLAVADMGISLNA-LVAASSSLLRRWPYGSegCQAHGFQGFFTALASICSSAAIAWDRYHHYCTRSKLQW 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 116 lvtgARARGVIAALWVLAFGIGLTPFLGWND---RKIATNCT---EPGDaatnvscclirclfENVVpmSYMVYFNFFgC 189
Cdd:cd15072  110 ----STAISLVLFVWLFSAFWAAMPLLGWGEydyEPLGTCCTldySKGD--------------RNYV--SYLFTMAFF-N 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 190 VLPPLLIMLVIYVKIflvacrqlqrtelmdHSRtvLQREIHAAKSLALIVGIFALCWLPVHTIncASLFQPTWAKVKPKW 269
Cdd:cd15072  169 FILPLFILLTSYSSI---------------EQK--LKKEGHLRFNTGLPLLTLLICWGPYAIL--ALYAAITDVTSISPK 229
                        250       260
                 ....*....|....*....|....*...
gi 121957962 270 AINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15072  230 LRMVPALLAKTSPTINAILYALGNENYR 257
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
21-134 4.58e-05

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 44.31  E-value: 4.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP-----FAV---TISlgfctdFHSCLFLACFVLVLTQSS 92
Cdd:cd15429   14 TLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPqmlahFLAehkTIS------FASCVAQLFISLALGGTE 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15429   88 FILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGF 129
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
78-297 4.99e-05

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 44.43  E-value: 4.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  78 CLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFlgwndrkIATNCTEPG 157
Cdd:cd14989   71 CTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPF-------TAVQAQHTG 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 158 DaatnVSCClirclFENVVPMSYM-VYFNFfgcvLPPLLIMLVIYVKIFlvacRQLQRTElmDHSRTVLQREiHAAKSLA 236
Cdd:cd14989  144 E----VHFC-----FADVREIQWLeVTLGF----IIPFSIIGLCYSLIV----RVLVRAQ--KHRRLRPRRQ-KALRMIL 203
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121957962 237 LIVGIFALCWLPVHTINCASLFQptwAKVKPKWAINTAI------------LLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd14989  204 VVVLVFFICWLPENVFISIQLLQ---GTQEPSESYDESFrhnhpltghivnLAAFSNSCLNPLIYSFLGETFR 273
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
22-136 5.00e-05

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 44.20  E-value: 5.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPfavTISLGFCTDFHSCLFLAC-----FVLVLTQSSIFSL 96
Cdd:cd15224   15 LLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVP---KLLAGFLSQNKSISFVGCmtqlyFFLSLACTECVLL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGI 136
Cdd:cd15224   92 AVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLI 131
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
22-300 5.16e-05

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 44.43  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--TISLGFCTDFHSCLFLACFVLVLTQSS-----IF 94
Cdd:cd15128   15 IIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVykLLAMDWPFGDQPFGQFLCKLVPFIQKAsvgitVL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  95 SLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATnctepgdAATNVSCCLIRClfEN 174
Cdd:cd15128   95 NLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNY-------KGVTLRTCLLRP--ET 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 175 VVPMSYMVY-----FNFFGCVlpPLLIMLVIYVkifLVACRQLQ------RTELMDHsrtvLQREIHAAKSLALIVGIFA 243
Cdd:cd15128  166 SFMKFYIDVkdwwlFGFYFCL--PLVCTAIFYT---LMTCEMLRkrngmlRIALNEH----LKQRREVAKTVFCLVVIFA 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 244 LCWLPVH--TINCASLFQPT---------WAKVKPKWAINTAILlshaNSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15128  237 LCWLPLHlsRILKLTVYDQNdpnrcellsFLLVLDYFGINLATL----NSCINPIALYFVSRKFKNCF 300
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
45-297 6.09e-05

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 43.99  E-value: 6.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  45 FLVSLAAADVAVgLFAIPF-AVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGAR 121
Cdd:cd15381   38 YLGNLAAADLLL-VCCLPFwAINISNGFNWPFGEflCKSVNAVIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPAC 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 122 ARGVIAALWVLAFGIGlTPFLGWNDRKIATNctepgdaaTNVSCCLIRCLFENVVPMSYMVyFNFFGCVLPPLLIMLVIY 201
Cdd:cd15381  117 AKLNCLIIWMFGLLMS-TPMIVFRTVMYFPE--------YNITACVLDYPSEGWHVALNIL-LNVVGFLIPLSIITFCST 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 202 VKIFLVACRQLQRTELmdhsrtvLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKW------AINTAI 275
Cdd:cd15381  187 QIIQVLRNNKMQKFKE-------IQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLISGCRWedildiGTQIAT 259
                        250       260
                 ....*....|....*....|..
gi 121957962 276 LLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15381  260 FLAYSNSCLNPLLYVIVGKHFR 281
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
21-300 6.32e-05

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 43.74  E-value: 6.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVL--VLTQSSIFslLA 98
Cdd:pfam10320   4 GLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECFWMISFYIfgQTAQGPLM--LM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   99 VAVDRYLAVRVPLRYKSLVTGARArgVIAALWVLAFGIGLT--PFLGWNDRKIATnCTEPGDAATNVScclirclfenvv 176
Cdd:pfam10320  82 IGIDRLIAVKFPIFYRLLSSSKYL--FIQLIFPVIYSSFITvyGFLQRDDETIIV-CAPPLALPGTAF------------ 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  177 pmsymVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTElmdhSRTVLqreihaaKSLALIVGIFALCWLPVHTINCAS 256
Cdd:pfam10320 147 -----TIFTLSSLFINVIVLIVYIILIIIFKNKKQSQNSD----SKKVF-------KSLQVTVVIFIFGWFTSTIANTVF 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 121957962  257 LFQPTWAKVKPKWAINTAILLShANSAVNPIVYAYRNRDFRYTF 300
Cdd:pfam10320 211 LYLTEDGEVEVIIQMYAGFFVL-LSFSQNFFVTYWRSSEYRKAF 253
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
91-252 7.01e-05

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 43.92  E-value: 7.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGlTPFLGWNDRKIAT-NCTEpgdaatnvscclir 169
Cdd:cd15376   87 GSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALS-APVLSFSHLEVERhNKTE-------------- 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 CLFENVVPM--SYMVYFNF---FGCVLpPLLIMLVIYVKIFLVACRqlqrtelmDHSRTVLQREiHAAKSLALIVGIFAL 244
Cdd:cd15376  152 CLGTAVDSRlpTYLPYSLFlavVGCGL-PFLLTLASYLAIVWAVLR--------SPGITTLEKR-KVAALVAVVVALYAV 221

                 ....*...
gi 121957962 245 CWLPVHTI 252
Cdd:cd15376  222 SFVPYHIL 229
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
22-293 8.26e-05

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 43.64  E-value: 8.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLgfCTDFHSCLFLACFVLVLTQ-----SSIFSL 96
Cdd:cd15198   15 VAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWEL--LGDRWMAGDVACRLLKLLQasargASANLV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  97 LAVAVDRYLAVRVPLRYKslvtgARARGVIAALWVLAFGIGLTPFLGWNDRKIatncTEPGDAATNVSCCliRCLFENVV 176
Cdd:cd15198   93 VLLALDRHQAIRAPLGQP-----LRAWKLAALGWLLALLLALPQAYVFRVDFP----DDPASAWPGHTLC--RGIFAPLP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 177 PMSYMVYFNFFGCV--LPPLLIMLVIYVKIFLV------------ACRQLQR-TELMDHSRTVLQR-EIHAAKSLALIVG 240
Cdd:cd15198  162 RWHLQVYATYEAVVgfVAPVVILGVCYGRLLLKwweranqapgakKPWKKPSkSHLRATAPSALPRaKVKTLKMTLVIAL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 241 IFALCWLPVHTINCASLFQP-TWAKVKPKWAINtaiLLSHANSAVNPIVYAYRN 293
Cdd:cd15198  242 LFVGCSLPYFIAELAAAFGSgDWEPEKVAAALG---VMAVANSATNPFVFLFFN 292
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
21-297 8.88e-05

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 43.50  E-value: 8.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVaVGLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15182   14 SLLGNGLVLWILVKYEKLKTLTNIFILNLAISDL-LFTFTLPFwASYHSSGWIFGEILCKAVTSIFYIGFYSSILFLTLM 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKiatnctepgdAATNVSCCLIRCLFENVVpmS 179
Cdd:cd15182   93 TIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMK----------SDEDGSLCEYSSIKWKLG--Y 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFgcvLPPLLIMLVIYVKIFlvacRQLQRTELMDHSRTVlqreihaaKSLALIVGIFALCWLPVH-TINCASLF 258
Cdd:cd15182  161 YYQQNLFF---LIPLGIIVYCYVRIL----QTLMRTRTMRKHRTV--------KLIFVIVLVFFLSWAPYNiVIFLRSLK 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 121957962 259 QPTWAKVKPKWAINTAILLS----HANSAVNPIVYAYRNRDFR 297
Cdd:cd15182  226 DLTIPICECSKQLDYAFYICrniaFSHCCLNPVFYVFVGVKFR 268
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
24-120 9.79e-05

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 43.35  E-value: 9.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIslgFCTDFHSCLFLACFV--LVLTQSSIFS---LLA 98
Cdd:cd15948   18 GNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSI---FWFNSREINFNACLVqmFFLHSFSIMEsavLLA 94
                         90       100
                 ....*....|....*....|..
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGA 120
Cdd:cd15948   95 MAFDRYVAICNPLRYATILTNS 116
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
38-300 1.07e-04

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 43.37  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  38 LQTPTNYFLVSLAAADVaVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQ--SSIFSLLAVAVDRYLAVRVPLRYKS 115
Cdd:cd15155   31 MRNETAIFMTNLAVSDL-LFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNiyGSMLFLTCISVDRFLAIVYPFRSRT 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 116 LVTGARARGVIAALW--VLAFGIGLTPFLGWNDRKIATNCTEPgdaatnvscclirclFENVVPMSYMVYFNFFGCVLpP 193
Cdd:cd15155  110 IRTRRNSAIVCAGVWilVLSGGISASLFSTTNVSNTSTTCFEG---------------FSKSIWKTYLSKITIFIEVV-G 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 194 LLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIhaaKSLALIVGIFALCWLPVHTIncasLFqpTWAKVKPKWAINT 273
Cdd:cd15155  174 FIIPLLLNLTCSSLVLRTLRKPATLSQIGTNKEKVL---KMILVHVAIFVVCFVPYNSI----LF--LYALVRSQAIANC 244
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 121957962 274 AI------------LLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15155  245 GVerfartmypitlCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
21-134 1.11e-04

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 43.21  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL---GFCTDFHSCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15916   14 TVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLepgGKVISFGGCVAQLYFFHFLGSTECFLYT 93
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15916   94 LMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGS 130
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
21-140 1.14e-04

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 43.07  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15913   14 TLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPnmLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSV 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTP 140
Cdd:cd15913   94 MAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIP 135
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
78-297 1.32e-04

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 42.85  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  78 CLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPlrYKSLVTGARARGVI-AALWVLAFGIGLTPFlgWNDRKIATNCTEP 156
Cdd:cd15966   80 CRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVFP--FSNIRPGKCQTLIIlISIWLVGFIIAVIPF--WNEDFFGNYYGKN 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 157 GdaatnVSCCLIRCLFENVVPMSYMVYFnFFGCVLPPLLIMLVIYVKIFL-VACRQLQRTELMDHsrtvLQREIHAAKSL 235
Cdd:cd15966  156 G-----VCFPLHSDQTEKIGAKGYSTGI-FLGLNLLAFIIIVFSYSSMFCsIQKTGLQTTEVRSH----IHRDVAVANRF 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121957962 236 ALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAIntaILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15966  226 FFIVFSDAICWIPIFLLKILSLFQVEIPGTITSWIV---IFILPINSALNPILYTLTTSFFK 284
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
40-289 1.55e-04

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 42.84  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  40 TPTNYFLVSLAAADVAVGlFAIPFAVTISLG----FCTDFHSCLFLACFVLVLtQSSIFSLLAVAVDRYLAVRVPLRYKS 115
Cdd:cd15968   33 TRTAIYMVNLALADLLYA-LSLPLLIYNYAMrdrwLFGDFMCRLVRFLFYFNL-YGSILFLTCISVHRYLGICHPMRPWH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 116 LVTGARARGVIAALWVLAFGIgLTPFLGWNDRKIATNCTEPGDAAtnvscclIRCLFENVVPMSYMVYFNFFGCvlpPLL 195
Cdd:cd15968  111 KETRRAAWLTCVLVWILVFAQ-TLPILIFARTGIIRNRTVCYDLA-------PPALFPHYVPYGMALTVSGFLL---PFS 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 196 IMLVIYVKIFLVACRQLQRTELmdhsrTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFqptwakVKPKWAINTAI 275
Cdd:cd15968  180 IILWCYCLVVRTLCRTLGPAEP-----PAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLA------VRVTPGVPCHV 248
                        250       260
                 ....*....|....*....|....*.
gi 121957962 276 L------------LSHANSAVNPIVY 289
Cdd:cd15968  249 LeavaacykitrpLASANSVLNPLLY 274
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
21-115 1.62e-04

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 42.77  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIslgFCTDFHSCLFLACFV-------LVLTQssI 93
Cdd:cd15412   14 TLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVN---FLSEKKTISFAGCFTqcyffiaLVITE--Y 88
                         90       100
                 ....*....|....*....|..
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKS 115
Cdd:cd15412   89 YMLAVMAYDRYMAICNPLLYSV 110
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-249 1.64e-04

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 42.88  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  26 VLVCAAVGTSSALQTPTNYFLVSLAAAD----VAVGLFAIPFAVTIS--LGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 99
Cdd:cd15143   24 VLVKSSRKTKSRSRSSFLIFLCGLVVTDflglLVTGTIVISFHLTNFnwRVVDPDCYLCNFMGLSMVFYGLCPLLLGATM 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 100 AVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATnctePGdaatnvSCCLIRCLFENvVPMS 179
Cdd:cd15143  104 AVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGLLPILGLGRYTLQY----PG------SWCFLTLLFDS-KDVA 172
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121957962 180 YMVYFNFFGCVLPPLLIML--VIYVKIFLVACRQLQRTELMDHsrtvlqrEIHAAKSLALIVGIFALCWLPV 249
Cdd:cd15143  173 FGLLFSFLGILSVGLSFLLntVSVVTLCRVYHDRESVQRRRDS-------EVEMMVQLLGIMVIASVCWLPL 237
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-297 1.89e-04

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 42.45  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  45 FLVSLAAADVaVGLFAIPF-AVTISLGFCTDFHS--CLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGAR 121
Cdd:cd15189   38 YLGNLAAADL-VFVSGLPFwAMNILNQFNWPFGEllCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRY 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 122 ARGVIAALWVLAFGIGLTPFLGWNDRKIatnctepgdAATNVSCCLIRCLFENvVPMSYMVYFNFFGCVLPPLLIMLVIY 201
Cdd:cd15189  117 AKLICVLIWVVGLLLSIPTFLLRKIKAI---------PDLNITACVLLYPHEA-WHFAHIVLLNIVGFLLPLLVITFCNY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 202 VKIFLVACRQLQrtelmdhSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKW------AINTAI 275
Cdd:cd15189  187 NILQALRTREES-------TRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGVLDECFWehfidiGLQLAV 259
                        250       260
                 ....*....|....*....|..
gi 121957962 276 LLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15189  260 FLAFSNSCLNPVLYVFVGRYFR 281
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
21-297 2.04e-04

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 42.20  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAAD----VAVGLFAIPFAVTIS-----------------LGFCTDFHSCL 79
Cdd:cd15136   14 ALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADfcmgIYLGLLAIVDAKTLGeyynyaidwqtgagcktAGFLAVFSSEL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  80 flacfvlvltqsSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRkiatnctepgda 159
Cdd:cd15136   94 ------------SVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSY------------ 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 160 aTNVSCCLIrclFENVVPMS--YMVYFNFFGCVlpPLLIMLVIYVKIFLvacrQLQRTELMDHSrtvlqREIHAAKSLAL 237
Cdd:cd15136  150 -SKTSICLP---FETETPVSkaYVIFLLLFNGL--AFLIICGCYIKIYL----SVRGSGRAANS-----NDTRIAKRMAL 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121957962 238 IVGIFALCWLPVhtincaSLFQPTWAKVKPKWAINTA-ILLSHA---NSAVNPIVYAYRNRDFR 297
Cdd:cd15136  215 LVFTDFLCWAPI------AFFGLTAAFGLPLISVSNAkILLVFFyplNSCANPFLYAIFTKQFR 272
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
21-129 2.12e-04

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 42.35  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPfavTISLGFCTDFHSCLFLAC-----FVLVLTQSSIFS 95
Cdd:cd15406   23 TVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITP---KMLVNFVSEKNIISYPECmtqlfFFCVFAIAECYM 99
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 121957962  96 LLAVAVDRYLAVRVPLRYK---------SLVTGARARGVIAAL 129
Cdd:cd15406  100 LTAMAYDRYVAICNPLLYNvtmsprvcsLLVAGVYIMGLIGAT 142
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
22-297 2.24e-04

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 42.39  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLvSLAAADVAVGLfAIPF-AVTISLGFCTDF--HSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15114   15 VPGNALVAWVTGFEAKRSVNAVWFL-NLAVADLLCCL-SLPIlAVPIAQDGHWPFgaAACKLLPSLILLNMYASVLLLTA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwnDRKIATNCTEP---------GDAATNVSCCLIR 169
Cdd:cd15114   93 ISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFI---YRRIHQEHFPEktvcvvdygGSTGVEWAVAIIR 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 170 clfenvvpmsymvyfnFFGCVLPPLLIMLVIYVKIfLVACRQLQRTELMDHSRTVLqreihaakslALIVGIFaLCWLPV 249
Cdd:cd15114  170 ----------------FLLGFLGPLVVIASCHGVL-LVRTWSRRRQKSRRTLKVVT----------AVVVGFF-LCWTPY 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 250 HTINC--ASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15114  222 HVVGLiiAASAPNSRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFR 271
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
24-297 2.50e-04

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 42.13  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVavgLFAI--PFAVTISLGFCTDFHS-CLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd15186   17 GNLLVVLALTNSGKSKSITDIYLLNLALSDL---LFVAtlPFWTHYLINEWGLHNAmCKLTTAFFFIGFFGGIFFITVIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 101 VDRYLAVrvPLRYKSLVTGARARGVIAALWVLAFGIGL-TPFLGWNDRKiATNCTepGDAATnvscclircLFENVVPMS 179
Cdd:cd15186   94 IDRYLAI--VLAANSMNNRTVQHGVTISLGVWAAAILVaVPQFMFTKMK-ENECL--GDYPE---------VLQEIWPVL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 180 YMVYFNFFGCVLPpLLIMLVIYVKIF--LVACRQlqrtelmdhsrtvlQREIHAAKSLALIVGIFALCWLP------VHT 251
Cdd:cd15186  160 RNVELNFLGFLLP-LLIMSYCYFRIIqtLFSCKN--------------HKKARAIKLILLVVIVFFLFWTPynvmifLET 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962 252 INCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15186  225 LKLYDFFPSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFR 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
22-134 2.92e-04

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 41.70  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADvavglfaIPFAVTIS----LGFCTDFHSCLFLACFvlvlTQSSIFSLL 97
Cdd:cd15911   15 MAGNILIIVLVVADRHLHTPMYFFLGNLSCLE-------ICYTSTILprmlASLLTGDRTISVSGCI----VQFYFFGSL 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 121957962  98 AVA---------VDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15911   84 AATecyllavmsYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGF 129
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
22-134 3.12e-04

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 41.87  E-value: 3.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISlgfctdFHSCLFLACFVLVLTQSSI 93
Cdd:cd15231   15 LLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLvnllrerkTIS------YIGCLAQLFFFVSFVGTEC 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 121957962  94 FSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15231   89 LLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGF 129
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
21-297 3.14e-04

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 41.68  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFaIPFAVTISL-GFCTDFHSCLFLACFVLVLTQ--SSIFSLL 97
Cdd:cd15368   14 SIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACF-LPFQIVYHIqRNHWIFGKPLCNVVTVLFYANmySSILTMT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIgLTPFLgwndrkiATNCTEPGDAATNVSC--CLIRCLFENV 175
Cdd:cd15368   93 CISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTA-LSPLE-------RTDLTYYVKELNITTCfdVLKWTMLPNI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRtelmdHSRTVLQREIHAAkslALIVGIFALCWLPVHTINCA 255
Cdd:cd15368  165 AAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSER-----YGREQKRRAIYLA---LIVLLVFITCFAPNNFILLA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121957962 256 SLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15368  237 HMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFR 278
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
8-293 3.27e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 41.68  E-value: 3.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962   8 AVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISL---GFCTDFHSCLFLACF 84
Cdd:cd15212    1 AAQALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFsrpGWLFGDRLCLANGFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  85 VLVLTQSSIFSLLAVAVDRYLAVRVPLRYKslVTGARARGVIAALWVLAFGIGLTPFLgwndrkiaTNCTEPGDAATNVS 164
Cdd:cd15212   81 NACFGIVSTLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAWLTALGFSLPWYL--------LASAPEYYEKLGFY 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 165 CCLIRcLFENVVPM--SYMVYFnFFGCVLPPLLIMLVIYVKIflvaCRQLQRTELMDHSRTVLQR------EIHAAKSLA 236
Cdd:cd15212  151 HCLYV-LHSGPSRLgaAYSSVL-IVLCYLLPFALMCFCHYNI----CKTVRLSESRVRPVTTYAHllrfysEMRTATTVL 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121957962 237 LIVGIFALCWLP--VHTINCASL---FQPTWAKVkpkwaintAILLSHANSAVNPIVYAYRN 293
Cdd:cd15212  225 IMIVFIICCWGPycLLGLVAAAGgyqFPPLMDTV--------AIWMAWANGAINPLIYAIRN 278
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
22-300 3.33e-04

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 41.65  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADvavGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQ----SSIFSLL 97
Cdd:cd15087   15 LTGNTAVIYVILRAPKMKTVTNVFILNLAIAD---DLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHynifSSIYFLT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  98 AVAVDRYLAVRVPLRYKSLV--TGARARGVIAALWVLAFGIGLtPFlgwndrkiATNCTEPGDAATNVSCCLIRCLFENV 175
Cdd:cd15087   92 VMSVDRYLVVLATVRSRRMPyrTYRAAKIVSLCVWLLVTIIVL-PF--------TVFAGVYSNELGRKSCVLSFPSPESL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 176 VPMSYMVYFNFFGCVLPplliMLVIYVkIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCA 255
Cdd:cd15087  163 WFKASRIYTLVLGFAIP----VSTICI-LYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121957962 256 SL---FQPTWAKVKPKWAINTailLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15087  238 ALttdLPQTPLVIGISYFITS---LSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
31-300 3.56e-04

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 41.67  E-value: 3.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  31 AVGTSSALQTPTNYFLVSLAAADVAVGLfAIPFAVTISLGFC----TDFHsCLFLACFVLVLTQSSIFSLLAVAVDRYLA 106
Cdd:cd15167   24 AFIQKRSSRKCINIYLINLLTADFLLTL-ALPVKIAVDLGIApwklKIFH-CQVTACLIYINMYLSIIFLGFVSIDRYLQ 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 107 VRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLgwndrkIATNCTEPGDAATNVScclirclFENVVPMSYMVYFNF 186
Cdd:cd15167  102 LTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMA------IPIKTIEEKPGVGCAD-------FKTEFGRHWHVLTNF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 187 FgCVLPPLLIMLVIYVKIFLVAcRQLQRTELMDHSRTVLQreihAAKSLALIVGIFALCWLPVHTINCASLFQPTWA--- 263
Cdd:cd15167  169 I-CMAIFLNFSAIILISNFLVI-RKLYRNKDSEEYRNARQ----ALVNILLVTAGYVICFVPYHIVRIPYTLSQSEVitd 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 121957962 264 ---KVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15167  243 cslKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
21-131 3.61e-04

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 41.67  E-value: 3.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLgfcTDFHSCLFLAC-----FVLVLTQSSIFS 95
Cdd:cd15227   14 ALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSL---TNTRSISFLGCvaqvfLFIFFAASELAL 90
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 121957962  96 LLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWV 131
Cdd:cd15227   91 LTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWL 126
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
21-133 3.74e-04

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 41.68  E-value: 3.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLF--------------AIPFAVTISLGFCTDFHSCLflacfvl 86
Cdd:cd15236   14 TVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVtvpkmlmnmqtqdqSIPYAGCISQMYFFIFFGCL------- 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 121957962  87 vltqsSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLA 133
Cdd:cd15236   87 -----DSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLT 128
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
21-134 6.27e-04

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 40.75  E-value: 6.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15915   14 SLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPkmLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAV 93
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 121957962  99 VAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15915   94 MAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGF 129
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
92-250 6.42e-04

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 40.99  E-value: 6.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNdrKIATNCTepgdaATNVSCCLIRCL 171
Cdd:cd15976   87 TVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFD--MITMDYK-----GELLRICLLHPI 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 FENVVPMSYMVY-----FNFFGCVlpPLLIMLVIYVkifLVACRQLQRTELM-----DHSRTvlQREIhaAKSLALIVGI 241
Cdd:cd15976  160 QKTAFMQFYKTAkdwwlFSFYFCL--PLACTAVFYT---LMTCEMLRKKNGMqialnDHLKQ--RREV--AKTVFCLVLV 230

                 ....*....
gi 121957962 242 FALCWLPVH 250
Cdd:cd15976  231 FALCWLPLH 239
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
21-129 7.05e-04

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 40.77  E-value: 7.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPfavTISLGFCTDFHSCLFLAC-----FVLVLTQSSIFS 95
Cdd:cd15408   27 TLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITP---KTLLNLLAERKVISFTGCltqlyFYAVFATTECYL 103
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 121957962  96 LLAVAVDRYLAVRVPLRYK---------SLVTGARARGVIAAL 129
Cdd:cd15408  104 LAAMAYDRYVAICNPLLYTvimsqrvcvSLVAGSYLAGFLNST 146
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
21-134 7.30e-04

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 40.72  E-value: 7.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISlgfctdFHSCLFLACFVLVLTQSS 92
Cdd:cd15237   14 TLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLvhllsehkTIS------FVGCAAQMFFFLALGVTE 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15237   88 CVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGF 129
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
91-135 7.34e-04

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 40.71  E-value: 7.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFG 135
Cdd:cd15170   87 ISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFS 131
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
24-113 8.14e-04

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 40.49  E-value: 8.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISLGFCTdfhSCLFLACFvLVLTQSSIFS 95
Cdd:cd15228   17 GNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLaylwgqsrVISLGGCM---SQVFFYHF-LGSTECLLYT 92
                         90
                 ....*....|....*...
gi 121957962  96 LLavAVDRYLAVRVPLRY 113
Cdd:cd15228   93 VM--AYDRYVAICHPLRY 108
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
92-252 9.20e-04

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 40.55  E-value: 9.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLG---WNDRKIATNCTEPgdaatnvsccli 168
Cdd:cd15366   87 SIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHdelFRDRYNHTFCFEK------------ 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 169 rclfenvVPMSY----MVYFNFFGCVLPPLLIMLVIYVKIfLVACRQLQRTElmdhsrtvlQREIHAAKSLAL-IVGIFA 243
Cdd:cd15366  155 -------YPMEDwvawMNLYRVFVGFLFPWVLMLFSYRGI-LRAVRGNVSTE---------QQEKAKIKRLALsLIAIVL 217

                 ....*....
gi 121957962 244 LCWLPVHTI 252
Cdd:cd15366  218 LCFAPYHVL 226
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
22-134 1.22e-03

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 39.89  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVA----------VGLFAIpfAVTISLGFC-TDFHSCLFLACfvlvltq 90
Cdd:cd15939   15 VLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICyssttapkliVDLLSE--RKTISFNGCmTQLFAEHFFGG------- 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15939   86 AEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGF 129
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
21-118 1.36e-03

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 40.00  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP-----FAV---TISlgfctdFHSCLFLACFVLVLTQSS 92
Cdd:cd15413   14 TVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPkmlvnFVVeqnTIS------FYACATQLAFFLTFIISE 87
                         90       100
                 ....*....|....*....|....*.
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRYKSLVT 118
Cdd:cd15413   88 LFLLSAMAYDRYVAICNPLLYTVIMS 113
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
24-297 1.45e-03

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 39.81  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPFAVTISLGFCTDF--HSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15185   17 GNVVVVVILIKYRRLRIMTNIYLLNLAISDLLF-LFTLPFWIHYVRWNNWVFghGMCKLLSGFYYLGLYSEIFFIILLTI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 102 DRYLAVrvplryKSLVTGARAR----GVIAAL--WVLAFGIGLTPFLGWNDRKI--ATNCTE--PGDAatnvscclircl 171
Cdd:cd15185   96 DRYLAI------VHAVFALRARtvtfGIITSIitWGLAVLAALPEFIFYETQELfeEFLCSPlyPEDT------------ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 fENVVPMSYMVYFNFFGCVLpPLLIMLVIYVKIFlvacrqlqRTELmdhsRTVLQREIHAAKSLALIVGIFALCWLPVHT 251
Cdd:cd15185  158 -EDSWKRFHALRMNIFGLAL-PLLIMVICYTGII--------KTLL----RCPSKKKYKAIRLIFVIMVVFFIFWTPYNL 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121957962 252 INCASLFQPTWAKVKPK------WAINTAILLSHANSAVNPIVYAYRNRDFR 297
Cdd:cd15185  224 VLLLSAFQSIFFETDCErskhldLAMQVTEVIAYTHCCINPVIYAFVGERFR 275
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
21-134 1.53e-03

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 39.61  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTIslgFCTDFHSCLFLACFV-----LVLTQSSIFS 95
Cdd:cd15411   14 TVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALEN---FLSGRKAISFAGCFVqmyffIALATTECFL 90
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 121957962  96 LLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15411   91 LGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGF 129
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
21-113 1.55e-03

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 39.48  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISlgfctdFHSCLFLACFVLVLTQSS 92
Cdd:cd15234   14 TVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLvniqtqskSIS------YTGCLTQMCFFLLFGGLD 87
                         90       100
                 ....*....|....*....|.
gi 121957962  93 IFSLLAVAVDRYLAVRVPLRY 113
Cdd:cd15234   88 NFLLAVMAYDRYVAICHPLHY 108
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
21-140 1.77e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 39.55  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFA-VTISLGFCTDFH--SCLFLACFVLVLTQSSIFSLL 97
Cdd:cd15217   14 SLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVlVSIRNGSAWTYSvlSCKIVAFMAVLFCFHAAFMLF 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 121957962  98 AVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTP 140
Cdd:cd15217   94 CISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPP 136
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
21-134 1.86e-03

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 39.41  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVA----------VGLFAIpfAVTISlgfctdFHSCLFLACFVLVLTQ 90
Cdd:cd15230   14 TLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICyssvitpkmlVNFLSE--KKTIS------FAGCAAQFFFFAVFGT 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15230   86 TECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGF 129
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
21-289 1.87e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 39.40  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAI--PFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15386   14 ATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVlpQLIWEITYRFQGPDLLCRAVKYLQVLSMFASTYMLIM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRykSLVTGAR-ARGVIAALWVLAFGIGLTPFLGWNDRKIatnctEPGDaatnvscCLIRCLFENVVP 177
Cdd:cd15386   94 MTVDRYIAVCHPLR--TLQQPSRqAYLMIGATWLLSCILSLPQVFIFSLREV-----DQGS-------GVLDCWADFGFP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 178 MSYMVYFNF--FGCVLPPLLIMLVIYVKIFLVACRQL-------------QRTELM----DHSRTVLQREIHAAKSLALI 238
Cdd:cd15386  160 WGAKAYITWttLSIFVLPVAILIVCYSLICYEICKNLkgktqtsrsegggWRTQGMpsrvSSVRTISRAKIRTVKMTFVI 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121957962 239 VGIFALCWLPVHTINCASLfqptWAKVKPK-----WAINTAILLSHANSAVNPIVY 289
Cdd:cd15386  240 VLAYIACWAPFFSVQMWSV----WDENAPDedssdFAFTITMLLASLSSCCNPWIY 291
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
24-134 2.42e-03

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 38.95  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCT--DFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15937   17 GNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKtiSYGGCMAQLFFLHFLGAAEMFLLVAMAY 96
                         90       100       110
                 ....*....|....*....|....*....|...
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15937   97 DRYVAICKPLHYTTVVNRRVCCVLVGASWAGGF 129
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
21-118 2.57e-03

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 38.93  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAvglFAIPFAVTISLGFCTDFHSCLFLACFV-----LVLTQSSIFS 95
Cdd:cd15415   14 TLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLC---YSSVFAPRLLVNFLVEKKTISYSACIAqhfffAVFVTTEGFL 90
                         90       100
                 ....*....|....*....|...
gi 121957962  96 LLAVAVDRYLAVRVPLRYKSLVT 118
Cdd:cd15415   91 LAVMAYDRYVAICNPLLYTVAMT 113
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
21-291 2.94e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 39.03  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAI-PfavtislGFCTD----FHSCLFLaCFVLVLTQ----- 90
Cdd:cd15385   14 AVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVlP-------QLCWDityrFYGPDFL-CRIVKHLQvlgmf 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTgARARGVIAALWVLAFGIGLTPFLGWNDRKIatnctEPGDAATNvscclirC 170
Cdd:cd15385   86 ASTYMLVMMTADRYIAICHPLKTLQQPT-KRSYLMIGSAWALSFILSTPQYFIFSLSEI-----ENGSGVYD-------C 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 LFENVVPMSYMVYFNFF--GCVLPPLLIMLVIYVKIFL-----VACRQLQRTE-----------LMDHSRTVLQREIHAA 232
Cdd:cd15385  153 WANFIVPWGIKAYITWItiSIFVVPVIILLTCYGFICYniwrnIKCKTRRGLSdnalknillavCVSSVKTISRAKIRTV 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 233 KSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINT-AILLSHANSAVNPIVYAY 291
Cdd:cd15385  233 KMTFVIVLAYIVCWAPFFTIQMWSVWDQNFPWDESENTAVTiTALLASLNSCCNPWIYMF 292
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
22-138 2.95e-03

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 38.96  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVgLFAIPF-AVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVA 100
Cdd:cd15176   15 LAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFwAADAVNGWVLGTAMCKITSALYTMNFSCGMQFLACIS 93
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 121957962 101 VDRYLAV-RVPLRYKslvTGARARGVIAALWVLAFGIGL 138
Cdd:cd15176   94 VDRYVAItKATSRQF---TGKHCWIVCLCVWLLAILLSI 129
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
39-144 3.22e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 38.73  E-value: 3.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  39 QTPTNYFLVSLAAADVAVgLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAV----DRYLAVRVPLRYK 114
Cdd:cd15919   33 QKSSYNYLLALAAADILV-LFFIVFVDFLLEDFILNKQMPQVLDKIIEVLEFSSIHTSIWITVpltiDRYIAVCHPLKYH 111
                         90       100       110
                 ....*....|....*....|....*....|
gi 121957962 115 SLVTGARARGVIAALWVLAFgIGLTPFLGW 144
Cdd:cd15919  112 TVSYPARTRKVIVSVYITCF-LTSIPYYWW 140
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
21-182 3.66e-03

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 38.61  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15428   14 TVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVhlLSERKIISFIRCAAQLYFFLSFGITECALLSV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYK---------SLVTGARARGVIAALWVLAFGIGLtPFlgWNDRKIATNCTEP--------GDAAT 161
Cdd:cd15428   94 MSYDRYVAICLPLRYSlimtwkvciSLATGSWVGGLLVSAVDTAFTLNL-SF--GGHNKINHFLCEMpallklasTDTHQ 170
                        170       180
                 ....*....|....*....|.
gi 121957962 162 NVSCCLIRCLFENVVPMSYMV 182
Cdd:cd15428  171 AEMAMFIMCVFTLVLPVLLIL 191
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
22-300 3.87e-03

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 38.69  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  22 VTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSC---LFLACFVLVLTQSSI----F 94
Cdd:cd15975   15 MVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFDDSsfgVFLCKLVPFLQKASVgitvL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  95 SLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAF--------GIGLTPFlGWNDRKIATnctepgdaatnvscc 166
Cdd:cd15975   95 NLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFilaipeaiGFVMVPF-EYNGEQYRT--------------- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 167 lirCLFENVVP-MSYMVY------FNFFGCVlpPLLIMLVIYVkifLVACRQLQ------RTELMDHsrtvLQREIHAAK 233
Cdd:cd15975  159 ---CMLNATTKfMNFYVDakdwwlFGFYFCV--PLACTAIFYT---LMTCEMLNrrkgslRIALSEH----LKQRREVAK 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121957962 234 SLALIVGIFALCWLPVH--TINCASLFQP---------TWAKVKPKWAINTAILlshaNSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15975  227 TVFCLVVIFALCWFPLHlsRILKKTVYNEndprrcellSFLLVMDYISINLATM----NSCINPIALYFVSKKFKNCF 300
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
21-300 5.23e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 37.92  E-value: 5.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFA-VTISL-----GFCTDFHS---CLFLACFVLVLTQS 91
Cdd:cd15360   14 AITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIAsVDIRTksqyyNYAIDWQTgagCAAAGFFTVFASEL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  92 SIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTePGDAATNVScclircl 171
Cdd:cd15360   94 SVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICL-PMDIESPLS------- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 172 fenvvpMSYMVYFNFFGCVlpPLLIMLVIYVKIFLVacrqlqrteLMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHT 251
Cdd:cd15360  166 ------QAYIIFILVLNVL--AFLIICACYIKIYLT---------VRNPNFVSSNSDTKIAKRMAVLIFTDFLCMAPISF 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121957962 252 IN-CASLFQPTWAKVKPKWAIntaILLSHANSAVNPIVYAYRNRDFRYTF 300
Cdd:cd15360  229 FAiSASLKVPLITVSKSKILL---VLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
21-118 5.72e-03

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 37.80  E-value: 5.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 98
Cdd:cd15942   14 TLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPkvIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTV 93
                         90       100
                 ....*....|....*....|
gi 121957962  99 VAVDRYLAVRVPLRYKSLVT 118
Cdd:cd15942   94 MAYDRFLAICKPLHYSTIMN 113
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
91-298 5.93e-03

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 37.81  E-value: 5.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGL--TPFLgwndrKIATNctepgdAATNVSCCLI 168
Cdd:cd14987   86 GSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLpdTYFL-----KTVTS------PSNNETYCRS 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 169 RCLFENVvpMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQlqrtelmdhSRTVLQREIHAAKSLALIVGIFALCWLP 248
Cdd:cd14987  155 FYPEESF--KEWLIGMELVSIVLGFVIPFPIIAVFYFLLARAI---------SASSDQERKSSRKIIFSYVVVFLVCWLP 223
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121957962 249 VHT---INCASLFQPTWAKVKPKWAINTAILLSHANS----AVNPIVYAYRNRDFRY 298
Cdd:cd14987  224 YHTvvlLDILSFLHLIPFSCQLENFLYAALHVTQCFSlvhcCVNPILYSFINRNYRY 280
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
45-296 5.99e-03

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 37.83  E-value: 5.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  45 FLVSLAAADvavglfaipFAVTISLGFCTDFHSCLFL------ACFVLVLTQS-----SIFSLLAVAVDRYLAVRVPLRY 113
Cdd:cd15200   38 YLLSLVVAD---------FFLIINLPFRIDYYLRNEVwrfgatACQVNLFMLSmnrtaSIVFLTAIALNRYLKVVHPHHQ 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 114 KSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKiatnctepgdaatNVSCCLIRCLFENVVPMSYMVYFNFFGCVLPP 193
Cdd:cd15200  109 LSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQS-------------NSTCLSYDHGTDPSASDRWHRILFFLEFFLPL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 194 LLIMLVIYVKIFLVACRQLQRtelmdhsRTVLQReihAAKSLALIVGIFALCWLPVHTINCASLFqpTWaKVKPKWAINT 273
Cdd:cd15200  176 GIILFCIFSIILTLKQRKLAK-------QAGPQR---AVKVLAVIVLVYTVCFLPSILFALASLV--AF-KVSQCRSLDL 242
                        250       260       270
                 ....*....|....*....|....*....|
gi 121957962 274 AILLSHA-------NSAVNPIVYAYRNRDF 296
Cdd:cd15200  243 CTQLFHGslaftylNSALDPVLYCFSSPSF 272
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
24-134 6.16e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 37.93  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  24 GNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIP--FAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAV 101
Cdd:cd15938   17 GNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPkmLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAY 96
                         90       100       110
                 ....*....|....*....|....*....|...
gi 121957962 102 DRYLAVRVPLRYKSLVTGARARGVIAALWVLAF 134
Cdd:cd15938   97 DRYVAICKPLHYTTIMSRRLCWVLVAASWAGGF 129
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
91-297 6.57e-03

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 37.77  E-value: 6.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  91 SSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAfGIGLTPFLGWNDRKIATNCTEPGDAATnvscclirc 170
Cdd:cd15378   85 SSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLV-TLELLPILTFIGPNLKDNVTKCKDYAS--------- 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962 171 LFENVVPMSYMVYFNFFGCVLpPLLIMLVIYVKIFLVacrqLQRTELMDHSRTVLQREIhaaKSLALIVGIFALCWLPVH 250
Cdd:cd15378  155 SGDATNSLIYSLFLTVTGFLI-PLCVMCFFYYKIALF----LKNRNRQLANATSFEKPL---TLVILAVVIFSVLFTPYH 226
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121957962 251 TI-NCASLFQPTWAKVKP--KWAINTAILLSHA----NSAVNPIVYAYRNRDFR 297
Cdd:cd15378  227 VMrNVRIASRLDSIGVSEctLIIIKSLYIVTRPiaflNSVINPVFYFLMGDHFR 280
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
21-113 8.33e-03

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 37.42  E-value: 8.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  21 SVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAvglFAIPFAVTISLGFCTDFHSCLFLAC-----FVLVLTQSSIFS 95
Cdd:cd15945   27 TLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLC---YSTAIGPKMLVDLLAKRKSIPFYGCalqmfFFAAFADAECLL 103
                         90
                 ....*....|....*...
gi 121957962  96 LLAVAVDRYLAVRVPLRY 113
Cdd:cd15945  104 LAVMAYDRYVAICNPLLY 121
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
36-141 8.70e-03

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 37.36  E-value: 8.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957962  36 SALQTPTNYFLVSLAAADVAVGLFAIPFAV--------TISlgfctdFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAV 107
Cdd:cd15434   29 SRLHTPMYFFLANLSFLDLCFTTSIIPQMLvnlwgpdkTIS------YVGCAIQLFIALGLGGTECVLLAVMAYDRYAAV 102
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 121957962 108 RVPLRYKSLVTGARARGVIAALWVLAFG--IGLTPF 141
Cdd:cd15434  103 CQPLHYTVVMHPRLCWKLVAMSWLIGFGnsLVLSPL 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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