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Conserved domains on  [gi|121941436|sp|Q2M2I5|]
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RecName: Full=Keratin, type I cytoskeletal 24; AltName: Full=Cytokeratin-24; Short=CK-24; AltName: Full=Keratin-24; Short=K24; AltName: Full=Type I keratin-24

Protein Classification

intermediate filament family protein( domain architecture ID 11981676)

intermediate filament (IF) family protein is a primordial component of the cytoskeleton and the nuclear envelope; such as type I keratins

CATH:  1.20.5.170
Gene Ontology:  GO:0005882
PubMed:  2183847|12596228|28101862

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
140-452 5.58e-127

Intermediate filament protein;


:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 373.10  E-value: 5.58e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  140 EKQTMQNLNDRLANYLDKVRALEEANTDLENKIKEWYDKygpgsGDGGSGRDYSKYYSIIEDLRNQIIAATVENAGIILH 219
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQK-----KGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  220 IDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEEMKNMQGS-SGGEV 298
Cdd:pfam00038  77 LDNLRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQvSDTQV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  299 TVEMNAAPGTDLTKLLNDMRAQYEELAEQNRREAEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQ 378
Cdd:pfam00038 157 NVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121941436  379 LAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLDGE 452
Cdd:pfam00038 237 KKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGE 310
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
140-452 5.58e-127

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 373.10  E-value: 5.58e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  140 EKQTMQNLNDRLANYLDKVRALEEANTDLENKIKEWYDKygpgsGDGGSGRDYSKYYSIIEDLRNQIIAATVENAGIILH 219
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQK-----KGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  220 IDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEEMKNMQGS-SGGEV 298
Cdd:pfam00038  77 LDNLRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQvSDTQV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  299 TVEMNAAPGTDLTKLLNDMRAQYEELAEQNRREAEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQ 378
Cdd:pfam00038 157 NVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121941436  379 LAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLDGE 452
Cdd:pfam00038 237 KKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGE 310
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 241-450 1.49e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 1.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   241 RQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEemknmqgssgGEVTVEMNAAPGTDLTKLLNDMRAQ 320
Cdd:TIGR02168  276 VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEE----------LEAQLEELESKLDELAEELAELEEK 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   321 YEELAEQ--NRREAEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADT------ 392
Cdd:TIGR02168  346 LEELKEEleSLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLqqeiee 425

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   393 --EAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLD 450
Cdd:TIGR02168  426 llKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELA 485
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 242-490 2.72e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 242 QSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEEMKNMQ--GSSGGEVTVEMNAapgTDLTKLLNDMRA 319
Cdd:COG3883   47 EELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYrsGGSVSYLDVLLGS---ESFSDFLDRLSA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 320 qYEELAEQNRREAEERfnkqsASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQ 399
Cdd:COG3883  124 -LSKIADADADLLEEL-----KADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQ 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 400 LSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLDGEGGGSSFAEFGGRNSGSVNMGSRDLVSG 479
Cdd:COG3883  198 LAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAGAAGAAAGAAGAGAA 277

                        250
                 ....*....|.
gi 121941436 480 DSRSGSCSGQG 490
Cdd:COG3883  278 AASAAGGGAGG 288
46 PHA02562
endonuclease subunit; Provisional
 219-414 1.01e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.01  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 219 HIDNARLAA----DDFRLKYENELCLRQSVEADINGLRK--------------VLDDLTMTRSDLEMQIESFTEELAYLR 280
Cdd:PHA02562 203 NIEEQRKKNgeniARKQNKYDELVEEAKTIKAEIEELTDellnlvmdiedpsaALNKLNTAAAKIKSKIEQFQKVIKMYE 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 281 KNHEEEmKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQnrreaEERFNKQSAS---LQAQISTDAGAATSA 357
Cdd:PHA02562 283 KGGVCP-TCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEI-----MDEFNEQSKKlleLKNKISTNKQSLITL 356

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121941436 358 KNEITELKRTLQaleiELQSQLAMKsslegtlADTEAGYVAQLSEIQTQISALEEEI 414
Cdd:PHA02562 357 VDKAKKVKAAIE----ELQAEFVDN-------AEELAKLQDELDKIVKTKSELVKEK 402
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
140-452 5.58e-127

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 373.10  E-value: 5.58e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  140 EKQTMQNLNDRLANYLDKVRALEEANTDLENKIKEWYDKygpgsGDGGSGRDYSKYYSIIEDLRNQIIAATVENAGIILH 219
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQK-----KGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  220 IDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEEMKNMQGS-SGGEV 298
Cdd:pfam00038  77 LDNLRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQvSDTQV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  299 TVEMNAAPGTDLTKLLNDMRAQYEELAEQNRREAEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQ 378
Cdd:pfam00038 157 NVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 121941436  379 LAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLDGE 452
Cdd:pfam00038 237 KKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGE 310
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 241-450 1.49e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 1.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   241 RQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEemknmqgssgGEVTVEMNAAPGTDLTKLLNDMRAQ 320
Cdd:TIGR02168  276 VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEE----------LEAQLEELESKLDELAEELAELEEK 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   321 YEELAEQ--NRREAEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADT------ 392
Cdd:TIGR02168  346 LEELKEEleSLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLqqeiee 425

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   393 --EAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLD 450
Cdd:TIGR02168  426 llKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELA 485
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 242-490 2.72e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 242 QSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEEMKNMQ--GSSGGEVTVEMNAapgTDLTKLLNDMRA 319
Cdd:COG3883   47 EELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYrsGGSVSYLDVLLGS---ESFSDFLDRLSA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 320 qYEELAEQNRREAEERfnkqsASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQ 399
Cdd:COG3883  124 -LSKIADADADLLEEL-----KADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQ 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 400 LSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLDGEGGGSSFAEFGGRNSGSVNMGSRDLVSG 479
Cdd:COG3883  198 LAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAGAAGAAAGAAGAGAA 277

                        250
                 ....*....|.
gi 121941436 480 DSRSGSCSGQG 490
Cdd:COG3883  278 AASAAGGGAGG 288
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 312-452 8.08e-05

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 43.99  E-value: 8.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  312 KLLNDMRAQYEELaEQNRREAEERFNKQSASLQAQIstdagaaTSAKNEITELKRTLQALEielqsqlamksslegtlad 391
Cdd:pfam14988  22 KLWNQYVQECEEI-ERRRQELASRYTQQTAELQTQL-------LQKEKEQASLKKELQALR------------------- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121941436  392 teagYVAQLSEIQTQ-ISALEEEICQIWGETKCQNAEYK-QLLDIKTRLEVEIETYRRLLDGE 452
Cdd:pfam14988  75 ----PFAKLKESQEReIQDLEEEKEKVRAETAEKDREAHlQFLKEKALLEKQLQELRILELGE 133
46 PHA02562
endonuclease subunit; Provisional
 219-414 1.01e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.01  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 219 HIDNARLAA----DDFRLKYENELCLRQSVEADINGLRK--------------VLDDLTMTRSDLEMQIESFTEELAYLR 280
Cdd:PHA02562 203 NIEEQRKKNgeniARKQNKYDELVEEAKTIKAEIEELTDellnlvmdiedpsaALNKLNTAAAKIKSKIEQFQKVIKMYE 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 281 KNHEEEmKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQnrreaEERFNKQSAS---LQAQISTDAGAATSA 357
Cdd:PHA02562 283 KGGVCP-TCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEI-----MDEFNEQSKKlleLKNKISTNKQSLITL 356

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121941436 358 KNEITELKRTLQaleiELQSQLAMKsslegtlADTEAGYVAQLSEIQTQISALEEEI 414
Cdd:PHA02562 357 VDKAKKVKAAIE----ELQAEFVDN-------AEELAKLQDELDKIVKTKSELVKEK 402
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 137-452 7.44e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 7.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   137 SGGEKQTMQNLNDRLANYLDKVRALEEANTDLENKIKEWYDKYGPGSGDGGSGRDyskyysIIEDLRNQIIAATVENAGI 216
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRK------ELEELSRQISALRKDLARL 738

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   217 ILHIDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNH---EEEMKNMQGS 293
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALdelRAELTLLNEE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   294 SG-GEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQnrreaEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALE 372
Cdd:TIGR02168  819 AAnLRERLESLERRIAATERRLEDLEEQIEELSED-----IESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   373 IELQSQLAMKSSLEGTLADTEAGYVA---QLSEIQTQISALEEEICQIWGETkcqNAEYKQLLDIKTRLEVEIETYRRLL 449
Cdd:TIGR02168  894 SELEELSEELRELESKRSELRRELEElreKLAQLELRLEGLEVRIDNLQERL---SEEYSLTLEEAEALENKIEDDEEEA 970


                   ...
gi 121941436   450 DGE 452
Cdd:TIGR02168  971 RRR 973
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 242-414 1.05e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 242 QSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAylrkNHEEEMKNMQgssggevtvemnaapgTDLTKLLNDMRAQY 321
Cdd:COG1579   13 QELDSELDRLEHRLKELPAELAELEDELAALEARLE----AAKTELEDLE----------------KEIKRLELEIEEVE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 322 EELAEQNRREAEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQLS 401
Cdd:COG1579   73 ARIKKYEEQLGNVRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELA 152

                        170
                 ....*....|...
gi 121941436 402 EIQTQISALEEEI 414
Cdd:COG1579  153 ELEAELEELEAER 165
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 225-464 1.17e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 225 LAADDFRLKYENELclrQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRK---NHEEEMKNMQGssggevtvE 301
Cdd:COG4942   16 AAQADAAAEAEAEL---EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARrirALEQELAALEA--------E 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 302 MNAApGTDLTKLLNDMRAQYEELAEQ--------NRREAEERFNKQSASLQAQISTDAGAATSA-KNEITELKRT---LQ 369
Cdd:COG4942   85 LAEL-EKEIAELRAELEAQKEELAELlralyrlgRQPPLALLLSPEDFLDAVRRLQYLKYLAPArREQAEELRADlaeLA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 370 ALEIELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRll 449
Cdd:COG4942  164 ALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE-- 241

                        250
                 ....*....|....*
gi 121941436 450 dgEGGGSSFAEFGGR 464
Cdd:COG4942  242 --RTPAAGFAALKGK 254
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 309-444 1.46e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.59  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   309 DLTKLLNDMRAQYEELAEQnrreaEERFNKQSASLQAQIStdagaatSAKNEITELKRTLQALEIELQSQLAMKSSLEGT 388
Cdd:TIGR02169  713 DASRKIGEIEKEIEQLEQE-----EEKLKERLEELEEDLS-------SLEQEIENVKSELKELEARIEELEEDLHKLEEA 780

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 121941436   389 LADTEAGYV-AQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIET 444
Cdd:TIGR02169  781 LNDLEARLShSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQE 837
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 199-414 1.73e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 199 IEDLRNQIIAATVENAGIILHIDNARLAADDFRLKYENElclrqsvEADINGLRKVLDDLTMTRSDLEMQIESFTEELAY 278
Cdd:COG1196  241 LEELEAELEELEAELEELEAELAELEAELEELRLELEEL-------ELELEEAQAEEYELLAELARLEQDIARLEERRRE 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 279 LRKNHEEEMKNMQgssggevtvemnaapgtDLTKLLNDMRAQYEELAEQNRREAEERfnKQSASLQAQISTDAGAATSAK 358
Cdd:COG1196  314 LEERLEELEEELA-----------------ELEEELEELEEELEELEEELEEAEEEL--EEAEAELAEAEEALLEAEAEL 374

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121941436 359 NEITELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEI 414
Cdd:COG1196  375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL 430
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 265-450 1.83e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 41.26  E-value: 1.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   265 LEMQIESFTEE----LAYLRKNHEEEMKnmQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQNRreaeerfnKQS 340
Cdd:pfam15921  243 VEDQLEALKSEsqnkIELLLQQHQDRIE--QLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQAR--------NQN 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436   341 ASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSlEGTLADTEAGYVAQLS-EIQTQISALEEEICQIWG 419
Cdd:pfam15921  313 SMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANS-ELTEARTERDQFSQESgNLDDQLQKLLADLHKREK 391

                          170       180       190
                   ....*....|....*....|....*....|.
gi 121941436   420 ETKCQNAEYKQLLDIKTRLEVEIETYRRLLD 450
Cdd:pfam15921  392 ELSLEKEQNKRLWDRDTGNSITIDHLRRELD 422
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
190-450 2.18e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 40.77  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 190 RDYSKYYSIIEDLRNQIIAATVENAGIIlHI----DNARLAAddfrlKYENELC---LRQSVEADINGLRKVLDDLTMTR 262
Cdd:COG3206  111 GEEASREAAIERLRKNLTVEPVKGSNVI-EIsytsPDPELAA-----AVANALAeayLEQNLELRREEARKALEFLEEQL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 263 SDLEMQIESFTEELAYLRKNHeeemknmqgssgGEVTVEMNAapgTDLTKLLNDMRAQYEElAEQNRREAEERFNkqsaS 342
Cdd:COG3206  185 PELRKELEEAEAALEEFRQKN------------GLVDLSEEA---KLLLQQLSELESQLAE-ARAELAEAEARLA----A 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 343 LQAQISTDAGAATSAKNEitelkRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETK 422
Cdd:COG3206  245 LRAQLGSGPDALPELLQS-----PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILASLE 319

                        250       260
                 ....*....|....*....|....*...
gi 121941436 423 cqnAEYKQLLDIKTRLEVEIETYRRLLD 450
Cdd:COG3206  320 ---AELEALQAREASLQAQLAQLEARLA 344
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 199-443 3.45e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.00  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  199 IEDLRNQIIAATVENAGIILHIDNARLAaddfRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAY 278
Cdd:TIGR04523 168 KEELENELNLLEKEKLNIQKNIDKIKNK----LLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINE 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  279 LR---KNHEEEMKNMQGSSGGEVT--------VEMNAAPGTDLTKLLNDMRAQYEELAEQNRREAEERFNKQSAS----- 342
Cdd:TIGR04523 244 KTteiSNTQTQLNQLKDEQNKIKKqlsekqkeLEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNqekkl 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436  343 --LQAQISTDAGAATSAKNEITELKRTLQALE---IELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQI 417
Cdd:TIGR04523 324 eeIQNQISQNNKIISQLNEQISQLKKELTNSEsenSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQ 403

                         250       260
                  ....*....|....*....|....*.
gi 121941436  418 WGETKCQNAEYKQLLDIKTRLEVEIE 443
Cdd:TIGR04523 404 EKLNQQKDEQIKKLQQEKELLEKEIE 429
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
141-414 9.83e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.84  E-value: 9.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 141 KQTMQNLNDRLANYLDKVRALEEAntdlenkikewydkygpgsgdggsgrdyskyysiIEDLRNQiiaatvenAGIIlhi 220
Cdd:COG3206  174 RKALEFLEEQLPELRKELEEAEAA----------------------------------LEEFRQK--------NGLV--- 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 221 dnarlaaddfrlkyenelclrqSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKnheeemknmQGSSGGEVTV 300
Cdd:COG3206  209 ----------------------DLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRA---------QLGSGPDALP 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121941436 301 EMNAAPgtdltkLLNDMRAQYEELaEQNRREAEERFNKQS---ASLQAQIStdagaatSAKNEI-TELKRTLQALEIELQ 376
Cdd:COG3206  258 ELLQSP------VIQQLRAQLAEL-EAELAELSARYTPNHpdvIALRAQIA-------ALRAQLqQEAQRILASLEAELE 323

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121941436 377 SQLAMKSSLEGTLADTEAgYVAQLSEIQTQISALEEEI 414
Cdd:COG3206  324 ALQAREASLQAQLAQLEA-RLAELPELEAELRRLEREV 360
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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