|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-863 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1492.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 1 MAYPFHDIETKWQQYWEEHQTFRTPDevPDDQEEFYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGW 80
Cdd:COG0495 3 ERYNPKEIEKKWQKYWEENGTFKADE--DSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPMGW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 81 DAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWC 160
Cdd:COG0495 80 DAFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWC 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 161 EELGTVLANEEVIDGKSERGGYPCERVPMRQWVLKITEYADRLLEGLEDLD-WPESTKEMQRNWIGRSEGANVYFDLVGA 239
Cdd:COG0495 160 PVDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 240 DDALEVYTTRPDTLFGATYMVLAPEHELLDEITTDEHREDVDEYCRQALRKSERKRQQ-QGDKTGVFTGGYAVNPVNGEE 318
Cdd:COG0495 240 DEKITVFTTRPDTLFGATFMVLAPEHPLVKELATPEQNAAVAAFIEEAKKKSEIERTSeTKEKTGVFTGLYAINPLTGEK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 319 IPIWVADYVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVVEGGDID-----EEAYTGDGPHVHSAneavSLNGLRNE 393
Cdd:COG0495 320 IPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDdpdilEEAYTGDGVLINSG----EFDGLDSE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 394 EAKEAITEWLDEEEKGERTVNYQLQDWLFSRQRYWGEPFPIVFTEDGEDKPVPEEELPVTLPDLDVFEPSGTPegPLATI 473
Cdd:COG0495 396 EAKEAIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTGGS--PLARA 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 474 EDWRETTDPETGEPAQRETNTMPQWAGSCWYYLRFIDPDNDEQLVDPEKEEYWMPVDLYVGGSEHAVLHLLYARFWHKVL 553
Cdd:COG0495 474 PEWVNVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 554 YDAGVVSTKEPFQTLVHQGMILgeteytayrddagefvsaeQVDDDAdltpvpvddgdvkkdgdvfvladrpavRVDARS 633
Cdd:COG0495 554 RDLGLVSFDEPFKRLLTQGMVL-------------------EVGKDG---------------------------VVIGGI 587
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 634 HKMSKSRGNVINPDDVVDEYGADTLRLYEMFMGPLEQDKPWSTDDMEGVHRFLNRIWRLVVD-ADSGGLAVSD-EEPDRE 711
Cdd:COG0495 588 EKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDeAEALKLDVADlSEADKE 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 712 QLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANKWD-------ALPRQVATPFVLLLSPFAPHLAEELWARLGHDQS 784
Cdd:COG0495 668 LRRALHKTIKKVTEDIERLRFNTAIAALMELVNALYKAKdsgeadrAVLREALETLVLLLAPFAPHIAEELWERLGHEGS 747
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123753431 785 LAYADWPAYDDELIRREVVEMPVQVDGTVRATIEVAADAEEADVLATAKEAENVARHLDDEDLQREIYVPGQIVNFVTG 863
Cdd:COG0495 748 VADAPWPEADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
2-863 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 1481.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 2 AYPFHDIETKWQQYWEEHQTFRTPDEVPDDQEEFYVLDMFPYPSGSGLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWD 81
Cdd:PLN02563 79 AYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWD 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 82 AFGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWCE 161
Cdd:PLN02563 159 AFGLPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCP 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 162 ELGTVLANEEVIDGKSERGGYPCERVPMRQWVLKITEYADRLLEGLEDLDWPESTKEMQRNWIGRSEGANVYFDLVG--- 238
Cdd:PLN02563 239 ALGTVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVLDgeg 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 239 --ADDALEVYTTRPDTLFGATYMVLAPEHELLDEITTDEHREDVDEYCRQALRKSERKRQQ-QGDKTGVFTGGYAVNPVN 315
Cdd:PLN02563 319 keRDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTElQKEKTGVFTGSYAINPAT 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 316 GEEIPIWVADYVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVVEGGDID----EEAYTGDGPHVHSANEAVSLNGLR 391
Cdd:PLN02563 399 GEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNeddaEKAYTGEGVIVNSSSSGLDINGLS 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 392 NEEAKEAITEWLDEEEKGERTVNYQLQDWLFSRQRYWGEPFPIVFTED-GEDKPVPEEELPVTLPDLDVFEPSGTPEGPL 470
Cdd:PLN02563 479 SKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDsGEPVPVPESDLPLTLPELDDFTPTGTGEPPL 558
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 471 ATIEDWRETTDPETGEPAQRETNTMPQWAGSCWYYLRFIDPDNDEQLVDPEKEEYWMPVDLYVGGSEHAVLHLLYARFWH 550
Cdd:PLN02563 559 AKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWH 638
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 551 KVLYDAGVVSTKEPFQTLVHQGMILGETEYTAYRDDAGEFVSAEQVDDDADLTPVPVDDGDVKKDGDVFVLADRPAVRVD 630
Cdd:PLN02563 639 KVLYDIGVVSTKEPFQCLVNQGMILGEVEYTAFKDSDGEYVSADTADRLGELQQEKIPEEKVIKSGDSFVLKDDPSIRLI 718
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 631 ARSHKMSKSRGNVINPDDVVDEYGADTLRLYEMFMGPLEQDKPWSTDDMEGVHRFLNRIWRLVVDAD------SGGLAVS 704
Cdd:PLN02563 719 ARAHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVGAPlpdgsfRDGTVVT 798
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 705 DEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANKWDALPRQVATPFVLLLSPFAPHLAEELWARLGHDQS 784
Cdd:PLN02563 799 DEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKWDKVPREAIEPFVLLLSPYAPHLAEELWFRLGHSNS 878
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123753431 785 LAYADWPAYDDELIRREVVEMPVQVDGTVRATIEVAADAEEADVLATAKEAENVARHLDDEDLQREIYVPGQIVNFVTG 863
Cdd:PLN02563 879 LAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVPGKILNVILK 957
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
3-861 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1169.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 3 YPFHDIETKWQQYWEEHQTFRTPDEvpDDQEEFYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDA 82
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDD--SSKPKYYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 83 FGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWCEE 162
Cdd:TIGR00396 78 FGLPAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 163 LGTVLANEEVI-DGKSERGGYPCERVPMRQWVLKITEYADRLLEGLEDLD-WPESTKEMQRNWIGRSEGANVYFDLVGAD 240
Cdd:TIGR00396 158 DGTVLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIADHD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 241 DALEVYTTRPDTLFGATYMVLAPEHELLDEITTDEhrEDVDEYCRQALRKSERKRQ-QQGDKTGVFTGGYAVNPVNGEEI 319
Cdd:TIGR00396 238 EKITVFTTRPDTIFGVTYLALAPEHPLVEKAAENN--PKVAAFIKKILNKTVAERTkATKEKKGVDTGIKAIHPLTGEKI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 320 PIWVADYVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVVEGGDID---EEAYTGDGPHVHSAneavSLNGLRNEEAK 396
Cdd:TIGR00396 316 PIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDlslTAAYTEDGVLVNSG----EFNGLNSSEAR 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 397 EAITEWLDEEEKGERTVNYQLQDWLFSRQRYWGEPFPIVFTEDGEDKPVPEEELPVTLPDLDVFEPSGTPegPLATIEDW 476
Cdd:TIGR00396 392 NAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGGS--PLSRIPEW 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 477 RETTDPETGEPAQRETNTMPQWAGSCWYYLRFIDPDNDEQLVDPEKEEYWMPVDLYVGGSEHAVLHLLYARFWHKVLYDA 556
Cdd:TIGR00396 470 VNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDI 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 557 GVVSTKEPFQTLVHQGMILGETEYTAYRDDAGEFVSAEQVDDDADLTPVPVDDGDvkkdgdvfvladrpavrvdarshKM 636
Cdd:TIGR00396 550 GYVNTKEPFKKLINQGMVLGFYYPPNGKVPADVLTERDEKGKDKAGGELVYVGYE-----------------------KM 606
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 637 SKSRGNVINPDDVVDEYGADTLRLYEMFMGPLEQDKPWSTDDMEGVHRFLNRIWRLVVDADSGGLAVSD-----EEPDRE 711
Cdd:TIGR00396 607 SKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLtvtalEEAQKE 686
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 712 QLRTLHRTIKTVTEDIE-ARDFNTAIAAMMEFVNAANKW--DALPRQVATPFVLLLSPFAPHLAEELWARLGHDQSLAY- 787
Cdd:TIGR00396 687 LRRDVHKFLKKVTEDLEkRESFNTAISAMMELLNKLYKAkkEALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFIIDn 766
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 123753431 788 ADWPAYDDELIRREVVEMPVQVDGTVRATIEVAADAEEADVLATAKEAENVARHLDDEDLQREIYVPGQIVNFV 861
Cdd:TIGR00396 767 AKWPVVDETALVEDKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFV 840
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
35-674 |
8.13e-120 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 365.42 E-value: 8.13e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 35 FYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLK 114
Cdd:cd00812 2 FYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 115 RLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWCeelgtvlaneevidgkserggypcerVPMRQWVL 194
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 195 KI--TEYADRLLEGLEDLD-WPEstkemqrnwigrseganvyfdlvgaddalevyttrpdtlfgatymvlapehelldei 271
Cdd:cd00812 135 KYseTEWKEKLLKDLEKLDgWPE--------------------------------------------------------- 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 272 ttdehredvdeycrqalrksERKRQQQGdktgvftggyavnpvngeeipiwvadyvlvsygtgaimavpahderdhafan 351
Cdd:cd00812 158 --------------------EVRAMQEN---------------------------------------------------- 165
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 352 kydlpirevveggdideeaytgdgphvhsaneavslnglrneeakeaiteWLDeeekgertvnyqlqdwlFSRQRYWGEP 431
Cdd:cd00812 166 --------------------------------------------------WIG-----------------CSRQRYWGTP 178
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 432 FPIvftedgedkpvpeeelpvtlpdldvfepsgtpegplatiedwrettdpetgepaqreTNTMPQWAGSCWYYLRFIDP 511
Cdd:cd00812 179 IPW---------------------------------------------------------TDTMESLSDSTWYYARYTDA 201
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 512 DNDEQLV------DPEKEEYWMPVDLYVGGSEHAVLHLLYARFWHKVLYDAGVVsTKEPFQTLVHQGMILGETEytayrd 585
Cdd:cd00812 202 HNLEQPYegdlefDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLLEGE------ 274
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 586 dagefvsaeqvdddadltpvpvddgdvkkdgdvfvladrpavrvdarshKMSKSRGNVINPDDVVDEYGADTLRLYEMFM 665
Cdd:cd00812 275 -------------------------------------------------KMSKSKGNVVTPDEAIKKYGADAARLYILFA 305
|
....*....
gi 123753431 666 GPLEQDKPW 674
Cdd:cd00812 306 APPDADFDW 314
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
2-798 |
3.39e-88 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 298.90 E-value: 3.39e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 2 AYPFHDIETKWQQYWEEHQTFRtPDEvpDDQEEFYVLDMFP-YPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGW 80
Cdd:TIGR00422 4 DYDPHEVEKKWYKKWEKSGFFK-PDG--NSNKPPFCIDIPPpNVTGS-LHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 81 DAFGLPAE-----QYALKTNTH---PRET--------TEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQL 144
Cdd:TIGR00422 80 DHAGIATQvkvekKLGAEGKTKhdlGREEfrekiwewKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 145 YEKGLAYQSEEPVWWCEELGTVLANEEVidgkserggypcervpmrqwvlkitEYADRllegledldwpestkEMQRNWI 224
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEV-------------------------EYKEV---------------KGKLYYI 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 225 grseganVYFDLVGADDALEVYTTRPDTLFGATYMVLAPEhelldeittDEHREDvdeycrqalrkserkrqqqgdktgv 304
Cdd:TIGR00422 200 -------RYPLANGSKDYLVVATTRPETMFGDTAVAVHPE---------DERYKH------------------------- 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 305 FTGGYAVNPVNGEEIPIWVADYVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVV-EGGDIDEEA--YTgdgphvhsa 381
Cdd:TIGR00422 239 LIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILdEDGLLNENAgkYQ--------- 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 382 neavslnGLRNEEAKEAITEWLDEE------EKGERTVNY---------------------------------------- 415
Cdd:TIGR00422 310 -------GLTRFEARKKIVEDLKEEgllvkiEPHTHNVGTcwrsgtvvepllskqwfvkvekladkaleaaeegeikfvp 382
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 416 ------------QLQDWLFSRQRYWGEPFPIVFTEDGEDKPVPEEELPVTLPdldvfepsgTPEGPLATIEdwrettdpe 483
Cdd:TIGR00422 383 krmekrylnwlrNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDK---------TNTGPSVELE--------- 444
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 484 tgepaqRETNTMPQWAGSCWYYLRFID-PDNDEQLvdpeKEEYwmPVDLYVGGseHAVLhllyaRFWhkVLYD--AGVVS 560
Cdd:TIGR00422 445 ------QDTDVLDTWFSSSLWPFSTLGwPDETKDL----KKFY--PTDLLVTG--YDII-----FFW--VARMifRSLAL 503
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 561 TKE-PFQTLVHQGMIlgeteytayRDDAGefvsaeqvdddadltpvpvddgdvkkdgdvfvladrpavrvdarsHKMSKS 639
Cdd:TIGR00422 504 TGQvPFKEVYIHGLV---------RDEQG---------------------------------------------RKMSKS 529
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 640 RGNVINPDDVVDEYGADTLRLYEMFMGPLEQDKPWSTDDMEGVHRFLNRIW---RLVVDADSGGLAVS-DEEP----DRE 711
Cdd:TIGR00422 530 LGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWnasRFVLMNLSDDLELSgGEEKlslaDRW 609
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 712 QLRTLHRTIKTVTEDIEARDFNTAIAAMMEFV-------------------NAANKWDAlpRQVATPF----VLLLSPFA 768
Cdd:TIGR00422 610 ILSKLNRTIKEVRKALDKYRFAEAAKALYEFIwndfcdwyielvkyrlyngNEAEKKAA--RDTLYYVldkaLRLLHPFM 687
|
890 900 910
....*....|....*....|....*....|.
gi 123753431 769 PHLAEELWARLGHD-QSLAYADWPAYDDELI 798
Cdd:TIGR00422 688 PFITEEIWQHFKEGaDSIMLQSYPVVDAEFV 718
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
3-853 |
6.41e-85 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 288.63 E-value: 6.41e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 3 YPFHDIETKWQQYWEEHQTFRTPdevPDDQEEFYVLDMFP-YPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWD 81
Cdd:PRK13208 10 YDPEELEEKWQKIWEEEGTYKFD---PDERKPVYSIDTPPpTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 82 AFGLPAE---QYALKTNTHP----------RETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKG 148
Cdd:PRK13208 86 DNGLPTErkvEKYYGIRKDDisreefielcRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 149 LAYQSEEPVWWCEELGTVLANEEVidgkserggypcervpmrqwvlkitEYADRllegledldwpestkemqrnwigrsE 228
Cdd:PRK13208 166 LIYRAEAPVLWCPRCETAIAQAEV-------------------------EYRER-------------------------E 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 229 GANVY--FDLVGADDaLEVYTTRPDtLFGATYMVLApehelldeittdeHREDvdeycrqalrksERKRQqqgdktgvFT 306
Cdd:PRK13208 196 GKLNYikFPVEDGEE-IEIATTRPE-LLPACVAVVV-------------HPDD------------ERYKH--------LV 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 307 GGYAVNPVNGEEIPIwVAD-YVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVV-EGGDIDEEAytgdGPhvhsanea 384
Cdd:PRK13208 241 GKTAIVPLFGVEVPI-LADpLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIdEDGRMTEAA----GK-------- 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 385 vsLNGLRNEEAKEAITEWLDEE------EKGERTVNY-------------------QLQ--------------------- 418
Cdd:PRK13208 308 --LAGLTIEEARKKIVEDLKSGgllgkqEPIKHNVKFcercdtpleilvtrqwfikVLDlkeellergkeinwypehmrv 385
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 419 -----------DWLFSRQRYWGEPFPIVFTEDgEDKPVP--EEELPVTlPDLDVfepsgtPEGPlatiedwretTDPETG 485
Cdd:PRK13208 386 rlenwieglnwDWCISRQRYFGTPIPVWYCKD-CGHPILpdEEDLPVD-PTKDE------PPGY----------KCPQCG 447
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 486 ----EPaqrETNTMPQWAGSCwyylrfIDPdndeQLV-----DPEKEEYWMPVDLYVGGseHAVLhllyaRFWH-----K 551
Cdd:PRK13208 448 spgfEG---ETDVMDTWATSS------ITP----LIVtgwerDEDLFEKVFPMDLRPQG--HDII-----RTWLfytilR 507
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 552 VLYDAGVVstkePFQTLVHQGMILGEteytayrddagefvsaeqvdddadltpvpvddgdvkkdgdvfvlaDRpavrvda 631
Cdd:PRK13208 508 AYLLTGKL----PWKNIMISGMVLDP---------------------------------------------DG------- 531
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 632 rsHKMSKSRGNVINPDDVVDEYGADTLRlYEMFMGPLEQDKPWSTDDMEGVHRFLNRIW---RLVVDADSGGLAVSDE-- 706
Cdd:PRK13208 532 --KKMSKSKGNVVTPEELLEKYGADAVR-YWAASARLGSDTPFDEKQVKIGRRLLTKLWnasRFVLHFSADPEPDKAEvl 608
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 707 EP-DREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFV-----------------NAANKWDALPRQVATPFVL-----L 763
Cdd:PRK13208 609 EPlDRWILAKLAKVVEKATEALENYDFAKALEEIESFFwhvfcddylelvksrayGEDEEEEQKSARYTLYTVLdtllrL 688
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 764 LSPFAPHLAEELWARLgHDQSLAYADWPAYDDELIRREVVEMP---VQVDGTVR--------------ATIEVAADAE-- 824
Cdd:PRK13208 689 LAPFLPFITEEVWSWL-YGGSVHRASWPEPDEELIDEEDEELGelaKEILSAVRkykseaglslnaplKKVEVYGPADle 767
|
970 980 990
....*....|....*....|....*....|....
gi 123753431 825 -----EADVLATAKeAENVARHLDDEDLQREIYV 853
Cdd:PRK13208 768 lleaaEEDLKAAGN-IEELELVEGDPELEVEIIA 800
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
221-403 |
1.95e-84 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 267.49 E-value: 1.95e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 221 RNWIGRSEGANVYFDLVGADDALEVYTTRPDTLFGATYMVLAPEHELLDEITtdEHREDVDEYCRQALRKSERKRQQQG- 299
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLA--EKNPEVAAFIEECKNTSEIERTSETk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 300 DKTGVFTGGYAVNPVNGEEIPIWVADYVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVVEGGD------IDEEAYTG 373
Cdd:pfam13603 79 EKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDgdldldIMTEAYTE 158
|
170 180 190
....*....|....*....|....*....|
gi 123753431 374 DGPHVHSAneavSLNGLRNEEAKEAITEWL 403
Cdd:pfam13603 159 EGILVNSG----EFDGLDSEEAKEAIIKKL 184
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
49-802 |
9.11e-61 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 222.44 E-value: 9.11e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 49 LHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLP----AEQYA--------LKTNTH--PRETTEK-----NIAQF 109
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERIArgdpetieLYKSLYgiPEEELEKfkdpeYIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 110 -----KRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWCEELGTVLANEEVIDGkserggypc 184
Cdd:PRK12300 81 fseeaKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG--------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 185 ERVPMRQWVL-KITEYADrllegledldwpestkemqrnwigrseganvyFDLVGAddalevyTTRPDTLFGATYMVLAP 263
Cdd:PRK12300 152 EEPEIVEYTLiKFEESED--------------------------------LILPAA-------TLRPETIFGVTNLWVNP 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 264 EHELLdEITTDEHREDVDEYCRQALRKSERKRQQQGD-KTGVFTGGYAVNPVNGEEIPIWVADYVLVSYGTGAIMAVPAH 342
Cdd:PRK12300 193 DATYV-KAEVDGEKWIVSKEAAEKLSFQDRDVEIIEEiKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAH 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 343 DERDHA-----FANKYDL-----------------PIREVVEGGDI----DE--EAYTGDgphVHSA--------NEAVS 386
Cdd:PRK12300 272 APYDYValrdlKKNKELLdviepiplievegygefPAKEVVEKLGIksqeDPelEEATKE---VYRAefhkgvlkENTGE 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 387 LNGLRNEEAKEAITEWLDEEEKGE----------------RTV----------NYQ------------------------ 416
Cdd:PRK12300 349 YAGKPVREAREKITKDLIEKGIADimyefsnrpvycrcgtECVvkvvkdqwfiDYSdpewkelahkaldnmeiipeeyrk 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 417 --------LQDWLFSRQRYWGEPFP----------------------IVFTEDGEDKPvpeEELPVTLPDLdVFEPSGTP 466
Cdd:PRK12300 429 efentidwLKDRACARRRGLGTRLPwdeewiieslsdstiymayytiAHKIREYGIKP---EQLTPEFFDY-VFLGKGDP 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 467 EgplaTIEDwrettdpETGEPAqretntmpqwagscwyylrfidpdndEQLVDPEKE-EYWMPVDLYVGGSEHAVLHLLY 545
Cdd:PRK12300 505 E----EVSK-------KTGIPK--------------------------EILEEMREEfLYWYPVDWRHSGKDLIPNHLTF 547
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 546 ARFWHKVLYDagvvSTKEPFQTLVHqGMILGEteytayrddaGEfvsaeqvdddadltpvpvddgdvkkdgdvfvladrp 625
Cdd:PRK12300 548 FIFNHVAIFP----EEKWPRGIVVN-GFVLLE----------GK------------------------------------ 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 626 avrvdarshKMSKSRGNVINPDDVVDEYGADTLRLYEMFMGPLEQDKPWSTDDMEGVHRFLNRIWRLVVDADSGGLAVSD 705
Cdd:PRK12300 577 ---------KMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAKELIEIGGEEEL 647
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 706 EEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAM-----------MEFVNAANKwdALPRQVATPFVLLLSPFAPHLAEE 774
Cdd:PRK12300 648 RFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAfyellndlrwyLRRVGEANN--KVLREVLEIWIRLLAPFTPHLAEE 725
|
890 900
....*....|....*....|....*...
gi 123753431 775 LWARLGHDQSLAYADWPAYDDELIRREV 802
Cdd:PRK12300 726 LWHKLGGEGFVSLEKWPEPDESKIDEEA 753
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
11-661 |
4.82e-60 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 214.97 E-value: 4.82e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 11 KWQQYWEEHQTFRTPDEVPDDQEEFYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQY 90
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGS-LHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 91 ALKT-----------------NTHPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQS 153
Cdd:pfam00133 80 VEKKlgikekktrhkygreefREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 154 EEPVWWCEELGTVLANEEVidgkserggypcervpmrqwvlkitEYADrllegledldwpestkemqrnwigrSEGANVY 233
Cdd:pfam00133 160 KKLVNWSPALNTALSNLEV-------------------------EYKD-------------------------VKGPSIH 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 234 --FDLVGADDA-LEVYTTRPDTLFGATYMVLAPEhelLDEITTDEHREDVDEYCRQALRKSERKRQQQGDKTGVFTGGYA 310
Cdd:pfam00133 190 vaFPLADDEGAsLVIWTTTPWTLPGNTAVAVNPE---FDYVITGEGYILAEALLKSLYKKGTDKKILEDFRGKELEGKEA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 311 VNPVNGEEIPIWVADYVLVSYGTGAIMAVPAHDERDHAFANKYDLP-IREVVEGGDIDEEAYTGDGPHVHSANEAV--SL 387
Cdd:pfam00133 267 IHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEvINPVDDDGTFTEEAPDFQGVYRFDARKKIveLL 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 388 NGLRNEEAKE-------------------AITEW-----------LDEEEK-------GERTVNYQL---QDWLFSRQRY 427
Cdd:pfam00133 347 TEKGLLLKIEpfthsypfcwrsgtpiiprATPQWfvrmdeladqaLEAVEKvqfvpksGEKRYFNWLaniQDWCISRQRW 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 428 WGEPFPIVFTEDGedkpvpEEELPVTlpdlDVFEPSGTPEGPLATIEDWRETTDPETGEPA---QRETNTMPQW--AGSc 502
Cdd:pfam00133 427 WGHPIPAWVSKDT------EEVVCRG----ELFELVAGRFEEEGSIKWLHREAKDKLGYGKgtlEQDEDVLDTWfsSGS- 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 503 WYYLRFIDPDNDEqlvdPEKEEYWmPVDLYVGGSEHavlhllyARFWhkvLYDAGVVSTK----EPFQTLVHQGMILget 578
Cdd:pfam00133 496 WPFSTLGWPFVNT----EEFKKFF-PADMLLEGSDQ-------TRGW---FYRMIMLSTAltgsVPFKNVLVHGLVR--- 557
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 579 eytayrddagefvsaeqvdddadltpvpvddgdvkkdgdvfvladrpavrvDARSHKMSKSRGNVINPDDVVDEYGADTL 658
Cdd:pfam00133 558 ---------------------------------------------------DEQGRKMSKSLGNVIDPLDVIDKYGADAL 586
|
...
gi 123753431 659 RLY 661
Cdd:pfam00133 587 RLW 589
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
1-818 |
8.66e-59 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 216.09 E-value: 8.66e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 1 MAYPFHDIETKWQQYWEEHQTFRTPDEVPDDQEEFYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGW 80
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGS-IHLGHALNKILKDIILRYKTMQGFNVTRKPGW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 81 DAFGLPAEQYALKT-----------------NTHPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQ 143
Cdd:TIGR00392 83 DTHGLPIEHKVEKKlgisgkkeissleieefREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 144 LYEKGLAYQSEEPVWWCEELGTVLANEEVidgkserggypcervpmrqwvlkitEYadrllegledldwPESTKEMqrnw 223
Cdd:TIGR00392 163 AHEKGLLYRGLKPVYWSPRCRTALAEAEV-------------------------EY-------------KENYKDV---- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 224 igRSEGANVYFDLVGADD--------ALEVYTTRPDTLFGATYMVLAPEHELLdEITTDEHRED-------VDEYCRQAL 288
Cdd:TIGR00392 201 --KDPSIYVKFPVKKDKKtylkvklsSLLIWTTTPWTLPSNLAIAVHPDFEYA-LVQDNTKVEYfilakklVEKLYNKAG 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 289 RKSERKRQQQGDKtgvFTGGYAVNPVNGE-----EIPIWV--ADYVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVV 361
Cdd:TIGR00392 278 SDYEIIKTFKGSD---LEGLEYEHPLYDFvsqlkEGAPVVigGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPV 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 362 -EGGDIDEEAYTGDGPHVHSANEAV------SLNGLRN----------------------------------------EE 394
Cdd:TIGR00392 355 dEKGVYTEGVNDFQGRFVKDADKDIikankiIIEQLKDkglllkaekithsyphcwrtktpviyrateqwfiktkdikDQ 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 395 AKEAI--TEWLDEEEKGeRTVNY--QLQDWLFSRQRYWGEPFPIVFTEDGEDKPVPE--EEL--PVTLPDLDV-FEPSGT 465
Cdd:TIGR00392 435 MLEQIkkVNWVPEWGEG-RFGNWleNRPDWCISRQRYWGIPIPIWYCEDTGEPIVVGsiEELieLIELKGIDAwFEDLHR 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 466 PEGPLATIEDWRettdpetGEPAQRETNTMPQW--AGSCWYYLrFIDPDNDeqlvdpEKEEYWMPVDLYVGGSEHavlhl 543
Cdd:TIGR00392 514 DFLDKITLKSGD-------GGEYRRVPDVLDVWfdSGSMPYAS-IHYPFEN------EKFKEVFPADFILEGSDQ----- 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 544 lyARFWHKVLYDAGVVST-KEPFQTLVHQGMILgeteytayrddagefvsaeqvdddadltpvpvddgdvkkdgdvfvla 622
Cdd:TIGR00392 575 --TRGWFYSSLAIGTALFgQAPYKNVITHGFTL----------------------------------------------- 605
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 623 drpavrvDARSHKMSKSRGNVINPDDVVDEYGADTLRLYeMFMGPLEQDKPWSTDDMEGVHRFLNRIWRLVV-------- 694
Cdd:TIGR00392 606 -------DEKGRKMSKSLGNVVDPLKVINKYGADILRLY-VASSDPWEDLRFSDEILKQVVEKYRKIRWNTYrflltyan 677
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 695 ----DADSGGLAV-SDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEF-VNAANKW----------------DAL 752
Cdd:TIGR00392 678 ldkfDPLFNSVAVeKFPEEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFiVEELSNWyiriirdrlyceakdnDKR 757
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 753 PRQ-----VATPFVLLLSPFAPHLAEELWARL---GHDQSLAYADWPAYDDELI----------RREVVEMPVQVDGTVR 814
Cdd:TIGR00392 758 AAQttlyyALLTLVRLLAPFLPHTAEEIYQNLpggEEEESVHLNLWPEVDEEFIdealeanmaiVREIVEAFLALRDAAN 837
|
....
gi 123753431 815 ATIE 818
Cdd:TIGR00392 838 KKLR 841
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
2-840 |
3.84e-52 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 196.48 E-value: 3.84e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 2 AYPFHDIETKWQQYWEEHQTFrTPDevPDDQEEFYVldMFPYP--SGSgLHVGHpeGYTAT--DIVARYKRKQGFNVLhp 77
Cdd:PRK05729 8 TYDPKEVEAKWYQKWEEKGYF-KPD--DNSKKPFSI--VIPPPnvTGS-LHMGH--ALNNTlqDILIRYKRMQGYNTL-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 78 mgWdafgLPA------------EQYALKTNTHP----RET--------TEKNIAQFKRQLKRLGFSYDWQREINTTDPDY 133
Cdd:PRK05729 78 --W----LPGtdhagiatqmvvERQLAAEGKSRhdlgREKflekvwewKEESGGTITNQLRRLGASCDWSRERFTMDEGL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 134 YKWTQWIFLQLYEKGLAYQSEEPVWWCEELGTVLANEEVidgkserggypcervpmrqwvlkitEYADRllegledldwp 213
Cdd:PRK05729 152 SKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV-------------------------EYKEV----------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 214 estkemqrnwigrsEGANVYFD--LVGADDALEVYTTRPDTLFGATY-MVlapehelldeittdeHREDvdeycrqalrk 290
Cdd:PRK05729 196 --------------KGKLWHIRypLADGSDYLVVATTRPETMLGDTAvAV---------------NPED----------- 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 291 sERKRQqqgdktgvFTGGYAVNPVNGEEIPIwVAD-YVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVveggdIDEE 369
Cdd:PRK05729 236 -ERYKH--------LIGKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINI-----MDED 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 370 AytgdgphvHSANEAVSLNGLRNEEAKEAITEWLDEE---EK----------GERT-------------VNYQ------- 416
Cdd:PRK05729 301 G--------TINENPGEYQGLDRFEARKAIVADLEELgllVKiephthsvghSDRSgvviepylsdqwfVKMKplakpal 372
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 417 -------------------------LQDWLFSRQRYWGEPFPIVFTEDGEDKPVPEEELPVTLPDL----DVFE---PSG 464
Cdd:PRK05729 373 eavengeikfvperwektyfhwmenIQDWCISRQLWWGHRIPAWYDEDGEVYVGREEPEAREKALLtqdeDVLDtwfSSA 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 465 tpegpLatiedwrettdpetgepaqretntmpqWAGSC--WyylrfidPDNDEQLvdpekeEYWMPVDLYVGGsehavlh 542
Cdd:PRK05729 453 -----L---------------------------WPFSTlgW-------PEKTEDL------KRFYPTSVLVTG------- 480
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 543 llyarfwhkvlYD-----------AGVVSTKE-PFQT-LVHqGMIlgeteytayRDDAGEfvsaeqvdddadltpvpvdd 609
Cdd:PRK05729 481 -----------FDiiffwvarmimMGLHFTGQvPFKDvYIH-GLV---------RDEQGR-------------------- 519
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 610 gdvkkdgdvfvladrpavrvdarshKMSKSRGNVINPDDVVDEYGADTLRLYEMFMGPLEQDKPWSTDDMEGVHRFLNRI 689
Cdd:PRK05729 520 -------------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKL 574
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 690 W---RLV------VDADSGGLAVSDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVnaankWD---------- 750
Cdd:PRK05729 575 WnasRFVlmnlegADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFI-----WNefcdwylela 649
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 751 ----ALPRQVATPFVL---------LLSPFAPHLAEELWARLGHD---QSLAYADWPAYDDELIRREVVEMP-VQ--VDG 811
Cdd:PRK05729 650 kpvlQEAAKRATRATLayvleqilrLLHPFMPFITEELWQKLAPLgieESIMLAPWPEADEAIDEAAEAEFEwLKelITA 729
|
970 980 990
....*....|....*....|....*....|.
gi 123753431 812 --TVRATIEVAAdAEEADVLATAKEAENVAR 840
Cdd:PRK05729 730 irNIRAEMNIPP-SKKLPLLLKGADAEDRAR 759
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
1-834 |
2.60e-49 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 188.37 E-value: 2.60e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 1 MAYPFHDIETKWQQYWEEHQTFRTPDEVPDDQEEFYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGW 80
Cdd:COG0060 14 MRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGD-IHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 81 DAFGLPAEQYALKT----------------NTHPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYK--WtqWIFL 142
Cdd:COG0060 93 DCHGLPIELKVEKElgikkkdiekvgiaefREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEEsiW--WALK 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 143 QLYEKGLAYQSEEPVWWCEELGTVLANEEVidgkserggypcervpmrqwvlkitEYADRllegledldwpESTkemqrn 222
Cdd:COG0060 171 KLYEKGLLYKGLKPVPWCPRCGTALAEAEV-------------------------EYKDV-----------TSP------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 223 wigrsegaNVY--FDLVGADDALE-------VYTTRPDTLFGATYMVLAPEHE-LLDEITTDEH----REDVDEYCrqal 288
Cdd:COG0060 209 --------SIYvkFPVKDEKALLLledaylvIWTTTPWTLPANLAVAVHPDIDyVLVEVTGGERlilaEALVEAVL---- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 289 rksERKRQQQGDKTGVFTGG----------YAVNPVNGEEIPIWVADYVLVSYGTGAI-MAvPAHDERDHAFANKYDLPI 357
Cdd:COG0060 277 ---KELGIEDYEVLATFKGAeleglryehpFYYVVGYDRAHPVILGDYVTTEDGTGIVhTA-PGHGEDDFEVGKKYGLPV 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 358 REVVeggdiDEEA-YTGDGP-----HVHSANEAV----------------------------------------SLNGLR 391
Cdd:COG0060 353 LNPV-----DDDGrFTEEAPlfaglFVKDANPAIiedlkergallarekithsyphcwrcktpliyratpqwfiSMDKLR 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 392 nEEAKEAI--TEWLDEEEKG-------ERtvnyqlQDWLFSRQRYWGEPFPIVFTEDGeDKPVPEEELPVTLpdLDVFEP 462
Cdd:COG0060 428 -DRALEAIekVNWIPEWGEGrfgnmleNR------PDWCISRQRYWGVPIPIWVCEDC-GELHRTEEVIGSV--AELLEE 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 463 SGtpegplatIEDWRET-----------TDPETGEPAQRETNTMPQW--AGSCWYYlrfidpdndeQLVDpeKEEYWMPV 529
Cdd:COG0060 498 EG--------ADAWFELdlhrpfldetlKCPKCGGTMRRVPDVLDVWfdSGSMHFA----------VLEN--REELHFPA 557
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 530 DLYVGGS-EHavlhllyaRFWhkvlydagvvstkepFQTLvhqgMILGeteyTAYRDDA--------Gefvsaeqvddda 600
Cdd:COG0060 558 DFYLEGSdQT--------RGW---------------FYSS----LLTS----TALFGRApyknvlthG------------ 594
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 601 dltpvpvddgdvkkdgdvFVLadrpavrvDARSHKMSKSRGNVINPDDVVDEYGADTLRLYeMFMGPLEQDKPWSTDDME 680
Cdd:COG0060 595 ------------------FVL--------DEDGRKMSKSLGNVVDPQEVIDKYGADILRLW-VASSDYWGDLRFSDEILK 647
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 681 GVHRFLNRIW---RLVV------DADSGGLAVSD-EEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNA----- 745
Cdd:COG0060 648 EVRDVYRRLRntyRFLLanlddfDPAEDAVPYEDlPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEdlsnw 727
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 746 ----------ANKWDALPR--------QVATPFVLLLSPFAPHLAEELWARLGHD--QSLAYADWPAYDDELIR------ 799
Cdd:COG0060 728 yldiskdrlyTEAADSLDRraaqttlyEVLETLVRLLAPILPFTAEEIWQNLPGEaeESVHLADWPEVDEELIDeeleak 807
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*....
gi 123753431 800 ----REVVEM------PVQVDGTVR----ATIEVAADAEEADVLATAKE 834
Cdd:COG0060 808 wdlvREVRSAvlkaleAARKEKLIRqpleAAVVLYADEELAAALESLGD 856
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
674-779 |
5.04e-47 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 163.16 E-value: 5.04e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 674 WSTDDMEGVHRFLNRIWRLVVDADSGGLAVS----DEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANKW 749
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAaaaeLSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELVNALYKY 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 123753431 750 D-------ALPRQVATPFVLLLSPFAPHLAEELWARL 779
Cdd:cd07958 81 KkkdaqhaAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
2-804 |
5.03e-46 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 177.94 E-value: 5.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 2 AYPFHDIETKWQQYWEEHQTFRtPDevPDDQEEFYVLdMFPYP--SGSgLHVGHPEGYTATDIVARYKRKQGFNVLhpmg 79
Cdd:COG0525 6 TYDPKEVEAKWYQYWEENGYFK-AD--PDSDKEPFTI-VIPPPnvTGS-LHMGHALNNTLQDILIRYKRMQGYNTL---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 80 WdafgLP----A--------EQYALKTNTHPRETT-EKNIA---QFK--------RQLKRLGFSYDWQREINTTDPDYYK 135
Cdd:COG0525 77 W----QPgtdhAgiatqavvERQLAEEGKSRHDLGrEKFLErvwEWKeesggtitNQLRRLGASCDWSRERFTMDEGLSK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 136 WTQWIFLQLYEKGLAYQSEEPVWWCEELGTVLANEEVIdgkserggypcervpmrqwvlkiteyadrllegledldwpes 215
Cdd:COG0525 153 AVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVE------------------------------------------ 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 216 TKEMQrnwigrseGANVYF--DLVGADDALEVYTTRPDTLFGATY-MVlapehelldeittdeHREDvdeycrqalrksE 292
Cdd:COG0525 191 HEEVK--------GHLWHIryPLADGSGYIVVATTRPETMLGDTAvAV---------------HPED------------E 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 293 RKRQqqgdktgvFTGGYAVNPVNGEEIPIwVAD-YVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVveggdIDEEAy 371
Cdd:COG0525 236 RYKH--------LIGKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINI-----LDEDG- 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 372 tgdgphvHSANEAVSLNGLRNEEAKEAITEWLDEE---EK----------GERT-------------VNYQ--------- 416
Cdd:COG0525 301 -------TINENAGKYRGLDRFEARKAIVADLEELgllVKvephkhsvghSDRSgtviepylsdqwfVKMKplakpaiea 373
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 417 -----------------------LQDWLFSRQRYWGEPFPIVFTEDGEDKpVPEEElpvtlpdldvfepsgtPEG-PLAT 472
Cdd:COG0525 374 vedgeikfvperwektyfhwmenIRDWCISRQLWWGHRIPAWYCPDGEVY-VARTE----------------PEAcAKAG 436
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 473 IEDWRettdpetgepaqRETNTMPQWAGSC--------WyylrfidPDNDEQLvdpekeEYWMPVDLYVGGSEhavlhLL 544
Cdd:COG0525 437 SVNLT------------QDEDVLDTWFSSAlwpfstlgW-------PEKTEDL------KYFYPTSVLVTGFD-----II 486
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 545 YarFWhkvlydagvVS---------TKE-PFQT-LVHqGMIlgeteytayRDDAGEfvsaeqvdddadltpvpvddgdvk 613
Cdd:COG0525 487 F--FW---------VArmimmglhfTGEvPFKDvYIH-GLV---------RDEQGR------------------------ 521
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 614 kdgdvfvladrpavrvdarshKMSKSRGNVINPDDVVDEYGADTLRLYEMFMGPLEQDKPWSTDDMEGVHRFLNRIW--- 690
Cdd:COG0525 522 ---------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWnas 580
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 691 RLV------VDADSGGLAVSDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFV-------------------NA 745
Cdd:COG0525 581 RFVlmnlegFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwnefcdwylelakprlyggDE 660
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 123753431 746 ANKWDAlpRQVATpFVL-----LLSPFAPHLAEELWARLG---HDQSLAYADWPAYDDELIRREVVE 804
Cdd:COG0525 661 AAKRET--RATLV-YVLeqilrLLHPFMPFITEEIWQKLPprkEGESIMLAPWPEADEELIDEEAEA 724
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
36-671 |
2.35e-43 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 162.03 E-value: 2.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 36 YVLDMFP-YPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPA----EQYALKTNTHPR----------- 99
Cdd:cd00817 3 FVIDTPPpNVTGS-LHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATqvvvEKKLGIEGKTRHdlgreeflekc 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 100 -ETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWCEELGTVLANEEVidgkSE 178
Cdd:cd00817 82 wEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 179 RGGYPCERVPMRQWVLKITEYADRLLegledldwpESTKEMQRNWIgrseganvyfdlvgaddalevyttrpdtlfgaty 258
Cdd:cd00817 158 RSGDVIEPLLKPQWFVKVKDLAKKAL---------EAVKEGDIKFV---------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 259 mvlaPEHelldeittdehredvdeycrqalrkserkrqqqgdktgvftggyavnpvngeeipiWVADYVlvsygtgaima 338
Cdd:cd00817 195 ----PER--------------------------------------------------------MEKRYE----------- 203
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 339 vpahderdhafankydlpirevveggdideeaytgdgphvhsaneavslnglrneeakeaitEWLDEeekgertvnyqLQ 418
Cdd:cd00817 204 --------------------------------------------------------------NWLEN-----------IR 210
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 419 DWLFSRQRYWGEPFPIVFTEDGEDKPVPEEELPVTLPDLDVFEPSGTPegplatiEDWRettdpetgepaqRETNTMPQW 498
Cdd:cd00817 211 DWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAIDKAAPEACVPCGG-------EELK------------QDEDVLDTW 271
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 499 AGS-CWYYLRFIDPDNDEQLvdpeKEEYwmPVDLYVGGseHAVLhllyaRFWhkVLYD--AGVVSTKE-PFQTLVHQGMI 574
Cdd:cd00817 272 FSSsLWPFSTLGWPEETKDL----KKFY--PTSLLVTG--HDII-----FFW--VARMimRGLKLTGKlPFKEVYLHGLV 336
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 575 LgeteytayrddagefvsaeqvdddadltpvpvddgdvkkdgdvfvladrpavrvDARSHKMSKSRGNVINPDDVVDEYG 654
Cdd:cd00817 337 R------------------------------------------------------DEDGRKMSKSLGNVIDPLDVIDGYG 362
|
650
....*....|....*..
gi 123753431 655 ADTLRLYEMFMGPLEQD 671
Cdd:cd00817 363 ADALRFTLASAATQGRD 379
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
35-224 |
2.71e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 139.48 E-value: 2.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 35 FYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYA-------------LKTNTHPRET 101
Cdd:cd00668 2 FYVTTPPPYANGS-LHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 102 TEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVwwceelgtvlaneevidgksergg 181
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV------------------------ 136
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 123753431 182 ypcerVPMRQWVLKITEYADRLLEGLEDLDW-PESTKEMQRNWI 224
Cdd:cd00668 137 -----RITEQWFFDMPKFKEKLLKALRRGKIvPEHVKNRMEAWL 175
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
2-779 |
5.25e-36 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 147.45 E-value: 5.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 2 AYPFHDIETKWQQYWEEHQTFRTpDEVPDDQEEFYVLdmFPYPSGSG-LHVGHPEGYTATDIVARYKRKQGFNVLHPMGW 80
Cdd:PRK14900 18 GYEHREVEARWYPFWQERGYFHG-DEHDRTRPPFSIV--LPPPNVTGsLHLGHALTATLQDVLIRWKRMSGFNTLWLPGT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 81 DAFGLPA----EQYALKTNTHPR-------------ETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQ 143
Cdd:PRK14900 95 DHAGIATqmivEKELKKTEKKSRhdlgreaflervwAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 144 LYEKGLAYQSEEPVWWCEELGTVLANEEVIDGKSERGgypcervpmrqwvlkiteyadrllegledldwpestkemqrnw 223
Cdd:PRK14900 175 LHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQG------------------------------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 224 igrsEGANVYFDLVGADDALEVYTTRPDTLFGATYMVLAPEhelldeittdehredvdeycrqalrkSERKRQQQGDKTg 303
Cdd:PRK14900 212 ----ELWSFAYPLADGSGEIVVATTRPETMLGDTAVAVHPL--------------------------DPRYMALHGKKV- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 304 vftggyaVNPVNGEEIPIwVADYVLV--SYGTGAIMAVPAHDERDHAFANKYDLPIREVV-EGGDIDEEA---------- 370
Cdd:PRK14900 261 -------RHPITGRTFPI-VADAILVdpKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIgPDGRMTAEAgplagldrfe 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 371 --------------YTGDGPHVHS----ANEAVSLNGLRNEE--------AKEAI-------TEWLDEeekgERTVNY-- 415
Cdd:PRK14900 333 arkevkrllaeqglDRGAKPHVLPlgrcQRSATILEPLLSDQwyvrieplARPAIeaveqgrTRFIPE----QWTNTYma 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 416 ---QLQDWLFSRQRYWGEPFPIVFTEDGEdkPVPEEElpvtlpdldvfEPSGTPEGPLATIedwrettdpetgepaQRET 492
Cdd:PRK14900 409 wmrNIHDWCISRQLWWGHQIPAWYCPDGH--VTVARE-----------TPEACSTCGKAEL---------------RQDE 460
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 493 NTMPQWAGSC-WYYLRFIDPDNDEQLvdpekeEYWMPVDLYVGGseHAVLHLLYARFWHKVLYDAGVVstkePFQTLVHQ 571
Cdd:PRK14900 461 DVLDTWFSSGlWPFSTMGWPEQTDTL------RTFYPTSVMETG--HDIIFFWVARMMMMGLHFMGEV----PFRTVYLH 528
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 572 GMIlgeteytayRDDAGEfvsaeqvdddadltpvpvddgdvkkdgdvfvladrpavrvdarshKMSKSRGNVINPDDVVD 651
Cdd:PRK14900 529 PMV---------RDEKGQ---------------------------------------------KMSKTKGNVIDPLVITE 554
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 652 EYGADTLRLYEMFMGPLEQDKPWSTDDMEGVHRFLNRIWRLVVDA--DSGGLaVSDEEPDREQLRT------LHRTIKTV 723
Cdd:PRK14900 555 QYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNASRFAlmNLSGY-QERGEDPARLARTpadrwiLARLQRAV 633
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 724 TEDIEARD---FNTAIAAMMEFV-------------NAANKWDALPRQVATPFV--------LLLSPFAPHLAEELWARL 779
Cdd:PRK14900 634 NETVEALEafrFNDAANAVYAFVwhelcdwyielakEALASEDPEARRSVQAVLvhclqtsyRLLHPFMPFITEELWHVL 713
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
9-842 |
1.69e-31 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 132.59 E-value: 1.69e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 9 ETKWQQYWEEHQTFRTPDEvPDDQEEFYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAE 88
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSD-RNNGESFTLHDGPPYANGD-LHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 89 QYALKT--------------NTHPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSE 154
Cdd:PLN02843 87 LKVLQSldqearkeltpiklRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 155 EPVWWCEELGTVLANEEVidgksergGYPCERVPMRQWV-LKITEYADRLLEGLEDLdwpestkemqrnwigrseganvy 233
Cdd:PLN02843 167 KPVHWSPSSRTALAEAEL--------EYPEGHVSKSIYVaFPVVSPSETSPEELEEF----------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 234 fdLVGAddALEVYTTRPDTLFG---------ATYMVLAPEHELLDEITTDEHREDVDEYCRQALRKS------------E 292
Cdd:PLN02843 216 --LPGL--SLAIWTTTPWTMPAnaavavndkLQYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQQKLflivatdlvpalE 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 293 RKRQQQGDKTGVFTGGYAVN-----PVNGEEIPIWVA-DYVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVVE-GGD 365
Cdd:PLN02843 292 AKWGVKLVVLKTFPGSDLEGcryihPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDdAGK 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 366 IDEEAYTGDGPHVHSA-NEAV----------------------------------------SLNGLRnEEAKEAI--TEW 402
Cdd:PLN02843 372 FTEEAGQFSGLSVLGEgNAAVvealdeagsllmeeayghkypydwrtkkptifrateqwfaSVEGFR-QAALDAIdkVKW 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 403 LDEE-EKGERTVNYQLQDWLFSRQRYWGEPFPiVFTEDGEDKPVPEEElpvTLPDL-DVFEPSGTPEGPLATIEDWRETT 480
Cdd:PLN02843 451 IPAQgENRIRAMVSGRSDWCISRQRTWGVPIP-VFYHVETKEPLMNEE---TIAHVkSIVAQKGSDAWWYMDVEDLLPEK 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 481 DPETGEPAQRETNTMPQW--AGSCWyylrfidpdndeQLVDPEKEEYWMPVDLYVGGSEHavlHllyaRFWHKVLYDAGV 558
Cdd:PLN02843 527 YRDKASDYEKGTDTMDVWfdSGSSW------------AGVLGSREGLSYPADLYLEGSDQ---H----RGWFQSSLLTSV 587
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 559 VST-KEPFQTLVHQGmilgeteytayrddagefvsaeqvdddadltpvpvddgdvkkdgdvFVLadrpavrvDARSHKMS 637
Cdd:PLN02843 588 ATKgKAPYKSVLTHG----------------------------------------------FVL--------DEKGFKMS 613
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 638 KSRGNVINPDDVVD---------EYGADTLRLY--------EMFMGP--LEQdkpwsTDDM----EGVHRFLnriwrLVV 694
Cdd:PLN02843 614 KSLGNVVDPRLVIEggknqkqepAYGADVLRLWvasvdytgDVLIGPqiLKQ-----MSDIyrklRGTLRYL-----LGN 683
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 695 DAD-SGGLAVS-DEEP--DREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEF--VNAANKW-----DAL-------PRQV 756
Cdd:PLN02843 684 LHDwKPDNAVPyEDLPsiDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFtiVDLSNFYldvakDRLyvggttsFTRR 763
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 757 ATPFVL---------LLSPFAPHLAEELWARL--GHDQSLAY----ADWPAYDDELIRREVVEMP-----VQVDGTVRAT 816
Cdd:PLN02843 764 SCQTVLaahllsllrAIAPILPHLAEDAWQNLpfQEDGSAAEsvfeAGWPTPNEEWLSFPAEDVDfwsllLEVRDEVNKV 843
|
970 980 990 1000
....*....|....*....|....*....|....*....|....
gi 123753431 817 IEVA------------------ADAEEADVLATAKEAENVARHL 842
Cdd:PLN02843 844 LESArngkligasleakvylhaSDASLAARLAELCGASNGADEL 887
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
42-224 |
6.62e-31 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 123.80 E-value: 6.62e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 42 PYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSYD 121
Cdd:cd00814 9 PYVNGV-PHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFKWLNISFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 122 wqREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWCEELGTVLAneEVIDGKSerggypcervpmrqWVLKITEYAD 201
Cdd:cd00814 88 --YFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP--EWREEEH--------------YFFRLSKFQD 149
|
170 180
....*....|....*....|....*.
gi 123753431 202 RLLEGLE---DLDWPESTKEMQRNWI 224
Cdd:cd00814 150 RLLEWLEknpDFIWPENARNEVLSWL 175
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
16-791 |
4.87e-28 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 121.59 E-value: 4.87e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 16 WEEHQTFRTPDEvpDDQEEFYVLDMFPYPSGSGLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAE------- 88
Cdd:PLN02943 72 WWESQGYFKPNF--DRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQlvvekml 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 89 -QYALKTNTHPRETTEKNIAQFKR--------QLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWW 159
Cdd:PLN02943 150 aSEGIKRTDLGRDEFTKRVWEWKEkyggtitnQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNW 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 160 CEELGTVLANEEVidgkserggypcervpmrqwvlkitEYADrllegledldwpestkemqrnwigrsEGANVYFDLV-- 237
Cdd:PLN02943 230 SPNLQTAVSDLEV-------------------------EYSE--------------------------EPGTLYYIKYrv 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 238 --GADDALEVYTTRPDTLFGATYMVLAPEHelldeittdehredvDEYCRqalrkserkrqqqgdktgvFTGGYAVNPVN 315
Cdd:PLN02943 259 agGSEDFLTIATTRPETLFGDVAIAVNPED---------------DRYSK-------------------YIGKMAIVPMT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 316 -GEEIPIWVADYVLVSYGTGAIMAVPAHDERDHAFANKYDLPIREVV-EGGDIDE-------EAYTGDGPHVHSANEAV- 385
Cdd:PLN02943 305 yGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMnKDGTLNEvaglywfEAREKLWSDLEETGLAVk 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 386 ----SLNGLRNEEAKEAI-----TEW-----------LDEEEKGERTV---------NYQL---QDWLFSRQRYWGEPFP 433
Cdd:PLN02943 385 kephTLRVPRSQRGGEVIeplvsKQWfvtmeplaekaLKAVENGELTIiperfekiyNHWLsniKDWCISRQLWWGHRIP 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 434 IVFTEdGEDkpvPEEELPVTLPDLDVFEPSGTPEGplatiEDWRETTDPEtgepaqretnTMPQW-AGSCWYYLRFIDPD 512
Cdd:PLN02943 465 VWYIV-GKD---CEEDYIVARSAEEALEKAREKYG-----KDVEIYQDPD----------VLDTWfSSALWPFSTLGWPD 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 513 ndeqlVDPEKEEYWMPVDLYVGGseHAVLHllyarFWHKVLYDAGVVST-KEPFQTLVHQGMILgeteytayrddagefv 591
Cdd:PLN02943 526 -----VSAEDFKKFYPTTVLETG--HDILF-----FWVARMVMMGIEFTgTVPFSYVYLHGLIR---------------- 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 592 saeqvdddadltpvpvddgdvkkdgdvfvladrpavrvDARSHKMSKSRGNVINPDDVVDEYGADTLRlYEMFMGPLEQD 671
Cdd:PLN02943 578 --------------------------------------DSQGRKMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQD 618
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 672 KPWSTDDMEGVHRFLNRIWR---------------------LVVDADSGGLAVSDEEPDREQLRTLHRTIKTVTEDIEAR 730
Cdd:PLN02943 619 LNLSTERLTSNKAFTNKLWNagkfvlqnlpsqsdtsawehiLACKFDKEESLLSLPLPECWVVSKLHELIDSVTTSYDKY 698
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 731 DFNTAIAAMMEF----------------------VNAANKWDALPRQVATPFVLLLSPFAPHLAEELWARLGHD-QSLAY 787
Cdd:PLN02943 699 FFGDVGREIYDFfwsdfadwyieasktrlyhsgdNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYRkEALIV 778
|
....
gi 123753431 788 ADWP 791
Cdd:PLN02943 779 SPWP 782
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
42-224 |
1.20e-27 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 118.29 E-value: 1.20e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 42 PYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSYD 121
Cdd:COG0143 10 PYANGP-PHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELFEKLGISFD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 122 wqREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWW-----------------------------CEELGTVLANEEV 172
Cdd:COG0143 89 --NFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYcpecerflpdryvegtcpkcgaedaygdqCENCGATLEPTEL 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 123753431 173 IDGKSERGGYPCERVPMRQWVLKITEYADRLLEGLEDL-DW-PESTKEMQrNWI 224
Cdd:COG0143 167 INPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENpDIqPEVRNEVL-SWL 219
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
2-433 |
1.33e-26 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 117.03 E-value: 1.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 2 AYPFHDIETKWQQYWEEHQTFR-TPDEVPDDQEEFYVLdMFPYPSGSG-LHVGHPEGYTATDIVARYKRKQGFNVLHPMG 79
Cdd:PTZ00419 27 SYDPKEVESGWYEWWEKSGFFKpAEDAKSLNSGKKFVI-VLPPPNVTGyLHIGHALTGAIQDSLIRYHRMKGDETLWVPG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 80 WDAFGLpAEQYA-----LKTNTHPR-------------ETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIF 141
Cdd:PTZ00419 106 TDHAGI-ATQVVvekklMKEENKTRhdlgreeflkkvwEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 142 LQLYEKGLAYQSEEPVWWCEELGTVLANEEV--IDGKSerggypcervPMRqwvLKITEYadrllegledldwpESTKEM 219
Cdd:PTZ00419 185 VRLYEDGLIYRDTRLVNWCCYLKTAISDIEVefEEIEK----------PTK---ITIPGY--------------DKKVEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 220 QRNWigrsegaNVYFDLVGADDA-LEVYTTRPDTLFGATYMVLAPEhellDEITTDEHredvdeycrqalrkserkrqqq 298
Cdd:PTZ00419 238 GVLW-------HFAYPLEDSGQEeIVVATTRIETMLGDVAVAVHPK----DERYKKLH---------------------- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 299 gdktgvftGGYAVNP-VNGEEIPIwVADYVLV--SYGTGAIMAVPAHDERDHAFANKYDLPIREVV-EGGDIDEEAYTGD 374
Cdd:PTZ00419 285 --------GKELIHPfIPDRKIPI-IADDELVdmEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFtLDGKINENGGEFA 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 375 GPHVHSANEAV-----SLNGLRNEEAKEA----------ITE-------WLDEEEKGERTVN------------------ 414
Cdd:PTZ00419 356 GMHRFDCRRKIeeelkEMGLLRDKVPNPMrlprcsrsgdIVEpmlipqwYVNCKDMAKRAVEavrngelkiipsshenvw 435
|
490 500
....*....|....*....|...
gi 123753431 415 YQ----LQDWLFSRQRYWGEPFP 433
Cdd:PTZ00419 436 YHwlenIQDWCISRQLWWGHRIP 458
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
35-224 |
3.20e-26 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 111.61 E-value: 3.20e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 35 FYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLK 114
Cdd:pfam09334 1 ILVTTALPYANGP-PHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 115 RLGFSYDWQreINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWW-----------------------------CEELGT 165
Cdd:pfam09334 80 KFNISFDDY--GRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYcpsderflpdryvegtcphcgsedargdqCENCGR 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 123753431 166 VLANEEVIDGKSERGGYPCERVPMRQWVLKITEYADRLLEGLE--DLDWPESTKEMQRNWI 224
Cdd:pfam09334 158 HLEPTELINPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEenNPEWPENVKNMVLEWL 218
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
42-215 |
1.05e-25 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 112.28 E-value: 1.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 42 PYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSYD 121
Cdd:PRK11893 10 YYPNGK-PHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEALNISYD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 122 wqREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWCEELGTVLANEEVIDGK--SERGGYPCERVPMRQWVLKITEY 199
Cdd:PRK11893 89 --DFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDGyrCPPTGAPVEWVEEESYFFRLSKY 166
|
170
....*....|....*....
gi 123753431 200 ADRLLEGLEDLDW---PES 215
Cdd:PRK11893 167 QDKLLELYEANPDfiqPAS 185
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
33-224 |
1.16e-22 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 100.00 E-value: 1.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 33 EEFYVLDMFPYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKT-----------------N 95
Cdd:cd00818 1 PEFVFHDGPPYANGL-PHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKElgisgkkdiekmgiaefN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 96 THPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWceelgtvlaneevidg 175
Cdd:cd00818 80 AKCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW---------------- 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 123753431 176 kserggyPCERVPMRQWVLKITEYADRLLEGLEDLDW-PESTKEMQRNWI 224
Cdd:cd00818 144 -------PLIYRATPQWFIRVTKIKDRLLEANDKVNWiPEWVKNRFGNWL 186
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
3-810 |
1.44e-22 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 104.42 E-value: 1.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 3 YPFHDIETKWQQYWEEHQTFRTPDEVPDDQEEFYVLDMFPYpsGSGL-HVGHPEGYTATDIVARYKRKQGFNVLHPMGWD 81
Cdd:PLN02882 8 FSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPF--ATGLpHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 82 AFGLPAEqYAL------------------KTNTHPRETTEKNIAQFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQ 143
Cdd:PLN02882 86 CHGLPVE-YEIdkklgikrrddvlkmgidKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 144 LYEKGLAYQSEEPVWWCEELGTVLANEEVidGKSERggypcervpmrqwvlkiteyadrllegleDLDWPEstkemqrnw 223
Cdd:PLN02882 165 LFEKGLVYKGFKVMPYSTACKTPLSNFEA--GLNYK-----------------------------DVSDPA--------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 224 igrsegANVYFDLVGADD--ALEVYTTRPDTLFGATYMVLAPEHELLDEITTDEHREDVDEYCRQALRKSERKRQQQGDK 301
Cdd:PLN02882 205 ------VMVSFPIVGDPDnaSFVAWTTTPWTLPSNLALCVNPNFTYVKVRNKYTGKVYIVAESRLSALPTAKPKSKKGSK 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 302 TGVFTGGYAV-NPVNGEEI------PIW-------------VAD-YVLVSYGTGAIMAVPAHDERDH--AFANKY----- 353
Cdd:PLN02882 279 PENAAEGYEVlAKVPGSSLvgkkyePLFdyfsefsdtafrvVADdYVTDDSGTGVVHCAPAFGEDDYrvCLANGIiekgg 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 354 DLPIrEVVEGGDIDEEAYTGDGPHVHSAN----EAVSLNG-------------------------------LRNEEAKEA 398
Cdd:PLN02882 359 NLPV-PVDDDGCFTEKVTDFSGRYVKDADkdiiAAIKAKGrlvksgsithsypfcwrsdtpliyravpswfVKVEEIKDR 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 399 I------TEWLDEEEKGERTVNY--QLQDWLFSRQRYWGEPFPIVFTEDGEDKPVPE-----EELP-VTLPDL------D 458
Cdd:PLN02882 438 LlennkqTYWVPDYVKEKRFHNWleNARDWAVSRSRFWGTPLPIWISDDGEEVVVIGsiaelEKLSgVKVTDLhrhfidH 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 459 VFEPSG-TPE-GPLATIED----WrettdpetgepaqRETNTMPqwagscWYYLRFidpdndeqlvdP-EKEEYW---MP 528
Cdd:PLN02882 518 ITIPSSrGPEfGVLRRVDDvfdcW-------------FESGSMP------YAYIHY-----------PfENKELFeknFP 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 529 VDLYVGGsehavlhLLYARFWhkvLYDAGVVST----KEPFQTLVHQGMILGEteytayrddagefvsaeqvdddadltp 604
Cdd:PLN02882 568 ADFVAEG-------LDQTRGW---FYTLMVLSTalfdKPAFKNLICNGLVLAE--------------------------- 610
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 605 vpvddgdvkkdgdvfvladrpavrvDARshKMSKSRGNVINPDDVVDEYGADTLRLYeMFMGPLEQDKPWSTDDmEGVH- 683
Cdd:PLN02882 611 -------------------------DGK--KMSKSLKNYPDPNEVIDKYGADALRLY-LINSPVVRAEPLRFKE-EGVFg 661
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 684 -------------RFL-NRIWRLVVDA-------DSGGLAVSDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEF 742
Cdd:PLN02882 662 vvkdvflpwynayRFLvQNAKRLEVEGgapfvplDLAKLQNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKF 741
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 743 V-NAANKWDALPRQ--------------VATPF-VLL-----LSPFAPHLAEELWARL-----GHDQSLAYADWPAYD-- 794
Cdd:PLN02882 742 IdNLTNIYVRFNRKrlkgrtgeedcrtaLSTLYnVLLtsckvMAPFTPFFTEVLYQNLrkvlpGSEESIHYCSFPQVDeg 821
|
970
....*....|....*...
gi 123753431 795 --DELIRREVVEMPVQVD 810
Cdd:PLN02882 822 elDERIEQSVSRMQTVIE 839
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
635-791 |
8.79e-22 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 100.19 E-value: 8.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 635 KMSKSRGNVINPDDVVDEYGADTLRLYEMFMGPLEQDKPWSTDDMegVHR-----------FLNRIWRLVVDADSGGL-- 701
Cdd:COG0143 327 KMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEDF--VARvnsdlandlgnLASRTLSMIHKYFDGKVpe 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 702 AVSDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANK-------W----DALPRQVATpfVL-------- 762
Cdd:COG0143 405 PGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALARAANKyidetapWklakDEDPERLAT--VLytllealr 482
|
170 180 190
....*....|....*....|....*....|....*.
gi 123753431 763 ----LLSPFAPHLAEELWARLG---HDQSLAYADWP 791
Cdd:COG0143 483 ilaiLLKPFLPETAEKILEQLGlegDELTWEDAGWP 518
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
635-785 |
6.07e-19 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 91.10 E-value: 6.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 635 KMSKSRGNVINPDDVVDEYGADTLRLY---EMfmgPLEQDKPWSTDDMegVHRF-----------LNRIWRLVVDaDSGG 700
Cdd:PRK11893 299 KMSKSLGNVIDPFDLVDEYGVDAVRYFllrEI---PFGQDGDFSREAF--INRInadlandlgnlAQRTLSMIAK-NFDG 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 701 L---AVSDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANKW----------DALPRQVATP-------- 759
Cdd:PRK11893 373 KvpePGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVRAANKYideqapwslaKTDPERLATVlytllevl 452
|
170 180
....*....|....*....|....*...
gi 123753431 760 --FVLLLSPFAPHLAEELWARLGHDQSL 785
Cdd:PRK11893 453 rgIAVLLQPVMPELAAKILDQLGVEEDE 480
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
709-825 |
2.04e-18 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 82.45 E-value: 2.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 709 DREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFV-NAANKW------------DALPRQVAT------PFVLLLSPFAP 769
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWylelikdrlygeEPDSRAQTTlyevleTLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 123753431 770 HLAEELWarlgHDQSLAYADWP----AYDDELIRR-EVVEMPVQVDGTVRATIEVAADAEE 825
Cdd:pfam08264 81 FITEELW----QKESIHLAPWPedaeLEEAELEEAfELRQEIVQAIRKLRSELKIKKSLPL 137
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
8-406 |
7.48e-18 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 88.80 E-value: 7.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 8 IETKWQQYWEEHQTFRTpdEVPDDQEEFYVLdmFPYPSGSG-LHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLP 86
Cdd:PLN02381 105 VEKSWYAWWEKSGYFGA--DAKSSKPPFVIV--LPPPNVTGaLHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIA 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 87 AEQYALKTNTHPRETTEKNIAQFK-----------------RQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGL 149
Cdd:PLN02381 181 TQVVVEKKLMRERHLTRHDIGREEfvsevwkwkdeyggtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 150 AYQSEEPVWWCEELGTVLANEEV--IDGKSERggypcervpmrqwVLKITEYADRLLEG-LEDLDWPestkemqrnwigr 226
Cdd:PLN02381 261 IYRDIRLVNWDCTLRTAISDVEVdyIDIKERT-------------LLKVPGYDKPVEFGvLTSFAYP------------- 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 227 seganvyfdLVGADDALEVYTTRPDTLFGATYMVLAPEhellDEITTDEHredvdeycrqalrkserkrqqqgdktgvft 306
Cdd:PLN02381 315 ---------LEGGLGEIVVATTRIETMLGDTAIAIHPD----DERYKHLH------------------------------ 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 307 GGYAVNPVNGEEIPIwVADYVLV--SYGTGAIMAVPAHDERDHAFANKYDLPIREVveggdideeaYTGDGPhvHSANEA 384
Cdd:PLN02381 352 GKFAVHPFNGRKLPI-ICDAILVdpNFGTGAVKITPAHDPNDFEVGKRHNLEFINI----------FTDDGK--INSNGG 418
|
410 420
....*....|....*....|..
gi 123753431 385 VSLNGLRNEEAKEAITEWLDEE 406
Cdd:PLN02381 419 SEFAGMPRFAAREAVIEALQKK 440
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
43-224 |
8.04e-18 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 88.32 E-value: 8.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 43 YPSGSgLHVGHpeGYT--ATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSY 120
Cdd:PRK12267 14 YPNGK-PHIGH--AYTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKELWKKLDISY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 121 DwqREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWC---EELGTVlaNEEVIDGKSERGGYPCERVPMRQWVLKIT 197
Cdd:PRK12267 91 D--KFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCvscETFFTE--SQLVDGGKCPDCGREVELVKEESYFFRMS 166
|
170 180 190
....*....|....*....|....*....|.
gi 123753431 198 EYADRLLEGLE---DLDWPESTK-EMQRNWI 224
Cdd:PRK12267 167 KYQDRLLEYYEenpDFIQPESRKnEMINNFI 197
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
635-786 |
2.12e-17 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 86.78 E-value: 2.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 635 KMSKSRGNVINPDDVVDEYGADTLRLY---EMfmgPLEQDKPWSTDDMegVHRF-----------LNRI-------WRLV 693
Cdd:PRK12267 299 KMSKSKGNVVDPEELVDRYGLDALRYYllrEV---PFGSDGDFSPEAL--VERInsdlandlgnlLNRTvaminkyFDGE 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 694 VDADSGGlavsdEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANK-------W----------------- 749
Cdd:PRK12267 374 IPAPGNV-----TEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLISRANKyidetapWvlakdegkkerlatvmy 448
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 123753431 750 ---DALpRQVAtpfvLLLSPFAPHLAEELWARLGHDQSLA 786
Cdd:PRK12267 449 hlaESL-RKVA----VLLSPFMPETSKKIFEQLGLEEELT 483
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-224 |
3.75e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 73.26 E-value: 3.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 42 PYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSYD 121
Cdd:PRK00133 11 PYANGP-IHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPEELIARYHAEHKRDFAGFGISFD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 122 -WQReinTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWW-----------------------------CEELGTVLANEE 171
Cdd:PRK00133 90 nYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYdpekgmflpdrfvkgtcpkcgaedqygdnCEVCGATYSPTE 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 123753431 172 VIDGKSERGGYPCERVPMRQWVLKITEYADRLLEGLE-DLDWPESTKEMQRNWI 224
Cdd:PRK00133 167 LINPKSAISGATPVLKESEHFFFKLPRFEEFLKEWITrSGELQPNVANKMKEWL 220
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
9-153 |
4.67e-11 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 66.91 E-value: 4.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 9 ETKWQQYWEEHQTFRTPDEVPDDQEEFYVLDMFPYPSGSGlHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAE 88
Cdd:PTZ00427 78 EEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLP-HYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIE 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 89 -QYALKTNTHPRET---------TEK--NIA-----QFKRQLKRLGFSYDWQREINTTDPDYYKWTQWIFLQLYEKGLAY 151
Cdd:PTZ00427 157 yEIEKENNINKKEDilkmgidvyNEKcrGIVlkysnEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVY 236
|
..
gi 123753431 152 QS 153
Cdd:PTZ00427 237 KS 238
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
635-859 |
5.48e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 66.33 E-value: 5.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 635 KMSKSRGNVINPDDVVDEYGADTLRLYEMFMGPLE-QDKPWSTDDmegvhrFLNRiwrlvVDAD-----------SGGLA 702
Cdd:PRK00133 329 KMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPETiDDLDFNWED------FQQR-----VNSElvgkvvnfasrTAGFI 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 703 -------VSDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANK-------W---------------DALp 753
Cdd:PRK00133 398 nkrfdgkLPDALADPELLEEFEAAAEKIAEAYEAREFRKALREIMALADFANKyvddnepWklakqdgerlqavcsVGL- 476
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 754 rQVATPFVLLLSPFAPHLAEELWARLGHDqSLAYADW---------PAYdDELIRRevVEmPVQVDGTVRATIEVAADAE 824
Cdd:PRK00133 477 -NLFRALAIYLKPVLPELAERAEAFLNLE-ELTWDDAqqplaghpiNKF-KILFTR--IE-DKQIEALIEASKEAAAAKA 550
|
250 260 270
....*....|....*....|....*....|....*.
gi 123753431 825 EADVLATAKEAENVARHLDDEDLQR-EIYVpGQIVN 859
Cdd:PRK00133 551 AAAAAAAPLAEEPIAETISFDDFAKvDLRV-AKIVE 585
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
674-779 |
5.89e-11 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 61.03 E-value: 5.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 674 WSTDDMEGVHRFLNRIW---RLVV-----DADSGGLAVSDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVna 745
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWnaaRFVLmnledDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFF-- 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 746 ankWDAL-----------------PRQVATPFVL---------LLSPFAPHLAEELWARL 779
Cdd:cd07962 79 ---WNDFcdwylelvkprlygedeEEKKAARATLyyvletilrLLHPFMPFITEELWQRL 135
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
635-749 |
1.58e-10 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 64.35 E-value: 1.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 635 KMSKSRGNVINPDDVVDEYGADTLRLYeMFMG----PLEqdkpWSTDDMEGVHRFLNRIWRLVVDADSGGLAVSDEEPDR 710
Cdd:COG0215 265 KMSKSLGNFFTVRDLLKKYDPEVLRFF-LLSAhyrsPLD----FSEEALEEAEKALERLYNALRRLEEALGAADSSAEEI 339
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 123753431 711 EQLRtlhrtiktvtEDIEAR---DFNT--AIAAMMEFVNAANKW 749
Cdd:COG0215 340 EELR----------EEFIAAmddDFNTpeALAVLFELVREINKA 373
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
716-821 |
1.36e-09 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 58.33 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 716 LHRTIKTVTEDIEARDFNTAIAAMMEFVNAANKW-------------------DALprqvATPF-VL-----LLSPFAPH 770
Cdd:cd07961 56 LNSLIKEVTEEMEAYDLYTAVRALLEFIDELTNWyirrnrkrfwgeegdddklAAY----ATLYeVLltlsrLMAPFTPF 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 123753431 771 LAEELWARLGHDQSLA-----YADWPAYDDELIRREVVEmpvQVDgTVRATIEVAA 821
Cdd:cd07961 132 ITEEIYQNLRRELGDApesvhLLDWPEVDESLIDEELEE---AME-LVREIVELGR 183
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
7-148 |
1.85e-09 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 61.62 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 7 DIETKWQQYWEEHQTFRT--PDEVPDDQEEFYVldMFPYPSGSG-LHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAF 83
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAeaGDEPPKPGEKFFG--NFPYPYMNGlLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 84 GLP-----------AEQY---------------ALKTNTHPRET----------------------------------TE 103
Cdd:PLN02959 95 GMPikasadklareIQQYgnppvfpeededeaaAVAAAKAEAEAaaappdkfkgkkskavaksgtqkyqweimrsfglPD 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 123753431 104 KNIAQF--------------KRQLKRLGFSYDWQREINTTD--PDYYKWTQWIFLQLYEKG 148
Cdd:PLN02959 175 SEIAKFqdpyhwlsyfpplaKEDLKAFGLGCDWRRSFITTDvnPYYDAFVRWQFRKLKKKG 235
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
682-779 |
5.24e-09 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 55.19 E-value: 5.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 682 VHRFLNRIWR---LVVDADSGglavsDEEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANK-------W-- 749
Cdd:cd07957 13 VNRTLNMASKyfgGVVPEFGG-----LTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELARAANKyidetapWkl 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 123753431 750 --DALPRQVATpfVL------------LLSPFAPHLAEELWARL 779
Cdd:cd07957 88 akEEDPERLAT--VLyvllellrilaiLLSPFMPETAEKILDQL 129
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
635-671 |
1.90e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 56.77 E-value: 1.90e-08
10 20 30
....*....|....*....|....*....|....*..
gi 123753431 635 KMSKSRGNVINPDDVVDEYGADTLRLYEMFMGPLEQD 671
Cdd:cd00814 280 KMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKD 316
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
674-779 |
6.05e-08 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 51.82 E-value: 6.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 674 WSTDDMEGVHRFLNRIWRLVVDADSGGLAVSDEE-PDREQLRTLHRTIKTVTEDIEARDFNTAI-AAMMEFVNA------ 745
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEGELEELTfIDRWLLSRLNRLIKETTEAYENMQFREALkEGLYELQNDldwyre 80
|
90 100 110
....*....|....*....|....*....|....*....
gi 123753431 746 -----ANKWdaLPRQVATPFVLLLSPFAPHLAEELWARL 779
Cdd:cd07959 81 rggagMNKD--LLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
679-749 |
6.84e-08 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 51.74 E-value: 6.84e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 123753431 679 MEGVHRFLNRIWRLV-VDADSGGLAVSD------EEPDREQLRTLHRTIKTVTEDIEARDFNTAIAAMMEFVNAANKW 749
Cdd:cd07375 4 LKQARAFLNRLYRLLsFFRKALGGTQPKwdnellEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNELNWY 81
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
61-173 |
3.78e-06 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 50.55 E-value: 3.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 61 DIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQLKRLGFSYDwqREINTTDPDYYKWTQWI 140
Cdd:PLN02610 45 DVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEICDKYHAIHKEVYDWFDISFD--KFGRTSTPQQTEICQAI 122
|
90 100 110
....*....|....*....|....*....|...
gi 123753431 141 FLQLYEKGLAYQSEEPVWWCEELGTVLANEEVI 173
Cdd:PLN02610 123 FKKLMENNWLSENTMQQLYCDTCQKFLADRLVE 155
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
31-160 |
1.61e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 42.01 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123753431 31 DQEEFYVLDMFPYPSGSGLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFK 110
Cdd:PLN02224 66 DEADTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEHCDIISQSYR 145
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 123753431 111 RQLKRLGFSYDwqREINTTDPDYYKWTQWIFLQLYEKGLAYQSEEPVWWC 160
Cdd:PLN02224 146 TLWKDLDIAYD--KFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYC 193
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
42-113 |
2.82e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 39.00 E-value: 2.82e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 123753431 42 PYPSGSgLHVGHPEGYTATDIVARYKRKQGFNVLHPMGWDAFGLPAEQYALKTNTHPRETTEKNIAQFKRQL 113
Cdd:cd00802 6 ITPNGY-LHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKEDV 76
|
|
| |
