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Conserved domains on  [gi|119361608|sp|Q32GZ6|]
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RecName: Full=Peptide chain release factor 1; Short=RF-1

Protein Classification

peptide chain release factor 1( domain architecture ID 11415460)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-357 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 683.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   4 SIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMML---DDPEMREMAQD 80
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLeeeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  81 ELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYK 160
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 161 EIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELpDINPADLRIDTFRSSGAGGQHVNTT 240
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDV-EINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 241 DSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDH 320
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 119361608 321 RINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALS 357
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-357 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 683.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   4 SIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMML---DDPEMREMAQD 80
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLeeeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  81 ELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYK 160
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 161 EIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELpDINPADLRIDTFRSSGAGGQHVNTT 240
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDV-EINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 241 DSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDH 320
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 119361608 321 RINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALS 357
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 2-358 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 680.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   2 KPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMML---DDPEMREMA 78
Cdd:PRK00591   1 KPSMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLeeeSDPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  79 QDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGG 158
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 159 YKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAElPDINPADLRIDTFRSSGAGGQHVN 238
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVE-VEINPKDLRIDTFRSSGAGGQHVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 239 TTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVT 318
Cdd:PRK00591 240 TTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 119361608 319 DHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSE 358
Cdd:PRK00591 320 DHRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-359 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 609.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608    1 MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLD--DPEMREMA 78
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEesDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   79 QDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGG 158
Cdd:TIGR00019  81 KEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  159 YKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAElPDINPADLRIDTFRSSGAGGQHVN 238
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVE-VDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  239 TTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVT 318
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 119361608  319 DHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQ 359
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSEE 360
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-203 4.14e-107

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 311.62  E-value: 4.14e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   12 LHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQ 91
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDPELAELAEEELEELEKRLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   92 LEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGV 171
Cdd:pfam03462  81 LEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGA 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 119361608  172 YGRLKFESGGHRVQRVPATESQGRIHTSACTV 203
Cdd:pfam03462 161 YGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
68-178 5.21e-54

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 173.42  E-value: 5.21e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608    68 MLDDPEMREMAQDELREAKEKSEQLEQQLQVLL-LPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRV 146
Cdd:smart00937   5 EEEDDEMRELAEEELEELEAELEEELEELLKLLlLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKGWKV 84

                           90       100       110
                   ....*....|....*....|....*....|..
gi 119361608   147 EIMSASEGEHGGYKEIIAKISGDGVYGRLKFE 178
Cdd:smart00937  85 EVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-357 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 683.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   4 SIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMML---DDPEMREMAQD 80
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLeeeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  81 ELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYK 160
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 161 EIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELpDINPADLRIDTFRSSGAGGQHVNTT 240
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDV-EINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 241 DSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDH 320
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 119361608 321 RINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALS 357
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 2-358 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 680.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   2 KPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMML---DDPEMREMA 78
Cdd:PRK00591   1 KPSMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLeeeSDPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  79 QDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGG 158
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 159 YKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAElPDINPADLRIDTFRSSGAGGQHVN 238
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVE-VEINPKDLRIDTFRSSGAGGQHVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 239 TTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVT 318
Cdd:PRK00591 240 TTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 119361608 319 DHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSE 358
Cdd:PRK00591 320 DHRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-359 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 609.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608    1 MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLD--DPEMREMA 78
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEesDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   79 QDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGG 158
Cdd:TIGR00019  81 KEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  159 YKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAElPDINPADLRIDTFRSSGAGGQHVN 238
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVE-VDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  239 TTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVT 318
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 119361608  319 DHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQ 359
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSEE 360
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-203 4.14e-107

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 311.62  E-value: 4.14e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   12 LHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQ 91
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDPELAELAEEELEELEKRLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   92 LEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGV 171
Cdd:pfam03462  81 LEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGA 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 119361608  172 YGRLKFESGGHRVQRVPATESQGRIHTSACTV 203
Cdd:pfam03462 161 YGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 8-342 4.74e-83

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 256.63  E-value: 4.74e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608    8 KLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRcftDWQQVQEDIETAQMML------DDPEMREMAQDE 81
Cdd:TIGR00020  24 DPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLD---TLEELKNSLEDLSELLelaveeDDEETFNELDAE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608   82 LREAKEKSEQLEQQLQVlllpKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKE 161
Cdd:TIGR00020 101 LKALEKKLAELELRTML----SGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  162 IIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTD 241
Cdd:TIGR00020 177 VTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASGAGGQHVNKTD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  242 SAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKrQQAEASTRRnllgsGDRSD-----RNRTYNF-PQG 315
Cdd:TIGR00020 257 SAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEK-EQAEKDAKE-----GEKSEigwgsQIRSYVLhPYS 330

                         330       340
                  ....*....|....*....|....*..
gi 119361608  316 RVTDHRINLTLYRLDEVMEGKLDMLIE 342
Cdd:TIGR00020 331 MVKDLRTGYETGNVQAVLDGDIDQFIE 357
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 45-342 5.95e-67

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 213.75  E-value: 5.95e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  45 LSDVSRcFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLeqqlqvlllpkdpdDERNAFLEVRAGTGGDEA 124
Cdd:PRK08787  16 LADAGE-LLDLAESEQDEDTALAVIADLDKYQAHVEKLEFQRMFSGQM--------------DGANAFVDIQAGAGGTEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 125 ALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVA 204
Cdd:PRK08787  81 QDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 205 VMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMA 284
Cdd:PRK08787 161 VSPEVDDNIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQ 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119361608 285 KR---QQAEASTRRNlLGSGDRSdrnRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIE 342
Cdd:PRK08787 241 KRnaeKDALEATKSD-IGWGSQI---RNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVE 297
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 25-342 1.91e-66

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 213.20  E-value: 1.91e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  25 DAQTIADQERFRALSREYAQLSDV---SRCFTdwQQVQEDIETAQM--MLDDPEMREMAQDELREAKEKSEQLEQQLQVL 99
Cdd:PRK07342   5 DPSLWNDAQEAQKLMRERQQLDDSingINHLE--QTLNDNIELIAMgeEEGDKSIVEDAEKTIRDLKDEIDRRQIDALLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 100 LLPkdpdDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFES 179
Cdd:PRK07342  83 GEA----DANDTYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTES 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 180 GGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQD 259
Cdd:PRK07342 159 GVHRLVRISPYDSNARRHTSFASIWVYPVIDDNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 260 ERSQHKNKAKALSVLGARIHAAEMAKRQQ---AEASTRRNlLGSGDRSdrnRTYNF-PQGRVTDHRINLTLYRLDEVMEG 335
Cdd:PRK07342 239 ERSQHKNRAKAWSMLRARLYEEELKKREEatnAAAASKTD-IGWGHQI---RSYVLqPYQLVKDLRTGVESTNPQDVLDG 314


                 ....*..
gi 119361608 336 KLDMLIE 342
Cdd:PRK07342 315 DLNEFME 321
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 60-341 1.52e-63

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 205.42  E-value: 1.52e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  60 EDIETAQMMLDDPEmREMAQDELREAKEKSEQLEQQLQVLLLPKDPDdERNAFLEVRAGTGGDEAALFAGDLFRMYSRYA 139
Cdd:PRK05589  38 EDIEVLCEMMSEED-DEMKKEIISEVKNIKEEIDRFKIETLLSGEYD-RNNAILTLHSGVGGTDAQDWTEMLLRMYTRWA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 140 EARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINP 219
Cdd:PRK05589 116 EKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANGKRQTSFASVEVLPELTDDQDIEIRS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 220 ADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGAR-IHAAEMAKRQQAEASTrrnll 298
Cdd:PRK05589 196 EDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKlVELKERAHKEKIEDLT----- 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 119361608 299 gsGDRSDRN-----RTYNF-PQGRVTDHRINLTLYRLDEVMEGKLDMLI 341
Cdd:PRK05589 271 --GELKDMGwgsqiRSYVFhPYNLVKDHRTGVETSNVDSVMDGDIDNFI 317
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 216-321 6.79e-59

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 185.70  E-value: 6.79e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  216 DINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRR 295
Cdd:pfam00472   6 EIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKRRIKS 85

                          90       100
                  ....*....|....*....|....*..
gi 119361608  296 nLLGSGDRSDRNRTYNF-PQGRVTDHR 321
Cdd:pfam00472  86 -QVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 31-346 2.85e-56

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 186.48  E-value: 2.85e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  31 DQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDpEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERN 110
Cdd:PRK06746   9 DQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKE-EYDEDLHEELESEVKGLIQEMNEYELQLLLSDPYDKNN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 111 AFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPAT 190
Cdd:PRK06746  88 AILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 191 ESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKA 270
Cdd:PRK06746 168 DSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHA 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119361608 271 LSVLGARIHAAEMaKRQQAEASTRRNLLGSGDRSDRNRTYNF-PQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQ 346
Cdd:PRK06746 248 MKMLKAKLYQKKL-EEQQAELDEIRGEQKEIGWGSQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYLR 323
PCRF smart00937
This domain is found in peptide chain release factors;
68-178 5.21e-54

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 173.42  E-value: 5.21e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608    68 MLDDPEMREMAQDELREAKEKSEQLEQQLQVLL-LPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRV 146
Cdd:smart00937   5 EEEDDEMRELAEEELEELEAELEEELEELLKLLlLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKGWKV 84

                           90       100       110
                   ....*....|....*....|....*....|..
gi 119361608   147 EIMSASEGEHGGYKEIIAKISGDGVYGRLKFE 178
Cdd:smart00937  85 EVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 216-305 1.73e-34

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 123.70  E-value: 1.73e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 216 DINPADLRIDTFRSSGAGGQHVNTTDSAIRITH------------LPTGIVVECQDERSQHKNKAKALSVLGARIHAAEM 283
Cdd:COG1186   22 EIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEAEL 101

                         90       100
                 ....*....|....*....|....*..
gi 119361608 284 AKRQQA-----EASTRRNLLGSGDRSD 305
Cdd:COG1186  102 EPKERRatkptRGSKKRRLWGKQIRSM 128
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 112-310 9.96e-27

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 105.24  E-value: 9.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  112 FLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEH-GGYKEIIAKISGDGVYGRLKFESGGHRVqrvpAT 190
Cdd:TIGR03072   2 LLQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVpGTLRSALVSLDGEAAAALADRWEGTLLW----IC 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608  191 ESQGRIHTSACT--VAVMPElpdAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKA 268
Cdd:TIGR03072  78 PSPYRPHHRRKNwfIGVQRF---SASEEATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKR 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 119361608  269 KALSVLGARIHAAEMAKRqQAEASTRRNLLGSGDRSDRNRTY 310
Cdd:TIGR03072 155 LATLLLAVRLADLQQEQA-AALRAERRTAHHQIERGNPVRVF 195
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
217-308 6.78e-09

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 53.62  E-value: 6.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361608 217 INPADLRIDTFRSSGAGGQHVNTTDSA------IRITHLP---------------TG---IVVECQDERSQHKNKAKALS 272
Cdd:PRK09256  10 IPENELEWRFIRASGPGGQNVNKVSTAvelrfdIAASSLPefykerllalaghriTKdgvIVIKAQEFRSQERNREDALE 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 119361608 273 VLGARI-HAAEMAKRQQA----EASTRRNLLGSGDRSD--RNR 308
Cdd:PRK09256  90 RLVALIrEALKPPKKRRAtkptRGSKERRLESKKQRGEvkALR 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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