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Conserved domains on  [gi|123890891|sp|Q1X6Y4|]
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RecName: Full=Neurotrophin-3; Short=NT-3; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
 5-113 6.89e-39

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


:

Pssm-ID: 437170  Cd Length: 114  Bit Score: 127.95  E-value: 6.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123890891    5 SMDQGBLSEDSMNSFIRTLIQAGIWKNKVPKQTARTKDGTQTAVKKTKAEPDVVANKD-RLGFQPIVSVDAELLRQQRRF 83
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENaKSDFQPVISLDTELLRQQRRY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 123890891   84 SSPRVLLSENTPLEPPPLYLTEE----PMGLNRT 113
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDfvgnSPVGNRT 114
NGF super family cl02481
Nerve growth factor family;
124-161 2.29e-19

Nerve growth factor family;


The actual alignment was detected with superfamily member pfam00243:

Pssm-ID: 470588  Cd Length: 112  Bit Score: 78.15  E-value: 2.29e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 123890891  124 SHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRM 161
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKT 38
 
Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
 5-113 6.89e-39

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


Pssm-ID: 437170  Cd Length: 114  Bit Score: 127.95  E-value: 6.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123890891    5 SMDQGBLSEDSMNSFIRTLIQAGIWKNKVPKQTARTKDGTQTAVKKTKAEPDVVANKD-RLGFQPIVSVDAELLRQQRRF 83
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENaKSDFQPVISLDTELLRQQRRY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 123890891   84 SSPRVLLSENTPLEPPPLYLTEE----PMGLNRT 113
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDfvgnSPVGNRT 114
NGF pfam00243
Nerve growth factor family;
124-161 2.29e-19

Nerve growth factor family;


Pssm-ID: 459728  Cd Length: 112  Bit Score: 78.15  E-value: 2.29e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 123890891  124 SHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRM 161
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKT 38
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
 124-162 2.65e-17

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


Pssm-ID: 128445  Cd Length: 106  Bit Score: 72.91  E-value: 2.65e-17
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 123890891   124 SHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRMG 162
Cdd:smart00140   1 SHRGEYSVCDSISVWVTDKTTATDISGNEVTVLGEVPVN 39
 
Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
 5-113 6.89e-39

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


Pssm-ID: 437170  Cd Length: 114  Bit Score: 127.95  E-value: 6.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123890891    5 SMDQGBLSEDSMNSFIRTLIQAGIWKNKVPKQTARTKDGTQTAVKKTKAEPDVVANKD-RLGFQPIVSVDAELLRQQRRF 83
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENaKSDFQPVISLDTELLRQQRRY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 123890891   84 SSPRVLLSENTPLEPPPLYLTEE----PMGLNRT 113
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDfvgnSPVGNRT 114
NGF pfam00243
Nerve growth factor family;
124-161 2.29e-19

Nerve growth factor family;


Pssm-ID: 459728  Cd Length: 112  Bit Score: 78.15  E-value: 2.29e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 123890891  124 SHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRM 161
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKT 38
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
 124-162 2.65e-17

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


Pssm-ID: 128445  Cd Length: 106  Bit Score: 72.91  E-value: 2.65e-17
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 123890891   124 SHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRMG 162
Cdd:smart00140   1 SHRGEYSVCDSISVWVTDKTTATDISGNEVTVLGEVPVN 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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